Maprotiline (BioDeep_00000002020)

 

Secondary id: BioDeep_00000405891

human metabolite blood metabolite


代谢物信息卡片


methyl(3-{tetracyclo[6.6.2.0²,⁷.0⁹,¹⁴]hexadeca-2,4,6,9,11,13-hexaen-1-yl}propyl)amine

化学式: C20H23N (277.183)
中文名称: 马普替林
谱图信息: 最多检出来源 Homo sapiens(plant) 31.7%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Maprotiline. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/maprotiline (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000002020). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CNCCCC12CCC(C3=C1C=CC=C3)C1=C2C=CC=C1
InChI: InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3

描述信息

Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
CONFIDENCE standard compound; INTERNAL_ID 835; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8225; ORIGINAL_PRECURSOR_SCAN_NO 8223
CONFIDENCE standard compound; INTERNAL_ID 835; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8170; ORIGINAL_PRECURSOR_SCAN_NO 8168
CONFIDENCE standard compound; INTERNAL_ID 835; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8212; ORIGINAL_PRECURSOR_SCAN_NO 8209
CONFIDENCE standard compound; INTERNAL_ID 835; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8187; ORIGINAL_PRECURSOR_SCAN_NO 8185
CONFIDENCE standard compound; INTERNAL_ID 835; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8233; ORIGINAL_PRECURSOR_SCAN_NO 8231
CONFIDENCE standard compound; INTERNAL_ID 835; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8247; ORIGINAL_PRECURSOR_SCAN_NO 8245
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3317
CONFIDENCE standard compound; INTERNAL_ID 2221
D049990 - Membrane Transport Modulators

同义名列表

37 个代谢物同义名

methyl(3-{tetracyclo[6.6.2.0²,⁷.0⁹,¹⁴]hexadeca-2,4,6,9,11,13-hexaen-1-yl}propyl)amine; CT-Arzneimittel brand OF maprotiline hydrochloride; N-Methyl-9,10-ethanoanthracene-9(10H)-propylamine; Neuraxpharm brand OF maprotiline hydrochloride; Ratiopharm brand OF maprotiline hydrochloride; Novopharm brand OF maprotiline hydrochloride; Dolorgiet brand OF maprotiline hydrochloride; Novartis brand OF maprotiline hydrochloride; Declimed brand OF maprotiline hydrochloride; Lundbeck brand OF maprotiline hydrochloride; Holsten brand OF maprotiline hydrochloride; Teva brand OF maprotiline hydrochloride; Hexal brand OF maprotiline mesylate; Hydrochloride, maprotiline; Maprotiline Hydrochloride; Maprotilin-neuraxpharm; Maprotilin neuraxpharm; Maprotilin ratiopharm; Maprotilin-ratiopharm; Mesylate, maprotiline; Maprotiline mesylate; Maprotilin holsten; Maprotilin von CT; Novo-maprotiline; Novo maprotiline; Maprotilin-teva; Maprotilin teva; Dibencycladine; maprotiline; Maprotilin; Deprilept; BA-34276; Ludiomil; Psymion; Maprolu; Mirpan; Maprotiline



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AXIN2, BDNF, CYP2C19, CYP2D6, PTGS2, SLC6A3, TH
Peripheral membrane protein 1 PTGS2
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 4 CYP1A2, CYP2C19, CYP2D6, PTGS2
Mitochondrion membrane 1 MAOA
Nucleus 3 AXIN2, PLCZ1, TH
cytosol 4 AXIN2, MAOA, PLCZ1, TH
dendrite 4 BDNF, DRD2, HTR1A, TH
centrosome 1 AXIN2
nucleoplasm 2 PLCZ1, SCNN1G
Cell membrane 8 DRD2, HTR1A, HTR3A, KCNH2, SLC6A2, SLC6A3, SLC6A4, TNF
Cytoplasmic side 1 MAOA
Cleavage furrow 1 HTR3A
Cell projection, axon 2 SLC6A3, TH
Multi-pass membrane protein 8 DRD2, HTR1A, HTR3A, KCNH2, SCNN1G, SLC6A2, SLC6A3, SLC6A4
Golgi apparatus membrane 1 DRD2
Synapse 4 DRD2, HTR1A, HTR3A, SLC6A4
cell surface 4 KCNH2, SLC6A2, SLC6A3, TNF
glutamatergic synapse 1 DRD2
Golgi membrane 2 DRD2, INS
neuronal cell body 2 SLC6A3, TNF
postsynapse 1 HTR3A
presynaptic membrane 4 DRD2, SLC6A2, SLC6A3, SLC6A4
smooth endoplasmic reticulum 1 TH
synaptic vesicle 2 BDNF, TH
Presynapse 1 SLC6A4
acrosomal vesicle 1 DRD2
plasma membrane 11 AXIN2, CYP2C19, DRD2, HTR1A, HTR3A, KCNH2, SCNN1G, SLC6A2, SLC6A3, SLC6A4, TNF
synaptic vesicle membrane 2 DRD2, SLC6A2
terminal bouton 1 TH
Membrane 8 BDNF, CYP2D6, HTR3A, KCNH2, MAOA, SLC6A2, SLC6A3, SLC6A4
apical plasma membrane 1 SCNN1G
axon 5 BDNF, DRD2, SLC6A2, SLC6A3, TH
caveola 1 PTGS2
extracellular exosome 1 SCNN1G
endoplasmic reticulum 2 CYP2D6, PTGS2
extracellular space 3 BDNF, INS, TNF
perinuclear region of cytoplasm 4 BDNF, KCNH2, PLCZ1, TH
mitochondrion 3 CYP2D6, MAOA, TH
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 3 CYP1A2, CYP2C19, CYP2D6
Microsome membrane 3 CYP1A2, CYP2D6, PTGS2
pronucleus 1 PLCZ1
Secreted 3 BDNF, INS, TRH
extracellular region 4 BDNF, INS, TNF, TRH
cytoplasmic side of plasma membrane 1 TH
Mitochondrion outer membrane 1 MAOA
Single-pass membrane protein 2 CYP2D6, MAOA
mitochondrial outer membrane 1 MAOA
neuronal cell body membrane 2 SLC6A2, SLC6A3
ciliary membrane 1 DRD2
external side of plasma membrane 2 SCNN1G, TNF
dendritic spine 1 DRD2
perikaryon 2 DRD2, TH
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 TH
nucleolus 1 PLCZ1
Melanosome membrane 1 TH
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 4 DRD2, HTR3A, SLC6A3, SLC6A4
Apical cell membrane 1 SCNN1G
Cytoplasm, perinuclear region 2 PLCZ1, TH
Membrane raft 3 SLC6A3, SLC6A4, TNF
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 1 SLC6A4
GABA-ergic synapse 1 DRD2
flotillin complex 1 SLC6A3
secretory granule 1 TRH
lateral plasma membrane 1 DRD2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 HTR3A
Cell projection, neuron projection 2 SLC6A3, SLC6A4
neuron projection 5 HTR3A, PTGS2, SLC6A3, SLC6A4, TH
cilium 1 DRD2
phagocytic cup 1 TNF
non-motile cilium 1 DRD2
serotonin-activated cation-selective channel complex 1 HTR3A
transmembrane transporter complex 1 HTR3A
sperm flagellum 1 DRD2
Endomembrane system 1 SLC6A4
endosome lumen 1 INS
monoatomic ion channel complex 1 KCNH2
sodium channel complex 1 SCNN1G
Cell projection, dendrite 1 HTR1A
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 1 KCNH2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BDNF, INS, PTGS2
axon terminus 2 DRD2, SLC6A3
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 MAOA
dopaminergic synapse 2 DRD2, SLC6A3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
sperm head 1 PLCZ1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
G protein-coupled receptor complex 1 DRD2
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
serotonergic synapse 1 SLC6A4
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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