Tetraconazole (BioDeep_00000002256)

 

Secondary id: BioDeep_00000419490

human metabolite blood metabolite Industrial Pollutants


代谢物信息卡片


2-(2,4-Dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl-1,1,2,2-tetrafluoroethylether

化学式: C13H11Cl2F4N3O (371.0215)
中文名称: 氟醚唑, 四环唑
谱图信息: 最多检出来源 Homo sapiens(blood) 22.96%

分子结构信息

SMILES: C1=CC(=C(C=C1Cl)Cl)C(CN2C=NC=N2)COC(C(F)F)(F)F
InChI: InChI=1S/C13H11Cl2F4N3O/c14-9-1-2-10(11(15)3-9)8(4-22-7-20-6-21-22)5-23-13(18,19)12(16)17/h1-3,6-8,12H,4-5H2

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1352; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9343; ORIGINAL_PRECURSOR_SCAN_NO 9342
CONFIDENCE standard compound; INTERNAL_ID 1352; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9319; ORIGINAL_PRECURSOR_SCAN_NO 9317
CONFIDENCE standard compound; INTERNAL_ID 1352; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9334; ORIGINAL_PRECURSOR_SCAN_NO 9331
CONFIDENCE standard compound; INTERNAL_ID 1352; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9370; ORIGINAL_PRECURSOR_SCAN_NO 9366
CONFIDENCE standard compound; INTERNAL_ID 1352; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9361; ORIGINAL_PRECURSOR_SCAN_NO 9360
CONFIDENCE standard compound; INTERNAL_ID 1352; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9358; ORIGINAL_PRECURSOR_SCAN_NO 9356
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3723
D016573 - Agrochemicals
D010575 - Pesticides

同义名列表

6 个代谢物同义名

2-(2,4-Dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl-1,1,2,2-tetrafluoroethylether; 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1H-1,2,4-triazole; Tetraconazole; Eminent; TTZ; Tetraconazole



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, AHR, ANG, ATF2, CCND1, HPGDS, MAPK8, NR1I3, VEGFA
Peripheral membrane protein 5 ACHE, CYP11A1, CYP1B1, HSD17B6, SDHB
Endoplasmic reticulum membrane 2 CYP19A1, CYP1B1
Mitochondrion membrane 1 CYP11A1
Nucleus 9 ACHE, AHR, ANG, ATF2, CCND1, MAPK8, NR1I3, PCNA, VEGFA
cytosol 6 AHR, ANG, CCND1, HPGDS, MAPK8, NR1I3
mitochondrial membrane 1 SDHB
nuclear body 1 PCNA
centrosome 2 CCND1, PCNA
nucleoplasm 8 AHR, ATF2, CCND1, HPGDS, MAPK8, NR1I3, PCNA, SDHB
RNA polymerase II transcription regulator complex 1 ATF2
Cell membrane 3 ABCB1, ACHE, KCNH2
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 4 ABCB1, CYP19A1, KCNH2, SDHC
Synapse 2 ACHE, MAPK8
cell surface 4 ABCB1, ACHE, KCNH2, VEGFA
Golgi apparatus 2 ACHE, VEGFA
growth cone 1 ANG
mitochondrial inner membrane 3 CYP11A1, SDHB, SDHC
neuromuscular junction 1 ACHE
neuronal cell body 1 ANG
plasma membrane 4 ABCB1, ACHE, KCNH2, SDHB
Membrane 8 ABCB1, ACHE, CYP11A1, CYP19A1, CYP1B1, KCNH2, SDHC, VEGFA
apical plasma membrane 1 ABCB1
axon 1 MAPK8
extracellular exosome 3 ABCB1, BMP3, PCNA
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 CYP19A1, HSD17B6, VEGFA
extracellular space 5 ACHE, ANG, BMP3, IL17A, VEGFA
perinuclear region of cytoplasm 2 ACHE, KCNH2
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
mitochondrion 4 CYP11A1, CYP1B1, SDHB, SDHC
protein-containing complex 1 AHR
intracellular membrane-bounded organelle 3 CYP1B1, HPGDS, HSD17B6
Microsome membrane 3 CYP19A1, CYP1B1, HSD17B6
Secreted 5 ACHE, ANG, BMP3, IL17A, VEGFA
extracellular region 5 ACHE, ANG, BMP3, IL17A, VEGFA
mitochondrial outer membrane 1 ATF2
mitochondrial matrix 2 CYP11A1, SDHB
Extracellular side 1 ACHE
transcription regulator complex 1 AHR
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
external side of plasma membrane 1 IL17A
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
nucleolus 1 ANG
Apical cell membrane 1 ABCB1
Mitochondrion inner membrane 3 CYP11A1, SDHB, SDHC
Matrix side 1 SDHB
Cytoplasm, cytoskeleton 1 NR1I3
extracellular matrix 1 VEGFA
basement membrane 2 ACHE, ANG
secretory granule 1 VEGFA
chromatin 4 AHR, ATF2, NR1I3, PCNA
Chromosome 1 ANG
cytoskeleton 1 NR1I3
Nucleus, nucleolus 1 ANG
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 ATF2
monoatomic ion channel complex 1 KCNH2
aryl hydrocarbon receptor complex 1 AHR
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
side of membrane 1 ACHE
replication fork 1 PCNA
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 1 KCNH2
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
respiratory chain complex II (succinate dehydrogenase) 2 SDHB, SDHC
nuclear lamina 1 PCNA
synaptic cleft 1 ACHE
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, PCNA
angiogenin-PRI complex 1 ANG
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
H4 histone acetyltransferase complex 1 ATF2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
cyclin D1-CDK6 complex 1 CCND1
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR


文献列表

  • Anthony P Keinath, Gabriel Rennberger, Patrick Wechter. Widespread Resistance to Tebuconazole and Cross-Resistance to Other DMI Fungicides in Stagonosporopsis citrulli Isolated from Watermelon in South Carolina. Plant disease. 2023 Jun; ?(?):. doi: 10.1094/pdis-03-23-0478-re. [PMID: 37311227]
  • Jhonatan Barro, Emerson Medeiros Del Ponte, Tom Allen, Jason P Bond, Travis R Faske, Clayton Hollier, Yuba Raj Kandel, Daren S Mueller, Heather M Kelly, Nathan Michael Kleczewski, Keith A Ames, Paul Price, Edward Sikora, Carl Bradley. Efficacy and profitability of fungicides for managing frogeye leaf spot on soybean in the United States: A 10-year quantitative summary. Plant disease. 2023 May; ?(?):. doi: 10.1094/pdis-02-23-0291-re. [PMID: 37157104]
  • Seon Ae Jeong, Jisoo Song, Jiyeon Ham, Garam An, Gwonhwa Song, Whasun Lim. Tetraconazole interrupts mitochondrial function and intracellular calcium levels leading to apoptosis of bovine mammary epithelial cells. Pesticide biochemistry and physiology. 2023 Apr; 191(?):105366. doi: 10.1016/j.pestbp.2023.105366. [PMID: 36963936]
  • Edgar Humberto Nieto-López, Thomas J J Miorini, Cristian A Wulkop-Gil, Martin I Chilvers, Loren Giesler, Tamra A Jackson-Ziems, Mehdi Kabbage, Daren S Mueller, Damon L Smith, Juan Manuel Tovar-Pedraza, Jaime F Willbur, Sydney Everhart. Fungicide sensitivity of Sclerotinia sclerotiorum from U.S. soybean and dry bean, compared to different regions and climates. Plant disease. 2023 Jan; ?(?):. doi: 10.1094/pdis-07-22-1707-re. [PMID: 36691269]
  • Oksal Macar. Multiple toxic effects of tetraconazole in Allium cepa L. meristematic cells. Environmental science and pollution research international. 2021 Feb; 28(8):10092-10099. doi: 10.1007/s11356-020-11584-4. [PMID: 33169279]
  • Yanhua Wang, Yu Cheng Zhu, Wenhong Li. Interaction patterns and combined toxic effects of acetamiprid in combination with seven pesticides on honey bee (Apis mellifera L.). Ecotoxicology and environmental safety. 2020 Mar; 190(?):110100. doi: 10.1016/j.ecoenv.2019.110100. [PMID: 31869716]
  • Yanhua Wang, Yu Cheng Zhu, Wenhong Li. Comparative examination on synergistic toxicities of chlorpyrifos, acephate, or tetraconazole mixed with pyrethroid insecticides to honey bees (Apis mellifera L.). Environmental science and pollution research international. 2020 Mar; 27(7):6971-6980. doi: 10.1007/s11356-019-07214-3. [PMID: 31879892]
  • Shifeng Liu, Hongru Kou, Baofeng Mu, Jinzhong Wang, Zhiyong Zhang. Dietary risk evaluation of tetraconazole and bifenazate residues in fresh strawberry from protected field in North China. Regulatory toxicology and pharmacology : RTP. 2019 Aug; 106(?):1-6. doi: 10.1016/j.yrtph.2019.04.008. [PMID: 31009652]
  • Zhou Tong, Xu Dong, Shasha Yang, Mingna Sun, Tongchun Gao, Jinsheng Duan, Haiqun Cao. Enantioselective effects of the chiral fungicide tetraconazole in wheat: Fungicidal activity and degradation behavior. Environmental pollution (Barking, Essex : 1987). 2019 Apr; 247(?):1-8. doi: 10.1016/j.envpol.2019.01.013. [PMID: 30648617]
  • Melvin D Bolton, Malaika K Ebert, Luigi Faino, Viviana Rivera-Varas, Ronnie de Jonge, Yves Van de Peer, Bart P H J Thomma, Gary A Secor. RNA-sequencing of Cercospora beticola DMI-sensitive and -resistant isolates after treatment with tetraconazole identifies common and contrasting pathway induction. Fungal genetics and biology : FG & B. 2016 07; 92(?):1-13. doi: 10.1016/j.fgb.2016.04.003. [PMID: 27112724]
  • Wenwen Zhang, Jun Xu, Fengshou Dong, Xingang Liu, Ying Zhang, Xiaohu Wu, Yongquan Zheng. Effect of tetraconazole application on the soil microbial community. Environmental science and pollution research international. 2014; 21(13):8323-32. doi: 10.1007/s11356-014-2844-5. [PMID: 24705896]
  • Jing Li, Fengshou Dong, Jun Xu, Xingang Liu, Yuanbo Li, Weili Shan, Yongquan Zheng. Enantioselective determination of triazole fungice tetraconazole by chiral high-performance liquid chromatography and its application to pharmacokinetic study in cucumber, muskmelon, and soils. Chirality. 2012 Apr; 24(4):294-302. doi: 10.1002/chir.21997. [PMID: 22278951]
  • Melvin D Bolton, Keshav Birla, Viviana Rivera-Varas, Kurt D Rudolph, Gary A Secor. Characterization of CbCyp51 from field isolates of Cercospora beticola. Phytopathology. 2012 Mar; 102(3):298-305. doi: 10.1094/phyto-07-11-0212. [PMID: 22085297]
  • Yuanbo Li, Fengshou Dong, Xingang Liu, Jun Xu, Jing Li, Zhiqiang Kong, Xiu Chen, Xuyang Liang, Yongquan Zheng. Simultaneous enantioselective determination of triazole fungicides in soil and water by chiral liquid chromatography/tandem mass spectrometry. Journal of chromatography. A. 2012 Feb; 1224(?):51-60. doi: 10.1016/j.chroma.2011.12.044. [PMID: 22209355]
  • Adriano Aquino, Kaline A Wanderley, Carlos de Oliveira Paiva-Santos, Gilberto F de Sá, Marcelo da R Alexandre, Severino A Júnior, Sandro Navickiene. Coordination polymer adsorbent for matrix solid-phase dispersion extraction of pesticides during analysis of dehydrated Hyptis pectinata medicinal plant by GC/MS. Talanta. 2010 Dec; 83(2):631-6. doi: 10.1016/j.talanta.2010.10.014. [PMID: 21111184]
  • Anna Arnoldi, Sabrina Dallavalle, Lucio Merlini, Loana Musso, Gandolfina Farina, Maddalena Moretti, Lalith Jayasinghe. Synthesis and antifungal activity of a series of N-substituted [2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)]propylamines. Journal of agricultural and food chemistry. 2007 Oct; 55(20):8187-92. doi: 10.1021/jf071631g. [PMID: 17896810]
  • Mohamed M Amer, Mostafa A Shehata, Hayam M Lotfy, Hany H Monir. Determination of tetraconazole and diniconazole fungicide residues in tomatoes and green beans by capillary gas chromatography. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2007 Jun; 127(6):993-9. doi: 10.1248/yakushi.127.993. [PMID: 17541250]
  • Cristiane G Manzon, Anderson D Grützmacher, Fabrizio P Giolo, Crislaine A B Lima de Lima, Sandro D Nörnberg, Cristiane Müller, Wagner da R Härter. [Susceptibility of Trichogramma pretiosum Riley (Hymenoptera: Trichogrammatidae) adults to fungicides used to control apple diseases]. Neotropical entomology. 2006 Mar; 35(2):223-30. doi: 10.1590/s1519-566x2006000200011. [PMID: 17348134]
  • Olga Aguín, J Pedro Mansilla, María J Sainz. In vitro selection of an effective fungicide against Armillaria mellea and control of white root rot of grapevine in the field. Pest management science. 2006 Mar; 62(3):223-8. doi: 10.1002/ps.1149. [PMID: 16475239]
  • Alberto Angioni, Andrea Barra, Marco Arlorio, Jean Daniel Coisson, Maria T Russo, Filippo M Pirisi, Maurizio Satta, Paolo Cabras. Chemical composition, plant genetic differences, and antifungal activity of the essential oil of Helichrysum italicum G. Don ssp. microphyllum (Willd) Nym. Journal of agricultural and food chemistry. 2003 Feb; 51(4):1030-4. doi: 10.1021/jf025940c. [PMID: 12568568]
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