Tacrolimus (BioDeep_00000000218)

 

Secondary id: BioDeep_00000399326

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycycl ohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-

化学式: C44H69NO12 (803.4819514)
中文名称: 他克莫司
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.38%

分子结构信息

SMILES: C=CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC
InChI: InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

描述信息

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patients immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
It is used in foods as emulsifier, stabiliser, thickener, gelling agent, formulation aid and firming agent; ice-cream stabiliser, used to improve the yield of curds in soft cheese, to increase the yield of doughs and baked products, as a binder and lubricant in sausages, and as thickener or viscosity control agent in beverages, salad dressings and relishes
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents > D016559 - Tacrolimus
D004791 - Enzyme Inhibitors > D065095 - Calcineurin Inhibitors
Tacrolimus (anhydrous) is a macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. It has a role as an immunosuppressive agent and a bacterial metabolite.
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patients immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL-2 transcription.
Tacrolimus anhydrous is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of tacrolimus anhydrous is as a Calcineurin Inhibitor.
Tacrolimus is a calcineurin inhibitor and potent immunosuppressive agent used largely as a means of prophylaxis against cellular rejection after transplantation. Tacrolimus therapy can be associated with mild serum enzyme elevations, and it has been linked to rare instances of clinically apparent cholestatic liver injury.
Tacrolimus is a natural product found in Streptomyces clavuligerus, Streptomyces hygroscopicus, and other organisms with data available.
Tacrolimus is a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.
Tacrolimus Anhydrous is anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
D - Dermatologicals > D11 - Other dermatological preparations > D11A - Other dermatological preparations > D11AH - Agents for dermatitis, excluding corticosteroids
L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants > L04AD - Calcineurin inhibitors
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C146638 - Calcineurin Inhibitor
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同义名列表

74 个代谢物同义名

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone; (1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0^{4,9}]octacos-18-ene-2,3,10,16-tetrone; Fujisawa brand OF tacrolimus; Janssen brand OF tacrolimus; Cilag brand OF tacrolimus; Tacrolimus, anhydrous; Anhydrous, Tacrolimus; Tacrolimus anhydrous; Anhydrous Tacrolimus; Tacrolimus; Guar gum; Prograft; Prograf; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycycl ohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone; (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone; (1R,9S,12S,13R,14S,17R,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-{1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0,4,9]octacos-18-ene-2,3,10,16-tetrone; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26AS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-HEXADECAHYDRO-5,19-DIHYDROXY-3-[(1E)-2-[(1R,3R,4R)-4-HYDROXY-3-METHOXYCYCLOHEXYL]-1-METHYLETHENYL]-14,16-DIMETHOXY-4,10,12,18-TETRAMETHYL-8-(2-PROPEN-1-YL)-15,19; (E)-(1R,9S,12S,13R,14R,21S,23S,24R,25S,27R)-17-Allyl-1,14-dihydroxy-12-[(E)-2-((3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0*4,9*]octacos-18-ene-2,3,10,16-tetraone; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyc; lohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-; 4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-heptadecahydro-5,19-dihydroxy-3-; 15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,; [(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-; TACROLIMUS MONOHYDRATE (EP MONOGRAPH); 8-DEETHYL-8-(BUT-3-ENYL)-ASCOMYCIN; 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN; Tacrolimus in whole human blood; QJJXYPPXXYFBGM-LFZNUXCKSA-N; TACROLIMUS (USP MONOGRAPH); Tacrolimus (anhydrous); Tacrolimus [USAN:INN]; TACROLIMUS [WHO-DD]; TACROLIMUS (USP-RS); TACROLIMUS [MART.]; TACROLIMUS (MART.); Tacrolimus [USAN]; Tacrolimus (INN); TACROLIMUS [INN]; UNII-Y5L2157C4J; TACROLIMUS [MI]; UNII-WM0HAQ4WNM; Tsukubaenolide; C44H69NO12.H2O; tacrolimusum; Prograf (TN); Tox21_112056; IDI1_001040; Astagraf XL; Envarsus XR; ENVARSUS-XR; Y5L2157C4J; Graceptor; Fujimycin; LCP-Tacro; Advagraf; Envarsus; Protopic; PROGRAPH; Modigraf; Avagraf; Hecoria; L04AD02; Protopy; Talymus; D11AH01; Fk-506; TACRO; Tacrolimus



数据库引用编号

30 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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167 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Na Lei, Xuechen Cao, Yifei Feng, Guoyan Liu, Jianqing Feng, Yidong Zhao, Zhiming Zhao, Ziyu Li, Lebin Song, Yan Lu. A novel reverse perilesional home phototherapy can promote the repigmentation of vitiligo patches with complete leukotrichia: A 12-week, open-label, double-arm, multicenter, randomized clinical trial. Photodermatology, photoimmunology & photomedicine. 2024 May; 40(3):e12974. doi: 10.1111/phpp.12974. [PMID: 38728444]
  • Yue Du, Yundi Zhang, Zhiyan Yang, Yue Li, Xinyu Wang, Ziqiang Li, Lei Ren, Yan Li. Artificial Neural Network Analysis of Determinants of Tacrolimus Pharmacokinetics in Liver Transplant Recipients. The Annals of pharmacotherapy. 2024 May; 58(5):469-479. doi: 10.1177/10600280231190943. [PMID: 37559252]
  • Ashwani Mehta. Managing dyslipidemia in solid organ transplant patients. Indian heart journal. 2024 Mar; 76 Suppl 1(?):S93-S95. doi: 10.1016/j.ihj.2024.01.004. [PMID: 38199560]
  • Ting Hui Woon, Melissa Jia Hui Tan, Yu Heng Kwan, Warren Fong. Evidence of the interactions between immunosuppressive drugs used in autoimmune rheumatic diseases and Chinese herbal medicine: A scoping review. Complementary therapies in medicine. 2024 Mar; 80(?):103017. doi: 10.1016/j.ctim.2024.103017. [PMID: 38218549]
  • Alexandra Bergen, James Herrmann, Christopher M Reilly. Xanthogranulomatous keratitis in a mixed-breed dog. Journal of the American Veterinary Medical Association. 2024 Jan; ?(?):1-4. doi: 10.2460/javma.23.10.0548. [PMID: 38266392]
  • Katja S Gümüs, Anna Teegelbekkers, Max Sauter, Andreas D Meid, Jürgen Burhenne, Johanna Weiss, Antje Blank, Walter E Haefeli, David Czock. Effect of Tacrolimus Formulation (Prolonged-Release vs Immediate-Release) on Its Susceptibility to Drug-Drug Interactions with St. John's Wort. Clinical pharmacology in drug development. 2024 Jan; ?(?):. doi: 10.1002/cpdd.1364. [PMID: 38176912]
  • Mingdan Zhao, Fujun Huang, Lei Tang, Xun Zhou, Miao Zhang, Mengxue Liao, Lirong Liu, Mengya Huang. Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus. Frontiers in immunology. 2024; 15(?):1354578. doi: 10.3389/fimmu.2024.1354578. [PMID: 38566985]
  • Yu Zhu, Junyi Chen, Yao Zhang, Xiaoai Wang, Jingjing Wang. Immunosuppressive agents for frequently relapsing/steroid-dependent nephrotic syndrome in children: a systematic review and network meta-analysis. Frontiers in immunology. 2024; 15(?):1310032. doi: 10.3389/fimmu.2024.1310032. [PMID: 38464533]
  • Juliana Viegas, Sofia Dias, Ana Margarida Carvalho, Bruno Sarmento. Characterization of a human lesioned-skin model to assess the influence of skin integrity on drug permeability. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 169(?):115841. doi: 10.1016/j.biopha.2023.115841. [PMID: 37944442]
  • Violetta Dziedziejko, Krzysztof Safranow, Mirosława Kijko-Nowak, Damian Malinowski, Leszek Domanski, Andrzej Pawlik. Leptin receptor gene polymorphisms in kidney transplant patients with post-transplant diabetes mellitus treated with tacrolimus. International immunopharmacology. 2023 Sep; 124(Pt B):110989. doi: 10.1016/j.intimp.2023.110989. [PMID: 37776770]
  • Wei Luo, Yu He, Mao Gang Wei, Guang Bing Lu, Qun Yi. Paxlovid-tacrolimus drug-drug interaction caused severe diarrhea that induced combined diabetic ketoacidosis and a hyperglycemic hyperosmolar state in a kidney transplant patient: a case report. Journal of medical case reports. 2023 Sep; 17(1):406. doi: 10.1186/s13256-023-04135-1. [PMID: 37742028]
  • Yundi Zhang, Yue Du, Shuyu Ren, Yue Li, Xiaoming Zhang, Xiaohong Cao, Fengxi Liu, Huiying Zong, Yan Li. CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Voriconazole in Chinese Kidney Transplant Patients. The Annals of pharmacotherapy. 2023 Sep; ?(?):10600280231197399. doi: 10.1177/10600280231197399. [PMID: 37702380]
  • Nguyen Thi Hai Yen, Nguyen Ky Phat, Jung-Hwa Oh, Se-Myo Park, Kyoung-Sik Moon, Vo Thuy Anh Thu, Yong-Soon Cho, Jae-Gook Shin, Nguyen Phuoc Long, Dong Hyun Kim. Pathway-level multi-omics analysis of the molecular mechanisms underlying the toxicity of long-term tacrolimus exposure. Toxicology and applied pharmacology. 2023 08; 473(?):116597. doi: 10.1016/j.taap.2023.116597. [PMID: 37321324]
  • Li-Jian Chen, Yang Xin, Miao-Xian Yuan, Chun-Yi Ji, Yu-Ming Peng, Qiang Yin. CircFOXN2 alleviates glucocorticoid- and tacrolimus-induced dyslipidemia by reducing FASN mRNA stability by binding to PTBP1 during liver transplantation. American journal of physiology. Cell physiology. 2023 Aug; ?(?):. doi: 10.1152/ajpcell.00462.2022. [PMID: 37575056]
  • Yujie Li, Hui Ren, Fanlong Wang, Jianjun Chen, Lian Ma, Yang Chen, Xianbi Li, Yanhua Fan, Dan Jin, Lei Hou, Yonghong Zhou, Nemat O Keyhani, Yan Pei. Cell detoxification of secondary metabolites by P4-ATPase-mediated vesicle transport. eLife. 2023 07; 12(?):. doi: 10.7554/elife.79179. [PMID: 37405392]
  • Junmiao Xu, Sihui Wang. Successful complementary therapy with Chinese herbal medicine in a patient with refractory symptoms from systemic lupus erythematosus: A case report. Explore (New York, N.Y.). 2023 Jun; ?(?):. doi: 10.1016/j.explore.2023.06.010. [PMID: 37385892]
  • T Tan, Y Zheng, Y Li, Y Zeng. [Pharmacogenetic testing improves treatment responses in patients with PLA2R-related membranous nephropathy]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 Jun; 43(6):1047-1050. doi: 10.12122/j.issn.1673-4254.2023.06.23. [PMID: 37439180]
  • Zhensheng Zhang, Li Xu, Xun Qiu, Xinyu Yang, Zhengxing Lian, Xuyong Wei, Di Lu, Xiao Xu. Fibroblast growth factor 21 (FGF21) attenuates tacrolimus-induced hepatic lipid accumulation through transcription factor EB (TFEB)-regulated lipophagy. Journal of Zhejiang University. Science. B. 2023 Jun; 24(6):485-495. doi: 10.1631/jzus.b2200562. [PMID: 37309040]
  • Berk Goktepe, Aygul Celtik, Goktug Kivratma, Taylan Ozgur Sezer, Gulay Asci, Huseyin Toz. Is Serum Magnesium Level Associated With Serum Lipid Levels in Kidney Transplant Recipients?. Transplantation proceedings. 2023 Apr; ?(?):. doi: 10.1016/j.transproceed.2023.01.041. [PMID: 37045703]
  • Neng Zhang, Shiqian Feng, Ye Tian, Ling Zhuang, Gan Cha, Saiya Duan, Hongmei Li, Xiangqun Nong, Zehua Zhang, Xiongbing Tu, Guangjun Wang. Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria. Scientific reports. 2023 03; 13(1):4048. doi: 10.1038/s41598-023-30889-1. [PMID: 36899085]
  • Xiang Zheng, Weijie Zhang, Hua Zhou, Ronghua Cao, Zhangfei Shou, Shuwei Zhang, Ying Cheng, Xuchun Chen, Chenguang Ding, Ning Li, Shaohua Shi, Qiang Zhou, Qiuyuan Chen, Gang Chen, Zheng Chen, Peijun Zhou, Xiaopeng Hu, Wujun Xue, Xiaodong Zhang, Ning Na, Wei Wang. A multi-center randomized controlled trial to evaluate efficacy and safety of early conversion to a low-dose calcineurin inhibitor combined with sirolimus in renal transplant patients. Chinese medical journal. 2023 03; 136(5):607-609. doi: 10.1097/cm9.0000000000002604. [PMID: 36921118]
  • Maryam Salari, Mohammad Ali Yaghoubi, Maryam Miri, Hassan Mehrad-Majd, Maryam Hami. Association of Metabolic Syndrome and Hyperuricemia in the Recipients of Kidney Transplants: A Single-Center Study. Iranian journal of kidney diseases. 2023 03; 1(2):100-107. doi: ". [PMID: 37060344]
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  • Burcu Azak Pazarlar, Cansu Bilister Egilmez, Mumin Alper Erdogan, Oytun Erbas. Immunosuppressant Tacrolimus Treatment Delays Acute Seizure Occurrence, Reduces Elevated Oxidative Stress, and Reverses PGF2α Burst in the Brain of PTZ-Treated Rats. Neurochemical research. 2023 Feb; ?(?):. doi: 10.1007/s11064-023-03885-0. [PMID: 36780043]
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