nbqx (BioDeep_00001875129)
Main id: BioDeep_00000009497
Volatile Flavor Compounds
代谢物信息卡片
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
化学式: C12H8N4O6S (336.0164548)
中文名称: 二羟基喹酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=C3C(=CC(=C2C(=C1)S(=O)(=O)N)[N+](=O)[O-])NC(=O)C(=O)N3
InChI: InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
描述信息
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
NBQX (FG9202) is a highly selective and competitive AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity[1].
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:31073
- KEGG: C13667
- PubChem: 3272524
- ChEMBL: CHEMBL222519
- CAS: 118876-58-7
- PubChem: 586260
- PDB-CCD: E2Q
- NIKKAJI: J356.947K
- medchemexpress: HY-15068
- KNApSAcK: 31073
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuya Miyamoto, Masatoshi Nakatsuji, Takuya Yoshida, Tadayasu Ohkubo, Takashi Inui. Structural and interaction analysis of human lipocalin-type prostaglandin D synthase with the poorly water-soluble drug NBQX.
The FEBS journal.
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10.1016/0028-3908(93)90145-s. [PMID: 7694171] - V Dall, U Orntoft, A Schmidt, L Nordholm. Interaction of the competitive AMPA receptor antagonist NBQX with hexobarbital.
Pharmacology, biochemistry, and behavior.
1993 Sep; 46(1):73-6. doi:
10.1016/0091-3057(93)90319-o. [PMID: 8255925] - C Thomsen, E R Mulvihill, B Haldeman, D S Pickering, D R Hampson, P D Suzdak. A pharmacological characterization of the mGluR1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line.
Brain research.
1993 Aug; 619(1-2):22-8. doi:
10.1016/0006-8993(93)91592-g. [PMID: 7690672] - K S Pai, S K Shankar, V Ravindranath. Billion-fold difference in the toxic potencies of two excitatory plant amino acids, L-BOAA and L-BMAA: biochemical and morphological studies using mouse brain slices.
Neuroscience research.
1993 Aug; 17(3):241-8. doi:
10.1016/0168-0102(93)90051-q. [PMID: 7901822] - S H Ingwersen. Combined reversed phase and anion exchange solid phase extraction for the assay of the neuroprotectant NBQX in human plasma and urine.
Biomedical chromatography : BMC.
1993 May; 7(3):166-71. doi:
10.1002/bmc.1130070314. [PMID: 8318836] - C McFarlane, D S Warner, M M Todd, L Nordholm. AMPA receptor competitive antagonism reduces halothane MAC in rats.
Anesthesiology.
1992 Dec; 77(6):1165-70. doi:
10.1097/00000542-199212000-00018. [PMID: 1334638] - R Gill, L Nordholm, D Lodge. The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model.
Brain research.
1992 May; 580(1-2):35-43. doi:
10.1016/0006-8993(92)90924-x. [PMID: 1504814] - W E Hoffman, D Pelligrino, C Werner, E Kochs, R F Albrecht, J Schulte am Esch. Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats.
Anesthesiology.
1992 May; 76(5):755-62. doi:
10.1097/00000542-199205000-00014. [PMID: 1575344] - I Westergren, B B Johansson. NBQX, an AMPA antagonist, reduces glutamate-mediated brain edema.
Brain research.
1992 Feb; 573(2):324-6. doi:
10.1016/0006-8993(92)90781-4. [PMID: 1354550] - L Nordholm. Determination of the neuroprotective agent 6-nitro-7-sulphamoylbenzo[f]quinoxaline-2,3-dione in plasma using high-performance liquid chromatography.
Journal of chromatography.
1991 Aug; 568(2):481-6. doi:
10.1016/0378-4347(91)80187-h. [PMID: 1783654]