Aripiprazole (BioDeep_00000002331)
human metabolite Chemicals and Drugs
代谢物信息卡片
7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one
化学式: C23H27Cl2N3O2 (447.148)
中文名称: 阿立哌唑
谱图信息:
最多检出来源 Homo sapiens(not specific) 12.69%
Reviewed
Last reviewed on 2024-09-14.
Cite this Page
Aripiprazole. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/aripiprazole (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000002331). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(CCOc1ccc2CCC(=O)Nc2c1)CN1CCN(CC1)c1cccc(c1Cl)Cl
InChI: InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
描述信息
Aripiprazole is a warning has gone out recently because of this drugs name. The -prazole ending of this drug name makes this drug sound like it is one of the proton pump inhibitors (such as omeprazole, pantoprazole, lansoprazole) which are used in treating peptic ulcer disease. However, aripiprazole and these drugs are in an entirely different class of drugs altogether and confusing the two can lead to some unnecessary side effects. Aripiprazole is the sixth and most recent of the atypical antipsychotic medications to be approved by the Food and Drug Administration (FDA) for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder. Aripiprazole appears to mediate its antipsychotic effects primarily by partial agonism at the Dopamine 2 (D2)receptor.
Aripiprazole is an atypical antipsychotic and antidepressant used in the treatment of schizophrenia, bipolar disorder, and clinical depression. OPC is found in chinese cinnamon.
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics
Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19[1][2][3][4].
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:31236
- KEGG: C12564
- PubChem: 60795
- HMDB: HMDB0005042
- Metlin: METLIN58290
- DrugBank: DB01238
- ChEMBL: CHEMBL1112
- Wikipedia: Aripiprazole
- MeSH: Aripiprazole
- foodb: FDB004879
- chemspider: 54790
- CAS: 129722-12-9
- PMhub: MS000002363
- PubChem: 582954
- PDB-CCD: 9SC
- NIKKAJI: J573.417G
- RefMet: Aripiprazole
- medchemexpress: HY-14546
- KNApSAcK: 31236
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Diane Merino, Alexandre O Gérard, Alexandre Destere, Haitam Saidessalam, Florence Askenazy, François Montastruc, Milou-Daniel Drici, Susanne Thümmler. Cardiac and metabolic safety profile of antipsychotics in youths: A WHO safety database analysis.
Psychiatry research.
2024 Apr; 334(?):115786. doi:
10.1016/j.psychres.2024.115786. [PMID: 38387164] - Mengjia Ji, Junfei Feng, Guirong Liu. Efficacy and safety of aripiprazole or bupropion augmentation and switching in patients with treatment-resistant depression or major depressive disorder: A systematic review and meta-analysis of randomized controlled trials.
PloS one.
2024; 19(4):e0299020. doi:
10.1371/journal.pone.0299020. [PMID: 38669232] - Wei Su, Dan Zhao, Hongmei Zhao, Wanhong Zheng, Wangxin Zhang. A 28-Year-Old Man with Obsessive-Compulsive Disorder, Post-Traumatic Stress Disorder, and Dissociative Identity Disorder Responding to Aripiprazole Augmentation of Clomipramine Combined with Psychoeducation and Exposure and Response Prevention.
The American journal of case reports.
2023 Dec; 24(?):e941534. doi:
10.12659/ajcr.941534. [PMID: 38100391] - Zhe Lu, Yuyanan Zhang, Yaoyao Sun, Yundan Liao, Zhewei Kang, Xiaoyang Feng, Hao Yan, Lifang Wang, Tianlan Lu, Dai Zhang, Weihua Yue. Therapeutic Outcomes Wide Association Scan of different antipsychotics in patients with schizophrenia: randomized clinical trials and multi-ancestry validation.
Psychiatry and clinical neurosciences.
2023 May; ?(?):. doi:
10.1111/pcn.13567. [PMID: 37210704] - Jingda Cai, Li Li, Tiannan Shao, Mengxi Sun, Weiyan Wang, Peng Xie, Xiaoyi Wang, Ye Yang, Yujun Long, Dongyu Kang, Jingmei Xiao, Yuhan Su, Xingjie Peng, Yuyan Huang, Menghui Gao, Qiongqiong Wu, Chuhan Song, Furu Liu, Ping Shao, Jianjun Ou, Yidong Shen, Jing Huang, Renrong Wu. Relapse in patients with schizophrenia and amisulpride-induced hyperprolactinemia or olanzapine-induced metabolic disturbance after switching to other antipsychotics.
Psychiatry research.
2023 Mar; 322(?):115138. doi:
10.1016/j.psychres.2023.115138. [PMID: 36871411] - Milica Vranic, Fozia Ahmed, Susanne Hetty, Assel Sarsenbayeva, Vitor Ferreira, Giovanni Fanni, Ángela M Valverde, Jan W Eriksson, Maria J Pereira. Effects of the second-generation antipsychotic drugs aripiprazole and olanzapine on human adipocyte differentiation.
Molecular and cellular endocrinology.
2023 Feb; 561(?):111828. doi:
10.1016/j.mce.2022.111828. [PMID: 36526026] - Javier Vázquez-Bourgon, Víctor Ortiz-García de la Foz, Marcos Gómez-Revuelta, Jacqueline Mayoral-van Son, María Juncal-Ruiz, Nathalia Garrido-Torres, Benedicto Crespo-Facorro. Aripiprazole and Risperidone Present Comparable Long-Term Metabolic Profiles: Data From a Pragmatic Randomized Controlled Trial in Drug-Naïve First-Episode Psychosis.
The international journal of neuropsychopharmacology.
2022 10; 25(10):795-806. doi:
10.1093/ijnp/pyac033. [PMID: 35641112] - Marta Balog, Allison Anderson, Thiago C Genaro-Mattos, Zeljka Korade, Karoly Mirnics. Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain.
Journal of lipid research.
2022 08; 63(8):100249. doi:
10.1016/j.jlr.2022.100249. [PMID: 35839864] - Arnim Johannes Gaebler, Michelle Finner-Prével, Sarah Lammertz, Sabrina Schaffrath, Patrick Eisner, Felix Stöhr, Erik Röcher, Lina Winkler, Peter Kaleta, Laura Lenzen, Marc Augustin, Jana Hovancakova, Lara Schwemmer, Eva Stormanns, Fatih Keskin, Frederik Hendricks, Michael Paulzen, Gerhard Gründer, Frank Schneider, Klaus Mathiak. The negative impact of vitamin D on antipsychotic drug exposure may counteract its potential benefits in schizophrenia.
British journal of clinical pharmacology.
2022 07; 88(7):3193-3200. doi:
10.1111/bcp.15223. [PMID: 35380747] - Moeno Kadoguchi, Hiroshi Arakawa, Ryokichi Honda, Kazuki Hotta, Yoshiyuki Shirasaka, Yoshiharu Deguchi, Ikumi Tamai. Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening.
Pharmaceutical research.
2022 Jul; 39(7):1549-1559. doi:
10.1007/s11095-022-03223-z. [PMID: 35314999] - Theocharis Chr Kyziridis. [Clinical pharmacokinetics and pharmaceutical forms of long-acting injectable antipsychotics].
Psychiatrike = Psychiatriki.
2022 Jun; 33(2):139-148. doi:
10.22365/jpsych.2021.035. [PMID: 34390562] - Roger W Sommi, Bhaskar Rege, Angela Wehr, Sejal Faldu, Yangchun Du, Peter J Weiden. Aripiprazole Lauroxil Dosing Regimens: Understanding Dosage Strengths and Injection Intervals.
CNS spectrums.
2022 06; 27(3):262-267. doi:
10.1017/s1092852920002072. [PMID: 33267924] - Hae-Jung Yang, Seung-Gon Kim, Eun Hyun Seo, Hyung-Jun Yoon. Amisulpride withdrawal akathisia responding to aripiprazole with propranolol in first-onset psychosis: a case report.
BMC psychiatry.
2022 01; 22(1):74. doi:
10.1186/s12888-022-03721-9. [PMID: 35093063] - Xueting Guo, Maolian Zhang, Yibin Guo, Hao Liu, Bing Yang, Jingxin Gou, Tian Yin, Yu Zhang, Haibing He, Dongchun Liu, Xing Tang. Impact of jet pulverization and wet milling techniques on properties of aripiprazole long-acting injection and absorption mechanism research in vivo.
International journal of pharmaceutics.
2022 Jan; 612(?):121300. doi:
10.1016/j.ijpharm.2021.121300. [PMID: 34793936] - N V Baymeeva, I I Miroshnichenko, A I Platova, D V Tikhonov, V G Kaleda. [Therapeutic drug monitoring of aripiprazole as part of the individualization of the pharmacotherapy of schizophrenia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2022; 122(1):98-103. doi:
10.17116/jnevro202212201198. [PMID: 35175709] - Jarosław Sobiś, Łukasz Kunert, Monika Rykaczewska-Czerwińska, Elżbieta Świętochowska, Piotr Gorczyca. The effect of aripiprazole on leptin levels of patients with chronic schizophrenia and a comparison of leptin, acute phase protein, and cytokine levels with regard to body mass and body composition indexes.
Endokrynologia Polska.
2022; 73(1):35-42. doi:
10.5603/ep.a2021.0110. [PMID: 35381103] - Lisa Alina Kneller, Pablo Zubiaur, Dora Koller, Francisco Abad-Santos, Georg Hempel. Influence of CYP2D6 Phenotypes on the Pharmacokinetics of Aripiprazole and Dehydro-Aripiprazole Using a Physiologically Based Pharmacokinetic Approach.
Clinical pharmacokinetics.
2021 12; 60(12):1569-1582. doi:
10.1007/s40262-021-01041-x. [PMID: 34125422] - Kenshiro Hirata, Tokunori Ikeda, Hiroshi Watanabe, Toru Maruyama, Motoko Tanaka, Victor Tuan Giam Chuang, Yuji Uchida, Keiki Sakurama, Koji Nishi, Keishi Yamasaki, Masaki Otagiri. The Binding of Aripiprazole to Plasma Proteins in Chronic Renal Failure Patients.
Toxins.
2021 11; 13(11):. doi:
10.3390/toxins13110811. [PMID: 34822595] - Ditte Rudå, Karsten Gjessing Jensen, Marie Stentebjerg Decara, Dea Gowers Klauber, Birgitte Fagerlund, Jens Richardt Møllegaard, Kristian Linnet, Thomas Werge, Christoph U Correll, Anders Fink-Jensen, Gesche Jürgens, Anne Katrine Pagsberg. CYP2D6 Genotyping and Antipsychotic-Associated Extrapyramidal Adverse Effects in a Randomized Trial of Aripiprazole Versus Quetiapine Extended Release in Children and Adolescents, Aged 12-17 Years, With First Episode Psychosis.
Journal of clinical psychopharmacology.
2021 Nov; 41(6):667-672. doi:
10.1097/jcp.0000000000001490. [PMID: 34735099] - Jana Osacka, Romana Koprdova, Andrej Tillinger, Zdenko Pirnik, Alexander Kiss. Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress.
Endocrine regulations.
2021 Sep; 55(3):153-162. doi:
10.2478/enr-2021-0016. [PMID: 34523299] - Minami Tasaki, Norio Yasui-Furukori, Saaya Yokoyama, Masataka Shinozaki, Norio Sugawara, Kazutaka Shimoda. Hypoprolactinemia and hyperprolactinemia in male schizophrenia patients treated with aripiprazole and risperidone and their relationships with testosterone levels.
Neuropsychopharmacology reports.
2021 09; 41(3):379-384. doi:
10.1002/npr2.12190. [PMID: 34189861] - Yuan-Yuan Zhang, Xie-Hai Zhou, Feng Shan, Jun Liang. Infection is associated with elevated serum concentrations of antipsychotic drugs.
International clinical psychopharmacology.
2021 09; 36(5):264-267. doi:
10.1097/yic.0000000000000366. [PMID: 34030168] - Jin Xiang, Nan Xu, Xueyan Wang, Songfan Li, Qin Yu, Maozhi Liang, Feng Nan, Shiqing Shu, Rui Yan, Yuqi Zhu, Linchuan Liao. Bioequivalence of 2 Aripiprazole Orally Disintegrating Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions.
Clinical pharmacology in drug development.
2021 08; 10(8):840-849. doi:
10.1002/cpdd.954. [PMID: 34105265] - Minami Tasaki, Norio Yasui-Furukori, Kazuyoshi Kubo, Saaya Yokoyama, Masataka Shinozaki, Norio Sugawara, Yoshimasa Inoue, Kazutaka Shimoda. Relationship of Prolactin Concentrations to Steady-State Plasma Concentrations of Aripiprazole in Patients With Schizophrenia.
Therapeutic drug monitoring.
2021 08; 43(4):589-592. doi:
10.1097/ftd.0000000000000843. [PMID: 33235024] - Deanna L Kelly, Amy Claxton, Ilda Bidollari, Yangchun Du. Analysis of prolactin and sexual side effects in patients with schizophrenia who switched from paliperidone palmitate to aripiprazole lauroxil.
Psychiatry research.
2021 08; 302(?):114030. doi:
10.1016/j.psychres.2021.114030. [PMID: 34118485] - Aurélie Delacrétaz, Anaïs Glatard, Céline Dubath, Mehdi Gholam, Franziska Gamma, Armin von Gunten, Philippe Conus, Chin B Eap. Valproate is associated with early decrease of high-density lipoprotein cholesterol levels in the psychiatric population.
Basic & clinical pharmacology & toxicology.
2021 Jul; 129(1):26-35. doi:
10.1111/bcpt.13580. [PMID: 33733594] - Leila Alba, Cristina Coll, Sonia Sáez, Lucía Alonso, Helena Pérez, Saray Palma, Virginia Vallés, Sonia Ortiz. New-onset psychosis: A case report of brief psychosis related to COVID-19 infection.
Psychiatry research.
2021 07; 301(?):113975. doi:
10.1016/j.psychres.2021.113975. [PMID: 33990069] - Frank M C Besag, Michael J Vasey, Iffah Salim. Is Adjunct Aripiprazole Effective in Treating Hyperprolactinemia Induced by Psychotropic Medication? A Narrative Review.
CNS drugs.
2021 05; 35(5):507-526. doi:
10.1007/s40263-021-00812-1. [PMID: 33880739] - Liang Zheng, Shiwei Tang, Rui Tang, Miao Xu, Xuehua Jiang, Ling Wang. Dose Adjustment of Quetiapine and Aripiprazole for Pregnant Women Using Physiologically Based Pharmacokinetic Modeling and Simulation.
Clinical pharmacokinetics.
2021 05; 60(5):623-635. doi:
10.1007/s40262-020-00962-3. [PMID: 33251573] - Giampaolo Perna, Silvia Daccò, Alessandra Alciati, Francesco Cuniberti, Domenico De Berardis, Daniela Caldirola. Childhood maltreatment history for guiding personalized antidepressant choice in major depressive disorder: Preliminary results from a systematic review.
Progress in neuro-psychopharmacology & biological psychiatry.
2021 04; 107(?):110208. doi:
10.1016/j.pnpbp.2020.110208. [PMID: 33338557] - Peiyu Xu, Sijie Huang, Huibing Zhang, Chunyou Mao, X Edward Zhou, Xi Cheng, Icaro A Simon, Dan-Dan Shen, Hsin-Yung Yen, Carol V Robinson, Kasper Harpsøe, Bo Svensson, Jia Guo, Hualiang Jiang, David E Gloriam, Karsten Melcher, Yi Jiang, Yan Zhang, H Eric Xu. Structural insights into the lipid and ligand regulation of serotonin receptors.
Nature.
2021 04; 592(7854):469-473. doi:
10.1038/s41586-021-03376-8. [PMID: 33762731] - Verena Sichert, Hans-Peter Volz. Rapid efficacy of aripiprazole in the treatment of catatonic depression/catatonia with consideration of the drug's unique receptor profile: a case report.
Fortschritte der Neurologie-Psychiatrie.
2021 Apr; 89(4):178-181. doi:
10.1055/a-1183-3887. [PMID: 32575133] - Xiaodan Zhang, Chengquan Liu, Shuang Zhou, Ran Xie, Xu He, Zhiqi Wang, Honghong Yi, You Shu, Zining Wang, Kun Hu, Lingyue Ma, Yimin Cui, Xia Zhao, Jin Xiang. Influence of CYP2D6 gene polymorphisms on the pharmacokinetics of aripiprazole in healthy Chinese subjects.
Pharmacogenomics.
2021 03; 22(4):213-223. doi:
10.2217/pgs-2020-0134. [PMID: 33586456] - Burak Çakır, Şermin Yalın Sapmaz, Hasan Kandemir. Use of Antipsychotics: The Experiences, Views, and Monitoring Practices of Child and Adolescent Psychiatrists in Turkey.
Journal of child and adolescent psychopharmacology.
2021 02; 31(1):73-78. doi:
10.1089/cap.2020.0078. [PMID: 32614261] - Dora Koller, Susana Almenara, Gina Mejía, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Marcos Navares-Gómez, Elena Santos-Molina, Elena Pintos-Sánchez, Francisco Abad-Santos. Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics.
Advances in therapy.
2021 02; 38(2):1035-1054. doi:
10.1007/s12325-020-01566-w. [PMID: 33278020] - Rikera Taylor, Nikita Bodoukhin, Mousa Botros, Luminita Luca. Joy Journal: A Behavioral Activation Technique Used in the Treatment of Late-Life Depression Associated With Hopelessness During the COVID-19 Pandemic.
The primary care companion for CNS disorders.
2021 01; 23(1):. doi:
10.4088/pcc.20l02817. [PMID: 33411995] - Tahir Rahman, Cory Patrick, Cynthia Ma, Ginger E Nicol, Charles F Reynolds, Benoit H Mulsant, Sarah M Hartz, Michael Yingling, Eric J Lenze. Prolactin and Estrogen Levels in Postmenopausal Women Receiving Aripiprazole Augmentation Treatment for Depression.
Journal of clinical psychopharmacology.
2021 Jan; 41(1):31-35. doi:
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Biological & pharmaceutical bulletin.
2021; 44(3):437-441. doi:
10.1248/bpb.b20-00929. [PMID: 33642552] - Faruk Uguz. A New Safety Scoring System for the Use of Psychotropic Drugs During Lactation.
American journal of therapeutics.
2021 Jan; 28(1):e118-e126. doi:
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Human psychopharmacology.
2021 01; 36(1):1-12. doi:
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Journal of neural transmission (Vienna, Austria : 1996).
2020 12; 127(12):1663-1674. doi:
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Biosensors & bioelectronics.
2020 Dec; 169(?):112589. doi:
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The lancet. Psychiatry.
2020 11; 7(11):945-954. doi:
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European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2020 10; 39(?):46-55. doi:
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British journal of clinical pharmacology.
2020 10; 86(10):2051-2062. doi:
10.1111/bcp.14300. [PMID: 32250470] - Massimo Carlo Mauri, Alessandra Reggiori, Alessandro Minutillo, Gemma Franco, Chiara Di Pace, Silvia Paletta, Dario Cattaneo. Paliperidone LAI and Aripiprazole LAI Plasma Level Monitoring in the Prophylaxis of Bipolar Disorder Type I with Manic Predominance.
Pharmacopsychiatry.
2020 Sep; 53(5):209-219. doi:
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CNS drugs.
2020 09; 34(9):961-972. doi:
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Clinical neuropharmacology.
2020 Sep; 43(5):166-168. doi:
10.1097/wnf.0000000000000404. [PMID: 32947430] - Vieri Piazzini, Elisa Landucci, Matteo Urru, Alberto Chiarugi, Domenico E Pellegrini-Giampietro, Anna Rita Bilia, Maria Camilla Bergonzi. Enhanced dissolution, permeation and oral bioavailability of aripiprazole mixed micelles: In vitro and in vivo evaluation.
International journal of pharmaceutics.
2020 Jun; 583(?):119361. doi:
10.1016/j.ijpharm.2020.119361. [PMID: 32334067] - Rakesh Jain, Jonathan Meyer, Angela Wehr, Bhaskar Rege, Lisa von Moltke, Peter J Weiden. Size matters: the importance of particle size in a newly developed injectable formulation for the treatment of schizophrenia.
CNS spectrums.
2020 06; 25(3):323-330. doi:
10.1017/s1092852919000816. [PMID: 31111801] - Sheng Feng, Jeffrey R Enders, Oneka T Cummings, Erin C Strickland, Timothy McIntire, Gregory McIntire. A Dilute and Shoot LC-MS/MS Method for Antipsychotics in Urine.
Journal of analytical toxicology.
2020 May; 44(4):331-338. doi:
10.1093/jat/bkz098. [PMID: 31776574] - Domenico De Donatis, Stefano Porcelli, Alessandro Serretti, Vincenzo Florio, Claudio Volanti, Ignazio Maniscalco, Andreas Conca, Alois Saria. Serum Aripiprazole Concentrations Prehemodialysis and Posthemodialysis in a Schizophrenic Patient With Chronic Renal Failure: A Case Report.
Journal of clinical psychopharmacology.
2020 Mar; 40(2):200-202. doi:
10.1097/jcp.0000000000001178. [PMID: 32134859] - Dora Koller, Carmen Belmonte, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Francisco Abad-Santos. Effects of aripiprazole on circadian prolactin secretion related to pharmacogenetics in healthy volunteers.
Basic & clinical pharmacology & toxicology.
2020 Mar; 126(3):236-246. doi:
10.1111/bcpt.13323. [PMID: 31520576] - Ádám Kiss, Ádám Menus, Katalin Tóth, Máté Déri, Dávid Sirok, Evelyn Gabri, Ales Belic, Gábor Csukly, István Bitter, Katalin Monostory. Phenoconversion of CYP2D6 by inhibitors modifies aripiprazole exposure.
European archives of psychiatry and clinical neuroscience.
2020 Feb; 270(1):71-82. doi:
10.1007/s00406-018-0975-2. [PMID: 30604050] - Austen Yeager, Mujeeb U Shad. Aripiprazole for the Management of Antipsychotic-Induced Hyperprolactinemia A Retrospective Case Series.
The primary care companion for CNS disorders.
2020 Jan; 22(1):. doi:
10.4088/pcc.19br02536. [PMID: 31999895] - Keiki Sakurama, Koji Nishi, Victor Tuan Giam Chuang, Mai Hashimoto, Keishi Yamasaki, Masaki Otagiri. Effects of Oxidation of Human Serum Albumin on the Binding of Aripiprazole.
Biological & pharmaceutical bulletin.
2020; 43(6):1023-1026. doi:
10.1248/bpb.b20-00205. [PMID: 32475912] - Houli Li, Xiaoliang Cheng, Di Zhang, Maoyi Wang, Weihua Dong, Weiyi Feng. A UPLC-MS/MS Assay for Simultaneous Determination of Two Antipsychotics and Two Antidepressants in Human Plasma and Its Application in Clinic.
Current pharmaceutical biotechnology.
2020; 21(1):60-69. doi:
10.2174/1389201020666190830150549. [PMID: 31470784] - Tinkara Pirc Marolt, Barbara Kramar, Klara Bulc Rozman, Dušan Šuput, Irina Milisav. Aripiprazole reduces liver cell division.
PloS one.
2020; 15(10):e0240754. doi:
10.1371/journal.pone.0240754. [PMID: 33104743] - Maike Scherf-Clavel, Anne Weidner, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Pathological Concentration of C-reactive Protein is Correlated to Increased Concentrations of Quetiapine, But Not of Risperidone, Olanzapine and Aripiprazole in a Naturalistic Setting.
Pharmacopsychiatry.
2020 Jan; 53(1):30-35. doi:
10.1055/a-0869-8053. [PMID: 30913567] - Takuro Sugai, Yutaro Suzuki, Manabu Yamazaki, Norio Sugawara, Norio Yasui-Furukori, Kazutaka Shimoda, Takao Mori, Yuji Ozeki, Hiroshi Matsuda, Kurefu Okamoto, Toyoaki Sagae, Toshiyuki Someya. Lower Prolactin Levels in Patients Treated With Aripiprazole Regardless of Antipsychotic Monopharmacy or Polypharmacy.
Journal of clinical psychopharmacology.
2020 Jan; 40(1):14-17. doi:
10.1097/jcp.0000000000001158. [PMID: 31834097] - Robin Valpey, Morgan Faeder. Aripiprazole-Induced Syndrome of Inappropriate Antidiuretic Hormone Secretion: Case Report and Literature Review.
Psychosomatics.
2020 Jan; 61(1):76-80. doi:
10.1016/j.psym.2019.03.001. [PMID: 31084987] - Marit Tveito, Espen Molden, Gudrun Høiseth, Christoph U Correll, Robert Løvsletten Smith. Impact of age and CYP2D6 genetics on exposure of aripiprazole and dehydroaripiprazole in patients using long-acting injectable versus oral formulation: relevance of poor and intermediate metabolizer status.
European journal of clinical pharmacology.
2020 Jan; 76(1):41-49. doi:
10.1007/s00228-019-02768-0. [PMID: 31637453] - Assel Sarsenbayeva, Cátia M Marques-Santos, Ketan Thombare, Giada Di Nunzio, Kristina E Almby, Martin Lundqvist, Jan W Eriksson, Maria J Pereira. Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism.
Psychoneuroendocrinology.
2019 12; 110(?):104445. doi:
10.1016/j.psyneuen.2019.104445. [PMID: 31563732] - Koji Nishi, Keiki Sakurama, Yoshihiro Kobashigawa, Hiroshi Morioka, Nagiko Udo, Mai Hashimoto, Shuhei Imoto, Keishi Yamasaki, Masaki Otagiri. Interaction of Aripiprazole With Human α1-Acid Glycoprotein.
Journal of pharmaceutical sciences.
2019 12; 108(12):3911-3916. doi:
10.1016/j.xphs.2019.09.003. [PMID: 31520646] - Karsten Gjessing Jensen, Christoph U Correll, Ditte Rudå, Dea Gowers Klauber, Marie Stentebjerg Decara, Birgitte Fagerlund, Jens Richardt Møllegaard Jepsen, Frank Eriksson, Anders Fink-Jensen, Anne Katrine Pagsberg. Cardiometabolic Adverse Effects and Its Predictors in Children and Adolescents With First-Episode Psychosis During Treatment With Quetiapine-Extended Release Versus Aripiprazole: 12-Week Results From the Tolerance and Effect of Antipsychotics in Children and Adolescents With Psychosis (TEA) Trial.
Journal of the American Academy of Child and Adolescent Psychiatry.
2019 11; 58(11):1062-1078. doi:
10.1016/j.jaac.2019.01.015. [PMID: 30858012] - Tanja Veselinović, Martin Scharpenberg, Martin Heinze, Joachim Cordes, Bernd Mühlbauer, Georg Juckel, Eckart Rüther, Michael Paulzen, Ekkehard Haen, Christoph Hiemke, Jürgen Timm, Gerhard Gründer. Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Mental Well-Being in Schizophrenia: Results From the Randomized NeSSy Trial.
Journal of clinical psychopharmacology.
2019 Nov; 39(6):550-560. doi:
10.1097/jcp.0000000000001131. [PMID: 31688449] - Ashley M Beaulieu, Edward Tabasky, David N Osser. The psychopharmacology algorithm project at the Harvard South Shore Program: An algorithm for adults with obsessive-compulsive disorder.
Psychiatry research.
2019 11; 281(?):112583. doi:
10.1016/j.psychres.2019.112583. [PMID: 31600606] - Valentina Caricasole, Giuseppe Spagnolo, Ilaria Di Bernardo, Giovanna Cirnigliaro, Eleonora Piccoli, Bernardo Dell'Osso. Aripiprazole causing false positive urine amphetamine drug screen in an adult patient with bipolar disorder.
Comprehensive psychiatry.
2019 10; 94(?):152126. doi:
10.1016/j.comppsych.2019.152126. [PMID: 31518847] - M Cardinale, P J Cungi, E Meaudre. Green plasma and a blocked CRRT circuit due to drug-induced hyperlipidemia.
Intensive care medicine.
2019 09; 45(9):1305-1306. doi:
10.1007/s00134-019-05592-3. [PMID: 30888439] - Dora Koller, Pablo Zubiaur, Miriam Saiz-Rodríguez, Francisco Abad-Santos, Aneta Wojnicz. Simultaneous determination of six antipsychotics, two of their metabolites and caffeine in human plasma by LC-MS/MS using a phospholipid-removal microelution-solid phase extraction method for sample preparation.
Talanta.
2019 Jun; 198(?):159-168. doi:
10.1016/j.talanta.2019.01.112. [PMID: 30876545] - Keiki Sakurama, Koji Nishi, Shuhei Imoto, Mai Hashimoto, Teruyuki Komatsu, Yoshitsugu Morita, Kazuaki Taguchi, Masaki Otagiri, Keishi Yamasaki. Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin.
Journal of pharmaceutical sciences.
2019 05; 108(5):1890-1895. doi:
10.1016/j.xphs.2018.11.045. [PMID: 30537471] - Marin M Jukic, Robert L Smith, Tore Haslemo, Espen Molden, Magnus Ingelman-Sundberg. Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study.
The lancet. Psychiatry.
2019 May; 6(5):418-426. doi:
10.1016/s2215-0366(19)30088-4. [PMID: 31000417] - Tao Luo, Qiao-Sheng Liu, Yuan-Jian Yang, Bo Wei. Aripiprazole for the treatment of duloxetine-induced hyperprolactinemia: A case report.
Journal of affective disorders.
2019 05; 250(?):330-332. doi:
10.1016/j.jad.2019.03.006. [PMID: 30875676] - Sho Horikoshi, Itaru Miura, Mizue Ichinose, Shinnosuke Yamamoto, Masashi Ito, Kenya Watanabe, Keiko Kanno-Nozaki, Haruka Kaneko, Hirooki Yabe. Low- and high-dose aripiprazole augmentation and plasma levels of homovanillic acid in major depressive disorder: A randomized, open-label study.
Human psychopharmacology.
2019 05; 34(3):e2696. doi:
10.1002/hup.2696. [PMID: 31044463] - Jochen Gehrmann, Peter Götz Lampe. Serum Level Measurements Optimize Aripriprazole Treatment in Adolescent Patients.
Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie.
2019 May; 47(3):261-264. doi:
10.1024/1422-4917/a000637. [PMID: 30516094] - Xiaodan Zhang, Qian Xiang, Xia Zhao, Lingyue Ma, Yimin Cui. Association between aripiprazole pharmacokinetics and CYP2D6 phenotypes: A systematic review and meta-analysis.
Journal of clinical pharmacy and therapeutics.
2019 Apr; 44(2):163-173. doi:
10.1111/jcpt.12780. [PMID: 30565279] - Sarah Farwick, Magali B Hickey, Gwen Jacobs, Sejal P Faldu, Jennifer Vandiver, Peter J Weiden. Best Practices for Aripiprazole Lauroxil Administration: From Formulation Development to Injection Technique.
Journal of psychiatric practice.
2019 03; 25(2):82-90. doi:
10.1097/pra.0000000000000376. [PMID: 30849056] - Mohammad Raish, Ajaz Ahmad, Mushtaq Ahmad Ansari, Khalid M Alkharfy, Abdul Ahad, Altaf Khan, Fahad I Aljenobi, Naushad Ali, Abdullah M Al-Mohizea. Effect of sinapic acid on aripiprazole pharmacokinetics in rats: Possible food drug interaction.
Journal of food and drug analysis.
2019 01; 27(1):332-338. doi:
10.1016/j.jfda.2018.06.002. [PMID: 30648588] - María Juncal-Ruiz, Laura Riesco-Dávila, Víctor Ortiz-García de la Foz, Obdulia Martínez-Garcia, Mariluz Ramírez-Bonilla, Javier Gonzalo Ocejo-Viñals, Juan Carlos Leza, Marcos López-Hoyos, Benedicto Crespo-Facorro. Comparison of the anti-inflammatory effect of aripiprazole and risperidone in 75 drug-naïve first episode psychosis individuals: A 3 months randomized study.
Schizophrenia research.
2018 12; 202(?):226-233. doi:
10.1016/j.schres.2018.06.039. [PMID: 29941296] - Dora Koller, Carmen Belmonte, Rubin Lubomirov, Miriam Saiz-Rodríguez, Pablo Zubiaur, Manuel Román, Dolores Ochoa, Antonio Carcas, Aneta Wojnicz, Francisco Abad-Santos. Effects of aripiprazole on pupillometric parameters related to pharmacokinetics and pharmacogenetics after single oral administration to healthy subjects.
Journal of psychopharmacology (Oxford, England).
2018 11; 32(11):1212-1222. doi:
10.1177/0269881118798605. [PMID: 30251598] - Bo Pan, Jiamei Lian, Chao Deng. Chronic antipsychotic treatment differentially modulates protein kinase A- and glycogen synthase kinase 3 beta-dependent signaling pathways, N-methyl-D-aspartate receptor and γ-aminobutyric acid A receptors in nucleus accumbens of juvenile rats.
Journal of psychopharmacology (Oxford, England).
2018 11; 32(11):1252-1263. doi:
10.1177/0269881118788822. [PMID: 30136620] - Marjie L Hard, Angela Y Wehr, Yangchun Du, Peter J Weiden, David Walling, Lisa von Moltke. Pharmacokinetic Evaluation of a 1-Day Treatment Initiation Option for Starting Long-Acting Aripiprazole Lauroxil for Schizophrenia.
Journal of clinical psychopharmacology.
2018 Oct; 38(5):435-441. doi:
10.1097/jcp.0000000000000921. [PMID: 30015676] - Esther Letícia Amorim Ribeiro, Tácio de Mendonça Lima, Marcio Eduardo Bergamini Vieira, Sílvia Storpirtis, Patricia Melo Aguiar. Efficacy and safety of aripiprazole for the treatment of schizophrenia: an overview of systematic reviews.
European journal of clinical pharmacology.
2018 Oct; 74(10):1215-1233. doi:
10.1007/s00228-018-2498-1. [PMID: 29905899] - Marjie L Hard, Angela Y Wehr, Brian M Sadler, Richard J Mills, Lisa von Moltke. Population Pharmacokinetic Analysis and Model-Based Simulations of Aripiprazole for a 1-Day Initiation Regimen for the Long-Acting Antipsychotic Aripiprazole Lauroxil.
European journal of drug metabolism and pharmacokinetics.
2018 Aug; 43(4):461-469. doi:
10.1007/s13318-018-0488-4. [PMID: 29943125] - Juliana R Bastos, Katherinne M Perico, Érica L Marciano Vieira, Antônio L Teixeira, Fabiana S Machado, Aline S de Miranda, Fabrício A Moreira. Inhibition of the dopamine transporter as an animal model of bipolar disorder mania: Locomotor response, neuroimmunological profile and pharmacological modulation.
Journal of psychiatric research.
2018 07; 102(?):142-149. doi:
10.1016/j.jpsychires.2018.04.004. [PMID: 29656188] - Xiao-Jia Jiang, Fu-Xi Wu, Jian-Ping Zhang, Lei Shi, Jin-Qing Hu, Hai-Zhen Zhu, Bing Xiao, Wei-Cheng Lin, Yu-Guan Wen, De-Wei Shang. Effects of Risperidone and Aripiprazole on Serum Levels of Prolactin, Testosterone and Estradiol in Female Patients with Schizophrenia.
Drug research.
2018 Jul; 68(7):410-414. doi:
10.1055/s-0044-102093. [PMID: 29482256] - Carmen Belmonte, Dolores Ochoa, Manuel Román, Miriam Saiz-Rodríguez, Aneta Wojnicz, Clara Isabel Gómez-Sánchez, Samuel Martín-Vílchez, Francisco Abad-Santos. Influence of CYP2D6, CYP3A4, CYP3A5 and ABCB1 Polymorphisms on Pharmacokinetics and Safety of Aripiprazole in Healthy Volunteers.
Basic & clinical pharmacology & toxicology.
2018 Jun; 122(6):596-605. doi:
10.1111/bcpt.12960. [PMID: 29325225] - Ian R McGrane, Joshua G Loveland, Jose de Leon. Possible Oxcarbazepine Inductive Effects on Aripiprazole Metabolism: A Case Report.
Journal of pharmacy practice.
2018 Jun; 31(3):361-363. doi:
10.1177/0897190017710523. [PMID: 28539103] - Sanne M Kloosterboer, Brenda C M de Winter, Soma Bahmany, Linda Al-Hassany, Annet Dekker, Gwen C Dieleman, Teun van Gelder, Bram Dierckx, Birgit C P Koch. Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Antipsychotics: Drawbacks of Its Clinical Application.
Therapeutic drug monitoring.
2018 06; 40(3):344-350. doi:
10.1097/ftd.0000000000000502. [PMID: 29505492] - C Rafaniello, M Sessa, F F Bernardi, M Pozzi, S Cheli, D Cattaneo, S Baldelli, M Molteni, R Bernardini, F Rossi, E Clementi, C Bravaccio, S Radice, A Capuano. The predictive value of ABCB1, ABCG2, CYP3A4/5 and CYP2D6 polymorphisms for risperidone and aripiprazole plasma concentrations and the occurrence of adverse drug reactions.
The pharmacogenomics journal.
2018 05; 18(3):422-430. doi:
10.1038/tpj.2017.38. [PMID: 28719598] - Anna Dietrich-Muszalska, Jolanta Kolińska-Łukaszuk. Comparative effects of aripiprazole and selected antipsychotic drugs on lipid peroxidation in plasma.
Psychiatry and clinical neurosciences.
2018 May; 72(5):329-336. doi:
10.1111/pcn.12631. [PMID: 29280533] - Julia Korell, Bruce Green, Allan Rae, Bart Remmerie, An Vermeulen. Determination of plasma concentration reference ranges for oral aripiprazole, olanzapine, and quetiapine.
European journal of clinical pharmacology.
2018 May; 74(5):593-599. doi:
10.1007/s00228-018-2419-3. [PMID: 29392351] - Joseph P Schacht, Konstantin E Voronin, Patrick K Randall, Raymond F Anton. Dopaminergic Genetic Variation Influences Aripiprazole Effects on Alcohol Self-Administration and the Neural Response to Alcohol Cues in a Randomized Trial.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2018 05; 43(6):1247-1256. doi:
10.1038/npp.2017.298. [PMID: 29362512] - Itaru Miura, Yasuto Kunii, Mizuki Hino, Hiroshi Hoshino, Junya Matsumoto, Keiko Kanno-Nozaki, Sho Horikoshi, Haruka Kaneko, Miki Bundo, Kazuya Iwamoto, Hirooki Yabe. DNA methylation of ANKK1 and response to aripiprazole in patients with acute schizophrenia: A preliminary study.
Journal of psychiatric research.
2018 05; 100(?):84-87. doi:
10.1016/j.jpsychires.2018.02.018. [PMID: 29499474] - Yiying Sun, Xiaoyan Lu, Yunyun Gai, Chunjie Sha, Guangyi Leng, Xiucheng Yang, Wanhui Liu. LC-MS/MS method for the determination of the prodrug aripiprazole lauroxil and its three metabolites in plasma and its application to in vitro biotransformation and animal pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Apr; 1081-1082(?):67-75. doi:
10.1016/j.jchromb.2018.02.011. [PMID: 29510329] - Silki, Vivek Ranjan Sinha. Enhancement of In Vivo Efficacy and Oral Bioavailability of Aripiprazole with Solid Lipid Nanoparticles.
AAPS PharmSciTech.
2018 Apr; 19(3):1264-1273. doi:
10.1208/s12249-017-0944-5. [PMID: 29313261] - Seema Zargar, Abdul-Rahman A Al-Majed, Tanveer A Wani. Potentiating and synergistic effect of grapefruit juice on the antioxidant and anti-inflammatory activity of aripiprazole against hydrogen peroxide induced oxidative stress in mice.
BMC complementary and alternative medicine.
2018 Mar; 18(1):106. doi:
10.1186/s12906-018-2169-x. [PMID: 29566693] - Aneta Wojnicz, Carmen Belmonte, Dora Koller, Ana Ruiz-Nuño, Manuel Román, Dolores Ochoa, Francisco Abad-Santos. Effective phospholipids removing microelution-solid phase extraction LC-MS/MS method for simultaneous plasma quantification of aripiprazole and dehydro-aripiprazole: Application to human pharmacokinetic studies.
Journal of pharmaceutical and biomedical analysis.
2018 Mar; 151(?):116-125. doi:
10.1016/j.jpba.2017.12.049. [PMID: 29324280] - Masaru Nakamura, Yasutaka Fujita, Takahiko Nagamine. Serum prolactin levels might become a useful marker for switching strategy to paliperidone palmitate in male schizophrenia patient.
Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists.
2018 03; 10(1):. doi:
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