Bleomycin A2 (BioDeep_00001868177)
Main id: BioDeep_00000006357
Chemicals and Drugs
代谢物信息卡片
Bleomycin A2
化学式: C55H84N17O21S3+ (1414.5189554)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O
InChI: InChI=1S/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29-,30+,34-,35-,36-,37+,38+,39-,40-,41-,42-,43-,53+,54-/m0/s1
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01D - Cytotoxic antibiotics and related substances
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:3139
- KEGG: C06854
- PubChem: 5460769
- ChEMBL: CHEMBL403664
- MeSH: Bleomycin
- CAS: 11116-31-7
- MetaboLights: MTBLC3139
- PubChem: 9072
- LipidMAPS: LMPK14000006
- KNApSAcK: C00018738
- 3DMET: B05233
- NIKKAJI: J25.633A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jin Guo, Lin Yang, Haoming Song, Li Bai. Prevention of bleomycin-induced pulmonary fibrosis by vaccination with the Tocilizumab mimotope.
Human vaccines & immunotherapeutics.
2024 Dec; 20(1):2319965. doi:
10.1080/21645515.2024.2319965. [PMID: 38408907] - Quynh-Chi Nguyen, Hoang-Anh Nguyen, Tuan-Anh Pham, Van Thi-Hong Tran, Thuy-Duong Nguyen, Duc-Vinh Pham. Mimosa pudica L. extract ameliorates pulmonary fibrosis via modulation of MAPK signaling pathways and FOXO3 stabilization.
Journal of ethnopharmacology.
2024 Aug; 330(?):118226. doi:
10.1016/j.jep.2024.118226. [PMID: 38670401] - Yulei Liang, Yanan Yan, Na Liu, Jiepeng Wang, Chaoyi Fang. Shengxian decoction improves lung function in rats with bleomycin-induced idiopathic pulmonary fibrosis through the inhibition of PANoptosis.
Journal of ethnopharmacology.
2024 Jul; 329(?):118153. doi:
10.1016/j.jep.2024.118153. [PMID: 38604513] - Yang Ruan, Guoqing Ren, Mingchun Wang, Weichao Lv, Kuniyoshi Shimizu, Chaofeng Zhang. The dual role of 20(S)-protopanaxadiol in alleviating pulmonary fibrosis through the gut-lung axis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155699. doi:
10.1016/j.phymed.2024.155699. [PMID: 38733907] - Yanliang Wu, Wen Shi, Haini Li, Chang Liu, Kuniyoshi Shimizu, Renshi Li, Chaofeng Zhang. Specneuzhenide improves bleomycin-induced pulmonary fibrosis in mice via AMPK-dependent reduction of PD-L1.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155318. doi:
10.1016/j.phymed.2023.155318. [PMID: 38493719] - Zeqi Wu, Ruijia Shi, Shihao Yan, Shaobo Zhang, Bin Lu, Zhenlin Huang, Lili Ji. Integrating network pharmacology, experimental validation and molecular docking to reveal the alleviation of Yinhuang granule on idiopathic pulmonary fibrosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155368. doi:
10.1016/j.phymed.2024.155368. [PMID: 38498951] - Fuqiang Yao, Minghao Xu, Lingjun Dong, Xiao Shen, Yujie Shen, Yisheng Jiang, Ting Zhu, Chu Zhang, Guangmao Yu. Sinomenine attenuates pulmonary fibrosis by downregulating TGF-β1/Smad3, PI3K/Akt and NF-κB signaling pathways.
BMC pulmonary medicine.
2024 May; 24(1):229. doi:
10.1186/s12890-024-03050-5. [PMID: 38730387] - Hong Li, Guang Xin, Qilong Zhou, Xiuxian Yu, Chengyu Wan, Yilan Wang, Ao Wen, Kun Zhang, Boli Zhang, Yu Cao, Wen Huang. Qingkailing granule alleviates pulmonary fibrosis by inhibiting PI3K/AKT and SRC/STAT3 signaling pathways.
Bioorganic chemistry.
2024 May; 146(?):107286. doi:
10.1016/j.bioorg.2024.107286. [PMID: 38537336] - Chanho Lee, Se Hyun Kwak, Jisu Han, Ju Hye Shin, Byunghun Yoo, Yu Seol Lee, Jeong Su Park, Beom Jin Lim, Jin Gu Lee, Young Sam Kim, Song Yee Kim, Soo Han Bae. Repositioning of ezetimibe for the treatment of idiopathic pulmonary fibrosis.
The European respiratory journal.
2024 May; 63(5):. doi:
10.1183/13993003.00580-2023. [PMID: 38359963] - Aritra Bhattacharyya, Ranjha Khan, Joanna Y Lee, Gizachew Tassew, Babak Oskouian, Maria L Allende, Richard L Proia, Xiaoyang Yin, Javier G Ortega, Mallar Bhattacharya, Julie D Saba. Gene therapy with AAV9-SGPL1 in an animal model of lung fibrosis.
The Journal of pathology.
2024 05; 263(1):22-31. doi:
10.1002/path.6256. [PMID: 38332723] - Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang, Guoying Yu. Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts.
Respiratory research.
2024 Apr; 25(1):176. doi:
10.1186/s12931-024-02816-z. [PMID: 38658970] - Siqi Wang, Jiabao Yu, Yang Liu, Jinjin Yu, Yajing Ma, Lili Zhou, Xinyao Liu, Lingyi Liu, Weifeng Li, Xiaofeng Niu. Bletilla striata polysaccharide attenuated the progression of pulmonary fibrosis by inhibiting TGF-β1/Smad signaling pathway.
Journal of ethnopharmacology.
2024 Apr; 323(?):117680. doi:
10.1016/j.jep.2023.117680. [PMID: 38171465] - Chen Li, Xiaorong Feng, Songhang Li, Xing He, Zeli Luo, Xia Cheng, Jie Yao, Jie Xiao, Xiaofei Wang, Dingke Wen, Duanya Liu, Yanfei Li, Hong Zhou, Lu Ma, Tongyu Lin, Xiaoxiao Cai, Yunfeng Lin, Lu Guo, Mu Yang. Tetrahedral DNA loaded siCCR2 restrains M1 macrophage polarization to ameliorate pulmonary fibrosis in chemoradiation-induced murine model.
Molecular therapy : the journal of the American Society of Gene Therapy.
2024 Mar; 32(3):766-782. doi:
10.1016/j.ymthe.2024.01.022. [PMID: 38273656] - Jovanka Vladejić, Martin Kovacik, Jana Zwyrtková, Miriam Szurman-Zubrzycka, Jaroslav Doležel, Ales Pecinka. Zeocin-induced DNA damage response in barley and its dependence on ATR.
Scientific reports.
2024 02; 14(1):3119. doi:
10.1038/s41598-024-53264-0. [PMID: 38326519] - Sana Bahri, Raed Abdennabi, Asma Chaker, Afef Nahdi, Amine Elgheryeni, Mona Mlika, Saloua Jameleddine. Phœnix dactylifera, L. seed oil alleviates Bleomycin-induced pulmonary fibrosis and oxidative stress in Wistar rats.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2024 Feb; ?(?):1-10. doi:
10.1080/1354750x.2024.2311178. [PMID: 38314578] - Yijie Li, Ranyun Chen, Jianzhi Wu, Xiaoyong Xue, Tiegang Liu, Guiying Peng, Ruiyu Wu, Lei Wang, Kexin Jia, Yajie Cai, Xiaojiaoyang Li. Salvianolic acid B protects against pulmonary fibrosis by attenuating stimulating protein 1-mediated macrophage and alveolar type 2 cell senescence.
Phytotherapy research : PTR.
2024 Feb; 38(2):620-635. doi:
10.1002/ptr.8070. [PMID: 37953063] - Yunguang Wang, Xinxin He, Huijie Wang, Wei Hu, Lifang Sun. Qingfei xieding prescription ameliorates mitochondrial DNA-initiated inflammation in bleomycin-induced pulmonary fibrosis through activating autophagy.
Journal of ethnopharmacology.
2024 Jan; 325(?):117820. doi:
10.1016/j.jep.2024.117820. [PMID: 38286157] - Yin Zhang, Yong-Bo Lu, Wei-Jie Zhu, Xiao-Xi Gong, Rui Qian, Yi-Jing Lu, Yu Li, Wei-Feng Yao, Bei-Hua Bao, Yi Zhang, Li Zhang, Fang-Fang Cheng. Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway.
Journal of ethnopharmacology.
2024 Jan; 324(?):117737. doi:
10.1016/j.jep.2024.117737. [PMID: 38228229] - Mengnan Zeng, Aozi Feng, Yingjie Ren, Qinqin Zhang, Ru Wang, Beibei Zhang, Meng Liu, Pengli Guo, Yuhan Zhang, Jun Lyu, Xiaoke Zheng. Salvia miltiorrhiza Bunge extract and Przewalskin ameliorate Bleomycin-induced pulmonary fibrosis by inhibition of apoptosis, oxidative stress and collagen deposition via the TGF-β1 pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 125(?):155339. doi:
10.1016/j.phymed.2024.155339. [PMID: 38237513] - Rajwinder Kaur, Taslim B Shaikh, Hari Priya Sripadi, Madhusudana Kuncha, U V R Vijaya Sarathi, Hitesh Kulhari, Sai Balaji Andugulapati, Ramakrishna Sistla. Nintedanib solid lipid nanoparticles improve oral bioavailability and ameliorate pulmonary fibrosis in vitro and in vivo models.
International journal of pharmaceutics.
2024 Jan; 649(?):123644. doi:
10.1016/j.ijpharm.2023.123644. [PMID: 38040396] - Lifang Sun, Xinxin He, Jiao Kong, Huan Yu, Yunguang Wang. Menstrual blood-derived stem cells exosomal miR-let-7 to ameliorate pulmonary fibrosis through inhibiting ferroptosis by Sp3/HDAC2/Nrf2 signaling pathway.
International immunopharmacology.
2024 Jan; 126(?):111316. doi:
10.1016/j.intimp.2023.111316. [PMID: 38056200] - Shuyu Ge, Zhenghong Guo, Ting Xiao, Pingping Sun, Bo Yang, Yin Ying. Qingfei Tongluo Mixture Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis through mTOR-Dependent Autophagy in Rats.
Mediators of inflammation.
2024; 2024(?):5573353. doi:
10.1155/2024/5573353. [PMID: 38361765] - Ria Das, Sanjib Ray. Allium cepa tests: Exploring bleomycin induced cyto-genotoxicity and altered cell cycle kinetics in root tips meristematic cells.
Mutation research.
2024 Jan; 828(?):111851. doi:
10.1016/j.mrfmmm.2024.111851. [PMID: 38382175] - Menna S Zeyada, Salma M Eraky, Mamdouh M El-Shishtawy. Trigonelline mitigates bleomycin-induced pulmonary inflammation and fibrosis: Insight into NLRP3 inflammasome and SPHK1/S1P/Hippo signaling modulation.
Life sciences.
2024 Jan; 336(?):122272. doi:
10.1016/j.lfs.2023.122272. [PMID: 37981228] - Yuan Ji-Hong, Ma Yu, Yuan Ling-Hong, Gong Jing-Jing, Xu Ling-Li, Wang Lv, Jin Yong-Mei. Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression.
Pharmaceutical biology.
2023 Dec; 61(1):288-297. doi:
10.1080/13880209.2022.2160767. [PMID: 36815239] - Yuanyuan Li, Wenguang Qin, Qiuling Liang, Jiamin Zeng, Qiong Yang, Yuqin Chen, Jian Wang, Wenju Lu. Bufei huoxue capsule alleviates bleomycin-induced pulmonary fibrosis in mice via TGF-β1/Smad2/3 signaling.
Journal of ethnopharmacology.
2023 Nov; 316(?):116733. doi:
10.1016/j.jep.2023.116733. [PMID: 37277082] - Na Hyun Kim, Hee Young Kim, Jang Ho Lee, Inik Chang, Sun-Hee Heo, Jiseon Kim, Jeong Hyun Kim, Jung-Hyun Kang, Sei Won Lee. Superoxide dismutase secreting Bacillus amyloliquefaciens spores attenuate pulmonary fibrosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Oct; 168(?):115647. doi:
10.1016/j.biopha.2023.115647. [PMID: 37826939] - Piao Zhou, Xinhui Wu, Keling Chen, Jing Du, Fei Wang. Buyang Huanwu decoction ameliorates bleomycin-induced pulmonary fibrosis in rats by attenuating the apoptosis of alveolar type II epithelial cells mediated by endoplasmic reticulum stress.
Journal of ethnopharmacology.
2023 Oct; ?(?):117300. doi:
10.1016/j.jep.2023.117300. [PMID: 37813290] - Xueping Wei, Junsong Jing, Rongrong Huang, Ting Zhou, Lianhao Wu, Guoteng Ou, Youping Wu, Jingjin Hu, Wenwen Zhu, Yueguo Wu, Yuanyuan Li, Sheng Zhang, Zhenqiang You. QFAE-nB alleviates pulmonary fibrosis by inhibiting the STING pathway in mice.
Journal of ethnopharmacology.
2023 Oct; 319(Pt 2):117295. doi:
10.1016/j.jep.2023.117295. [PMID: 37806536] - Xiaorun Zhai, Jingyu Zhu, Jiao Li, Zhixu Wang, Gufang Zhang, Yunjuan Nie. Fraxetin alleviates BLM-induced idiopathic pulmonary fibrosis by inhibiting NCOA4-mediated epithelial cell ferroptosis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2023 Oct; ?(?):. doi:
10.1007/s00011-023-01800-5. [PMID: 37798541] - Weiji Lin, Yaqin Song, Tingting Li, Jiahui Yan, Ruiyuan Zhang, Liang Han, Xin Ba, Yao Huang, Kai Qin, Zhe Chen, Yu Wang, Shenghao Tu, Ying Huang. Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Oct; 166(?):115394. doi:
10.1016/j.biopha.2023.115394. [PMID: 37660647] - Yuemei Yan, Dianyu Cao, Jian Liang, Qiaorong Yang, Di Gao, Chen Shen, Feifei Hu, Zheng Li, Yumei Han, Xin Cao, Qiang Wang. Dangui Huoxue Preparation (DHP) Ameliorates Skin Fibrosis, Inflammation, and Vasculopathy in the Bleomycin-Induced Murine Model of Systemic Sclerosis.
Advanced biology.
2023 Sep; ?(?):e2300315. doi:
10.1002/adbi.202300315. [PMID: 37759403] - Fan Wei, Yuzhen Yin, Jie Li, Yibo Chang, Shuyuan Zhang, Wenyu Zhao, Xiaochi Ma. Essential oil from Inula japonica Thunb. And its phenolic constituents ameliorate pulmonary injury and fibrosis in bleomycin-treated mice.
Journal of ethnopharmacology.
2023 Sep; 319(Pt 1):117169. doi:
10.1016/j.jep.2023.117169. [PMID: 37704119] - Qian Zeng, Ting-Ting Zhou, Wen-Jie Huang, Xiao-Ting Huang, Lei Huang, Xiao-Hua Zhang, Xiao-Xue Sang, Yu-Yang Luo, Yu-Mei Tian, Bin Wu, Lin Liu, Zi-Qiang Luo, Bin He, Wei Liu, Si-Yuan Tang. Asarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ.
Scientific reports.
2023 09; 13(1):14706. doi:
10.1038/s41598-023-41933-5. [PMID: 37679587] - Mengjiao Hao, Zhuoji Guan, Zhikang Zhang, Haopeng Ai, Xing Peng, Huihao Zhou, Jun Xu, Qiong Gu. Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin.
Molecular therapy : the journal of the American Society of Gene Therapy.
2023 Aug; ?(?):. doi:
10.1016/j.ymthe.2023.08.017. [PMID: 37641404] - Zhengju Zhang, Xinqi Deng, Wen Gu, Yang Jiao, Canyu Su, Hui Liu, Weiguo Ma, Honghong Zhang, Ruiyang Xiang, Dali Wang, Yanan Wang, Wang Chunguo, Fengxian Meng. Jianghu decoction and its active component polydatin inhibit inflammation and fibrotic lesions in the lungs of ILD mice via the AMPK signaling pathway.
Journal of ethnopharmacology.
2023 Aug; 318(Pt B):117003. doi:
10.1016/j.jep.2023.117003. [PMID: 37543150] - Haoyan Jiao, Shuyu Li, Qingfa Tang. Amygdalin epimers exert discrepant anti-pulmonary fibrosis activity via inhibiting TGF-β1/Smad2/3 pathway.
Pulmonary pharmacology & therapeutics.
2023 Aug; 81(?):102230. doi:
10.1016/j.pupt.2023.102230. [PMID: 37364767] - Yang Liu, Amei Tang, Ming Liu, Changjun Xu, Feng Cao, Changfu Yang. Tuberostemonine may enhance the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis to alleviate pulmonary fibrosis.
Journal of ethnopharmacology.
2023 Aug; 318(Pt B):116983. doi:
10.1016/j.jep.2023.116983. [PMID: 37532076] - Han Li, Yu-Guang Wang, Teng-Fei Chen, Yun-Hang Gao, Ling Song, Yi-Fei Yang, Yue Gao, Wang Huo, Guang-Ping Zhang. Panax notoginseng saponin alleviates pulmonary fibrosis in rats by modulating the renin-angiotensin system.
Journal of ethnopharmacology.
2023 Jul; 318(Pt B):116979. doi:
10.1016/j.jep.2023.116979. [PMID: 37532070] - Xingxu Sun, Haixin Xiang, Zhong Liu, He Xiao, Xin Li, Wenqiao Gong, Lihong Pan, Lizhi Zhao, Jingchun Yao, Chenghong Sun, Guimin Zhang. Jingfang Granules () alleviates bleomycin-induced acute lung injury through regulating PI3K/Akt/mTOR signaling pathway.
Journal of ethnopharmacology.
2023 Jul; 318(Pt A):116946. doi:
10.1016/j.jep.2023.116946. [PMID: 37482261] - Edilburga Reyes-Jiménez, Alma Aurora Ramírez-Hernández, Jovito Cesar Santos-Álvarez, Juan Manuel Velázquez-Enríquez, Karina González-García, Gabriela Carrasco-Torres, Saúl Villa-Treviño, Rafael Baltiérrez-Hoyos, Verónica Rocío Vásquez-Garzón. Coadministration of 3'5-dimaleamylbenzoic acid and quercetin decrease pulmonary fibrosis in a systemic sclerosis model.
International immunopharmacology.
2023 Jul; 122(?):110664. doi:
10.1016/j.intimp.2023.110664. [PMID: 37481854] - Alma Aurora Ramírez-Hernández, Edilburga Reyes-Jiménez, Juan Manuel Velázquez-Enríquez, Jovito Cesar Santos-Álvarez, Adriana Soto-Guzmán, Luis Castro-Sánchez, Gabriela Tapia-Pastrana, Honorio Torres-Aguilar, Verónica Rocío Vásquez-Garzón, Rafael Baltiérrez-Hoyos. Zingiber officinale-Derived Extracellular Vesicles Attenuate Bleomycin-Induced Pulmonary Fibrosis Trough Antioxidant, Anti-Inflammatory and Protease Activity in a Mouse Model.
Cells.
2023 07; 12(14):. doi:
10.3390/cells12141852. [PMID: 37508515] - Yan Li, Xing Wang, Wan-Qiu Zhang, Yu-Long Chen, Rui Zhang. [Effect of Gualou Xiebai Decoction on pulmonary fibrosis in rats based on pyroptosis pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jul; 48(13):3556-3564. doi:
10.19540/j.cnki.cjcmm.20230214.401. [PMID: 37474989] - Cheng-Hui He, Jia-Min Lv, Ghulam Jilany Khan, Hong Duan, Wei Wang, Ke-Feng Zhai, Guo-An Zou, Haji Akber Aisa. Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway.
Phytotherapy research : PTR.
2023 Jul; 37(7):2745-2758. doi:
10.1002/ptr.7771. [PMID: 36794391] - Dali Ding, Xuebin Shen, Lizhen Yu, Yueyue Zheng, Yao Liu, Wei Wang, Li Liu, Zitong Zhao, Sihui Nian, Limin Liu. Timosaponin BII inhibits TGF-β mediated epithelial-mesenchymal transition through Smad-dependent pathway during pulmonary fibrosis.
Phytotherapy research : PTR.
2023 Jul; 37(7):2787-2799. doi:
10.1002/ptr.7774. [PMID: 36807664] - Renquan Zhang, Hui Liang, Gaoli Liu, Wanli Jiang, Zheng Tang, Qinglu Fan, Zhihao Nie, Haifeng Hu, Ganjun Kang, Songping Xie. Nesfatin-1, a novel energy-regulating peptide, alleviates pulmonary fibrosis by blocking TGF-β1/Smad pathway in an AMPKα-dependent manner.
International immunopharmacology.
2023 Jul; 120(?):110369. doi:
10.1016/j.intimp.2023.110369. [PMID: 37224650] - Hyesun Shin, Shinhee Park, Jisu Hong, Ae-Rin Baek, Junehyuk Lee, Do-Jin Kim, An-Soo Jang, Su Sie Chin, Sung Hwan Jeong, Sung-Woo Park. Overexpression of fatty acid synthase attenuates bleomycin induced lung fibrosis by restoring mitochondrial dysfunction in mice.
Scientific reports.
2023 Jun; 13(1):9044. doi:
10.1038/s41598-023-36009-3. [PMID: 37270622] - Yi Wei, Lei Sun, Chao Liu, Lujia Li. Naringin regulates endoplasmic reticulum stress and mitophagy through the ATF3/PINK1 signaling axis to alleviate pulmonary fibrosis.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 06; 396(6):1155-1169. doi:
10.1007/s00210-023-02390-z. [PMID: 36688958] - Xiaoting Lv, Qingquan Chen, Zewei Zhang, Kaili Du, Yaping Huang, Xingzhe Li, Yiming Zeng. αCGRP deficiency aggravates pulmonary fibrosis by activating the PPARγ signaling pathway.
Genes and immunity.
2023 May; ?(?):. doi:
10.1038/s41435-023-00206-x. [PMID: 37231189] - Xing Zhang, Jie Su, Jiacheng Lin, Lujiong Liu, Jiamin Wu, Wenli Yuan, Yibao Zhang, Qi Chen, Zi Jian Su, Guihua Xu, Meng Sun, Yile Zhang, Xuan Chen, Wei Zhang. Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.
Journal of ethnopharmacology.
2023 May; 314(?):116633. doi:
10.1016/j.jep.2023.116633. [PMID: 37207878] - Xiao-Zhou Zou, Zhong-Jie Huang, Zi-Bo Zhan, Meng-Nan Yuan, Yi-Wen Zhang, Ting Liu, Xiao-Ping Hu, Wei-Jiao Fan, Peng-Cheng Chen, Hui Qin, Su Zhang, Yu-Xuan Xia, Shui-Lian Zheng, Zong-Fu Pan, Ping Huang. The alcohol extracts of Sceptridium ternatum (Thunb.) Lyon exert anti-pulmonary fibrosis effect through targeting SETDB1/STAT3/p-STAT3 signaling.
Journal of ethnopharmacology.
2023 Apr; ?(?):116520. doi:
10.1016/j.jep.2023.116520. [PMID: 37120058] - Jiangping He, Cong Yu, Yunlong Shen, Jiao Huang, Yanzi Zhou, Jianmin Gu, Ying Cao, Quan Zheng. Sirtuin 6 ameliorates bleomycin-induced pulmonary fibrosis via activation of lipid catabolism.
Journal of cellular physiology.
2023 Apr; ?(?):. doi:
10.1002/jcp.31027. [PMID: 37099691] - Qiang Zhang, Ting Luo, Dezheng Yuan, Jing Liu, Yi Fu, Jiali Yuan. Qilongtian ameliorate bleomycin-induced pulmonary fibrosis in mice via inhibiting IL-17 signal pathway.
Scientific reports.
2023 04; 13(1):6002. doi:
10.1038/s41598-023-31439-5. [PMID: 37045911] - JiuLing Deng, YuQiong He, GuangChun Sun, Hong Yang, Liang Wang, Xia Tao, WanSheng Chen. Tanreqing injection protects against bleomycin-induced pulmonary fibrosis via inhibiting STING-mediated endoplasmic reticulum stress signaling pathway.
Journal of ethnopharmacology.
2023 Apr; 305(?):116071. doi:
10.1016/j.jep.2022.116071. [PMID: 36584920] - Matteo Massaro, Suhong Wu, Gherardo Baudo, Haoran Liu, Scott Collum, Hyunho Lee, Cinzia Stigliano, Victor Segura-Ibarra, Harry Karmouty-Quintana, Elvin Blanco. Lipid nanoparticle-mediated mRNA delivery in lung fibrosis.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2023 Apr; 183(?):106370. doi:
10.1016/j.ejps.2023.106370. [PMID: 36642345] - Ke Lv, Mingyue Li, Chenghong Sun, Yu Miao, Yan Zhang, Yang Liu, Jianshuang Guo, Qing Meng, Jingchun Yao, Guimin Zhang, Jing Li. Jingfang Granule alleviates bleomycin-induced acute lung injury via CD200-CD200R immunoregulatory pathway.
Journal of ethnopharmacology.
2023 Apr; 311(?):116423. doi:
10.1016/j.jep.2023.116423. [PMID: 37011735] - Aman Gul, Fangyong Yang, Cong Xie, Wenjing Du, Nabijan Mohammadtursun, Bin Wang, Jingjing Le, Jingcheng Dong. Pulmonary fibrosis model of mice induced by different administration methods of bleomycin.
BMC pulmonary medicine.
2023 Mar; 23(1):91. doi:
10.1186/s12890-023-02349-z. [PMID: 36944966] - Jing Liu, Dongyang Gao, Qi Ding, Binbin Zhang, Wenxiang Zhu, Yuanyuan Shi. Sparganii Rhizoma alleviates pulmonary fibrosis by inhibiting fibroblasts differentiation and epithelial-mesenchymal transition mediated by TGF-β1/ Smad2/3 pathway.
Journal of ethnopharmacology.
2023 Mar; ?(?):116305. doi:
10.1016/j.jep.2023.116305. [PMID: 36878395] - Xin Ba, Hui Wang, Yao Huang, JiaHui Yan, Liang Han, WeiJi Lin, Pan Shen, Ying Huang, SiSi Yang, Kai Qin, ShengHao Tu, Zhe Chen. Simiao pill attenuates collagen-induced arthritis and bleomycin-induced pulmonary fibrosis in mice by suppressing the JAK2/STAT3 and TGF-β/Smad2/3 signalling pathway.
Journal of ethnopharmacology.
2023 Feb; ?(?):116274. doi:
10.1016/j.jep.2023.116274. [PMID: 36841380] - Jingxuan Cui, Chengyu Zhang, Hongliang Liu, Lijun Yang, Xiao Liu, Jingjing Zhang, Ying Zhou, Junhua Zhang, Xiaohui Yan. Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis.
ACS applied materials & interfaces.
2023 Feb; ?(?):. doi:
10.1021/acsami.2c20479. [PMID: 36808971] - Yi Wei, Ming Qi, Chao Liu, Lujia Li. Astragalus polysaccharide attenuates bleomycin-induced pulmonary fibrosis by inhibiting TLR4/ NF-κB signaling pathway and regulating gut microbiota.
European journal of pharmacology.
2023 Feb; 944(?):175594. doi:
10.1016/j.ejphar.2023.175594. [PMID: 36804541] - Lu Ding, Yingying Yang, Zeyu Wang, Hang Su, Yaxin Li, Jing Ma, Tingting Bao, Hongyu Qi, Siyu Song, Jing Li, Jiachao Zhao, Ziyuan Wang, Daqing Zhao, Xiangyan Li, Linhua Zhao, Xiaolin Tong. Qimai Feiluoping decoction inhibits mitochondrial complex I-mediated oxidative stress to ameliorate bleomycin-induced pulmonary fibrosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Feb; 112(?):154707. doi:
10.1016/j.phymed.2023.154707. [PMID: 36805483] - Motofumi Kumazoe, Fumiyo Ogawa, Ai Hikida, Yu Shimada, Ren Yoshitomi, Ryoya Watanabe, Hiroaki Onda, Yoshinori Fujimura, Hirofumi Tachibana. Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1.
Scientific reports.
2023 Feb; 13(1):2128. doi:
10.1038/s41598-023-29188-6. [PMID: 36746980] - Chen-Guang Yang, Xue-Li Mao, Jun-Fei Wu, Xiang An, Jia-Jia Cao, Xiao-Yu Zhang, Min Li, Fang-Fang Zhang. Amelioration of Lung Fibrosis by Total Flavonoids of Astragalus via Inflammatory Modulation and Epithelium Regeneration.
The American journal of Chinese medicine.
2023 Jan; ?(?):1-17. doi:
10.1142/s0192415x23500192. [PMID: 36655684] - Hui Tian, Limei Wang, Taoli Fu. Ephedrine alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and restraining NF-κB signaling.
The Journal of toxicological sciences.
2023; 48(10):547-556. doi:
10.2131/jts.48.547. [PMID: 37778983] - Ying Huang, Aili Wang, Sheng Jin, Fang Liu, Fang Xu. Activation of the NLRP3 inflammasome by HMGB1 through inhibition of the Nrf2/HO-1 pathway promotes bleomycin-induced pulmonary fibrosis after acute lung injury in rats.
Allergologia et immunopathologia.
2023; 51(3):56-67. doi:
10.15586/aei.v51i3.668. [PMID: 37169561] - Rafael F Guilherme, José Bruno N F Silva, Ingrid Waclawiack, Vanderlei S Fraga-Junior, Thaís O Nogueira, Cyntia Pecli, Carlla A Araújo-Silva, Nathalia S Magalhães, Felipe S Lemos, Carlos A Bulant, Pablo J Blanco, Rafaela Serra, Erik Svensjö, Júlio Scharfstein, João A Moraes, Claudio Canetti, Claudia F Benjamim. Pleiotropic antifibrotic actions of aspirin-triggered resolvin D1 in the lungs.
Frontiers in immunology.
2023; 14(?):886601. doi:
10.3389/fimmu.2023.886601. [PMID: 36960058] - Sizheng Li, Guang Hu, Lian Kuang, Tianyu Zhou, Haiyan Jiang, Fei Pang, Jie Li, Xinyi Chen, Jie Bao, Wanfang Li, Chuangjun Li, Menglin Li, Lulu Wang, Dongming Zhang, Jinlan Zhang, Zengyan Yang, Hongtao Jin. Unraveling the mechanism of ethyl acetate extract from Prismatomeris connata Y. Z. Ruan root in treating pulmonary fibrosis: insights from bioinformatics, network pharmacology, and experimental validation.
Frontiers in immunology.
2023; 14(?):1330055. doi:
10.3389/fimmu.2023.1330055. [PMID: 38259493] - Su Yuan, Biao Zuo, Si-Cong Zhou, Meng Wang, Kai-Yue Tan, Zhi-Wei Chen, Wen-Fu Cao. Integrating Network Pharmacology and Experimental Validation to Explore the Pharmacological Mechanism of Astragaloside IV in Treating Bleomycin-Induced Pulmonary Fibrosis.
Drug design, development and therapy.
2023; 17(?):1289-1302. doi:
10.2147/dddt.s404710. [PMID: 37138582] - Liqun Wang, Yali Li, Rui Xia, Xinyue Zheng, Xingjie Li, Shouxun Wu, Qianyu Zhang, Sha Li, Yuanle Deng, Yuqin Yao, Tinghong Ye, Wenya Yin. Component analysis and anti-pulmonary fibrosis effects of Rosa sterilis juice.
Food & function.
2022 Dec; 13(24):12915-12924. doi:
10.1039/d2fo02758e. [PMID: 36444933] - Gani Oruqaj, Srikanth Karnati, Lakshmi Kanth Kotarkonda, Eistine Boateng, Marek Bartkuhn, Wenming Zhang, Clemens Ruppert, Andreas Günther, Laurent Bartholin, Wei Shi, Eveline Baumgart-Vogt. Transforming Growth Factor-β1 Regulates Peroxisomal Genes/Proteins via Smad Signaling in Idiopathic Pulmonary Fibrosis Fibroblasts and Transgenic Mouse Models.
The American journal of pathology.
2022 Dec; ?(?):. doi:
10.1016/j.ajpath.2022.11.006. [PMID: 36521562] - Ping Zhan, Xue Lu, Zhao Li, Wen-Jing Wang, Kun Peng, Nan-Nan Liang, Yan Wang, Jian Li, Lin Fu, Hui Zhao, De-Xiang Xu, Zhu-Xia Tan. Mitoquinone alleviates bleomycin-induced acute lung injury via inhibiting mitochondrial ROS-dependent pulmonary epithelial ferroptosis.
International immunopharmacology.
2022 Dec; 113(Pt A):109359. doi:
10.1016/j.intimp.2022.109359. [PMID: 36288647] - Lei Wang, Mei Shao, Wei Jiang, Yangfeng Huang. Resveratrol alleviates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition and down-regulating TLR4/NF-κB and TGF-β1/smad3 signalling pathways in rats.
Tissue & cell.
2022 Dec; 79(?):101953. doi:
10.1016/j.tice.2022.101953. [PMID: 36228366] - Neama M Albanawany, Doaa M Samy, Noha Zahran, Riham M El-Moslemany, Shefaa Mf Elsawy, Maha W Abou Nazel. Histopathological, physiological and biochemical assessment of resveratrol nanocapsules efficacy in bleomycin-induced acute and chronic lung injury in rats.
Drug delivery.
2022 Dec; 29(1):2592-2608. doi:
10.1080/10717544.2022.2105445. [PMID: 35945895] - Jia Yang, Gangdan Jiang, Kaiwen Ni, Liming Fan, Wang Tong, Junchao Yang. Emodin inhibiting epithelial-mesenchymal transition in pulmonary fibrosis through the c-MYC/miR-182-5p/ZEB2 axis.
Phytotherapy research : PTR.
2022 Nov; ?(?):. doi:
10.1002/ptr.7680. [PMID: 36411986] - Ze-Hui Cai, Yan-Ge Tian, Jun-Zi Li, Peng Zhao, Jian-Sheng Li, Xue Mei, Yun-Ping Bai. Peimine ameliorates pulmonary fibrosis via the inhibition of M2-type macrophage polarization through the suppression of P38/Akt/STAT6 signals.
Bioscience reports.
2022 10; 42(10):. doi:
10.1042/bsr20220986. [PMID: 36111628] - Mona Pokharel, Paulina Konarzewska, Jacques Y Roberge, Gil-Soo Han, Yina Wang, George M Carman, Chaoyang Xue. The Anticancer Drug Bleomycin Shows Potent Antifungal Activity by Altering Phospholipid Biosynthesis.
Microbiology spectrum.
2022 10; 10(5):e0086222. doi:
10.1128/spectrum.00862-22. [PMID: 36036637] - Mervat Z Mohamed, Mohamed F Abed El Baky, Merhan E Ali, Heba M Hafez. Aprepitant exerts anti-fibrotic effect via inhibition of TGF-β/Smad3 pathway in bleomycin-induced pulmonary fibrosis in rats.
Environmental toxicology and pharmacology.
2022 Oct; 95(?):103940. doi:
10.1016/j.etap.2022.103940. [PMID: 35931359] - Xian Wu, Hao Gou, Ou Zhou, Huijun Qiu, Hanmin Liu, Zhou Fu, Lina Chen. Human umbilical cord mesenchymal stem cells combined with pirfenidone upregulates the expression of RGS2 in the pulmonary fibrosis in mice.
Respiratory research.
2022 Oct; 23(1):270. doi:
10.1186/s12931-022-02192-6. [PMID: 36182915] - Yue Ding, Lei Wang, Bei Liu, Guoqing Ren, Ryosuke Okubo, Jing Yu, Chaofeng Zhang. Bryodulcosigenin attenuates bleomycin-induced pulmonary fibrosis via inhibiting AMPK-mediated mesenchymal epithelial transition and oxidative stress.
Phytotherapy research : PTR.
2022 Oct; 36(10):3911-3923. doi:
10.1002/ptr.7535. [PMID: 35794782] - Chen Gong, Daiying Xu, Daiyuan Sun, Xue Zhang. PKR Protects the Major Catalytic Subunit of PKA Cpk1 from FgBlm10-Mediated Proteasome Degradation in Fusarium graminearum.
International journal of molecular sciences.
2022 Sep; 23(18):. doi:
10.3390/ijms231810208. [PMID: 36142119] - Hang Li, Caiping Zhao, Gulizeba Muhetaer, Longgang Guo, Kainan Yao, Guiyu Zhang, Yichun Ji, Sizhong Xing, Jihong Zhou, Xiufang Huang. Integrated RNA-sequencing and network pharmacology approach reveals the protection of Yiqi Huoxue formula against idiopathic pulmonary fibrosis by interfering with core transcription factors.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Sep; 104(?):154301. doi:
10.1016/j.phymed.2022.154301. [PMID: 35792448] - Emily R Stevenson, Melissa L Wilkinson, Elena Abramova, Changjiang Guo, Andrew J Gow. Intratracheal Administration of Acyl Coenzyme A Acyltransferase-1 Inhibitor K-604 Reduces Pulmonary Inflammation Following Bleomycin-Induced Lung Injury.
The Journal of pharmacology and experimental therapeutics.
2022 09; 382(3):356-365. doi:
10.1124/jpet.122.001284. [PMID: 35970601] - Xin Miao, Li Liu, Xiang Wang, Zhining Fan, Lin Miao, Jiankun Wang. Clinical efficacy of endoscopic dilation combined with bleomycin injection for benign anastomotic stricture after rectal surgery.
Medicine.
2022 Aug; 101(33):e30036. doi:
10.1097/md.0000000000030036. [PMID: 35984174] - Atanaska Todorova, Teodora Todorova. Apricot kernels' extract and amygdalin alter bleomycin-induced Ty1 retrotransposition, mitotic gene conversion in the trp-5 locus and reverse point mutations in ilv1-92 allele in Saccharomyces cerevisiae.
Archives of microbiology.
2022 Aug; 204(9):542. doi:
10.1007/s00203-022-03155-7. [PMID: 35932430] - Fuxiaonan Zhao, Jianhai Wang, Qi Wang, Zhili Hou, Yingchao Zhang, Xue Li, Qi Wu, Huaiyong Chen. Organoid technology and lung injury mouse models evaluating effects of hydroxychloroquine on lung epithelial regeneration.
Experimental animals.
2022 Aug; 71(3):316-328. doi:
10.1538/expanim.21-0168. [PMID: 35197405] - Joana M Mack, Eric C Peterson, Shelley E Crary, Jeffery H Moran, Kathleen Neville, C D'ann Pierce, Gresham T Richter. Pharmacokinetics of bleomycin sclerotherapy in patients with vascular malformations.
Pediatric blood & cancer.
2022 08; 69(8):e29733. doi:
10.1002/pbc.29733. [PMID: 35484878] - Viktoria Menzel, Matthias Ziegler, Nadhim Hante, Johannes A Sake, Maria Jose Santos-Martinez, Carsten Ehrhardt, Michael Kasper, Kathrin Barth. Fyn-kinase and caveolin-1 in the alveolar epithelial junctional adherence complex contribute to the early stages of pulmonary fibrosis.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2022 Aug; 175(?):106236. doi:
10.1016/j.ejps.2022.106236. [PMID: 35710078] - Wenjing Du, Ting Zhang, Fangyong Yang, Aman Gul, Zhao Tang, Hu Zhang, Shan Jiang, Shiqiang Wang, Jingcheng Dong. Endocannabinoid signalling/cannabinoid receptor 2 is involved in icariin-mediated protective effects against bleomycin-induced pulmonary fibrosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Aug; 103(?):154187. doi:
10.1016/j.phymed.2022.154187. [PMID: 35667261] - Fang Guo, Hongbing Wang, Heshun Xia, Hongwei Shi, Peng Xu, Guoliang Pi. Lymph node metastasis as the initial symptom of a germ cell tumor in an adult: A case report.
Medicine.
2022 Jul; 101(30):e29281. doi:
10.1097/md.0000000000029281. [PMID: 35905234] - Yong Xu, Xuan Wang, Di Han, Junyi Wang, Zichen Luo, Tianzi Jin, Chen Shi, Xianmei Zhou, Lili Lin, Jinjun Shan. Revealing the mechanism of Jiegeng decoction attenuates bleomycin-induced pulmonary fibrosis via PI3K/Akt signaling pathway based on lipidomics and transcriptomics.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jul; 102(?):154207. doi:
10.1016/j.phymed.2022.154207. [PMID: 35660351] - Dong Shao, Xinguang Liu, Jinyan Wu, Ang Zhang, Yunping Bai, Peng Zhao, Jiansheng Li. Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jul; 102(?):154177. doi:
10.1016/j.phymed.2022.154177. [PMID: 35636171] - Karina González-García, Armando López-Martínez, Juan Manuel Velázquez-Enríquez, Cecilia Zertuche-Martínez, Gabriela Carrasco-Torres, Luis Manuel Sánchez-Navarro, Saúl Villa-Treviño, Rafael Baltiérrez-Hoyos, Verónica Rocío Vásquez-Garzón. 3'5-Dimaleamylbenzoic Acid Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice.
International journal of molecular sciences.
2022 Jul; 23(14):. doi:
10.3390/ijms23147943. [PMID: 35887292] - Xuemiao Yang, Guojun Zhao, Yukun Bo, Dan Yang, Zhiqiang Dong, Guodong Wu, Nanbing Xu, Ming An, Longshan Zhao. Mechanisms exploration of Terrestrosin D on pulmonary fibrosis based on plasma metabolomics and network pharmacology.
Biomedical chromatography : BMC.
2022 Jul; ?(?):e5441. doi:
10.1002/bmc.5441. [PMID: 35789496] - Chirine Brinsi, Anouar Abidi, Karim Hosni, Haifa Tounsi, Hichem Sebai. Protective Effect of Eucalyptus globulus Extracts Against Bleomycin-Induced Pulmonary Fibrosis in Rats.
Journal of medicinal food.
2022 Jul; 25(7):741-750. doi:
10.1089/jmf.2021.0152. [PMID: 35834630] - Hidehiko Yagasaki, Susumu Takekoshi, Kanae Kitatani, Chikara Kato, Hiroyuki Yamasaki, Kie Shioyama, Takaaki Tsuboi, Tomohiko Matsuzaki, Yutaka Inagaki, Ryota Masuda, Masayuki Iwazaki. Protective effect of ebselen on bleomycin-induced lung fibrosis: analysis of the molecular mechanism of lung fibrosis mediated by oxidized diacylglycerol.
Free radical research.
2022 Jul; 56(7-8):473-482. doi:
10.1080/10715762.2022.2092477. [PMID: 36562703] - Xian-Zh Lin, Hao Hu, Xu Zhao, Yu-X Qian, Hui Wang, Hua Jiang, Lie Zhu. Animal experimental research of intralesional bleomycin and pingyangmycin in the treatment of xanthoma.
Journal of cosmetic dermatology.
2022 Jul; 21(7):2977-2983. doi:
10.1111/jocd.14500. [PMID: 34619007] - Jorge RuizdelRio, Pedro Muñoz, Patricia Carreira, David Maestro, Jose L Pablos, Ana Palanca, Jesus Merino, Anna Serrano-Mollar, Ramon Merino, Esther Tamayo, Marcos Lopez-Hoyos, Federico Diaz-Gonzalez, Victor Martinez-Taboada, Ana V Villar. Profibrotic Role of Inducible Heat Shock Protein 90α Isoform in Systemic Sclerosis.
Journal of immunology (Baltimore, Md. : 1950).
2022 Jul; 209(1):38-48. doi:
10.4049/jimmunol.2100430. [PMID: 35715007] - Xin Bai, Guolin Zhao, Qijing Chen, Zhongyu Li, Mingzhu Gao, William Ho, Xiaoyang Xu, Xue-Qing Zhang. Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.
Science advances.
2022 06; 8(25):eabn7162. doi:
10.1126/sciadv.abn7162. [PMID: 35731866]