Forsythoside (BioDeep_00000230511)

 

Secondary id: BioDeep_00000003692, BioDeep_00000402961

PANOMIX_OTCML-2023


代谢物信息卡片


[(2R,3S,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-4,5-dihydroxy-2-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

化学式: C29H36O15 (624.2054106)
中文名称: 连翘脂苷 A, 连翘脂苷A, 连翘酯苷A, 连翘脂苷A
谱图信息: 最多检出来源 Viridiplantae(plant) 80%

分子结构信息

SMILES: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OCCC3=CC(=C(C=C3)O)O)O)O)OC(=O)C=CC4=CC(=C(C=C4)O)O)O)O)O
InChI: InChI=1S/C29H36O15/c1-13-22(35)23(36)25(38)29(42-13)41-12-20-27(44-21(34)7-4-14-2-5-16(30)18(32)10-14)24(37)26(39)28(43-20)40-9-8-15-3-6-17(31)19(33)11-15/h2-7,10-11,13,20,22-33,35-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29+/m0/s1

描述信息

Forsythiaside is a hydroxycinnamic acid.
Forsythiaside is a natural product found in Forsythia suspensa, Veronica stricta, and other organisms with data available.
Forsythiaside A, a phenylethanoside product isolated from air-dried fruits of Forsythia suspense, has anti-inflammatory and antioxidant effects[1].
Forsythiaside A, a phenylethanoside product isolated from air-dried fruits of Forsythia suspense, has anti-inflammatory and antioxidant effects[1].

同义名列表

17 个代谢物同义名

[(2R,3S,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-4,5-dihydroxy-2-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate; (2R,3S,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-4,5-dihydroxy-2-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate; (E)-(2R,3S,4R,5R,6R)-6-(3,4-Dihydroxyphenethoxy)-4,5-dihydroxy-2-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3-yl 3-(3,4-dihydroxyphenyl)acrylate; [(2R,3S,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-4,5-dihydroxy-2-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate; .BETA.-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-, 4-(3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE), (E)-; .BETA.-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-, 4-((2E)-3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE); beta-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-, 4-(3-(3,4-dihydroxyphenyl)-2-propenoate), (E)-; UNII-OUH5BQ893P; Forsythiaside A; Forsythoside-A; forsythoside A; MEGxp0_001187; Forsythiaside; Forsythoside; ACon1_001402; OUH5BQ893P; AC1NQZ1W



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jingjing Liu, Yingkui Gao, Huaqiang Zhang, Zhonghua Hao, Guangwei Zhou, Haojie Wen, Qing Su, Chao Tong, Xu Yang, Xuebing Wang. Forsythiaside A attenuates mastitis via PINK1/Parkin-mediated mitophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 125(?):155358. doi: 10.1016/j.phymed.2024.155358. [PMID: 38241916]
  • Minhui Su, Dinghua Zhou, Jiamin Huang, Ting Yang, Qi Zhou, Yaju Tan. Forsythiaside A exhibits anti-migration and anti-inflammation effects in rheumatoid arthritis in vitro model. International journal of rheumatic diseases. 2024 Jan; 27(1):e14976. doi: 10.1111/1756-185x.14976. [PMID: 37997635]
  • Bo Niu, Minhong Zhao, Xiu'an Gao, Jiangping Xu, Linzhong Yu. TMT-based quantitative proteomics analysis of neuroprotective effects of Forsythoside A on the MPTP-induced Parkinson's disease mouse model. Experimental neurology. 2023 Dec; 373(?):114642. doi: 10.1016/j.expneurol.2023.114642. [PMID: 38056584]
  • Jing Wang, Xinyan Xue, Xingtao Zhao, Lin Luo, Juan Liu, Shu Dai, Fang Zhang, Rui Wu, Yanfang Liu, Cheng Peng, Yunxia Li. Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-γ/RXR-α complex. Journal of advanced research. 2023 Aug; ?(?):. doi: 10.1016/j.jare.2023.08.006. [PMID: 37579917]
  • Ke Fu, Shu Dai, Yanzhi Li, Cheng Ma, Xinyan Xue, Shenglin Zhang, Cheng Wang, Honglin Zhou, Yafang Zhang, Yunxia Li. The protective effect of forsythiaside A on 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestatic liver injury in mice: Based on targeted metabolomics and molecular biology technology. Biochimica et biophysica acta. Molecular basis of disease. 2023 Jul; 1869(8):166822. doi: 10.1016/j.bbadis.2023.166822. [PMID: 37523877]
  • Yi Chen, Wei Wei, Jingnan Fu, Teng Zhang, Jie Zhao, Tao Ma. Forsythiaside A ameliorates sepsis-induced acute kidney injury via anti-inflammation and antiapoptotic effects by regulating endoplasmic reticulum stress. BMC complementary medicine and therapies. 2023 Feb; 23(1):35. doi: 10.1186/s12906-023-03855-7. [PMID: 36737765]
  • Lihong Gong, Honglin Zhou, Shenglin Zhang, Cheng Wang, Ke Fu, Cheng Ma, Yafang Zhang, Cheng Peng, Yunxia Li. CD44-Targeting Drug Delivery System of Exosomes Loading Forsythiaside A Combats Liver Fibrosis via Regulating NLRP3-Mediated Pyroptosis. Advanced healthcare materials. 2023 Jan; ?(?):e2202228. doi: 10.1002/adhm.202202228. [PMID: 36603210]
  • Hurong Pei, Mingxiu Lu, Li Long, Zhangfu Long. Antibacterial mechanism of forsythoside A against Pseudomonas syringae pv. actinidiae. Microbial pathogenesis. 2022 Dec; 173(Pt A):105858. doi: 10.1016/j.micpath.2022.105858. [PMID: 36349569]
  • Qian Guo, Yi Zhang, Zhen-Lin Huang, Bin Lu, Li-Li Ji. [Effect of forsythiaside A against CCl_4-induced liver fibrosis in mice and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Nov; 47(22):6137-6145. doi: 10.19540/j.cnki.cjcmm.20220725.401. [PMID: 36471938]
  • Jing Li, Qiao Qin, Sheng-Hua Zha, Qing-Sheng Zhao, Hang Li, Lu-Peng Liu, Shou-Bu Hou, Bing Zhao. Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a β-Cyclodextrin-Assisted Method. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27207055. [PMID: 36296648]
  • Wang Jun Yuan, Su Ping Zhang, Zhi Yin He, Yan Xia He, She Qi He, Li Jun Liu, Xin Sun, Qin Li. Comparative transcriptome analyses identify genes involved into the biosynthesis of forsythin and forsythoside A in Forsythia suspensa. Functional & integrative genomics. 2022 10; 22(5):731-741. doi: 10.1007/s10142-022-00887-z. [PMID: 35870023]
  • Chunyan Liu, Dong Zhen, Huanhuan Du, Guohua Gong, Yun Wu, Qianqian Ma, Zhe-Shan Quan. Synergistic anti-inflammatory effects of peimine, peiminine, and forsythoside a combination on LPS-induced acute lung injury by inhibition of the IL-17-NF-κB/MAPK pathway activation. Journal of ethnopharmacology. 2022 Sep; 295(?):115343. doi: 10.1016/j.jep.2022.115343. [PMID: 35533916]
  • Jing-Chen Tian, Xuan-Ling Zhang, Jian-Rong Cui, Xin-Gang Li. Impact of Azithromycin on Forsythiaside Pharmacokinetics in Rats: A Population Modeling Method. Current medical science. 2022 Aug; 42(4):863-870. doi: 10.1007/s11596-022-2596-2. [PMID: 35678908]
  • Ke Fu, Cheng Ma, Cheng Wang, Honglin Zhou, Lihong Gong, Yafang Zhang, Yunxia Li. Forsythiaside A alleviated carbon tetrachloride-induced liver fibrosis by modulating gut microbiota composition to increase short-chain fatty acids and restoring bile acids metabolism disorder. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jul; 151(?):113185. doi: 10.1016/j.biopha.2022.113185. [PMID: 35623173]
  • Zhicai Yang, Xiaokang Ning, Ying Zhang. Forsythiaside Protected H9c2 Cardiomyocytes from H2O2-Induced Oxidative Stress and Apoptosis via Activating Nrf2/HO-1 Signaling Pathway. International heart journal. 2022; 63(5):904-914. doi: 10.1536/ihj.21-585. [PMID: 36184550]
  • Chunyue Wang, Shanshan Chen, Hangyu Guo, Hongbo Jiang, Honghan Liu, Haoran Fu, Di Wang. Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation. International journal of biological sciences. 2022; 18(5):2075-2090. doi: 10.7150/ijbs.69714. [PMID: 35342364]
  • Mengting Zhou, Xingtao Zhao, Li Liao, Ying Deng, Meichen Liu, Jing Wang, Xinyan Xue, Yunxia Li. Forsythiaside A Regulates Activation of Hepatic Stellate Cells by Inhibiting NOX4-Dependent ROS. Oxidative medicine and cellular longevity. 2022; 2022(?):9938392. doi: 10.1155/2022/9938392. [PMID: 35035671]
  • Mario Bernardi, Mohammad Reza Ghaani, Omer Bayazeid. Phenylethanoid glycosides as a possible COVID-19 protease inhibitor: a virtual screening approach. Journal of molecular modeling. 2021 Nov; 27(11):341. doi: 10.1007/s00894-021-04963-2. [PMID: 34731296]
  • Lihong Gong, Cheng Wang, Honglin Zhou, Cheng Ma, Yafang Zhang, Cheng Peng, Yunxia Li. A review of pharmacological and pharmacokinetic properties of Forsythiaside A. Pharmacological research. 2021 07; 169(?):105690. doi: 10.1016/j.phrs.2021.105690. [PMID: 34029711]
  • Chen Wei-Ya, Yang Fei-Fei, Li Cui, Li Wen-Hui, Hu Jie, Liao Yong-Hong. Comparison of plasma and pulmonary availability of chlorogenic acid, forsythiaside A and baicalin after intratracheal and intravenous administration of Shuang-Huang-Lian injection. Journal of ethnopharmacology. 2021 Jun; 274(?):114082. doi: 10.1016/j.jep.2021.114082. [PMID: 33813012]
  • Lihong Gong, Honglin Zhou, Cheng Wang, Linfeng He, Chaocheng Guo, Cheng Peng, Yunxia Li. Hepatoprotective effect of forsythiaside a against acetaminophen-induced liver injury in zebrafish: Coupling network pharmacology with biochemical pharmacology. Journal of ethnopharmacology. 2021 May; 271(?):113890. doi: 10.1016/j.jep.2021.113890. [PMID: 33516931]
  • Moritz Zürn, Gergő Tóth, Tim Ausbüttel, Zoltán Mucsi, Kata Horváti, Szilvia Bősze, Magdolna Sütöri-Diószegi, Bernadett Pályi, Zoltán Kis, Béla Noszál, Imre Boldizsár. Tissue-Specific Accumulation and Isomerization of Valuable Phenylethanoid Glycosides from Plantago and Forsythia Plants. International journal of molecular sciences. 2021 Apr; 22(8):. doi: 10.3390/ijms22083880. [PMID: 33918622]
  • Zi-Bin Lu, Shan-Hong Liu, Jin-Ying Ou, Hui-Hui Cao, Ling-Zhu Shi, Dong-Yi Liu, Chun-Yang Tian, Yuan-Ru Zheng, Hong-Ling Zhou, Jun-Shan Liu, Lin-Zhong Yu. Forsythoside A inhibits adhesion and migration of monocytes to type II alveolar epithelial cells in lipopolysaccharide-induced acute lung injury through upregulating miR-124. Toxicology and applied pharmacology. 2020 11; 407(?):115252. doi: 10.1016/j.taap.2020.115252. [PMID: 32987027]
  • Zibin Lu, Huayi Yang, Huihui Cao, Chuying Huo, Yuyao Chen, Dongyi Liu, Pei Xie, Hongling Zhou, Junshan Liu, Linzhong Yu. Forsythoside A protects against lipopolysaccharide-induced acute lung injury through up-regulating microRNA-124. Clinical science (London, England : 1979). 2020 10; 134(19):2549-2563. doi: 10.1042/cs20200598. [PMID: 32975280]
  • Lihong Gong, Linyuan Yu, Xiaohong Gong, Cheng Wang, Naihua Hu, Xuyang Dai, Cheng Peng, Yunxia Li. Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses. Journal of neuroinflammation. 2020 Jun; 17(1):173. doi: 10.1186/s12974-020-01855-9. [PMID: 32493433]
  • Xin-Gang Li, Jian Ni, Su Shen, Xiao-Ping Wang, Jing-Chen Tian. Pharmacokinetic interaction of Forsythia suspensa extract and azithromycin injection after single and co-intravenous administration in rats. Chinese journal of natural medicines. 2020 Mar; 18(3):234-240. doi: 10.1016/s1875-5364(20)30026-1. [PMID: 32245594]
  • Chan Lu, She Feng Zheng, Jinnv Liu. Forsythiaside A alleviates renal damage in adriamycin-induced nephropathy. Frontiers in bioscience (Landmark edition). 2020 01; 25(3):526-535. doi: 10.2741/4818. [PMID: 31585901]
  • Yu Li, Qin Guo, Yan Yan, Tinggui Chen, Chenhui Du, Huizhi Du. Different effects of Forsythia suspensa metabolites on bovine serum albumin (BSA). Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 May; 214(?):309-319. doi: 10.1016/j.saa.2019.02.076. [PMID: 30798212]
  • Liqing Chen, Yan Yan, Tinggui Chen, Liwei Zhang, Xiaoxia Gao, Chenhui Du, Huizhi Du. Forsythiaside prevents β-amyloid-induced hippocampal slice injury by upregulating 2-arachidonoylglycerol via cannabinoid receptor 1-dependent NF-κB pathway. Neurochemistry international. 2019 05; 125(?):57-66. doi: 10.1016/j.neuint.2019.02.008. [PMID: 30769029]
  • Gabriel R Martins, Thamirys Silva da Fonseca, Lucero Martínez-Fructuoso, Rosineide Costa Simas, Fabio T Silva, Fatima Regina G Salimena, Daniela S Alviano, Celuta Sales Alviano, Gilda Guimarães Leitão, Rogelio Pereda-Miranda, Suzana G Leitão. Antifungal Phenylpropanoid Glycosides from Lippia rubella. Journal of natural products. 2019 03; 82(3):566-572. doi: 10.1021/acs.jnatprod.8b00975. [PMID: 30817148]
  • Liqing Chen, Lixia Lin, Zhe Dong, Liwei Zhang, Huizhi Du. Comparison of neuroprotective effect of Forsythia suspensa leaf extract and forsythiaside, one of its metabolites. Natural product research. 2018 Nov; 32(22):2705-2708. doi: 10.1080/14786419.2017.1374266. [PMID: 28882055]
  • Xinsheng Fang, Shubo Gu, Zongyuan Jin, Mingqian Hao, Zhenzhen Yin, Jianhua Wang. Optimization of Ultrasonic-Assisted Simultaneous Extraction of Three Active Compounds from the Fruits of Forsythia suspensa and Comparison with Conventional Extraction Methods. Molecules (Basel, Switzerland). 2018 Aug; 23(9):. doi: 10.3390/molecules23092115. [PMID: 30142873]
  • Fei Wang, Guang-Shang Cao, Yun Li, Lu-Lu Xu, Zhi-Bin Wang, Ying Liu, Jian-Qiu Lu, Jia-Yu Zhang. Characterization of forsythoside A metabolites in rats by a combination of UHPLC-LTQ-Orbitrap mass spectrometer with multiple data processing techniques. Biomedical chromatography : BMC. 2018 May; 32(5):e4164. doi: 10.1002/bmc.4164. [PMID: 29228468]
  • Xiao-Tian Zhang, Yue Ding, Ping Kang, Xin-Yu Zhang, Tong Zhang. Forsythoside A Modulates Zymosan-Induced Peritonitis in Mice. Molecules (Basel, Switzerland). 2018 Mar; 23(3):. doi: 10.3390/molecules23030593. [PMID: 29509714]
  • Anna Hing-Yee Law, Cindy Lai-Hung Yang, Allan Sik-Yin Lau, Godfrey Chi-Fung Chan. Antiviral effect of forsythoside A from Forsythia suspensa (Thunb.) Vahl fruit against influenza A virus through reduction of viral M1 protein. Journal of ethnopharmacology. 2017 Sep; 209(?):236-247. doi: 10.1016/j.jep.2017.07.015. [PMID: 28716571]
  • Jiaolin Bao, Ren-Bo Ding, Yeer Liang, Fang Liu, Kai Wang, Xuejing Jia, Chao Zhang, Meiwan Chen, Peng Li, Huanxing Su, Jian-Bo Wan, Yitao Wang, Chengwei He. Differences in Chemical Component and Anticancer Activity of Green and Ripe Forsythiae Fructus. The American journal of Chinese medicine. 2017; 45(7):1513-1536. doi: 10.1142/s0192415x17500823. [PMID: 28946767]
  • Yu-Tse Wu, Meng-Ting Cai, Chih-Wei Chang, Ching-Chi Yen, Mei-Chich Hsu. Bioanalytical Method Development Using Liquid Chromatography with Amperometric Detection for the Pharmacokinetic Evaluation of Forsythiaside in Rats. Molecules (Basel, Switzerland). 2016 Oct; 21(10):. doi: 10.3390/molecules21101384. [PMID: 27754467]
  • Li Deng, Peng Pang, Ke Zheng, Jiao Nie, Huachong Xu, Sizhi Wu, Jia Chen, Xiaoyin Chen. Forsythoside A Controls Influenza A Virus Infection and Improves the Prognosis by Inhibiting Virus Replication in Mice. Molecules (Basel, Switzerland). 2016 Apr; 21(5):. doi: 10.3390/molecules21050524. [PMID: 27128889]
  • Fan Zhang, Ya-Nan Yang, Xiu-Yun Song, Si-Yuan Shao, Zi-Ming Feng, Jian-Shuang Jiang, Li Li, Nai-Hong Chen, Pei-Cheng Zhang. Forsythoneosides A-D, Neuroprotective Phenethanoid and Flavone Glycoside Heterodimers from the Fruits of Forsythia suspensa. Journal of natural products. 2015 Oct; 78(10):2390-7. doi: 10.1021/acs.jnatprod.5b00372. [PMID: 26422318]
  • Li Cheng, Fan Li, Rui Ma, Xianping Hu. Forsythiaside inhibits cigarette smoke-induced lung inflammation by activation of Nrf2 and inhibition of NF-κB. International immunopharmacology. 2015 Sep; 28(1):494-9. doi: 10.1016/j.intimp.2015.07.011. [PMID: 26209933]
  • Yan Yi, Yu-shi Zhang, Chun-ying Li, Hai-yu Zhao, Hong-bin Xiao, Gui-qin Li, Yu-ting Lu, Jia-yin Han, Yong Zhao, Hong-jie Wang, Nan Si, Ai-hua Liang, Bao-lin Bian. [Study of screening pseudoallergenic substances of Shuanghuanglian injection]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Jul; 40(14):2727-31. doi: . [PMID: 26666017]
  • Jinping Jia, Fusheng Zhang, Zhenyu Li, Xuemei Qin, Liwei Zhang. Comparison of Fruits of Forsythia suspensa at Two Different Maturation Stages by NMR-Based Metabolomics. Molecules (Basel, Switzerland). 2015 May; 20(6):10065-81. doi: 10.3390/molecules200610065. [PMID: 26035103]
  • Chen-Wei Pan, Guang-Yao Zhou, Wei-Lai Chen, Lu Zhuge, Ling-Xiang Jin, Yi Zheng, Wei Lin, Zhen-Zhen Pan. Protective effect of forsythiaside A on lipopolysaccharide/d-galactosamine-induced liver injury. International immunopharmacology. 2015 May; 26(1):80-5. doi: 10.1016/j.intimp.2015.03.009. [PMID: 25797347]
  • ChunKang Huang, Yonglian Lin, Hong Su, Dongqing Ye. Forsythiaside protects against hydrogen peroxide-induced oxidative stress and apoptosis in PC12 cell. Neurochemical research. 2015 Jan; 40(1):27-35. doi: 10.1007/s11064-014-1461-5. [PMID: 25344274]
  • Shihua Xing, Ying Peng, Mengyue Wang, Daofeng Chen, Xiaobo Li. In vitro human fecal microbial metabolism of Forsythoside A and biological activities of its metabolites. Fitoterapia. 2014 Dec; 99(?):159-65. doi: 10.1016/j.fitote.2014.09.018. [PMID: 25281775]
  • Shi-hong Zhong, Rui Gu, Ling-xin Wang, Yan-feng Liao, Xiao-huat Zheng, Xin Zheng, Yun Cao. [Simultaneous determination of seven constituents in Lamiophlomis rotata by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Nov; 39(22):4373-8. doi: . [PMID: 25850270]
  • Wei Zhou, Xiaobin Tan, Jinjun Shan, Ting Liu, Baochang Cai, Liuqing Di. Effect of chito-oligosaccharide on the intestinal absorptions of phenylethanoid glycosides in Fructus Forsythiae extract. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Oct; 21(12):1549-58. doi: 10.1016/j.phymed.2014.06.016. [PMID: 25442264]
  • Lin Zhou, Hui Yang, Yousheng Ai, Yong Xie, Yingjun Fu. [Protective effect of forsythiaside A on acute lung injure induced by lipopolysaccharide in mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2014 Feb; 30(2):151-4. doi: . [PMID: 24491055]
  • Can-Huang Liu, Ta-Si Liu, Chen-Qu Luo, Ji Zhang, Xiao-Yan Zeng, Lei Cui, Li-Juan Xie. [Determination of forsythiaside B and poliumoside in different origin and parts from Callicarpa kwangtungensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Oct; 38(19):3324-6. doi: . [PMID: 24422401]
  • Xinsheng Fang, Yingzi Wang, Jianhua Wang, Jin Zhang, Xin Wang. Microwave-assisted extraction followed by RP-HPLC for the simultaneous extraction and determination of forsythiaside A, rutin, and phillyrin in the fruits of Forsythia suspensa. Journal of separation science. 2013 Aug; 36(16):2672-9. doi: 10.1002/jssc.201300317. [PMID: 23913652]
  • Hong-Mei Wang, Li-Wei Wang, Xin-Min Liu, Chang-Lu Li, Shu-Ping Xu, Ahsana-Dar Farooq. Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice. Pharmacology, biochemistry, and behavior. 2013 Apr; 105(?):134-41. doi: 10.1016/j.pbb.2012.12.016. [PMID: 23290932]
  • Wei Zhou, Haidan Wang, Xuanxuan Zhu, Jinjun Shan, Ailing Yin, Baochang Cai, Liuqing Di. Improvement of intestinal absorption of forsythoside A and chlorogenic acid by different carboxymethyl chitosan and chito-oligosaccharide, application to Flos Lonicerae-Fructus Forsythiae herb couple preparations. PloS one. 2013; 8(5):e63348. doi: 10.1371/journal.pone.0063348. [PMID: 23675483]
  • Wei Zhou, Kun Ming Qin, Jin Jun Shan, Wen Zheng Ju, Shi Jia Liu, Bao Chang Cai, Liu Qing Di. Improvement of intestinal absorption of forsythoside A in weeping forsythia extract by various absorption enhancers based on tight junctions. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Dec; 20(1):47-58. doi: 10.1016/j.phymed.2012.09.014. [PMID: 23089157]
  • Bing He, Shi-Yan Yang, Yan Zhang. [A new method of calibration and positioning in quantitative analysis of multicomponents by single marker]. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Dec; 47(12):1653-9. doi: . [PMID: 23460972]
  • Yun-Xia Li, Ruo-Qi Zhang, Cheng Peng. Assessment and modulation of forsythiaside absorption with MDCKII cells and validation with in situ intestinal experiment. European journal of drug metabolism and pharmacokinetics. 2012 Sep; 37(3):179-86. doi: 10.1007/s13318-012-0088-7. [PMID: 22430364]
  • Wei Zhou, Liu-qing Di, Jin-jun Shan, Xiao-lin Bi, Le-tian Chen, Ling-chong Wang, Bao-chang Cai. In vitro metabolism in Sprague-Dawley rat liver microsomes of forsythoside A in different compositions of Shuang-Huang-Lian. Fitoterapia. 2011 Dec; 82(8):1222-30. doi: 10.1016/j.fitote.2011.08.009. [PMID: 21888954]
  • Jiqing Bai, Xiaoping Wang, Linlin Cao, Ning Zhang, Zhao Zhang. [Effect of habitat processing method on phillyrin and forsythiaside A of Forsythiae Fructus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Dec; 36(23):3258-61. doi: . [PMID: 22393731]
  • Yun-xia Li, Cheng Peng, Liang-hong Ye, Ruo-Qi Zhang, Xue-hua Jiang. Investigation on the absorption of phillyrin and forsythiaside in rat digestive tract. European journal of drug metabolism and pharmacokinetics. 2011 Jun; 36(2):79-85. doi: 10.1007/s13318-011-0031-3. [PMID: 21547451]
  • Wei Zhou, Liu-qing Di, Jin-jun Shan, Xiao-lin Bi, Le-tian Chen, Ling-chong Wang. Intestinal absorption of forsythoside A in different compositions of Shuang-Huang-Lian. Fitoterapia. 2011 Apr; 82(3):375-82. doi: 10.1016/j.fitote.2010.11.012. [PMID: 21075181]
  • Huawei Li, Jufu Wu, Zhongwen Zhang, Yuanyuan Ma, Fangfang Liao, Yu Zhang, Guojuan Wu. Forsythoside a inhibits the avian infectious bronchitis virus in cell culture. Phytotherapy research : PTR. 2011 Mar; 25(3):338-42. doi: 10.1002/ptr.3260. [PMID: 20677175]
  • Hui Jing, Jiao-She Li, Yin-Jing Yang. [Studies on separation and purification of phenylethanoid glycosides from leaves of Forsythia suspensa by macroporous adsorption resin]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2010 Sep; 33(9):1487-90. doi: ". [PMID: 21243782]
  • Jun-Xiao Ye, Wang Wei, Li-Hui Quan, Chun-Yu Liu, Qi Chang, Yong-Hong Liao. An LC-MS/MS method for the simultaneous determination of chlorogenic acid, forsythiaside A and baicalin in rat plasma and its application to pharmacokinetic study of shuang-huang-lian in rats. Journal of pharmaceutical and biomedical analysis. 2010 Aug; 52(4):625-30. doi: 10.1016/j.jpba.2010.01.035. [PMID: 20153596]
  • Yang Cui, Qiao Wang, Xiaowei Shi, Xiaowei Zhang, Xiaona Sheng, Lantong Zhang. Simultaneous quantification of 14 bioactive constituents in Forsythia suspensa by liquid chromatography-electrospray ionisation-mass spectrometry. Phytochemical analysis : PCA. 2010 May; 21(3):253-60. doi: 10.1002/pca.1194. [PMID: 20151400]
  • T Lu, X L Piao, Q Zhang, D Wang, X S Piao, S W Kim. Protective effects of Forsythia suspensa extract against oxidative stress induced by diquat in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Feb; 48(2):764-70. doi: 10.1016/j.fct.2009.12.018. [PMID: 20036301]
  • Geng-Nan Wang, Rui-Le Pan, Yong-Hong Liao, Ying Chen, Jing-Tian Tang, Qi Chang. An LC-MS/MS method for determination of forsythiaside in rat plasma and application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Jan; 878(1):102-6. doi: 10.1016/j.jchromb.2009.11.029. [PMID: 19945919]
  • Yonggang Xia, Bingyou Yang, Qiuhong Wang, Jun Liang, Youhe Wei, Hedan Yu, Qingbo Zhang, Haixue Kuang. Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Forsythia suspensa extract by HPLC coupled with photodiode array detector. Journal of separation science. 2009 Dec; 32(23-24):4113-25. doi: 10.1002/jssc.200900488. [PMID: 19950349]
  • Yaqin Wang, Zhimou Guo, Yu Jin, Xiuli Zhang, Wei Li, Xinmiao Liang. Selective enrichment with 'click oligo (ethylene glycol)' column and TOF-MS characterization of simple phenylpropanoids in the fruits of Forsythia suspensa. Journal of separation science. 2009 Sep; 32(17):2958-66. doi: 10.1002/jssc.200900150. [PMID: 19714658]
  • Xing Wang, Yan Bai, Zhihong Chen, Haiyan Gong, Wei Zhang. [Determination of forsythoside A in fructus forsythiae by NIR]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Aug; 34(16):2071-5. doi: ". [PMID: 19938549]
  • Rong Shi, Zhenyu Xuan, Yueming Ma, Yingying Liu, Hongguo Lu, Tianjiang Sun. Pharmacokinetics of forsythoside after intravenous administration in beagle dogs. European journal of drug metabolism and pharmacokinetics. 2009 Apr; 34(2):101-5. doi: 10.1007/bf03191158. [PMID: 19645219]
  • Yun-Xia Li, Cheng Peng, Ruo-Qi Zhang, Xue Li, Xue-Hua Jiang. Pharmacokinetics of phillyrin and forsythiaside following iv administration to Beagle dog. European journal of drug metabolism and pharmacokinetics. 2009 Apr; 34(2):79-83. doi: 10.1007/bf03191155. [PMID: 19645216]
  • Yun-Xia Li, Xue-Hua Jiang, Hu-Yi Liang, Xue Li. Determination of forsythiaside in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Biomedical chromatography : BMC. 2008 Apr; 22(4):361-6. doi: 10.1002/bmc.940. [PMID: 18059053]
  • Huanhuan Qu, Yongmin Zhang, Yan Wang, Baixue Li, Wenji Sun. Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensa. The Journal of pharmacy and pharmacology. 2008 Feb; 60(2):261-6. doi: 10.1211/jpp.60.2.0016. [PMID: 18237475]
  • Hossein Nazemiyeh, M Mukhlesur Rahman, Simon Gibbons, Lutfun Nahar, Abbas Delazar, Mohammed-Ali Ghahramani, Amir-Hossein Talebpour, Satyajit D Sarker. Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus. Journal of natural medicines. 2008 Jan; 62(1):91-5. doi: 10.1007/s11418-007-0194-z. [PMID: 18404351]
  • Li-Mei Lin, Zhi-Min Wang, Wei-Hao Wang, Chun Li, Ling-Li Cao, Xiao-Guang Zhang. [RP-HPLC analysis of single, merging, and boiled together Lonicera japonica and Forsythia suspense]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Nov; 32(21):2240-3. doi: ". [PMID: 18309663]
  • Yue Shi, Ren-bing Shi. [Relative adscriptions of components in the effective fractions of Yinqiao decoction and its composing individual herbs]. Yao xue xue bao = Acta pharmaceutica Sinica. 2007 Feb; 42(2):192-6. doi: . [PMID: 17518050]
  • Wei-jian Li, Xian-en Li. [Study on quantified relationship between contents of active components in Forsythia suspense and nutrition of soil]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2005 Oct; 30(20):1577-80. doi: ". [PMID: 16422534]
  • Nour-Eddine Es-Safi, Samira Khlifi, Lucien Kerhoas, Albert Kollmann, Ahmed El Abbouyi, Paul-Henri Ducrot. Antioxidant constituents of the aerial parts of Globularia alypum growing in Morocco. Journal of natural products. 2005 Aug; 68(8):1293-6. doi: 10.1021/np0501233. [PMID: 16124783]
  • Sevser Sahpaz, Nancy Garbacki, Monique Tits, Francois Bailleul. Isolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare. Journal of ethnopharmacology. 2002 Mar; 79(3):389-92. doi: 10.1016/s0378-8741(01)00415-9. [PMID: 11849848]
  • I Saracoglu, K Kojima, U S Harput, Y Ogihara. A new phenylethanoid glycoside from Phlomis pungens Willd. var. pungens. Chemical & pharmaceutical bulletin. 1998 Apr; 46(4):726-7. doi: 10.1248/cpb.46.726. [PMID: 9579050]
  • Y Y Cui, S Y Feng, G Zhao, M Z Wang. [HPLC analysis of the active ingredients of Forsythia suspensa]. Yao xue xue bao = Acta pharmaceutica Sinica. 1992; 27(8):603-8. doi: ". [PMID: 1481677]