(1R,3R,8R,12S,13R,17R,18E,20Z,24R,25S,26R)-12-hydroxy-17-[(1R)-1-hydroxyethyl]-5,13,25-trimethylspiro[2,10,16,23-tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa-4,18,20-triene-26,2-oxirane]-11,22-dione (BioDeep_00001870432)

Main id: BioDeep_00000003928

 


代谢物信息卡片


(1R,3R,8R,12S,13R,17R,18E,20Z,24R,25S,26R)-12-hydroxy-17-[(1R)-1-hydroxyethyl]-5,13,25-trimethylspiro[2,10,16,23-tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa-4,18,20-triene-26,2-oxirane]-11,22-dione

化学式: C29H40O9 (532.2672)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCOC(C=CC=CC(=O)OC2CC3C4(C2(C5(CCC(=CC5O3)C)COC(=O)C1O)C)CO4)C(C)O
InChI: InChI=1S/C29H40O9/c1-17-9-11-28-15-35-26(33)25(32)18(2)10-12-34-20(19(3)30)7-5-6-8-24(31)38-21-14-23(37-22(28)13-17)29(16-36-29)27(21,28)4/h5-8,13,18-23,25,30,32H,9-12,14-16H2,1-4H3/b7-5+,8-6-/t18-,19-,20-,21-,22-,23-,25+,27-,28-,29-/m1/s1

描述信息

D009676 - Noxae > D011042 - Poisons > D014255 - Trichothecenes
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins

同义名列表

2 个代谢物同义名

(1R,3R,8R,12S,13R,17R,18E,20Z,24R,25S,26R)-12-hydroxy-17-[(1R)-1-hydroxyethyl]-5,13,25-trimethylspiro[2,10,16,23-tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa-4,18,20-triene-26,2-oxirane]-11,22-dione; Roridin A



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 CASP1, CASP3, CASP9, DFFB, EIF2AK2, IL18, MAPK8, NLRP3, P2RX7, PML, SRC, TNK1, TTN
Peripheral membrane protein 3 HK1, PML, TNK1
Endoplasmic reticulum membrane 1 PML
Nucleus 10 CASP3, CASP9, DFFB, EIF2AK2, MAPK8, NLRP3, PARP1, PML, SRC, TTN
cytosol 15 CASP1, CASP3, CASP9, CBL, DFFB, EIF2AK2, HK1, IL18, LIPE, MAPK8, NLRP3, PARP1, PML, SRC, TTN
nuclear body 1 PARP1
nucleoplasm 7 CASP3, DFFB, EIF2AK2, MAPK8, PARP1, PML, SRC
Cell membrane 5 CASP1, LIPE, P2RX7, SRC, TNF
Lipid-anchor 1 SRC
Cytoplasmic side 1 PML
ruffle membrane 1 SRC
Early endosome membrane 1 PML
Multi-pass membrane protein 1 P2RX7
Golgi apparatus membrane 1 NLRP3
Synapse 1 MAPK8
cell junction 1 SRC
cell surface 1 TNF
glutamatergic synapse 2 CASP3, SRC
Golgi apparatus 1 CBL
Golgi membrane 1 NLRP3
growth cone 1 CBL
mitochondrial inner membrane 1 SRC
neuromuscular junction 1 P2RX7
neuronal cell body 4 CASP3, P2RX7, SRC, TNF
postsynapse 1 P2RX7
Cytoplasm, cytosol 5 HK1, IL18, LIPE, NLRP3, PARP1
Lysosome 1 SRC
Presynapse 1 P2RX7
plasma membrane 6 CASP1, CBL, P2RX7, SRC, TNF, TNK1
Membrane 6 EIF2AK2, LIPE, NLRP3, P2RX7, PARP1, TNK1
axon 1 MAPK8
caveola 2 LIPE, SRC
extracellular exosome 2 SRC, TTN
endoplasmic reticulum 1 NLRP3
extracellular space 4 IL18, IL2, IL6, TNF
perinuclear region of cytoplasm 3 CBL, EIF2AK2, SRC
mitochondrion 6 CASP9, HK1, NLRP3, P2RX7, PARP1, SRC
protein-containing complex 4 CASP1, CASP9, DFFB, PARP1
postsynaptic density 1 CASP3
Secreted 4 IL18, IL2, IL6, NLRP3
extracellular region 6 IL18, IL2, IL6, NLRP3, TNF, TTN
Mitochondrion outer membrane 1 HK1
mitochondrial outer membrane 1 HK1
transcription regulator complex 1 PARP1
Cell projection, cilium 1 CBL
nuclear membrane 1 PML
external side of plasma membrane 2 P2RX7, TNF
Z disc 1 TTN
nucleolus 4 CASP1, DFFB, PARP1, PML
cell-cell junction 1 P2RX7
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 2 EIF2AK2, SRC
Mitochondrion inner membrane 1 SRC
Membrane raft 4 CBL, HK1, SRC, TNF
Cell junction, focal adhesion 1 SRC
Cytoplasm, cytoskeleton 1 SRC
focal adhesion 2 CBL, SRC
microtubule 1 CASP1
flotillin complex 1 CBL
Nucleus, PML body 1 PML
PML body 1 PML
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 2 CASP1, NLRP3
Late endosome 1 SRC
cilium 1 CBL
chromatin 2 DFFB, PARP1
phagocytic cup 1 TNF
Chromosome 1 PARP1
podosome 1 SRC
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 2 PARP1, PML
actin filament 1 SRC
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
Endomembrane system 1 NLRP3
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
I band 1 TTN
M band 1 TTN
microtubule organizing center 1 NLRP3
dendritic growth cone 1 SRC
synaptic membrane 1 SRC
endoplasmic reticulum lumen 1 IL6
nuclear matrix 1 PML
apoptosome 1 CASP9
condensed nuclear chromosome 1 TTN
AIM2 inflammasome complex 1 CASP1
protein-DNA complex 1 PARP1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
canonical inflammasome complex 1 CASP1
postsynaptic specialization, intracellular component 1 SRC
site of DNA damage 1 PARP1
bleb 1 P2RX7
ribosome 1 EIF2AK2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
dendritic filopodium 1 SRC
striated muscle thin filament 1 TTN
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
organelle 1 TTN


文献列表

  • Loan Thi Thanh Nguyen, Ja Yeong Jang, Tae Yoon Kim, Nan Hee Yu, Ae Ran Park, Seungki Lee, Chang-Hwan Bae, Joo Hong Yeo, Jae-Seoun Hur, Hae Woong Park, Jin-Cheol Kim. Nematicidal activity of verrucarin A and roridin A isolated from Myrothecium verrucaria against Meloidogyne incognita. Pesticide biochemistry and physiology. 2018 Jun; 148(?):133-143. doi: 10.1016/j.pestbp.2018.04.012. [PMID: 29891364]
  • C C García, M L Rosso, M D Bertoni, M S Maier, E B Damonte. Evaluation of the antiviral activity against Junin virus of macrocyclic trichothecenes produced by the hypocrealean epibiont of Baccharis coridifolia. Planta medica. 2002 Mar; 68(3):209-12. doi: 10.1055/s-2002-23134. [PMID: 11914955]
  • B B Jarvis, S Wang, C Cox, M M Rao, V Philip, M S Varaschin, C S Barros. Brazilian Baccharis toxins: livestock poisoning and the isolation of macrocyclic trichothecene glucosides. Natural toxins. 1996; 4(2):58-71. doi: 10.1002/19960402nt2. [PMID: 8726325]
  • R Hack, E Märtlbauer, G Terplan. Production and characterization of monoclonal antibodies to the macrocyclic trichothecene roridin A. Applied and environmental microbiology. 1988 Sep; 54(9):2328-30. doi: 10.1128/aem.54.9.2328-2330.1988. [PMID: 3190229]
  • E Märtlbauer, M Gareis, G Terplan. Enzyme immunoassay for the macrocyclic trichothecene roridin A: production, properties, and use of rabbit antibodies. Applied and environmental microbiology. 1988 Jan; 54(1):225-30. doi: 10.1128/aem.54.1.225-230.1988. [PMID: 3278686]