N-Acetylornithine (BioDeep_00001868635)

Main id: BioDeep_00000001392

 

PANOMIX_OTCML-2023


代谢物信息卡片


N-alpha-Acetyl-L-ornithine

化学式: C7H14N2O3 (174.1004)
中文名称: N-alpha-乙酰基-L-鸟氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC(CCCN)C(=O)O
InChI: InChI=1S/C7H14N2O3/c1-5(10)9-6(7(11)12)3-2-4-8/h6H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t6-/m0/s1

描述信息

N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate.

同义名列表

3 个代谢物同义名

N-alpha-Acetyl-L-ornithine; N-Acetylornithine; N-Acetylornithine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ARG1, AZIN2, GLUL, NOS2, OAT, PTGS1, SYNE1, TLR4
Peripheral membrane protein 1 PTGS1
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 2 PTGS1, RRBP1
Nucleus 5 ARG1, AZIN2, GLUL, NOS2, SYNE1
cytosol 6 ARG1, AZIN2, GLUL, NAGK, NOS2, SLC22A7
dendrite 1 AZIN2
trans-Golgi network 1 AZIN2
nucleoplasm 3 NOS2, OAT, SYNE1
Cell membrane 6 CD80, CD86, GLUL, SLC22A7, TLR4, TNF
Lipid-anchor 1 GLUL
Cytoplasmic side 1 SYNE1
Cytoplasmic granule 1 ARG1
Multi-pass membrane protein 1 SLC22A7
cell surface 5 CD80, CD86, LBP, TLR4, TNF
glutamatergic synapse 1 SYNE1
Golgi apparatus 2 PTGS1, SYNE1
Golgi membrane 1 INS
mitochondrial inner membrane 1 OTC
neuronal cell body 1 TNF
Cytoplasm, cytosol 2 GLUL, NOS2
plasma membrane 8 ATP1B4, CD80, CD86, GLUL, NOS2, SLC22A7, TLR4, TNF
Membrane 9 ATP1B4, AZIN2, CD80, CD86, LBP, RRBP1, SLC22A7, SYNE1, TLR4
apical plasma membrane 1 SLC22A7
axon 1 AZIN2
basolateral plasma membrane 1 SLC22A7
extracellular exosome 5 CD86, GLUL, LBP, NAGK, PTGS1
endoplasmic reticulum 2 GLUL, RRBP1
extracellular space 6 ARG1, CRP, IL6, INS, LBP, TNF
perinuclear region of cytoplasm 4 AZIN2, NOS2, SYNE1, TLR4
mitochondrion 4 AZIN2, GLUL, OAT, OTC
intracellular membrane-bounded organelle 1 PTGS1
Microsome membrane 1 PTGS1
Single-pass type I membrane protein 3 CD80, CD86, TLR4
Secreted 4 CRP, IL6, INS, LBP
extracellular region 6 ARG1, CRP, IL6, INS, LBP, TNF
Single-pass membrane protein 1 RRBP1
Mitochondrion matrix 2 OAT, OTC
mitochondrial matrix 2 OAT, OTC
centriolar satellite 1 CD86
photoreceptor outer segment 1 PTGS1
nuclear membrane 1 SYNE1
external side of plasma membrane 4 CD80, CD86, TLR4, TNF
sodium:potassium-exchanging ATPase complex 1 ATP1B4
perikaryon 1 AZIN2
cytoplasmic vesicle 1 AZIN2
nucleolus 1 SYNE1
midbody 1 SYNE1
Cytoplasm, P-body 1 NOS2
P-body 2 NOS2, SYNE1
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 2 ATP1B4, TNF
postsynaptic membrane 1 SYNE1
Apical cell membrane 1 SLC22A7
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 SYNE1
cis-Golgi network 1 AZIN2
Peroxisome 1 NOS2
peroxisomal matrix 1 NOS2
Nucleus inner membrane 1 ATP1B4
Nucleus outer membrane 1 SYNE1
nuclear inner membrane 1 ATP1B4
nuclear outer membrane 1 SYNE1
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
sarcomere 1 SYNE1
receptor complex 1 TLR4
neuron projection 1 PTGS1
phagocytic cup 2 TLR4, TNF
cytoskeleton 1 SYNE1
Basolateral cell membrane 1 SLC22A7
nuclear envelope 2 ATP1B4, SYNE1
Endomembrane system 1 PTGS1
endosome lumen 1 INS
cell body 1 GLUL
basal plasma membrane 1 SLC22A7
Microsome 1 GLUL
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
specific granule lumen 1 ARG1
transport vesicle 2 AZIN2, INS
Single-pass type III membrane protein 1 RRBP1
azurophil granule lumen 1 ARG1
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 AZIN2, INS
postsynaptic endocytic zone 1 SYNE1
Single-pass type IV membrane protein 1 SYNE1
endoplasmic reticulum-Golgi intermediate compartment 1 AZIN2
Golgi apparatus, cis-Golgi network 1 AZIN2
[Isoform 1]: Cytoplasm, cytosol 1 SLC22A7
postsynaptic actin cytoskeleton 1 SYNE1
dendritic spine head 1 SYNE1
meiotic nuclear membrane microtubule tethering complex 1 SYNE1
glial cell projection 1 GLUL
ribosome 1 RRBP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
interleukin-6 receptor complex 1 IL6
protein complex involved in cell adhesion 1 CD80
Cytoplasmic granule membrane 1 LBP
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform GSRP-56]: Golgi apparatus 1 SYNE1
granular vesicle 1 AZIN2
[Isoform 2]: Basolateral cell membrane 1 SLC22A7


文献列表

  • Shengyuan Luo, Aditya Surapaneni, Zihe Zheng, Eugene P Rhee, Josef Coresh, Adriana M Hung, Girish N Nadkarni, Bing Yu, Eric Boerwinkle, Adrienne Tin, Dan E Arking, Inga Steinbrenner, Pascal Schlosser, Anna Köttgen, Morgan E Grams. NAT8 Variants, N-Acetylated Amino Acids, and Progression of CKD. Clinical journal of the American Society of Nephrology : CJASN. 2020 12; 16(1):37-47. doi: 10.2215/cjn.08600520. [PMID: 33380473]
  • Nanxiang Xiong, Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-Cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G Zacharias, Hong Lin, Hieu S Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J DeBerardinis, Hao Xu, Woo-Ping Ge. Using arterial-venous analysis to characterize cancer metabolic consumption in patients. Nature communications. 2020 06; 11(1):3169. doi: 10.1038/s41467-020-16810-8. [PMID: 32576825]
  • Sarita Devi, Bajanai Nongkhlaw, M Limesh, Roshni M Pasanna, Tinku Thomas, Rebecca Kuriyan, Anura V Kurpad, Arpita Mukhopadhyay. Acyl ethanolamides in Diabetes and Diabetic Nephropathy: Novel targets from untargeted plasma metabolomic profiles of South Asian Indian men. Scientific reports. 2019 12; 9(1):18117. doi: 10.1038/s41598-019-54584-2. [PMID: 31792390]
  • Eleonora Napoli, Andrea Schneider, Jun Yi Wang, Aditi Trivedi, Nika Roa Carrillo, Flora Tassone, Michael Rogawski, Randi J Hagerman, Cecilia Giulivi. Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study. Molecular neurobiology. 2019 May; 56(5):3702-3713. doi: 10.1007/s12035-018-1330-3. [PMID: 30187385]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Barbara Molesini, Serena Zanzoni, Giuseppe Mennella, Gianluca Francese, Alessia Losa, Giuseppe L Rotino, Tiziana Pandolfini. The Arabidopsis N-Acetylornithine Deacetylase Controls Ornithine Biosynthesis via a Linear Pathway with Downstream Effects on Polyamine Levels. Plant & cell physiology. 2017 01; 58(1):130-144. doi: 10.1093/pcp/pcw167. [PMID: 28064246]
  • Ziming Lu, Wuxing Sun, Xuhong Duan, Zhiyun Yang, Yadong Liu, Pengfei Tu. [Chemical constituents from Corydalis yanhusuo]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Jan; 37(2):235-7. doi: . [PMID: 22737858]
  • Eva Arrebola, Francisco M Cazorla, Alejandro Perez-García, Antonio de Vicente. Chemical and metabolic aspects of antimetabolite toxins produced by Pseudomonas syringae pathovars. Toxins. 2011 09; 3(9):1089-110. doi: 10.3390/toxins3091089. [PMID: 22069758]
  • Pilar Martinez-Moya, Steven Alexander Watt, Karsten Niehaus, Jennifer Alcaíno, Marcelo Baeza, Víctor Cifuentes. Proteomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous. BMC microbiology. 2011 Jun; 11(?):131. doi: 10.1186/1471-2180-11-131. [PMID: 21669001]
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  • Alain Perret, Christophe Lechaplais, Sabine Tricot, Nadia Perchat, Carine Vergne, Christine Pellé, Karine Bastard, Annett Kreimeyer, David Vallenet, Anne Zaparucha, Jean Weissenbach, Marcel Salanoubat. A novel acyl-CoA beta-transaminase characterized from a metagenome. PloS one. 2011; 6(8):e22918. doi: 10.1371/journal.pone.0022918. [PMID: 21826218]
  • Markus Schrettl, Nicola Beckmann, John Varga, Thorsten Heinekamp, Ilse D Jacobsen, Christoph Jöchl, Tarek A Moussa, Shaohua Wang, Fabio Gsaller, Michael Blatzer, Ernst R Werner, William C Niermann, Axel A Brakhage, Hubertus Haas. HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS pathogens. 2010 Sep; 6(9):e1001124. doi: 10.1371/journal.ppat.1001124. [PMID: 20941352]
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