Valdecoxib (BioDeep_00000001946)
Secondary id: BioDeep_00000399170
human metabolite Endogenous Chemicals and Drugs
代谢物信息卡片
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide
化学式: C16H14N2O3S (314.0725)
中文名称: 伐地考昔
谱图信息:
最多检出来源 Escherichia coli(natural_products) 12.5%
分子结构信息
SMILES: CC1=C(C(=NO1)C1=CC=CC=C1)C1=CC=C(C=C1)S(N)(=O)=O
InChI: InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20)
描述信息
Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or NSAID, and should not be taken by anyone allergic to these types of medications. [HMDB]
Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or NSAID, and should not be taken by anyone allergic to these types of medications.
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AH - Coxibs
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D004791 - Enzyme Inhibitors > D016861 - Cyclooxygenase Inhibitors > D052246 - Cyclooxygenase 2 Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
同义名列表
13 个代谢物同义名
4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide; 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulphonamide; p-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulphonamide; 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; p-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide; Pfizer brand OF valdecoxib; Valdecoxibum; Valdecoxib; Valecoxib; Bextra; Valdyn; Kudeq; COX
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:63634
- KEGG: C21552
- KEGGdrug: D02709
- PubChem: 119607
- HMDB: HMDB0005033
- DrugBank: DB00580
- ChEMBL: CHEMBL865
- Wikipedia: Valdecoxib
- foodb: FDB023600
- chemspider: 106796
- CAS: 181695-72-7
- PMhub: MS000001518
- PubChem: 336445190
- PDB-CCD: COX
- RefMet: Valdecoxib
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Seung Yeon Park, Wonjun Cho, A M Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jung. Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress.
Biochemical pharmacology.
2022 05; 199(?):115022. doi:
10.1016/j.bcp.2022.115022. [PMID: 35358477] - Tae Jin Kim, Hyun Jung Lee, Do Hyeon Pyun, A M Abd El-Aty, Ji Hoon Jeong, Tae Woo Jung. Valdecoxib improves lipid-induced skeletal muscle insulin resistance via simultaneous suppression of inflammation and endoplasmic reticulum stress.
Biochemical pharmacology.
2021 06; 188(?):114557. doi:
10.1016/j.bcp.2021.114557. [PMID: 33844985] - Mengchun Chen, Wei Sun, Zhe Wang, Chengke Huang, Guoxin Hu, Yijie Chen, Ledan Wang. Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies.
BMC pharmacology & toxicology.
2020 04; 21(1):27. doi:
10.1186/s40360-020-00406-5. [PMID: 32264977] - Shuang-Long Li, Yong-Liang Zhu, Chun-Yang Zhu, Shao-Bin Li, Zi-Heng Li, Xiang-Jun Qiu. Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study.
Drug design, development and therapy.
2020; 14(?):1117-1125. doi:
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BioMed research international.
2020; 2020(?):1563874. doi:
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Inflammation.
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
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Anesthesiology.
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The American journal of emergency medicine.
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The Medical letter on drugs and therapeutics.
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