Notopterol (BioDeep_00000000237)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((5-hydroxy-3,7-dimethyl-2,6-octadienyl)oxy)-, (E)-

化学式: C21H22O5 (354.1467)
中文名称: 羌活醇
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 72.37%

分子结构信息

SMILES: CC(=CC(CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C)O)C
InChI: InChI=1S/C21H22O5/c1-13(2)10-15(22)11-14(3)6-8-25-21-16-4-5-20(23)26-19(16)12-18-17(21)7-9-24-18/h4-7,9-10,12,15,22H,8,11H2,1-3H3/b14-6+

描述信息

Notopterol is a furanocoumarin.
Notopterol is a natural product found in Hansenia forbesii and Hansenia weberbaueriana with data available.
Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML)[1].
Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML)[1].

同义名列表

7 个代谢物同义名

7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((5-hydroxy-3,7-dimethyl-2,6-octadienyl)oxy)-, (E)-; (E)-4-[(5-Hydroxy-3,7-dimethyl-2,6-octadien-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one; (E)-4-((5-Hydroxy-3,7-dimethylocta-2,6-dien-1-yl)oxy)-7H-furo[3,2-g]chromen-7-one; 4-[(2E)-5-hydroxy-3,7-dimethylocta-2,6-dienoxy]furo[3,2-g]chromen-7-one; Notopterol; BCP30866; Notopterol



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, CAT, CCND1, CDK4, CYP3A4, JAK2, JAK3, NFE2L2, PIK3CA, PIK3R6, PTGS2, SOD1, SOX2, STAT3
Peripheral membrane protein 5 ACHE, JAK2, JAK3, PIK3R6, PTGS2
Endosome membrane 1 BACE1
Endoplasmic reticulum membrane 3 CYP3A4, HMOX1, PTGS2
Nucleus 11 ACHE, AKT1, CCND1, CDK4, HMOX1, JAK2, JUN, NFE2L2, SOD1, SOX2, STAT3
cytosol 13 AKT1, CAT, CCND1, CDK4, HMOX1, JAK2, JAK3, NFE2L2, PIK3CA, PIK3R6, SOD1, SOX2, STAT3
dendrite 1 BACE1
trans-Golgi network 1 BACE1
centrosome 2 CCND1, NFE2L2
nucleoplasm 10 AKT1, CCND1, CDK4, HMOX1, JAK2, JUN, NFE2L2, SOD1, SOX2, STAT3
RNA polymerase II transcription regulator complex 3 JUN, NFE2L2, STAT3
Cell membrane 5 ACHE, AKT1, BACE1, PIK3R6, TNF
Cytoplasmic side 1 HMOX1
lamellipodium 2 AKT1, PIK3CA
Cell projection, axon 1 BACE1
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 3 ACHE, BACE1, TNF
glutamatergic synapse 2 AKT1, JAK2
Golgi apparatus 3 ACHE, BACE1, NFE2L2
neuromuscular junction 1 ACHE
neuronal cell body 3 BACE1, SOD1, TNF
postsynapse 2 AKT1, JAK2
synaptic vesicle 1 BACE1
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 BACE1
endosome 2 BACE1, JAK3
plasma membrane 10 ACHE, AKT1, BACE1, JAK2, JAK3, NFE2L2, PIK3CA, PIK3R6, STAT3, TNF
Membrane 9 ACHE, AKT1, BACE1, CAT, CYP3A4, HMOX1, JAK2, JAK3, PIK3R6
axon 1 BACE1
caveola 2 JAK2, PTGS2
extracellular exosome 2 CAT, SOD1
endoplasmic reticulum 3 BACE1, HMOX1, PTGS2
extracellular space 5 ACHE, HMOX1, IL6, SOD1, TNF
perinuclear region of cytoplasm 3 ACHE, HMOX1, PIK3CA
bicellular tight junction 2 CCND1, CDK4
intercalated disc 1 PIK3CA
mitochondrion 2 CAT, SOD1
protein-containing complex 4 AKT1, CAT, PTGS2, SOD1
intracellular membrane-bounded organelle 2 CAT, CYP3A4
Microsome membrane 2 CYP3A4, PTGS2
Single-pass type I membrane protein 1 BACE1
Secreted 2 ACHE, IL6
extracellular region 5 ACHE, CAT, IL6, SOD1, TNF
cytoplasmic side of plasma membrane 2 JAK2, JAK3
mitochondrial outer membrane 1 HMOX1
hippocampal mossy fiber to CA3 synapse 1 BACE1
mitochondrial matrix 2 CAT, SOD1
Extracellular side 1 ACHE
transcription regulator complex 4 CDK4, JUN, SOX2, STAT3
Nucleus membrane 2 CCND1, CDK4
nuclear membrane 2 CCND1, CDK4
external side of plasma membrane 1 TNF
multivesicular body 1 BACE1
cytoplasmic vesicle 1 SOD1
microtubule cytoskeleton 1 AKT1
nucleolus 1 CDK4
axon cytoplasm 1 SOD1
Early endosome 1 BACE1
cell-cell junction 1 AKT1
recycling endosome 2 BACE1, TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 3 BACE1, JAK2, TNF
focal adhesion 2 CAT, JAK2
spindle 1 AKT1
Peroxisome 2 CAT, SOD1
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 2 AKT1, SOD1
nuclear speck 1 SOX2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
dendrite cytoplasm 1 SOD1
Late endosome 1 BACE1
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 5 CDK4, JUN, NFE2L2, SOX2, STAT3
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
cytoskeleton 2 JAK2, JAK3
Golgi apparatus, trans-Golgi network 1 BACE1
nuclear chromosome 1 JUN
Lipid-anchor, GPI-anchor 1 ACHE
Endomembrane system 3 BACE1, JAK2, JAK3
endosome lumen 1 JAK2
Cytoplasmic vesicle membrane 1 BACE1
Cell projection, dendrite 1 BACE1
Nucleus speckle 1 SOX2
euchromatin 2 JAK2, JUN
side of membrane 1 ACHE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 3 BACE1, IL6, PTGS2
transcription repressor complex 1 CCND1
phosphatidylinositol 3-kinase complex 2 PIK3CA, PIK3R6
phosphatidylinositol 3-kinase complex, class IA 2 PIK3CA, PIK3R6
Single-pass type IV membrane protein 1 HMOX1
extrinsic component of cytoplasmic side of plasma membrane 2 JAK2, JAK3
synaptic cleft 1 ACHE
protein-DNA complex 1 NFE2L2
extrinsic component of plasma membrane 2 JAK2, JAK3
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, CDK4
transcription factor AP-1 complex 1 JUN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
cyclin D1-CDK4 complex 2 CCND1, CDK4
cyclin D2-CDK4 complex 1 CDK4
cyclin D3-CDK4 complex 1 CDK4
[Isoform H]: Cell membrane 1 ACHE
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 2 PIK3CA, PIK3R6
Golgi-associated vesicle lumen 1 BACE1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jianpeng Zhou, Peilei Shi, Rui Ma, Xudong Xie, Lei Zhao, Jun Wang. Notopterol Inhibits the NF-κB Pathway and Activates the PI3K/Akt/Nrf2 Pathway in Periodontal Tissue. Journal of immunology (Baltimore, Md. : 1950). 2023 Oct; ?(?):. doi: 10.4049/jimmunol.2200727. [PMID: 37819772]
  • Qiong Wang, Xin Zhou, Long Yang, Yongjian Zhao, Zhihuan Chew, Jun Xiao, Chang Liu, Xin Zheng, Yuxiao Zheng, Qi Shi, Qianqian Liang, Yongjun Wang, Hongyan Wang. The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis. Cell reports. 2020 09; 32(11):108158. doi: 10.1016/j.celrep.2020.108158. [PMID: 32937124]
  • Liangzhao Cai, Jia Lun, Yanru Liu, Xingjie Guo. Separation and quantitation of notopterol enantiomers in notopterygii rhizoma et radix using solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2020 Jul; 186(?):113255. doi: 10.1016/j.jpba.2020.113255. [PMID: 32278253]
  • Yao Fu, Xiaoxiao Tian, Lingling Han, Yilin Li, Ying Peng, Jiang Zheng. Mechanism-based inactivation of cytochrome P450 2D6 by Notopterol. Chemico-biological interactions. 2020 May; 322(?):109053. doi: 10.1016/j.cbi.2020.109053. [PMID: 32198085]
  • Qinwan Huang, Lin Wang, Qian Ran, Jin Wang, Chengqiang Wang, Hui He, Li Li, Hongyi Qi. Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells. Drug design, development and therapy. 2019; 13(?):1927-1940. doi: 10.2147/dddt.s189969. [PMID: 31239643]
  • E Okuyama, S Nishimura, S Ohmori, Y Ozaki, M Satake, M Yamazaki. Analgesic component of Notopterygium incisum Ting. Chemical & pharmaceutical bulletin. 1993 May; 41(5):926-9. doi: 10.1248/cpb.41.926. [PMID: 8339339]