Meclizine (BioDeep_00000002451)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine

化学式: C25H27ClN2 (390.18626520000004)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl
InChI: InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3

描述信息

Meclizine is only found in individuals that have used or taken this drug. It is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. [PubChem]Along with its actions as an antagonist at H₁-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AE - Piperazine derivatives
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3084
D002491 - Central Nervous System Agents
D018926 - Anti-Allergic Agents

同义名列表

29 个代谢物同义名

1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine; Pfizer consumer healthcare brand OF meclizine dihydrochloride; Pfizer brand 1 OF meclizine dihydrochloride; Pfizer brand 2 OF meclizine dihydrochloride; Roberts brand OF meclizine dihydrochloride; Torrens brand OF meclizine dihydrochloride; Vedim brand OF meclizine dihydrochloride; Monohydrochloride, meclizine; Meclizine monohydrochloride; Dihydrochloride, meclizine; Meclizine dihydrochloride; Hydrochloride, meclizine; Meclizine hydrochloride; Parachloramine; Histametizyn; Nevidoxine; meclizine; Ru-vert-m; Meclozine; Ru vert m; Antivert; Bonamine; Chiclida; RuVertM; D Vert; Bonine; Agyrax; D-Vert; DVert

数据库引用编号

22 个数据库交叉引用编号

ChEBI: CHEBI:6709
KEGG: C07116
KEGGdrug: D81963
KEGGdrug: D08163
PubChem: 4034
HMDB: HMDB0014875
Metlin: METLIN43237
DrugBank: DB00737
ChEMBL: CHEMBL1623
Wikipedia: Meclizine
MeSH: Meclizine
chemspider: 3894
CAS: 569-65-3
MoNA: EQ308402
MoNA: EQ308406
MoNA: EQ308401
MoNA: EQ308404
MoNA: EQ308405
MoNA: EQ308403
PMhub: MS000002693
PubChem: 9327
NIKKAJI: J6.532C

分类词条

Diphenylmethanes

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Juli Liu, Yucheng Zhang, Lei Han, Shuai Guo, Shiyong Wu, Emma Helen Doud, Cheng Wang, Hanying Chen, Michael Rubart-von der Lohe, Jun Wan, Lei Yang. Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes. Stem cell reports. 2022 03; 17(3):522-537. doi: 10.1016/j.stemcr.2022.01.014. [PMID: 35180394]
Fulin Liu, Jin Zhou, Juanjuan Guo, Wen Huang, Wei Zhang, Hui Wang. Prenatal ethanol exposure increases maternal bile acids through placental transport pathway. Toxicology. 2021 06; 458(?):152848. doi: 10.1016/j.tox.2021.152848. [PMID: 34217791]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Faaiza Qazi, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Fahad Siddiqui, Muhammad Iqbal Nasiri, Kamran Ahmed, Iyad Naeem Muhammad, Farrukh Rafiq Ahmed. QbD based Eudragit coated Meclizine HCl immediate and extended release multiparticulates: formulation, characterization and pharmacokinetic evaluation using HPLC-Fluorescence detection method. Scientific reports. 2020 09; 10(1):14765. doi: 10.1038/s41598-020-71751-y. [PMID: 32913337]
Prachi Raikar, Bannimath Gurupadayya, Subhankar P Mandal, Rishitha Narhari, Sripuram Subramanyam, Gunnam Srinivasu, Surulivel Rajan, Matcha Saikumar, Sairam Koganti. Bioanalytical chiral chromatographic technique and docking studies for enantioselective separation of meclizine hydrochloride: Application to pharmacokinetic study in rabbits. Chirality. 2020 08; 32(8):1091-1106. doi: 10.1002/chir.23241. [PMID: 32567097]
Hiroshi Kitoh, Masaki Matsushita, Kenichi Mishima, Tadashi Nagata, Yasunari Kamiya, Kohei Ueda, Yachiyo Kuwatsuka, Hiroshi Morikawa, Yasuhiro Nakai, Naoki Ishiguro. Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia. PloS one. 2020; 15(4):e0229639. doi: 10.1371/journal.pone.0229639. [PMID: 32282831]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Girish G Ariga, Praveen N Naik, Sharanappa T Nandibewoor, Shivamurti A Chimatadar. Quenching of fluorescence by meclizine, a probe study for structural and conformational changes in human serum albumin. Journal of biomolecular structure & dynamics. 2017 Nov; 35(14):3161-3175. doi: 10.1080/07391102.2016.1245159. [PMID: 27767393]
Faaiza Qazi, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Muhammad Iqbal Nasiri, Kamran Ahmed, Mansoor Ahmad. Lipids bearing extruded-spheronized pellets for extended release of poorly soluble antiemetic agent-Meclizine HCl. Lipids in health and disease. 2017 Apr; 16(1):75. doi: 10.1186/s12944-017-0466-x. [PMID: 28403892]
Seiji Kishi, Gabriela Campanholle, Vishal M Gohil, Fabiana Perocchi, Craig R Brooks, Ryuji Morizane, Venkata Sabbisetti, Takaharu Ichimura, Vamsi K Mootha, Joseph V Bonventre. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Sep; 2(9):1090-101. doi: 10.1016/j.ebiom.2015.07.035. [PMID: 26501107]
Gerard A Rongen. High Dose Meclizine Prevents Renal Ischemia-Reperfusion Injury in Healthy Male Mice. EBioMedicine. 2015 Sep; 2(9):1012-3. doi: 10.1016/j.ebiom.2015.09.016. [PMID: 26501091]
Masaki Matsushita, Satoru Hasegawa, Hiroshi Kitoh, Kensaku Mori, Bisei Ohkawara, Akihiro Yasoda, Akio Masuda, Naoki Ishiguro, Kinji Ohno. Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene. Endocrinology. 2015 Feb; 156(2):548-54. doi: 10.1210/en.2014-1914. [PMID: 25456072]
M Sandeep, Jose M Alvin. Prenatal and developmental toxicity study of meclizine and caffeine combination in female albino Wistar rats. Indian journal of experimental biology. 2014 Dec; 52(12):1165-72. doi: . [PMID: 25651609]
Zhijun Wang, Benjamin Lee, Daniel Pearce, Shuai Qian, Yanfeng Wang, Qizhi Zhang, Moses S S Chow. Meclizine metabolism and pharmacokinetics: formulation on its absorption. Journal of clinical pharmacology. 2012 Sep; 52(9):1343-9. doi: 10.1177/0091270011414575. [PMID: 21903894]
Zhijun Wang, Shuai Qian, Qizhi Zhang, Moses S S Chow. Quantification of meclizine in human plasma by high performance liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Jan; 879(1):95-9. doi: 10.1016/j.jchromb.2010.11.022. [PMID: 21163711]
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M A Martins, P M Silva, M G Henriques, R S Cordeiro, F M Corrêa. Plasmodium berghei-infected mice: lack of effect of meclizine and cimetidine on the development of pulmonary oedema. Annals of tropical medicine and parasitology. 1986 Oct; 80(5):491-9. doi: 10.1080/00034983.1986.11812055. [PMID: 2888439]
J P Chovan, R P Klett, N Rakieten. Comparison of meclizine levels in the plasma of rats and dogs after intranasal, intravenous, and oral administration. Journal of pharmaceutical sciences. 1985 Oct; 74(10):1111-3. doi: 10.1002/jps.2600741022. [PMID: 4078711]
H G Fouda, F C Falkner, D C Hobbs, E W Luther. Selected ion monitoring assay for meclizine in human plasma. Biomedical mass spectrometry. 1978 Aug; 5(8):491-4. doi: 10.1002/bms.1200050806. [PMID: 687782]
F S Hom, W R Ebert. Determination of meclizine hydrochloride by ion-pair extraction with methyl orange. Journal of pharmaceutical sciences. 1977 May; 66(5):710-3. doi: 10.1002/jps.2600660526. [PMID: 17714]
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