Minocycline (BioDeep_00000002440)

 

Secondary id: BioDeep_00000408857

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

化学式: C23H27N3O7 (457.1849)
中文名称: 米诺环素
谱图信息: 最多检出来源 Viridiplantae(plant) 23.08%

分子结构信息

SMILES: CN(C)c(c4)c(C3)c(c(O)c4)C(=O)C(C32)=C(O)C(O)(C(=O)1)C(C2)C(N(C)C)C(O)=C(C(N)=O)1
InChI: InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1

描述信息

Minocycline is only found in individuals that have used or taken this drug. It is a tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections. [PubChem]Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.
A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AB - Antiinfectives and antiseptics for local oral treatment
D - Dermatologicals > D10 - Anti-acne preparations > D10A - Anti-acne preparations for topical use > D10AF - Antiinfectives for treatment of acne
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01A - Tetracyclines > J01AA - Tetracyclines
C784 - Protein Synthesis Inhibitor > C1595 - Tetracycline Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3205
KEIO_ID M159; [MS3] KO009052
KEIO_ID M159; [MS2] KO009051
KEIO_ID M159

同义名列表

9 个代谢物同义名

(4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 7-Dimethylamino-6-demethyl-6-deoxytetracycline; 4-Epi Minocycline; Minociclinum; Minociclina; Minocycline; Minomycin; MINO; Minocycline



数据库引用编号

58 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ALB, CA1, CACNA1C, CASP1, EGFR, GFAP, HMGB1, MAPK14, NLRP3, PIK3CA, PTGS2, STAT3, VEGFA
Peripheral membrane protein 2 HMGB1, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 EGFR, PTGS2
Nucleus 9 ALB, EGFR, FOS, HMGB1, MAPK14, NLRP3, PARP1, STAT3, VEGFA
cytosol 11 ALB, CA1, CASP1, FOS, GFAP, GPT, MAPK14, NLRP3, PARP1, PIK3CA, STAT3
dendrite 1 CACNA1C
nuclear body 1 PARP1
centrosome 1 ALB
nucleoplasm 5 FOS, HMGB1, MAPK14, PARP1, STAT3
RNA polymerase II transcription regulator complex 2 FOS, STAT3
Cell membrane 6 CACNA1C, CASP1, CD8A, EGFR, HMGB1, ITGAM
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 CACNA1C
Golgi apparatus membrane 1 NLRP3
Synapse 1 C1QA
cell junction 1 EGFR
cell surface 4 EGFR, HMGB1, ITGAM, VEGFA
glutamatergic synapse 3 C1QA, EGFR, MAPK14
Golgi apparatus 2 ALB, VEGFA
Golgi membrane 3 EGFR, INS, NLRP3
postsynapse 1 C1QA
Cytoplasm, cytosol 2 NLRP3, PARP1
endosome 2 EGFR, HMGB1
plasma membrane 8 CACNA1C, CASP1, CD8A, EGFR, HMGB1, ITGAM, PIK3CA, STAT3
Membrane 6 CACNA1C, EGFR, ITGAM, NLRP3, PARP1, VEGFA
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
extracellular exosome 4 ALB, CA1, GPT, ITGAM
endoplasmic reticulum 6 ALB, FOS, HMGB1, NLRP3, PTGS2, VEGFA
extracellular space 6 ALB, EGFR, HMGB1, INS, ITGAM, VEGFA
perinuclear region of cytoplasm 2 EGFR, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 3 MAPK14, NLRP3, PARP1
protein-containing complex 5 ALB, CASP1, EGFR, PARP1, PTGS2
Microsome membrane 1 PTGS2
postsynaptic density 1 CACNA1C
Single-pass type I membrane protein 3 CD8A, EGFR, ITGAM
Secreted 6 ALB, C1QA, HMGB1, INS, NLRP3, VEGFA
extracellular region 8 ALB, C1QA, CD8A, HMGB1, INS, MAPK14, NLRP3, VEGFA
astrocyte end-foot 1 GFAP
[Isoform 2]: Secreted 1 CD8A
Extracellular side 1 HMGB1
anchoring junction 1 ALB
transcription regulator complex 2 PARP1, STAT3
nuclear membrane 1 EGFR
external side of plasma membrane 2 CD8A, ITGAM
Secreted, extracellular space, extracellular matrix 1 VEGFA
T-tubule 1 CACNA1C
perikaryon 1 CACNA1C
Z disc 1 CACNA1C
nucleolus 2 CASP1, PARP1
Cell membrane, sarcolemma 1 CACNA1C
Membrane raft 2 EGFR, ITGAM
focal adhesion 1 EGFR
microtubule 1 CASP1
extracellular matrix 1 VEGFA
collagen trimer 1 C1QA
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 C1QA
secretory granule 1 VEGFA
intermediate filament 1 GFAP
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 2 CASP1, NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 2 CD8A, EGFR
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 3 FOS, PARP1, STAT3
cell projection 1 GFAP
Chromosome 2 HMGB1, PARP1
centriole 1 ALB
Nucleus, nucleolus 1 PARP1
spindle pole 2 ALB, MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
blood microparticle 1 ALB
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
Endomembrane system 1 NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
monoatomic ion channel complex 1 CACNA1C
Cell projection, dendrite 1 CACNA1C
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
cell body 1 GFAP
intermediate filament cytoskeleton 1 GFAP
basal plasma membrane 1 EGFR
Cell membrane, sarcolemma, T-tubule 1 CACNA1C
synaptic membrane 1 EGFR
plasma membrane raft 2 CD8A, ITGAM
ficolin-1-rich granule lumen 2 HMGB1, MAPK14
secretory granule lumen 3 HMGB1, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, INS, PTGS2
nuclear matrix 1 FOS
transcription repressor complex 1 HMGB1
platelet alpha granule lumen 2 ALB, VEGFA
voltage-gated calcium channel complex 1 CACNA1C
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 CACNA1C
AIM2 inflammasome complex 1 CASP1
clathrin-coated endocytic vesicle membrane 1 EGFR
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
protein-DNA complex 2 FOS, PARP1
canonical inflammasome complex 1 CASP1
[Isoform 1]: Cell membrane 1 CD8A
condensed chromosome 1 HMGB1
site of DNA damage 1 PARP1
integrin complex 1 ITGAM
cytoplasmic side of lysosomal membrane 1 GFAP
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transcription factor AP-1 complex 1 FOS
T cell receptor complex 1 CD8A
complement component C1 complex 1 C1QA
complement component C1q complex 1 C1QA
extrinsic component of postsynaptic membrane 1 C1QA
extrinsic component of presynaptic membrane 1 C1QA
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
integrin alphaM-beta2 complex 1 ITGAM
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB
L-type voltage-gated calcium channel complex 1 CACNA1C


文献列表

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  • Tingting Guo, Xiaoli Sun, Jie Yang, Liying Yang, Mengying Li, Yuhang Wang, Hongmei Jiao, Guocai Li. Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro. BMC microbiology. 2022 09; 22(1):215. doi: 10.1186/s12866-022-02629-4. [PMID: 36089583]
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  • Majid Shokoohi, Arash Khaki, Ayda Roudi Rasht Abadi, Linda MohammadZadeh Boukani, Sepideh Hassanpour Khodaie, Hossein Kalarestaghi, Amir Afshin Khaki, Maryam Moghimian, Hamid Reza Niazkar, Hamed Shoorei. Minocycline can reduce testicular apoptosis related to varicocele in male rats. Andrologia. 2022 May; 54(4):e14375. doi: 10.1111/and.14375. [PMID: 35266181]
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  • Murugan Thulasi Meenu, Grace Kaul, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Cudraflavone C from Artocarpus hirsutus as a Promising Inhibitor of Pathogenic, Multidrug-Resistant S. aureus, Persisters, and Biofilms: A New Insight into a Rational Explanation of Traditional Wisdom. Journal of natural products. 2021 10; 84(10):2700-2708. doi: 10.1021/acs.jnatprod.1c00578. [PMID: 34546736]
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  • Haoqing Wu, Manli Qi, Huiping Wang, Quanzhong Liu, Yuanjun Liu. Efficacy of minocycline in the treatment of early syphilis. International journal of STD & AIDS. 2021 06; 32(7):648-653. doi: 10.1177/0956462420984695. [PMID: 33496202]
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  • Yuan-Kun Zheng, Bao-Jun Su, Ya-Qi Wang, Heng-Shan Wang, Hai-Bing Liao, Dong Liang. New Tyramine- and Aporphine-Type Alkamides with NO Release Inhibitory Activities from Piper puberulum. Journal of natural products. 2021 04; 84(4):1316-1325. doi: 10.1021/acs.jnatprod.1c00055. [PMID: 33822610]
  • Chien-Ning Hsu, Julie Y H Chan, Kay L H Wu, Hong-Ren Yu, Wei-Chia Lee, Chih-Yao Hou, You-Lin Tain. Altered Gut Microbiota and Its Metabolites in Hypertension of Developmental Origins: Exploring Differences between Fructose and Antibiotics Exposure. International journal of molecular sciences. 2021 Mar; 22(5):. doi: 10.3390/ijms22052674. [PMID: 33800916]
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  • Thomas P Lodise, Scott Van Wart, Zoe M Sund, Adam M Bressler, Akram Khan, Amy T Makley, Yasir Hamad, Robert A Salata, Fernanda P Silveira, Matthew D Sims, Badih A Kabchi, Mohamed A Saad, Carrie Brown, Randolph E Oler, Vance Fowler, Richard G Wunderink. Pharmacokinetic and Pharmacodynamic Profiling of Minocycline for Injection following a Single Infusion in Critically Ill Adults in a Phase IV Open-Label Multicenter Study (ACUMIN). Antimicrobial agents and chemotherapy. 2021 02; 65(3):. doi: 10.1128/aac.01809-20. [PMID: 33168615]
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