GW 7647 (BioDeep_00001876732)
Main id: BioDeep_00000010793
Volatile Flavor Compounds
代谢物信息卡片
2-[(4-{2-[(4-Cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid
化学式: C29H46N2O3S (502.32289660000004)
中文名称: 2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C(=O)O)SC1=CC=C(C=C1)CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3
InChI: InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)
描述信息
GW7647 is a potent PPARα agonist, with EC50s of 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ and PPARδ, respectively.
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:70778
- KEGG: C15622
- PubChem: 3392731
- ChEMBL: CHEMBL21241
- CAS: 265129-71-3
- PubChem: 17396612
- PDB-CCD: 2VN
- NIKKAJI: J1.537.419E
- medchemexpress: HY-13861
- KNApSAcK: 70778
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sylwia Żulińska, Anna K Strosznajder, Joanna B Strosznajder. The role of synthetic ligand of PPARα in regulation of transcription of genes related to mitochondria biogenesis and dynamic in an animal model of Alzheimer's disease.
Folia neuropathologica.
2023; 61(2):138-143. doi:
10.5114/fn.2023.129195. [PMID: 37587888] - Cigdem Sahin, Lilia Magomedova, Thais A M Ferreira, Jiabao Liu, Jens Tiefenbach, Priscilla S Alves, Fellipe J G Queiroz, Andressa S de Oliveira, Mousumi Bhattacharyya, Julie Grouleff, Patrícia C N Nogueira, Edilberto R Silveira, Daniel C Moreira, José Roberto Souza de Almeida Leite, Guilherme D Brand, David Uehling, Gennady Poda, Henry Krause, Carolyn L Cummins, Luiz A S Romeiro. Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases.
Journal of medicinal chemistry.
2022 02; 65(3):1961-1978. doi:
10.1021/acs.jmedchem.1c01542. [PMID: 35089724] - Zongtao Zhou, Qiang Ren, Shixuan Jiao, Zongyu Cai, Xinqian Geng, Liming Deng, Bin Wang, Lijun Hu, Luyong Zhang, Ying Yang, Zheng Li. Discovery of new and highly effective quadruple FFA1 and PPARα/γ/δ agonists as potential anti-fatty liver agents.
European journal of medicinal chemistry.
2022 Feb; 229(?):114061. doi:
10.1016/j.ejmech.2021.114061. [PMID: 34954593] - Xiao-Xia Qu, Jia-Huan He, Zhi-Qiang Cui, Tuo Yang, Xiao-Hong Sun. PPAR-α Agonist GW7647 Protects Against Oxidative Stress and Iron Deposit via GPx4 in a Transgenic Mouse Model of Alzheimer's Diseases.
ACS chemical neuroscience.
2022 01; 13(2):207-216. doi:
10.1021/acschemneuro.1c00516. [PMID: 34965724] - Donna D Yu, Gregg Van Citters, Hongzhi Li, Brian M Stoltz, Barry M Forman. Discovery of novel modulators for the PPARα (peroxisome proliferator activated receptor α): Potential therapies for nonalcoholic fatty liver disease.
Bioorganic & medicinal chemistry.
2021 07; 41(?):116193. doi:
10.1016/j.bmc.2021.116193. [PMID: 34022528] - Kai Liu, Xing Zhao, Xue Qi, Dong-Liang Hou, Hao-Bin Li, Yu-Hao Gu, Qing-Long Xu. Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms.
European journal of medicinal chemistry.
2021 Jun; 218(?):113388. doi:
10.1016/j.ejmech.2021.113388. [PMID: 33784603] - Franck Peiretti, Roberta Montanari, Davide Capelli, Bernadette Bonardo, Cécilia Colson, Ez-Zoubir Amri, Marina Grimaldi, Patrick Balaguer, Keiichi Ito, Robert G Roeder, Giorgio Pochetti, Jean Michel Brunel. A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities.
Journal of medicinal chemistry.
2020 11; 63(21):13124-13139. doi:
10.1021/acs.jmedchem.0c01555. [PMID: 33142057] - Jeayoung C Shin, Eunyoung Lee, Seungchan An, Sun Hee Jin, Jaehyoun Ha, Won Jun Choi, Minsoo Noh. Benzophenone-3 and benzophenone-8 exhibit obesogenic activity via peroxisome proliferator-activated receptor γ pathway.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Sep; 67(?):104886. doi:
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Bioorganic & medicinal chemistry.
2019 09; 27(18):4059-4068. doi:
10.1016/j.bmc.2019.07.032. [PMID: 31351846] - Hiroyuki Miyachi, Tomohiro Yuzuriha, Ryotaro Tabata, Syohei Fukuda, Kazuto Nunomura, Bangzhong Lin, Tadayuki Kobayashi, Kenji Ishimoto, Takefumi Doi, Keisuke Tachibana. Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists.
Bioorganic & medicinal chemistry letters.
2019 08; 29(16):2124-2128. doi:
10.1016/j.bmcl.2019.06.062. [PMID: 31320147] - Daniela Passeri, Andrea Carotti, Jose M Ramos Pittol, Gianmario Ciaccioli, Roberto Pellicciari, Saskia W C van Mil, Antimo Gioiello. Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool.
MedChemComm.
2019 Aug; 10(8):1412-1419. doi:
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Bioorganic & medicinal chemistry.
2019 07; 27(13):2948-2958. doi:
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Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2019 07; 25(7):1007-1022. doi:
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ACS medicinal chemistry letters.
2019 Apr; 10(4):545-551. doi:
10.1021/acsmedchemlett.8b00574. [PMID: 30996794] - Rahul Patil, Biswaranjan Mohanty, Bonan Liu, Indu R Chandrashekaran, Stephen J Headey, Martin L Williams, Craig S Clements, Olga Ilyichova, Bradley C Doak, Patrick Genissel, Richard J Weaver, Laurent Vuillard, Michelle L Halls, Christopher J H Porter, Martin J Scanlon. A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists.
The Journal of biological chemistry.
2019 03; 294(10):3720-3734. doi:
10.1074/jbc.ra118.006848. [PMID: 30598509] - Asmita Pant, Elizabeth A Rondini, Thomas A Kocarek. Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells.
Toxicology and applied pharmacology.
2019 02; 365(?):61-70. doi:
10.1016/j.taap.2019.01.003. [PMID: 30611723] - Leonore Wigger, Cristina Casals-Casas, Michaël Baruchet, Khanh B Trang, Sylvain Pradervand, Aurélien Naldi, Béatrice Desvergne. System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells.
PloS one.
2019; 14(8):e0220894. doi:
10.1371/journal.pone.0220894. [PMID: 31437187] - Anika Engel, Thorsten Buhrke, Stefanie Kasper, Anne-Cathrin Behr, Albert Braeuning, Sönke Jessel, Albrecht Seidel, Wolfgang Völkel, Alfonso Lampen. The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ.
Toxicology letters.
2018 May; 287(?):83-91. doi:
10.1016/j.toxlet.2018.02.006. [PMID: 29421333] - Jinha Yu, Seyeon Ahn, Hee Jin Kim, Moonyoung Lee, Sungjin Ahn, Jungmin Kim, Sun Hee Jin, Eunyoung Lee, Gyudong Kim, Jae Hoon Cheong, Kenneth A Jacobson, Lak Shin Jeong, Minsoo Noh. Polypharmacology of N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential.
Journal of medicinal chemistry.
2017 09; 60(17):7459-7475. doi:
10.1021/acs.jmedchem.7b00805. [PMID: 28799755] - Anika Engel, Thorsten Buhrke, Francine Imber, Sönke Jessel, Albrecht Seidel, Wolfgang Völkel, Alfonso Lampen. Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ERα, ERβ, and AR.
Toxicology letters.
2017 Aug; 277(?):54-63. doi:
10.1016/j.toxlet.2017.05.028. [PMID: 28571686] - Shogo Okazaki, Tomomi Noguchi-Yachide, Taki Sakai, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi. Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity.
Bioorganic & medicinal chemistry.
2016 11; 24(21):5258-5269. doi:
10.1016/j.bmc.2016.08.045. [PMID: 27591006] - Shogo Okazaki, Ryuta Shioi, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi. Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.
Bioorganic & medicinal chemistry.
2016 11; 24(21):5455-5461. doi:
10.1016/j.bmc.2016.08.067. [PMID: 27622746] - Paul N Black, Constance Ahowesso, David Montefusco, Nipun Saini, Concetta C DiRusso. Fatty Acid Transport Proteins: Targeting FATP2 as a Gatekeeper Involved in the Transport of Exogenous Fatty Acids.
MedChemComm.
2016 Apr; 7(4):612-622. doi:
10.1039/c6md00043f. [PMID: 27446528] - Anna Mattsson, Anna Kärrman, Rui Pinto, Björn Brunström. Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors.
PloS one.
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Bioorganic & medicinal chemistry letters.
2014 Jul; 24(14):3168-74. doi:
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Bioorganic & medicinal chemistry letters.
2014 Jul; 24(13):2957-62. doi:
10.1016/j.bmcl.2014.04.019. [PMID: 24821375] - Ewa Szalowska, Bart van der Burg, Hai-Yen Man, Peter J M Hendriksen, Ad A C M Peijnenburg. Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices.
PloS one.
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European heart journal.
2013 Aug; 34(32):2566-74. doi:
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2013 Feb; 56(4):1535-43. doi:
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The Journal of toxicological sciences.
2013; 38(2):305-8. doi:
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Environmental health perspectives.
2012 Dec; 120(12):1711-9. doi:
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European journal of medicinal chemistry.
2012 Dec; 58(?):317-22. doi:
10.1016/j.ejmech.2012.10.019. [PMID: 23137448] - Marie Strömqvist, Jan A Olsson, Anna Kärrman, Björn Brunström. Transcription of genes involved in fat metabolism in chicken embryos exposed to the peroxisome proliferator-activated receptor alpha (PPARα) agonist GW7647 or to perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA).
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2012 Jun; 156(1):29-36. doi:
10.1016/j.cbpc.2012.03.004. [PMID: 22465071] - Kathrin Weiss, Johanna Mihály, Gerhard Liebisch, Tamás Marosvölgyi, Gerd Schmitz, Tamás Decsi, Ralph Rühl. Effect of synthetic ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the fatty acid composition of phospholipids in mice.
Lipids.
2011 Nov; 46(11):1013-20. doi:
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Journal of natural products.
2011 Aug; 74(8):1779-86. doi:
10.1021/np200343t. [PMID: 21800856] - Tsuyoshi Goto, Joo-Young Lee, Aki Teraminami, Yong-Il Kim, Shizuka Hirai, Taku Uemura, Hiroyasu Inoue, Nobuyuki Takahashi, Teruo Kawada. Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes.
Journal of lipid research.
2011 May; 52(5):873-84. doi:
10.1194/jlr.m011320. [PMID: 21324916] - Joo-Young Lee, Hikari Hashizaki, Tsuyoshi Goto, Tomoya Sakamoto, Nobuyuki Takahashi, Teruo Kawada. Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes.
Biochemical and biophysical research communications.
2011 Apr; 407(4):818-22. doi:
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Journal of cellular biochemistry.
2011 Feb; 112(2):675-83. doi:
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Bioorganic & medicinal chemistry letters.
2010 Apr; 20(8):2469-73. doi:
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Endocrinology.
2010 Jan; 151(1):123-33. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
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European journal of pharmacology.
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Endocrinology.
2009 Apr; 150(4):1976-83. doi:
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The Journal of endocrinology.
2009 Feb; 200(2):127-38. doi:
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Bioorganic & medicinal chemistry letters.
2008 Feb; 18(3):1110-5. doi:
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Stem cells (Dayton, Ohio).
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Circulation.
2007 Sep; 116(12):1404-12. doi:
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The Journal of pharmacology and experimental therapeutics.
2005 Jul; 314(1):260-70. doi:
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Neuropharmacology.
2005 Jun; 48(8):1147-53. doi:
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Circulation.
2003 Nov; 108(19):2393-9. doi:
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Diabetes.
2002 Apr; 51(4):901-9. doi:
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