Cepharanthine (BioDeep_00000000222)

   

natural product PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


(14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2(16,19).1(3,10).1(21,25).0(4,8).0(14,39).0(31,35)]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene

化学式: C37H38N2O6 (606.273)
中文名称: 千金藤素, 千金藤碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 78.34%

分子结构信息

SMILES: CN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
InChI: InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1

描述信息

Cepharanthine is a bisbenzylisoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. It is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.
Cepharanthine is a natural product found in Stephania sinica, Stephania cephalantha, and other organisms with data available.
A bisbenzylisoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation.
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
D018501 - Antirheumatic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Origin: Plant; SubCategory_DNP: Isoquinoline alkaloids, Benzylisoquinoline alkaloids
Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50\\%) inhibitory concentration (IC50) and 90\\% inhibitory concentration (IC90) values of 1.90 and 4.46?μM[1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model[2][3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects[4][5][6][7][8].
Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50\%) inhibitory concentration (IC50) and 90\% inhibitory concentration (IC90) values of 1.90 and 4.46?μM[1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model[2][3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects[4][5][6][7][8].

同义名列表

28 个代谢物同义名

(14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2(16,19).1(3,10).1(21,25).0(4,8).0(14,39).0(31,35)]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene; (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene; (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2??,??.1?,??.1??,??.0?,?.0??,??.0??,??]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene; 22,33-Dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene; Oxyacanthan, 6,12-dimethoxy-2,2-dimethyl-6,7-(methylenebis(oxy))-; 6,12-dimethoxy-2,2-dimethyl-6,7-(methylenebis(oxy))oxyacanthan; 4-27-00-09061 (Beilstein Handbook Reference); Cepharanthine, >=98\\% (HPLC); Cepharanthine, >=95\\% (HPLC); 12-O-Methylcepharanoline; CEPHARANTHINE [WHO-DD]; O-Methylcepharanoline; Cepharanthine [JAN]; Cepharanthine (JAN); CEPHARANTHINE [MI]; Cepharanthine (TN); (+)-Cepharanthine; Spectrum3_001963; Spectrum2_000832; Cepharanthin,(S); Tox21_111483_1; Cepharanthine; cepharanthin; Tox21_111483; KBio3_002909; Cepharantin; 1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2,3:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-,(14aS,26aR)-; Cepharanthine



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ABCB1, ACE2, ANXA5, BCL2, CASP3, MAPK14, MAPK8, MTOR, NFKB1, NLRP3, PIK3CA, PLA2G12A, PTGS2, STAT3
Peripheral membrane protein 3 ANXA5, MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 9 BCL2, CASP3, HMOX1, MAPK14, MAPK8, MTOR, NFKB1, NLRP3, STAT3
cytosol 11 ANXA5, BCL2, CASP3, HMOX1, MAPK14, MAPK8, MTOR, NFKB1, NLRP3, PIK3CA, STAT3
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 7 CASP3, HMOX1, MAPK14, MAPK8, MTOR, NFKB1, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 4 ABCB1, ABCC10, ACE2, TNF
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 1 PIK3CA
Multi-pass membrane protein 2 ABCB1, ABCC10
Golgi apparatus membrane 2 MTOR, NLRP3
Synapse 1 MAPK8
cell surface 3 ABCB1, ACE2, TNF
glutamatergic synapse 2 CASP3, MAPK14
Golgi membrane 2 MTOR, NLRP3
lysosomal membrane 2 ABCC10, MTOR
neuronal cell body 2 CASP3, TNF
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 NLRP3
Lysosome 1 MTOR
plasma membrane 7 ABCB1, ABCC10, ACE2, IFNLR1, PIK3CA, STAT3, TNF
Membrane 9 ABCB1, ABCC10, ACE2, ANXA5, BCL2, HMOX1, IFNLR1, MTOR, NLRP3
apical plasma membrane 2 ABCB1, ACE2
axon 1 MAPK8
basolateral plasma membrane 1 ABCC10
caveola 1 PTGS2
extracellular exosome 3 ABCB1, ACE2, ANXA5
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, HMOX1, NLRP3, PTGS2
extracellular space 5 ACE2, CXCL8, HMOX1, IL6, TNF
perinuclear region of cytoplasm 2 HMOX1, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, MAPK14, NFKB1, NLRP3
protein-containing complex 2 BCL2, PTGS2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 ACE2, IFNLR1
Secreted 5 ACE2, CXCL8, IL6, NLRP3, PLA2G12A
extracellular region 9 ACE2, ANXA5, CXCL8, IL6, MAPK14, NFKB1, NLRP3, PLA2G12A, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
transcription regulator complex 2 NFKB1, STAT3
Cell projection, cilium 1 ACE2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, TNF
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 2 ABCB1, ACE2
Membrane raft 2 ACE2, TNF
pore complex 1 BCL2
focal adhesion 1 ANXA5
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
cilium 1 ACE2
chromatin 2 NFKB1, STAT3
phagocytic cup 1 TNF
brush border membrane 1 ACE2
spindle pole 1 MAPK14
Basolateral cell membrane 1 ABCC10
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, NLRP3
microtubule organizing center 1 NLRP3
myelin sheath 1 BCL2
basal plasma membrane 1 ABCC10
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 MAPK14, NFKB1
endoplasmic reticulum lumen 3 ACE2, IL6, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 NFKB1
endocytic vesicle membrane 1 ACE2
Single-pass type IV membrane protein 1 HMOX1
vesicle membrane 1 ANXA5
Basal cell membrane 1 ABCC10
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2


文献列表

  • Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Jinwen Min, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Cepharanthine synergistically promotes methylprednisolone pharmacodynamics against human peripheral blood mononuclear cells possibly via regulation of P-glycoprotein/glucocorticoid receptor translocation. BMC complementary medicine and therapies. 2024 May; 24(1):186. doi: 10.1186/s12906-024-04489-z. [PMID: 38734604]
  • Jiangping Yang, Liujie Qin, Shouchang Zhou, Jixing Li, Yu Tu, Minfeng Mo, Xuenian Liu, Jinglun Huang, Xiumei Qin, Aijun Jiao, Wei Wei, Peilin Yang. Network pharmacology, molecular docking and experimental study of CEP in nasopharyngeal carcinoma. Journal of ethnopharmacology. 2024 Apr; 323(?):117667. doi: 10.1016/j.jep.2023.117667. [PMID: 38159821]
  • Zhuo Liu, Shaoqin Shen, Yujie Wang, Shuqi Sun, Tong Yu, Yanhong Fu, Rong Zhou, Chunjin Li, Rui Cao, Yanshu Zhang, Nan Li, Liangdan Sun, Xiaoming Song. The genome of Stephania japonica provides insights into the biosynthesis of cepharanthine. Cell reports. 2024 Mar; 43(3):113832. doi: 10.1016/j.celrep.2024.113832. [PMID: 38381605]
  • Yunfang Yang, Changjiang Li, Sijin Yang, Zhuo Zhang, Xue Bai, Hongmei Tang, Jiang Huang. Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway. Aging. 2024 Mar; 16(7):5905-5915. doi: 10.18632/aging.205678. [PMID: 38517394]
  • Liang Leng, Zhichao Xu, Bixia Hong, Binbin Zhao, Ya Tian, Can Wang, Lulu Yang, Zhongmei Zou, Lingyu Li, Ke Liu, Wanjun Peng, Jiangning Liu, Zhoujie An, Yalin Wang, Baozhong Duan, Zhigang Hu, Chuan Zheng, Sanyin Zhang, Xiaodong Li, Maochen Li, Zhaoyu Liu, Zenghao Bi, Tianxing He, Baimei Liu, Huahao Fan, Chi Song, Yigang Tong, Shilin Chen. Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery. Nature communications. 2024 Feb; 15(1):1537. doi: 10.1038/s41467-024-45690-5. [PMID: 38378731]
  • Yichao Liang, Jun Li, Honglin Xu, Mingjie Pang, Changlei Hu, Xie Weng, Wei Xie. Cepharanthine suppresses proliferation and metastasis and enhances apoptosis by regulating JAK2/Stat3 pathway in hepatocellular carcinoma. Cellular and molecular biology (Noisy-le-Grand, France). 2023 Dec; 69(14):94-100. doi: 10.14715/cmb/2023.69.14.15. [PMID: 38279472]
  • Jun Chen, Cheng Lei Xia, Rui Dong, Xian Guo Liu, Jing Xia. Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway. Discovery medicine. 2023 Oct; 35(178):777-786. doi: 10.24976/discov.med.202335178.72. [PMID: 37811615]
  • YingZheng Wang, Tong Wang, HuaXin Wang, WeiDong Liu, Xiao Li, XiaoYan Wang, YaNan Zhang. A mechanistic updated overview on Cepharanthine as potential anticancer agent. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 165(?):115107. doi: 10.1016/j.biopha.2023.115107. [PMID: 37423171]
  • Ke Liu, Bixia Hong, Shuqi Wang, Fuxing Lou, Yecheng You, Ruolan Hu, Amna Shafqat, Huahao Fan, Yigang Tong. Pharmacological Activity of Cepharanthine. Molecules (Basel, Switzerland). 2023 Jun; 28(13):. doi: 10.3390/molecules28135019. [PMID: 37446681]
  • Liangliang Shi, Shuaizhe Wang, Shangzu Zhang, Jiawei Wang, Yaping Chen, Yangyang Li, Zhiwei Liu, Sichen Zhao, Benjun Wei, Liying Zhang. Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Jun; ?(?):. doi: 10.1007/s00210-023-02537-y. [PMID: 37338575]
  • Aswad Khadilkar, Zoie L Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M Oda, Warren S Vidar, Trevor N Clark, Preston K Manwill, Daniel A Todd, Sarah A Barr, Lauren K Olinger, Susan L Fink, Wendy K Strangman, Roger G Linington, John B MacMillan, Nadja B Cech, Stephen J Polyak. Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents. Journal of natural products. 2023 Apr; 86(4):1061-1073. doi: 10.1021/acs.jnatprod.3c00159. [PMID: 37043739]
  • Di Liang, Qi Li, Lina Du, Guifang Dou. Pharmacological Effects and Clinical Prospects of Cepharanthine. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248933. [PMID: 36558061]
  • Xiang-Yan Wei, Jian-Dong Long, Jing-Rui Chai, Jing Chen, Jian-Ping Gao, Yu-Jun Wang, Jing-Gen Liu. Antinociceptive activities and mechanism of action of Cepharanthine. Biochemical and biophysical research communications. 2022 07; 614(?):219-224. doi: 10.1016/j.bbrc.2022.04.083. [PMID: 35636221]
  • H Fan, K Liu, B Hong, S He, P Han, M Li, S Wang, Y Tong. [Progress in the study of antiviral activity of cepharanthine against SARS-CoV-2]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2022 Jun; 42(6):955-956. doi: 10.12122/j.issn.1673-4254.2022.06.22. [PMID: 35790449]
  • Jian Li, Guangrui Chen, Zhiyun Meng, Zhuona Wu, Hui Gan, Xiaoxia Zhu, Peng Han, Taoyun Liu, Fanjun Wang, Ruolan Gu, Guifang Dou. Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092745. [PMID: 35566097]
  • Atsushi Hijikata, Clara Shionyu-Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Takatsugu Hirokawa, Shogo Nakajima, Koichi Watashi, Tsuyoshi Shirai. Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2. FEBS open bio. 2022 01; 12(1):285-294. doi: 10.1002/2211-5463.13337. [PMID: 34850606]
  • Shiqi Gao, Liuzhi Zhou, Jianan Lu, Yuanjian Fang, Haijian Wu, Weilin Xu, Yuanbo Pan, Junjie Wang, Xiaoyu Wang, Jianmin Zhang, Anwen Shao. Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15-Lipoxygenase-1-Mediated Microglia and Endothelial Cell Ferroptosis. Oxidative medicine and cellular longevity. 2022; 2022(?):4295208. doi: 10.1155/2022/4295208. [PMID: 35186185]
  • Caihong Lu, Jinpeng Zheng, Yaning Ding, Yuanyuan Meng, Fangyun Tan, Wei Gong, Xiaoyang Chu, Xiaolong Kong, Chunsheng Gao. Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy. Drug delivery. 2021 Dec; 28(1):2582-2593. doi: 10.1080/10717544.2021.2009936. [PMID: 34866533]
  • Xuan Zhang, Gaohua Zhang, Zhijun Zhao, Ruilian Xiu, Jie Jia, Pingping Chen, Yanshuang Liu, Yuanyuan Wang, Jianfeng Yi. Cepharanthine, a novel selective ANO1 inhibitor with potential for lung adenocarcinoma therapy. Biochimica et biophysica acta. Molecular cell research. 2021 11; 1868(12):119132. doi: 10.1016/j.bbamcr.2021.119132. [PMID: 34450215]
  • Pan Gao, Zhujun Jiang, Qiao Luo, Chengqiao Mu, Mengsuo Cui, Xinggang Yang. Preparation and Evaluation of Self-emulsifying Drug Delivery System (SEDDS) of Cepharanthine. AAPS PharmSciTech. 2021 Oct; 22(7):245. doi: 10.1208/s12249-021-02085-9. [PMID: 34611770]
  • Yao Liu, Qiong Tang, Zhili Rao, Yang Fang, Xinni Jiang, Wenjun Liu, Fei Luan, Nan Zeng. Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway. Antiviral research. 2021 09; 193(?):105143. doi: 10.1016/j.antiviral.2021.105143. [PMID: 34303748]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Hongyan Ma, Huiyun Liang, Shengxin Cai, Barry R O'Keefe, Susan L Mooberry, Robert H Cichewicz. An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures. Journal of natural products. 2021 03; 84(3):750-761. doi: 10.1021/acs.jnatprod.0c00946. [PMID: 33226219]
  • Shasha Li, Wenli Liu, Yangzhen Chen, Liqin Wang, Wenlin An, Xiaoping An, Lihua Song, Yigang Tong, Huahao Fan, Chenyang Lu. Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus. Briefings in bioinformatics. 2021 03; 22(2):1378-1386. doi: 10.1093/bib/bbaa387. [PMID: 33423067]
  • Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Molecular mechanisms and therapeutic implications of tetrandrine and cepharanthine in T cell acute lymphoblastic leukemia and autoimmune diseases. Pharmacology & therapeutics. 2021 01; 217(?):107659. doi: 10.1016/j.pharmthera.2020.107659. [PMID: 32800789]
  • Moshe Rogosnitzky, Paul Okediji, Igor Koman. Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19. Pharmacological reports : PR. 2020 Dec; 72(6):1509-1516. doi: 10.1007/s43440-020-00132-z. [PMID: 32700247]
  • Xunge Zhang, Ping Feng, Xinfu Gao, Bin Wang, Chunxia Gou, Ruimin Bian. In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes. Pharmaceutical biology. 2020 Dec; 58(1):247-252. doi: 10.1080/13880209.2020.1741650. [PMID: 32223485]
  • Yinlan Xu, Jiangang Zheng, Panpan Sun, Jianhua Guo, Xiaozhong Zheng, Yaogui Sun, Kuohai Fan, Wei Yin, Hongquan Li, Na Sun. Cepharanthine and Curcumin inhibited mitochondrial apoptosis induced by PCV2. BMC veterinary research. 2020 Sep; 16(1):345. doi: 10.1186/s12917-020-02568-0. [PMID: 32948186]
  • Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Hongguang Wu, Haruki Yamada, Toshihiko Hirano. Bisbenzylisoquinoline alkaloids and P-glycoprotein function: A structure activity relationship study. Bioorganic & medicinal chemistry. 2020 06; 28(12):115553. doi: 10.1016/j.bmc.2020.115553. [PMID: 32503690]
  • Rami A Ballout, Dmitri Sviridov, Michael I Bukrinsky, Alan T Remaley. The lysosome: A potential juncture between SARS-CoV-2 infectivity and Niemann-Pick disease type C, with therapeutic implications. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 06; 34(6):7253-7264. doi: 10.1096/fj.202000654r. [PMID: 32367579]
  • Hua-Hao Fan, Li-Qin Wang, Wen-Li Liu, Xiao-Ping An, Zhen-Dong Liu, Xiao-Qi He, Li-Hua Song, Yi-Gang Tong. Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model. Chinese medical journal. 2020 May; 133(9):1051-1056. doi: 10.1097/cm9.0000000000000797. [PMID: 32149769]
  • Dong Eon Kim, Jung Sun Min, Min Seong Jang, Jun Young Lee, Young Sup Shin, Jong Hwan Song, Hyoung Rae Kim, Seungtaek Kim, Young-Hee Jin, Sunoh Kwon. Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells. Biomolecules. 2019 11; 9(11):. doi: 10.3390/biom9110696. [PMID: 31690059]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Christian Bailly. Cepharanthine: An update of its mode of action, pharmacological properties and medical applications. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Sep; 62(?):152956. doi: 10.1016/j.phymed.2019.152956. [PMID: 31132753]
  • Wencheng Xu, Xiaoqin Wang, Yuanchao Tu, Hiroshi Masaki, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells. Chemico-biological interactions. 2019 Sep; 310(?):108726. doi: 10.1016/j.cbi.2019.108726. [PMID: 31255635]
  • Sk Abrar Shahriyar, Seon Min Woo, Seung Un Seo, Kyoung-Jin Min, Taeg Kyu Kwon. Cepharanthine Enhances TRAIL-Mediated Apoptosis Through STAMBPL1-Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells. International journal of molecular sciences. 2018 Oct; 19(10):. doi: 10.3390/ijms19103280. [PMID: 30360403]
  • Keiko Aota, Tomoko Yamanoi, Koichi Kani, Masayuki Azuma. Cepharanthine Inhibits IFN-γ-Induced CXCL10 by Suppressing the JAK2/STAT1 Signal Pathway in Human Salivary Gland Ductal Cells. Inflammation. 2018 Feb; 41(1):50-58. doi: 10.1007/s10753-017-0662-x. [PMID: 28879548]
  • Yingbin Deng, Weijun Wu, Sunzhi Ye, Wei Wang, Zhiyi Wang. Determination of cepharanthine in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Pharmaceutical biology. 2017 Dec; 55(1):1775-1779. doi: 10.1080/13880209.2017.1328446. [PMID: 28521597]
  • Keshav Raj Paudel, Rajendra Karki, Dong-Wook Kim. Cepharanthine inhibits in vitro VSMC proliferation and migration and vascular inflammatory responses mediated by RAW264.7. Toxicology in vitro : an international journal published in association with BIBRA. 2016 Aug; 34(?):16-25. doi: 10.1016/j.tiv.2016.03.010. [PMID: 27021874]
  • Yara A Samra, Heba S Said, Nehal M Elsherbiny, Gregory I Liou, Mamdouh M El-Shishtawy, Laila A Eissa. Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome. Life sciences. 2016 Jul; 157(?):187-199. doi: 10.1016/j.lfs.2016.06.002. [PMID: 27266851]
  • Tomofumi Uto, Masaaki Toyama, Keisuke Yoshinaga, Masanori Baba. Cepharanthine induces apoptosis through the mitochondria/caspase pathway in murine dendritic cells. Immunopharmacology and immunotoxicology. 2016 Jun; 38(3):238-43. doi: 10.3109/08923973.2016.1173059. [PMID: 27121492]
  • Yin-Kuang Chang, Su-Cheng Huang, Ming-Chang Kao, Chun-Jen Huang. Cepharanthine alleviates liver injury in a rodent model of limb ischemia-reperfusion. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists. 2016 Mar; 54(1):11-5. doi: 10.1016/j.aat.2015.11.004. [PMID: 26711228]
  • Ming-Chang Kao, Chen-Hsien Yang, Wei-Chih Chou, Joen-Rong Sheu, Chun-Jen Huang. Cepharanthine mitigates lung injury in lower limb ischemia-reperfusion. The Journal of surgical research. 2015 Dec; 199(2):647-56. doi: 10.1016/j.jss.2015.06.041. [PMID: 26193830]
  • Peiyan Hua, Mei Sun, Guangxin Zhang, Yifan Zhang, Xin Tian, Xin Li, Ranji Cui, Xingyi Zhang. Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells. Biochemical and biophysical research communications. 2015 May; 460(2):136-42. doi: 10.1016/j.bbrc.2015.02.131. [PMID: 25747710]
  • Camille Desgrouas, Charles Chapus, Jérôme Desplans, Christelle Travaille, Aurélie Pascual, Béatrice Baghdikian, Evelyne Ollivier, Daniel Parzy, Nicolas Taudon. In vitro antiplasmodial activity of cepharanthine. Malaria journal. 2014 Aug; 13(?):327. doi: 10.1186/1475-2875-13-327. [PMID: 25145413]
  • Zhengjun Cheng, Rong Liu, Xiaohui Jiang, Qianyong Xu. The interaction between cepharanthine and two serum albumins: multiple spectroscopic and chemometric investigations. Luminescence : the journal of biological and chemical luminescence. 2014 Aug; 29(5):504-15. doi: 10.1002/bio.2576. [PMID: 24123839]
  • Kouki Matsuda, Shinichiro Hattori, Yuji Komizu, Ryusho Kariya, Ryuichi Ueoka, Seiji Okada. Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity. Bioorganic & medicinal chemistry letters. 2014 May; 24(9):2115-7. doi: 10.1016/j.bmcl.2014.03.041. [PMID: 24704028]
  • Camille Desgrouas, Jérôme Dormoi, Charles Chapus, Evelyne Ollivier, Daniel Parzy, Nicolas Taudon. In vitro and in vivo combination of cepharanthine with anti-malarial drugs. Malaria journal. 2014 Mar; 13(?):90. doi: 10.1186/1475-2875-13-90. [PMID: 24618129]
  • Hailong Huang, Guixue Hu, Chunfeng Wang, Hao Xu, Xiaoqing Chen, Aidong Qian. Cepharanthine, an alkaloid from Stephania cepharantha Hayata, inhibits the inflammatory response in the RAW264.7 cell and mouse models. Inflammation. 2014 Feb; 37(1):235-46. doi: 10.1007/s10753-013-9734-8. [PMID: 24045962]
  • Shigeki Inui, Satoshi Itami. Induction of insulin-like growth factor-I by cepharanthine from dermal papilla cells: a novel potential pathway for hair growth stimulation. The Journal of dermatology. 2013 Dec; 40(12):1054-5. doi: 10.1111/1346-8138.12269. [PMID: 24164396]
  • Jun-Jiang Lv, Min Xu, Dong Wang, Hong-Tao Zhu, Chong-Ren Yang, Yi-Fei Wang, Yan Li, Ying-Jun Zhang. Cytotoxic bisbenzylisoquinoline alkaloids from Stephania epigaea. Journal of natural products. 2013 May; 76(5):926-32. doi: 10.1021/np400084t. [PMID: 23621840]
  • Norio Sogawa, Kanji Hirai, Chiharu Sogawa, Kazumi Ohyama, Ikuko Miyazaki, Goichi Tsukamoto, Masato Asanuma, Akira Sasaki, Shigeo Kitayama. Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression. Life sciences. 2013 Apr; 92(12):727-32. doi: 10.1016/j.lfs.2013.01.031. [PMID: 23399700]
  • Sothavireak Bory, Sok-Siya Bun, Béatrice Baghdikian, Aurélien Dumètre, Sébastien Hutter, Fathi Mabrouki, Hot Bun, Riad Elias, Nadine Azas, Evelyne Ollivier. HPLC analysis of Stephania rotunda extracts and correlation with antiplasmodial activity. Phytotherapy research : PTR. 2013 Feb; 27(2):278-84. doi: 10.1002/ptr.4710. [PMID: 22566106]
  • Paul Klausmeyer, Thomas G McCloud, Dominic A Scudiero, Michael J Currens, John H Cardellina Ii, Robert H Shoemaker. Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα. Bioorganic & medicinal chemistry. 2012 Aug; 20(15):4646-52. doi: 10.1016/j.bmc.2012.06.017. [PMID: 22766217]
  • Rie Tabata, Chiharu Tabata, Ayako Tazoh, Tomoko Nagai. Low dose cepharanthine ameliorates immune thrombocytopenic purpura associated with multiple myeloma. International immunopharmacology. 2012 Jul; 13(3):242-4. doi: 10.1016/j.intimp.2012.04.015. [PMID: 22561120]
  • Nader Pazyar, Noorodin Jamshydian. Cepharanthine: a therapeutic potential candidate for psoriasis. Journal of alternative and complementary medicine (New York, N.Y.). 2012 Jul; 18(7):639-40. doi: 10.1089/acm.2012.0314. [PMID: 22747436]
  • Yu-Bing Zhou, Ya-Feng Wang, Yan Zhang, Li-Yun Zheng, Xiao-Ang Yang, Ning Wang, Jin-Hua Jiang, Fang Ma, De-Tao Yin, Chang-Yu Sun, Qing-Duan Wang. In vitro activity of cepharanthine hydrochloride against clinical wild-type and lamivudine-resistant hepatitis B virus isolates. European journal of pharmacology. 2012 May; 683(1-3):10-5. doi: 10.1016/j.ejphar.2012.02.030. [PMID: 22387093]
  • Neill J Liptrott, Sudeep Pushpakom, Christoph Wyen, Gerd Fätkenheuer, Christian Hoffmann, Stefan Mauss, Heribert Knechten, Norbert H Brockmeyer, Elizabeth Hopper-Borge, Marco Siccardi, David J Back, Saye H Khoo, Munir Pirmohamed, Andrew Owen. Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS. Pharmacogenetics and genomics. 2012 Jan; 22(1):10-9. doi: 10.1097/fpc.0b013e32834dd82e. [PMID: 22082652]
  • Junya Kusaka, Satoshi Hagiwara, Akira Hasegawa, Kyosuke Kudo, Hironori Koga, Takayuki Noguchi. Cepharanthine improves renal ischemia-reperfusion injury in rats. The Journal of surgical research. 2011 Nov; 171(1):212-7. doi: 10.1016/j.jss.2010.01.025. [PMID: 20421112]
  • Kyosuke Kudo, Satoshi Hagiwara, Akira Hasegawa, Junya Kusaka, Hironori Koga, Takayuki Noguchi. Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation. The Journal of surgical research. 2011 Nov; 171(1):199-204. doi: 10.1016/j.jss.2010.01.007. [PMID: 20334881]
  • Payam Zahedi, Raquel De Souza, Loan Huynh, Micheline Piquette-Miller, Christine Allen. Combination drug delivery strategy for the treatment of multidrug resistant ovarian cancer. Molecular pharmaceutics. 2011 Feb; 8(1):260-9. doi: 10.1021/mp100323z. [PMID: 21166459]
  • Moshe Rogosnitzky, Rachel Danks. Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions. Pharmacological reports : PR. 2011; 63(2):337-47. doi: 10.1016/s1734-1140(11)70500-x. [PMID: 21602589]
  • Guangtao Hao, Haixia Liang, Yuanyuan Li, Haiyan Li, Hongzhi Gao, Guang Liu, Zeyuan Liu. Simple, sensitive and rapid HPLC-MS/MS method for the determination of cepharanthine in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Oct; 878(28):2923-7. doi: 10.1016/j.jchromb.2010.08.026. [PMID: 20846916]
  • Sothavireak Bory, Sok-Siya Bun, Béatrice Baghdikian, Fathi Mabrouki, Sun Kaing Cheng, Riad Elias, Hot Bune, Evelyne Ollivier. Simultaneous HPLC determination of three bioactive alkaloids in the Asian medicinal plant Stephania rotunda. Natural product communications. 2010 Jun; 5(6):877-82. doi: . [PMID: 20614814]
  • Ilhami Gülçin, Riad Elias, Akçahan Gepdiremen, Aun Chea, Fevzi Topal. Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline. Journal of enzyme inhibition and medicinal chemistry. 2010 Feb; 25(1):44-53. doi: 10.3109/14756360902932792. [PMID: 20030508]
  • Kirandeep Kaur, Meenakshi Jain, Tarandeep Kaur, Rahul Jain. Antimalarials from nature. Bioorganic & medicinal chemistry. 2009 May; 17(9):3229-56. doi: 10.1016/j.bmc.2009.02.050. [PMID: 19299148]
  • Dorota Halicka, Masamichi Ita, Toshiki Tanaka, Akira Kurose, Zbigniew Darzynkiewicz. Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage. Pharmacological reports : PR. 2008 Jan; 60(1):93-100. doi: ". [PMID: 18276990]
  • Ryuji Ikeda, Xiao-Fang Che, Tatsuya Yamaguchi, Mina Ushiyama, Chun-Lei Zheng, Hiroshi Okumura, Yasuo Takeda, Yoshihiko Shibayama, Kazuo Nakamura, Hei-Cheul Jeung, Tatsuhiko Furukawa, Tomoyuki Sumizawa, Misako Haraguchi, Shin-ichi Akiyama, Katsushi Yamada. Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer science. 2005 Jun; 96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x. [PMID: 15958061]
  • Pamela A Tamez, Dan Lantvit, Eulenia Lim, John M Pezzuto. Chemosensitizing action of cepharanthine against drug-resistant human malaria, Plasmodium falciparum. Journal of ethnopharmacology. 2005 Apr; 98(1-2):137-42. doi: 10.1016/j.jep.2005.01.015. [PMID: 15763374]
  • Yu-cheng Song, Wei Xia, Jin-hua Jiang, Qing-duan Wang. [Reversal of multidrug resistance in drug-resistant cell line EAC/ADR by cepharanthine hydrochloride and its mechanism]. Yao xue xue bao = Acta pharmaceutica Sinica. 2005 Mar; 40(3):204-7. doi: ". [PMID: 15952589]
  • Akio Nakajima, Yuzo Yamamoto, Kojiro Taura, Koichiro Hata, Manabu Fukumoto, Hiroshi Uchinami, Kei Yonezawa, Yoshio Yamaoka. Beneficial effect of cepharanthine on overcoming drug-resistance of hepatocellular carcinoma. International journal of oncology. 2004 Mar; 24(3):635-45. doi: . [PMID: 14767548]
  • Kentaro Kogure, Koichiro Tsuchiya, Kazutoyo Abe, Michinori Akasu, Toshiaki Tamaki, Kenji Fukuzawa, Hiroshi Terada. Direct radical scavenging by the bisbenzylisoquinoline alkaloid cepharanthine. Biochimica et biophysica acta. 2003 Jun; 1622(1):1-5. doi: 10.1016/s0304-4165(03)00095-3. [PMID: 12829254]
  • Makoto Nagano, Tomoko Kanno, Hirofumi Fujita, Shikibu Muranaka, Takuzo Fujiwara, Kozo Utsumi. Cepharanthine, an anti-inflammatory drug, suppresses mitochondrial membrane permeability transition. Physiological chemistry and physics and medical NMR. 2003; 35(2):131-43. doi: ". [PMID: 15552724]
  • M Baba, M Okamoto, N Kashiwaba, M Ono. Anti-HIV-1 activity and structure-activity relationship of cepharanoline derivatives in chronically infected cells. Antiviral chemistry & chemotherapy. 2001 Sep; 12(5):307-12. doi: 10.1177/095632020101200506. [PMID: 11900350]
  • T Sato, I Morita, H Fujita, M Ono, A Kimishima, J Tomiyama, S Murota. Pharmacological characterization of cepharanthin in chronic idiopathic thrombocytopenic purpura. Platelets. 2001 May; 12(3):156-62. doi: 10.1080/09537100120039334. [PMID: 11304417]
  • T Ebina, M Ono. [Antitumor effect of the plant alkaloid preparation, cepharanthin]. Gan to kagaku ryoho. Cancer & chemotherapy. 2001 Feb; 28(2):211-5. doi: . [PMID: 11242648]
  • H Maruyama, S Kikuchi, K Kawaguchi, R Hasunuma, M Ono, M Ohbu, Y Kumazawa. Suppression of lethal toxicity of endotoxin by biscoclaurine alkaloid cepharanthin. Shock (Augusta, Ga.). 2000 Feb; 13(2):160-5. doi: 10.1097/00024382-200013020-00011. [PMID: 10670847]
  • K Murakami, K Okajima, M Uchiba. The prevention of lipopolysaccharide-induced pulmonary vascular injury by pretreatment with cepharanthine in rats. American journal of respiratory and critical care medicine. 2000 Jan; 161(1):57-63. doi: 10.1164/ajrccm.161.1.9808142. [PMID: 10619798]
  • K Kogure, S Goto, K Abe, C Ohiwa, M Akasu, H Terada. Potent antiperoxidation activity of the bisbenzylisoquinoline alkaloid cepharanthine: the amine moiety is responsible for its pH-dependent radical scavenge activity. Biochimica et biophysica acta. 1999 Jan; 1426(1):133-42. doi: 10.1016/s0304-4165(98)00146-9. [PMID: 9878710]
  • K Nishikawa, J Asaumi, S Kawasaki, M Kuroda, Y Takeda, Y Hiraki. Influence of cepharanthin on the intracellular accumulation of adriamycin in normal liver cells and spleen cells of mice in vitro and in vivo. Anticancer research. 1997 Sep; 17(5A):3617-21. doi: NULL. [PMID: 9413213]
  • K Aogi, M Nishiyama, R Kim, N Hirabayashi, T Toge, A Mizutani, K Okada, H Sumiyoshi, Y Fujiwara, M Yamakido, T Kusano, T Andoh. Overcoming CPT-11 resistance by using a biscoclaurine alkaloid, cepharanthine, to modulate plasma trans-membrane potential. International journal of cancer. 1997 Jul; 72(2):295-300. doi: 10.1002/(sici)1097-0215(19970717)72:2<295::aid-ijc16>3.0.co;2-f. [PMID: 9219836]
  • Y Shichiri, T Kanba, S Yoshida, Y Arai, Y Kakehi, O Yoshida. Intra-arterial infusion chemotherapy in combination with a biscoclaurine alkaloid, Cepharanthin, to treat bone metastasis arising from renal cell carcinoma. International journal of urology : official journal of the Japanese Urological Association. 1994 Dec; 1(4):349-51. doi: 10.1111/j.1442-2042.1994.tb00063.x. [PMID: 7614400]
  • R Makidono, Y Makidono. [Hematopoietic and lymphoid cell recovery from radiation damage by cytokines]. Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica. 1994 Nov; 54(13):1294-305. doi: ". [PMID: 7610033]
  • Y Kakehi, O Yoshida, T Segawa, A Kanematsu, M Hiura, Y Shichiri, Y Arai. [Intraarterial chemotherapy for metastatic renal cell carcinomas: combination with MDR-overcoming agents]. Hinyokika kiyo. Acta urologica Japonica. 1994 Oct; 40(10):925-9. doi: . [PMID: 7992710]
  • T Fujii. [Phospholipid dynamics and function in cell membrane of blood cells. With reference to mode of action of certain amphiphilic drugs]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1994 Jun; 114(6):374-87. doi: 10.1248/yakushi1947.114.6_374. [PMID: 8051627]
  • S Nomura, M Yanabu, T Miyake, Y Miyazaki, T Kawakatsu, H Kido, K Yamaguchi, T Fukuroi, H Kagawa, M Suzuki. Effect of cepharanthin and cytochalasin D on platelet internalization of anti-glycoprotein IIb/IIIa antibodies. Autoimmunity. 1994; 18(1):23-9. doi: 10.3109/08916939409014676. [PMID: 7999953]
  • Y Kakehi, T Hashimura, O Yoshida, T Segawa, A Kanematsu. [Circumvention of the multidrug-resistance in renal cancer by bisbenzylisoquinoline]. Hinyokika kiyo. Acta urologica Japonica. 1993 Dec; 39(12):1227-32. doi: . [PMID: 8285174]
  • Y Kakehi, T Segawa, T Hashimura, O Yoshida. [Circumvention of the intrinsic multidrug-resistance in renal cell carcinoma]. Hinyokika kiyo. Acta urologica Japonica. 1992 Nov; 38(11):1319-24. doi: NULL. [PMID: 1485588]
  • S Akiba, E Kato, T Sato, T Fujii. Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells. Biochemical pharmacology. 1992 Jul; 44(1):45-50. doi: 10.1016/0006-2952(92)90036-i. [PMID: 1632837]
  • K Morikawa, F Oseko, S Morikawa. Inhibition of proliferation and differentiation of human B-lymphocytes by a biscoclaurine alkaloid. International journal of immunopharmacology. 1992 Jul; 14(5):941-9. doi: 10.1016/0192-0561(92)90094-2. [PMID: 1387392]
  • M Nishiyama, K Aogi, S Saeki, R Kim, K Kuroi, Y Yamaguchi, T Toge. A role for plasma membrane potential in doxorubicin--induced cytotoxicity. Anticancer research. 1992 May; 12(3):849-52. doi: NULL. [PMID: 1622144]
  • R Makidono, T Ouchida, A Makidono, K Jingu. [Severe damage of CD4-2H4+ T subpopulation cells (naive T cells and suppressor/inducer) by radiation therapy, their recovery being promoted by a plant alkaloid]. Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica. 1992 Feb; 52(2):223-8. doi: . [PMID: 1561062]
  • N Homma, F Gejyo, M Arakawa. [Prevention and therapy of dialysis amyloidosis]. Nihon rinsho. Japanese journal of clinical medicine. 1992 Jan; 50 Suppl(?):817-23. doi: NULL. [PMID: 1578773]
  • M Nishiyama, K Aogi, S Saeki, N Hirabayashi, T Toge. [Combination of a biscoclaurine alkaloid, cepharanthine, and anticancer agents: effects and mechanism in human gastric and pancreatic carcinoma cell lines]. Gan to kagaku ryoho. Cancer & chemotherapy. 1991 Nov; 18(14):2429-33. doi: . [PMID: 1952962]
  • T Ebina, K Murata. [Antitumor Effector mechanism of plant alkaloid preparation, cepharanthin, by intratumoral administration]. Gan to kagaku ryoho. Cancer & chemotherapy. 1991 Aug; 18(11):1812-6. doi: . [PMID: 1877822]
  • H Ito, H Ito, H Amano, H Noda. Inhibitory effect of a biscoclaurine alkaloid, cepharanthin, on lung metastasis of Lewis lung carcinoma. Japanese journal of pharmacology. 1991 Jun; 56(2):195-202. doi: 10.1254/jjp.56.195. [PMID: 1880998]
  • K Edashige, T Utsumi, K Utsumi. Inhibition of 12-O-tetradecanoyl phorbol-13-acetate promoted tumorigenesis by cepharanthine, a biscoclaurine alkaloid, in relation to the inhibitory effect on protein kinase C. Biochemical pharmacology. 1991 Jan; 41(1):71-8. doi: 10.1016/0006-2952(91)90012-t. [PMID: 1986745]
  • T Matsuno, K Orita, K Edashige, H Kobuchi, E F Sato, B Inouye, M Inoue, K Utsumi. Inhibition of active oxygen generation in guinea-pig neutrophils by biscoclaurine alkaloids. Biochemical pharmacology. 1990 Apr; 39(7):1255-9. doi: 10.1016/0006-2952(90)90271-l. [PMID: 2157445]
  • K Shinoda, I Adachi, M Ueno, I Horikoshi. [Effects of cepharanthine on liposomal permeability and size]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1990 Mar; 110(3):186-90. doi: 10.1248/yakushi1947.110.3_186. [PMID: 2374091]