aspidospermine (BioDeep_00001868785)
Main id: BioDeep_00000007822
natural product
代谢物信息卡片
化学式: C22H30N2O2 (354.2307)
中文名称: 坚木碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC12CCCN3C1C4(CC3)C(CC2)N(C5=C4C=CC=C5OC)C(=O)C
InChI: InChI=1S/C22H30N2O2/c1-4-21-10-6-13-23-14-12-22(20(21)23)16-7-5-8-17(26-3)19(16)24(15(2)25)18(22)9-11-21/h5,7-8,18,20H,4,6,9-14H2,1-3H3/t18-,20-,21-,22-/m1/s1
描述信息
An indole alkaloid having the structure of aspirospermidine methoxylated at C-17 and acetylated at N-1.
同义名列表
3 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:28463
- KEGG: C09042
- PubChem: 227613
- ChEMBL: CHEMBL519457
- CAS: 1935-07-5
- CAS: 466-49-9
- MetaboLights: MTBLC28463
- PubChem: 11234
- KNApSAcK: C00024452
- 3DMET: B02636
- NIKKAJI: J11.323I
- RefMet: Aspidospermine
- KNApSAcK: 28463
- LOTUS: LTS0214196
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
23 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 4056 - Apocynaceae: LTS0214196
- 84858 - Aspidosperma: LTS0214196
- 595542 - Aspidosperma polyneuron: 10.1002/HLCA.19590420331
- 595542 - Aspidosperma polyneuron: LTS0214196
- 141535 - Aspidosperma pyrifolium: 10.1016/S0031-9422(00)84061-3
- 141535 - Aspidosperma pyrifolium: LTS0214196
- 141536 - Aspidosperma quebracho-blanco:
- 141536 - Aspidosperma quebracho-blanco: 10.1016/S0031-9422(00)84061-3
- 141536 - Aspidosperma quebracho-blanco: LTS0214196
- 2759 - Eukaryota: LTS0214196
- 2895326 - Geissospermum argenteum: 10.1016/S0031-9422(00)89308-5
- 3398 - Magnoliopsida: LTS0214196
- 141613 - Strempeliopsis strempelioides:
- 35493 - Streptophyta: LTS0214196
- 1040856 - Strychnos angolensis: 10.1016/B978-1-4831-9671-8.50013-X
- 52861 - Tabernaemontana divaricata: 10.1021/NP50078A010
- 58023 - Tracheophyta: LTS0214196
- 141626 - Vallesia: LTS0214196
- 141627 - Vallesia antillana: 10.1055/S-2006-958014
- 2766519 - Vallesia glabra: LTS0214196
- 60093 - Vinca minor:
- 33090 - Viridiplantae: LTS0214196
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wen-Fang Yi, Duo-Zhi Chen, Xiao Ding, Xiao-Nian Li, Shun-Lin Li, Ying-Tong Di, Yu Zhang, Xiao-Jiang Hao. Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus.
Fitoterapia.
2018 Jul; 128(?):162-168. doi:
10.1016/j.fitote.2018.05.015. [PMID: 29772302] - Hamid R Kalhor, Hossein Ashrafian. Identification of an aspidospermine derivative from borage extract as an anti-amyloid compound: A possible link between protein aggregation and antimalarial drugs.
Phytochemistry.
2017 Aug; 140(?):134-140. doi:
10.1016/j.phytochem.2017.05.001. [PMID: 28499255] - Yan-Hui Fu, Shun-Lin Li, Shi-Fei Li, Hong-Ping He, Ying-Tong Di, Yu Zhang, Xiao-Jiang Hao. Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis.
Fitoterapia.
2014 Oct; 98(?):45-52. doi:
10.1016/j.fitote.2014.07.008. [PMID: 25038470] - Yan-hui Fu, Ying-tong Di, Hong-ping He, Shun-lin Li, Yu Zhang, Xiao-jiang Hao. Angustifonines A and B, cytotoxic bisindole alkaloids from Bousigonia angustifolia.
Journal of natural products.
2014 Jan; 77(1):57-62. doi:
10.1021/np4005823. [PMID: 24417634] - A C Mitaine-Offer, M Sauvain, A Valentin, J Callapa, M Mallié, M Zèches-Hanrot. Antiplasmodial activity of aspidosperma indole alkaloids.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2002 Mar; 9(2):142-5. doi:
10.1078/0944-7113-00094. [PMID: 11995947] - H F Deutsch, M A Evenson, P Drescher, C Sparwasser, P O Madsen. Isolation and biological activity of aspidospermine and quebrachamine from an Aspidosperma tree source.
Journal of pharmaceutical and biomedical analysis.
1994 Oct; 12(10):1283-7. doi:
10.1016/0731-7085(94)00066-2. [PMID: 7841224] - G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
Journal of natural products.
1991 Jan; 54(1):143-54. doi:
10.1021/np50073a012. [PMID: 1710653]
