Lysine (BioDeep_00000229613)
Main id: BioDeep_00000001375
human metabolite PANOMIX_OTCML-2023
代谢物信息卡片
L-Lysine
化学式: C6H14N2O2 (146.1055224)
中文名称: L-赖氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CCN)CC(C(=O)O)N
InChI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)
描述信息
B - Blood and blood forming organs > B05 - Blood substitutes and perfusion solutions > B05X - I.v. solution additives > B05XB - Amino acids
L-lysine is an essential amino acid[1][2] with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions[2].
L-lysine is an essential amino acid[1][2] with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions[2].
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:18019
- KEGG: C00047
- PubChem: 5962
- HMDB: HMDB00182
- DrugBank: DB00123
- ChEMBL: CHEMBL8085
- MeSH: Lysine
- CAS: 12798-06-0
- CAS: 25104-18-1
- CAS: 20166-34-1
- CAS: 56-87-1
- MoNA: MT000133
- PubChem: 3349
- KNApSAcK: C00001378
- PDB-CCD: LYS
- 3DMET: B00013
- NIKKAJI: J9.176F
- RefMet: Lysine
- medchemexpress: HY-N0469
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bin Zhu, Jinjie Yang, Jingjing Dou, Yijie Ning, Baokun Qi, Yang Li. Comparison of the physical stability, microstructure and protein-lipid co-oxidation of O/W emulsions stabilized by l-arginine/l-lysine-modified soy protein hydrolysate.
Food chemistry.
2024 Jul; 447(?):138901. doi:
10.1016/j.foodchem.2024.138901. [PMID: 38458131] - Qing Liu, Zepeng Zhang, Peng Ji, Jiaqi Liu, Boxue Chen, Mingyao E, Hongyu Qi, Tong Hou, Qingxia Huang, Lu Ding, Chen Guo, Daqing Zhao, Wenzhi Yang, Zeyu Wang, Xiangyan Li. Ginseng polysaccharide components attenuate obesity and liver lipid accumulation by regulating fecal microbiota and hepatic lysine degradation.
International journal of biological macromolecules.
2024 Jun; 269(Pt 1):131872. doi:
10.1016/j.ijbiomac.2024.131872. [PMID: 38677706] - Jun Lu, Weinan Wang, Chunguo Fan, Jingjing Sun, Guozhen Yuan, Yuhan Guo, Xinyu Yu, Yufei Chang, Jinyi Liu, Changquan Wang. Telo boxes within the AGAMOUS second intron recruit histone 3 lysine 27 methylation to increase petal number in rose (Rosa chinensis) in response to low temperatures.
The Plant journal : for cell and molecular biology.
2024 Jun; 118(5):1486-1499. doi:
10.1111/tpj.16691. [PMID: 38457289] - Bei-Bei Hu, Wen-Ting Yin, Heng-Bo Zhang, Zhuo-Qing Zhai, Hua-Min Liu, Xue-de Wang. The interaction between lipid oxidation and the Maillard reaction model of lysine-glucose on aroma formation in fragrant sesame oil.
Food research international (Ottawa, Ont.).
2024 Jun; 186(?):114397. doi:
10.1016/j.foodres.2024.114397. [PMID: 38729739] - Daniela Quiroz, Satoyo Oya, Diego Lopez-Mateos, Kehan Zhao, Alice Pierce, Lissandro Ortega, Alissza Ali, Pablo Carbonell-Bejerano, Vladimir Yarov-Yarovoy, Sae Suzuki, Gosuke Hayashi, Akihisa Osakabe, Grey Monroe. H3K4me1 recruits DNA repair proteins in plants.
The Plant cell.
2024 May; 36(6):2410-2426. doi:
10.1093/plcell/koae089. [PMID: 38531669] - Jie Zhang, Yuanyuan Yu, Xiuqun Zou, Yaning Du, Qiankun Liang, Mengyao Gong, Yurong He, Junqi Luo, Dandan Wu, Xiaoli Jiang, Matt Sinclair, Emad Tajkhorshid, Hong-Zhuan Chen, Zhaoyuan Hou, Yuejuan Zheng, Lin-Feng Chen, Xiao-Dong Yang. WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.
Nucleic acids research.
2024 May; 52(9):4969-4984. doi:
10.1093/nar/gkae161. [PMID: 38452206] - Liman Zhang, Huibin Wang, Chaoling Xue, Yin Liu, Yao Zhang, Zhiguo Liu, Xiangrui Meng, Mengjun Liu, Jin Zhao. The crotonylated and succinylated proteins of jujube involved in phytoplasma-stress responses.
BMC biology.
2024 May; 22(1):113. doi:
10.1186/s12915-024-01917-x. [PMID: 38750524] - Zhiyong Ren, Xiang Dong, Lun Guan, Lei Yang, Caiyun Liu, Xuan Cai, Hong Hu, Ziwei Lv, Hao Liu, Lu Zheng, Junbin Huang, Richard A Wilson, Xiao-Lin Chen. Sirt5-mediated lysine desuccinylation regulates oxidative stress adaptation in Magnaporthe oryzae during host intracellular infection.
The New phytologist.
2024 May; 242(3):1257-1274. doi:
10.1111/nph.19683. [PMID: 38481385] - Sihem Fodil, Marta De Zotti, Silvio Tundo, Laura Gabbatore, Irene Vettorazzo, Simone Luti, Rita Musetti, Luca Sella, Francesco Favaron, Ivan Baccelli. Multiple lysine substitutions in the peptaibol trichogin GA IV enhance the antibiotic activity against plant pathogenic Pseudomonas syringae.
Pesticide biochemistry and physiology.
2024 May; 201(?):105901. doi:
10.1016/j.pestbp.2024.105901. [PMID: 38685232] - Mostafa Yousefian, Saeid Abedimanesh, Amirhossein Yadegar, Manouchehr Nakhjavani, S Zahra Bathaie. Co-administration of 'L-Lysine, Vitamin C, and Zinc' increased the antioxidant activity, decreased insulin resistance, and improved lipid profile in streptozotocin-induced diabetic rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 May; 174(?):116525. doi:
10.1016/j.biopha.2024.116525. [PMID: 38599057] - Yongqiang Ding, Yangxuan Liu, Kexin Yang, Yiran Zhao, Chun Wen, Yi Yang, Wei Zhang. Proteomic Analysis of Lysine Acetylation and Succinylation to Investigate the Pathogenicity of Virulent Pseudomonas syringae pv. tomato DC3000 and Avirulent Line Pseudomonas syringae pv. tomato DC3000 avrRpm1 on Arabidopsis thaliana.
Genes.
2024 Apr; 15(4):. doi:
10.3390/genes15040499. [PMID: 38674433] - Zigang Shen, Zhuojun Ke, Qiong Yang, Samson Teweldeberhan Ghebremichael, Tangxin Li, Tian Li, Jie Chen, Xianzhi Meng, Heng Xiang, Chunfeng Li, Zeyang Zhou, Guoqing Pan, Ping Chen. Transcriptomic changes in the microsporidia proliferation and host responses in congenitally infected embryos and larvae.
BMC genomics.
2024 Apr; 25(1):321. doi:
10.1186/s12864-024-10236-y. [PMID: 38556880] - Yanan Chen, Zhonghao Jiang, Zhuo Yan, Jierong Liu, Yilin Lai, Li Li, Xiao Lin, Jiantao Lin. A codelivery system loaded with PDL1-siRNA and sorafenib enhances the therapeutic effect of sorafenib on hepatocellular carcinoma via TAT-poly-SS-lysine modified chitosan.
International journal of biological macromolecules.
2024 Apr; 263(Pt 1):130162. doi:
10.1016/j.ijbiomac.2024.130162. [PMID: 38365149] - Qinhui Lu, Zhidong Xu, Zhuo Chen, Guangle Qiu. Effects of foliar application of Zn combined with organic matters on Cd accumulation and its chemical forms in rice.
Environmental science and pollution research international.
2024 Apr; 31(17):25182-25191. doi:
10.1007/s11356-024-32808-x. [PMID: 38466386] - J Preston Hurst, Shirley Sato, Tyler Ferris, Abou Yobi, You Zhou, Ruthie Angelovici, Tom E Clemente, David R Holding. Editing the 19 kDa alpha-zein gene family generates non-opaque2-based quality protein maize.
Plant biotechnology journal.
2024 Apr; 22(4):946-959. doi:
10.1111/pbi.14237. [PMID: 37988568] - Youssef A Attia, Ahmed A Abdallah, Fulvia Bovera, Abd El-Hamid E Abd El-Hamid, Asmaa Sh El-Naggar, Rashed A Alhotan, Vincenzo Tufarelli, Reda M Zaki. Effect of dietary electrolyte balance and arginine to lysine ratio on hematological, antioxidant and immunological traits in dual-purpose breeding hens under cyclic heat stress condition.
Journal of thermal biology.
2024 Apr; 121(?):103835. doi:
10.1016/j.jtherbio.2024.103835. [PMID: 38531186] - Subhasis Mandal, Suman Mallik, Avinandan Bhoumick, Anindita Bhattacharya, Prosenjit Sen. Synthesis of Amino Acid-Based Cationic Lipids and Study of the Role of the Cationic Head Group for Enhanced Drug and Nucleic Acid Delivery.
Chembiochem : a European journal of chemical biology.
2024 03; 25(6):e202300834. doi:
10.1002/cbic.202300834. [PMID: 38284327] - Pei Xiong, Wen-Wen Wang, Xu-Sheng Liu, Yu-Feng Wang, Jia-Lin Wang. A CTL - Lys immune function maintains insect metamorphosis by preventing gut bacterial dysbiosis and limiting opportunistic infections.
BMC biology.
2024 Mar; 22(1):54. doi:
10.1186/s12915-024-01855-8. [PMID: 38448930] - Yue Yu, Feng Zhao, Yaping Yue, Yu Zhao, Dao-Xiu Zhou. Lysine acetylation of histone acetyltransferase adaptor protein ADA2 is a mechanism of metabolic control of chromatin modification in plants.
Nature plants.
2024 03; 10(3):439-452. doi:
10.1038/s41477-024-01623-0. [PMID: 38326652] - Kristen A Johnson, Melissa R Budicini, Nisha Bhattarai, Tej Sharma, Sarah Urata, Bernard S Gerstman, Prem P Chapagain, Sheng Li, Robert V Stahelin. PI(4,5)P2 binding sites in the Ebola virus matrix protein VP40 modulate assembly and budding.
Journal of lipid research.
2024 03; 65(3):100512. doi:
10.1016/j.jlr.2024.100512. [PMID: 38295986] - Shujin Wang, Yinying Han, Ruimin Liu, Mengqian Hou, Dietbert Neumann, Jun Zhang, Fang Wang, Yumeng Li, Xueya Zhao, Francesco Schianchi, Chao Dai, Lizhong Liu, Miranda Nabben, Jan F C Glatz, Xin Wu, Xifeng Lu, Xi Li, Joost J F P Luiken. Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis.
Circulation research.
2024 03; 134(5):505-525. doi:
10.1161/circresaha.123.322910. [PMID: 38422177] - Yen-Hua Huang, Zhihao Jiang, Qingdan Du, Kuok Yap, Aurélien Bigot, Quentin Kaas, Conan K Wang, David J Craik. Scanning mutagenesis identifies residues that improve the long-term stability and insecticidal activity of cyclotide kalata B1.
The Journal of biological chemistry.
2024 Mar; 300(3):105682. doi:
10.1016/j.jbc.2024.105682. [PMID: 38272233] - Vasudevan Ayyappan, Venkateswara R Sripathi, Shaojun Xie, Malay C Saha, Rita Hayford, Desalegn D Serba, Mayavan Subramani, Jyothi Thimmapuram, Antonette Todd, Venu Kal Kalavacharla. Genome-wide profiling of histone (H3) lysine 4 (K4) tri-methylation (me3) under drought, heat, and combined stresses in switchgrass.
BMC genomics.
2024 Feb; 25(1):223. doi:
10.1186/s12864-024-10068-w. [PMID: 38424499] - Brijesh K Mehta, Hema S Chauhan, Sudipta Basu, Anjali Anand, Aanchal Baveja, Rajkumar U Zunjare, Vignesh Muthusamy, Ashok K Singh, Firoz Hossain. Mutant crtRB1 gene negates the unfavourable effects of opaque2 gene on germination and seed vigour among shrunken2-based biofortified sweet corn genotypes.
Functional plant biology : FPB.
2024 02; 51(?):. doi:
10.1071/fp23179. [PMID: 38326234] - Josephine Labus, Kerstin Tang, Petra Henklein, Ulrike Krüger, Andreas Hofmann, Sylvia Hondke, Kerstin Wöltje, Christian Freund, Lothar Lucka, Kerstin Danker. The α1 integrin cytoplasmic tail interacts with phosphoinositides and interferes with Akt activation.
Biochimica et biophysica acta. Biomembranes.
2024 Feb; 1866(2):184257. doi:
10.1016/j.bbamem.2023.184257. [PMID: 37992949] - Narigul Khamzaeva, Christina Kunz, Alexandra Schamann, Larissa Pferdmenges, Karlis Briviba. Bioaccessibility and Digestibility of Proteins in Plant-Based Drinks and Cow's Milk: Antioxidant Potential of the Bioaccessible Fraction.
Journal of agricultural and food chemistry.
2024 Jan; 72(4):2300-2308. doi:
10.1021/acs.jafc.3c07221. [PMID: 38235666] - Kun Jia, Mingkun Yang, Xin Liu, Qi Zhang, Gaoxiang Cao, Feng Ge, Jindong Zhao. Deciphering the structure, function, and mechanism of lysine acetyltransferase cGNAT2 in cyanobacteria.
Plant physiology.
2024 Jan; 194(2):634-661. doi:
10.1093/plphys/kiad509. [PMID: 37770070] - Amy K Bracken, Colby E Gekko, Nina O Suss, Emma E Lueders, Qi Cui, Qin Fu, Andy C W Lui, Elizabeth T Anderson, Sheng Zhang, Mikail E Abbasov. Biomimetic Synthesis and Chemical Proteomics Reveal the Mechanism of Action and Functional Targets of Phloroglucinol Meroterpenoids.
Journal of the American Chemical Society.
2024 Jan; 146(4):2524-2548. doi:
10.1021/jacs.3c10741. [PMID: 38230968] - Shahin Ramazi, Seyed Amir Hossein Tabatabaei, Elham Khalili, Amirhossein Golshan Nia, Kiomars Motarjem. Analysis and review of techniques and tools based on machine learning and deep learning for prediction of lysine malonylation sites in protein sequences.
Database : the journal of biological databases and curation.
2024 Jan; 2024(?):. doi:
10.1093/database/baad094. [PMID: 38245002] - Hassan Barakat, Maryam M Al-Qabba, Raya Algonaiman, Khadija S Radhi, Abdulkarim S Almutairi, Muath M Al Zhrani, Ahmed Mohamed. Impact of Sprouting Process on the Protein Quality of Yellow and Red Quinoa (Chenopodium quinoa).
Molecules (Basel, Switzerland).
2024 Jan; 29(2):. doi:
10.3390/molecules29020404. [PMID: 38257317] - Anna Szuba-Trznadel, Anna Jama-Rodzeńska, Bernard Gałka, Rafał Ramut, Zygmunt Król, Daniel Jarki, Dragana Latković. The impact of the distribution method for struvite (Crystal Green) on the chemical composition of soybean and their utility in animal nutrition.
Scientific reports.
2024 01; 14(1):1093. doi:
10.1038/s41598-024-51625-3. [PMID: 38212440] - Xinhang Li, Yulin Zhu, Zihui Yao, Ruiguang Ge. The lysine 2-hydroxyisobutyrylome of Helicobacter pylori: Indicating potential roles of lysine 2-hydroxyisobutyrylation in the bacterial metabolism.
Microbial pathogenesis.
2024 Jan; 186(?):106510. doi:
10.1016/j.micpath.2023.106510. [PMID: 38147967] - Kailin Jiao, Keke Yang, Jie Wang, Yifan Ni, Chunyan Hu, Jiao Liu, Ming Zhou, Jin Zheng, Zhong Li. 27-Hydroxycholesterol induces liver fibrosis via down-regulation of trimethylation of histone H3 at lysine 27 by activating oxidative stress; effect of nutrient interventions.
Free radical biology & medicine.
2024 Jan; 210(?):462-477. doi:
10.1016/j.freeradbiomed.2023.11.043. [PMID: 38056577] - Yonat Tzur, Katarzyna Winek, Nimrod Madrer, Serafima Dubnov, Estelle R Bennett, David S Greenberg, Geula Hanin, Asaad Gammal, Joseph Tam, Isaiah T Arkin, Iddo Paldor, Hermona Soreq. Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2.
Molecular metabolism.
2024 Jan; 79(?):101856. doi:
10.1016/j.molmet.2023.101856. [PMID: 38141848] - Pui Kit Suen, Lizhen Zheng, Qing-Qing Yang, Wan Sheung Mak, Wan Yu Pak, Kit Ying Mo, Man-Ling Chan, Qiao-Quan Liu, Ling Qin, Samuel Sai-Ming Sun. Lysine-rich rice partially enhanced the growth and development of skeletal system with better skeletal microarchitecture in young rats.
Nutrition research (New York, N.Y.).
2024 Jan; 121(?):67-81. doi:
10.1016/j.nutres.2023.11.005. [PMID: 38043437] - Mehmet Emin Aydemir, Ali Arslan, Kasım Takım, Serap Kılıç Altun, Mustafa Abdullah Yılmaz, Oğuz Çakır. Inhibitory effect of Paliurus spina-christi Mill., Celtis tournefortii L. and Nigella sativa L. on Nε-(Carboxymethyl) lysine in meatballs.
Meat science.
2024 Jan; 207(?):109362. doi:
10.1016/j.meatsci.2023.109362. [PMID: 37871485] - Razia Liaqat, Shafaq Fatima, Wajeeha Komal, Qandeel Minahal, Aya S Hussain. Dietary supplementation of methionine, lysine, and tryptophan as possible modulators of growth, immune response, and disease resistance in striped catfish (Pangasius hypophthalmus).
PloS one.
2024; 19(4):e0301205. doi:
10.1371/journal.pone.0301205. [PMID: 38625974] - Ying Bao, Qian Pan, Ping Xu, Zhiheng Liu, Zhixuan Zhang, Yongshuo Liu, Yiyuan Xu, Ying Yu, Zhuo Zhou, Wensheng Wei. Unbiased interrogation of functional lysine residues in human proteome.
Molecular cell.
2023 Dec; 83(24):4614-4632.e6. doi:
10.1016/j.molcel.2023.10.033. [PMID: 37995688] - Samira Saeidi Akbarzadeh, Elaheh Pourfakhraei, Mohsen Zargar, Mona Kashanchi, Seyed Soheil Aghaei. Introducing of high rich lysine, arginine, and unsaturated fatty acids microalga as a food supplement.
World journal of microbiology & biotechnology.
2023 Dec; 40(2):43. doi:
10.1007/s11274-023-03839-2. [PMID: 38105384] - Mohammad K Okla, Muhammad Hamzah Saleem, Ibrahim A Saleh, Naser Zomot, Shagufta Perveen, Abida Parveen, Fozia Abasi, Habib Ali, Baber Ali, Yasmeen A Alwasel, Mostafa A Abdel-Maksoud, Mükerrem Atalay Oral, Sadia Javed, Sezai Ercisli, Muhammad Hassan Sarfraz, Mahdy H Hamed. Foliar application of iron-lysine to boost growth attributes, photosynthetic pigments and biochemical defense system in canola (Brassica napus L.) under cadmium stress.
BMC plant biology.
2023 Dec; 23(1):648. doi:
10.1186/s12870-023-04672-3. [PMID: 38102555] - Min Zhang, Jing-Jing Fu, Jun-Long Mao, Xiu-Ping Dong, Yue-Wen Chen. Lipidomics reveals the relationship between lipid oxidation and flavor formation of basic amnio acids participated Low-Sodium cured large yellow croaker.
Food chemistry.
2023 Dec; 429(?):136888. doi:
10.1016/j.foodchem.2023.136888. [PMID: 37463537] - Yaoguang Hua, Shuli Liu, Sai-Sai Xie, Linjing Shi, Juncheng Li, Qunfeng Luo. Heterobifunctional Cross-Linker with Dinitroimidazole and N-Hydroxysuccinimide Ester Motifs for Protein Functionalization and Cysteine-Lysine Peptide Stapling.
Organic letters.
2023 Dec; 25(49):8792-8796. doi:
10.1021/acs.orglett.3c03250. [PMID: 38059767] - Joseph Oddy, Monika Chhetry, Rajani Awal, John Addy, Mark Wilkinson, Dan Smith, Robert King, Chris Hall, Rebecca Testa, Eve Murray, Sarah Raffan, Tanya Y Curtis, Luzie Wingen, Simon Griffiths, Simon Berry, J Stephen Elmore, Nicholas Cryer, Isabel Moreira de Almeida, Nigel G Halford. Genetic control of grain amino acid composition in a UK soft wheat mapping population.
The plant genome.
2023 Dec; 16(4):e20335. doi:
10.1002/tpg2.20335. [PMID: 37138544] - Shusei Mori, Satoyo Oya, Mayumi Takahashi, Kazuya Takashima, Soichi Inagaki, Tetsuji Kakutani. Cotranscriptional demethylation induces global loss of H3K4me2 from active genes in Arabidopsis.
The EMBO journal.
2023 Dec; 42(23):e113798. doi:
10.15252/embj.2023113798. [PMID: 37849386] - Na Li, Xuan Wu, Hailong Liu, Diandong Xie, Shuqi Hao, Zeyu Lu, Wei Quan, Jie Chen, Huaide Xu, Mei Li. Effect of edible oil type on the formation of protein-bound Nε-(carboxymethyl)lysine in roasted pork patties.
Food research international (Ottawa, Ont.).
2023 Dec; 174(Pt 1):113628. doi:
10.1016/j.foodres.2023.113628. [PMID: 37986479] - Daria N Melnikova, Ivan V Bogdanov, Andrey E Potapov, Anna S Alekseeva, Ekaterina I Finkina, Tatiana V Ovchinnikova. Molecular Insight into Ligand Binding and Transport by the Lentil Lipid Transfer Protein Lc-LTP2: The Role of Basic Amino Acid Residues at Opposite Entrances to the Hydrophobic Cavity.
Biomolecules.
2023 11; 13(12):. doi:
10.3390/biom13121699. [PMID: 38136572] - Junke Zhu, Weiwei Guo, Yubin Lan. Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat.
International journal of molecular sciences.
2023 Nov; 24(22):. doi:
10.3390/ijms242216195. [PMID: 38003390] - Linna Du, Han Yang, Yufei Ren, Yanli Ding, Yichao Xu, Xiaolin Zi, Hongmin Liu, Pengxing He. Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced anti-tumor effects with ferroptosis inducers in NSCLC.
Cell death & disease.
2023 11; 14(11):716. doi:
10.1038/s41419-023-06238-5. [PMID: 37923740] - Qinjuan Wu, Xin Li, Menghong Long, Xianfeng Xie, Qing Liu. Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma.
Scientific reports.
2023 10; 13(1):18642. doi:
10.1038/s41598-023-46057-4. [PMID: 37903971] - Chaoying Kuang, Dandan Li, Xianqing Zhou, Hua Lin, Ruohan Zhang, Huixuan Xu, Shaoying Huang, Fang Tang, Fanna Liu, Donge Tang, Yong Dai. Proteomic analysis of lysine 2-hydroxyisobutyryl in SLE reveals protein modification alteration in complement and coagulation cascades and platelet activation Pathways.
BMC medical genomics.
2023 10; 16(1):247. doi:
10.1186/s12920-023-01656-y. [PMID: 37845672] - Ying Zhang, Chuan Li, Qiushi Wei, Qiang Yuan, Wei He, Ning Zhang, Yiping Dong, Zhenhao Jing, Leilei Zhang, Haibin Wang, Xiangyang Cao. MiRNA320a Inhibitor-Loaded PLGA-PLL-PEG Nanoparticles Contribute to Bone Regeneration in Trauma-Induced Osteonecrosis Model of the Femoral Head.
Tissue engineering and regenerative medicine.
2023 Oct; ?(?):. doi:
10.1007/s13770-023-00580-7. [PMID: 37828392] - João Albuquerque, Ana R Neves, Ingrid Van Dorpe, António J M Fonseca, Ana R J Cabrita, Salette Reis. Production of rumen- and gastrointestinal-resistant nanoparticles to deliver lysine to dairy cows.
Scientific reports.
2023 10; 13(1):16667. doi:
10.1038/s41598-023-43865-6. [PMID: 37794129] - Sara Cutroneo, Barbara Prandi, Andrea Faccini, Nicoletta Pellegrini, Stefano Sforza, Tullia Tedeschi. Comparison of protein quality and digestibility between plant-based and meat-based burgers.
Food research international (Ottawa, Ont.).
2023 10; 172(?):113183. doi:
10.1016/j.foodres.2023.113183. [PMID: 37689935] - Matthew Hurd, Jeffrey Pino, Kay Jang, Michael M Allevato, Marina Vorontchikhina, Wataru Ichikawa, Yifan Zhao, Ryan Gates, Emily Villalpando, Michael J Hamilton, Francesco Faiola, Songqin Pan, Yue Qi, Yu-Wen Hung, Thomas Girke, David Ann, Victoria Seewaldt, Ernest Martinez. MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survival.
Genes & development.
2023 10; 37(19-20):865-882. doi:
10.1101/gad.350736.123. [PMID: 37852796] - Wendan Zhang, Honghong Jiang, Pengli Huang, Gaosong Wu, Qun Wang, Xin Luan, Hongwei Zhang, Dianping Yu, Hongru Wang, Dong Lu, Haonan Wang, Huazhang An, Sanhong Liu, Weidong Zhang. Dracorhodin targeting CMPK2 attenuates inflammation: A novel approach to sepsis therapy.
Clinical and translational medicine.
2023 10; 13(10):e1449. doi:
10.1002/ctm2.1449. [PMID: 37859535] - Huaqian You, Shiqing Li, Yiwen Chen, Junjie Lin, Zixuan Wang, Mans Dennis, Changyu Li, Dongfeng Yang. Global proteome and lysine succinylation analyses provide insights into the secondary metabolism in Salvia miltiorrhiza.
Journal of proteomics.
2023 09; 288(?):104959. doi:
10.1016/j.jprot.2023.104959. [PMID: 37478968] - Héctor F Escobar-Morreale, María Ángeles Martínez-García, María Insenser, Nicolau Cañellas, Xavier Correig, Manuel Luque-Ramírez. Serum metabolomics profiling by proton nuclear magnetic resonance spectrometry of the response to single oral macronutrient challenges in women with polycystic ovary syndrome (PCOS) compared with male and female controls.
Biology of sex differences.
2023 09; 14(1):62. doi:
10.1186/s13293-023-00547-2. [PMID: 37736753] - Meiyi Li, Edward S Gasanoff. Cationic Proteins Rich in Lysine Residue Trigger Formation of Non-bilayer Lipid Phases in Model and Biological Membranes: Biophysical Methods of Study.
The Journal of membrane biology.
2023 Sep; ?(?):. doi:
10.1007/s00232-023-00292-y. [PMID: 37735238] - Izumi Yotsui, Hidenori Matsui, Shingo Miyauchi, Hidekazu Iwakawa, Katharina Melkonian, Titus Schlüter, Santiago Michavila, Takehiko Kanazawa, Yuko Nomura, Sara Christina Stolze, Hyung-Woo Jeon, Yijia Yan, Anne Harzen, Shigeo S Sugano, Makoto Shirakawa, Ryuichi Nishihama, Yasunori Ichihashi, Selena Gimenez Ibanez, Ken Shirasu, Takashi Ueda, Takayuki Kohchi, Hirofumi Nakagami. LysM-mediated signaling in Marchantia polymorpha highlights the conservation of pattern-triggered immunity in land plants.
Current biology : CB.
2023 09; 33(17):3732-3746.e8. doi:
10.1016/j.cub.2023.07.068. [PMID: 37619565] - Alexey Rayevsky, Elijah Bulgakov, Mohsen Sharifi, Dariya Samofalova, Daniil Ozheredov, Pavel Karpov, Sergio Pantano, Yaroslav Blume. In silico induced effect of N-ε-lysine acetylation on microtubule stability and subsequent interaction of microtubule-associated proteins.
Cell biology international.
2023 Sep; 47(9):1547-1557. doi:
10.1002/cbin.12052. [PMID: 37272280] - Mengyang Niu, Xuan Chen, Wen Zhou, Youyou Guo, Xingxing Yuan, Jin Cui, Zhenguo Shen, Nana Su. Multi-omics analysis provides insights intro lysine accumulation in quinoa (Chenopodium quinoa Willd.) sprouts.
Food research international (Ottawa, Ont.).
2023 Sep; 171(?):113026. doi:
10.1016/j.foodres.2023.113026. [PMID: 37330848] - Sushmita Seni, Roshan Kumar Singh, Manoj Prasad. Dynamics of epigenetic control in plants via SET domain containing proteins: Structural and functional insights.
Biochimica et biophysica acta. Gene regulatory mechanisms.
2023 09; 1866(3):194966. doi:
10.1016/j.bbagrm.2023.194966. [PMID: 37532097] - Bin Chen, Zhicheng Wang, Mengjia Jiao, Jin Zhang, Jie Liu, Dongmei Zhang, Yanbin Li, Guoning Wang, Huifeng Ke, Qiuxia Cui, Jun Yang, Zhengwen Sun, Qishen Gu, Xingyi Wang, Jinhua Wu, Liqiang Wu, Guiyin Zhang, Xingfen Wang, Zhiying Ma, Yan Zhang. Lysine 2-Hydroxyisobutyrylation- and Succinylation-Based Pathways Act Inside Chloroplasts to Modulate Plant Photosynthesis and Immunity.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2023 09; 10(27):e2301803. doi:
10.1002/advs.202301803. [PMID: 37492013] - Aditya Kumar, Ankush Prasad, Michaela Sedlářová, Pavel Pospíšil. Malondialdehyde enhances PsbP protein release during heat stress in Arabidopsis.
Plant physiology and biochemistry : PPB.
2023 Sep; 202(?):107984. doi:
10.1016/j.plaphy.2023.107984. [PMID: 37669610] - Jing Gao, Chenglin Huang, Linghui Kong, Wugang Zhou, Mengwei Sun, Tong Wei, Weili Shen. SIRT3 Regulates Clearance of Apoptotic Cardiomyocytes by Deacetylating Frataxin.
Circulation research.
2023 Aug; ?(?):. doi:
10.1161/circresaha.123.323160. [PMID: 37646156] - Hao-Long He, Guo-Shan Zhang, Shan-Feng Xiao, Hong-Hua Liu, Huan Zhong, Xiao-Rong Chang, Qiong Liu, Mi Liu. [Effects of moxibustion at "Tianshu"（ST25） and "Shangjuxu" （ST37） on colonic metabolites and inflammatory factors in rats with Crohn's disease].
Zhen ci yan jiu = Acupuncture research.
2023 Aug; 48(8):736-45. doi:
10.13702/j.1000?0607.20221276. [PMID: 37614131] - Pei Liu, Xiao-Ying Tan, Huang-Qin Zhang, Ke-Lei Su, Er-Xin Shang, Qing-Ling Xiao, Sheng Guo, Jin-Ao Duan. Optimal compatibility proportional screening of Trichosanthis Pericarpium - Trichosanthis Radix and its anti - Inflammatory components effect on experimental zebrafish and coughing mice.
Journal of ethnopharmacology.
2023 Aug; ?(?):117096. doi:
10.1016/j.jep.2023.117096. [PMID: 37634750] - Wei Xue, Wengang Jian, Yuyang Meng, Tengda Wang, Licheng Cai, Yongchun Yu, Yipeng Yu, Zhinan Xia, Cheng Zhang. Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC.
Cell death & disease.
2023 08; 14(8):539. doi:
10.1038/s41419-023-06057-8. [PMID: 37604811] - Wanyue Xu, Yue Yu, Juli Jing, Zhen Wu, Xumin Zhang, Chenjiang You, Hong Ma, Gregory P Copenhaver, Yan He, Yingxiang Wang. SCFRMF mediates degradation of the meiosis-specific recombinase DMC1.
Nature communications.
2023 08; 14(1):5044. doi:
10.1038/s41467-023-40799-5. [PMID: 37598222] - Weixia Sun, Mengshu Jia, Yingyan Feng, Xiawei Cheng. Lactate is a bridge linking glycolysis and autophagy through lactylation.
Autophagy.
2023 Aug; ?(?):. doi:
10.1080/15548627.2023.2246356. [PMID: 37565742] - Mao-Song Pei, Hai-Nan Liu, Tong-Lu Wei, Da-Long Guo. Proteome-Wide Identification of Non-histone Lysine Methylation during Grape Berry Ripening.
Journal of agricultural and food chemistry.
2023 Aug; 71(31):12140-12152. doi:
10.1021/acs.jafc.3c03144. [PMID: 37503871] - Dan Li, Tiantian Tian, Chung-Nga Ko, Chao Yang. Prospect of targeting lysine methyltransferase NSD3 for tumor therapy.
Pharmacological research.
2023 08; 194(?):106839. doi:
10.1016/j.phrs.2023.106839. [PMID: 37400043] - Cindy Le Bourgot, Xinxin Liu, Caroline Buffière, Noureddine Hafanaoui, Lorène Salis, Corinne Pouyet, Dominique Dardevet, Didier Rémond. Development of a protein food based on texturized wheat proteins, with high protein digestibility and improved lysine content.
Food research international (Ottawa, Ont.).
2023 08; 170(?):112978. doi:
10.1016/j.foodres.2023.112978. [PMID: 37316015] - Xiao Wang, Yannan Wang, Simiao Liu, Yi Zhang, Ke Xu, Liting Ji, Roger D Kornberg, Heqiao Zhang. Class I histone deacetylase complex: Structure and functional correlates.
Proceedings of the National Academy of Sciences of the United States of America.
2023 07; 120(30):e2307598120. doi:
10.1073/pnas.2307598120. [PMID: 37459529] - Guanghui Tang, Wei Wang, Xuan Wang, Ke Ding, SoFong Cam Ngan, Jiao-Yu Chen, Siu Kwan Sze, Liqian Gao, Peiyan Yuan, Xiaoyun Lu, Shao Q Yao. Cell-active, irreversible covalent inhibitors that selectively target the catalytic lysine of EGFR by using fluorosulfate-based SuFEx chemistry.
European journal of medicinal chemistry.
2023 Jul; 259(?):115671. doi:
10.1016/j.ejmech.2023.115671. [PMID: 37499291] - Yanqiang Liu, Ziwen Zhang, Ni Zuo, Weihong Jiang, Yang Gu. Programmable Acetylation Modification of Bacterial Proteins by a Cas12a-Guided Acetyltransferase.
ACS synthetic biology.
2023 07; 12(7):2135-2146. doi:
10.1021/acssynbio.3c00211. [PMID: 37358911] - Vikrant Kumar Sinha, Yi Zhang, Longxia Xu, Yu-Wen Chen, Sarah Picaud, Mohamad Zandian, Soumi Biswas, Panagis Filippakopoulos, Shu-Ping Wang, Xiaobing Shi, Tatiana G Kutateladze. Histone H4K16ac Binding Function of the Triple PHD Finger Cassette of MLL4.
Journal of molecular biology.
2023 Jul; ?(?):168212. doi:
10.1016/j.jmb.2023.168212. [PMID: 37481158] - Yanlong Li, Miao Chen, Aamir Hamid Khan, Yizan Ma, Xin He, Jing Yang, Rui Zhang, Huanhuan Ma, Chunyang Zuo, Yawei Li, Jie Kong, Maojun Wang, Longfu Zhu, Xianlong Zhang, Ling Min. Histone H3 lysine 27 trimethylation suppresses jasmonate biosynthesis and signaling to affect male fertility under high temperature in cotton.
Plant communications.
2023 Jul; ?(?):100660. doi:
10.1016/j.xplc.2023.100660. [PMID: 37455428] - Yu Sui, Xiaojiang Duan, Jingming Zhang, Yingming Chu, Xing Yang. Synthesis and characterization of a novel 68Ga-labeled p-bromobenzyl lysine-urea-ODAP PSMA inhibitor.
Bioorganic & medicinal chemistry letters.
2023 07; 91(?):129382. doi:
10.1016/j.bmcl.2023.129382. [PMID: 37348571] - Firoz Hossain, Sunil K Jaiswal, Vignesh Muthusamy, Rajkumar U Zunjare, Subhra J Mishra, Gulab Chand, Vinay Bhatt, Jayant S Bhat, Abhijit K Das, Hema S Chauhan, Hari S Gupta. Enhancement of nutritional quality in maize kernel through marker-assisted breeding for vte4, crtRB1, and opaque2 genes.
Journal of applied genetics.
2023 Jul; ?(?):. doi:
10.1007/s13353-023-00768-6. [PMID: 37450243] - Carolina Añazco, Janin Riedelsberger, Lorenzo Vega-Montoto, Armando Rojas. Exploring the Interplay between Polyphenols and Lysyl Oxidase Enzymes for Maintaining Extracellular Matrix Homeostasis.
International journal of molecular sciences.
2023 Jul; 24(13):. doi:
10.3390/ijms241310985. [PMID: 37446164] - Yan Gao, Xinlei Sheng, Doudou Tan, SunJoo Kim, Soyoung Choi, Sanjita Paudel, Taeho Lee, Cong Yan, Minjia Tan, Kyu Min Kim, Sam Seok Cho, Sung Hwan Ki, He Huang, Yingming Zhao, Sangkyu Lee. Identification of Histone Lysine Acetoacetylation as a Dynamic Post-Translational Modification Regulated by HBO1.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2023 Jun; ?(?):e2300032. doi:
10.1002/advs.202300032. [PMID: 37382194] - Uyen Thu Nguyen, Shashank K Pandey, Jungmook Kim. LBD18 and IAA14 antagonistically interact with ARF7 via the invariant Lys and acidic residues of the OPCA motif in the PB1 domain.
Planta.
2023 Jun; 258(2):26. doi:
10.1007/s00425-023-04183-3. [PMID: 37354348] - Umair Ahsan, Eren Kuter, Komal Khan, Ifrah Raza, Ali Çalık, Hande Sultan Şahiner, Özcan Cengiz. Effect of phased reduction of dietary digestible lysine density on growth performance, thigh meat, and biomechanical characteristics of tibia in broiler chickens.
Tropical animal health and production.
2023 Jun; 55(4):248. doi:
10.1007/s11250-023-03660-x. [PMID: 37351695] - Farshad Teymoori, Golaleh Asghari, Sanaz Hoseinpour, Sajjad Roosta, Maryam Bordbar, Parvin Mirmiran, Narges Sarbazi, Fereidoun Azizi. Dietary amino acids and anthropometric indices: Tehran Lipid and Glucose Study.
Archives of endocrinology and metabolism.
2023 Jun; 67(6):e000646. doi:
10.20945/2359-3997000000646. [PMID: 37364148] - Ru Li, Fengyue Chen, Shuangcai Li, Luying Yuan, Lijiu Zhao, Shigen Tian, Baoshan Chen. Comparative acetylomic analysis reveals differentially acetylated proteins regulating fungal metabolism in hypovirus-infected chestnut blight fungus.
Molecular plant pathology.
2023 Jun; ?(?):. doi:
10.1111/mpp.13358. [PMID: 37278715] - Qiutao Xu, Yaping Yue, Biao Liu, Zhengting Chen, Xuan Ma, Jing Wang, Yu Zhao, Dao-Xiu Zhou. ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation.
Nature communications.
2023 06; 14(1):3265. doi:
10.1038/s41467-023-39101-4. [PMID: 37277331] - Mengshu Jia, Xiao Yue, Weixia Sun, Qianjun Zhou, Cheng Chang, Weihua Gong, Jian Feng, Xie Li, Ruonan Zhan, Kemin Mo, Lijuan Zhang, Yajie Qian, Yuying Sun, Aoxue Wang, Yejun Zou, Weicai Chen, Yan Li, Li Huang, Yi Yang, Yuzheng Zhao, Xiawei Cheng. ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation.
Science advances.
2023 Jun; 9(22):eadg4993. doi:
10.1126/sciadv.adg4993. [PMID: 37267363] - Jeremy E Chojnacki, Laura Scheinost, Yansong Wang, Maja Köhn. Membrane targeting with palmitoylated lysine added to PP1-disrupting peptide induces PP1-independent signaling.
Journal of peptide science : an official publication of the European Peptide Society.
2023 Jun; 29(6):e3469. doi:
10.1002/psc.3469. [PMID: 36525306] - Prabu Gnanasekaran, Neha Gupta, Kalaiarasan Ponnusamy, Ragunathan Devendran, Biju George, Supriya Chakraborty. Betasatellite-encoded βC1 protein regulates helper virus accumulation by interfering with the ATP hydrolysis activity of geminivirus-encoded replication initiator protein.
The Journal of general virology.
2023 Jun; 104(6):. doi:
10.1099/jgv.0.001866. [PMID: 37326617] - Leo Man-Yuen Lee, Zhi-Qiang Lin, Lu-Xi Zheng, Yi-Fan Tu, Yik-Hing So, Xiu-Hua Zheng, Tie-Jun Feng, Xi-Yue Wang, Wai-Ting Wong, Yun-Chung Leung. Lysine Deprivation Suppresses Adipogenesis in 3T3-L1 Cells: A Transcriptome Analysis.
International journal of molecular sciences.
2023 May; 24(11):. doi:
10.3390/ijms24119402. [PMID: 37298352] - Nicolas Nalpas, Takfarinas Kentache, Emmanuelle Dé, Julie Hardouin. Lysine Trimethylation in Planktonic and Pellicle Modes of Growth in Acinetobacter baumannii.
Journal of proteome research.
2023 May; ?(?):. doi:
10.1021/acs.jproteome.3c00097. [PMID: 37227083] - Shengrong Li, Chengjun Zhu, Qian Zhao, Zhi-Min Zhang, Pinghua Sun, Zhengqiu Li. Ynamide Coupling Reagent for the Chemical Cross-Linking of Proteins in Live Cells.
ACS chemical biology.
2023 May; ?(?):. doi:
10.1021/acschembio.3c00149. [PMID: 37231651] - Pan-Pan Tian, Yu-Lin Zhang, Jing-Ling Huang, Wang-Yan Li, Xiang-Dong Liu. Arsenophonus Interacts with Buchnera to Improve Growth Performance of Aphids under Amino Acid Stress.
Microbiology spectrum.
2023 May; ?(?):e0179223. doi:
10.1128/spectrum.01792-23. [PMID: 37222634] - Chaoyu Zhai, Steven M Lonergan, Elisabeth J Huff-Lonergan, Logan G Johnson, Kitty Brown, Jessica E Prenni, Mahesh N Nair. Lipid Peroxidation Products Influence Calpain-1 Functionality In Vitro by Covalent Binding.
Journal of agricultural and food chemistry.
2023 May; 71(20):7836-7846. doi:
10.1021/acs.jafc.3c01225. [PMID: 37167568] - Yueqing Su, Chao Deng, Xuemei Liu, Jiamei Lian. Epigenetic Histone Methylation of PPARγ and CPT1A Signaling Contributes to Betahistine Preventing Olanzapine-Induced Dyslipidemia.
International journal of molecular sciences.
2023 May; 24(11):. doi:
10.3390/ijms24119143. [PMID: 37298094] - Emily R R Mackie, Andrew S Barrow, Marie-Claire Giel, Mark D Hulett, Anthony R Gendall, Santosh Panjikar, Tatiana P Soares da Costa. Repurposed inhibitor of bacterial dihydrodipicolinate reductase exhibits effective herbicidal activity.
Communications biology.
2023 05; 6(1):550. doi:
10.1038/s42003-023-04895-y. [PMID: 37217566] - Shuhao Li, Yuqi Zhou, Craig A Downs, Song Yuan, Maomao Hou, Qingming Li, Xin Zhong, Fenglin Zhong. Proteomics and Lysine Acetylation Modification Reveal the Responses of Pakchoi (Brassica rapa L. ssp. chinensis) to Oxybenzone Stress.
Journal of agricultural and food chemistry.
2023 May; ?(?):. doi:
10.1021/acs.jafc.2c07852. [PMID: 37216206] - Xiaoqin Liao, Xingsu Zhang, Xin Li, Yuchen Tian, Qing Yang, Yongyan Wang, Si Tang, Xuanling Luo, Fan Zhang, Lei Zhang, Beibei Jiang, Qinglin Liu. Lysine malonylation of DgnsLIPID TRANSFER PROTEIN1 at the K81 site improves cold resistance in chrysanthemum.
Plant physiology.
2023 May; ?(?):. doi:
10.1093/plphys/kiad285. [PMID: 37202366]