Benzarone (BioDeep_00001874012)

Main id: BioDeep_00000009917

 

Volatile Flavor Compounds


代谢物信息卡片


2-Ethyl-3-(4-hydroxybenzoyl)benzofuran

化学式: C17H14O3 (266.0942894)
中文名称: 苯扎隆
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC=C(C=C3)O
InChI: InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3

描述信息

C78275 - Agent Affecting Blood or Body Fluid > C29750 - Thrombolytic Agent
D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents
D050299 - Fibrin Modulating Agents
D002317 - Cardiovascular Agents

同义名列表

3 个代谢物同义名

2-Ethyl-3-(4-hydroxybenzoyl)benzofuran; Benzarone; Benzarone



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Stephen J Fey, Krzysztof Wrzesinski. Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line. Toxicological sciences : an official journal of the Society of Toxicology. 2012 Jun; 127(2):403-11. doi: 10.1093/toxsci/kfs122. [PMID: 22454432]
  • Michael F Wempe, Promsuk Jutabha, Bettina Quade, Timothy J Iwen, Morin M Frick, Ian R Ross, Peter J Rice, Naohiko Anzai, Hitoshi Endou. Developing potent human uric acid transporter 1 (hURAT1) inhibitors. Journal of medicinal chemistry. 2011 Apr; 54(8):2701-13. doi: 10.1021/jm1015022. [PMID: 21449597]
  • Ho Jung Shin, Michio Takeda, Atsushi Enomoto, Masaaki Fujimura, Hiroki Miyazaki, Naohiko Anzai, Hitoshi Endou. Interactions of urate transporter URAT1 in human kidney with uricosuric drugs. Nephrology (Carlton, Vic.). 2011 Feb; 16(2):156-62. doi: 10.1111/j.1440-1797.2010.01368.x. [PMID: 21272127]
  • A Gumieniczek, L Przyborowski. Thin-layer chromatographic analysis of some benzofuran derivatives in human plasma. Acta poloniae pharmaceutica. 1994; 51(6):429-32. doi: . [PMID: 7762396]
  • I Walter-Sack, J X de Vries, A Ittensohn, M Kohlmeier, E Weber. Benzbromarone disposition and uricosuric action; evidence for hydroxilation instead of debromination to benzarone. Klinische Wochenschrift. 1988 Feb; 66(4):160-6. doi: 10.1007/bf01727785. [PMID: 3374026]
  • H Iven, H Brasch. The effects of antibiotics and uricosuric drugs on the renal elimination of methotrexate and 7-hydroxymethotrexate in rabbits. Cancer chemotherapy and pharmacology. 1988; 21(4):337-42. doi: 10.1007/bf00264201. [PMID: 3370743]
  • G Babany, D Larrey, D Pessayre, C Degott, B Rueff, J P Benhamou. Chronic active hepatitis caused by benzarone. Journal of hepatology. 1987 Dec; 5(3):332-5. doi: 10.1016/s0168-8278(87)80039-9. [PMID: 3429840]
  • S G Wood, B A John, L F Chasseaud, R Bonn, H Grote, K Sandrock, A Darragh, R F Lambe. Metabolic fate of the thrombolytic agent benzarone in man: comparison with the rat and dog. Xenobiotica; the fate of foreign compounds in biological systems. 1987 Jul; 17(7):881-96. doi: 10.3109/00498258709043998. [PMID: 3660858]
  • J X de Vries, I Walter-Sack, A van de Loo, J Kocher. Determination of benzarone in human plasma and urine by high-performance liquid chromatography and gas chromatography-mass spectrometry. Identification of the conjugates. Journal of chromatography. 1986 Oct; 382(?):167-74. doi: . [PMID: 3782383]
  • A Schmidt, J Staubesand, E Buddecke. [The effect of benzarone on serum lipids and arterial wall of cholesterol fed rats]. Arzneimittel-Forschung. 1982; 32(8):810-5. doi: . [PMID: 6890357]
  • H Vergin, G Bishop. High-performance liquid chromatographic determination of benzbromarone and the main metabolite benzarone in serum. Journal of chromatography. 1980 Sep; 183(3):383-6. doi: 10.1016/s0378-4347(00)81722-3. [PMID: 7419659]
  • J Roth, E Betz, W Schlote. [Influence of 2-ethyl-3-(4-hydroxybenzoyl)-benzofuran (benzarone) on experimental atheromatosis (author's transl)]. Arzneimittel-Forschung. 1980; 30(11):1897-902. doi: . [PMID: 7193000]