Pimozide (BioDeep_00000002076)

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds

代谢物信息卡片

1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one

化学式: C28H29F2N3O (461.22785680000004)
中文名称: 匹莫齐特
谱图信息: 最多检出来源 Mentha canadensis(plant) 11.76%

分子结构信息

SMILES: c1ccc2c(c1)[nH]c(=O)n2C1CCN(CCCC(c2ccc(cc2)F)c2ccc(cc2)F)CC1
InChI: InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)

描述信息

A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AG - Diphenylbutylpiperidine derivatives
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.

同义名列表

16 个代谢物同义名

1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one; Pharmascience brand OF pimozide; ASTA medica brand OF pimozide; Janssen brand OF pimozide; Neoperidole; Orap forte; Pimozidum; Halomonth; Pimozida; pimozide; Antalon; Opiran; Orap; R6238; Pimozide; Pimozide

数据库引用编号

19 个数据库交叉引用编号

ChEBI: CHEBI:8212
KEGG: C07566
KEGGdrug: D00560
PubChem: 16362
HMDB: HMDB0015232
Metlin: METLIN1938
DrugBank: DB01100
ChEMBL: CHEMBL1423
Wikipedia: Pimozide
MeSH: Pimozide
chemspider: 15520
CAS: 2062-78-4
PMhub: MS000001786
PubChem: 9769
PDB-CCD: 1II
NIKKAJI: J3.698F
RefMet: Pimozide
medchemexpress: HY-12987
KNApSAcK: 8212

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Sapna Lonare, Monica Sharma, Vikram Dalal, Mrugendra Gubyad, Pranav Kumar, Deena Nath Gupta, Akshay Pareek, Shailly Tomar, Dilip Kumar Ghosh, Pravindra Kumar, Ashwani Kumar Sharma. Identification and evaluation of potential inhibitor molecules against TcyA from Candidatus Liberibacter asiaticus. Journal of structural biology. 2023 Jun; 215(3):107992. doi: 10.1016/j.jsb.2023.107992. [PMID: 37394197]
Nina Meyer, Lisa Henkel, Benedikt Linder, Svenja Zielke, Georg Tascher, Sandra Trautmann, Gerd Geisslinger, Christian Münch, Simone Fulda, Irmgard Tegeder, Donat Kögel. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy. 2021 11; 17(11):3424-3443. doi: 10.1080/15548627.2021.1874208. [PMID: 33461384]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Yi-Bo Hou, Li-Na Zhang, Hui-Na Wang, Zhen-Fu Zhao, Yue-Tong Sun, Kunmei Ji, Jia-Jie Chen. The antipsychotic drug pimozide inhibits IgE-mediated mast cell degranulation and migration. International immunopharmacology. 2020 Jul; 84(?):106500. doi: 10.1016/j.intimp.2020.106500. [PMID: 32311669]
Rami Al Batran, Keshav Gopal, Megan E Capozzi, Jadin J Chahade, Bruno Saleme, S Amirhossein Tabatabaei-Dakhili, Amanda A Greenwell, Jingjing Niu, Malak Almutairi, Nikole J Byrne, Grant Masson, Ryekjang Kim, Farah Eaton, Erin E Mulvihill, Léa Garneau, Andrea R Masters, Zeruesenay Desta, Carlos A Velázquez-Martínez, Céline Aguer, Peter A Crawford, Gopinath Sutendra, Jonathan E Campbell, Jason R B Dyck, John R Ussher. Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation. Cell metabolism. 2020 05; 31(5):909-919.e8. doi: 10.1016/j.cmet.2020.03.017. [PMID: 32275862]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Xiaochen Yuan, Qingbin Wu, Peng Wang, Yingli Jing, Haijiang Yao, Yinshan Tang, Ruiqin Han, Weili He, Zhigang Li, Honggang Zhang, Ruijuan Xiu. Intraspinal administration of interleukin-7 promotes neuronal apoptosis and limits functional recovery through JAK/STAT5 pathway following spinal cord injury. Biochemical and biophysical research communications. 2019 06; 514(3):1023-1029. doi: 10.1016/j.bbrc.2019.04.159. [PMID: 31068251]
A N Johnston, W Bu, S Hein, S Garcia, L Camacho, L Xue, L Qin, C Nagi, S G Hilsenbeck, J Kapali, K Podsypanina, J Nangia, Y Li. Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions. Breast cancer research : BCR. 2018 05; 20(1):42. doi: 10.1186/s13058-018-0969-z. [PMID: 29778097]
Elisabetta De Filippo, Prashiela Manga, Anke C Schiedel. Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism. Investigative ophthalmology & visual science. 2017 06; 58(7):3118-3126. doi: 10.1167/iovs.16-21128. [PMID: 28632878]
Bingfang Hu, Yujin Li, Li Gao, Yan Guo, Yiwen Zhang, Xiaojuan Chai, Meishu Xu, Jiong Yan, Peipei Lu, Songrong Ren, Su Zeng, Yulan Liu, Wen Xie, Min Huang. Hepatic Induction of Fatty Acid Binding Protein 4 Plays a Pathogenic Role in Sepsis in Mice. The American journal of pathology. 2017 May; 187(5):1059-1067. doi: 10.1016/j.ajpath.2017.01.002. [PMID: 28279656]
Jun Katagi, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Atsushi Honda, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama. Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K(+) Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model. Cardiovascular toxicology. 2016 Apr; 16(2):138-46. doi: 10.1007/s12012-015-9322-2. [PMID: 25822712]
Karen van der Weide, Jan van der Weide. The Influence of the CYP3A4*22 Polymorphism and CYP2D6 Polymorphisms on Serum Concentrations of Aripiprazole, Haloperidol, Pimozide, and Risperidone in Psychiatric Patients. Journal of clinical psychopharmacology. 2015 Jun; 35(3):228-36. doi: 10.1097/jcp.0000000000000319. [PMID: 25868121]
Marta M Wells, Tommy S Tillman, David D Mowrey, Tianmo Sun, Yan Xu, Pei Tang. Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain. Journal of medicinal chemistry. 2015 Apr; 58(7):2958-2966. doi: 10.1021/jm501873p. [PMID: 25790278]
Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Dec; 136(2):581-94. doi: 10.1093/toxsci/kft205. [PMID: 24052561]
Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
Hobart L Rogers, Atul Bhattaram, Issam Zineh, Jogarao Gobburu, Mitchell Mathis, Thomas P Laughren, Michael Pacanowski. CYP2D6 genotype information to guide pimozide treatment in adult and pediatric patients: basis for the U.S. Food and Drug Administration's new dosing recommendations. The Journal of clinical psychiatry. 2012 Sep; 73(9):1187-90. doi: 10.4088/jcp.11m07572. [PMID: 23059146]
S M Sharaf. Effect of GnRHa, pimozide and Ovaprim on ovulation and plasma sex steroid hormones in African catfish Clarias gariepinus. Theriogenology. 2012 May; 77(8):1709-16. doi: 10.1016/j.theriogenology.2011.12.019. [PMID: 22365698]
Luis A Zarazaga, Irma Celi, José Luis Guzmán, Benoît Malpaux. The effect of nutrition on the neural mechanisms potentially involved in melatonin-stimulated LH secretion in female Mediterranean goats. The Journal of endocrinology. 2011 Dec; 211(3):263-72. doi: 10.1530/joe-11-0225. [PMID: 21903864]
Francesca R Buttarelli, Alessandra Fanciulli, Clelia Pellicano, Francesco E Pontieri. The dopaminergic system in peripheral blood lymphocytes: from physiology to pharmacology and potential applications to neuropsychiatric disorders. Current neuropharmacology. 2011 Jun; 9(2):278-88. doi: 10.2174/157015911795596612. [PMID: 22131937]
Liansheng Liu, Qian Li, Robert Sapolsky, Min Liao, Kshama Mehta, Aditi Bhargava, Pankaj J Pasricha. Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults. PloS one. 2011 May; 6(5):e19498. doi: 10.1371/journal.pone.0019498. [PMID: 21589865]
Luis A Zarazaga, Irma Celi, José Luis Guzmán, Benoît Malpaux. The role of nutrition in the regulation of luteinizing hormone secretion by the opioidergic, dopaminergic, and serotonergic systems in female Mediterranean goats. Biology of reproduction. 2011 Mar; 84(3):447-54. doi: 10.1095/biolreprod.110.086520. [PMID: 20980689]
José M Guzmán, Rosa Cal, Angel García-López, Olvido Chereguini, Katherine Kight, Mercedes Olmedo, Carmen Sarasquete, Constantinos C Mylonas, José B Peleteiro, Yonathan Zohar, Evaristo L Mañanós. Effects of in vivo treatment with the dopamine antagonist pimozide and gonadotropin-releasing hormone agonist (GnRHa) on the reproductive axis of Senegalese sole (Solea senegalensis). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2011 Feb; 158(2):235-45. doi: 10.1016/j.cbpa.2010.11.016. [PMID: 21112410]
Bindu M Boddupalli, Zulkar N K Mohammed, Ravinder A Nath, David Banji. Mucoadhesive drug delivery system: An overview. Journal of advanced pharmaceutical technology & research. 2010 Oct; 1(4):381-7. doi: 10.4103/0110-5558.76436. [PMID: 22247877]
Ming-Hong Hsieh, Wei-Wen Lin, Shao-Tsu Chen, Kao-Ching Chen, Kuang-Peng Chen, Nan-Ying Chiu, Chao Huang, Ching-Jui Chang, Cheng-Hsiu Lin, Te-Jen Lai. A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting. Annals of general psychiatry. 2010 Sep; 9(?):35. doi: 10.1186/1744-859x-9-35. [PMID: 20849577]
Arjan P Palstra, Guido E E J M van den Thillart. Swimming physiology of European silver eels (Anguilla anguilla L.): energetic costs and effects on sexual maturation and reproduction. Fish physiology and biochemistry. 2010 Sep; 36(3):297-322. doi: 10.1007/s10695-010-9397-4. [PMID: 20390348]
Miao Yan, Huan-De Li, Ben-Mei Chen, Xiao-Lei Liu, Ping Xu, Yun-Gui Zhu. Quantitative determination of pimozide in human plasma by liquid chromatography-mass spectrometry and its application in a bioequivalence study. Journal of pharmaceutical and biomedical analysis. 2010 Apr; 51(5):1161-4. doi: 10.1016/j.jpba.2009.11.015. [PMID: 19969437]
Beena Bhandari, Pankaj Bansal, Pankaj Talwar, Satish K Gupta. Delineation of downstream signalling components during acrosome reaction mediated by heat solubilized human zona pellucida. Reproductive biology and endocrinology : RB&E. 2010 Jan; 8(?):7. doi: 10.1186/1477-7827-8-7. [PMID: 20096131]
Arlan L Rosenbloom. Hyperprolactinemia with antipsychotic drugs in children and adolescents. International journal of pediatric endocrinology. 2010; 2010(?):. doi: 10.1155/2010/159402. [PMID: 20871665]
Franco Maggiolo. Efavirenz: a decade of clinical experience in the treatment of HIV. The Journal of antimicrobial chemotherapy. 2009 Nov; 64(5):910-28. doi: 10.1093/jac/dkp334. [PMID: 19767318]
Christian Gillet, Bernard Breton. LH secretion and ovulation following exposure of Arctic charr to different temperature and photoperiod regimes: responsiveness of females to a gonadotropin-releasing hormone analogue and a dopamine antagonist. General and comparative endocrinology. 2009 Jun; 162(2):210-8. doi: 10.1016/j.ygcen.2009.03.005. [PMID: 19303415]
Takeshi Kumazawa, Koichi Saeki, Isao Yanagisawa, Seisaku Uchigasaki, Chika Hasegawa, Hiroshi Seno, Osamu Suzuki, Keizo Sato. Automated on-line in-tube solid-phase microextraction coupled with HPLC/MS/MS for the determination of butyrophenone derivatives in human plasma. Analytical and bioanalytical chemistry. 2009 Jun; 394(4):1161-70. doi: 10.1007/s00216-009-2774-0. [PMID: 19387622]
Lídia Ordacgi, Mauro V Mendlowicz, Leonardo F Fontenelle. Management of obsessive-compulsive disorder with fluvoxamine extended release. Neuropsychiatric disease and treatment. 2009; 5(?):301-8. doi: 10.2147/ndt.s3301. [PMID: 19557140]
Barbara A Wible, Yuri A Kuryshev, Stephen S Smith, Zhiqi Liu, Arthur M Brown. An ion channel library for drug discovery and safety screening on automated platforms. Assay and drug development technologies. 2008 Dec; 6(6):765-80. doi: 10.1089/adt.2008.171. [PMID: 19090691]
Ramadhan Oruch, Erlend Hodneland, Ian F Pryme, Holm Holmsen. Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: a result of receptor-independent drug intercalation in the plasma membrane?. Biochimica et biophysica acta. 2008 Oct; 1778(10):2165-76. doi: 10.1016/j.bbamem.2008.04.007. [PMID: 18503745]
Elke Ericson, Marinella Gebbia, Lawrence E Heisler, Jan Wildenhain, Mike Tyers, Guri Giaever, Corey Nislow. Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast. PLoS genetics. 2008 Aug; 4(8):e1000151. doi: 10.1371/journal.pgen.1000151. [PMID: 18688276]
Roger J Sullivan, Edward H Hagen, Peter Hammerstein. Revealing the paradox of drug reward in human evolution. Proceedings. Biological sciences. 2008 Jun; 275(1640):1231-41. doi: 10.1098/rspb.2007.1673. [PMID: 18353749]
Sean G Brown, Michael Gallacher, Richard E Olver, Stuart M Wilson. The regulation of selective and nonselective Na+ conductances in H441 human airway epithelial cells. American journal of physiology. Lung cellular and molecular physiology. 2008 May; 294(5):L942-54. doi: 10.1152/ajplung.00240.2007. [PMID: 18310228]
Ian N Olver. Prevention of chemotherapy-induced nausea and vomiting: focus on fosaprepitant. Therapeutics and clinical risk management. 2008 Apr; 4(2):501-6. doi: 10.2147/tcrm.s2345. [PMID: 18728837]
Li Zhang, Zhang Li, Hua Yu, Yu Hua, Wen Ming Li, Li Wen Ming, Man Chun Cheung, Cheung Man Chun, Yuan Ping Pang, Pang Yuan Ping, Ge Lin, Lin Ge, Yi Tao Wang, Wang Yi Tao, Zhong Zuo, Zuo Zhong, Yi Fan Han, Han Yi Fan. Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2008 Apr; 22(4):414-20. doi: 10.1002/bmc.949. [PMID: 18059054]
Tzong-Cherng Chi, Yi-Jin Ho, Win-Pin Chen, Tsung-Li Chi, Shoei-Sheng Lee, Juei-Tang Cheng, Ming-Jai Su. Serotonin enhances beta-endorphin secretion to lower plasma glucose in streptozotocin-induced diabetic rats. Life sciences. 2007 Apr; 80(20):1832-8. doi: 10.1016/j.lfs.2007.02.016. [PMID: 17397876]
R J Aitken, E A McLaughlin. Molecular mechanisms of sperm capacitation: progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated state. Society of Reproduction and Fertility supplement. 2007; 63(?):273-93. doi: NULL. [PMID: 17566279]
H Kirchherr, W N Kühn-Velten. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Oct; 843(1):100-13. doi: 10.1016/j.jchromb.2006.05.031. [PMID: 16798119]
Christine Zalejski, Sophie Paradis, Régis Maldiney, Yvette Habricot, Emile Miginiac, Jean-Pierre Rona, Emmanuelle Jeannette. Induction of abscisic acid-regulated gene expression by diacylglycerol pyrophosphate involves Ca2+ and anion currents in Arabidopsis suspension cells. Plant physiology. 2006 Aug; 141(4):1555-62. doi: 10.1104/pp.106.080218. [PMID: 16766676]
Ming-Guo Feng, L Gabriel Navar. Nitric oxide synthase inhibition activates L- and T-type Ca2+ channels in afferent and efferent arterioles. American journal of physiology. Renal physiology. 2006 Apr; 290(4):F873-9. doi: 10.1152/ajprenal.00042.2005. [PMID: 16263803]
Frank M C Besag, David Berry. Interactions between antiepileptic and antipsychotic drugs. Drug safety. 2006; 29(2):95-118. doi: 10.2165/00002018-200629020-00001. [PMID: 16454538]
Boni Elewski, Amir Tavakkol. Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. Therapeutics and clinical risk management. 2005 Dec; 1(4):299-306. doi: . [PMID: 18360572]
Maria M Campos, Elizabeth S Fernandes, Juliano Ferreira, Adair R S Santos, João B Calixto. Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms. Psychopharmacology. 2005 Oct; 182(1):45-53. doi: 10.1007/s00213-005-0052-1. [PMID: 15991001]
Motohiro Shiotani, Takuma Harada, Junko Abe, Yasufusa Sawada, Keitaro Hashimoto, Yoshimasa Hamada, Ikuo Horii. Practical application of guinea pig telemetry system for QT evaluation. The Journal of toxicological sciences. 2005 Aug; 30(3):239-47. doi: 10.2131/jts.30.239. [PMID: 16141657]
Jeffrey Alderman. Coadministration of sertraline with cisapride or pimozide: an open-label, nonrandomized examination of pharmacokinetics and corrected QT intervals in healthy adult volunteers. Clinical therapeutics. 2005 Jul; 27(7):1050-63. doi: 10.1016/j.clinthera.2005.07.013. [PMID: 16154484]
Shigeki Toyoshima, Akihiro Kanno, Tetsuya Kitayama, Koji Sekiya, Keiko Nakai, Masao Haruna, Terumasa Mino, Hiroyasu Miyazaki, Koji Yano, Keiji Yamamoto. QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals. Journal of pharmacological sciences. 2005; 99(5):459-71. doi: 10.1254/jphs.qt-a2. [PMID: 16493187]
Ming-Guo Feng, L Gabriel Navar. Angiotensin II-mediated constriction of afferent and efferent arterioles involves T-type Ca2+ channel activation. American journal of nephrology. 2004 Nov; 24(6):641-8. doi: 10.1159/000082946. [PMID: 15627720]
Bernadette Vidal, Catherine Pasqualini, Nadine Le Belle, M Claire H Holland, Miskal Sbaihi, Philippe Vernier, Yonathan Zohar, Sylvie Dufour. Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty. Biology of reproduction. 2004 Nov; 71(5):1491-500. doi: 10.1095/biolreprod.104.030627. [PMID: 15229141]
S G O'Brien, P Meinhardt, E Bond, J Beck, B Peng, C Dutreix, G Mehring, S Milosavljev, C Huber, R Capdeville, T Fischer. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. British journal of cancer. 2003 Nov; 89(10):1855-9. doi: 10.1038/sj.bjc.6601152. [PMID: 14612892]
Carsten Kratzsch, Frank T Peters, Thomas Kraemer, Armin A Weber, Hans H Maurer. Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization. Journal of mass spectrometry : JMS. 2003 Mar; 38(3):283-95. doi: 10.1002/jms.440. [PMID: 12644990]
Risto S Cvetkovic, Karen L Goa. Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs. 2003; 63(8):769-802. doi: 10.2165/00003495-200363080-00004. [PMID: 12662125]
Lori Shapiro, Sandra Knowles, Neil Shear. Drug interactions of clinical significance for the dermatologist: recognition and avoidance. American journal of clinical dermatology. 2003; 4(9):623-39. doi: 10.2165/00128071-200304090-00005. [PMID: 12926981]
M Claire H Holland, Shimon Hassin, Yonathan Zohar. The effects of long-term testosterone, gonadotropin-releasing hormone agonist and pimozide treatments on testicular development and luteinizing hormone levels in juvenile and early maturing striped bass, Morone saxatilis. General and comparative endocrinology. 2002 Dec; 129(3):178-87. doi: 10.1016/s0016-6480(02)00532-4. [PMID: 12460602]
T Baptista, N M K N Y Kin, S Beaulieu, E A de Baptista. Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives. Pharmacopsychiatry. 2002 Nov; 35(6):205-19. doi: 10.1055/s-2002-36391. [PMID: 12518268]
Zoltán Macháty, Jagdeece J Ramsoondar, Aaron J Bonk, Randall S Prather, Kenneth R Bondioli. Na(+)/Ca(2+) exchanger in porcine oocytes. Biology of reproduction. 2002 Oct; 67(4):1133-9. doi: 10.1095/biolreprod67.4.1133. [PMID: 12297528]
Sathapana Kongsamut, Jiesheng Kang, Xiao-Liang Chen, Joachim Roehr, David Rampe. A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs. European journal of pharmacology. 2002 Aug; 450(1):37-41. doi: 10.1016/s0014-2999(02)02074-5. [PMID: 12176106]
Miroslawa Sokolowska-Mikolajczyk, Magdalena Socha, Tomasz Mikolajczyk, Jaroslaw Chyb, Piotr Epler. The effects of naltrexone, an opioid receptor antagonist, on plasma LH levels in common carp (Cyprinus carpio L.). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2002 Apr; 131(4):417-24. doi: 10.1016/s1532-0456(02)00024-8. [PMID: 11976056]
Zeruesenay Desta, Nadia Soukhova, David A Flockhart. In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors and azithromycin. Journal of clinical psychopharmacology. 2002 Apr; 22(2):162-8. doi: 10.1097/00004714-200204000-00009. [PMID: 11910261]
Philip Seeman. Atypical antipsychotics: mechanism of action. Canadian journal of psychiatry. Revue canadienne de psychiatrie. 2002 Feb; 47(1):27-38. doi: . [PMID: 11873706]
Celia M Santi, Francisco S Cayabyab, Kathy G Sutton, John E McRory, Janette Mezeyova, Kevin S Hamming, David Parker, Anthony Stea, Terrance P Snutch. Differential inhibition of T-type calcium channels by neuroleptics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Jan; 22(2):396-403. doi: 10.1523/jneurosci.22-02-00396.2002. [PMID: 11784784]
P J Kemp, K J Kim, Z Borok, E D Crandall. Re-evaluating the Na(+) conductance of adult rat alveolar type II pneumocytes: evidence for the involvement of cGMP-activated cation channels. The Journal of physiology. 2001 Nov; 536(Pt 3):693-701. doi: 10.1111/j.1469-7793.2001.t01-1-00693.x. [PMID: 11691865]
K Finlayson, L Turnbull, C T January, J Sharkey, J S Kelly. [3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen. European journal of pharmacology. 2001 Oct; 430(1):147-8. doi: 10.1016/s0014-2999(01)01362-0. [PMID: 11698075]
B Drolet, G Rousseau, P Daleau, R Cardinal, C Simard, J Turgeon. Pimozide (Orap) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current in native cardiac myocytes. Journal of cardiovascular pharmacology and therapeutics. 2001 Jul; 6(3):255-60. doi: 10.1177/107424840100600306. [PMID: 11584332]
L N Greenwood, A P Scott, E L Vermeirssen, C C Mylonas, M Pavlidis. Plasma steroids in mature common dentex (Dentex dentex) stimulated with a gonadotropin-releasing hormone agonist. General and comparative endocrinology. 2001 Jul; 123(1):1-12. doi: 10.1006/gcen.2000.7519. [PMID: 11551110]
R Lang, G Lee, W Liu, S Tian, H Rafi, M Orias, A S Segal, G V Desir. KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. American journal of physiology. Renal physiology. 2000 Jun; 278(6):F1013-21. doi: 10.1152/ajprenal.2000.278.6.f1013. [PMID: 10836990]
C Patrat, C Serres, P Jouannet. Induction of a sodium ion influx by progesterone in human spermatozoa. Biology of reproduction. 2000 May; 62(5):1380-6. doi: 10.1095/biolreprod62.5.1380. [PMID: 10775190]
M Tatsumi, K Jansen, R D Blakely, E Richelson. Pharmacological profile of neuroleptics at human monoamine transporters. European journal of pharmacology. 1999 Mar; 368(2-3):277-83. doi: 10.1016/s0014-2999(99)00005-9. [PMID: 10193665]
T Yazawa, K Yamamoto, S Kikuyama, S I Abé. Elevation of plasma prolactin concentrations by low temperature is the cause of spermatogonial cell death in the newt, Cynops pyrrhogaster. General and comparative endocrinology. 1999 Feb; 113(2):302-11. doi: 10.1006/gcen.1998.7207. [PMID: 10082633]
Z Desta, T Kerbusch, D A Flockhart. Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6). Clinical pharmacology and therapeutics. 1999 Jan; 65(1):10-20. doi: 10.1016/s0009-9236(99)70117-7. [PMID: 9951426]
M C Holland, S Hassin, Y Zohar. Effects of long-term testosterone, gonadotropin-releasing hormone agonist, and pimozide treatments on gonadotropin II levels and ovarian development in juvenile female striped bass (Morone saxatilis). Biology of reproduction. 1998 Nov; 59(5):1153-62. doi: 10.1095/biolreprod59.5.1153. [PMID: 9780322]
B Breton, M Govoroun, T Mikolajczyk. GTH I and GTH II secretion profiles during the reproductive cycle in female rainbow trout: relationship with pituitary responsiveness to GnRH-A stimulation. General and comparative endocrinology. 1998 Jul; 111(1):38-50. doi: 10.1006/gcen.1998.7088. [PMID: 9653020]
L Li, J A Schafer. Dopamine inhibits vasopressin-dependent cAMP production in the rat cortical collecting duct. The American journal of physiology. 1998 07; 275(1):F62-7. doi: 10.1152/ajprenal.1998.275.1.f62. [PMID: 9689005]
J Samochowiec, Z Kleinrok, E Jagiełło-Wójtowicz, J Horodnicki, H Rommelspacher, L G Schmidt. Effects of dopaminergic agonists and antagonists on the serum prolactin levels in alcoholized rats. Polish journal of pharmacology. 1997 Aug; 49(4):221-7. doi: NULL. [PMID: 9437765]
Z Suo, C Fang, F Crawford, M Mullan. Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity. Brain research. 1997 Jul; 762(1-2):144-52. doi: 10.1016/s0006-8993(97)00383-1. [PMID: 9262168]
T Kerbusch, Z Desta, N V Soukhova, D Thacker, D A Flockhart. Sensitive assay for pimozide in human plasma using high-performance liquid chromatography with fluorescence detection: application to pharmacokinetic studies. Journal of chromatography. B, Biomedical sciences and applications. 1997 Jun; 694(1):163-8. doi: 10.1016/s0378-4347(97)00152-7. [PMID: 9234859]
R K Chandolia, A C Evans, N C Rawlings. The involvement of dopaminergic and opioidergic neuronal systems in the control of the early rise in LH secretion in bull calves. Journal of neuroendocrinology. 1997 Feb; 9(2):121-7. doi: 10.1046/j.1365-2826.1997.00306.x. [PMID: 9041365]
J C Branum, R S Kline, C S Whisnant. The effects of neurotransmitter antagonists and glucose on luteinizing hormone secretion in growth-restricted wethers. Animal reproduction science. 1997 Jan; 45(4):263-72. doi: 10.1016/s0378-4320(96)01592-8. [PMID: 9231237]
E S Bondarenko, E A Iur'eva, V P Zykov, N V Alekseeva. [The laser therapy of children with Tourette's syndrome]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 1997; 97(1):29-32. doi: ". [PMID: 9163245]
F R Sallee, D Dougherty, G Sethuraman, N Vrindavanam. Prolactin monitoring of haloperidol and pimozide treatment in children with Tourette's syndrome. Biological psychiatry. 1996 Nov; 40(10):1044-50. doi: 10.1016/0006-3223(95)00596-x. [PMID: 8915564]
M J Rocha, M A Reis-Henriques. Plasma and urine levels of C18, C19 and C21 steroids in an asynchronous fish, the tilapia Oreochromis mossambicus (Teleostei, Cichlidae). Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. 1996 Nov; 115(3):257-64. doi: 10.1016/s0742-8413(96)00133-8. [PMID: 9375364]
S Kentroti, S M McCann. Role of dopamine in the inhibitory control of growth hormone and prolactin release by gastrin-releasing peptide. Brain research bulletin. 1996; 39(4):201-4. doi: 10.1016/0361-9230(95)02114-0. [PMID: 8963684]
R Díaz-Barberán, H Y Guerrero, R Manrique, D Marcano. Changes in plasma levels of 17 beta-estradiol after administration of an analogue of luteinizing hormone releasing hormone (LHRH-A) and pimozide in Diplectrum formosum (Teleostei: Serranidae). General and comparative endocrinology. 1994 Nov; 96(2):172-8. doi: 10.1006/gcen.1994.1171. [PMID: 7851716]
D Golan, A Aharoni, U Halbreich. Prolactin response to electroconvulsive shock in anesthetized rats. Journal of psychiatric research. 1993 Jul; 27(3):235-40. doi: 10.1016/0022-3956(93)90033-x. [PMID: 8295155]
A B Sarmento, M C de Lima, C R Oliveira. Partition of dopamine antagonists into synthetic lipid bilayers: the effect of membrane structure and composition. The Journal of pharmacy and pharmacology. 1993 Jul; 45(7):601-5. doi: 10.1111/j.2042-7158.1993.tb05660.x. [PMID: 8105052]
G D Nicol. The calcium channel antagonist, pimozide, blocks the cyclic GMP-activated current in rod photoreceptors. The Journal of pharmacology and experimental therapeutics. 1993 May; 265(2):626-32. doi: NULL. [PMID: 8388454]
Z Sarnyai, E Bíró, G Telegdy. Cocaine-induced elevation of plasma corticosterone is mediated by different neurotransmitter systems in rats. Pharmacology, biochemistry, and behavior. 1993 May; 45(1):209-14. doi: 10.1016/0091-3057(93)90106-4. [PMID: 8100073]
S Le Corre, P Chemineau. Control of photoperiodic inhibition of luteinizing hormone secretion by dopaminergic and serotonergic systems in ovariectomized Ile-de-France ewes supplemented with oestradiol. Journal of reproduction and fertility. 1993 Mar; 97(2):367-73. doi: 10.1530/jrf.0.0970367. [PMID: 8501707]
S Minucci, S Fasano, M D'Antonio, R Pierantoni. Dopamine regulation of testicular activity in intact and hypophysectomized frogs, Rana esculenta. Experientia. 1993 Jan; 49(1):65-7. doi: 10.1007/bf01928792. [PMID: 8428613]
T Higuchi, K Honda, S Takano, H Negoro. Abolition of prolactin surge induced by ovarian steroid hormones in the lactating rat. Neuroendocrinology. 1992 Aug; 56(2):234-9. doi: 10.1159/000126233. [PMID: 1407378]
F R Sallee, U Kopp, I Hanin. Controlled study of erythrocyte choline in Tourette syndrome. Biological psychiatry. 1992 Jun; 31(12):1204-12. doi: 10.1016/0006-3223(92)90339-2. [PMID: 1391281]
C M Palmeira, C R Oliveira. Partitioning and membrane disordering effects of dopamine antagonists: influence of lipid peroxidation, temperature, and drug concentration. Archives of biochemistry and biophysics. 1992 May; 295(1):161-71. doi: 10.1016/0003-9861(92)90502-n. [PMID: 1575512]
M Cokelaere, E R Kühn. Influence of pimozide on a TRH induced TSH secretion in the rat during food deprivation. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1992 Feb; 24(2):53-5. doi: 10.1055/s-2007-1003254. [PMID: 1572595]
L L Badura, B D Goldman. Prolactin-dependent seasonal changes in pelage: role of the pineal gland and dopamine. The Journal of experimental zoology. 1992 Jan; 261(1):27-33. doi: 10.1002/jez.1402610105. [PMID: 1729383]
Z Sarnyai, M Vecsernyés, J Julesz, G Szabó, G Telegdy. Effects of cocaine and pimozide on plasma and brain alpha-melanocyte-stimulating hormone levels in rats. Neuroendocrinology. 1992 Jan; 55(1):9-13. doi: 10.1159/000126090. [PMID: 1319008]
J Zhang, B H Yuen, W D Currie, P C Leung. Suppression of luteinizing hormone secretion by atrial and brain natriuretic peptides in ovariectomized rats. Endocrinology. 1991 Aug; 129(2):801-6. doi: 10.1210/endo-129-2-801. [PMID: 1830270]