Cepharanthine (BioDeep_00000000222)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

化学式: C37H38N2O6 (606.2729727999999)
中文名称: 千金藤素, 千金藤碱, 千金藤素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2.53%

分子结构信息

SMILES: CN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
InChI: InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1

描述信息

Cepharanthine is a bisbenzylisoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. It is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.
Cepharanthine is a natural product found in Stephania sinica, Stephania cephalantha, and other organisms with data available.
A bisbenzylisoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation.
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
D018501 - Antirheumatic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Origin: Plant; SubCategory_DNP: Isoquinoline alkaloids, Benzylisoquinoline alkaloids
Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50\\%) inhibitory concentration (IC50) and 90\\% inhibitory concentration (IC90) values of 1.90 and 4.46?μM[1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model[2][3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects[4][5][6][7][8].
Cepharanthine is a natural product that can be isolated from the plant Stephania?cephalantha?Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50\%) inhibitory concentration (IC50) and 90\% inhibitory concentration (IC90) values of 1.90 and 4.46?μM[1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model[2][3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects[4][5][6][7][8].

同义名列表

27 个代谢物同义名

(14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2(16,19).1(3,10).1(21,25).0(4,8).0(14,39).0(31,35)]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene; (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene; (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2??,??.1?,??.1??,??.0?,?.0??,??.0??,??]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene; 22,33-Dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene; Oxyacanthan, 6,12-dimethoxy-2,2-dimethyl-6,7-(methylenebis(oxy))-; 6,12-dimethoxy-2,2-dimethyl-6,7-(methylenebis(oxy))oxyacanthan; 4-27-00-09061 (Beilstein Handbook Reference); Cepharanthine, >=98\\% (HPLC); Cepharanthine, >=95\\% (HPLC); 12-O-Methylcepharanoline; CEPHARANTHINE [WHO-DD]; O-Methylcepharanoline; Cepharanthine [JAN]; Cepharanthine (JAN); CEPHARANTHINE [MI]; Cepharanthine (TN); (+)-Cepharanthine; Spectrum3_001963; Spectrum2_000832; Cepharanthin,(S); Tox21_111483_1; Cepharanthine; cepharanthin; Tox21_111483; KBio3_002909; Cepharantin; 1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2,3:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-,(14aS,26aR)-

数据库引用编号

23 个数据库交叉引用编号

ChEBI: CHEBI:3546
KEGG: C09391
KEGGdrug: D01035
PubChem: 10206
PubChem: 360849
Metlin: METLIN44097
DrugBank: DB16824
ChEMBL: CHEMBL449782
ChEMBL: CHEMBL1473842
Wikipedia: Cepharanthine
MeSH: cepharanthine
ChemIDplus: 0000481492
chemspider: 9791
CAS: 481-49-2
MoNA: CCMSLIB00005720154
MoNA: CB000091
medchemexpress: HY-N6972
PMhub: MS000020675
MetaboLights: MTBLC3546
PubChem: 11582
KNApSAcK: C00001836
3DMET: B02925
NIKKAJI: J5.779G

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

26 个相关的物种来源信息

33090 千金藤: -
152367 Stephania cephalantha:
1501472 Stephania sinica:
1924984 Stephania pierrei:
1924985 Stephania suberosa: 10.1021/NP50045A006
1924983 Stephania erecta: 10.1021/NP50091A005
2516453 Stephania corymbosa: 10.1248/YAKUSHI1881.59.8_538
1924984 Stephania pierrei: 10.1021/NP50099A005
1924983 Stephania erecta: 10.1021/NP50099A005
2516453 Stephania corymbosa: 10.1021/NP50091A005
216145 Stephania delavayi: 10.1021/NP50091A005
1501461 Stephania epigaea: 10.1021/NP50091A005
152367 Stephania cephalantha: 10.1021/NP50091A005
152367 Stephania cephalantha:
1501472 Stephania sinica:
1924984 Stephania pierrei:
1924985 Stephania suberosa: 10.1021/NP50045A006
1924983 Stephania erecta: 10.1021/NP50091A005
2516453 Stephania corymbosa: 10.1248/YAKUSHI1881.59.8_538
1924984 Stephania pierrei: 10.1021/NP50099A005
1924983 Stephania erecta: 10.1021/NP50099A005
2516453 Stephania corymbosa: 10.1021/NP50091A005
216145 Stephania delavayi: 10.1021/NP50091A005
1501461 Stephania epigaea: 10.1021/NP50091A005
152367 Stephania cephalantha: 10.1021/NP50091A005
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Jinwen Min, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Cepharanthine synergistically promotes methylprednisolone pharmacodynamics against human peripheral blood mononuclear cells possibly via regulation of P-glycoprotein/glucocorticoid receptor translocation. BMC complementary medicine and therapies. 2024 May; 24(1):186. doi: 10.1186/s12906-024-04489-z. [PMID: 38734604]
Jiangping Yang, Liujie Qin, Shouchang Zhou, Jixing Li, Yu Tu, Minfeng Mo, Xuenian Liu, Jinglun Huang, Xiumei Qin, Aijun Jiao, Wei Wei, Peilin Yang. Network pharmacology, molecular docking and experimental study of CEP in nasopharyngeal carcinoma. Journal of ethnopharmacology. 2024 Apr; 323(?):117667. doi: 10.1016/j.jep.2023.117667. [PMID: 38159821]
Zhuo Liu, Shaoqin Shen, Yujie Wang, Shuqi Sun, Tong Yu, Yanhong Fu, Rong Zhou, Chunjin Li, Rui Cao, Yanshu Zhang, Nan Li, Liangdan Sun, Xiaoming Song. The genome of Stephania japonica provides insights into the biosynthesis of cepharanthine. Cell reports. 2024 Mar; 43(3):113832. doi: 10.1016/j.celrep.2024.113832. [PMID: 38381605]
Yunfang Yang, Changjiang Li, Sijin Yang, Zhuo Zhang, Xue Bai, Hongmei Tang, Jiang Huang. Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway. Aging. 2024 Mar; 16(7):5905-5915. doi: 10.18632/aging.205678. [PMID: 38517394]
Liang Leng, Zhichao Xu, Bixia Hong, Binbin Zhao, Ya Tian, Can Wang, Lulu Yang, Zhongmei Zou, Lingyu Li, Ke Liu, Wanjun Peng, Jiangning Liu, Zhoujie An, Yalin Wang, Baozhong Duan, Zhigang Hu, Chuan Zheng, Sanyin Zhang, Xiaodong Li, Maochen Li, Zhaoyu Liu, Zenghao Bi, Tianxing He, Baimei Liu, Huahao Fan, Chi Song, Yigang Tong, Shilin Chen. Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery. Nature communications. 2024 Feb; 15(1):1537. doi: 10.1038/s41467-024-45690-5. [PMID: 38378731]
Yichao Liang, Jun Li, Honglin Xu, Mingjie Pang, Changlei Hu, Xie Weng, Wei Xie. Cepharanthine suppresses proliferation and metastasis and enhances apoptosis by regulating JAK2/Stat3 pathway in hepatocellular carcinoma. Cellular and molecular biology (Noisy-le-Grand, France). 2023 Dec; 69(14):94-100. doi: 10.14715/cmb/2023.69.14.15. [PMID: 38279472]
Jun Chen, Cheng Lei Xia, Rui Dong, Xian Guo Liu, Jing Xia. Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway. Discovery medicine. 2023 Oct; 35(178):777-786. doi: 10.24976/discov.med.202335178.72. [PMID: 37811615]
YingZheng Wang, Tong Wang, HuaXin Wang, WeiDong Liu, Xiao Li, XiaoYan Wang, YaNan Zhang. A mechanistic updated overview on Cepharanthine as potential anticancer agent. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 165(?):115107. doi: 10.1016/j.biopha.2023.115107. [PMID: 37423171]
Ke Liu, Bixia Hong, Shuqi Wang, Fuxing Lou, Yecheng You, Ruolan Hu, Amna Shafqat, Huahao Fan, Yigang Tong. Pharmacological Activity of Cepharanthine. Molecules (Basel, Switzerland). 2023 Jun; 28(13):. doi: 10.3390/molecules28135019. [PMID: 37446681]
Liangliang Shi, Shuaizhe Wang, Shangzu Zhang, Jiawei Wang, Yaping Chen, Yangyang Li, Zhiwei Liu, Sichen Zhao, Benjun Wei, Liying Zhang. Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Jun; ?(?):. doi: 10.1007/s00210-023-02537-y. [PMID: 37338575]
Aswad Khadilkar, Zoie L Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M Oda, Warren S Vidar, Trevor N Clark, Preston K Manwill, Daniel A Todd, Sarah A Barr, Lauren K Olinger, Susan L Fink, Wendy K Strangman, Roger G Linington, John B MacMillan, Nadja B Cech, Stephen J Polyak. Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents. Journal of natural products. 2023 Apr; 86(4):1061-1073. doi: 10.1021/acs.jnatprod.3c00159. [PMID: 37043739]
Di Liang, Qi Li, Lina Du, Guifang Dou. Pharmacological Effects and Clinical Prospects of Cepharanthine. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248933. [PMID: 36558061]
Xiang-Yan Wei, Jian-Dong Long, Jing-Rui Chai, Jing Chen, Jian-Ping Gao, Yu-Jun Wang, Jing-Gen Liu. Antinociceptive activities and mechanism of action of Cepharanthine. Biochemical and biophysical research communications. 2022 07; 614(?):219-224. doi: 10.1016/j.bbrc.2022.04.083. [PMID: 35636221]
H Fan, K Liu, B Hong, S He, P Han, M Li, S Wang, Y Tong. [Progress in the study of antiviral activity of cepharanthine against SARS-CoV-2]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2022 Jun; 42(6):955-956. doi: 10.12122/j.issn.1673-4254.2022.06.22. [PMID: 35790449]
Jian Li, Guangrui Chen, Zhiyun Meng, Zhuona Wu, Hui Gan, Xiaoxia Zhu, Peng Han, Taoyun Liu, Fanjun Wang, Ruolan Gu, Guifang Dou. Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092745. [PMID: 35566097]
Atsushi Hijikata, Clara Shionyu-Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Takatsugu Hirokawa, Shogo Nakajima, Koichi Watashi, Tsuyoshi Shirai. Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2. FEBS open bio. 2022 01; 12(1):285-294. doi: 10.1002/2211-5463.13337. [PMID: 34850606]
Shiqi Gao, Liuzhi Zhou, Jianan Lu, Yuanjian Fang, Haijian Wu, Weilin Xu, Yuanbo Pan, Junjie Wang, Xiaoyu Wang, Jianmin Zhang, Anwen Shao. Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15-Lipoxygenase-1-Mediated Microglia and Endothelial Cell Ferroptosis. Oxidative medicine and cellular longevity. 2022; 2022(?):4295208. doi: 10.1155/2022/4295208. [PMID: 35186185]
Caihong Lu, Jinpeng Zheng, Yaning Ding, Yuanyuan Meng, Fangyun Tan, Wei Gong, Xiaoyang Chu, Xiaolong Kong, Chunsheng Gao. Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy. Drug delivery. 2021 Dec; 28(1):2582-2593. doi: 10.1080/10717544.2021.2009936. [PMID: 34866533]
Xuan Zhang, Gaohua Zhang, Zhijun Zhao, Ruilian Xiu, Jie Jia, Pingping Chen, Yanshuang Liu, Yuanyuan Wang, Jianfeng Yi. Cepharanthine, a novel selective ANO1 inhibitor with potential for lung adenocarcinoma therapy. Biochimica et biophysica acta. Molecular cell research. 2021 11; 1868(12):119132. doi: 10.1016/j.bbamcr.2021.119132. [PMID: 34450215]
Pan Gao, Zhujun Jiang, Qiao Luo, Chengqiao Mu, Mengsuo Cui, Xinggang Yang. Preparation and Evaluation of Self-emulsifying Drug Delivery System (SEDDS) of Cepharanthine. AAPS PharmSciTech. 2021 Oct; 22(7):245. doi: 10.1208/s12249-021-02085-9. [PMID: 34611770]
Yao Liu, Qiong Tang, Zhili Rao, Yang Fang, Xinni Jiang, Wenjun Liu, Fei Luan, Nan Zeng. Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway. Antiviral research. 2021 09; 193(?):105143. doi: 10.1016/j.antiviral.2021.105143. [PMID: 34303748]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Hongyan Ma, Huiyun Liang, Shengxin Cai, Barry R O'Keefe, Susan L Mooberry, Robert H Cichewicz. An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures. Journal of natural products. 2021 03; 84(3):750-761. doi: 10.1021/acs.jnatprod.0c00946. [PMID: 33226219]
Shasha Li, Wenli Liu, Yangzhen Chen, Liqin Wang, Wenlin An, Xiaoping An, Lihua Song, Yigang Tong, Huahao Fan, Chenyang Lu. Transcriptome analysis of cepharanthine against a SARS-CoV-2-related coronavirus. Briefings in bioinformatics. 2021 03; 22(2):1378-1386. doi: 10.1093/bib/bbaa387. [PMID: 33423067]
Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Molecular mechanisms and therapeutic implications of tetrandrine and cepharanthine in T cell acute lymphoblastic leukemia and autoimmune diseases. Pharmacology & therapeutics. 2021 01; 217(?):107659. doi: 10.1016/j.pharmthera.2020.107659. [PMID: 32800789]
Moshe Rogosnitzky, Paul Okediji, Igor Koman. Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19. Pharmacological reports : PR. 2020 Dec; 72(6):1509-1516. doi: 10.1007/s43440-020-00132-z. [PMID: 32700247]
Xunge Zhang, Ping Feng, Xinfu Gao, Bin Wang, Chunxia Gou, Ruimin Bian. In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes. Pharmaceutical biology. 2020 Dec; 58(1):247-252. doi: 10.1080/13880209.2020.1741650. [PMID: 32223485]
Yinlan Xu, Jiangang Zheng, Panpan Sun, Jianhua Guo, Xiaozhong Zheng, Yaogui Sun, Kuohai Fan, Wei Yin, Hongquan Li, Na Sun. Cepharanthine and Curcumin inhibited mitochondrial apoptosis induced by PCV2. BMC veterinary research. 2020 Sep; 16(1):345. doi: 10.1186/s12917-020-02568-0. [PMID: 32948186]
Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Hongguang Wu, Haruki Yamada, Toshihiko Hirano. Bisbenzylisoquinoline alkaloids and P-glycoprotein function: A structure activity relationship study. Bioorganic & medicinal chemistry. 2020 06; 28(12):115553. doi: 10.1016/j.bmc.2020.115553. [PMID: 32503690]
Rami A Ballout, Dmitri Sviridov, Michael I Bukrinsky, Alan T Remaley. The lysosome: A potential juncture between SARS-CoV-2 infectivity and Niemann-Pick disease type C, with therapeutic implications. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 06; 34(6):7253-7264. doi: 10.1096/fj.202000654r. [PMID: 32367579]
Hua-Hao Fan, Li-Qin Wang, Wen-Li Liu, Xiao-Ping An, Zhen-Dong Liu, Xiao-Qi He, Li-Hua Song, Yi-Gang Tong. Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model. Chinese medical journal. 2020 May; 133(9):1051-1056. doi: 10.1097/cm9.0000000000000797. [PMID: 32149769]
Dong Eon Kim, Jung Sun Min, Min Seong Jang, Jun Young Lee, Young Sup Shin, Jong Hwan Song, Hyoung Rae Kim, Seungtaek Kim, Young-Hee Jin, Sunoh Kwon. Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells. Biomolecules. 2019 11; 9(11):. doi: 10.3390/biom9110696. [PMID: 31690059]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Christian Bailly. Cepharanthine: An update of its mode of action, pharmacological properties and medical applications. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Sep; 62(?):152956. doi: 10.1016/j.phymed.2019.152956. [PMID: 31132753]
Wencheng Xu, Xiaoqin Wang, Yuanchao Tu, Hiroshi Masaki, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells. Chemico-biological interactions. 2019 Sep; 310(?):108726. doi: 10.1016/j.cbi.2019.108726. [PMID: 31255635]
Sk Abrar Shahriyar, Seon Min Woo, Seung Un Seo, Kyoung-Jin Min, Taeg Kyu Kwon. Cepharanthine Enhances TRAIL-Mediated Apoptosis Through STAMBPL1-Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells. International journal of molecular sciences. 2018 Oct; 19(10):. doi: 10.3390/ijms19103280. [PMID: 30360403]
Keiko Aota, Tomoko Yamanoi, Koichi Kani, Masayuki Azuma. Cepharanthine Inhibits IFN-γ-Induced CXCL10 by Suppressing the JAK2/STAT1 Signal Pathway in Human Salivary Gland Ductal Cells. Inflammation. 2018 Feb; 41(1):50-58. doi: 10.1007/s10753-017-0662-x. [PMID: 28879548]
Yingbin Deng, Weijun Wu, Sunzhi Ye, Wei Wang, Zhiyi Wang. Determination of cepharanthine in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Pharmaceutical biology. 2017 Dec; 55(1):1775-1779. doi: 10.1080/13880209.2017.1328446. [PMID: 28521597]
Keshav Raj Paudel, Rajendra Karki, Dong-Wook Kim. Cepharanthine inhibits in vitro VSMC proliferation and migration and vascular inflammatory responses mediated by RAW264.7. Toxicology in vitro : an international journal published in association with BIBRA. 2016 Aug; 34(?):16-25. doi: 10.1016/j.tiv.2016.03.010. [PMID: 27021874]
Yara A Samra, Heba S Said, Nehal M Elsherbiny, Gregory I Liou, Mamdouh M El-Shishtawy, Laila A Eissa. Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome. Life sciences. 2016 Jul; 157(?):187-199. doi: 10.1016/j.lfs.2016.06.002. [PMID: 27266851]
Tomofumi Uto, Masaaki Toyama, Keisuke Yoshinaga, Masanori Baba. Cepharanthine induces apoptosis through the mitochondria/caspase pathway in murine dendritic cells. Immunopharmacology and immunotoxicology. 2016 Jun; 38(3):238-43. doi: 10.3109/08923973.2016.1173059. [PMID: 27121492]
Yin-Kuang Chang, Su-Cheng Huang, Ming-Chang Kao, Chun-Jen Huang. Cepharanthine alleviates liver injury in a rodent model of limb ischemia-reperfusion. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists. 2016 Mar; 54(1):11-5. doi: 10.1016/j.aat.2015.11.004. [PMID: 26711228]
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