4-Hydroxystilbene (BioDeep_00001874748)

Main id: BioDeep_00000010134

 


代谢物信息卡片


trans-4-hydroxystilbene;

化学式: C14H12O (196.0888)
中文名称: 反式-4-羟基二苯乙烯, 4-羟基芪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(O)=CC=C(/C=C/C2=CC=CC=C2)C=C1
InChI: InChI=1S/C14H12O/c15-14-10-8-13(9-11-14)7-6-12-4-2-1-3-5-12/h1-11,15H/b7-6+



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ACE, ANXA5, BCL2, CASP3, CASP9, CYP1A1, DNMT3A, ESR1, HDAC1, PIK3CA, PTK2
Peripheral membrane protein 5 ANXA5, CYP1A1, CYP1B1, ESR1, PTK2
Endoplasmic reticulum membrane 4 BCL2, CYP1A1, CYP1A2, CYP1B1
Nucleus 9 BCL2, CASP3, CASP9, DNMT3A, ESR1, HDAC1, PARP1, PPARA, PTK2
cytosol 9 ANXA5, BCL2, CASP3, CASP9, ESR1, HDAC1, PARP1, PIK3CA, PTK2
nuclear body 1 PARP1
centrosome 1 PTK2
nucleoplasm 7 CASP3, DNMT3A, ESR1, FAM20C, HDAC1, PARP1, PPARA
Cell membrane 3 ACE, ESR1, PTK2
Cytoplasmic side 2 ESR1, PTK2
lamellipodium 1 PIK3CA
Golgi apparatus membrane 1 FAM20C
cell cortex 1 PTK2
cell surface 1 UMOD
glutamatergic synapse 1 CASP3
Golgi apparatus 2 ESR1, FAM20C
Golgi membrane 1 FAM20C
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 2 CASP3, HDAC1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 PARP1
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 4 ACE, ESR1, PIK3CA, PTK2
Membrane 7 ACE, ANXA5, BCL2, CYP1B1, ESR1, PARP1, UMOD
apical plasma membrane 1 UMOD
basolateral plasma membrane 1 UMOD
extracellular exosome 4 ACE, ANXA5, FAM20C, UMOD
endoplasmic reticulum 3 BCL2, FAM20C, UMOD
extracellular space 3 ACE, FAM20C, UMOD
perinuclear region of cytoplasm 2 PIK3CA, PTK2
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CASP9, CYP1A1, CYP1B1, PARP1
protein-containing complex 5 BCL2, CASP9, ESR1, HDAC1, PARP1
intracellular membrane-bounded organelle 4 CYP1A1, CYP1A2, CYP1B1, PTK2
Microsome membrane 3 CYP1A1, CYP1A2, CYP1B1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 ACE
Secreted 3 ACE, FAM20C, UMOD
extracellular region 2 ACE, ANXA5
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
anchoring junction 1 PTK2
transcription regulator complex 2 ESR1, PARP1
ciliary membrane 1 UMOD
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PTK2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ACE, ANXA5
dendritic spine 1 PTK2
nucleolus 1 PARP1
Single-pass type II membrane protein 1 FAM20C
Apical cell membrane 1 UMOD
Cytoplasm, perinuclear region 1 PTK2
Mitochondrion inner membrane 1 CYP1A1
heterochromatin 2 DNMT3A, HDAC1
pore complex 1 BCL2
Cell junction, focal adhesion 1 PTK2
Cytoplasm, cytoskeleton 1 PTK2
focal adhesion 2 ANXA5, PTK2
collagen-containing extracellular matrix 1 ANXA5
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 PTK2
cilium 1 UMOD
chromatin 4 ESR1, HDAC1, PARP1, PPARA
cell projection 1 PTK2
Chromosome 2 DNMT3A, PARP1
cytoskeleton 1 PTK2
Cytoplasm, cytoskeleton, cilium basal body 1 PTK2
brush border membrane 1 ACE
Nucleus, nucleolus 1 PARP1
spindle pole 1 UMOD
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
Cytoplasm, cell cortex 1 PTK2
sperm midpiece 1 ACE
Basolateral cell membrane 1 UMOD
Lipid-anchor, GPI-anchor 1 UMOD
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
euchromatin 2 DNMT3A, ESR1
side of membrane 1 UMOD
myelin sheath 1 BCL2
stress fiber 1 PTK2
basal plasma membrane 1 ACE
Golgi lumen 1 UMOD
endoplasmic reticulum lumen 1 FAM20C
nuclear matrix 1 DNMT3A
transcription repressor complex 1 HDAC1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
histone deacetylase complex 1 HDAC1
XY body 1 DNMT3A
extrinsic component of membrane 1 UMOD
NuRD complex 1 HDAC1
apoptosome 1 CASP9
chromosome, centromeric region 1 DNMT3A
vesicle membrane 1 ANXA5
[Isoform 1]: Nucleus 1 ESR1
Sin3-type complex 1 HDAC1
protein-DNA complex 1 PARP1
death-inducing signaling complex 1 CASP3
Cell projection, cilium membrane 1 UMOD
site of DNA damage 1 PARP1
catalytic complex 1 DNMT3A
[Uromodulin, secreted form]: Secreted 1 UMOD
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9


文献列表

  • Antonio González-Sarrías, Juan Carlos Espín-Aguilar, Salvador Romero-Reyes, Julio Puigcerver, Mateo Alajarín, José Berná, María Victoria Selma, Juan Carlos Espín. Main Determinants Affecting the Antiproliferative Activity of Stilbenes and Their Gut Microbiota Metabolites in Colon Cancer Cells: A Structure-Activity Relationship Study. International journal of molecular sciences. 2022 Dec; 23(23):. doi: 10.3390/ijms232315102. [PMID: 36499424]
  • Fatma M Abdel Bar, Ghada M Abbas, Ahmed A Gohar, Mohamed-Farid I Lahloub. Antiproliferative activity of stilbene derivatives and other constituents from the stem bark of Morus nigra L. Natural product research. 2020 Dec; 34(24):3506-3513. doi: 10.1080/14786419.2019.1573236. [PMID: 30822142]
  • Syuhei Nakao, Miyuki Mabuchi, Shenglan Wang, Yoko Kogure, Tadashi Shimizu, Koichi Noguchi, Akito Tanaka, Yi Dai. Synthesis of resveratrol derivatives as new analgesic drugs through desensitization of the TRPA1 receptor. Bioorganic & medicinal chemistry letters. 2017 07; 27(14):3167-3172. doi: 10.1016/j.bmcl.2017.05.025. [PMID: 28576617]
  • Hsing-Chun Lin, Ming-Ju Hsieh, Chiung-Huei Peng, Shun-Fa Yang, Chien-Ning Huang. Pterostilbene Inhibits Vascular Smooth Muscle Cells Migration and Matrix Metalloproteinase-2 through Modulation of MAPK Pathway. Journal of food science. 2015 Oct; 80(10):H2331-5. doi: 10.1111/1750-3841.13002. [PMID: 26409033]
  • Yun-Wei Shi, Cai-Ping Wang, Lei Liu, Yang-Liu Liu, Xing Wang, Ye Hong, Zhen Li, Ling-Dong Kong. Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice. Molecular nutrition & food research. 2012 Sep; 56(9):1433-44. doi: 10.1002/mnfr.201100828. [PMID: 22865646]
  • Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chemical research in toxicology. 2003 Oct; 16(10):1338-58. doi: 10.1021/tx030011g. [PMID: 14565775]
  • Mar Larrosa, Francisco A Tomás-Barberán, Juan Carlos Espín. Grape polyphenol resveratrol and the related molecule 4-hydroxystilbene induce growth inhibition, apoptosis, S-phase arrest, and upregulation of cyclins A, E, and B1 in human SK-Mel-28 melanoma cells. Journal of agricultural and food chemistry. 2003 Jul; 51(16):4576-84. doi: 10.1021/jf030073c. [PMID: 14705880]
  • A A Calderón, M A Pedreño, A Ros-Barceló, R Muñoz. Zymographic screening of plant peroxidase isoenzymes oxidizing 4-hydroxystilbenes. Electrophoresis. 1990 Jun; 11(6):507-8. doi: 10.1002/elps.1150110614. [PMID: 1697538]
  • A A Calderón, M A Pedreño, A Ros Barceló, R Muñoz. A spectrophotometric assay for quantitative analysis of the oxidation of 4-hydroxystilbene by peroxidase-H2O2 systems. Journal of biochemical and biophysical methods. 1990 Mar; 20(3):171-80. doi: 10.1016/0165-022x(90)90075-n. [PMID: 2161027]