ACRIDINE (BioDeep_00001867800)
Main id: BioDeep_00000002323
代谢物信息卡片
ACRIDINE
化学式: C13H9N (179.0735)
中文名称: 吖啶
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=C3C=CC=CC3=N2
InChI: InChI=1S/C13H9N/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-9H
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:36420
- KEGG: C20141
- PubChem: 9215
- ChEMBL: CHEMBL39677
- MeSH: Acridines
- CAS: 260-94-6
- PubChem: 135626601
- RefMet: Acridine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hai-Yan Peng, Gang Zhang, Ru Sun, Yu-Jie Xu, Jian-Feng Ge. Fluorescent probes based on acridine derivatives and their application in dynamic monitoring of cell polarity variation.
The Analyst.
2022 Nov; 147(22):5231-5238. doi:
10.1039/d2an01449a. [PMID: 36278807] - Marta Świtalska, Beata Filip-Psurska, Magdalena Milczarek, Mateusz Psurski, Adrianna Moszyńska, Aleksandra M Dąbrowska, Małgorzata Gawrońska, Karol Krzymiński, Maciej Bagiński, Rafał Bartoszewski, Joanna Wietrzyk. Combined anticancer therapy with imidazoacridinone analogue C-1305 and paclitaxel in human lung and colon cancer xenografts-Modulation of tumour angiogenesis.
Journal of cellular and molecular medicine.
2022 07; 26(14):3950-3964. doi:
10.1111/jcmm.17430. [PMID: 35701366] - Cissé Sow, Amélie Bouissou, Yvette A Girard, Gurvani B Singh, Lotfi Bounaadja, Jean-Marc Payrat, Delphine Haas, Hervé Isola, Marion C Lanteri, Peter Bringmann, Philippe Grellier. Robust inactivation of Plasmodium falciparum in red blood cell concentrates using amustaline and glutathione pathogen reduction.
Transfusion.
2022 05; 62(5):1073-1083. doi:
10.1111/trf.16867. [PMID: 35385146] - Mária Vilková, Monika Hudáčová, Nikola Palušeková, Rastislav Jendželovský, Miroslav Almáši, Tibor Béres, Peter Fedoročko, Mária Kožurková. Acridine Based N-Acylhydrazone Derivatives as Potential Anticancer Agents: Synthesis, Characterization and ctDNA/HSA Spectroscopic Binding Properties.
Molecules (Basel, Switzerland).
2022 Apr; 27(9):. doi:
10.3390/molecules27092883. [PMID: 35566236] - Yaogeng Wang, Rolf W Sparidans, Jing Wang, Wenlong Li, Maria C Lebre, Jos H Beijnen, Alfred H Schinkel. Rifampin and ritonavir increase oral availability and elacridar enhances overall exposure and brain accumulation of the NTRK inhibitor larotrectinib.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2022 Jan; 170(?):197-207. doi:
10.1016/j.ejpb.2021.12.007. [PMID: 34952136] - Margarida L F Martins, Nancy H C Loos, Sümeyra Mucuk, Danielle de Jong, Maria C Lebre, Hilde Rosing, Matthijs Tibben, Jos H Beijnen, Alfred H Schinkel. P-Glycoprotein (ABCB1/MDR1) Controls Brain Penetration and Intestinal Disposition of the PARP1/2 Inhibitor Niraparib.
Molecular pharmaceutics.
2021 12; 18(12):4371-4384. doi:
10.1021/acs.molpharmaceut.1c00553. [PMID: 34730366] - Islam M Mostafa, Muhammad Rehan Hasan Shah Gilani, Yequan Chen, Baohua Lou, Jianping Li, Guobao Xu. Lucigenin-pyrogallol chemiluminescence for the multiple detection of pyrogallol, cobalt ion, and tyrosinase.
Journal of food and drug analysis.
2021 09; 29(3):510-520. doi:
10.38212/2224-6614.3361. [PMID: 35696239] - Laina Zarisa Mohd Kamal, Mowaffaq Adam Ahmed Adam, Siti Nurfatimah Mohd Shahpudin, Ahmad Naqeeb Shuib, Rosline Sandai, Norazian Mohd Hassan, Yasser Tabana, Dayang Fredalina Basri, Leslie Thian Lung Than, Doblin Sandai. Identification of Alkaloid Compounds Arborinine and Graveoline from Ruta angustifolia (L.) Pers for their Antifungal Potential against Isocitrate lyase (ICL1) gene of Candida albicans.
Mycopathologia.
2021 May; 186(2):221-236. doi:
10.1007/s11046-020-00523-z. [PMID: 33550536] - Christopher Rowbottom, Alicia Pietrasiewicz, Taras Tuczewycz, Richard Grater, Daniel Qiu, Sudarshan Kapadnis, Patrick Trapa. Optimization of dose and route of administration of the P-glycoprotein inhibitor, valspodar (PSC-833) and the P-glycoprotein and breast cancer resistance protein dual-inhibitor, elacridar (GF120918) as dual infusion in rats.
Pharmacology research & perspectives.
2021 04; 9(2):e00740. doi:
10.1002/prp2.740. [PMID: 33660938] - Ahmed M Elissawy, Ebrahim Soleiman Dehkordi, Negin Mehdinezhad, Mohamed L Ashour, Pardis Mohammadi Pour. Cytotoxic Alkaloids Derived from Marine Sponges: A Comprehensive Review.
Biomolecules.
2021 02; 11(2):. doi:
10.3390/biom11020258. [PMID: 33578987] - Song Ding, Christopher L Hackett, Fang Liu, Ryan G Hackett, Ulrich Bierbach. Evaluation of a Platinum-Acridine Anticancer Agent and Its Liposomal Formulation in an in vivo Model of Lung Adenocarcinoma.
ChemMedChem.
2021 01; 16(2):412-419. doi:
10.1002/cmdc.202000637. [PMID: 32975041] - Xia Lv, Rong Bai, Jian-Kun Yan, Hui-Lian Huang, Xiao-Kui Huo, Xiang-Ge Tian, Xin-Yu Zhao, Bao-Jing Zhang, Wen-Yu Zhao, Cheng-Peng Sun. Investigation of the inhibitory effect of protostanes on human carboxylesterase 2 and their interaction: Inhibition kinetics and molecular stimulations.
International journal of biological macromolecules.
2021 Jan; 167(?):1262-1272. doi:
10.1016/j.ijbiomac.2020.11.080. [PMID: 33189757] - Danhua Wang, Yibei Dai, Xuchu Wang, Pan Yu, Shufang Qu, Zhenping Liu, Ying Cao, Lingyu Zhang, Ying Ping, Weiwei Liu, Zhihua Tao. Determination of plasma β-amyloids by rolling circle amplification chemiluminescent immunoassay for noninvasive diagnosis of Alzheimer's disease.
Mikrochimica acta.
2021 01; 188(1):24. doi:
10.1007/s00604-020-04650-8. [PMID: 33404755] - Hao Li, Buer Song, Mamtimin Mahmut, Mukhtar Imerhasan. One-Pot Green Synthesis of Acridine Alkaloid Derivatives and Screening of in vitro Anti-cancer Activity Against Cdc25b and SHP1.
Current organic synthesis.
2021; 18(4):399-405. doi:
10.2174/1570179417666201228165500. [PMID: 33371849] - Miroslawa Cichorek, Anna Ronowska, Krystyna Dzierzbicka, Monika Gensicka-Kowalewska, Milena Deptula, Iwona Pelikant-Malecka. Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Oct; 130(?):110515. doi:
10.1016/j.biopha.2020.110515. [PMID: 34321163] - Alexandra Probst, Cécile Häberli, Dionicio Siegel, Jianbo Huang, Seth Vigneron, Anh P Ta, Danielle E Skinner, Nelly El-Sakkary, Jeremiah D Momper, Jon Gangoiti, Yuxiang Dong, Jonathan L Vennerstrom, Susan A Charman, Conor R Caffrey, Jennifer Keiser. Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.
The Journal of antimicrobial chemotherapy.
2020 10; 75(10):2925-2932. doi:
10.1093/jac/dkaa247. [PMID: 32617557] - Xiyuan Yao, Noah H Watkins, Heather Brown-Harding, Ulrich Bierbach. A membrane transporter determines the spectrum of activity of a potent platinum-acridine hybrid anticancer agent.
Scientific reports.
2020 09; 10(1):15201. doi:
10.1038/s41598-020-72099-z. [PMID: 32939009] - Lenka Tupova, Birgit Hirschmugl, Simona Sucha, Veronika Pilarova, Virág Székely, Éva Bakos, Lucie Novakova, Csilla Özvegy-Laczka, Christian Wadsack, Martina Ceckova. Interplay of drug transporters P-glycoprotein (MDR1), MRP1, OATP1A2 and OATP1B3 in passage of maraviroc across human placenta.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Sep; 129(?):110506. doi:
10.1016/j.biopha.2020.110506. [PMID: 32768979] - Agnieszka Karbownik, Katarzyna Sobańska, Włodzimierz Płotek, Tomasz Grabowski, Agnieszka Klupczynska, Szymon Plewa, Edmund Grześkowiak, Edyta Szałek. The influence of the coadministration of the p-glycoprotein modulator elacridar on the pharmacokinetics of lapatinib and its distribution in the brain and cerebrospinal fluid.
Investigational new drugs.
2020 06; 38(3):574-583. doi:
10.1007/s10637-019-00806-3. [PMID: 31177402] - Kei Suzuki, Kazuhiro Taniyama, Takao Aoyama, Yoshiaki Watanabe. Evaluation of the Role of P-glycoprotein (P-gp)-Mediated Efflux in the Intestinal Absorption of Common Substrates with Elacridar, a P-gp Inhibitor, in Rats.
European journal of drug metabolism and pharmacokinetics.
2020 Jun; 45(3):385-392. doi:
10.1007/s13318-019-00602-7. [PMID: 32078103] - Sabrina Dallavalle, Vladimir Dobričić, Loretta Lazzarato, Elena Gazzano, Miguel Machuqueiro, Ilza Pajeva, Ivanka Tsakovska, Nace Zidar, Roberta Fruttero. Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
2020 05; 50(?):100682. doi:
10.1016/j.drup.2020.100682. [PMID: 32087558] - Mohamed Ibrahim Halawa, Fengxia Wu, Muhammad Nadeem Zafar, Islam M Mostafa, Abubakar Abdussalam, Shuang Han, Guobao Xu. Turn-on fluorescent glutathione detection based on lucigenin and MnO2 nanosheets.
Journal of materials chemistry. B.
2020 04; 8(16):3542-3549. doi:
10.1039/c9tb02158b. [PMID: 31799572] - Wenlong Li, Matthijs Tibben, Yaogeng Wang, Maria C Lebre, Hilde Rosing, Jos H Beijnen, Alfred H Schinkel. P-glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF-β signaling pathway inhibitor galunisertib.
International journal of cancer.
2020 03; 146(6):1631-1642. doi:
10.1002/ijc.32568. [PMID: 31304590] - Mrinal Kanti Si, Anusuya Saha, Bishwajit Ganguly. Exploiting σ-hole interaction to design small uncharged ligand molecules to stabilize G-quadruplex-DNA: a computational study.
Journal of molecular modeling.
2020 Feb; 26(2):38. doi:
10.1007/s00894-019-4282-2. [PMID: 32008146] - Zhixiang Zhu, Ran Guo, Yunqian Li, Shanshan Li, Pengfei Tu. Comparison of three analytical methods for superoxide produced by activated immune cells.
Journal of pharmacological and toxicological methods.
2020 Jan; 101(?):106637. doi:
10.1016/j.vascn.2019.106637. [PMID: 31678429] - Subhajit Ghosh, Tapas Das, Shishu K Suman, Haladhar D Sarma, Ashutosh Dash. Preparation and Preliminary Evaluation of 68Ga-Acridine: An Attempt to Study the Potential of Radiolabeled DNA Intercalator as a PET Radiotracer for Tumor Imaging.
Anti-cancer agents in medicinal chemistry.
2020; 20(13):1538-1547. doi:
10.2174/1871520620666200502002609. [PMID: 32357824] - Subhajit Ghosh, Tapas Das, Shishu K Suman, Chandan Kumar, Haladhar D Sarma, Ashutosh Dash. Targeted Tumor Therapy with Radiolabeled DNA Intercalator: A Possibility? Preclinical Investigations with 177Lu-Acridine.
BioMed research international.
2020; 2020(?):9514357. doi:
10.1155/2020/9514357. [PMID: 32775454] - Alejandra Martínez-Chávez, Stéphanie van Hoppe, Hilde Rosing, Maria C Lebre, Matthijs Tibben, Jos H Beijnen, Alfred H Schinkel. P-glycoprotein Limits Ribociclib Brain Exposure and CYP3A4 Restricts Its Oral Bioavailability.
Molecular pharmaceutics.
2019 09; 16(9):3842-3852. doi:
10.1021/acs.molpharmaceut.9b00475. [PMID: 31329454] - Md Rafi Haider, Kamal Ahmad, Nadeem Siddiqui, Zulphikar Ali, Md Jawaid Akhtar, Neeraj Fuloria, Shivkanya Fuloria, Manickam Ravichandran, M Shahar Yar. Novel 9-(2-(1-arylethylidene)hydrazinyl)acridine derivatives: Target Topoisomerase 1 and growth inhibition of HeLa cancer cells.
Bioorganic chemistry.
2019 07; 88(?):102962. doi:
10.1016/j.bioorg.2019.102962. [PMID: 31085373] - Wenlong Li, Rolf W Sparidans, Yaogeng Wang, Maria C Lebre, Jos H Beijnen, Alfred H Schinkel. Oral coadministration of elacridar and ritonavir enhances brain accumulation and oral availability of the novel ALK/ROS1 inhibitor lorlatinib.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2019 Mar; 136(?):120-130. doi:
10.1016/j.ejpb.2019.01.016. [PMID: 30660696] - Takaomi Shimokawa, Hidenobu Tsutsui, Takeshi Miura, Masashi Takama, Kohei Hayashi, Toru Nishinaka, Tomoyuki Terada, Kozo Yoneda, Masayo Yamagata, Tokihito Yukimura. Post-treatment with JP-1302 protects against renal ischemia/reperfusion-induced acute kidney injury in rats.
Journal of pharmacological sciences.
2019 Mar; 139(3):137-142. doi:
10.1016/j.jphs.2018.12.008. [PMID: 30665845] - Hui Deng, Bowen Gong, Zhiquan Yang, Zhen Li, Huan Zhou, Yashu Zhang, Xiaohui Niu, Sisi Liu, Dengguo Wei. Intensive Distribution of G₂-Quaduplexes in the Pseudorabies Virus Genome and Their Sensitivity to Cations and G-Quadruplex Ligands.
Molecules (Basel, Switzerland).
2019 Feb; 24(4):. doi:
10.3390/molecules24040774. [PMID: 30795541] - Wei Jiang, Tianyi Xia, Yunlei Yun, Mingming Li, Feng Zhang, Shouhong Gao, Wansheng Chen. UHPLC-MS/MS method for simultaneous determination of carbamazepine and its seven major metabolites in serum of epileptic patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Feb; 1108(?):17-24. doi:
10.1016/j.jchromb.2018.12.016. [PMID: 30660838] - Xiyuan Yao, Christopher M Tracy, Ulrich Bierbach. Cysteine-Directed Bioconjugation of a Platinum(II)-Acridine Anticancer Agent.
Inorganic chemistry.
2019 Jan; 58(1):43-46. doi:
10.1021/acs.inorgchem.8b02717. [PMID: 30543413] - Charles K Rono, James Darkwa, Debra Meyer, Banothile C E Makhubela. A Novel Series of N-aryltriazole and N-acridinyltriazole Hybrids as Potential Anticancer Agents.
Current organic synthesis.
2019; 16(6):900-912. doi:
10.2174/1570179416666190704112904. [PMID: 31984911] - Monika Gensicka-Kowalewska, Mirosława Cichorek, Anna Ronowska, Milena Deptuła, Ilona Klejbor, Krystyna Dzierzbicka. Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2019; 15(7):729-737. doi:
10.2174/1573406414666181015145120. [PMID: 30324889] - Shirin Mollazadeh, Amirhossein Sahebkar, Farzin Hadizadeh, Javad Behravan, Sepideh Arabzadeh. Structural and functional aspects of P-glycoprotein and its inhibitors.
Life sciences.
2018 Dec; 214(?):118-123. doi:
10.1016/j.lfs.2018.10.048. [PMID: 30449449] - Rawny Galdino Gouveia, Amélia Galdino Ribeiro, Miguel Ângelo Santos Pinheiro Segundo, Jamerson Ferreira de Oliveira, Maria do Carmo Alves de Lima, Túlio Ricardo Couto de Lima Souza, Sinara Mônica Vitalino de Almeida, Ricardo Olímpio de Moura. Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives.
Bioorganic & medicinal chemistry.
2018 12; 26(22):5911-5921. doi:
10.1016/j.bmc.2018.10.038. [PMID: 30420325] - Hidenobu Tsutsui, Takaomi Shimokawa, Takeshi Miura, Masashi Takama, Toru Nishinaka, Tomoyuki Terada, Masayo Yamagata, Tokihito Yukimura. Inhibition of α2C-adrenoceptors ameliorates cisplatin-induced acute renal failure in rats.
European journal of pharmacology.
2018 Nov; 838(?):113-119. doi:
10.1016/j.ejphar.2018.09.010. [PMID: 30201375] - Wenlong Li, Rolf W Sparidans, Yaogeng Wang, Maria C Lebre, Jos H Beijnen, Alfred H Schinkel. P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability.
Pharmacological research.
2018 11; 137(?):47-55. doi:
10.1016/j.phrs.2018.09.020. [PMID: 30253203] - Lei Feng, Yongliang Yang, Xiaokui Huo, Xiangge Tian, Yujie Feng, Hanwen Yuan, Lijian Zhao, Chao Wang, Peng Chu, Feida Long, Wei Wang, Xiaochi Ma. Highly Selective NIR Probe for Intestinal β-Glucuronidase and High-Throughput Screening Inhibitors to Therapy Intestinal Damage.
ACS sensors.
2018 09; 3(9):1727-1734. doi:
10.1021/acssensors.8b00471. [PMID: 30149692] - Ramit Singla, Kunal Prakash, Kunj Bihari Gupta, Shishir Upadhyay, Monisha Dhiman, Vikas Jaitak. Identification of novel indole based heterocycles as selective estrogen receptor modulator.
Bioorganic chemistry.
2018 09; 79(?):72-88. doi:
10.1016/j.bioorg.2018.04.002. [PMID: 29723744] - Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Surya P Lamichhane, Bharathi Avula, XiangDi Wang, Monica M Jablonski, Ikhlas A Khan, Soumyajit Majumdar. Retina Compatible Interactions and Effective Modulation of Blood Ocular Barrier P-gp Activity by Third-Generation Inhibitors Improve the Ocular Penetration of Loperamide.
Journal of pharmaceutical sciences.
2018 08; 107(8):2128-2135. doi:
10.1016/j.xphs.2018.04.008. [PMID: 29678592] - Colin Reily, Dana V Rizk, Bruce A Julian, Jan Novak. Assay for galactose-deficient IgA1 enables mechanistic studies with primary cells from IgA nephropathy patients.
BioTechniques.
2018 Aug; 65(2):71-77. doi:
10.2144/btn-2018-0042. [PMID: 30091383] - Kitiya Piboonprai, Phattharachanok Khumkhrong, Mattaka Khongkow, Teerapong Yata, Nijsiri Ruangrungsi, Chaisak Chansriniyom, Tawin Iempridee. Anticancer activity of arborinine from Glycosmis parva leaf extract in human cervical cancer cells.
Biochemical and biophysical research communications.
2018 06; 500(4):866-872. doi:
10.1016/j.bbrc.2018.04.175. [PMID: 29705700] - Remy B Verheijen, Maqsood Yaqub, Emilia Sawicki, Olaf van Tellingen, Adriaan A Lammertsma, Bastiaan Nuijen, Jan H M Schellens, Jos H Beijnen, Alwin D R Huitema, N Harry Hendrikse, Neeltje Steeghs. Molecular Imaging of ABCB1 and ABCG2 Inhibition at the Human Blood-Brain Barrier Using Elacridar and 11C-Erlotinib PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2018 06; 59(6):973-979. doi:
10.2967/jnumed.117.195800. [PMID: 29175983] - Sébastien Goutal, Oliver Langer, Sylvain Auvity, Karine Andrieux, Christine Coulon, Fabien Caillé, Philippe Gervais, Salvatore Cisternino, Xavier Declèves, Nicolas Tournier. Intravenous infusion for the controlled exposure to the dual ABCB1 and ABCG2 inhibitor elacridar in nonhuman primates.
Drug delivery and translational research.
2018 06; 8(3):536-542. doi:
10.1007/s13346-017-0472-6. [PMID: 29294257] - Niggula Praveen Kumar, Pankaj Sharma, T Srinivasa Reddy, Nagula Shankaraiah, Suresh K Bhargava, Ahmed Kamal. Microwave-assisted one-pot synthesis of new phenanthrene fused-tetrahydrodibenzo-acridinones as potential cytotoxic and apoptosis inducing agents.
European journal of medicinal chemistry.
2018 May; 151(?):173-185. doi:
10.1016/j.ejmech.2018.03.069. [PMID: 29609122] - Tanmoy Sadhukha, Buddhadev Layek, Swayam Prabha. Incorporation of lipolysis in monolayer permeability studies of lipid-based oral drug delivery systems.
Drug delivery and translational research.
2018 04; 8(2):375-386. doi:
10.1007/s13346-017-0383-6. [PMID: 28462499] - Veronika Brixner, Arndt-Holger Kiessling, Katharina Madlener, Markus M Müller, Johannes Leibacher, Sarah Dombos, Iuliia Weber, Hans-Ulrich Pfeiffer, Christof Geisen, Michael Schmidt, Reinhard Henschler, Anne North, Norman Huang, Nina Mufti, Anna Erickson, Christine Ernst, Salvador Rico, Richard J Benjamin, Laurence M Corash, Erhard Seifried. Red blood cells treated with the amustaline (S-303) pathogen reduction system: a transfusion study in cardiac surgery.
Transfusion.
2018 04; 58(4):905-916. doi:
10.1111/trf.14528. [PMID: 29498049] - M Aubry, A Laughhunn, F Santa Maria, M C Lanteri, A Stassinopoulos, D Musso. Amustaline (S-303) treatment inactivates high levels of Chikungunya virus in red-blood-cell components.
Vox sanguinis.
2018 Apr; 113(3):232-241. doi:
10.1111/vox.12626. [PMID: 29314033] - Lina Al-Akra, Dong-Hun Bae, Sumit Sahni, Michael L H Huang, Kyung Chan Park, Darius J R Lane, Patric J Jansson, Des R Richardson. Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.
The Journal of biological chemistry.
2018 03; 293(10):3562-3587. doi:
10.1074/jbc.m116.772699. [PMID: 29305422] - Maite Aubry, Andrew Laughhunn, Felicia Santa Maria, Marion C Lanteri, Adonis Stassinopoulos, Didier Musso. Pathogen inactivation of Dengue virus in red blood cells using amustaline and glutathione.
Transfusion.
2017 12; 57(12):2888-2896. doi:
10.1111/trf.14318. [PMID: 28921542] - Anuradha Sharma, Poonam Piplani. Design and synthesis of some acridine-piperazine hybrids for the improvement of cognitive dysfunction.
Chemical biology & drug design.
2017 Nov; 90(5):926-935. doi:
10.1111/cbdd.13017. [PMID: 28544619] - Hong-Ying Ma, Jia-Da Yang, Jie Hou, Li-Wei Zou, Qiang Jin, Da-Cheng Hao, Jing Ning, Guang-Bo Ge, Ling Yang. Comparative metabolism of DDAO benzoate in liver microsomes from various species.
Toxicology in vitro : an international journal published in association with BIBRA.
2017 Oct; 44(?):280-286. doi:
10.1016/j.tiv.2017.06.020. [PMID: 28647665] - Kayoko Kanamitsu, Hiroyuki Kusuhara, John D Schuetz, Kenji Takeuchi, Yuichi Sugiyama. Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.
Journal of pharmaceutical sciences.
2017 09; 106(9):2566-2575. doi:
10.1016/j.xphs.2017.04.040. [PMID: 28456721] - Ken-Ichi Fujita, Yusuke Masuo, Erina Yamazaki, Toshiki Shibutani, Yutaro Kubota, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites.
Journal of pharmaceutical sciences.
2017 09; 106(9):2632-2641. doi:
10.1016/j.xphs.2017.04.064. [PMID: 28479358] - Mariagrazia Iacomino, Fabian Weber, Maike Gleichenhagen, Valeria Pistorio, Lucia Panzella, Elio Pizzo, Andreas Schieber, Marco d'Ischia, Alessandra Napolitano. Stable Benzacridine Pigments by Oxidative Coupling of Chlorogenic Acid with Amino Acids and Proteins: Toward Natural Product-Based Green Food Coloring.
Journal of agricultural and food chemistry.
2017 Aug; 65(31):6519-6528. doi:
10.1021/acs.jafc.7b00999. [PMID: 28488442] - Nobuko Hada, William Joseph Netzer, Fanny Belhassan, Lawrence Paul Wennogle, Sveinbjörn Gizurarson. Nose-to-brain transport of imatinib mesylate: A pharmacokinetic evaluation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 May; 102(?):46-54. doi:
10.1016/j.ejps.2017.02.032. [PMID: 28238945] - Ye Zheng, Cale D Fahrenholtz, Christopher L Hackett, Song Ding, Cynthia S Day, Rohan Dhall, Glen S Marrs, Michael D Gross, Ravi Singh, Ulrich Bierbach. Large-Pore Functionalized Mesoporous Silica Nanoparticles as Drug Delivery Vector for a Highly Cytotoxic Hybrid Platinum-Acridine Anticancer Agent.
Chemistry (Weinheim an der Bergstrasse, Germany).
2017 Mar; 23(14):3386-3397. doi:
10.1002/chem.201604868. [PMID: 28122141] - Muhammad Saqib, Baohua Lou, Mohamed Ibrahim Halawa, Shimeles Addisu Kitte, Zhongyuan Liu, Guobao Xu. Chemiluminescence of Lucigenin-Allantoin and Its Application for the Detection of Allantoin.
Analytical chemistry.
2017 02; 89(3):1863-1869. doi:
10.1021/acs.analchem.6b04271. [PMID: 28208242] - Ângela Almeida, Vânia Calisto, M Rosário M Domingues, Valdemar I Esteves, Rudolf J Schneider, Amadeu M V M Soares, Etelvina Figueira, Rosa Freitas. Comparison of the toxicological impacts of carbamazepine and a mixture of its photodegradation products in Scrobicularia plana.
Journal of hazardous materials.
2017 Feb; 323(Pt A):220-232. doi:
10.1016/j.jhazmat.2016.05.009. [PMID: 27217301] - Yutaka Yonezawa, Taishi Miyashita, Hiroko Ashizawa, Kazuto Hashimoto, Hiroaki Nejishima, Haruko Ogawa. Evaluation of a general toxicity study incorporating phototoxicity assessments in Sprague-Dawley rats.
The Journal of toxicological sciences.
2017; 42(2):145-157. doi:
10.2131/jts.42.145. [PMID: 28321041] - Nicolas Tournier, Sebastien Goutal, Sylvain Auvity, Alexander Traxl, Severin Mairinger, Thomas Wanek, Ourkia-Badia Helal, Irène Buvat, Michael Soussan, Fabien Caillé, Oliver Langer. Strategies to Inhibit ABCB1- and ABCG2-Mediated Efflux Transport of Erlotinib at the Blood-Brain Barrier: A PET Study on Nonhuman Primates.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2017 Jan; 58(1):117-122. doi:
10.2967/jnumed.116.178665. [PMID: 27493269] - Sinara Mônica Vitalino de Almeida, Lúcia Patrícia Bezerra Gomes da Silva, Luiza Rayanna Amorim de Lima, Giovanna Barbarini Longato, Rafael José Ribeiro Padilha, Luiz Carlos Alves, Fábio André Brayner, Ana Lucia Tasca Gois Ruiz, João Ernesto de Carvalho, Eduardo Isidoro Carneiro Beltrão, Maria do Carmo Alves de Lima, Luiz Bezerra de Carvalho Júnior. Ultrastructural Assessment of 2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide activity on human breast adenocarcinoma cells.
Micron (Oxford, England : 1993).
2016 Nov; 90(?):114-122. doi:
10.1016/j.micron.2016.08.009. [PMID: 27668344] - Swaroop Kumar Pandey, Subhasish Biswas, Sarika Gunjan, Bhavana Singh Chauhan, Sunil Kumar Singh, Kumkum Srivastava, Sarika Singh, Sanjay Batra, Renu Tripathi. Pyrrolidine-Acridine hybrid in Artemisinin-based combination: a pharmacodynamic study.
Parasitology.
2016 09; 143(11):1421-32. doi:
10.1017/s0031182016000937. [PMID: 27230403] - Takaomi Shimokawa, Hidenobu Tsutsui, Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Masashi Takama, Shuhei Yoshida, Takao Tanba, Ayumi Tojo, Masayo Yamagata, Tokihito Yukimura. Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through α2C-adrenoceptors in rats.
European journal of pharmacology.
2016 Jun; 781(?):36-44. doi:
10.1016/j.ejphar.2016.03.059. [PMID: 27041645] - Ryota Takeuchi, Kohki Shinozaki, Takeo Nakanishi, Ikumi Tamai. Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart.
Drug metabolism and disposition: the biological fate of chemicals.
2016 Jan; 44(1):68-74. doi:
10.1124/dmd.115.066654. [PMID: 26467765] - Zuzana Neumanova, Lukas Cerveny, Martina Ceckova, Frantisek Staud. Role of ABCB1, ABCG2, ABCC2 and ABCC5 transporters in placental passage of zidovudine.
Biopharmaceutics & drug disposition.
2016 Jan; 37(1):28-38. doi:
10.1002/bdd.1993. [PMID: 26390406] - Rita Nieto Montesinos, Arnaud Béduneau, Alf Lamprecht, Yann Pellequer. Liposomes Coloaded with Elacridar and Tariquidar To Modulate the P-Glycoprotein at the Blood-Brain Barrier.
Molecular pharmaceutics.
2015 Nov; 12(11):3829-38. doi:
10.1021/acs.molpharmaceut.5b00002. [PMID: 26390138] - Karen E Parrish, Jenny Pokorny, Rajendar K Mittapalli, Katrina Bakken, Jann N Sarkaria, William F Elmquist. Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model.
The Journal of pharmacology and experimental therapeutics.
2015 Nov; 355(2):264-71. doi:
10.1124/jpet.115.228213. [PMID: 26354993] - Medine Gulluce, Furkan Orhan, Derya Yanmis, Tulin Arasoglu, Zuhal Guvenalp, Lutfiye Omur Demirezer. Isolation of a flavonoid, apigenin 7-O-glucoside, from Mentha longifolia (L.) Hudson subspecies longifolia and its genotoxic potency.
Toxicology and industrial health.
2015 Sep; 31(9):831-40. doi:
10.1177/0748233713475511. [PMID: 23377117] - Rania Nasrallah, Ramzi Hassouneh, Joseph Zimpelmann, Andrew J Karam, Jean-Francois Thibodeau, Dylan Burger, Kevin D Burns, Chris Rj Kennedy, Richard L Hébert. Prostaglandin E2 increases proximal tubule fluid reabsorption, and modulates cultured proximal tubule cell responses via EP1 and EP4 receptors.
Laboratory investigation; a journal of technical methods and pathology.
2015 Sep; 95(9):1044-55. doi:
10.1038/labinvest.2015.79. [PMID: 26121313] - Tahereh Khajvand, Olia Alijanpour, Mohammad Javad Chaichi, Majid Vafaeezadeh, Mohammad Mahmoodi Hashemi. Imidazolium-based ionic liquid derivative/Cu(II) complexes as efficient catalysts of the lucigenin chemiluminescence system and its application to H2O 2 and glucose detection.
Analytical and bioanalytical chemistry.
2015 Aug; 407(20):6127-36. doi:
10.1007/s00216-015-8795-y. [PMID: 26163131] - Ping Liu, Yongjun Hu, Jiaxin Chen, Qing Yang. Direct detection of the anti-cancer drug 9-phenylacridine in tissues by graphite rod laser desorption vacuum-ultraviolet post-ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2015 Jul; 29(14):1328-34. doi:
10.1002/rcm.7226. [PMID: 26405794] - Tsuyoshi Karibe, Rie Hagihara-Nakagomi, Koji Abe, Tomoki Imaoka, Tsuyoshi Mikkaichi, Satoru Yasuda, Masakazu Hirouchi, Nobuaki Watanabe, Noriko Okudaira, Takashi Izumi. Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP modulation on the pharmacokinetics of BCRP substrates.
Pharmaceutical research.
2015 May; 32(5):1634-47. doi:
10.1007/s11095-014-1563-4. [PMID: 25380981] - Zulipiyan Abulimite, Xiaojing Mu, Shangyou Xiao, Min Liu, Quandan Li, Gang Chen. New chemiluminescent substrates of paraoxonase 1 with improved specificity: synthesis and properties.
Applied biochemistry and biotechnology.
2015 May; 176(1):301-16. doi:
10.1007/s12010-015-1575-5. [PMID: 25809994] - Hiromi Sato, Sana Siddig, Miaki Uzu, Sayumi Suzuki, Yuki Nomura, Tatsuro Kashiba, Keisuke Gushimiyagi, Yuko Sekine, Tomoya Uehara, Yasushi Arano, Katsunori Yamaura, Koichi Ueno. Elacridar enhances the cytotoxic effects of sunitinib and prevents multidrug resistance in renal carcinoma cells.
European journal of pharmacology.
2015 Jan; 746(?):258-66. doi:
10.1016/j.ejphar.2014.11.021. [PMID: 25455500] - Ana I Loureiro, Maria João Bonifácio, Carlos Fernandes-Lopes, Nuno Pires, Bruno Igreja, Lyndon C Wright, Patrício Soares-da-Silva. Role of P-glycoprotein and permeability upon the brain distribution and pharmacodynamics of etamicastat: a comparison with nepicastat.
Xenobiotica; the fate of foreign compounds in biological systems.
2015; 45(9):828-39. doi:
10.3109/00498254.2015.1018985. [PMID: 25915108] - Zheyi Hu, Zaigang Zhou, Yahui Hu, Jinhui Wu, Yunman Li, Wenlong Huang. HZ08 reverse P-glycoprotein mediated multidrug resistance in vitro and in vivo.
PloS one.
2015; 10(2):e0116886. doi:
10.1371/journal.pone.0116886. [PMID: 25689592] - Victor Kuete, Louis P Sandjo, Jackson A Seukep, Maen Zeino, Armelle T Mbaveng, Bonaventure Ngadjui, Thomas Efferth. Cytotoxic compounds from the fruits of Uapaca togoensis towards multifactorial drug-resistant cancer cells.
Planta medica.
2015 Jan; 81(1):32-8. doi:
10.1055/s-0034-1383362. [PMID: 25473921] - V V Stelmah, V K Kozlov, A N Nekrasova. [Kinetics of Virus Load HCV-RNA in Blood Serum and Peripheral Mononuclear Cells in a Patient with Hepatocirrhosis and Chronic Virus Hepatitis C Termination Treated According to Noninterferon Treatment Scheme (Cycloferon + Ribavirin)].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic].
2015; 60(3-4):24-30. doi:
NULL. [PMID: 26415380] - Fei Liu, Xiaoqing Wang, Zheng Li, Jin Li, Xiaomei Zhuang, Zhenqing Zhang. P-Glycoprotein (ABCB1) limits the brain distribution of YQA-14, a novel dopamine D3 receptor antagonist.
Chemical & pharmaceutical bulletin.
2015; 63(7):512-8. doi:
10.1248/cpb.c15-00089. [PMID: 26133067] - Lingfeng Gao, Hongli Zhang, Hua Cui. A general strategy to prepare homogeneous and reagentless GO/lucigenin&enzyme biosensors for detection of small biomolecules.
Biosensors & bioelectronics.
2014 Jul; 57(?):65-70. doi:
10.1016/j.bios.2014.01.057. [PMID: 24549137] - I F Tereshina, I I Kut'ko, G S Rachkauskas. [INFLUENCE OF REAMBERIN® AND CYCLOFERON® ON CONCETRATION OF 'AVERAGE MOLECULES' IN SERUM OF PATIENTS WITH RECCURENT DEPRESSIVE DISORDERS IN OUTPATIENT OBSERVATION].
Likars'ka sprava.
2014 Jul; ?(7-8):93-8. doi:
NULL. [PMID: 26118092] - Xianyong Yu, Zhixi Liao, Qing Yao, Heting Liu, Wenlin Xie. Spectroscopic studies on the interaction of Phacolysin and bovine serum albumin.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014 Jun; 127(?):231-6. doi:
10.1016/j.saa.2014.02.064. [PMID: 24632176] - Hidetoshi Arakawa, Keiko Tsuruoka, Ken-ichi Ohno, Noriko Tajima, Hiromi Nagano. Development of a highly sensitive chemiluminescent assay for hydrogen peroxide under neutral conditions using acridinium ester and its application to an enzyme immunoassay.
Luminescence : the journal of biological and chemical luminescence.
2014 Jun; 29(4):374-7. doi:
10.1002/bio.2555. [PMID: 23832789] - J J M A Hendrikx, J S Lagas, E Wagenaar, H Rosing, J H M Schellens, J H Beijnen, A H Schinkel. Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation.
British journal of cancer.
2014 May; 110(11):2669-76. doi:
10.1038/bjc.2014.222. [PMID: 24781280] - Fan Lin, Mark C de Gooijer, Eloy Moreno Roig, Levi C M Buil, Susan M Christner, Jan H Beumer, Thomas Würdinger, Jos H Beijnen, Olaf van Tellingen. ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014 May; 20(10):2703-13. doi:
10.1158/1078-0432.ccr-14-0084. [PMID: 24647572] - Zuorong Wang, Huan Yue, Yonghong Wang, Lin Wang, Zhifeng Fu. A highly sensitive CE-chemiluminescence method for the determination of sympathomimetic drugs in urine samples by a facile precolumn derivatization using acridinium ester.
Electrophoresis.
2014 Apr; 35(7):1000-3. doi:
10.1002/elps.201300314. [PMID: 24812684] - Seng Chuan Tang, Luan N Nguyen, Rolf W Sparidans, Els Wagenaar, Jos H Beijnen, Alfred H Schinkel. Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.
International journal of cancer.
2014 Mar; 134(6):1484-94. doi:
10.1002/ijc.28475. [PMID: 24037730] - N S Pravada, A M Budritskiĭ, D S Sukhanov. [Meglumine acridonacetate and complex therapy of patients with newly identified advanced pulmonary tuberculosis].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic].
2014; 59(5-6):15-9. doi:
NULL. [PMID: 25552039] - Tsai-Hsia Hong, Shuenn-Wen Kuo, Fu-Chang Hu, Wen-Je Ko, Li-Ming Hsu, Shu-Chien Huang, Ya-Wen Yang, Sung-Liang Yu, Yih-Sharng Chen. Do interleukin-10 and superoxide ions predict outcomes of cardiac extracorporeal membrane oxygenation patients?.
Antioxidants & redox signaling.
2014 Jan; 20(1):60-8. doi:
10.1089/ars.2013.5427. [PMID: 23786249] - A V Voronkov, I N D'iakova, Iu A Ogurtsov, Iu Iu Zhidkova, O Iu Gamzeleva. [Study of the influence of original multicomponent gels on the process of pathological scar formation using new methodological approach].
Eksperimental'naia i klinicheskaia farmakologiia.
2014; 77(9):38-42. doi:
". [PMID: 25365869] - M G Romantsov, I M Lysenko, I Iu Mel'nikova. [Pharmacological prophylaxis and treatment of recidivating respiratory disorders in children].
Eksperimental'naia i klinicheskaia farmakologiia.
2014; 77(1):38-42. doi:
NULL. [PMID: 24649601] - Jian Shi, Bei Cao, Wei-Bin Zha, Xiao-Lan Wu, Lin-Sheng Liu, Wen-Jing Xiao, Rong-Rong Gu, Run-Bin Sun, Xiao-Yi Yu, Tian Zheng, Meng-Jie Li, Xin-Wen Wang, Jun Zhou, Yong Mao, Chun Ge, Ting Ma, Wen-Juan Xia, Ji-Ye Aa, Guang-Ji Wang, Chang-Xiao Liu. Pharmacokinetic interactions between 20(S)-ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo.
Acta pharmacologica Sinica.
2013 Oct; 34(10):1349-58. doi:
10.1038/aps.2013.69. [PMID: 23892274] - Uraiwan Phetkul, Nutthakran Wanlaso, Wilawan Mahabusarakam, Souwalak Phongpaichit, Anthony R Carroll. New acridone from the wood of Citrus reticulata Blanco.
Natural product research.
2013 Oct; 27(20):1922-6. doi:
10.1080/14786419.2013.793687. [PMID: 23697332] - Nicolas Tournier, Wadad Saba, Salvatore Cisternino, Marie-Anne Peyronneau, Annelaure Damont, Sébastien Goutal, Albertine Dubois, Frédéric Dollé, Jean-Michel Scherrmann, Héric Valette, Bertrand Kuhnast, Michel Bottlaender. Effects of selected OATP and/or ABC transporter inhibitors on the brain and whole-body distribution of glyburide.
The AAPS journal.
2013 Oct; 15(4):1082-90. doi:
10.1208/s12248-013-9514-2. [PMID: 23907487] - Julia Müllauer, Rudolf Karch, Jens P Bankstahl, Marion Bankstahl, Johann Stanek, Thomas Wanek, Severin Mairinger, Markus Müller, Wolfgang Löscher, Oliver Langer, Claudia Kuntner. Assessment of cerebral P-glycoprotein expression and function with PET by combined [11C]inhibitor and [11C]substrate scans in rats.
Nuclear medicine and biology.
2013 Aug; 40(6):755-63. doi:
10.1016/j.nucmedbio.2013.05.005. [PMID: 23774004]
