Forsythoside (BioDeep_00000230511)

 

Secondary id: BioDeep_00000003692, BioDeep_00000402961

PANOMIX_OTCML-2023


代谢物信息卡片


[(2R,3S,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-4,5-dihydroxy-2-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

化学式: C29H36O15 (624.2054)
中文名称: 连翘脂苷 A, 连翘脂苷A, 连翘酯苷A
谱图信息: 最多检出来源 Viridiplantae(plant) 100%

分子结构信息

SMILES: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OCCC3=CC(=C(C=C3)O)O)O)O)OC(=O)C=CC4=CC(=C(C=C4)O)O)O)O)O
InChI: InChI=1S/C29H36O15/c1-13-22(35)23(36)25(38)29(42-13)41-12-20-27(44-21(34)7-4-14-2-5-16(30)18(32)10-14)24(37)26(39)28(43-20)40-9-8-15-3-6-17(31)19(33)11-15/h2-7,10-11,13,20,22-33,35-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29+/m0/s1

描述信息

Forsythiaside is a hydroxycinnamic acid.
Forsythiaside is a natural product found in Forsythia suspensa, Veronica stricta, and other organisms with data available.
Forsythiaside A, a phenylethanoside product isolated from air-dried fruits of Forsythia suspense, has anti-inflammatory and antioxidant effects[1].
Forsythiaside A, a phenylethanoside product isolated from air-dried fruits of Forsythia suspense, has anti-inflammatory and antioxidant effects[1].

同义名列表

18 个代谢物同义名

[(2R,3S,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-4,5-dihydroxy-2-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate; (2R,3S,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-4,5-dihydroxy-2-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate; (E)-(2R,3S,4R,5R,6R)-6-(3,4-Dihydroxyphenethoxy)-4,5-dihydroxy-2-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3-yl 3-(3,4-dihydroxyphenyl)acrylate; [(2R,3S,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-4,5-dihydroxy-2-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate; .BETA.-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-, 4-(3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE), (E)-; .BETA.-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-, 4-((2E)-3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE); beta-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-, 4-(3-(3,4-dihydroxyphenyl)-2-propenoate), (E)-; UNII-OUH5BQ893P; Forsythiaside A; Forsythoside-A; forsythoside A; MEGxp0_001187; Forsythiaside; Forsythoside; ACon1_001402; OUH5BQ893P; AC1NQZ1W; Forsythiaside



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ABCB1, BCL2, CASP3, CASP9, MAPK14, MAPK8, MYD88, NLRP3, PIK3CA, PTGS2, TLR4, TLR7
Peripheral membrane protein 3 ACHE, GORASP1, PTGS2
Endosome membrane 3 MYD88, TLR4, TLR7
Endoplasmic reticulum membrane 4 BCL2, HMOX1, PTGS2, TLR7
Nucleus 10 ACHE, BCL2, CASP3, CASP9, GABPA, HMOX1, MAPK14, MAPK8, MYD88, NLRP3
cytosol 9 BCL2, CASP3, CASP9, HMOX1, MAPK14, MAPK8, MYD88, NLRP3, PIK3CA
nucleoplasm 5 CASP3, GABPA, HMOX1, MAPK14, MAPK8
Cell membrane 4 ABCB1, ACHE, TLR4, TNF
Cytoplasmic side 2 GORASP1, HMOX1
lamellipodium 1 PIK3CA
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 2 GORASP1, NLRP3
Synapse 2 ACHE, MAPK8
cell surface 5 ABCB1, ACHE, MYD88, TLR4, TNF
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 2 ACHE, GORASP1
Golgi membrane 3 GORASP1, NLRP3, TLR7
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 1 NLRP3
Lysosome 1 TLR7
endosome 1 TLR7
plasma membrane 7 ABCB1, ACHE, MYD88, PIK3CA, TLR4, TLR7, TNF
Membrane 7 ABCB1, ACHE, BCL2, HMOX1, NLRP3, TLR4, TLR7
apical plasma membrane 1 ABCB1
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 1 ABCB1
endoplasmic reticulum 5 BCL2, HMOX1, NLRP3, PTGS2, TLR7
extracellular space 6 ACHE, CCL2, HMOX1, IL17A, IL6, TNF
perinuclear region of cytoplasm 4 ACHE, HMOX1, PIK3CA, TLR4
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CASP9, MAPK14, NLRP3
protein-containing complex 4 BCL2, CASP9, MYD88, PTGS2
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 TLR4, TLR7
Secreted 5 ACHE, CCL2, IL17A, IL6, NLRP3
extracellular region 7 ACHE, CCL2, IL17A, IL6, MAPK14, NLRP3, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
Extracellular side 1 ACHE
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 IL17A, TLR4, TNF
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Membrane raft 1 TNF
pore complex 1 BCL2
cis-Golgi network 1 GORASP1
basement membrane 1 ACHE
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 TLR4, TLR7
neuron projection 1 PTGS2
chromatin 1 GABPA
phagocytic cup 2 TLR4, TNF
spindle pole 1 MAPK14
Lipid-anchor, GPI-anchor 1 ACHE
Endomembrane system 2 NLRP3, TLR7
microtubule organizing center 1 NLRP3
side of membrane 1 ACHE
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 IL6, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
synaptic cleft 1 ACHE
external side of apical plasma membrane 1 ABCB1
endolysosome membrane 1 TLR7
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
early phagosome 1 TLR7
Cytoplasmic vesicle, phagosome 1 TLR7
extrinsic component of plasma membrane 1 MYD88
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jingjing Liu, Yingkui Gao, Huaqiang Zhang, Zhonghua Hao, Guangwei Zhou, Haojie Wen, Qing Su, Chao Tong, Xu Yang, Xuebing Wang. Forsythiaside A attenuates mastitis via PINK1/Parkin-mediated mitophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 125(?):155358. doi: 10.1016/j.phymed.2024.155358. [PMID: 38241916]
  • Minhui Su, Dinghua Zhou, Jiamin Huang, Ting Yang, Qi Zhou, Yaju Tan. Forsythiaside A exhibits anti-migration and anti-inflammation effects in rheumatoid arthritis in vitro model. International journal of rheumatic diseases. 2024 Jan; 27(1):e14976. doi: 10.1111/1756-185x.14976. [PMID: 37997635]
  • Bo Niu, Minhong Zhao, Xiu'an Gao, Jiangping Xu, Linzhong Yu. TMT-based quantitative proteomics analysis of neuroprotective effects of Forsythoside A on the MPTP-induced Parkinson's disease mouse model. Experimental neurology. 2023 Dec; 373(?):114642. doi: 10.1016/j.expneurol.2023.114642. [PMID: 38056584]
  • Jing Wang, Xinyan Xue, Xingtao Zhao, Lin Luo, Juan Liu, Shu Dai, Fang Zhang, Rui Wu, Yanfang Liu, Cheng Peng, Yunxia Li. Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-γ/RXR-α complex. Journal of advanced research. 2023 Aug; ?(?):. doi: 10.1016/j.jare.2023.08.006. [PMID: 37579917]
  • Ke Fu, Shu Dai, Yanzhi Li, Cheng Ma, Xinyan Xue, Shenglin Zhang, Cheng Wang, Honglin Zhou, Yafang Zhang, Yunxia Li. The protective effect of forsythiaside A on 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestatic liver injury in mice: Based on targeted metabolomics and molecular biology technology. Biochimica et biophysica acta. Molecular basis of disease. 2023 Jul; 1869(8):166822. doi: 10.1016/j.bbadis.2023.166822. [PMID: 37523877]
  • Yi Chen, Wei Wei, Jingnan Fu, Teng Zhang, Jie Zhao, Tao Ma. Forsythiaside A ameliorates sepsis-induced acute kidney injury via anti-inflammation and antiapoptotic effects by regulating endoplasmic reticulum stress. BMC complementary medicine and therapies. 2023 Feb; 23(1):35. doi: 10.1186/s12906-023-03855-7. [PMID: 36737765]
  • Lihong Gong, Honglin Zhou, Shenglin Zhang, Cheng Wang, Ke Fu, Cheng Ma, Yafang Zhang, Cheng Peng, Yunxia Li. CD44-Targeting Drug Delivery System of Exosomes Loading Forsythiaside A Combats Liver Fibrosis via Regulating NLRP3-Mediated Pyroptosis. Advanced healthcare materials. 2023 Jan; ?(?):e2202228. doi: 10.1002/adhm.202202228. [PMID: 36603210]
  • Hurong Pei, Mingxiu Lu, Li Long, Zhangfu Long. Antibacterial mechanism of forsythoside A against Pseudomonas syringae pv. actinidiae. Microbial pathogenesis. 2022 Dec; 173(Pt A):105858. doi: 10.1016/j.micpath.2022.105858. [PMID: 36349569]
  • Qian Guo, Yi Zhang, Zhen-Lin Huang, Bin Lu, Li-Li Ji. [Effect of forsythiaside A against CCl_4-induced liver fibrosis in mice and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Nov; 47(22):6137-6145. doi: 10.19540/j.cnki.cjcmm.20220725.401. [PMID: 36471938]
  • Jing Li, Qiao Qin, Sheng-Hua Zha, Qing-Sheng Zhao, Hang Li, Lu-Peng Liu, Shou-Bu Hou, Bing Zhao. Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a β-Cyclodextrin-Assisted Method. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27207055. [PMID: 36296648]
  • Wang Jun Yuan, Su Ping Zhang, Zhi Yin He, Yan Xia He, She Qi He, Li Jun Liu, Xin Sun, Qin Li. Comparative transcriptome analyses identify genes involved into the biosynthesis of forsythin and forsythoside A in Forsythia suspensa. Functional & integrative genomics. 2022 10; 22(5):731-741. doi: 10.1007/s10142-022-00887-z. [PMID: 35870023]
  • Chunyan Liu, Dong Zhen, Huanhuan Du, Guohua Gong, Yun Wu, Qianqian Ma, Zhe-Shan Quan. Synergistic anti-inflammatory effects of peimine, peiminine, and forsythoside a combination on LPS-induced acute lung injury by inhibition of the IL-17-NF-κB/MAPK pathway activation. Journal of ethnopharmacology. 2022 Sep; 295(?):115343. doi: 10.1016/j.jep.2022.115343. [PMID: 35533916]
  • Jing-Chen Tian, Xuan-Ling Zhang, Jian-Rong Cui, Xin-Gang Li. Impact of Azithromycin on Forsythiaside Pharmacokinetics in Rats: A Population Modeling Method. Current medical science. 2022 Aug; 42(4):863-870. doi: 10.1007/s11596-022-2596-2. [PMID: 35678908]
  • Ke Fu, Cheng Ma, Cheng Wang, Honglin Zhou, Lihong Gong, Yafang Zhang, Yunxia Li. Forsythiaside A alleviated carbon tetrachloride-induced liver fibrosis by modulating gut microbiota composition to increase short-chain fatty acids and restoring bile acids metabolism disorder. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jul; 151(?):113185. doi: 10.1016/j.biopha.2022.113185. [PMID: 35623173]
  • Zhicai Yang, Xiaokang Ning, Ying Zhang. Forsythiaside Protected H9c2 Cardiomyocytes from H2O2-Induced Oxidative Stress and Apoptosis via Activating Nrf2/HO-1 Signaling Pathway. International heart journal. 2022; 63(5):904-914. doi: 10.1536/ihj.21-585. [PMID: 36184550]
  • Chunyue Wang, Shanshan Chen, Hangyu Guo, Hongbo Jiang, Honghan Liu, Haoran Fu, Di Wang. Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation. International journal of biological sciences. 2022; 18(5):2075-2090. doi: 10.7150/ijbs.69714. [PMID: 35342364]
  • Mengting Zhou, Xingtao Zhao, Li Liao, Ying Deng, Meichen Liu, Jing Wang, Xinyan Xue, Yunxia Li. Forsythiaside A Regulates Activation of Hepatic Stellate Cells by Inhibiting NOX4-Dependent ROS. Oxidative medicine and cellular longevity. 2022; 2022(?):9938392. doi: 10.1155/2022/9938392. [PMID: 35035671]
  • Mario Bernardi, Mohammad Reza Ghaani, Omer Bayazeid. Phenylethanoid glycosides as a possible COVID-19 protease inhibitor: a virtual screening approach. Journal of molecular modeling. 2021 Nov; 27(11):341. doi: 10.1007/s00894-021-04963-2. [PMID: 34731296]
  • Lihong Gong, Cheng Wang, Honglin Zhou, Cheng Ma, Yafang Zhang, Cheng Peng, Yunxia Li. A review of pharmacological and pharmacokinetic properties of Forsythiaside A. Pharmacological research. 2021 07; 169(?):105690. doi: 10.1016/j.phrs.2021.105690. [PMID: 34029711]
  • Chen Wei-Ya, Yang Fei-Fei, Li Cui, Li Wen-Hui, Hu Jie, Liao Yong-Hong. Comparison of plasma and pulmonary availability of chlorogenic acid, forsythiaside A and baicalin after intratracheal and intravenous administration of Shuang-Huang-Lian injection. Journal of ethnopharmacology. 2021 Jun; 274(?):114082. doi: 10.1016/j.jep.2021.114082. [PMID: 33813012]
  • Lihong Gong, Honglin Zhou, Cheng Wang, Linfeng He, Chaocheng Guo, Cheng Peng, Yunxia Li. Hepatoprotective effect of forsythiaside a against acetaminophen-induced liver injury in zebrafish: Coupling network pharmacology with biochemical pharmacology. Journal of ethnopharmacology. 2021 May; 271(?):113890. doi: 10.1016/j.jep.2021.113890. [PMID: 33516931]
  • Moritz Zürn, Gergő Tóth, Tim Ausbüttel, Zoltán Mucsi, Kata Horváti, Szilvia Bősze, Magdolna Sütöri-Diószegi, Bernadett Pályi, Zoltán Kis, Béla Noszál, Imre Boldizsár. Tissue-Specific Accumulation and Isomerization of Valuable Phenylethanoid Glycosides from Plantago and Forsythia Plants. International journal of molecular sciences. 2021 Apr; 22(8):. doi: 10.3390/ijms22083880. [PMID: 33918622]
  • Zi-Bin Lu, Shan-Hong Liu, Jin-Ying Ou, Hui-Hui Cao, Ling-Zhu Shi, Dong-Yi Liu, Chun-Yang Tian, Yuan-Ru Zheng, Hong-Ling Zhou, Jun-Shan Liu, Lin-Zhong Yu. Forsythoside A inhibits adhesion and migration of monocytes to type II alveolar epithelial cells in lipopolysaccharide-induced acute lung injury through upregulating miR-124. Toxicology and applied pharmacology. 2020 11; 407(?):115252. doi: 10.1016/j.taap.2020.115252. [PMID: 32987027]
  • Zibin Lu, Huayi Yang, Huihui Cao, Chuying Huo, Yuyao Chen, Dongyi Liu, Pei Xie, Hongling Zhou, Junshan Liu, Linzhong Yu. Forsythoside A protects against lipopolysaccharide-induced acute lung injury through up-regulating microRNA-124. Clinical science (London, England : 1979). 2020 10; 134(19):2549-2563. doi: 10.1042/cs20200598. [PMID: 32975280]
  • Lihong Gong, Linyuan Yu, Xiaohong Gong, Cheng Wang, Naihua Hu, Xuyang Dai, Cheng Peng, Yunxia Li. Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO4-induced inflammation in zebrafish by metabolomic and proteomic analyses. Journal of neuroinflammation. 2020 Jun; 17(1):173. doi: 10.1186/s12974-020-01855-9. [PMID: 32493433]
  • Xin-Gang Li, Jian Ni, Su Shen, Xiao-Ping Wang, Jing-Chen Tian. Pharmacokinetic interaction of Forsythia suspensa extract and azithromycin injection after single and co-intravenous administration in rats. Chinese journal of natural medicines. 2020 Mar; 18(3):234-240. doi: 10.1016/s1875-5364(20)30026-1. [PMID: 32245594]
  • Chan Lu, She Feng Zheng, Jinnv Liu. Forsythiaside A alleviates renal damage in adriamycin-induced nephropathy. Frontiers in bioscience (Landmark edition). 2020 01; 25(3):526-535. doi: 10.2741/4818. [PMID: 31585901]
  • Yu Li, Qin Guo, Yan Yan, Tinggui Chen, Chenhui Du, Huizhi Du. Different effects of Forsythia suspensa metabolites on bovine serum albumin (BSA). Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 May; 214(?):309-319. doi: 10.1016/j.saa.2019.02.076. [PMID: 30798212]
  • Liqing Chen, Yan Yan, Tinggui Chen, Liwei Zhang, Xiaoxia Gao, Chenhui Du, Huizhi Du. Forsythiaside prevents β-amyloid-induced hippocampal slice injury by upregulating 2-arachidonoylglycerol via cannabinoid receptor 1-dependent NF-κB pathway. Neurochemistry international. 2019 05; 125(?):57-66. doi: 10.1016/j.neuint.2019.02.008. [PMID: 30769029]
  • Gabriel R Martins, Thamirys Silva da Fonseca, Lucero Martínez-Fructuoso, Rosineide Costa Simas, Fabio T Silva, Fatima Regina G Salimena, Daniela S Alviano, Celuta Sales Alviano, Gilda Guimarães Leitão, Rogelio Pereda-Miranda, Suzana G Leitão. Antifungal Phenylpropanoid Glycosides from Lippia rubella. Journal of natural products. 2019 03; 82(3):566-572. doi: 10.1021/acs.jnatprod.8b00975. [PMID: 30817148]
  • Liqing Chen, Lixia Lin, Zhe Dong, Liwei Zhang, Huizhi Du. Comparison of neuroprotective effect of Forsythia suspensa leaf extract and forsythiaside, one of its metabolites. Natural product research. 2018 Nov; 32(22):2705-2708. doi: 10.1080/14786419.2017.1374266. [PMID: 28882055]
  • Xinsheng Fang, Shubo Gu, Zongyuan Jin, Mingqian Hao, Zhenzhen Yin, Jianhua Wang. Optimization of Ultrasonic-Assisted Simultaneous Extraction of Three Active Compounds from the Fruits of Forsythia suspensa and Comparison with Conventional Extraction Methods. Molecules (Basel, Switzerland). 2018 Aug; 23(9):. doi: 10.3390/molecules23092115. [PMID: 30142873]
  • Fei Wang, Guang-Shang Cao, Yun Li, Lu-Lu Xu, Zhi-Bin Wang, Ying Liu, Jian-Qiu Lu, Jia-Yu Zhang. Characterization of forsythoside A metabolites in rats by a combination of UHPLC-LTQ-Orbitrap mass spectrometer with multiple data processing techniques. Biomedical chromatography : BMC. 2018 May; 32(5):e4164. doi: 10.1002/bmc.4164. [PMID: 29228468]
  • Xiao-Tian Zhang, Yue Ding, Ping Kang, Xin-Yu Zhang, Tong Zhang. Forsythoside A Modulates Zymosan-Induced Peritonitis in Mice. Molecules (Basel, Switzerland). 2018 Mar; 23(3):. doi: 10.3390/molecules23030593. [PMID: 29509714]
  • Anna Hing-Yee Law, Cindy Lai-Hung Yang, Allan Sik-Yin Lau, Godfrey Chi-Fung Chan. Antiviral effect of forsythoside A from Forsythia suspensa (Thunb.) Vahl fruit against influenza A virus through reduction of viral M1 protein. Journal of ethnopharmacology. 2017 Sep; 209(?):236-247. doi: 10.1016/j.jep.2017.07.015. [PMID: 28716571]
  • Jiaolin Bao, Ren-Bo Ding, Yeer Liang, Fang Liu, Kai Wang, Xuejing Jia, Chao Zhang, Meiwan Chen, Peng Li, Huanxing Su, Jian-Bo Wan, Yitao Wang, Chengwei He. Differences in Chemical Component and Anticancer Activity of Green and Ripe Forsythiae Fructus. The American journal of Chinese medicine. 2017; 45(7):1513-1536. doi: 10.1142/s0192415x17500823. [PMID: 28946767]
  • Yu-Tse Wu, Meng-Ting Cai, Chih-Wei Chang, Ching-Chi Yen, Mei-Chich Hsu. Bioanalytical Method Development Using Liquid Chromatography with Amperometric Detection for the Pharmacokinetic Evaluation of Forsythiaside in Rats. Molecules (Basel, Switzerland). 2016 Oct; 21(10):. doi: 10.3390/molecules21101384. [PMID: 27754467]
  • Li Deng, Peng Pang, Ke Zheng, Jiao Nie, Huachong Xu, Sizhi Wu, Jia Chen, Xiaoyin Chen. Forsythoside A Controls Influenza A Virus Infection and Improves the Prognosis by Inhibiting Virus Replication in Mice. Molecules (Basel, Switzerland). 2016 Apr; 21(5):. doi: 10.3390/molecules21050524. [PMID: 27128889]
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