Eplerenone (BioDeep_00000002302)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


methyl (1R,2R,2S,9R,10R,11S,15S,17R)-2,15-dimethyl-5,5-dioxo-18-oxaspiro[oxolane-2,14-pentacyclo[8.8.0.0¹,¹⁷.0²,⁷.0¹¹,¹⁵]octadecan]-6-ene-9-carboxylate

化学式: C24H30O6 (414.204228)
中文名称: 依普利酮
谱图信息: 最多检出来源 Homo sapiens(blood) 16.95%

Reviewed

Last reviewed on 2024-07-24.

Cite this Page

Eplerenone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/eplerenone (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000002302). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC
InChI: InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

描述信息

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D000451 - Mineralocorticoid Receptor Antagonists
C - Cardiovascular system > C03 - Diuretics > C03D - Aldosterone antagonists and other potassium-sparing agents > C03DA - Aldosterone antagonists
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics

同义名列表

7 个代谢物同义名

methyl (1R,2R,2S,9R,10R,11S,15S,17R)-2,15-dimethyl-5,5-dioxo-18-oxaspiro[oxolane-2,14-pentacyclo[8.8.0.0¹,¹⁷.0²,⁷.0¹¹,¹⁵]octadecan]-6-ene-9-carboxylate; 9,11-Epoxy-7-(methoxycarbonyl)-3-oxo-17-pregn-4-ene-21,17-carbolactone; Epoxymexrenone; Eplerenone; Eplerenon; LSM-1524; Inspra



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Juan Hao, Panpan Qiang, Lili Fan, Yunzhao Xiong, Yi Chang, Fan Yang, Xiangting Wang, Tatsuo Shimosawa, Shengyu Mu, Qingyou Xu. Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats. Scientific reports. 2024 05; 14(1):9976. doi: 10.1038/s41598-024-60636-z. [PMID: 38693148]
  • Ran Sun, Yali Li, Lei Lv, Weiliang Zhang, Xiaoxia Guo. Efficacy and safety of esaxerenone (CS-3150) in primary hypertension: a meta-analysis. Journal of human hypertension. 2024 Feb; 38(2):102-109. doi: 10.1038/s41371-023-00889-9. [PMID: 38177694]
  • Zhen He, Mengjuan Zhang, Hepeng Xu, Wenping Zhou, Chang Xu, Zheng Wang, Ming He, Xiangting Wang. Yiqi Huoxue Tongluo recipe regulates NR4A1 to improve renal mitochondrial function in unilateral ureteral obstruction (UUO) rats. Pharmaceutical biology. 2022 Dec; 60(1):2308-2318. doi: 10.1080/13880209.2022.2148168. [PMID: 36428248]
  • Thi Minh Phuong Nikrýnová Nguyen, Branislav Štrauch, Ondřej Petrák, Zuzana Krátká, Robert Holaj, Ivana Kurcová, Věra Marešová, Alena Pilková, Jan Hartinger, Petr Waldauf, Tomáš Zelinka, Jiří Widimský. Adherence and blood pressure control in patients with primary aldosteronism. Blood pressure. 2022 12; 31(1):58-63. doi: 10.1080/08037051.2022.2061416. [PMID: 35438025]
  • Fathalla Belal, Mokhtar Mabrouk, Sherin Hammad, Aya Barseem, Hytham Ahmed. Multi-spectroscopic, thermodynamic and molecular docking studies to investigate the interaction of eplerenone with human serum albumin. Luminescence : the journal of biological and chemical luminescence. 2022 Jul; 37(7):1162-1173. doi: 10.1002/bio.4270. [PMID: 35489089]
  • Gege Chen, Yi Chang, Yunzhao Xiong, Juan Hao, Lingjin Liu, Ziqian Liu, Hui Li, Panpan Qiang, Yutong Han, Yunqian Xian, Tatsuo Shimosawa, Xiangting Wang, Fan Yang, Qingyou Xu. Eplerenone inhibits UUO-induced lymphangiogenesis and cardiac fibrosis by attenuating inflammatory injury. International immunopharmacology. 2022 Jul; 108(?):108759. doi: 10.1016/j.intimp.2022.108759. [PMID: 35428023]
  • Toru Iijima, Makoto Katoh, Kei Takedomi, Yasuo Yamamoto, Hidenori Akatsuka, Naritoshi Shirata, Akito Nishi, Misae Takakuwa, Yoshinori Watanabe, Hitomi Munakata, Naomi Koyama, Tomoko Ikeda, Taku Iguchi, Harutoshi Kato, Kohei Kikkawa, Takayuki Kawaguchi. Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist. Journal of medicinal chemistry. 2022 06; 65(12):8127-8143. doi: 10.1021/acs.jmedchem.2c00402. [PMID: 35652647]
  • Toshifumi Nakamura, Benjamin Bonnard, Roberto Palacios-Ramirez, Amaya Fernández-Celis, Frédéric Jaisser, Natalia López-Andrés. Biglycan Is a Novel Mineralocorticoid Receptor Target Involved in Aldosterone/Salt-Induced Glomerular Injury. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126680. [PMID: 35743123]
  • Pieter Martens, João Pedro Ferreira, John Vincent, Paula Abreu, Martijn Busselen, Wilfried Mullens, Wilson W H Tang, Michael Böhm, Bertram Pitt, Faiez Zannad, Patrick Rossignol. Serum sodium and eplerenone use in patients with a myocardial infarction and left ventricular dysfunction or heart failure: insights from the EPHESUS trial. Clinical research in cardiology : official journal of the German Cardiac Society. 2022 Apr; 111(4):380-392. doi: 10.1007/s00392-021-01853-8. [PMID: 33893561]
  • Namrata G Jain, Justin K Chen, Ruchi Mahajan, Jacqueline Kehoe, Pamela Singer, Dilys Whyte, Andrew S Bomback. Use of ofatumumab and eplerenone in post-transplant recurrence of FSGS. Pediatric transplantation. 2022 Mar; 26(2):e14191. doi: 10.1111/petr.14191. [PMID: 34806263]
  • Honglei Hu, Xiaodong Zhao, Xingqian Jin, Shujuan Wang, Wenlong Liang, Xiangguo Cong. Efficacy and safety of eplerenone treatment for patients with diabetic nephropathy: A meta-analysis. PloS one. 2022; 17(3):e0265642. doi: 10.1371/journal.pone.0265642. [PMID: 35324976]
  • Jaejin An, Fang Niu, John J Sim. Cardiovascular and kidney outcomes of spironolactone or eplerenone in combination with ACEI/ARBs in patients with diabetic kidney disease. Pharmacotherapy. 2021 12; 41(12):998-1008. doi: 10.1002/phar.2633. [PMID: 34655484]
  • Eman Abd-Elhakeem, Mohamed El-Nabarawi, Rehab Shamma. Lipid-based nano-formulation platform for eplerenone oral delivery as a potential treatment of chronic central serous chorioretinopathy: in-vitro optimization and ex-vivo assessment. Drug delivery. 2021 Dec; 28(1):642-654. doi: 10.1080/10717544.2021.1902023. [PMID: 33787445]
  • Masayo Koide, Osama F Harraz, Fabrice Dabertrand, Thomas A Longden, Hannah R Ferris, George C Wellman, David C Hill-Eubanks, Adam S Greenstein, Mark T Nelson. Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease. The Journal of clinical investigation. 2021 09; 131(18):. doi: 10.1172/jci149029. [PMID: 34351870]
  • Niels H Brandt-Jacobsen, Per Lav Madsen, Marie Louise Johansen, Jon J Rasmussen, Julie L Forman, Maria R Holm, Niklas Rye Jørgensen, Jens Faber, Patrick Rossignol, Morten Schou, Caroline Kistorp. Mineralocorticoid Receptor Antagonist Improves Cardiac Structure in Type 2 Diabetes: Data From the MIRAD Trial. JACC. Heart failure. 2021 08; 9(8):550-558. doi: 10.1016/j.jchf.2021.02.016. [PMID: 34325885]
  • Stine H Finsen, Mie R Hansen, Joachim Hoffmann-Petersen, Henrik F Højgaard, Stefan P Mortensen. Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes. Physiological reports. 2021 08; 9(15):e14971. doi: 10.14814/phy2.14971. [PMID: 34350730]
  • Niels H Brandt-Jacobsen, Marie Louise Johansen, Jon Rasmussen, Julie L Forman, Maria Refsgaard Holm, Jens Faber, Patrick Rossignol, Morten Schou, Caroline Kistorp. Effect of high-dose mineralocorticoid receptor antagonist eplerenone on urinary albumin excretion in patients with type 2 diabetes and high cardiovascular risk: Data from the MIRAD trial. Diabetes & metabolism. 2021 07; 47(4):101190. doi: 10.1016/j.diabet.2020.08.005. [PMID: 32919068]
  • Jumpei Saito, Asako Mito, Naho Yakuwa, Kayoko Kaneko, Hiroyo Kawasaki, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Atsuko Murashima. Eplerenone levels in maternal serum, cord blood, and breast milk during pregnancy and lactation. Hypertension research : official journal of the Japanese Society of Hypertension. 2021 07; 44(7):879-881. doi: 10.1038/s41440-021-00621-5. [PMID: 33564177]
  • Ezequiel Cordova, Franco Garibaldi, Leandro Bono, Claudia Rodriguez. Severe hyperkalaemia due to a potential drug-drug interaction between eplerenone and antiretrovirals in a HIV-positive patient after a myocardial infarction. International journal of STD & AIDS. 2021 07; 32(8):771-773. doi: 10.1177/0956462420987422. [PMID: 33629924]
  • João Pedro Ferreira, Zohra Lamiral, John J V McMurray, Karl Swedberg, Dirk J van Veldhuisen, John Vincent, Patrick Rossignol, Stuart J Pocock, Bertram Pitt, Faiez Zannad. Impact of Insulin Treatment on the Effect of Eplerenone: Insights From the EMPHASIS-HF Trial. Circulation. Heart failure. 2021 06; 14(6):e008075. doi: 10.1161/circheartfailure.120.008075. [PMID: 34129365]
  • Susan Stienen, João Pedro Ferreira, Christian Bär, Thomas Thum, António Barros, Bertram Pitt, Nicolas Girerd, Patrick Rossignol, Faiez Zannad. Serum microRNAs and antifibrotic response to eplerenone in acute myocardial infarction complicated by systolic dysfunction. International journal of cardiology. 2021 06; 332(?):35-37. doi: 10.1016/j.ijcard.2021.02.088. [PMID: 33676945]
  • Fan Yang, Yi Chang, Cuijuan Zhang, Yunzhao Xiong, Xiangting Wang, Xuelian Ma, Zheng Wang, Hui Li, Tatsuo Shimosawa, Lin Pei, Qingyou Xu. UUO induces lung fibrosis with macrophage-myofibroblast transition in rats. International immunopharmacology. 2021 Apr; 93(?):107396. doi: 10.1016/j.intimp.2021.107396. [PMID: 33540244]
  • Christopher Edwards. New Horizons: Does Mineralocorticoid Receptor Activation by Cortisol Cause ATP Release and COVID-19 Complications?. The Journal of clinical endocrinology and metabolism. 2021 03; 106(3):622-635. doi: 10.1210/clinem/dgaa874. [PMID: 33249452]
  • Takeshi Hasegawa, Hiroki Nishiwaki, Erika Ota, William Mm Levack, Hisashi Noma. Aldosterone antagonists for people with chronic kidney disease requiring dialysis. The Cochrane database of systematic reviews. 2021 02; 2(?):CD013109. doi: 10.1002/14651858.cd013109.pub2. [PMID: 33586138]
  • Ryo Nakamaru, Koichi Yamamoto, Hiroshi Akasaka, Hiromi Rakugi, Isao Kurihara, Takashi Yoneda, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Megumi Fujita, Kenji Oki, Kohei Kamemura, Akiyo Tanabe, Mitsuhide Naruse. Sex Differences in Renal Outcomes After Medical Treatment for Bilateral Primary Aldosteronism. Hypertension (Dallas, Tex. : 1979). 2021 02; 77(2):537-545. doi: 10.1161/hypertensionaha.120.16449. [PMID: 33356395]
  • Akira Kurozumi, Yosuke Okada, Yoshiya Tanaka. Eplerenone Improves Vascular Endothelial Function in Patients with Primary Aldosteronism: A Pilot Study. Journal of UOEH. 2021; 43(4):379-384. doi: 10.7888/juoeh.43.379. [PMID: 34897166]
  • Eman Abdelhakeem, Mohamed El-Nabarawi, Rehab Shamma. Effective Ocular Delivery of Eplerenone Using Nanoengineered Lipid Carriers in Rabbit Model. International journal of nanomedicine. 2021; 16(?):4985-5002. doi: 10.2147/ijn.s319814. [PMID: 34335024]
  • Fathalla Belal, Mokhtar Mabrouk, Sherin Hammad, Aya Barseem, Hytham Ahmed. A Novel Eplerenone Ecofriendly Fluorescent Nanosensor Based on Nitrogen and Sulfur-Carbon Quantum Dots. Journal of fluorescence. 2021 Jan; 31(1):85-90. doi: 10.1007/s10895-020-02638-4. [PMID: 33074428]
  • Viren H Makhijani, Preethi Irukulapati, Kalynn Van Voorhies, Brayden Fortino, Joyce Besheer. Central amygdala mineralocorticoid receptors modulate alcohol self-administration. Neuropharmacology. 2020 12; 181(?):108337. doi: 10.1016/j.neuropharm.2020.108337. [PMID: 33007359]
  • Shinji Kishimoto, Kenji Oki, Tatsuya Maruhashi, Masato Kajikawa, Haruki Hashimoto, Yuji Takaeko, Takahiro Harada, Takayuki Yamaji, Yiming Han, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Farina Mohamad Yusoff, Ayumu Nakashima, Yukihito Higashi. A Comparison of Adrenalectomy and Eplerenone on Vascular Function in Patients with Aldosterone-producing Adenoma. The Journal of clinical endocrinology and metabolism. 2020 11; 105(11):. doi: 10.1210/clinem/dgaa561. [PMID: 32818224]
  • Edmund Ym Chung, Marinella Ruospo, Patrizia Natale, Davide Bolignano, Sankar D Navaneethan, Suetonia C Palmer, Giovanni Fm Strippoli. Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease. The Cochrane database of systematic reviews. 2020 10; 10(?):CD007004. doi: 10.1002/14651858.cd007004.pub4. [PMID: 33107592]
  • Hitoshi Minakuchi, Shu Wakino, Hidenori Urai, Arata Kurokochi, Kazuhiro Hasegawa, Takeshi Kanda, Hirobumi Tokuyama, Hiroshi Itoh. The effect of aldosterone and aldosterone blockade on the progression of chronic kidney disease: a randomized placebo-controlled clinical trial. Scientific reports. 2020 10; 10(1):16626. doi: 10.1038/s41598-020-73638-4. [PMID: 33024237]
  • Atsushi Hashimoto, Yoshimichi Takeda, Shigehiro Karashima, Mitsuhiro Kometani, Daisuke Aono, Masashi Demura, Takuya Higashitani, Seigo Konishi, Takashi Yoneda, Yoshiyu Takeda. Impact of mineralocorticoid receptor blockade with direct renin inhibition in angiotensin II-dependent hypertensive mice. Hypertension research : official journal of the Japanese Society of Hypertension. 2020 10; 43(10):1099-1104. doi: 10.1038/s41440-020-0458-5. [PMID: 32398797]
  • Danli Hu, Ruolan Dong, Yanjun Zhang, Yan Yang, Zhihui Chen, Ying Tang, Menglu Fu, Xizhen Xu, Ling Tu. Age‑related changes in mineralocorticoid receptors in rat hearts. Molecular medicine reports. 2020 09; 22(3):1859-1867. doi: 10.3892/mmr.2020.11260. [PMID: 32582979]
  • Xue Wang, Yuhai Zhu, Shuanglin Wang, Zhuoqun Wang, Haonan Sun, Yujie He, Wei Yao. Effects of eplerenone on cerebral aldosterone levels and brain lesions in spontaneously hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993). 2020 Aug; 42(6):531-538. doi: 10.1080/10641963.2020.1723615. [PMID: 32020810]
  • Adhish Agarwal, Alfred K Cheung. Mineralocorticoid Receptor Antagonists in ESKD. Clinical journal of the American Society of Nephrology : CJASN. 2020 07; 15(7):1047-1049. doi: 10.2215/cjn.13221019. [PMID: 32269029]
  • Amanda E Garza, Elijah Trefts, Isis A Katayama Rangel, Danielle Brooks, Rene Baudrand, Burhanuddin Moize, Jose R Romero, Sanjay Ranjit, Thitinan Treesaranuwattana, Tham M Yao, Gail K Adler, Luminita H Pojoga, Gordon H Williams. Striatin heterozygous mice are more sensitive to aldosterone-induced injury. The Journal of endocrinology. 2020 06; 245(3):439-450. doi: 10.1530/joe-19-0562. [PMID: 32229698]
  • Milla Marques Hermidorff, Leonardo Vinícius Monteiro de Assis, Joel Alves Rodrigues, Leôncio Lopes Soares, Milton Hércules Guerra Andrade, Antônio José Natali, Mauro Cesar Isoldi. Mineralocorticoid receptor antagonists lead to increased adenosine bioavailability and modulate contractile cardiac parameters. Heart and vessels. 2020 May; 35(5):719-730. doi: 10.1007/s00380-019-01542-7. [PMID: 31820090]
  • Thitinan Treesaranuwattana, Kelly Yin Han Wong, Danielle L Brooks, Chee Sin Tay, Gordon H Williams, Jonathan S Williams, Luminita H Pojoga. Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor. Hypertension (Dallas, Tex. : 1979). 2020 04; 75(4):1045-1053. doi: 10.1161/hypertensionaha.119.13821. [PMID: 32160100]
  • Keisuke Okamura, Masatoshi Matsushima, Fumi Yamamoto, Yosuke Takamiya, Tetsu Okuda, Kazuyuki Shirai, Katsusuke Okamura, Hidenori Urata. A Patient with Bilateral Primary Aldosteronism Refractory to Oral Eplerenone Who Responded to Esaxerenone with Increased Renin Activity. The American journal of case reports. 2020 Jan; 21(?):e920615. doi: 10.12659/ajcr.920615. [PMID: 31907345]
  • Andrea Vecchiola, Cristóbal A Fuentes, Isidora Solar, Carlos F Lagos, Maria Cecilia Opazo, Natalia Muñoz-Durango, Claudia A Riedel, Gareth I Owen, Alexis M Kalergis, Carlos E Fardella. Eplerenone Implantation Improved Adipose Dysfunction Averting RAAS Activation and Cell Division. Frontiers in endocrinology. 2020; 11(?):223. doi: 10.3389/fendo.2020.00223. [PMID: 32373073]
  • Mostafa El Mokadem, Yasser Abd El Hady, Ashraf Aziz. A Prospective Single-Blind Randomized Trial of Ramipril, Eplerenone and Their Combination in Type 2 Diabetic Nephropathy. Cardiorenal medicine. 2020; 10(6):392-401. doi: 10.1159/000508670. [PMID: 32998143]
  • Kawa Dizaye, Zana A Mustafa. The effect of eplerenone on the renin-angiotensin-aldosterone system of rats with thyroid dysfunction. The Journal of pharmacy and pharmacology. 2019 Dec; 71(12):1800-1808. doi: 10.1111/jphp.13168. [PMID: 31579950]
  • Maolin Yu, Mark W Ledeboer, Matthew Daniels, Goran Malojcic, Thomas T Tibbitts, Marie Coeffet-Le Gal, Xin-Ru Pan-Zhou, Amy Westerling-Bui, Maria Beconi, John F Reilly, Peter Mundel, Jean-Christophe Harmange. Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model. ACS medicinal chemistry letters. 2019 Nov; 10(11):1579-1585. doi: 10.1021/acsmedchemlett.9b00430. [PMID: 31749913]
  • Marie L Johansen, Morten Schou, Patrick Rossignol, Maria R Holm, Jon Rasmussen, Niels Brandt, Mikkel Frandsen, Elizaveta Chabanova, Flemming Dela, Jens Faber, Caroline Kistorp. Effect of the mineralocorticoid receptor antagonist eplerenone on liver fat and metabolism in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial (MIRAD trial). Diabetes, obesity & metabolism. 2019 10; 21(10):2305-2314. doi: 10.1111/dom.13809. [PMID: 31183945]
  • Elodie Bousquet, Min Zhao, Alejandra Daruich, Francine Behar-Cohen. Mineralocorticoid antagonists in the treatment of central serous chorioetinopathy: Review of the pre-clinical and clinical evidence. Experimental eye research. 2019 10; 187(?):107754. doi: 10.1016/j.exer.2019.107754. [PMID: 31401003]
  • Keiko Hosohata, Denan Jin, Shinji Takai, Kazunori Iwanaga. Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats. International journal of molecular sciences. 2019 Sep; 20(18):. doi: 10.3390/ijms20184481. [PMID: 31514290]
  • Qi-Qiang Jie, Gang Li, Jiang-Bo Duan, Xue-Bin Li, Wei Yang, Yan-Peng Chu, Shan-Dong Yu, Xiao-Yan Liu, Cheng-Yu Wang, Fei-Fei Liu, Feng Ze, Yu-Wen Huang, Ying Chen, Yan-Sheng Ding, Ji-Hong Guo, Lin Wu. Remodeling of myocardial energy and metabolic homeostasis in a sheep model of persistent atrial fibrillation. Biochemical and biophysical research communications. 2019 09; 517(1):8-14. doi: 10.1016/j.bbrc.2019.05.112. [PMID: 31307785]
  • Yusuke Nakazawa, Shinya Inoue, Yuka Nakamura, Yasuo Iida, Yasuhito Ishigaki, Katsuhito Miyazawa. High-salt diet promotes crystal deposition through hypertension in Dahl salt-sensitive rat model. International journal of urology : official journal of the Japanese Urological Association. 2019 08; 26(8):839-846. doi: 10.1111/iju.14035. [PMID: 31257672]
  • Alessandra Ocello, Sandra La Rosa, Fulvio Fiorini, Salvatore Randone, Rosario Maccarrone, Giorgio Battaglia, Antonio Granata. [Antifibrotic renal role of mineralcorticoid receptor antagonists]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. 2019 Jul; 36(4):. doi: . [PMID: 31373464]
  • Danielle L Brooks, Amanda E Garza, Isis A Katayama, Jose R Romero, Gail K Adler, Luminita H Pojoga, Gordon H Williams. Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice. Endocrinology. 2019 04; 160(4):716-728. doi: 10.1210/en.2018-00989. [PMID: 30726893]
  • Mitsuhiro Nishimoto, Hiroshi Ohtsu, Takeshi Marumo, Wakako Kawarazaki, Nobuhiro Ayuzawa, Kohei Ueda, Daigoro Hirohama, Fumiko Kawakami-Mori, Shigeru Shibata, Miki Nagase, Masashi Isshiki, Shigeyoshi Oba, Tatsuo Shimosawa, Toshiro Fujita. Mineralocorticoid receptor blockade suppresses dietary salt-induced ACEI/ARB-resistant albuminuria in non-diabetic hypertension: a sub-analysis of evaluate study. Hypertension research : official journal of the Japanese Society of Hypertension. 2019 04; 42(4):514-521. doi: 10.1038/s41440-018-0201-7. [PMID: 30631161]
  • João Pedro Ferreira, Paula Abreu, John J V McMurray, Dirk J van Veldhuisen, Karl Swedberg, Stuart J Pocock, John Vincent, Katharina Lins, Patrick Rossignol, Bertram Pitt, Faiez Zannad. Renal function stratified dose comparisons of eplerenone versus placebo in the EMPHASIS-HF trial. European journal of heart failure. 2019 03; 21(3):345-351. doi: 10.1002/ejhf.1400. [PMID: 30768732]
  • Kenneth L Granberg, Zhong-Qing Yuan, Bo Lindmark, Karl Edman, Johan Kajanus, Anders Hogner, Marcus Malmgren, Gavin O'Mahony, Anneli Nordqvist, Jan Lindberg, Stefan Tångefjord, Michael Kossenjans, Christian Löfberg, Jonas Brånalt, Dongmei Liu, Nidhal Selmi, Grigorios Nikitidis, Peter Nordberg, Ahlke Hayen, Anna Aagaard, Eva Hansson, Majlis Hermansson, Ida Ivarsson, Rasmus Jansson-Löfmark, Ulla Karlsson, Ulrika Johansson, Lena William-Olsson, Judith Hartleib-Geschwindner, Krister Bamberg. Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection. Journal of medicinal chemistry. 2019 02; 62(3):1385-1406. doi: 10.1021/acs.jmedchem.8b01523. [PMID: 30596500]
  • Christopher R Heier, Qing Yu, Alyson A Fiorillo, Christopher B Tully, Asya Tucker, Davi A Mazala, Kitipong Uaesoontrachoon, Sadish Srinivassane, Jesse M Damsker, Eric P Hoffman, Kanneboyina Nagaraju, Christopher F Spurney. Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy. Life science alliance. 2019 02; 2(1):. doi: 10.26508/lsa.201800186. [PMID: 30745312]
  • Masayoshi Yamamoto, Yoshihiro Seo, Tomoko Ishizu, Isao Nishi, Yoshie Hamada-Harimura, Tomoko Machino-Ohtsuka, Haruhiko Higuchi, Seika Sai, Tomofumi Nakatsukasa, Akinori Sugano, Masako Baba, Kenichi Obara, Kazutaka Aonuma. Comparison of effects of aldosterone receptor antagonists spironolactone and eplerenone on cardiovascular outcomes and safety in patients with acute decompensated heart failure. Heart and vessels. 2019 Feb; 34(2):279-289. doi: 10.1007/s00380-018-1250-1. [PMID: 30203391]
  • Tsutomu Wada, Hiroshi Tsuneki, Toshiyasu Sasaoka. [Role of Angiogenesis and Chronic Inflammation in Fat Hypertrophy in NASH Pathology]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2019; 139(9):1163-1167. doi: 10.1248/yakushi.19-00011-3. [PMID: 31474632]
  • Krister Bamberg, Lena William-Olsson, Ulrika Johansson, Rasmus Jansson-Löfmark, Judith Hartleib-Geschwindner. The selective mineralocorticoid receptor modulator AZD9977 reveals differences in mineralocorticoid effects of aldosterone and fludrocortisone. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2019 Jan; 20(1):1470320319827449. doi: 10.1177/1470320319827449. [PMID: 30813831]
  • Kanika Aggarwal, Aniruddha Agarwal, Vishali Gupta. An unusual case of multifocal central serous chorioretinopathy with low serum cortisol managed using eplerenone. Indian journal of ophthalmology. 2019 Jan; 67(1):167-170. doi: 10.4103/ijo.ijo_651_18. [PMID: 30574936]
  • Xuelian Ma, Yi Chang, Yunzhao Xiong, Zheng Wang, Xiangting Wang, Qingyou Xu. Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction. Nephron. 2019; 142(3):233-242. doi: 10.1159/000497489. [PMID: 30799394]
  • Sandor Koszegi, Agnes Molnar, Lilla Lenart, Judit Hodrea, Dora Bianka Balogh, Tamas Lakat, Edgar Szkibinszkij, Adam Hosszu, Nadja Sparding, Federica Genovese, Laszlo Wagner, Adam Vannay, Attila J Szabo, Andrea Fekete. RAAS inhibitors directly reduce diabetes-induced renal fibrosis via growth factor inhibition. The Journal of physiology. 2019 01; 597(1):193-209. doi: 10.1113/jp277002. [PMID: 30324679]
  • Jennifer E Hundt, Stephanie Sass, Wolfgang Funk, Tamás Bíró, Nicolette Farman, Ewan A Langan, Ralf Paus. Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo. Skin pharmacology and physiology. 2019; 32(6):344-348. doi: 10.1159/000501729. [PMID: 31522177]
  • Sophie Girerd, Luc Frimat, Didier Ducloux, Yannick Le Meur, Christophe Mariat, Bruno Moulin, Christiane Mousson, Philippe Rieu, Nassim Dali-Youcef, Ludovic Merckle, Xavier Lepage, Patrick Rossignol, Nicolas Girerd, Frédéric Jaisser. EPURE Transplant (Eplerenone in Patients Undergoing Renal Transplant) study: study protocol for a randomized controlled trial. Trials. 2018 Oct; 19(1):595. doi: 10.1186/s13063-018-2956-1. [PMID: 30376884]
  • Sandra Korol, Michel White, Eileen O'Meara, François Tournoux, Normand Racine, Anique Ducharme, Jean-Lucien Rouleau, Mark Liszkowski, Asmaa Mansour, Martin Jutras, Marie-Claude Guertin, Mathieu Bernier, Joël Lavoie, Grégoire Leclair, Paul-Eduard Neagoe, Diana Chaar, Martin G Sirois, Simon de Denus. A comparison of the effects of selective and non-selective mineralocorticoid antagonism on glucose homeostasis of heart failure patients with glucose intolerance or type II diabetes: A randomized controlled double-blind trial. American heart journal. 2018 10; 204(?):190-195. doi: 10.1016/j.ahj.2018.07.002. [PMID: 30097164]
  • Yujiro Nakano, Takanobu Yoshimoto, Tatsuya Fukuda, Masanori Murakami, Ryotaro Bouchi, Isao Minami, Koshi Hashimoto, Yasuhisa Fujii, Kazunori Kihara, Yoshihiro Ogawa. Effect of Eplerenone on the Glomerular Filtration Rate (GFR) in Primary Aldosteronism: Sequential Changes in the GFR During Preoperative Eplerenone Treatment to Subsequent Adrenalectomy. Internal medicine (Tokyo, Japan). 2018 Sep; 57(17):2459-2466. doi: 10.2169/internalmedicine.0438-17. [PMID: 29709927]
  • Benjamin Bonnard, Marie Pieronne-Deperrois, Zoubir Djerada, Soumaya Elmoghrabi, Peter Kolkhof, Antoine Ouvrard-Pascaud, Paul Mulder, Frédéric Jaisser, Smail Messaoudi. Mineralocorticoid receptor antagonism improves diastolic dysfunction in chronic kidney disease in mice. Journal of molecular and cellular cardiology. 2018 08; 121(?):124-133. doi: 10.1016/j.yjmcc.2018.06.008. [PMID: 29981797]
  • Ida Löfman, Karolina Szummer, Henrik Olsson, Juan-Jesus Carrero, Lars H Lund, Tomas Jernberg. Association Between Mineralocorticoid Receptor Antagonist Use and Outcome in Myocardial Infarction Patients With Heart Failure. Journal of the American Heart Association. 2018 07; 7(14):. doi: 10.1161/jaha.118.009359. [PMID: 29980521]
  • Fredrik Erlandsson, Muna Albayaty, Ligia Chialda, Hans Ericsson, Carl Amilon, Karin Nelander, Rasmus Jansson-Löfmark, Linda Wernevik, Magnus Kjaer, Krister Bamberg, Judith Hartleib-Geschwindner. Clinical safety, tolerability, pharmacokinetics and effects on urinary electrolyte excretion of AZD9977, a novel, selective mineralocorticoid receptor modulator. British journal of clinical pharmacology. 2018 07; 84(7):1486-1493. doi: 10.1111/bcp.13562. [PMID: 29468715]
  • Suman Srinivasa, Kathleen V Fitch, Kimberly Wong, Timothy K O'Malley, Patrick Maehler, Karen L Branch, Sara E Looby, Tricia H Burdo, Edgar L Martinez-Salazar, Martin Torriani, Shannon H Lyons, Julian Weiss, Meghan Feldpausch, Takara L Stanley, Gail K Adler, Steven K Grinspoon. Randomized, Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Metabolic and Inflammatory Indices in HIV. The Journal of clinical endocrinology and metabolism. 2018 06; 103(6):2376-2384. doi: 10.1210/jc.2018-00330. [PMID: 29659888]
  • Stefan Pilz, Christian Trummer, Nicolas Verheyen, Verena Schwetz, Marlene Pandis, Felix Aberer, Martin R Grübler, Andreas Meinitzer, Antonia Bachmann, Jakob Voelkl, Ioana Alesutan, Cristiana Catena, Leonardo A Sechi, Winfried März, Barbara Obermayer-Pietsch, Andreas Tomaschitz. Mineralocorticoid Receptor Blockers and Aldosterone to Renin Ratio: A Randomized Controlled Trial and Observational Data. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2018 May; 50(5):375-382. doi: 10.1055/a-0604-3249. [PMID: 29723896]
  • Jia-Jia Zhu, Yi-Pu Chen, Min Yang, Bao-Li Liu, Jing Dong, Hong-Rui Dong, Hong-Liang Rui, Hong Cheng. Aldosterone is involved in the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes. Molecular medicine reports. 2018 03; 17(3):4589-4598. doi: 10.3892/mmr.2018.8386. [PMID: 29328453]
  • Roger Hullin, Mélanie Métrich, Alexandre Sarre, Denis Basquin, Marc Maillard, Julien Regamey, David Martin. Diverging effects of enalapril or eplerenone in primary prevention against doxorubicin-induced cardiotoxicity. Cardiovascular research. 2018 02; 114(2):272-281. doi: 10.1093/cvr/cvx162. [PMID: 29016737]
  • João Pedro Ferreira, Kévin Duarte, Gilles Montalescot, Bertram Pitt, Esteban Lopez de Sa, Christian W Hamm, Marcus Flather, Freek Verheugt, Harry Shi, Eva Turgonyi, Miguel Orri, Patrick Rossignol, John Vincent, Faiez Zannad. Effect of eplerenone on extracellular cardiac matrix biomarkers in patients with acute ST-elevation myocardial infarction without heart failure: insights from the randomized double-blind REMINDER Study. Clinical research in cardiology : official journal of the German Cardiac Society. 2018 Jan; 107(1):49-59. doi: 10.1007/s00392-017-1157-3. [PMID: 28852839]
  • Krister Bamberg, Ulrika Johansson, Karl Edman, Lena William-Olsson, Susanna Myhre, Anders Gunnarsson, Stefan Geschwindner, Anna Aagaard, Anna Björnson Granqvist, Frédéric Jaisser, Yufeng Huang, Kenneth L Granberg, Rasmus Jansson-Löfmark, Judith Hartleib-Geschwindner. Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion. PloS one. 2018; 13(2):e0193380. doi: 10.1371/journal.pone.0193380. [PMID: 29474466]
  • Jason M Elinoff, Li-Yuan Chen, Edward J Dougherty, Keytam S Awad, Shuibang Wang, Angelique Biancotto, Afsheen H Siddiqui, Nargues A Weir, Rongman Cai, Junfeng Sun, Ioana R Preston, Michael A Solomon, Robert L Danner. Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-κB and AP-1 signalling. Cardiovascular research. 2018 01; 114(1):65-76. doi: 10.1093/cvr/cvx198. [PMID: 29036418]
  • Hiroyuki Tsutsui, Hiroshi Ito, Masafumi Kitakaze, Issei Komuro, Toyoaki Murohara, Tohru Izumi, Kenji Sunagawa, Yoshio Yasumura, Masafumi Yano, Kazuhiro Yamamoto, Tsutomu Yoshikawa, Takayoshi Tsutamoto, Junwei Zhang, Akifumi Okayama, Yoshihiko Ichikawa, Kazuhiro Kanmuri, Masunori Matsuzaki. Double-Blind, Randomized, Placebo-Controlled Trial Evaluating the Efficacy and Safety of Eplerenone in Japanese Patients With Chronic Heart Failure (J-EMPHASIS-HF). Circulation journal : official journal of the Japanese Circulation Society. 2017 12; 82(1):148-158. doi: 10.1253/circj.cj-17-0323. [PMID: 28824029]
  • Nicolas Verheyen, Martin R Grübler, Andreas Meinitzer, Christian Trummer, Verena Schwetz, Karin Amrein, Hans P Dimai, Winfried März, Cristiana Catena, Dirk von Lewinski, Jakob Voelkl, Ioana Alesutan, Astrid Fahrleitner-Pammer, Helmut Brussee, Stefan Pilz, Andreas Tomaschitz. Effect of eplerenone on markers of bone turnover in patients with primary hyperparathyroidism - The randomized, placebo-controlled EPATH trial. Bone. 2017 Dec; 105(?):212-217. doi: 10.1016/j.bone.2017.08.030. [PMID: 28918310]
  • Toshiki Sawai, Kaoru Dohi, Naoki Fujimoto, Setsuya Okubo, Naoki Isaka, Takehiko Ichikawa, Katsutoshi Makino, Shinya Okamoto, Sukenari Koyabu, Tetsuya Kitamura, Toru Ogura, Tomomi Yamada, Satoshi Tamaru, Masakatsu Nishikawa, Mashio Nakamura, Masaaki Ito. Antialbuminuric effect of eplerenone in comparison to thiazide diuretics in patients with hypertension. Journal of clinical hypertension (Greenwich, Conn.). 2017 Oct; 19(10):990-998. doi: 10.1111/jch.13054. [PMID: 28849629]
  • Masato Kawasaki, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Yoshio Furukawa, Shunsuke Tamaki, Yusuke Iwasaki, Atsushi Kikuchi, Yasushi Sakata, Masatake Fukunami. Eplerenone might affect atrial fibrosis in patients with hypertension. Pacing and clinical electrophysiology : PACE. 2017 Oct; 40(10):1096-1102. doi: 10.1111/pace.13169. [PMID: 28845908]
  • Farheen K Dojki, George Bakris. Nonsteroidal mineralocorticoid antagonists in diabetic kidney disease. Current opinion in nephrology and hypertension. 2017 09; 26(5):368-374. doi: 10.1097/mnh.0000000000000340. [PMID: 28771453]
  • A Olivier, N Girerd, J B Michel, J M Ketelslegers, R Fay, J Vincent, P Bramlage, B Pitt, F Zannad, P Rossignol. Combined baseline and one-month changes in big endothelin-1 and brain natriuretic peptide plasma concentrations predict clinical outcomes in patients with left ventricular dysfunction after acute myocardial infarction: Insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) study. International journal of cardiology. 2017 Aug; 241(?):344-350. doi: 10.1016/j.ijcard.2017.02.018. [PMID: 28284500]
  • Clarice K Fujihara, M C Kowala, M D Breyer, Claudia R Sena, Mariliza V Rodrigues, Simone C A Arias, Camilla Fanelli, Denise M Malheiros, P K Jadhav, Chahrzad Montrose-Rafizadeh, Jose E Krieger, Roberto Zatz. A Novel Aldosterone Antagonist Limits Renal Injury in 5/6 Nephrectomy. Scientific reports. 2017 08; 7(1):7899. doi: 10.1038/s41598-017-08383-2. [PMID: 28801620]
  • Mara Medeiros, Luis Velásquez-Jones, Ana M Hernández, Guillermo Ramón-García, Saúl Valverde, Yolanda Fuentes, Arindal Vargas, Mauricio Patiño, Rosalba Pérez-Villalva, Juan Antonio Ortega-Trejo, Jonatan Barrera-Chimal, Norma A Bobadilla. Randomized Controlled Trial of Mineralocorticoid Receptor Blockade in Children with Chronic Kidney Allograft Nephropathy. Clinical journal of the American Society of Nephrology : CJASN. 2017 Aug; 12(8):1291-1300. doi: 10.2215/cjn.05300516. [PMID: 28536123]
  • Tatjana Kalizki, Bernhard M W Schmidt, Ulrike Raff, Annemarie Reinold, Thomas K Schwarz, Markus P Schneider, Roland E Schmieder, Andreas Schneider. Low dose-eplerenone treatment decreases aortic stiffness in patients with resistant hypertension. Journal of clinical hypertension (Greenwich, Conn.). 2017 Jul; 19(7):669-676. doi: 10.1111/jch.12986. [PMID: 28211216]
  • Patrick Rossignol, Nicolas Girerd, George Bakris, Orly Vardeny, Brian Claggett, John J V McMurray, Karl Swedberg, Henry Krum, Dirk J van Veldhuisen, Harry Shi, Sean Spanyers, John Vincent, Renaud Fay, Zohra Lamiral, Scott D Solomon, Faiez Zannad, Bertram Pitt. Impact of eplerenone on cardiovascular outcomes in heart failure patients with hypokalaemia. European journal of heart failure. 2017 06; 19(6):792-799. doi: 10.1002/ejhf.688. [PMID: 27868385]
  • Fayaz Ali Larik, Aamer Saeed, Danish Shahzad, Muhammad Faisal, Hesham El-Seedi, Haroon Mehfooz, Pervaiz Ali Channar. Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives. Steroids. 2017 02; 118(?):76-92. doi: 10.1016/j.steroids.2016.12.010. [PMID: 28041953]
  • Viljami Jokinen, Tuomas Lilius, Jouko Laitila, Mikko Niemi, Oleg Kambur, Eija Kalso, Pekka Rauhala. Do Diuretics have Antinociceptive Actions: Studies of Spironolactone, Eplerenone, Furosemide and Chlorothiazide, Individually and with Oxycodone and Morphine. Basic & clinical pharmacology & toxicology. 2017 Jan; 120(1):38-45. doi: 10.1111/bcpt.12634. [PMID: 27312359]
  • Cong-Hui Wang, Zheng Wang, Li-Juan Liang, Xiang-Ting Wang, Xue-Lian Ma, Bei-Bei Liu, Jia-Qi He, Tatsuo Shimosawa, Qing-You Xu. The Inhibitory Effect of Eplerenone on Cell Proliferation in the Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction. Nephron. 2017; 136(4):328-338. doi: 10.1159/000473702. [PMID: 28402979]
  • Peter Kolkhof, Frederic Jaisser, So-Young Kim, Gerasimos Filippatos, Christina Nowack, Bertram Pitt. Steroidal and Novel Non-steroidal Mineralocorticoid Receptor Antagonists in Heart Failure and Cardiorenal Diseases: Comparison at Bench and Bedside. Handbook of experimental pharmacology. 2017; 243(?):271-305. doi: 10.1007/164_2016_76. [PMID: 27830348]
  • Panagiotis I Georgianos, Vasilios Vaios, Theodoros Eleftheriadis, Pantelis Zebekakis, Vassilios Liakopoulos. Mineralocorticoid Antagonists in ESRD: An Overview of Clinical Trial Evidence. Current vascular pharmacology. 2017; 15(6):599-606. doi: 10.2174/1570161115666170201113817. [PMID: 28155610]
  • Katarzyna Bus-Kwasnik, Monika Filist, Piotr J Rudzki. ENVIRONMENTALLY FRIENDLY LC/MS DETERMINATION OF EPLERENONE IN HUMAN PLASMA. Acta poloniae pharmaceutica. 2016 Nov; 73(6):1487-1493. doi: . [PMID: 29634102]
  • Yutaka Kakizoe, Yoshikazu Miyasato, Tomoaki Onoue, Terumasa Nakagawa, Manabu Hayata, Kohei Uchimura, Jun Morinaga, Teruhiko Mizumoto, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Kimio Tomita, Masashi Mukoyama, Kenichiro Kitamura. A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity. Journal of pharmacological sciences. 2016 Oct; 132(2):145-153. doi: 10.1016/j.jphs.2016.09.005. [PMID: 27773435]
  • Kevin Quach, Lyubov Lvtvyn, Colin Baigent, Joe Bueti, Amit X Garg, Carmel Hawley, Richard Haynes, Braden Manns, Vlado Perkovic, Christian G Rabbat, Ron Wald, Michael Walsh. The Safety and Efficacy of Mineralocorticoid Receptor Antagonists in Patients Who Require Dialysis: A Systematic Review and Meta-analysis. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2016 Oct; 68(4):591-598. doi: 10.1053/j.ajkd.2016.04.011. [PMID: 27265777]
  • Anja Hofmann, Coy Brunssen, Mirko Peitzsch, Melanie Martin, Jennifer Mittag, Anett Jannasch, Felix Engelmann, Nicholas F Brown, Steven M Weldon, Jochen Huber, Rüdiger Streicher, Andreas Deussen, Graeme Eisenhofer, Stefan R Bornstein, Henning Morawietz. Aldosterone Synthase Inhibition Improves Glucose Tolerance in Zucker Diabetic Fatty (ZDF) Rats. Endocrinology. 2016 Oct; 157(10):3844-3855. doi: 10.1210/en.2016-1358. [PMID: 27526033]
  • Rene Baudrand, Nidhi Gupta, Amanda E Garza, Anand Vaidya, Jane A Leopold, Paul N Hopkins, Xavier Jeunemaitre, Claudio Ferri, Jose R Romero, Jonathan Williams, Joseph Loscalzo, Gail K Adler, Gordon H Williams, Luminita H Pojoga. Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis. Journal of the American Heart Association. 2016 09; 5(10):. doi: 10.1161/jaha.116.003845. [PMID: 27680666]
  • William C Valinsky, Anna Jolly, Perrine Miquel, Rhian M Touyz, Alvin Shrier. Aldosterone Upregulates Transient Receptor Potential Melastatin 7 (TRPM7). The Journal of biological chemistry. 2016 09; 291(38):20163-72. doi: 10.1074/jbc.m116.735175. [PMID: 27466368]
  • U D Lichtenauer, S Gerum, E Asbach, J Manolopoulou, V Fourkiotis, M Quinkler, M Bidlingmaier, M Reincke. The Clinical Value of Salivary Aldosterone in Diagnosis and Follow-Up of Primary Aldosteronism. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2016 Sep; 48(10):638-643. doi: 10.1055/s-0042-114037. [PMID: 27589343]
  • Gerasimos Filippatos, Stefan D Anker, Michael Böhm, Mihai Gheorghiade, Lars Køber, Henry Krum, Aldo P Maggioni, Piotr Ponikowski, Adriaan A Voors, Faiez Zannad, So-Young Kim, Christina Nowack, Giovanni Palombo, Peter Kolkhof, Nina Kimmeskamp-Kirschbaum, Alexander Pieper, Bertram Pitt. A randomized controlled study of finerenone vs. eplerenone in patients with worsening chronic heart failure and diabetes mellitus and/or chronic kidney disease. European heart journal. 2016 Jul; 37(27):2105-14. doi: 10.1093/eurheartj/ehw132. [PMID: 27130705]
  • Andreas Tomaschitz, Nicolas Verheyen, Andreas Meinitzer, Burkert Pieske, Evgeny Belyavskiy, Helmut Brussee, Josef Haas, Winfried März, Elisabeth Pieske-Kraigher, Sarah Verheyen, Lisa Ofner-Ziegenfuss, Bríain Ó Hartaigh, Verena Schwetz, Felix Aberer, Martin Grübler, Florian Lang, Ioana Alesutan, Jakob Voelkl, Martin Gaksch, Jörg H Horina, Hans-Peter Dimai, Jutta Rus-Machan, Claudia Stiegler, Eberhard Ritz, Astrid Fahrleitner-Pammer, Stefan Pilz. Effect of eplerenone on parathyroid hormone levels in patients with primary hyperparathyroidism: results from the EPATH randomized, placebo-controlled trial. Journal of hypertension. 2016 07; 34(7):1347-56. doi: 10.1097/hjh.0000000000000927. [PMID: 27065001]