Benzarone (BioDeep_00000009917)

 

Secondary id: BioDeep_00001874012

human metabolite blood metabolite


代谢物信息卡片


4-(2-ethyl-1-benzofuran-3-carbonyl)phenol

化学式: C17H14O3 (266.0943)
中文名称: 苯扎隆
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: CCC1=C(C(=O)C2=CC=C(O)C=C2)C2=CC=CC=C2O1
InChI: InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3

描述信息

C78275 - Agent Affecting Blood or Body Fluid > C29750 - Thrombolytic Agent
D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents
D050299 - Fibrin Modulating Agents
D002317 - Cardiovascular Agents

同义名列表

6 个代谢物同义名

4-(2-ethyl-1-benzofuran-3-carbonyl)phenol; 2-Ethyl-3-(4-hydroxybenzoyl)benzofuran; Benzarone; Benzaron; EHBB; Benzarone



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ANG, CYP2C9, EGFR, EP300, EYA2, EYA3, MMP3, PPARG, PTPN1, PTPRF, SIX5
Peripheral membrane protein 1 PTPN1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 4 CYP2C9, EGFR, MMP21, PTPN1
Nucleus 9 ANG, EGFR, EP300, EYA2, EYA3, MMP3, PPARA, PPARG, SIX5
cytosol 8 ANG, EP300, EYA2, GPT, MMP3, PPARG, PTPN1, SIX5
centrosome 1 EYA3
nucleoplasm 6 EP300, EYA2, EYA3, PPARA, PPARG, SIX5
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 1 EGFR
Cytoplasmic side 1 PTPN1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
cell junction 1 EGFR
cell surface 2 EGFR, PLG
glutamatergic synapse 3 EGFR, PLG, PTPN1
Golgi apparatus 1 SIX5
Golgi membrane 1 EGFR
growth cone 1 ANG
neuronal cell body 2 ANG, PTPRF
postsynapse 1 PTPN1
endosome 1 EGFR
plasma membrane 4 CYP2C9, EGFR, PLG, PTPRF
Membrane 4 EGFR, MMP21, PTPN1, PTPRF
apical plasma membrane 1 EGFR
axon 1 CCK
basolateral plasma membrane 1 EGFR
extracellular exosome 4 GPT, MMP7, PLG, PTPRF
endoplasmic reticulum 1 PTPN1
extracellular space 9 ANG, CCK, EGFR, MMP21, MMP26, MMP3, MMP7, MMP8, PLG
perinuclear region of cytoplasm 2 EGFR, PPARG
Schaffer collateral - CA1 synapse 1 PLG
mitochondrion 2 EYA2, MMP3
protein-containing complex 2 EGFR, PTPN1
intracellular membrane-bounded organelle 3 CYP2C9, PPARG, SIX5
Microsome membrane 1 CYP2C9
Single-pass type I membrane protein 1 EGFR
Secreted 5 ANG, CCK, MMP21, MMP3, PLG
extracellular region 8 ANG, CCK, ELN, MMP21, MMP3, MMP7, MMP8, PLG
Single-pass membrane protein 1 PTPRF
mitochondrial matrix 1 PTPN1
transcription regulator complex 2 EP300, SIX5
nuclear membrane 1 EGFR
external side of plasma membrane 1 PLG
Secreted, extracellular space, extracellular matrix 3 ELN, MMP7, MMP8
actin cytoskeleton 1 ANG
nucleolus 1 ANG
Early endosome 1 PTPN1
Single-pass type II membrane protein 1 MMP21
Membrane raft 1 EGFR
focal adhesion 1 EGFR
extracellular matrix 6 ELN, MMP21, MMP26, MMP3, MMP7, MMP8
basement membrane 1 ANG
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 4 ELN, MMP21, MMP8, PLG
receptor complex 2 EGFR, PPARG
neuron projection 1 PTPRF
chromatin 4 EP300, PPARA, PPARG, SIX5
Chromosome 2 ANG, EP300
mitochondrial crista 1 PTPN1
Nucleus, nucleolus 1 ANG
blood microparticle 1 PLG
Endomembrane system 1 PTPN1
endosome lumen 1 PTPN1
sorting endosome 1 PTPN1
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
platelet alpha granule lumen 1 PLG
specific granule lumen 1 MMP8
tertiary granule lumen 1 MMP8
endocytic vesicle 1 ANG
clathrin-coated endocytic vesicle membrane 1 EGFR
histone acetyltransferase complex 1 EP300
protein-DNA complex 1 EP300
elastic fiber 1 ELN
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
angiogenin-PRI complex 1 ANG
cytoplasmic side of endoplasmic reticulum membrane 1 PTPN1


文献列表

  • Stephen J Fey, Krzysztof Wrzesinski. Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line. Toxicological sciences : an official journal of the Society of Toxicology. 2012 Jun; 127(2):403-11. doi: 10.1093/toxsci/kfs122. [PMID: 22454432]
  • Michael F Wempe, Promsuk Jutabha, Bettina Quade, Timothy J Iwen, Morin M Frick, Ian R Ross, Peter J Rice, Naohiko Anzai, Hitoshi Endou. Developing potent human uric acid transporter 1 (hURAT1) inhibitors. Journal of medicinal chemistry. 2011 Apr; 54(8):2701-13. doi: 10.1021/jm1015022. [PMID: 21449597]
  • Ho Jung Shin, Michio Takeda, Atsushi Enomoto, Masaaki Fujimura, Hiroki Miyazaki, Naohiko Anzai, Hitoshi Endou. Interactions of urate transporter URAT1 in human kidney with uricosuric drugs. Nephrology (Carlton, Vic.). 2011 Feb; 16(2):156-62. doi: 10.1111/j.1440-1797.2010.01368.x. [PMID: 21272127]
  • A Gumieniczek, L Przyborowski. Thin-layer chromatographic analysis of some benzofuran derivatives in human plasma. Acta poloniae pharmaceutica. 1994; 51(6):429-32. doi: . [PMID: 7762396]
  • I Walter-Sack, J X de Vries, A Ittensohn, M Kohlmeier, E Weber. Benzbromarone disposition and uricosuric action; evidence for hydroxilation instead of debromination to benzarone. Klinische Wochenschrift. 1988 Feb; 66(4):160-6. doi: 10.1007/bf01727785. [PMID: 3374026]
  • H Iven, H Brasch. The effects of antibiotics and uricosuric drugs on the renal elimination of methotrexate and 7-hydroxymethotrexate in rabbits. Cancer chemotherapy and pharmacology. 1988; 21(4):337-42. doi: 10.1007/bf00264201. [PMID: 3370743]
  • G Babany, D Larrey, D Pessayre, C Degott, B Rueff, J P Benhamou. Chronic active hepatitis caused by benzarone. Journal of hepatology. 1987 Dec; 5(3):332-5. doi: 10.1016/s0168-8278(87)80039-9. [PMID: 3429840]
  • S G Wood, B A John, L F Chasseaud, R Bonn, H Grote, K Sandrock, A Darragh, R F Lambe. Metabolic fate of the thrombolytic agent benzarone in man: comparison with the rat and dog. Xenobiotica; the fate of foreign compounds in biological systems. 1987 Jul; 17(7):881-96. doi: 10.3109/00498258709043998. [PMID: 3660858]
  • J X de Vries, I Walter-Sack, A van de Loo, J Kocher. Determination of benzarone in human plasma and urine by high-performance liquid chromatography and gas chromatography-mass spectrometry. Identification of the conjugates. Journal of chromatography. 1986 Oct; 382(?):167-74. doi: . [PMID: 3782383]
  • A Schmidt, J Staubesand, E Buddecke. [The effect of benzarone on serum lipids and arterial wall of cholesterol fed rats]. Arzneimittel-Forschung. 1982; 32(8):810-5. doi: . [PMID: 6890357]
  • H Vergin, G Bishop. High-performance liquid chromatographic determination of benzbromarone and the main metabolite benzarone in serum. Journal of chromatography. 1980 Sep; 183(3):383-6. doi: 10.1016/s0378-4347(00)81722-3. [PMID: 7419659]
  • J Roth, E Betz, W Schlote. [Influence of 2-ethyl-3-(4-hydroxybenzoyl)-benzofuran (benzarone) on experimental atheromatosis (author's transl)]. Arzneimittel-Forschung. 1980; 30(11):1897-902. doi: . [PMID: 7193000]