Tacrolimus (BioDeep_00000000218)

 

Secondary id: BioDeep_00000399326

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycycl ohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-

化学式: C44H69NO12 (803.482)
中文名称: 他克莫司
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 66.62%

分子结构信息

SMILES: C=CCC1C=C(C)CC(C)CC(OC)C2OC(O)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)=CC3CCC(O)C(OC)C3)C(C)C(O)CC1=O)C(C)CC2OC
InChI: InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

描述信息

Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patients immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
It is used in foods as emulsifier, stabiliser, thickener, gelling agent, formulation aid and firming agent; ice-cream stabiliser, used to improve the yield of curds in soft cheese, to increase the yield of doughs and baked products, as a binder and lubricant in sausages, and as thickener or viscosity control agent in beverages, salad dressings and relishes
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents > D016559 - Tacrolimus
D004791 - Enzyme Inhibitors > D065095 - Calcineurin Inhibitors
Tacrolimus (anhydrous) is a macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. It has a role as an immunosuppressive agent and a bacterial metabolite.
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patients immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL-2 transcription.
Tacrolimus anhydrous is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of tacrolimus anhydrous is as a Calcineurin Inhibitor.
Tacrolimus is a calcineurin inhibitor and potent immunosuppressive agent used largely as a means of prophylaxis against cellular rejection after transplantation. Tacrolimus therapy can be associated with mild serum enzyme elevations, and it has been linked to rare instances of clinically apparent cholestatic liver injury.
Tacrolimus is a natural product found in Streptomyces clavuligerus, Streptomyces hygroscopicus, and other organisms with data available.
Tacrolimus is a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.
Tacrolimus Anhydrous is anhydrous from of tacrolimus, a macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
D - Dermatologicals > D11 - Other dermatological preparations > D11A - Other dermatological preparations > D11AH - Agents for dermatitis, excluding corticosteroids
L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants > L04AD - Calcineurin inhibitors
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C146638 - Calcineurin Inhibitor
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同义名列表

74 个代谢物同义名

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone; (1R,9S,12S,13R,14S,17R,18Z,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0^{4,9}]octacos-18-ene-2,3,10,16-tetrone; Fujisawa brand OF tacrolimus; Janssen brand OF tacrolimus; Cilag brand OF tacrolimus; Tacrolimus, anhydrous; Anhydrous, Tacrolimus; Tacrolimus anhydrous; Anhydrous Tacrolimus; Tacrolimus; Guar gum; Prograft; Prograf; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycycl ohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone; (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone; (1R,9S,12S,13R,14S,17R,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-{1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0,4,9]octacos-18-ene-2,3,10,16-tetrone; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26AS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-HEXADECAHYDRO-5,19-DIHYDROXY-3-[(1E)-2-[(1R,3R,4R)-4-HYDROXY-3-METHOXYCYCLOHEXYL]-1-METHYLETHENYL]-14,16-DIMETHOXY-4,10,12,18-TETRAMETHYL-8-(2-PROPEN-1-YL)-15,19; (E)-(1R,9S,12S,13R,14R,21S,23S,24R,25S,27R)-17-Allyl-1,14-dihydroxy-12-[(E)-2-((3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0*4,9*]octacos-18-ene-2,3,10,16-tetraone; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyc; lohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-; dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-; 4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-heptadecahydro-5,19-dihydroxy-3-; 15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone,; [(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-; TACROLIMUS MONOHYDRATE (EP MONOGRAPH); 8-DEETHYL-8-(BUT-3-ENYL)-ASCOMYCIN; 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN; Tacrolimus in whole human blood; QJJXYPPXXYFBGM-LFZNUXCKSA-N; TACROLIMUS (USP MONOGRAPH); Tacrolimus (anhydrous); Tacrolimus [USAN:INN]; TACROLIMUS [WHO-DD]; TACROLIMUS (USP-RS); TACROLIMUS [MART.]; TACROLIMUS (MART.); Tacrolimus [USAN]; Tacrolimus (INN); TACROLIMUS [INN]; UNII-Y5L2157C4J; TACROLIMUS [MI]; UNII-WM0HAQ4WNM; Tsukubaenolide; C44H69NO12.H2O; tacrolimusum; Prograf (TN); Tox21_112056; IDI1_001040; Astagraf XL; Envarsus XR; ENVARSUS-XR; Y5L2157C4J; Graceptor; Fujimycin; LCP-Tacro; Advagraf; Envarsus; Protopic; PROGRAPH; Modigraf; Avagraf; Hecoria; L04AD02; Protopy; Talymus; D11AH01; Fk-506; TACRO; Tacrolimus



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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167 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ACE, CD34, DMD, NR3C1
Peripheral membrane protein 2 DMD, SRL
Endosome membrane 1 HLA-A
Endoplasmic reticulum membrane 2 CD4, HLA-A
Nucleus 3 DMD, FKBP3, NR3C1
cytosol 2 DMD, NR3C1
centrosome 1 NR3C1
nucleoplasm 2 MS4A1, NR3C1
Cell membrane 7 ACE, CD19, CD4, CD40LG, HLA-A, MS4A1, SLCO1B1
Lipid-anchor 1 MS4A1
Cytoplasmic side 1 DMD
Early endosome membrane 1 HLA-A
Multi-pass membrane protein 2 MS4A1, SLCO1B1
Synapse 2 DMD, NR3C1
cell surface 4 CD40LG, DMD, HLA-A, MS4A1
Golgi apparatus 2 CD40LG, HLA-A
Golgi membrane 1 HLA-A
lysosomal membrane 1 HLA-A
sarcolemma 1 DMD
Lysosome 2 ACE, CD34
endosome 1 ACE
plasma membrane 12 ACE, CD19, CD34, CD4, CD40LG, CSF2, DMD, HLA-A, IL2RA, MS4A1, REN, SLCO1B1
Membrane 11 ACE, CD19, CD34, CD40LG, DMD, HLA-A, IL2RA, MS4A1, NR3C1, REN, SLCO1B1
apical plasma membrane 1 CD34
basolateral plasma membrane 1 SLCO1B1
extracellular exosome 4 ACE, CD19, HLA-A, MS4A1
Lysosome membrane 1 HLA-A
endoplasmic reticulum 1 HLA-A
extracellular space 11 ACE, CCL2, CD40LG, CSF2, CSF3, CXCL8, HLA-A, MS4A1, REN, TCN1, TG
lysosomal lumen 1 CSF3
perinuclear region of cytoplasm 1 CD34
mitochondrion 1 NR3C1
protein-containing complex 3 CD19, DMD, NR3C1
intracellular membrane-bounded organelle 1 CSF2
filopodium 1 DMD
Single-pass type I membrane protein 6 ACE, CD19, CD34, CD4, HLA-A, IL2RA
Secreted 8 ACE, CCL2, CD40LG, CSF2, CSF3, CXCL8, REN, TG
extracellular region 9 ACE, CCL2, CD34, CSF2, CSF3, CXCL8, REN, TCN1, TG
Single-pass membrane protein 1 HLA-A
mitochondrial matrix 1 NR3C1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
external side of plasma membrane 8 ACE, CD19, CD34, CD4, CD40LG, HLA-A, IL2RA, MS4A1
Z disc 1 DMD
Early endosome 1 CD4
apical part of cell 1 REN
Single-pass type II membrane protein 1 CD40LG
postsynaptic membrane 1 DMD
Cell membrane, sarcolemma 1 DMD
Membrane raft 3 CD19, CD4, DMD
Cytoplasm, cytoskeleton 1 DMD
Cytoplasm, cytoskeleton, spindle 1 NR3C1
spindle 1 NR3C1
nuclear speck 1 NR3C1
Nucleus outer membrane 1 DMD
nuclear outer membrane 1 DMD
Postsynaptic cell membrane 1 DMD
chromatin 1 NR3C1
phagocytic vesicle membrane 1 HLA-A
Chromosome 1 NR3C1
cytoskeleton 1 DMD
brush border membrane 1 ACE
sperm midpiece 1 ACE
Basolateral cell membrane 1 SLCO1B1
intercellular bridge 1 CD34
Recycling endosome membrane 1 HLA-A
Nucleus, nucleoplasm 1 NR3C1
filopodium membrane 1 DMD
basal plasma membrane 3 ACE, CD34, SLCO1B1
plasma membrane raft 1 MS4A1
endoplasmic reticulum lumen 1 CD4
specific granule lumen 1 TCN1
tertiary granule lumen 1 TCN1
Sarcoplasmic reticulum membrane 1 SRL
endoplasmic reticulum exit site 1 HLA-A
Single-pass type IV membrane protein 1 DMD
ER to Golgi transport vesicle membrane 1 HLA-A
clathrin-coated endocytic vesicle membrane 1 CD4
Sarcoplasmic reticulum lumen 1 SRL
costamere 1 DMD
Basal cell membrane 1 SLCO1B1
lumenal side of endoplasmic reticulum membrane 1 HLA-A
MHC class I peptide loading complex 1 HLA-A
dystrophin-associated glycoprotein complex 1 DMD
cell-substrate junction 1 DMD
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
[Isoform Alpha]: Cytoplasm 1 NR3C1
Golgi medial cisterna 1 HLA-A
endocytic vesicle lumen 1 CSF3
interleukin-2 receptor complex 1 IL2RA
T cell receptor complex 1 CD4
MHC class I protein complex 1 HLA-A
MHC class II protein complex 1 HLA-A
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
neuron projection terminus 1 DMD
syntrophin complex 1 DMD
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
glomerular endothelium fenestra 1 CD34
[CD40 ligand, soluble form]: Secreted 1 CD40LG
organelle 1 DMD
plasma membrane bounded cell projection 1 DMD


文献列表

  • Na Lei, Xuechen Cao, Yifei Feng, Guoyan Liu, Jianqing Feng, Yidong Zhao, Zhiming Zhao, Ziyu Li, Lebin Song, Yan Lu. A novel reverse perilesional home phototherapy can promote the repigmentation of vitiligo patches with complete leukotrichia: A 12-week, open-label, double-arm, multicenter, randomized clinical trial. Photodermatology, photoimmunology & photomedicine. 2024 May; 40(3):e12974. doi: 10.1111/phpp.12974. [PMID: 38728444]
  • Yue Du, Yundi Zhang, Zhiyan Yang, Yue Li, Xinyu Wang, Ziqiang Li, Lei Ren, Yan Li. Artificial Neural Network Analysis of Determinants of Tacrolimus Pharmacokinetics in Liver Transplant Recipients. The Annals of pharmacotherapy. 2024 May; 58(5):469-479. doi: 10.1177/10600280231190943. [PMID: 37559252]
  • Ashwani Mehta. Managing dyslipidemia in solid organ transplant patients. Indian heart journal. 2024 Mar; 76 Suppl 1(?):S93-S95. doi: 10.1016/j.ihj.2024.01.004. [PMID: 38199560]
  • Ting Hui Woon, Melissa Jia Hui Tan, Yu Heng Kwan, Warren Fong. Evidence of the interactions between immunosuppressive drugs used in autoimmune rheumatic diseases and Chinese herbal medicine: A scoping review. Complementary therapies in medicine. 2024 Mar; 80(?):103017. doi: 10.1016/j.ctim.2024.103017. [PMID: 38218549]
  • Alexandra Bergen, James Herrmann, Christopher M Reilly. Xanthogranulomatous keratitis in a mixed-breed dog. Journal of the American Veterinary Medical Association. 2024 Jan; ?(?):1-4. doi: 10.2460/javma.23.10.0548. [PMID: 38266392]
  • Katja S Gümüs, Anna Teegelbekkers, Max Sauter, Andreas D Meid, Jürgen Burhenne, Johanna Weiss, Antje Blank, Walter E Haefeli, David Czock. Effect of Tacrolimus Formulation (Prolonged-Release vs Immediate-Release) on Its Susceptibility to Drug-Drug Interactions with St. John's Wort. Clinical pharmacology in drug development. 2024 Jan; ?(?):. doi: 10.1002/cpdd.1364. [PMID: 38176912]
  • Mingdan Zhao, Fujun Huang, Lei Tang, Xun Zhou, Miao Zhang, Mengxue Liao, Lirong Liu, Mengya Huang. Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus. Frontiers in immunology. 2024; 15(?):1354578. doi: 10.3389/fimmu.2024.1354578. [PMID: 38566985]
  • Yu Zhu, Junyi Chen, Yao Zhang, Xiaoai Wang, Jingjing Wang. Immunosuppressive agents for frequently relapsing/steroid-dependent nephrotic syndrome in children: a systematic review and network meta-analysis. Frontiers in immunology. 2024; 15(?):1310032. doi: 10.3389/fimmu.2024.1310032. [PMID: 38464533]
  • Juliana Viegas, Sofia Dias, Ana Margarida Carvalho, Bruno Sarmento. Characterization of a human lesioned-skin model to assess the influence of skin integrity on drug permeability. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 169(?):115841. doi: 10.1016/j.biopha.2023.115841. [PMID: 37944442]
  • Violetta Dziedziejko, Krzysztof Safranow, Mirosława Kijko-Nowak, Damian Malinowski, Leszek Domanski, Andrzej Pawlik. Leptin receptor gene polymorphisms in kidney transplant patients with post-transplant diabetes mellitus treated with tacrolimus. International immunopharmacology. 2023 Sep; 124(Pt B):110989. doi: 10.1016/j.intimp.2023.110989. [PMID: 37776770]
  • Wei Luo, Yu He, Mao Gang Wei, Guang Bing Lu, Qun Yi. Paxlovid-tacrolimus drug-drug interaction caused severe diarrhea that induced combined diabetic ketoacidosis and a hyperglycemic hyperosmolar state in a kidney transplant patient: a case report. Journal of medical case reports. 2023 Sep; 17(1):406. doi: 10.1186/s13256-023-04135-1. [PMID: 37742028]
  • Yundi Zhang, Yue Du, Shuyu Ren, Yue Li, Xiaoming Zhang, Xiaohong Cao, Fengxi Liu, Huiying Zong, Yan Li. CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Voriconazole in Chinese Kidney Transplant Patients. The Annals of pharmacotherapy. 2023 Sep; ?(?):10600280231197399. doi: 10.1177/10600280231197399. [PMID: 37702380]
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