Picolinamide (BioDeep_00001868530)

Main id: BioDeep_00000003478

 


代谢物信息卡片


PYRIDINE-2-CARBOXAMIDE

化学式: C6H6N2O (122.048)
中文名称: 吡啶酰胺, 吡啶甲酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=NC(=C1)C(=O)N
InChI: InChI=1S/C6H6N2O/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9)

描述信息

同义名列表

4 个代谢物同义名

PYRIDINE-2-CARBOXAMIDE; Picolinamide; Picolinamide; Picolinamide



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 GRM5, LRRK2, MAPK8, PMP2
Peripheral membrane protein 2 ACHE, LRRK2
Endosome membrane 1 CLCN5
Endoplasmic reticulum membrane 1 LRRK2
Nucleus 6 ACHE, CLK2, KDR, MAPK8, MET, PMP2
cytosol 5 CLCN5, IL2RG, LRRK2, MAPK8, PMP2
dendrite 2 GRM5, LRRK2
mitochondrial membrane 1 LRRK2
nuclear body 2 CLK2, MET
phagocytic vesicle 1 LRRK2
trans-Golgi network 1 LRRK2
nucleoplasm 4 CLK2, IL2RG, MAPK8, MET
Cell membrane 9 ACHE, CALHM6, CLCN5, GRM3, GRM4, GRM5, IL2RG, KDR, PROKR2
Cell projection, axon 1 LRRK2
Early endosome membrane 1 GPNMB
Multi-pass membrane protein 7 CALHM6, CLCN5, GRM3, GRM4, GRM5, MT-CYB, PROKR2
Golgi apparatus membrane 2 CLCN5, LRRK2
Synapse 2 ACHE, MAPK8
cell junction 1 KDR
cell surface 3 ACHE, IL2RG, MET
dendritic shaft 1 GRM5
glutamatergic synapse 3 GRM3, GRM5, LRRK2
Golgi apparatus 5 ACHE, CLCN5, KDR, LRRK2, NPY
Golgi membrane 3 CLCN5, INS, LRRK2
growth cone 1 LRRK2
lysosomal membrane 1 CLCN5
mitochondrial inner membrane 2 LRRK2, MT-CYB
neuromuscular junction 1 ACHE
neuronal cell body 3 GRM5, INHA, LRRK2
postsynapse 3 GRM5, LRRK2, MET
presynaptic membrane 1 GRM3
synaptic vesicle 1 CLCN5
Lysosome 1 LRRK2
Presynapse 1 GRM4
endosome 3 IL2RG, KDR, LRRK2
plasma membrane 13 ACHE, BCHE, CALHM6, CLCN5, GPNMB, GRM3, GRM4, GRM5, IL2RG, KDR, LRRK2, MET, PROKR2
synaptic vesicle membrane 1 LRRK2
terminal bouton 1 LRRK2
Membrane 10 ACHE, CALHM6, CLCN5, GPNMB, GRM3, GRM4, GRM5, IL2RG, MET, MT-CYB
axon 3 GRM3, LRRK2, MAPK8
extracellular exosome 2 LRRK2, PMP2
endoplasmic reticulum 3 IL2RG, KDR, LRRK2
extracellular space 6 ACHE, BCHE, INHA, INS, LRRK2, NPY
perinuclear region of cytoplasm 1 ACHE
Schaffer collateral - CA1 synapse 1 GRM5
mitochondrion 2 LRRK2, MT-CYB
intracellular membrane-bounded organelle 1 LRRK2
postsynaptic density 1 GRM3
Single-pass type I membrane protein 2 GPNMB, IL2RG
Secreted 5 ACHE, BCHE, INHA, INS, NPY
extracellular region 7 ACHE, BCHE, INHA, INS, KDR, MET, NPY
Mitochondrion outer membrane 1 LRRK2
Single-pass membrane protein 1 MET
mitochondrial outer membrane 1 LRRK2
[Isoform 2]: Secreted 1 KDR
mitochondrial matrix 1 LRRK2
Extracellular side 1 ACHE
anchoring junction 1 KDR
photoreceptor inner segment 1 INHA
photoreceptor outer segment 1 INHA
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 LRRK2
external side of plasma membrane 2 IL2RG, KDR
dendritic spine 2 GRM3, GRM5
perikaryon 1 LRRK2
cytoplasmic vesicle 2 GRM4, LRRK2
Wnt signalosome 1 LRRK2
Melanosome membrane 1 GPNMB
Early endosome 2 CLCN5, KDR
apical part of cell 1 CLCN5
Golgi-associated vesicle 1 LRRK2
postsynaptic membrane 1 GRM3
Mitochondrion inner membrane 1 MT-CYB
Membrane raft 1 KDR
Cytoplasm, cytoskeleton 1 LRRK2
GABA-ergic synapse 1 NPY
basement membrane 1 ACHE
nuclear speck 1 CLK2
dendrite cytoplasm 1 LRRK2
receptor complex 3 IL2RG, KDR, MET
neuron projection 1 LRRK2
cytoskeleton 1 LRRK2
inhibin A complex 1 INHA
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
sorting endosome 1 KDR
microvillus 1 LRRK2
Cell projection, dendrite 1 LRRK2
Nucleus speckle 1 CLK2
side of membrane 1 ACHE
myelin sheath 1 PMP2
basal plasma membrane 1 MET
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 BCHE, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 LRRK2
postsynaptic density membrane 1 GRM5
immunological synapse 1 CALHM6
neuronal dense core vesicle 1 NPY
nuclear envelope lumen 1 BCHE
respiratory chain complex III 1 MT-CYB
ribonucleoprotein complex 1 LRRK2
[Isoform 1]: Nucleus 1 CLK2
synaptic cleft 1 ACHE
basal dendrite 1 MAPK8
Cytoplasmic vesicle, phagosome 1 LRRK2
presynaptic cytosol 1 LRRK2
astrocyte projection 2 GRM3, GRM5
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
multivesicular body, internal vesicle 1 LRRK2
Autolysosome 1 LRRK2
inhibin B complex 1 INHA
inhibin-betaglycan-ActRII complex 1 INHA
[Isoform H]: Cell membrane 1 ACHE
cytoplasmic side of mitochondrial outer membrane 1 LRRK2
[Isoform 2]: Nucleus speckle 1 CLK2
amphisome 1 LRRK2
caveola neck 1 LRRK2


文献列表

  • Ruhani Sagar, Emily A Jaremba, Jinchao Lou, Michael D Best. Copper-responsive liposomes for triggered cargo release employing a picolinamide-lipid conjugate. Organic & biomolecular chemistry. 2023 02; 21(5):955-959. doi: 10.1039/d2ob01977a. [PMID: 36622111]
  • David H Young, Brigitte Meunier. Characterization of mutants with single and combined Qi and Qo site mutations in Saccharomyces cerevisiae reveals interactions between the picolinamide fungicide CAS-649 and azoxystrobin. Pesticide biochemistry and physiology. 2023 Jan; 189(?):105313. doi: 10.1016/j.pestbp.2022.105313. [PMID: 36549825]
  • Chenglin Yao, Kevin G Meyer, Courtney Gallup, Andrew J Bowling, Andrea Hufnagl, Kyung Myung, Jamie Lutz, Thomas Slanec, Heather E Pence, Javier Delgado, Nick X Wang. Florylpicoxamid, a new picolinamide fungicide with broad spectrum activity. Pest management science. 2021 Oct; 77(10):4483-4496. doi: 10.1002/ps.6483. [PMID: 34010509]
  • Shane D Hellyer, Sabine Albold, Kathy Sengmany, Junaid Singh, Katie Leach, Karen J Gregory. Metabotropic glutamate receptor 5 (mGlu5 )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu5 signaling in recombinant cells and neurons. Journal of neurochemistry. 2019 11; 151(3):301-315. doi: 10.1111/jnc.14844. [PMID: 31376155]
  • Verena Pries, Christina Nöcker, Danish Khan, Philipp Johnen, Zebin Hong, Ashutosh Tripathi, Anna-Lena Keller, Michael Fitz, Francesca Perruccio, Ireos Filipuzzi, Sasikala Thavam, Thomas Aust, Ralph Riedl, Slava Ziegler, Fulvia Bono, Gabriel Schaaf, Vytas A Bankaitis, Herbert Waldmann, Dominic Hoepfner. Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties. Cell chemical biology. 2018 03; 25(3):279-290.e7. doi: 10.1016/j.chembiol.2017.12.007. [PMID: 29307839]
  • Je Ho Ryu, Shinae Kim, Jung A Lee, Hye Young Han, Hyun Joo Son, Hyun Jung Lee, Yong Hyuk Kim, Jae-Sun Kim, Hyeung-Geun Park. Synthesis and optimization of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. Bioorganic & medicinal chemistry letters. 2015 Apr; 25(8):1679-1683. doi: 10.1016/j.bmcl.2015.03.003. [PMID: 25800116]
  • Xiangdong Su, Fabienne Pradaux-Caggiano, Nigel Vicker, Mark P Thomas, Heather Halem, Michael D Culler, Barry V L Potter. Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. ChemMedChem. 2011 Sep; 6(9):1616-29. doi: 10.1002/cmdc.201100182. [PMID: 21714097]
  • Ana Borba, Fabiana Lairion, Anibal Disalvo, Rui Fausto. Interaction of nicotinamide and picolinamide with phosphatidylcholine and phosphatidylethanolamine membranes: a combined approach using dipole potential measurements and quantum chemical calculations. Biochimica et biophysica acta. 2009 Dec; 1788(12):2553-62. doi: 10.1016/j.bbamem.2009.10.007. [PMID: 19840772]
  • Xianyong Yu, Jun Zhang, Shuhui Cai, Pinggui Yi, Zhong Chen. Investigation on the complex of diperoxovanadate with picolinamide. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2009 Jun; 72(5):965-9. doi: 10.1016/j.saa.2008.12.020. [PMID: 19233713]
  • Masayuki Morita, Tsuyoshi Ueda, Tetsuo Yoneda, Tohru Koyanagi, Takahiro Haga. Flonicamid, a novel insecticide with a rapid inhibitory effect on aphid feeding. Pest management science. 2007 Oct; 63(10):969-73. doi: 10.1002/ps.1423. [PMID: 17659536]
  • A Peter Snyder, Jacek P Dworzanski, Ashish Tripathi, Waleed M Maswadeh, Charles H Wick. Correlation of mass spectrometry identified bacterial biomarkers from a fielded pyrolysis-gas chromatography-ion mobility spectrometry biodetector with the microbiological gram stain classification scheme. Analytical chemistry. 2004 Nov; 76(21):6492-9. doi: 10.1021/ac040099i. [PMID: 15516146]
  • George A Smythe, Anne Poljak, Sonia Bustamante, Olgar Braga, Alison Maxwell, Ross Grant, Perminder Sachdev. ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, and brain tissue. Advances in experimental medicine and biology. 2003; 527(?):705-12. doi: 10.1007/978-1-4615-0135-0_83. [PMID: 15206793]
  • T Kawabata, T Ogino, M Mori, M Awai. Effects of nicotinamide and its isomers on iron-induced renal damage. Acta pathologica japonica. 1992 Jul; 42(7):469-75. doi: 10.1111/j.1440-1827.1992.tb03091.x. [PMID: 1414356]
  • P I Campbell, H A al-Mahrouq, M I Abraham, S A Kempson. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. The Journal of pharmacology and experimental therapeutics. 1989 Oct; 251(1):188-92. doi: . [PMID: 2529366]
  • T Kazumi, G Yoshino, Y Yoshida, K Doi, M Yoshida, S Kaneko, S Baba. Biochemical studies on rats with insulin-secreting islet cell tumors induced by streptozotocin: with special reference to physiological response to oral glucose load in the course of and after tumor induction. Endocrinology. 1978 Nov; 103(5):1541-5. doi: 10.1210/endo-103-5-1541. [PMID: 218781]
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