Safflower yellow (BioDeep_00001869708)

Main id: BioDeep_00000011491

 


代谢物信息卡片


C.I. natural red 26

化学式: C43H42O22 (910.2168)
中文名称: 红花黄
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C=CC(=O)C2=C(C(C(=C(C2=O)C=C3C(=O)C(=C(C(C3=O)(C4C(C(C(C(O4)CO)O)O)O)O)O)C(=O)C=CC5=CC=C(C=C5)O)O)(C6C(C(C(C(O6)CO)O)O)O)O)O)O
InChI: InChI=1S/C43H42O22/c44-14-24-30(52)32(54)34(56)40(64-24)42(62)36(58)20(28(50)26(38(42)60)22(48)11-5-16-1-7-18(46)8-2-16)13-21-29(51)27(23(49)12-6-17-3-9-19(47)10-4-17)39(61)43(63,37(21)59)41-35(57)33(55)31(53)25(15-45)65-41/h1-13,24-25,30-35,40-41,44-47,52-58,60-63H,14-15H2/b11-5+,12-6+,21-13-/t24-,25-,30-,31-,32+,33+,34-,35-,40-,41-,42+,43-/m1/s1

描述信息

同义名列表

3 个代谢物同义名

C.I. natural red 26; Safflower yellow; Carthamin



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ACSL4, CASP1, ELANE, FTH1, HPGDS, MAP2, MAPK1, MMP3, NLRP3, NOS2, PTGS2, RBFOX3
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 2 ACSL4, PTGS2
Cytoplasmic vesicle, autophagosome 1 FTH1
Nucleus 8 FTH1, GABPA, GPX4, MAPK1, MMP3, NLRP3, NOS2, RBFOX3
autophagosome 1 FTH1
cytosol 12 CASP1, ELANE, FTH1, GCLC, GPX4, HPGDS, IL1B, MAP2, MAPK1, MMP3, NLRP3, NOS2
dendrite 2 ADORA1, MAP2
phagocytic vesicle 1 ELANE
centrosome 1 MAPK1
nucleoplasm 4 GABPA, HPGDS, MAPK1, NOS2
Cell membrane 4 ACSL4, ADORA1, CASP1, TNF
Multi-pass membrane protein 1 ADORA1
Golgi apparatus membrane 1 NLRP3
Synapse 2 ADORA1, MAPK1
cell surface 2 ELANE, TNF
dendritic shaft 1 MAP2
Golgi apparatus 1 MAPK1
Golgi membrane 1 NLRP3
neuronal cell body 3 ADORA1, MAP2, TNF
presynaptic membrane 1 ADORA1
Cytoplasm, cytosol 3 IL1B, NLRP3, NOS2
Lysosome 2 FTH1, IL1B
plasma membrane 7 ACSL4, ADORA1, CASP1, F9, MAPK1, NOS2, TNF
presynaptic active zone 1 ADORA1
terminal bouton 1 ADORA1
Membrane 3 ACSL4, FTH1, NLRP3
basolateral plasma membrane 1 ADORA1
caveola 2 MAPK1, PTGS2
extracellular exosome 6 ACSL4, ELANE, F9, FTH1, GPX4, LCN2
endoplasmic reticulum 3 ACSL4, NLRP3, PTGS2
extracellular space 6 ELANE, F9, IL1B, LCN2, MMP3, TNF
perinuclear region of cytoplasm 1 NOS2
mitochondrion 6 ACSL4, GCLC, GPX4, MAPK1, MMP3, NLRP3
protein-containing complex 3 CASP1, GPX4, PTGS2
intracellular membrane-bounded organelle 1 HPGDS
Microsome membrane 2 ACSL4, PTGS2
Secreted 5 F9, IL1B, LCN2, MMP3, NLRP3
extracellular region 9 ELANE, F9, FTH1, IL1B, LCN2, MAPK1, MMP3, NLRP3, TNF
Mitochondrion outer membrane 1 ACSL4
mitochondrial outer membrane 1 ACSL4
Cytoplasmic vesicle lumen 1 LCN2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 MAPK1
external side of plasma membrane 1 TNF
dendritic spine 1 ADORA1
perikaryon 1 RBFOX3
nucleolus 1 CASP1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 MAPK1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 ADORA1
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 1 MAP2
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 1 MAPK1
microtubule 2 CASP1, MAP2
spindle 1 MAPK1
axolemma 1 ADORA1
extracellular matrix 1 MMP3
Peroxisome 1 NOS2
peroxisomal matrix 1 NOS2
peroxisomal membrane 1 ACSL4
collagen-containing extracellular matrix 2 ELANE, F9
secretory granule 2 ELANE, IL1B
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 2 CASP1, NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
dendrite cytoplasm 1 MAP2
Late endosome 1 MAPK1
neuron projection 2 MAP2, PTGS2
chromatin 1 GABPA
microtubule associated complex 1 MAP2
phagocytic cup 1 TNF
mitotic spindle 1 MAPK1
cytoskeleton 1 MAPK1
nuclear envelope 1 GPX4
Endomembrane system 1 NLRP3
Lipid droplet 1 ACSL4
Membrane, caveola 1 MAPK1
microtubule organizing center 1 NLRP3
mitochondria-associated endoplasmic reticulum membrane contact site 1 ACSL4
axon initial segment 1 MAP2
Cell projection, dendrite 1 MAP2
dendritic growth cone 1 MAP2
pseudopodium 1 MAPK1
Peroxisome membrane 1 ACSL4
ficolin-1-rich granule lumen 2 FTH1, MAPK1
Golgi lumen 1 F9
endoplasmic reticulum lumen 3 F9, MAPK1, PTGS2
transcription repressor complex 1 ELANE
specific granule lumen 2 ELANE, LCN2
tertiary granule lumen 1 FTH1
proximal neuron projection 1 MAP2
Single-pass type III membrane protein 1 ACSL4
Secreted, extracellular exosome 1 IL1B
azurophil granule lumen 2 ELANE, MAPK1
calyx of Held 1 ADORA1
AIM2 inflammasome complex 1 CASP1
axon hillock 1 MAP2
basal dendrite 1 MAP2
canonical inflammasome complex 1 CASP1
Cytoplasmic vesicle, phagosome 1 ELANE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
Autolysosome 1 FTH1
ferritin complex 1 FTH1
[Isoform Mitochondrial]: Mitochondrion 1 GPX4
asymmetric synapse 1 ADORA1
apical distal dendrite 1 MAP2
dendritic branch 1 MAP2
dendritic filopodium 1 MAP2
distal dendrite 1 MAP2
primary dendrite 1 MAP2
proximal dendrite 1 MAP2
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
[Isoform Cytoplasmic]: Cytoplasm 1 GPX4
glutamate-cysteine ligase complex 1 GCLC
Cytoplasmic granule lumen 1 LCN2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Xiaorui Lyu, Kemin Yan, Hanyuan Xu, Huijuan Zhu, Hui Pan, Linjie Wang, Hongbo Yang, Fengying Gong. Intragastric safflower yellow and its main component HSYA improve leptin sensitivity before body weight change in diet-induced obese mice. Naunyn-Schmiedeberg's archives of pharmacology. 2022 05; 395(5):579-591. doi: 10.1007/s00210-022-02220-8. [PMID: 35201390]
  • Toshiyuki Waki, Miho Terashita, Naoki Fujita, Keishi Fukuda, Mikiya Kato, Takashi Negishi, Hiromi Uchida, Yuichi Aoki, Seiji Takahashi, Toru Nakayama. Identification of the Genes Coding for Carthamin Synthase, Peroxidase Homologs that Catalyze the Final Enzymatic Step of Red Pigmentation in Safflower (Carthamus tinctorius L.). Plant & cell physiology. 2021 Dec; 62(10):1528-1541. doi: 10.1093/pcp/pcab122. [PMID: 34343331]
  • Shiro Suzuki. Carthamin Synthase Provides New Insight into Traditional 'Beni' Red Pigment Production from Safflowers. Plant & cell physiology. 2021 12; 62(10):1506-1508. doi: 10.1093/pcp/pcab162. [PMID: 34746959]
  • Zong-Jin Pu, Shuo Zhang, Yu-Ping Tang, Xu-Qin Shi, Hui-Juan Tao, Hui Yan, Jia-Qian Chen, Shi-Jun Yue, Yan-Yan Chen, Zhen-Hua Zhu, Gui-Sheng Zhou, Shu-Lan Su, Jin-Ao Duan. Study on changes in pigment composition during the blooming period of safflower based on plant metabolomics and semi-quantitative analysis. Journal of separation science. 2021 Nov; 44(22):4082-4091. doi: 10.1002/jssc.202100439. [PMID: 34514725]
  • Alexei Baerle, Alexandra Savcenco, Pavel Tatarov, Florinela Fetea, Raisa Ivanova, Oxana Radu. Stability limits of a red Carthamin-cellulose complex as a potential food colourant. Food & function. 2021 Sep; 12(17):8037-8043. doi: 10.1039/d1fo01376a. [PMID: 34279018]
  • Chao Du, Jiawei Hou, Chunhui Wang, Mengyu Zhang, Yanjie Zheng, Guang Yang, Yanli Hu. Effects of safflower yellow on cholesterol levels in serum and brain tissue of APP/PS1 mice. Metabolic brain disease. 2021 04; 36(4):557-569. doi: 10.1007/s11011-021-00680-0. [PMID: 33550459]
  • Song Guo, Yubin Xu, Guirong Chen. [Screening and identification of potential targets of carthamin against sepsis]. Zhonghua wei zhong bing ji jiu yi xue. 2021 Jan; 33(1):23-27. doi: 10.3760/cma.j.cn121430-20200508-00368. [PMID: 33565395]
  • Kemin Yan, Xiangqing Wang, Huijuan Zhu, Hui Pan, Linjie Wang, Hongbo Yang, Meijuan Liu, Ming Jin, Baoxia Zang, Fengying Gong. Safflower yellow improves insulin sensitivity in high-fat diet-induced obese mice by promoting peroxisome proliferator-activated receptor-γ2 expression in subcutaneous adipose tissue. Journal of diabetes investigation. 2020 Nov; 11(6):1457-1469. doi: 10.1111/jdi.13285. [PMID: 32356607]
  • Hai Li, Baotian Kan, Lingli Song, Yufa Liu, Xiangdong Jian. Role of the Hippo signaling pathway in safflower yellow pigment treatment of paraquat-induced pulmonary fibrosis. The Journal of international medical research. 2020 Sep; 48(9):300060520905425. doi: 10.1177/0300060520905425. [PMID: 32940100]
  • Yong-Ling Chen, Ben Cai, Wei Zhang, Zhuo-Qi Xie, Wei Huang, Li Pan, Min Lu. [Study on safflower yellow for injection based on cell degranulation and acute anaphylactoid model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Sep; 44(17):3792-3797. doi: 10.19540/j.cnki.cjcmm.20190522.401. [PMID: 31602955]
  • Ling-Mei Li, Jian-Hua Fu, Hao Guo, Xiao Han, Lei Li, Gao-Jie Xin, Yu-Wei Zhao, Qiong Zhang, Qiu-Sheng Zheng, Jian-Xun Liu. [Protective effect of safflower yellow injection against rat MIRI by TLR-NF-κB inflammatory pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Jun; 44(12):2566-2571. doi: 10.19540/j.cnki.cjcmm.20190201.001. [PMID: 31359725]
  • L D Bao, Y Wang, X H Ren, R L Ma, H J Lv, B Agula. Hypolipidemic effect of safflower yellow and primary mechanism analysis. Genetics and molecular research : GMR. 2015 Jun; 14(2):6270-8. doi: 10.4238/2015.june.9.14. [PMID: 26125829]
  • Yuntao Dai, Robert Verpoorte, Young Hae Choi. Natural deep eutectic solvents providing enhanced stability of natural colorants from safflower (Carthamus tinctorius). Food chemistry. 2014 Sep; 159(?):116-21. doi: 10.1016/j.foodchem.2014.02.155. [PMID: 24767033]
  • Nidhal Salem, Kamel Msaada, Salem Elkahoui, Giuseppe Mangano, Sana Azaeiz, Imen Ben Slimen, Sarra Kefi, Giorgio Pintore, Ferid Limam, Brahim Marzouk. Evaluation of antibacterial, antifungal, and antioxidant activities of safflower natural dyes during flowering. BioMed research international. 2014; 2014(?):762397. doi: 10.1155/2014/762397. [PMID: 25045699]
  • Daiwei Zhou, Bingbing Liu, Xiaoshan Xiao, Peng Dai, Songmei Ma, Weihua Huang. The effect of safflower yellow on spinal cord ischemia reperfusion injury in rabbits. Oxidative medicine and cellular longevity. 2013; 2013(?):692302. doi: 10.1155/2013/692302. [PMID: 24381717]
  • Midori Hiramatsu, Tomoko Takahashi, Makiko Komatsu, Toshitaka Kido, Yoshimasa Kasahara. Antioxidant and neuroprotective activities of Mogami-benibana (safflower, Carthamus tinctorius Linne). Neurochemical research. 2009 Apr; 34(4):795-805. doi: 10.1007/s11064-008-9884-5. [PMID: 19082884]
  • Yu Jin, Xiu-li Zhang, Hui Shi, Yuan-sheng Xiao, Yan-xiong Ke, Xing-ya Xue, Fei-fang Zhang, Xin-miao Liang. Characterization of C-glycosyl quinochalcones in Carthamus tinctorius L. by ultraperformance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM. 2008 Apr; 22(8):1275-87. doi: 10.1002/rcm.3468. [PMID: 18383217]
  • Zhiguo Yu, Xiaoxia Gao, Yunli Zhao, Kaishun Bi. HPLC determination of safflor yellow A and three active isoflavones from TCM Naodesheng in rat plasma and tissues and its application to pharmacokinetic studies. Biomedical chromatography : BMC. 2007 Jun; 21(6):577-84. doi: 10.1002/bmc.764. [PMID: 17385809]
  • Yi Li, Zhao-Yang Zhang, Jin-Lan Zhang. Determination of hydroxysafflor yellow A in rat plasma and tissues by high-performance liquid chromatography after oral administration of safflower extract or safflor yellow. Biomedical chromatography : BMC. 2007 Mar; 21(3):326-34. doi: 10.1002/bmc.769. [PMID: 17221936]
  • Z Yang, A Wen, Q Mei, Y Jiang, M Zhao, S Zhang. [Pharmacokinetical study of safflor yellow on rat acute model of blood stasis syndrome]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2001 Oct; 24(10):730-2. doi: NULL. [PMID: 11822287]
  • M H Cho, T R Hahn. Purification and characterization of precarthamin decarboxylase from the yellow petals of Carthamus tinctorius L. Archives of biochemistry and biophysics. 2000 Oct; 382(2):238-44. doi: 10.1006/abbi.2000.1984. [PMID: 11068875]
  • M H Cho, Y S Paik, T R Hahn. Enzymatic conversion of precarthamin to carthamin by a purified enzyme from the yellow petals of safflower. Journal of agricultural and food chemistry. 2000 Sep; 48(9):3917-21. doi: 10.1021/jf9911038. [PMID: 10995291]
  • Y Jin, D Xu, W Xu. [Influence of safflower injection on hemorheology of patients of chronic cor pulmonale during acute attack]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2000 Jun; 20(6):430-2. doi: NULL. [PMID: 11789226]
  • M R Meselhy, S Kadota, M Hattori, T Namba. Metabolism of safflor yellow B by human intestinal bacteria. Journal of natural products. 1993 Jan; 56(1):39-45. doi: 10.1021/np50091a006. [PMID: 8450320]
  • F Liu, Y Wei, X Z Yang, F G Li, J Hu, R F Cheng. [Hypotensive effects of safflower yellow in spontaneously hypertensive rats and influence on plasma renin activity and angiotensin II level]. Yao xue xue bao = Acta pharmaceutica Sinica. 1992; 27(10):785-7. doi: NULL. [PMID: 1293928]
  • Z W Lu, F Liu, J Hu, D Bian, F G Li. [Suppressive effects of safflower yellow on immune functions]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1991 Nov; 12(6):537-42. doi: NULL. [PMID: 1840455]