Propranolol (BioDeep_00000002284)

 

Secondary id: BioDeep_00000397477

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


[2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine

化学式: C16H21NO2 (259.1572)
中文名称: 心得安(普萘洛尔), 盐酸普萘洛尔
谱图信息: 最多检出来源 Homo sapiens(blood) 21.58%

分子结构信息

SMILES: CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O
InChI: InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3

描述信息

Propranolol is a widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. --PubChem; Propranolol is a highly lipophilic drug achieving high concentrations in the brain. The duration of action of a single oral dose is longer than the half-life indicates and may be up to 12 hours, if the single dose is high enough (e.g. 80 mg). Effective plasma concentrations are between 10-100 ng/mL. -- Wikipedia; It was the first successful beta blocker developed. Propranolol is commonly marketed by Wyeth under the trade name Inderal.
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. --PubChem; Propranolol is a highly lipophilic drug achieving high concentrations in the brain. The duration of action of a single oral dose is longer than the half-life indicates and may be up to 12 hours, if the single dose is high enough (e.g. 80 mg). Effective plasma concentrations are between 10-100 ng/mL. -- Wikipedia; It was the first successful beta blocker developed. Propranolol is commonly marketed by Wyeth under the trade name Inderal. [HMDB]
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AA - Beta blocking agents, non-selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 171
KEIO_ID P192; [MS2] KO009171
KEIO_ID P192
Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].
Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].
Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

同义名列表

27 个代谢物同义名

[2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine; 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol; 1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol; 1-(Isopropylamino)-3-(1-naphthyloxy)propan-2-ol; Hydrochloride, propranolol; Propranolol hydrochloride; beta-Propranolol; Dexpropranolol; Β-propranolol; b-Propranolol; Propranololum; Propranololo; propranolol; Euprovasin; Propanalol; Propanolol; Anapriline; Avlocardyl; Anaprilin; Propanix; Betadren; Dociton; Rexigen; Obsidan; Inderal; Obzidan; Propranolol



数据库引用编号

51 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ACE, ANG, CALCA, CYP2D6, DBH, POMC, TH
Endoplasmic reticulum membrane 2 CYP1A2, CYP2D6
Nucleus 2 ANG, TH
cytosol 3 ANG, SST, TH
dendrite 2 HTR1A, TH
nucleoplasm 3 ATP2B1, SCN5A, SCNN1G
Cell membrane 6 ABCB1, ACE, AGTR2, ATP2B1, HTR1A, SCN5A
Cell projection, axon 1 TH
Multi-pass membrane protein 7 ABCB1, AGTR2, ATP2B1, CACNA1I, HTR1A, SCN5A, SCNN1G
Synapse 3 ATP2B1, DBH, HTR1A
cell junction 1 SCN5A
cell surface 2 ABCB1, SCN5A
glutamatergic synapse 1 ATP2B1
growth cone 1 ANG
neuronal cell body 3 ANG, CALCA, SST
presynaptic membrane 1 ATP2B1
sarcolemma 1 SCN5A
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 11 ABCB1, ACE, AGTR2, ATP2B1, CACNA1I, EDNRA, F2, HTR1A, REN, SCN5A, SCNN1G
synaptic vesicle membrane 1 ATP2B1
terminal bouton 2 CALCA, TH
Membrane 8 ABCB1, ACE, ATP2B1, CACNA1I, CYP2D6, DBH, REN, SCN5A
apical plasma membrane 2 ABCB1, SCNN1G
axon 1 TH
basolateral plasma membrane 1 ATP2B1
caveola 1 SCN5A
extracellular exosome 5 ABCB1, ACE, ATP2B1, F2, SCNN1G
endoplasmic reticulum 3 CYP2D6, DBH, SCN5A
extracellular space 9 ACE, ANG, CALCA, DBH, F2, IL6, POMC, REN, SST
perinuclear region of cytoplasm 2 SCN5A, TH
intercalated disc 1 SCN5A
mitochondrion 2 CYP2D6, TH
intracellular membrane-bounded organelle 4 ATP2B1, CYP1A2, CYP2D6, DBH
Microsome membrane 2 CYP1A2, CYP2D6
Single-pass type I membrane protein 1 ACE
Secreted 9 ACE, ANG, CALCA, DBH, F2, IL6, POMC, REN, SST
extracellular region 9 ACE, ANG, CALCA, DBH, F2, IL6, POMC, REN, SST
cytoplasmic side of plasma membrane 1 TH
Single-pass membrane protein 1 CYP2D6
hippocampal mossy fiber to CA3 synapse 1 CALCA
centriolar satellite 1 DBH
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 ACE, SCNN1G
actin cytoskeleton 1 ANG
T-tubule 1 SCN5A
perikaryon 1 TH
Z disc 1 SCN5A
cytoplasmic vesicle 1 TH
nucleolus 2 ANG, SCN5A
Melanosome membrane 1 TH
apical part of cell 1 REN
Single-pass type II membrane protein 1 DBH
Apical cell membrane 2 ABCB1, SCNN1G
Cytoplasm, perinuclear region 2 SCN5A, TH
GABA-ergic synapse 1 SST
basement membrane 1 ANG
collagen-containing extracellular matrix 1 F2
secretory granule 1 POMC
lateral plasma membrane 2 ATP2B1, SCN5A
neuron projection 1 TH
cell projection 1 ATP2B1
Chromosome 1 ANG
brush border membrane 1 ACE
Nucleus, nucleolus 1 ANG
blood microparticle 1 F2
sperm midpiece 1 ACE
Basolateral cell membrane 1 ATP2B1
sodium channel complex 1 SCNN1G
Cell projection, dendrite 1 HTR1A
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 1 ACE
Cell membrane, sarcolemma, T-tubule 1 SCN5A
secretory granule lumen 2 DBH, POMC
secretory granule membrane 1 DBH
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 F2, IL6
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle 1 ANG
immunological synapse 1 ATP2B1
neuronal dense core vesicle 2 CALCA, SST
external side of apical plasma membrane 1 ABCB1
Cytoplasmic vesicle, secretory vesicle membrane 1 DBH
voltage-gated sodium channel complex 1 SCN5A
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
transport vesicle membrane 1 DBH
angiogenin-PRI complex 1 ANG
interleukin-6 receptor complex 1 IL6
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
photoreceptor ribbon synapse 1 ATP2B1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE


文献列表

  • Pattwat Maneewattanapinyo, Chaowalit Monton, Wiwat Pichayakorn, Jirapornchai Suksaeree. Plant leaf mucilage/carrageenan/Eudragit® NE30D blended films: Optimization, characterization, and pharmaceutical application. International journal of biological macromolecules. 2024 Jan; 254(Pt 2):127916. doi: 10.1016/j.ijbiomac.2023.127916. [PMID: 37944740]
  • Juan Zhao, Yu Chen, Zhifen Ding, Yaru Zhou, Ruiqing Bi, Ziting Qin, Lei Yang, Peng Sun, Qiping Sun, Guang Chen, Daiyuan Sun, Xianya Jiang, Lu Zheng, Xiao-Lin Chen, Hu Wan, Guanghui Wang, Qiang Li, Huailong Teng, Guotian Li. Identification of propranolol and derivatives that are chemical inhibitors of phosphatidate phosphatase as potential broad-spectrum fungicides. Plant communications. 2023 Aug; ?(?):100679. doi: 10.1016/j.xplc.2023.100679. [PMID: 37653727]
  • Shuming Chen, Xuekai Zhao, Junjie Huang, Na Lin, Qianhui Xu, Jianwei Chen, Jianqiang Huang, Lie Wang, Chen Lin, Zaizhong Zhang. The effects of propranolol on the biology and Notch signaling pathway of human umbilical vein endothelial cells. Medicine. 2023 Aug; 102(32):e34672. doi: 10.1097/md.0000000000034672. [PMID: 37565874]
  • Dison Stracke Pfingsten Franco, Jordana Georgin, Claudete Gindri Ramos, Salma Martinez Eljaiek, Daniel Romero Badillo, Anelise Hoch Paschoalin de Oliveira, Daniel Allasia, Lucas Meili. The Synthesis and Evaluation of Porous Carbon Material from Corozo Fruit (Bactris guineensis) for Efficient Propranolol Hydrochloride Adsorption. Molecules (Basel, Switzerland). 2023 Jul; 28(13):. doi: 10.3390/molecules28135232. [PMID: 37446896]
  • Paula Mayara Morais da Silva, Gilberto Dias de Alkimin, Natália Gabriele Camparotto, Patricia Prediger, Bruno Nunes. Toxicological effects resulting from co-exposure to nanomaterials and to a β-blocker pharmaceutical drug in the non-target macrophyte species Lemna minor. Environmental pollution (Barking, Essex : 1987). 2023 Apr; 322(?):121166. doi: 10.1016/j.envpol.2023.121166. [PMID: 36738879]
  • Ming Yi, Jinxiu Lou, Wanlu Zhu, Dan Li, Pingfeng Yu, Huijie Lu. Mechanism of β-blocker biodegradation by wastewater microorganisms. Journal of hazardous materials. 2023 02; 444(Pt A):130338. doi: 10.1016/j.jhazmat.2022.130338. [PMID: 36417780]
  • Yu Lei, Livio Carlucci, Huub Rijnaarts, Alette Langenhoff. Phytoremediation of micropollutants by Phragmites australis, Typha angustifolia, and Juncus effuses. International journal of phytoremediation. 2023; 25(1):82-88. doi: 10.1080/15226514.2022.2057422. [PMID: 35414315]
  • Wei-Ping He, Jin-Cheng Li, Gao-Ming Wang. [Effect of total flavonoids of buckwheat flower and leaf on myocardial cell apoptosis and Wnt/β-catenin/PPARγ pathway in arrhythmic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jan; 48(1):220-225. doi: 10.19540/j.cnki.cjcmm.20221014.701. [PMID: 36725274]
  • Michela Puxeddu, Jianchao Wu, Ruoli Bai, Michele D'Ambrosio, Marianna Nalli, Antonio Coluccia, Simone Manetto, Alessia Ciogli, Domiziana Masci, Andrea Urbani, Cinzia Fionda, Sonia Coni, Rosa Bordone, Gianluca Canettieri, Chiara Bigogno, Giulio Dondio, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina. Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor. Journal of medicinal chemistry. 2022 12; 65(23):15805-15818. doi: 10.1021/acs.jmedchem.2c01457. [PMID: 36395526]
  • Mahmoud H Teaima, Moaz A Eltabeeb, Mohamed A El-Nabarawi, Menna M Abdellatif. Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation. Drug delivery. 2022 Dec; 29(1):2549-2560. doi: 10.1080/10717544.2022.2100514. [PMID: 35912869]
  • Pandeng Miao, Jie Gan, Jian Zhang, Mingxuan Ma, Xiaoqi Li, Yingxiang Du, Zijie Feng, Liu Zhang. Carboxymethyl-β-cyclodextrin and histidine-zeolitic imidazolate framework-8 used for enantioseparation of three basic drugs in open-tubular capillary electrochromatography. Chirality. 2022 09; 34(9):1209-1218. doi: 10.1002/chir.23480. [PMID: 35678370]
  • Farzaneh Feizi, Ajit K Sarmah, Ropru Rangsivek, Kapish Gobindlal. Adsorptive removal of propranolol under fixed-bed column using magnetic tyre char: Effects of wastewater effluent organic matter and ball milling. Environmental pollution (Barking, Essex : 1987). 2022 Jul; 305(?):119283. doi: 10.1016/j.envpol.2022.119283. [PMID: 35421549]
  • Ramasamy Manikandan, Balamuralikrishnan Balasubramanian, Panneerselvam Punniyakotti, Arumugam Vijaya Anand, Arun Meyyazhagan, Shanmugam Velayuthaprabhu, Rengasamy Lakshminarayanan Rengarajan, Utthapon Issara, Wen-Chao Liu. Cardio-protective effects of terminalia catappa leaves and terminalia chebula fruit extract in doxorubicin-induced cardiomyopathy in rats. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2022 Jul; 27(5):488-495. doi: 10.1080/1354750x.2022.2064550. [PMID: 35400254]
  • Abdolhamid Esmaeeli, Zahra Keshavarz, Firoozeh Dehdar, Majid Assadi, Mohammad Seyedabadi. The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury. Drug and chemical toxicology. 2022 Jul; 45(4):1558-1564. doi: 10.1080/01480545.2020.1846551. [PMID: 33198524]
  • Edward S Wragg, Patrizia Pannucci, Stephen J Hill, Jeanette Woolard, Samantha L Cooper. Involvement of β-adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists. Pharmacology research & perspectives. 2022 06; 10(3):e00975. doi: 10.1002/prp2.975. [PMID: 35643970]
  • Yuefei Ruan, Hongwen Sun, Yichun Lu, Yanwei Zhang, Jiayao Xu, Hongkai Zhu, Yuhe He. Evaluating phospholipid- and protein-water partitioning of two groups of chemicals of emerging concern: Diastereo- and enantioselectivity. Journal of hazardous materials. 2022 05; 430(?):128499. doi: 10.1016/j.jhazmat.2022.128499. [PMID: 35739679]
  • Rozelle Corda, Sophia Chrisomalis-Dring, Sarah Crook, Carrie J Shawber, June K Wu, Paul J Chai. Propranolol treatment for chylothorax after congenital cardiac surgery. The Journal of thoracic and cardiovascular surgery. 2022 05; 163(5):1630-1641.e2. doi: 10.1016/j.jtcvs.2021.09.007. [PMID: 34583843]
  • Nicole Arguelles, Janielle Richards, Ahmed A El-Sherbeni, Sharon Miksys, Rachel F Tyndale. Sex, estrous cycle, and hormone regulation of CYP2D in the brain alters oxycodone metabolism and analgesia. Biochemical pharmacology. 2022 04; 198(?):114949. doi: 10.1016/j.bcp.2022.114949. [PMID: 35143755]
  • Debashish Chowdhury, Luv Bansal, Ashish Duggal, Debabrata Datta, Ankit Mundra, Anand Krishnan, Arun Koul, Anu Gupta. TOP-PRO study: A randomized double-blind controlled trial of topiramate versus propranolol for prevention of chronic migraine. Cephalalgia : an international journal of headache. 2022 04; 42(4-5):396-408. doi: 10.1177/03331024211047454. [PMID: 34579560]
  • Darren M Roberts, Haddijatou K Hughes, Paul S Haber, Graham R D Jones. Variability in insulin pharmacokinetics following high-dose insulin therapy. Clinical toxicology (Philadelphia, Pa.). 2022 Mar; 60(3):389-391. doi: 10.1080/15563650.2021.1967372. [PMID: 34521309]
  • E Bäckström, T Erngren, B-M Fihn, M W Sadiq, W Lindberg, M Fridén, K Grime. Possible Extraction of Drugs from Lung Tissue During Broncho-alveolar Lavage Suggest Uncertainty in the Procedure's Utility for Quantitative Assessment of Airway Drug Exposure. Journal of pharmaceutical sciences. 2022 03; 111(3):852-858. doi: 10.1016/j.xphs.2021.12.004. [PMID: 34890629]
  • Hagar Bessar, Abdalla Hassan Kandil, Noha Mohammed Nasr, Fathia Khattab. Itraconazole versus propranolol: therapeutic and pharmacologic effect on serum angiopoietin-2 in patients with infantile hemangioma. The Journal of dermatological treatment. 2022 Feb; 33(1):105-110. doi: 10.1080/09546634.2019.1687822. [PMID: 31668109]
  • Hae-Jung Yang, Seung-Gon Kim, Eun Hyun Seo, Hyung-Jun Yoon. Amisulpride withdrawal akathisia responding to aripiprazole with propranolol in first-onset psychosis: a case report. BMC psychiatry. 2022 01; 22(1):74. doi: 10.1186/s12888-022-03721-9. [PMID: 35093063]
  • Virginia Albiñana, Lucía Recio-Poveda, Pilar González-Peramato, Luis Martinez-Piñeiro, Luisa María Botella, Angel M Cuesta. Blockade of β2-Adrenergic Receptor Reduces Inflammation and Oxidative Stress in Clear Cell Renal Cell Carcinoma. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031325. [PMID: 35163250]
  • Seong-Ho Ok, Seung Hyun Ahn, Soo Hee Lee, Hyun-Jin Kim, Gyujin Sim, Jin Kyeong Park, Ju-Tae Sohn. Lipid emulsion attenuates propranolol-induced early apoptosis in rat cardiomyoblasts. Human & experimental toxicology. 2022 Jan; 41(?):9603271221110852. doi: 10.1177/09603271221110852. [PMID: 35738838]
  • Ivana Kurćubić, Una-Jovana Vajić, Sandra Cvijić, Milkica Crevar-Sakač, Nataša Bogavac-Stanojević, Zoran Miloradović, Nevena Mihajlović-Stanojević, Milan Ivanov, Danijela Karanović, Đurđica Jovović, Jelena Djuriš. Mucoadhesive buccal tablets with propranolol hydrochloride: Formulation development and in vivo performances in experimental essential hypertension. International journal of pharmaceutics. 2021 Dec; 610(?):121266. doi: 10.1016/j.ijpharm.2021.121266. [PMID: 34752918]
  • Tomoko Kodama, Satoshi Kameshima, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki. Eukaryotic elongation factor 2 kinase inhibitor, A484954 induces diuretic effect via renal vasorelaxation in spontaneously hypertensive rats. European journal of pharmacology. 2021 Dec; 913(?):174637. doi: 10.1016/j.ejphar.2021.174637. [PMID: 34801528]
  • Deshan F Sebaratnam, Ana L Rodríguez Bandera, Li-Chuen F Wong, Orli Wargon. Infantile hemangioma. Part 2: Management. Journal of the American Academy of Dermatology. 2021 12; 85(6):1395-1404. doi: 10.1016/j.jaad.2021.08.020. [PMID: 34419523]
  • Wael S Ibrahim, Hoda M S Ahmed, Amr A A Mahmoud, Mona F Mahmoud, Islam A A E-H Ibrahim. Propranolol and low-dose isoproterenol ameliorate insulin resistance, enhance β-arrestin2 signaling, and reduce cardiac remodeling in high-fructose, high-fat diet-fed mice: Comparative study with metformin. Life sciences. 2021 Dec; 286(?):120055. doi: 10.1016/j.lfs.2021.120055. [PMID: 34662551]
  • Mehdi Farshchian, Geoffrey A Potts. Transient hypertriglyceridaemia associated with propranolol for treatment of infantile hemangioma. The Australasian journal of dermatology. 2021 Nov; 62(4):e580-e581. doi: 10.1111/ajd.13669. [PMID: 34293182]
  • Andrew K Evans, Heui Hye Park, Nay Lui Saw, Kratika Singhal, Gaku Ogawa, Ryan D Leib, Mehrdad Shamloo. Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice. Neurobiology of aging. 2021 10; 106(?):241-256. doi: 10.1016/j.neurobiolaging.2021.06.012. [PMID: 34320462]
  • Georgios N Kalambokis, Maria Christaki, Ilias Tsiakas, Grigorios Despotis, Sempastien Fillipas-Ntekouan, Andreas Fotopoulos, Spyridon Tsiouris, Xanthi Xourgia, Lampros Lakkas, Konstantinos Pappas, Lampros K Michalis, Fotini Sergianiti, Gerasimos Baltayiannis, Dimitrios Christodoulou, Christina Koustousi, Nikolaos Aggelis, Haralampos Milionis. Conversion of Propranolol to Carvedilol Improves Renal Perfusion and Outcome in Patients With Cirrhosis and Ascites. Journal of clinical gastroenterology. 2021 09; 55(8):721-729. doi: 10.1097/mcg.0000000000001431. [PMID: 32991355]
  • Kathleen E Singer, Taylor E Wallen, Mackenzie C Morris, Emily McGlone, Sabre Stevens-Topie, Ryan Earnest, Michael D Goodman. Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI. The journal of trauma and acute care surgery. 2021 08; 91(2S Suppl 2):S89-S98. doi: 10.1097/ta.0000000000003259. [PMID: 33938511]
  • Sheelan Ahmad, Daniel Baker, Darragh Murnane, Neil Spooner, Ute Gerhard. Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis. Bioanalysis. 2021 Jul; 13(14):1101-1111. doi: 10.4155/bio-2021-0109. [PMID: 34275331]
  • Ali Hatefi, Ahmad Zare Shahneh, Zarbakht Ansari Pirsaraie, Ali Mohammad Alizadeh, Mohammad Pouya Atashnak, Reza Masoudi, Frederic Pio. The stimulation and inhibition of beta-2 adrenergic receptor on the inflammatory responses of ovary and immune system in the aged laying hens. BMC veterinary research. 2021 May; 17(1):195. doi: 10.1186/s12917-021-02892-z. [PMID: 34022889]
  • Benjamin J Buckley, Ashraf Aboelela, Hiwa Majed, Richard S Bujaroski, Karen L White, Andrew K Powell, Wen Wang, Kasiram Katneni, Jessica Saunders, David M Shackleford, Susan A Charman, Gregory M Cook, Michael J Kelso, Marie Ranson. Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride. Bioorganic & medicinal chemistry. 2021 05; 37(?):116116. doi: 10.1016/j.bmc.2021.116116. [PMID: 33799173]
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