PROPAMOCARB (BioDeep_00000002215)

   

natural product


代谢物信息卡片


Pesticide9_Propamocarb_C9H20N2O2_Propyl [3-(dimethylamino)propyl]carbamate

化学式: C9H20N2O2 (188.1525)
中文名称: 甲醇中霜霉威溶液, 霜霉威
谱图信息: 最多检出来源 Homo sapiens(plant) 13.68%

分子结构信息

SMILES: CCCOC(=O)NCCCN(C)C
InChI: InChI=1S/C9H20N2O2/c1-4-8-13-9(12)10-6-5-7-11(2)3/h4-8H2,1-3H3,(H,10,12)

描述信息

CONFIDENCE standard compound; EAWAG_UCHEM_ID 2945
CONFIDENCE standard compound; INTERNAL_ID 1075; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3982; ORIGINAL_PRECURSOR_SCAN_NO 3980
CONFIDENCE standard compound; INTERNAL_ID 1075; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3982; ORIGINAL_PRECURSOR_SCAN_NO 3981
CONFIDENCE standard compound; INTERNAL_ID 1075; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3972; ORIGINAL_PRECURSOR_SCAN_NO 3970
CONFIDENCE standard compound; INTERNAL_ID 1075; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3970; ORIGINAL_PRECURSOR_SCAN_NO 3968
CONFIDENCE standard compound; INTERNAL_ID 1075; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3995; ORIGINAL_PRECURSOR_SCAN_NO 3993
CONFIDENCE standard compound; INTERNAL_ID 1075; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4002; ORIGINAL_PRECURSOR_SCAN_NO 4000
CONFIDENCE standard compound; INTERNAL_ID 648; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3996; ORIGINAL_PRECURSOR_SCAN_NO 3993
CONFIDENCE standard compound; INTERNAL_ID 648; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4000; ORIGINAL_PRECURSOR_SCAN_NO 3998
CONFIDENCE standard compound; INTERNAL_ID 648; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3978; ORIGINAL_PRECURSOR_SCAN_NO 3976
CONFIDENCE standard compound; INTERNAL_ID 648; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3986; ORIGINAL_PRECURSOR_SCAN_NO 3985
CONFIDENCE standard compound; INTERNAL_ID 648; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4015; ORIGINAL_PRECURSOR_SCAN_NO 4014
CONFIDENCE standard compound; INTERNAL_ID 648; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3969; ORIGINAL_PRECURSOR_SCAN_NO 3968
CONFIDENCE standard compound; INTERNAL_ID 2779

同义名列表

4 个代谢物同义名

PROPAMOCARB; Pesticide9_Propamocarb_C9H20N2O2_Propyl [3-(dimethylamino)propyl]carbamate; Propamocarb; Propamocarb



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 APOE, AR, CAPN1, CAT, CD36, FASN, HPGDS, KHK, ME1, OPA1, PKM
Peripheral membrane protein 2 ACHE, HK1
Mitochondrion membrane 1 ABCG2
Nucleus 5 ACHE, APOE, AR, PKM, PPARA
cytosol 11 AR, CAPN1, CAT, FASN, HK1, HPGDS, KHK, ME1, OPA1, PKM, TPH2
dendrite 3 APOE, DRD2, OPA1
mitochondrial membrane 2 ABCG2, OPA1
phagocytic vesicle 1 CD36
nucleoplasm 5 ABCG2, AR, HPGDS, OPA1, PPARA
Cell membrane 7 ABCG2, ACHE, CAPN1, CD36, DRD2, SLC47A2, TNF
Multi-pass membrane protein 5 ABCG2, CD36, DRD2, SLC22A8, SLC47A2
Golgi apparatus membrane 1 DRD2
Synapse 2 ACHE, DRD2
cell surface 3 ACHE, CD36, TNF
glutamatergic synapse 2 APOE, DRD2
Golgi apparatus 4 ACHE, APOE, CD36, FASN
Golgi membrane 1 DRD2
mitochondrial inner membrane 1 OPA1
neuromuscular junction 1 ACHE
neuronal cell body 2 APOE, TNF
presynaptic membrane 1 DRD2
Cytoplasm, cytosol 1 HK1
Lysosome 1 CAPN1
acrosomal vesicle 1 DRD2
plasma membrane 12 ABCG2, ACHE, APOE, AR, CAPN1, CD36, DRD2, FASN, ME1, SLC22A8, SLC47A2, TNF
synaptic vesicle membrane 1 DRD2
Membrane 11 ABCG2, ACHE, APOE, AR, CAPN1, CAT, CD36, FASN, ME1, OPA1, SLC47A2
apical plasma membrane 4 ABCG2, CD36, SLC22A8, SLC47A2
axon 1 DRD2
basolateral plasma membrane 1 SLC22A8
caveola 1 CD36
extracellular exosome 7 APOE, CAPN1, CAT, FASN, KHK, PKM, SLC22A8
endoplasmic reticulum 1 APOE
extracellular space 4 ACHE, APOE, CD36, TNF
perinuclear region of cytoplasm 1 ACHE
mitochondrion 6 CAPN1, CAT, HK1, ME1, OPA1, PKM
protein-containing complex 2 AR, CAT
intracellular membrane-bounded organelle 2 CAT, HPGDS
Secreted 2 ACHE, APOE
extracellular region 6 ACHE, APOE, CAPN1, CAT, PKM, TNF
Mitochondrion outer membrane 1 HK1
Single-pass membrane protein 2 ME1, OPA1
mitochondrial outer membrane 2 HK1, OPA1
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
ciliary membrane 1 DRD2
external side of plasma membrane 2 CD36, TNF
Endosome, multivesicular body 1 APOE
Extracellular vesicle 2 APOE, PKM
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
dendritic spine 1 DRD2
perikaryon 1 DRD2
axon cytoplasm 1 OPA1
Early endosome 1 APOE
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 PKM
postsynaptic membrane 1 DRD2
Apical cell membrane 3 ABCG2, CD36, SLC47A2
Mitochondrion inner membrane 1 OPA1
Membrane raft 4 ABCG2, CD36, HK1, TNF
focal adhesion 2 CAPN1, CAT
microtubule 1 OPA1
GABA-ergic synapse 1 DRD2
extracellular matrix 1 APOE
Peroxisome 1 CAT
basement membrane 1 ACHE
collagen trimer 1 CD36
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 OPA1
mitochondrial intermembrane space 1 OPA1
collagen-containing extracellular matrix 2 APOE, PKM
lateral plasma membrane 2 DRD2, SLC22A8
nuclear speck 1 AR
receptor complex 1 CD36
neuron projection 1 TPH2
cilium 2 DRD2, PKM
chromatin 2 AR, PPARA
phagocytic cup 1 TNF
cell periphery 1 CD36
mitochondrial crista 1 OPA1
Secreted, extracellular space 1 APOE
brush border membrane 2 ABCG2, CD36
blood microparticle 1 APOE
non-motile cilium 1 DRD2
Basolateral cell membrane 1 SLC22A8
Lipid-anchor, GPI-anchor 1 ACHE
sperm flagellum 1 DRD2
Cornified envelope 1 CAPN1
specific granule membrane 1 CD36
Melanosome 2 APOE, FASN
side of membrane 1 ACHE
ficolin-1-rich granule lumen 3 CAPN1, CAT, PKM
secretory granule lumen 2 CAT, PKM
endoplasmic reticulum lumen 1 APOE
axon terminus 1 DRD2
endocytic vesicle membrane 1 CD36
endocytic vesicle 1 DRD2
clathrin-coated endocytic vesicle membrane 1 APOE
synaptic cleft 2 ACHE, APOE
external side of apical plasma membrane 1 ABCG2
dopaminergic synapse 1 DRD2
Rough endoplasmic reticulum 1 PKM
[Dynamin-like GTPase OPA1, long form]: Mitochondrion inner membrane 1 OPA1
[Dynamin-like GTPase OPA1, short form]: Mitochondrion intermembrane space 1 OPA1
platelet alpha granule membrane 1 CD36
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
catalase complex 1 CAT
calpain complex 1 CAPN1
G protein-coupled receptor complex 1 DRD2
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
[Isoform H]: Cell membrane 1 ACHE
glycogen granule 1 FASN
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform 6]: Apical cell membrane 1 SLC47A2


文献列表

  • Cuiyuan Jin, You Weng, Yi Zhang, Zhiwei Bao, Guiling Yang, Zhengwei Fu, Yuanxiang Jin. Propamocarb exposure has the potential to accelerate the formation of atherosclerosis in both WT and ApoE-/- mice accompanied by gut microbiota dysbiosis. The Science of the total environment. 2021 Dec; 800(?):149602. doi: 10.1016/j.scitotenv.2021.149602. [PMID: 34426332]
  • Rosalía López-Ruiz, Roberto Romero-González, Antonia Garrido Frenich. Dissipation kinetics of fenamidone, propamocarb and their metabolites in ambient soil and water samples and unknown screening of metabolites. Journal of environmental management. 2020 Jan; 254(?):109818. doi: 10.1016/j.jenvman.2019.109818. [PMID: 31733475]
  • Fan Zhang, Zhiwei Qin, Xiuyan Zhou, Ming Xin, Shengnan Li, Jie Luan. Expression and functional analysis of the propamocarb-related gene CsMAPEG in cucumber. BMC plant biology. 2019 Aug; 19(1):371. doi: 10.1186/s12870-019-1971-z. [PMID: 31438856]
  • Rui Zhang, Zihong Pan, Xiaoyu Wang, Manlu Shen, Jiajie Zhou, Zhengwei Fu, Yuanxiang Jin. Short-term propamocarb exposure induces hepatic metabolism disorder associated with gut microbiota dysbiosis in adult male zebrafish. Acta biochimica et biophysica Sinica. 2019 Jan; 51(1):88-96. doi: 10.1093/abbs/gmy153. [PMID: 30544157]
  • Sisheng Wu, Ting Luo, Siyu Wang, Jicong Zhou, Yingchun Ni, Zhengwei Fu, Yuanxiang Jin. Chronic exposure to fungicide propamocarb induces bile acid metabolic disorder and increases trimethylamine in C57BL/6J mice. The Science of the total environment. 2018 Nov; 642(?):341-348. doi: 10.1016/j.scitotenv.2018.06.084. [PMID: 29906725]
  • A Thomas, K N Neufeld, K W Seebold, C A Braun, M R Schwarz, P S Ojiambo. Resistance to Fluopicolide and Propamocarb and Baseline Sensitivity to Ethaboxam Among Isolates of Pseudoperonospora cubensis From the Eastern United States. Plant disease. 2018 Aug; 102(8):1619-1626. doi: 10.1094/pdis-10-17-1673-re. [PMID: 30673413]
  • Sisheng Wu, Cuiyuan Jin, Yueyi Wang, Zhengwei Fu, Yuanxiang Jin. Exposure to the fungicide propamocarb causes gut microbiota dysbiosis and metabolic disorder in mice. Environmental pollution (Barking, Essex : 1987). 2018 Jun; 237(?):775-783. doi: 10.1016/j.envpol.2017.10.129. [PMID: 29137890]
  • Chunhong Liu, Zhiwei Qin, Xiuyan Zhou, Ming Xin, Chunhua Wang, Dong Liu, Shengnan Li. Expression and functional analysis of the Propamocarb-related gene CsDIR16 in cucumbers. BMC plant biology. 2018 01; 18(1):16. doi: 10.1186/s12870-018-1236-2. [PMID: 29347906]
  • Ming Xie, Qian Li, Xin-Ping Hu, Yan-Jun Zhang, De-Liang Peng, Xiao-Lin Zhang. Effects of a NTG-based chemical mutagenesis on the propamocarb-tolerance of the nematophagous fungus Lecanicillium attenuatum. Pesticide biochemistry and physiology. 2017 Sep; 141(?):71-75. doi: 10.1016/j.pestbp.2016.11.011. [PMID: 28911743]
  • M Xin, L Wang, B H Ma, Z W Qin, X Y Zhou. Genetic analysis of molecular markers for propamocarb residue in Cucumis sativus using quantitative trait locus mapping. Genetics and molecular research : GMR. 2016 Nov; 15(4):. doi: 10.4238/gmr15048776. [PMID: 27819743]
  • Sandra Halwachs, Ingo Schäfer, Carsten Kneuer, Peter Seibel, Walther Honscha. Assessment of ABCG2-mediated transport of pesticides across the rabbit placenta barrier using a novel MDCKII in vitro model. Toxicology and applied pharmacology. 2016 08; 305(?):66-74. doi: 10.1016/j.taap.2016.06.007. [PMID: 27288731]
  • Chunwei Wang, Yan Wang, Jie Gao, Yuncheng Xu, Lili Cui. Dissipation and residues determination of propamocarb in ginseng and soil by high-performance liquid chromatography coupled with tandem mass spectrometry. Environmental monitoring and assessment. 2014 Sep; 186(9):5327-36. doi: 10.1007/s10661-014-3781-y. [PMID: 24791956]
  • J U Blandón-Díaz, A-K Widmark, A Hannukkala, B Andersson, N Högberg, J E Yuen. Phenotypic variation within a clonal lineage of Phytophthora infestans infecting both tomato and potato in Nicaragua. Phytopathology. 2012 Mar; 102(3):323-30. doi: 10.1094/phyto-02-11-0033. [PMID: 22085300]
  • M L Gullino, G Gilardi, A Garibaldi. Chemical control of downy mildew on lettuce and basil under greenhouse. Communications in agricultural and applied biological sciences. 2009; 74(3):933-40. doi: . [PMID: 20222581]
  • Halina I Falfushinska, Liliya D Romanchuk, Oksana B Stolyar. Different responses of biochemical markers in frogs (Rana ridibunda) from urban and rural wetlands to the effect of carbamate fungicide. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2008 Sep; 148(3):223-9. doi: 10.1016/j.cbpc.2008.05.018. [PMID: 18585479]
  • C Skrzypczak. Downy mildews on ornamental plants and their control. Communications in agricultural and applied biological sciences. 2006; 71(3 Pt B):1013-6. doi: . [PMID: 17390852]
  • Zhao-xiang Chai, Jin-hua Li, Min-quan Li, Ke-yong Dong, Yong-liang Wei. [Field test and lab experiment on control efficacy of the pathogen of opium poppy mildew]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2002 Jul; 27(7):502-5. doi: ". [PMID: 12776513]
  • R Aerts, B De Schutter, L Rombouts. Suppression of Pythium spp. by Trichoderma spp. during germination of tomato seeds in soilless growing media. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen). 2002; 67(2):343-51. doi: . [PMID: 12701442]
  • B De Schutter, R Aerts, L Rombouts. The influence of fungicides on the growth of Trichoderma asperellum. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen). 2002; 67(2):291-8. doi: ". [PMID: 12701435]