N-alpha-acetylornithine (BioDeep_00000001392)

 

Secondary id: BioDeep_00000169927, BioDeep_00000229686, BioDeep_00000400305, BioDeep_00000402786, BioDeep_00000897229, BioDeep_00001868635, BioDeep_00001872043, BioDeep_00001872446

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(2S)-5-Amino-2-acetamidopentanoic acid

化学式: C7H14N2O3 (174.1004)
中文名称: N-alpha-乙酰基-L-鸟氨酸, (S)-2-乙酰氨基-5-氨基戊酸
谱图信息: 最多检出来源 Homo sapiens(blood) 17.59%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

N-alpha-acetylornithine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/n-alpha-acetylornithine (retrieved 2024-12-12) (BioDeep RN: BioDeep_00000001392). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(=O)NC(CCCN)C(=O)O
InChI: InChI=1S/C7H14N2O3/c1-5(10)9-6(7(11)12)3-2-4-8/h6H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t6-/m0/s1

描述信息

N2-Acetylornithine, also known as N(alpha)-acetylornithine, belongs to the class of organic compounds known as N-acyl-L-alpha-amino acids. These are N-acylated alpha-amino acids which have the L-configuration of the alpha-carbon atom. N-Acetylornithine is a minor component of the deproteinized blood plasma of human blood. Human blood plasma contains a variable amount of acetylornithine, averaging 1.1 +/- 0.4 umol/L (range 0.8-0.2 umol/L). Urine contains a very small amount of acetylornithine, approximately 1 nmol/mg creatinine (1 umol/day) (PMID:508804).
Acquisition and generation of the data is financially supported in part by CREST/JST.
CONFIDENCE standard compound; INTERNAL_ID 160
KEIO_ID A032
N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate.

同义名列表

24 个代谢物同义名

(2S)-5-Amino-2-acetamidopentanoic acid; (2S)-2-acetamido-5-Aminopentanoic acid; (2S)-2-acetamido-5-Aminopentanoate; N(alpha)-Acetyl-L-ornithine; N-alpha-Acetyl-L-ornithine; Nalpha-Acetyl-L-ornithine; N-Alpha-Acetyl-Ornithine; N(alpha)-Acetylornithine; N-alpha-Acetylornithine; N(α)-Acetyl-L-ornithine; N(2)-Acetyl-L-ornithine; N|A-Acetyl-L-ornithine; Nalpha-Acetylornithine; Nα-Acetyl-L-ornithine; N2-Acetyl-L-ornithine; N(α)-Acetylornithine; N-Acetyl-L-ornithine; N-α-Acetylornithine; N2-Acetylornithine; Nα-Acetylornithine; N-Acetylornithine; Acetyl-ornithine; AOR; N-Acetylornithine



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

459 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(450)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(6)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Shengyuan Luo, Aditya Surapaneni, Zihe Zheng, Eugene P Rhee, Josef Coresh, Adriana M Hung, Girish N Nadkarni, Bing Yu, Eric Boerwinkle, Adrienne Tin, Dan E Arking, Inga Steinbrenner, Pascal Schlosser, Anna Köttgen, Morgan E Grams. NAT8 Variants, N-Acetylated Amino Acids, and Progression of CKD. Clinical journal of the American Society of Nephrology : CJASN. 2020 12; 16(1):37-47. doi: 10.2215/cjn.08600520. [PMID: 33380473]
  • Nanxiang Xiong, Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-Cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G Zacharias, Hong Lin, Hieu S Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J DeBerardinis, Hao Xu, Woo-Ping Ge. Using arterial-venous analysis to characterize cancer metabolic consumption in patients. Nature communications. 2020 06; 11(1):3169. doi: 10.1038/s41467-020-16810-8. [PMID: 32576825]
  • Sarita Devi, Bajanai Nongkhlaw, M Limesh, Roshni M Pasanna, Tinku Thomas, Rebecca Kuriyan, Anura V Kurpad, Arpita Mukhopadhyay. Acyl ethanolamides in Diabetes and Diabetic Nephropathy: Novel targets from untargeted plasma metabolomic profiles of South Asian Indian men. Scientific reports. 2019 12; 9(1):18117. doi: 10.1038/s41598-019-54584-2. [PMID: 31792390]
  • Eleonora Napoli, Andrea Schneider, Jun Yi Wang, Aditi Trivedi, Nika Roa Carrillo, Flora Tassone, Michael Rogawski, Randi J Hagerman, Cecilia Giulivi. Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study. Molecular neurobiology. 2019 May; 56(5):3702-3713. doi: 10.1007/s12035-018-1330-3. [PMID: 30187385]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Barbara Molesini, Serena Zanzoni, Giuseppe Mennella, Gianluca Francese, Alessia Losa, Giuseppe L Rotino, Tiziana Pandolfini. The Arabidopsis N-Acetylornithine Deacetylase Controls Ornithine Biosynthesis via a Linear Pathway with Downstream Effects on Polyamine Levels. Plant & cell physiology. 2017 01; 58(1):130-144. doi: 10.1093/pcp/pcw167. [PMID: 28064246]
  • Ziming Lu, Wuxing Sun, Xuhong Duan, Zhiyun Yang, Yadong Liu, Pengfei Tu. [Chemical constituents from Corydalis yanhusuo]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Jan; 37(2):235-7. doi: . [PMID: 22737858]
  • Eva Arrebola, Francisco M Cazorla, Alejandro Perez-García, Antonio de Vicente. Chemical and metabolic aspects of antimetabolite toxins produced by Pseudomonas syringae pathovars. Toxins. 2011 09; 3(9):1089-110. doi: 10.3390/toxins3091089. [PMID: 22069758]
  • Pilar Martinez-Moya, Steven Alexander Watt, Karsten Niehaus, Jennifer Alcaíno, Marcelo Baeza, Víctor Cifuentes. Proteomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous. BMC microbiology. 2011 Jun; 11(?):131. doi: 10.1186/1471-2180-11-131. [PMID: 21669001]
  • Fuqiang Yin, Agnieszka Pajak, Ralph Chapman, Andrew Sharpe, Shangzhi Huang, Frédéric Marsolais. Analysis of common bean expressed sequence tags identifies sulfur metabolic pathways active in seed and sulfur-rich proteins highly expressed in the absence of phaseolin and major lectins. BMC genomics. 2011 May; 12(?):268. doi: 10.1186/1471-2164-12-268. [PMID: 21615926]
  • Naruo Nikoh, Takahiro Hosokawa, Kenshiro Oshima, Masahira Hattori, Takema Fukatsu. Reductive evolution of bacterial genome in insect gut environment. Genome biology and evolution. 2011; 3(?):702-14. doi: 10.1093/gbe/evr064. [PMID: 21737395]
  • Alain Perret, Christophe Lechaplais, Sabine Tricot, Nadia Perchat, Carine Vergne, Christine Pellé, Karine Bastard, Annett Kreimeyer, David Vallenet, Anne Zaparucha, Jean Weissenbach, Marcel Salanoubat. A novel acyl-CoA beta-transaminase characterized from a metagenome. PloS one. 2011; 6(8):e22918. doi: 10.1371/journal.pone.0022918. [PMID: 21826218]
  • Markus Schrettl, Nicola Beckmann, John Varga, Thorsten Heinekamp, Ilse D Jacobsen, Christoph Jöchl, Tarek A Moussa, Shaohua Wang, Fabio Gsaller, Michael Blatzer, Ernst R Werner, William C Niermann, Axel A Brakhage, Hubertus Haas. HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS pathogens. 2010 Sep; 6(9):e1001124. doi: 10.1371/journal.ppat.1001124. [PMID: 20941352]
  • Ilanit Samolski, Alberto de Luis, Juan Antonio Vizcaíno, Enrique Monte, M Belén Suárez. Gene expression analysis of the biocontrol fungus Trichoderma harzianum in the presence of tomato plants, chitin, or glucose using a high-density oligonucleotide microarray. BMC microbiology. 2009 Oct; 9(?):217. doi: 10.1186/1471-2180-9-217. [PMID: 19825185]
  • Shawn M Clark, Rosa Di Leo, Preetinder K Dhanoa, Owen R Van Cauwenberghe, Robert T Mullen, Barry J Shelp. Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis gamma-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate. Journal of experimental botany. 2009; 60(6):1743-57. doi: 10.1093/jxb/erp044. [PMID: 19264755]
  • Shawn M Clark, Rosa Di Leo, Owen R Van Cauwenberghe, Robert T Mullen, Barry J Shelp. Subcellular localization and expression of multiple tomato gamma-aminobutyrate transaminases that utilize both pyruvate and glyoxylate. Journal of experimental botany. 2009; 60(11):3255-67. doi: 10.1093/jxb/erp161. [PMID: 19470656]
  • Federico Martinelli, Sandra L Uratsu, Russell L Reagan, Ying Chen, David Tricoli, Oliver Fiehn, David M Rocke, Charles S Gasser, Abhaya M Dandekar. Gene regulation in parthenocarpic tomato fruit. Journal of experimental botany. 2009; 60(13):3873-90. doi: 10.1093/jxb/erp227. [PMID: 19700496]
  • Michael Hansen, Carsten Friis, Steve Bowra, Preben Bach Holm, Eva Vincze. A pathway-specific microarray analysis highlights the complex and co-ordinated transcriptional networks of the developing grain of field-grown barley. Journal of experimental botany. 2009; 60(1):153-67. doi: 10.1093/jxb/ern270. [PMID: 19015218]
  • Min Woo Lee, Joanna Jelenska, Jean T Greenberg. Arabidopsis proteins important for modulating defense responses to Pseudomonas syringae that secrete HopW1-1. The Plant journal : for cell and molecular biology. 2008 May; 54(3):452-65. doi: 10.1111/j.1365-313x.2008.03439.x. [PMID: 18266921]
  • Frances M Dupont. Metabolic pathways of the wheat (Triticum aestivum) endosperm amyloplast revealed by proteomics. BMC plant biology. 2008 Apr; 8(?):39. doi: 10.1186/1471-2229-8-39. [PMID: 18419817]
  • Jonathan R Howarth, Saroj Parmar, Janina Jones, Caroline E Shepherd, Delia-Irina Corol, Aimee M Galster, Nathan D Hawkins, Sonia J Miller, John M Baker, Paul J Verrier, Jane L Ward, Michael H Beale, Peter B Barraclough, Malcolm J Hawkesford. Co-ordinated expression of amino acid metabolism in response to N and S deficiency during wheat grain filling. Journal of experimental botany. 2008; 59(13):3675-89. doi: 10.1093/jxb/ern218. [PMID: 18791197]
  • Kentaro Takahara, Kinya Akashi, Akiho Yokota. Purification and characterization of glutamate N-acetyltransferase involved in citrulline accumulation in wild watermelon. The FEBS journal. 2005 Oct; 272(20):5353-64. doi: 10.1111/j.1742-4658.2005.04933.x. [PMID: 16218965]
  • A A Faiers, A Y Loh, D H Osmond. Resolution of rat renin substrates by isoelectric focusing. Canadian journal of biochemistry. 1977 Aug; 55(8):869-75. doi: 10.1139/o77-128. [PMID: 19143]
  • H Pösö, A Kallio, G Scalabrino, J Jänne. Specific inhibition of the synthesis of putrescine and spermidine by 1,3-diaminopropane in rat liver in vivo. Biochimica et biophysica acta. 1977 Mar; 497(1):288-97. doi: 10.1016/0304-4165(77)90162-3. [PMID: 14707]
  • . . . . doi: . [PMID: 21917546]