2-Deoxy-L-ribono-1,4-lactone (BioDeep_00000019514)

 

Secondary id: BioDeep_00000004971, BioDeep_00000269243

human metabolite


代谢物信息卡片


(4S,5R)-4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one

化学式: C5H8O4 (132.0423)
中文名称: D-(+)-核糖酸-γ-内酯
谱图信息: 最多检出来源 Viridiplantae(plant) 14.65%

分子结构信息

SMILES: C1C(C(OC1=O)CO)O
InChI: InChI=1S/C5H8O4/c6-2-4-3(7)1-5(8)9-4/h3-4,6-7H,1-2H2

描述信息

2-Deoxy-L-ribono-1,4-lactone is found in herbs and spices. 2-Deoxy-L-ribono-1,4-lactone is a constituent of the fruit of Foeniculum vulgare (fennel).
Constituent of the fruit of Foeniculum vulgare (fennel). 2-Deoxy-L-ribono-1,4-lactone is found in herbs and spices.

同义名列表

6 个代谢物同义名

(4S,5R)-4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one; 4,5-dihydro-4-Hydroxy-5-(hydroxymethyl)-2(3H)-furanone; 4-hydroxy-5-(hydroxymethyl)oxolan-2-one; 2-Deoxy-D-ribono-1,4-lactone; 2-deoxy-l-ribono-1,4-lactone; L-erythro-Form



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 NEIL1, POLB, TNFSF14
Peripheral membrane protein 1 ACHE
Nucleus 18 ACHE, EXOG, FEN1, H2AX, LIG1, LIG4, MUTYH, NEIL1, NEIL3, OGG1, PARP1, PCNA, POLB, POLL, POLM, POLQ, REV1, UNG
cytosol 4 NEIL1, OGG1, PARP1, POLQ
nuclear body 2 PARP1, PCNA
centrosome 3 H2AX, NEIL1, PCNA
nucleoplasm 16 FEN1, H2AX, LIG1, LIG4, MUTYH, NEIL1, NEIL3, OGG1, PARP1, PCNA, POLB, POLL, POLM, POLQ, REV1, UNG
Cell membrane 2 ACHE, LIG1
Synapse 1 ACHE
cell surface 1 ACHE
Golgi apparatus 2 ACHE, POLQ
Golgi membrane 1 INS
mitochondrial inner membrane 1 EXOG
neuromuscular junction 1 ACHE
Cytoplasm, cytosol 1 PARP1
plasma membrane 3 ACHE, LIG1, TNFSF14
Membrane 4 ACHE, EXOG, FEN1, PARP1
extracellular exosome 2 H2AX, PCNA
extracellular space 4 ACHE, INS, LIG1, TNFSF14
perinuclear region of cytoplasm 1 ACHE
mitochondrion 7 EXOG, FEN1, LIG1, MUTYH, OGG1, PARP1, UNG
protein-containing complex 5 EXOG, FEN1, OGG1, PARP1, POLB
intracellular membrane-bounded organelle 2 LIG1, LIG4
Single-pass type I membrane protein 1 LIG1
Secreted 2 ACHE, INS
extracellular region 2 ACHE, INS
mitochondrial matrix 1 OGG1
Extracellular side 1 ACHE
transcription regulator complex 1 PARP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NEIL1
nucleolus 2 FEN1, PARP1
Mitochondrion inner membrane 1 EXOG
microtubule 1 POLB
extracellular matrix 1 LIG1
mitochondrial nucleoid 1 POLQ
basement membrane 1 ACHE
nuclear speck 2 H2AX, OGG1
chromatin 2 PARP1, PCNA
Chromosome 6 H2AX, NEIL1, NEIL3, PARP1, POLL, POLQ
Nucleus, nucleolus 2 FEN1, PARP1
nuclear replication fork 2 PARP1, PCNA
chromosome, telomeric region 4 FEN1, LIG4, PARP1, PCNA
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 4 H2AX, PARP1, POLL, POLQ
nuclear envelope 1 PARP1
endosome lumen 1 INS
Nucleus, nucleoplasm 2 FEN1, OGG1
Nucleus speckle 1 OGG1
side of membrane 1 ACHE
replication fork 2 H2AX, PCNA
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 OGG1
male germ cell nucleus 2 H2AX, PCNA
XY body 1 H2AX
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Nucleus matrix 1 OGG1
condensed nuclear chromosome 1 H2AX
nuclear lamina 1 PCNA
synaptic cleft 1 ACHE
protein-DNA complex 1 PARP1
spindle microtubule 1 POLB
nucleosome 1 H2AX
condensed chromosome 1 LIG4
site of DNA damage 3 H2AX, PARP1, POLQ
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
DNA-dependent protein kinase-DNA ligase 4 complex 1 LIG4
nonhomologous end joining complex 1 LIG4
[Isoform H]: Cell membrane 1 ACHE
[Isoform FENMIT]: Mitochondrion 1 FEN1
DNA ligase IV complex 1 LIG4


文献列表

  • Shaheen Faizi, Najma Rasool Mughal, Rashid Ali Khan, Shakeel Ahmed Khan, Aqeel Ahmad, Nazia Bibi, Shaheena Anwar Ahmed. Evaluation of the antimicrobial property of Polyalthia longifolia var. pendula: isolation of a lactone as the active antibacterial agent from the ethanol extract of the stem. Phytotherapy research : PTR. 2003 Dec; 17(10):1177-81. doi: 10.1002/ptr.1333. [PMID: 14669252]
  • Yutaka Oomura, Shuji Aou, Ikuo Matsumoto, Toshiie Sakata. Physiological significance of 2-buten-4-olide (2-B4O), an endogenous satiety substance increased in the fasted state. Experimental biology and medicine (Maywood, N.J.). 2003 Nov; 228(10):1146-55. doi: 10.1177/153537020322801008. [PMID: 14610253]
  • M He, J H Zhang, C Q Hu. [Studies on the chemical components of Clematis chinensis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2001 Apr; 36(4):278-80. doi: ". [PMID: 12580056]
  • T Sakata. Structural and stereoisomeric specificity of serum-borne sugar acids related to feeding control by rats. Brain research bulletin. 1990 Dec; 25(6):969-74. doi: 10.1016/0361-9230(90)90196-7. [PMID: 2289178]
  • S Nemoto. [Endogenous plasma concentration of gamma-lactone derivatives which modulate feeding behavior]. Fukuoka igaku zasshi = Hukuoka acta medica. 1988 Jan; 79(1):61-71. doi: NULL. [PMID: 3384386]