Trientine (BioDeep_00001867731)
Main id: BioDeep_00000003485
代谢物信息卡片
TRIETHYLENETETRAMINE
化学式: C6H18N4 (146.1531388)
中文名称: 三亚乙基四胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CNCCNCCN)N
InChI: InChI=1S/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2
描述信息
A - Alimentary tract and metabolism > A16 - Other alimentary tract and metabolism products > A16A - Other alimentary tract and metabolism products > A16AX - Various alimentary tract and metabolism products
D064449 - Sequestering Agents > D002614 - Chelating Agents
同义名列表
2 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:39501
- KEGG: C07166
- PubChem: 5565
- DrugBank: DB06824
- ChEMBL: CHEMBL609
- MeSH: Trientine
- CAS: 105821-86-1
- CAS: 112-24-3
- PubChem: 9375
- PDB-CCD: 104
- NIKKAJI: J5.120I
- RefMet: Trientine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ziwei Zhu, Turak Ablajan, Deng Zang, Haji Akber Aisa. Guaianolide sesquiterpenes and their activity from Artemisia mongolica.
Phytochemistry.
2024 Apr; 220(?):114019. doi:
10.1016/j.phytochem.2024.114019. [PMID: 38346546] - Umair Khurshid, Saeed Ahmad, Hammad Saleem, Arslan Hussain LodhI, Irfan Pervaiz, Mohsin Abbas Khan, Haroon Khan, Abdulwahab AlamrI, Mukhtar AnsarI, Marcello LocatellI, Muhammad Adeel Arshad, Muhammad Asif Wazir, Juwairiya Butt, Sirajudheen Anwar. Multifaced Assessment of Antioxidant Power, Phytochemical Metabolomics, In-Vitro Biological Potential and In-Silico Studies of Neurada procumbens L.: An Important Medicinal Plant.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185849. [PMID: 36144585] - Anna Reid, Christopher Miller, John Peter Farrant, Rahul Polturi, David Clark, Simon Ray, Garth Cooper, Matthias Schmitt. Copper chelation in patients with hypertrophic cardiomyopathy.
Open heart.
2022 02; 9(1):. doi:
10.1136/openhrt-2021-001803. [PMID: 35169044] - Sanjay Kumar, Biswa Ranjan Patra, Mohammed Irtaza, Praveen Kumar Rao, Suprabhat Giri, Harish Darak, Amrit Gopan, Aditya Kale, Akash Shukla. Adverse Events with D-penicillamine Therapy in Hepatic Wilson's Disease: A Single-Center Retrospective Audit.
Clinical drug investigation.
2022 Feb; 42(2):177-184. doi:
10.1007/s40261-022-01117-x. [PMID: 35102516] - Karl Heinz Weiss, Catherine Thompson, Peter Dogterom, Yi-Jin Chiou, Tim Morley, Brinley Jackson, Naseem Amin, Camille Omar Farouk Kamlin. Comparison of the Pharmacokinetic Profiles of Trientine Tetrahydrochloride and Trientine Dihydrochloride in Healthy Subjects.
European journal of drug metabolism and pharmacokinetics.
2021 Sep; 46(5):665-675. doi:
10.1007/s13318-021-00704-1. [PMID: 34357516] - Vitaly D Samuilov, Dmitry B Kiselevsky, Elena V Dzyubinskaya, Olga Yu Frolova. Effects of Superoxide Dismutase Inhibitors and Glucose on Cell Death and Generation of Reactive Oxygen Species in Pea Leaves.
Biochemistry. Biokhimiia.
2021 Jul; 86(7):878-886. doi:
10.1134/s0006297921070087. [PMID: 34284711] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Francesca Castoldi, Mervi T Hyvönen, Sylvère Durand, Fanny Aprahamian, Allan Sauvat, Shoaib A Malik, Elisa Elena Baracco, Erika Vacchelli, Paule Opolon, Nicolas Signolle, Déborah Lefevre, Noelie Bossut, Tobias Eisenberg, Christopher Dammbrueck, Tobias Pendl, Margerie Kremer, Sylvie Lachkar, Claudia Einer, Bernhard Michalke, Hans Zischka, Frank Madeo, Tuomo A Keinänen, Maria Chiara Maiuri, Federico Pietrocola, Guido Kroemer. Chemical activation of SAT1 corrects diet-induced metabolic syndrome.
Cell death and differentiation.
2020 10; 27(10):2904-2920. doi:
10.1038/s41418-020-0550-z. [PMID: 32376874] - Marcia Leung, Jaimie Wu Lanzafame, Valentina Medici. Switching Pharmacological Treatment in Wilson Disease: Case Report and Recommendations.
Journal of investigative medicine high impact case reports.
2020 Jan; 8(?):2324709619896876. doi:
10.1177/2324709619896876. [PMID: 31920114] - Lidong Wang, Shanshan Liu, Rujie Wang, Qiangwei Li, Shihan Zhang. Regulating Phase Separation Behavior of a DEEA-TETA Biphasic Solvent Using Sulfolane for Energy-Saving CO2 Capture.
Environmental science & technology.
2019 Nov; 53(21):12873-12881. doi:
10.1021/acs.est.9b02787. [PMID: 31446756] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Norikazu Shimizu. [Diagnosis and treatment of Wilson disease in Japan].
Rinsho shinkeigaku = Clinical neurology.
2019 Sep; 59(9):565-569. doi:
10.5692/clinicalneurol.cn-001241. [PMID: 31474637] - Chunyan Fu, Junhong Lizhao, Zhenghui Luo, Tao Wang, Craig A Grapperhaus, Xueqin Ding, Y James Kang. Active uptake of hydrophilic copper complex Cu(ii)-TETA in primary cultures of neonatal rat cardiomyocytes.
Metallomics : integrated biometal science.
2019 03; 11(3):565-575. doi:
10.1039/c8mt00277k. [PMID: 30761393] - Jan Pfeiffenberger, Christine Marie Lohse, Daniel Gotthardt, Christian Rupp, Markus Weiler, Ulrike Teufel, Karl Heinz Weiss, Annika Gauss. Long-term evaluation of urinary copper excretion and non-caeruloplasmin associated copper in Wilson disease patients under medical treatment.
Journal of inherited metabolic disease.
2019 03; 42(2):371-380. doi:
10.1002/jimd.12046. [PMID: 30746719] - Yoshinosuke Shimamura, Takuto Maeda, Yufu Gocho, Yayoi Ogawa, Kunihiko Tsuji, Hideki Takizawa. Immunoglobulin A nephropathy secondary to Wilson's disease: a case report and literature review.
CEN case reports.
2019 02; 8(1):61-66. doi:
10.1007/s13730-018-0365-7. [PMID: 30255238] - Riikka Gunnar, Mirka Lumia, Mikko Pakarinen, Laura Merras-Salmio. Children With Intestinal Failure Undergoing Intestinal Rehabilitation Are at Risk for Essential Fatty Acid Deficiency.
JPEN. Journal of parenteral and enteral nutrition.
2018 09; 42(7):1203-1210. doi:
10.1002/jpen.1152. [PMID: 29701873] - Jan Pfeiffenberger, Carlot Kruse, Peter Mutch, Andrew Harker, Karl Heinz Weiss. The steady state pharmacokinetics of trientine in Wilson disease patients.
European journal of clinical pharmacology.
2018 Jun; 74(6):731-736. doi:
10.1007/s00228-018-2424-6. [PMID: 29417175] - Lianlian Wang, Xiaofang Luo, Cong Li, Yubing Huang, Ping Xu, Laetitia H Lloyd-Davies, Thibaut Delplancke, Chuan Peng, Rufei Gao, Hongbo Qi, Chao Tong, Philip Baker. Triethylenetetramine Synergizes with Pharmacologic Ascorbic Acid in Hydrogen Peroxide Mediated Selective Toxicity to Breast Cancer Cell.
Oxidative medicine and cellular longevity.
2017; 2017(?):3481710. doi:
10.1155/2017/3481710. [PMID: 28280522] - Ji-Ming Yin, Li-Bo Sun, Jia-Sheng Zheng, Xin-Xin Wang, De-Xi Chen, Ning Li. Copper chelation by trientine dihydrochloride inhibits liver RFA-induced inflammatory responses in vivo.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2016 Dec; 65(12):1009-1020. doi:
10.1007/s00011-016-0986-2. [PMID: 27613237] - Robin Tremmel, Philipp Uhl, Frieder Helm, Dominik Wupperfeld, Max Sauter, Walter Mier, Wolfgang Stremmel, Götz Hofhaus, Gert Fricker. Delivery of Copper-chelating Trientine (TETA) to the central nervous system by surface modified liposomes.
International journal of pharmaceutics.
2016 Oct; 512(1):87-95. doi:
10.1016/j.ijpharm.2016.08.040. [PMID: 27553779] - Jennifer Nayor, Anand Vaidya, Amitabh Srivastava, Julian L Seifter, Anna E Rutherford. INTERACTIVE MEDICAL CASE. Tracing the Cause of Abdominal Pain.
The New England journal of medicine.
2016 Aug; 375(6):e8. doi:
10.1056/nejmimc1512611. [PMID: 27509123] - Wen-Jie Li, Chen Chen, Zhi-Fei You, Ren-Min Yang, Xiao-Ping Wang. Current Drug Managements of Wilson's Disease: From West to East.
Current neuropharmacology.
2016; 14(4):322-5. doi:
10.2174/1570159x14666151130222427. [PMID: 26639459] - Raoul Santiago, Frédéric Gottrand, Dominique Debray, Laure Bridoux, Alain Lachaux, Alain Morali, Delphine Lapeyre, Thierry Lamireau. Zinc Therapy for Wilson Disease in Children in French Pediatric Centers.
Journal of pediatric gastroenterology and nutrition.
2015 Dec; 61(6):613-8. doi:
10.1097/mpg.0000000000000926. [PMID: 26230903] - Sebastian Brings, Shaoping Zhang, Yee S Choong, Sebastian Hogl, Martin Middleditch, Meder Kamalov, Margaret A Brimble, Deming Gong, Garth J S Cooper. Diabetes-induced alterations in tissue collagen and carboxymethyllysine in rat kidneys: Association with increased collagen-degrading proteinases and amelioration by Cu(II)-selective chelation.
Biochimica et biophysica acta.
2015 Aug; 1852(8):1610-8. doi:
10.1016/j.bbadis.2015.04.014. [PMID: 25900786] - Aftab Ala, Ermal Aliu, Michael L Schilsky. Prospective pilot study of a single daily dosage of trientine for the treatment of Wilson disease.
Digestive diseases and sciences.
2015 May; 60(5):1433-9. doi:
10.1007/s10620-014-3495-6. [PMID: 25605552] - Kathleen E Dennis, William M Valentine. Ziram and sodium N,N-dimethyldithiocarbamate inhibit ubiquitin activation through intracellular metal transport and increased oxidative stress in HEK293 cells.
Chemical research in toxicology.
2015 Apr; 28(4):682-90. doi:
10.1021/tx500450x. [PMID: 25714994] - Yang Cao, Marit Aralt Skaug, Ole Andersen, Jan Aaseth. Chelation therapy in intoxications with mercury, lead and copper.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2015; 31(?):188-92. doi:
10.1016/j.jtemb.2014.04.010. [PMID: 24894443] - Nobuo Uehara, Yoshikuni Numanami, Toru Oba, Noriyuki Onishi, Xiaomao Xie. Thermal-induced Immuno-nephelometry Using Gold Nanoparticles Conjugated with a Thermoresponsive Polymer for the Detection of Avidin.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2015; 31(6):495-501. doi:
10.2116/analsci.31.495. [PMID: 26063011] - Dandan Jia, Lei Cao, Dongni Wang, Xuemin Guo, He Liang, Fangfang Zhao, Yaohang Gu, Dongjun Wang. Uncovering a broad class of fluorescent amine-containing compounds by heat treatment.
Chemical communications (Cambridge, England).
2014 Oct; 50(78):11488-91. doi:
10.1039/c4cc05342g. [PMID: 25132137] - Jana Mattová, Pavla Poučková, Jan Kučka, Michaela Skodová, Miroslav Vetrík, Petr Stěpánek, Petr Urbánek, Miloš Petřík, Zbyněk Nový, Martin Hrubý. Chelating polymeric beads as potential therapeutics for Wilson's disease.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Oct; 62(?):1-7. doi:
10.1016/j.ejps.2014.05.002. [PMID: 24815561] - Bui The Huy, Avvaru Praveen Kumar, Min-Ho Seo, Jan-Di Kim, Yong-Ill Lee. Controllable synthesis of thiol-capped CdTe nanoparticles for optical sensing of triethylenetetramine dihydrochloride.
Journal of nanoscience and nanotechnology.
2014 Oct; 14(10):7662-7. doi:
10.1166/jnn.2014.9423. [PMID: 25942844] - Daniel P Hunt, Dushyant V Sahani, Kathleen E Corey, Ricard Masia. Case records of the Massachusetts General Hospital. Case 30-2014. A 29-year-old man with diarrhea, nausea, and weight loss.
The New England journal of medicine.
2014 Sep; 371(13):1238-47. doi:
10.1056/nejmcpc1405218. [PMID: 25251619] - Ali Rezaei, Esfandiar Heidarian. Co-administration of trientine and flaxseed oil on oxidative stress, serum lipids and heart structure in diabetic rats.
Indian journal of experimental biology.
2013 Aug; 51(8):646-52. doi:
. [PMID: 24228388] - Z Mareček, R Brůha. [Wilsons disease].
Vnitrni lekarstvi.
2013 Jul; 59(7):578-83. doi:
. [PMID: 23909262] - Valeria M Nurchi, Guido Crisponi, Miriam Crespo-Alonso, Joanna I Lachowicz, Zbigniew Szewczuk, Garth J S Cooper. Complex formation equilibria of Cu(II) and Zn(II) with triethylenetetramine and its mono- and di-acetyl metabolites.
Dalton transactions (Cambridge, England : 2003).
2013 May; 42(17):6161-70. doi:
10.1039/c2dt32252h. [PMID: 23202417] - Venkata K Yellepeddi, Kiran K Vangara, Ajay Kumar, Srinath Palakurthi. Comparative evaluation of small-molecule chemosensitizers in reversal of cisplatin resistance in ovarian cancer cells.
Anticancer research.
2012 Sep; 32(9):3651-8. doi:
. [PMID: 22993302] - Thomas Fröhlich, Daniel Edinger, Raphaela Kläger, Christina Troiber, Edith Salcher, Naresh Badgujar, Irene Martin, David Schaffert, Arzu Cengizeroglu, Philipp Hadwiger, Hans-Peter Vornlocher, Ernst Wagner. Structure-activity relationships of siRNA carriers based on sequence-defined oligo (ethane amino) amides.
Journal of controlled release : official journal of the Controlled Release Society.
2012 Jun; 160(3):532-41. doi:
10.1016/j.jconrel.2012.03.018. [PMID: 22465674] - J M Walshe. Serum 'free' copper in Wilson disease.
QJM : monthly journal of the Association of Physicians.
2012 May; 105(5):419-23. doi:
10.1093/qjmed/hcr229. [PMID: 22139498] - Marta Ugarte, Marie Brown, Katherine A Hollywood, Garth J Cooper, Paul N Bishop, Warwick B Dunn. Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA).
Genome medicine.
2012 Apr; 4(4):35. doi:
10.1186/gm334. [PMID: 22546713] - Tomoya Suma, Kanjiro Miyata, Takehiko Ishii, Satoshi Uchida, Hirokuni Uchida, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka. Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain.
Biomaterials.
2012 Mar; 33(9):2770-9. doi:
10.1016/j.biomaterials.2011.12.022. [PMID: 22200535] - Ding-Bang Chen, Li Feng, Xiao-Pu Lin, Wei Zhang, Fu-Rong Li, Xiu-Ling Liang, Xun-Hua Li. Penicillamine increases free copper and enhances oxidative stress in the brain of toxic milk mice.
PloS one.
2012; 7(5):e37709. doi:
10.1371/journal.pone.0037709. [PMID: 22629446] - Marc Cerrada-Gimenez, Janne Weisell, Mervi T Hyvönen, Myung Hee Park, Leena Alhonen, Jouko Vepsäläinen, Tuomo A Keinänen. Complex N-acetylation of triethylenetetramine.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Dec; 39(12):2242-9. doi:
10.1124/dmd.111.041798. [PMID: 21878558] - Leire Moya-Olano, Helen Marie Milne, Jillian Margaret Robinson, Jonathan Vernon Hill, Christopher Miles Frampton, Helen Frances Abbott, Rufus Turner, Anthony James Kettle, Zoltán Huba Endre. Trientine and renin-angiotensin system blockade ameliorate progression of glomerular morphology in hypertensive experimental diabetic nephropathy.
Pathology international.
2011 Nov; 61(11):652-61. doi:
10.1111/j.1440-1827.2011.02721.x. [PMID: 22029676] - J M Walshe. The pattern of urinary copper excretion and its response to treatment in patients with Wilson's disease.
QJM : monthly journal of the Association of Physicians.
2011 Sep; 104(9):775-8. doi:
10.1093/qjmed/hcr073. [PMID: 21622540] - Garth J S Cooper. Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease.
Drugs.
2011 Jul; 71(10):1281-320. doi:
10.2165/11591370-000000000-00000. [PMID: 21770477] - Jessica Seessle, Annina Gohdes, Daniel Nils Gotthardt, Jan Pfeiffenberger, Nicola Eckert, Wolfgang Stremmel, Ulrike Reuner, Karl Heinz Weiss. Alterations of lipid metabolism in Wilson disease.
Lipids in health and disease.
2011 May; 10(?):83. doi:
10.1186/1476-511x-10-83. [PMID: 21595966] - Yuichi Honma, Masaru Harada, Miyuki Sato, Yuka Katsuki, Masaaki Hiura, Michihiko Shibata, Ryoichi Narita, Riko Harada, Shintaro Abe, Akinari Tabaru, Nobuyoshi Tajiri, Shohei Shimajiri. Late diagnosed Wilson disease with hepatic and neurological manifestations.
Hepatology research : the official journal of the Japan Society of Hepatology.
2011 Mar; 41(3):270-6. doi:
10.1111/j.1872-034x.2010.00754.x. [PMID: 21338455] - Norikazu Shimizu, Junko Fujiwara, Shin Ohnishi, Mari Sato, Hiroko Kodama, Takao Kohsaka, Ayano Inui, Tomoo Fujisawa, Hiroshi Tamai, Shinobu Ida, Susumu Itoh, Michinori Ito, Norio Horiike, Masaru Harada, Makoto Yoshino, Tsugutoshi Aoki. Effects of long-term zinc treatment in Japanese patients with Wilson disease: efficacy, stability, and copper metabolism.
Translational research : the journal of laboratory and clinical medicine.
2010 Dec; 156(6):350-7. doi:
10.1016/j.trsl.2010.08.007. [PMID: 21078496] - M V Sholukh, A I Hubich, F S Pashkovsky, F A Lakhvich. Structural features of prostanoid analogues involved in hepatocytes protection against CCl4-induced injury.
Prostaglandins & other lipid mediators.
2010 Nov; 93(3-4):134-42. doi:
10.1016/j.prostaglandins.2010.10.001. [PMID: 20940060] - Jun Lu. Triethylenetetramine pharmacology and its clinical applications.
Molecular cancer therapeutics.
2010 Sep; 9(9):2458-67. doi:
10.1158/1535-7163.mct-10-0523. [PMID: 20660601] - Scott C Miller, Xuli Wang, Beth M Bowman. Pharmacological properties of orally available, amphipathic polyaminocarboxylic acid chelators for actinide decorporation.
Health physics.
2010 Sep; 99(3):408-12. doi:
10.1097/hp.0b013e3181bfb99b. [PMID: 20699705] - Zhiyuan Yu, Ren'an Wu, Minghuo Wu, Liang Zhao, Ruibin Li, Hanfa Zou. Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper.
Colloids and surfaces. B, Biointerfaces.
2010 Jul; 78(2):222-8. doi:
10.1016/j.colsurfb.2010.03.004. [PMID: 20381321] - J Lu, D Gong, S Y Choong, H Xu, Y-K Chan, X Chen, S Fitzpatrick, S Glyn-Jones, S Zhang, T Nakamura, K Ruggiero, V Obolonkin, S D Poppitt, A R J Phillips, G J S Cooper. Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments.
Diabetologia.
2010 Jun; 53(6):1217-26. doi:
10.1007/s00125-010-1698-8. [PMID: 20221822] - Jun Lu, Sally D Poppitt, Asma A Othman, Tracey Sunderland, Katya Ruggiero, Michael S Willett, Lisa E Diamond, Wilfredo D Garcia, Benno G Roesch, Garth J S Cooper. Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: an open-label trial.
Journal of clinical pharmacology.
2010 Jun; 50(6):647-58. doi:
10.1177/0091270009349379. [PMID: 20145262] - Hongwei Zhang, Serguei V Vinogradov. Short biodegradable polyamines for gene delivery and transfection of brain capillary endothelial cells.
Journal of controlled release : official journal of the Controlled Release Society.
2010 May; 143(3):359-66. doi:
10.1016/j.jconrel.2010.01.020. [PMID: 20093156] - Li-Ching Wang, Jiaan-Der Wang, Chi-Ren Tsai, Shao-Bin Cheng, Chieh-Chung Lin. Clinical features and therapeutic response in Taiwanese children with Wilson's disease: 12 years of experience in a single center.
Pediatrics and neonatology.
2010 Apr; 51(2):124-9. doi:
10.1016/s1875-9572(10)60022-8. [PMID: 20417464] - Tatiana G Levitskaia, Jeffrey A Creim, Terry L Curry, Teresa Luders, James E Morris, Angela D Woodstock, Barry Levinson, Karla D Thrall. Evaluation of Cuprimine and Syprine for decorporation of (60)Co and (210)Po.
Health physics.
2010 Mar; 98(3):471-9. doi:
10.1097/hp.0b013e3181bcdf4f. [PMID: 20147789] - Ming Ma, Feng Li, Fu-jie Chen, Si-xue Cheng, Ren-xi Zhuo. Poly(ethylene glycol)-block-poly(glycidyl methacrylate) with oligoamine side chains as efficient gene vectors.
Macromolecular bioscience.
2010 Feb; 10(2):183-91. doi:
10.1002/mabi.200900183. [PMID: 19771543] - Uta Merle, Karl Heinz Weiss, Christoph Eisenbach, Sabine Tuma, Peter Ferenci, Wolfgang Stremmel. Truncating mutations in the Wilson disease gene ATP7B are associated with very low serum ceruloplasmin oxidase activity and an early onset of Wilson disease.
BMC gastroenterology.
2010 Jan; 10(?):8. doi:
10.1186/1471-230x-10-8. [PMID: 20082719] - Toshiyuki Miyauchi, Yasutaka Miyachi, Makoto Takahashi, Norihisa Ishikawa, Hidehiko Mori. Determination of urea in serum based on the combination of an enzymatic reaction with immobilized urease and ion chromatographic analysis.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2010; 26(8):847-51. doi:
10.2116/analsci.26.847. [PMID: 20702937] - Y I Yarets, I A Novikova, L N Rubanov. Trien conjugates, schiff bases, and ceruloplasmin concentrations as markers of the onset of the risk of autodermoplasty complications.
Annals of burns and fire disasters.
2009 Dec; 22(4):179-84. doi:
NULL. [PMID: 21991178] - Deming Gong, Xiuyin Chen, Martin Middleditch, Liangdong Huang, Greeshma Vazhoor Amarsingh, Shiva Reddy, Jun Lu, Shaoping Zhang, Katya Ruggiero, Anthony R J Phillips, Garth J S Cooper. Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats.
Proteomics.
2009 Sep; 9(18):4309-20. doi:
10.1002/pmic.200900285. [PMID: 19634143] - George J Brewer, Fred Askari, Robert B Dick, Julia Sitterly, John K Fink, Martha Carlson, Karen J Kluin, Matthew T Lorincz. Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine.
Translational research : the journal of laboratory and clinical medicine.
2009 Aug; 154(2):70-7. doi:
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Journal of clinical pharmacology.
2009 Aug; 49(8):916-28. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2009 Jul; 137(1):54-62. doi:
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Casopis lekaru ceskych.
2009; 148(11):544-8. doi:
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Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
2008 Oct; 151(2):139-46. doi:
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Diabetologia.
2008 Sep; 51(9):1741-51. doi:
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BMC gastroenterology.
2008 Jul; 8(?):29. doi:
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Cytotechnology.
2008 Jun; 57(2):115-22. doi:
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Critical reviews in clinical laboratory sciences.
2008; 45(3):263-90. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Dec; 860(1):42-8. doi:
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Free radical biology & medicine.
2007 Dec; 43(11):1552-9. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Nov; 859(1):62-8. doi:
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The Journal of veterinary medical science.
2007 Oct; 69(10):1039-45. doi:
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Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2007 Jul; 39(7):601-9. doi:
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Hepatology research : the official journal of the Japan Society of Hepatology.
2007 Jun; 37(6):416-24. doi:
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Journal of pediatric gastroenterology and nutrition.
2007 May; 44(5):596-602. doi:
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Chemico-biological interactions.
2007 Feb; 165(3):189-99. doi:
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Lancet (London, England).
2007 Feb; 369(9559):397-408. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2007 Feb; 35(2):221-7. doi:
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Gut.
2007 Jan; 56(1):115-20. doi:
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Molecular pharmacology.
2006 Dec; 70(6):2045-51. doi:
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The Korean journal of hepatology.
2006 Sep; 12(3):333-63. doi:
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Bioconjugate chemistry.
2006 Sep; 17(5):1233-40. doi:
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Journal of agricultural and food chemistry.
2006 Mar; 54(6):2134-7. doi:
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Experimental animals.
2005 Oct; 54(5):403-12. doi:
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Medizinische Klinik (Munich, Germany : 1983).
2005 Sep; 100(9):579-82. doi:
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Diabetes.
2005 May; 54(5):1468-76. doi:
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Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2005 Apr; 12(3):303-5. doi:
10.1016/j.jocn.2004.09.005. [PMID: 15851088] - Hideaki Shimada, Makiko Takahashi, Akinori Shimada, Tadashi Okawara, Akira Yasutake, Yorishige Imamura, Morio Kiyozumi. Protection from spontaneous hepatocellular damage by N-benzyl-d-glucamine dithiocarbamate in Long-Evans Cinnamon rats, an animal model of Wilson's disease.
Toxicology and applied pharmacology.
2005 Jan; 202(1):59-67. doi:
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CNS drugs.
2005; 19(3):185-92. doi:
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Diabetes.
2004 Sep; 53(9):2501-8. doi:
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Journal of chromatography. A.
2004 Jul; 1044(1-2):177-86. doi:
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The Journal of laboratory and clinical medicine.
2004 Jun; 143(6):333-9. doi:
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Alimentary pharmacology & therapeutics.
2004 Jan; 19(2):157-65. doi:
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Bioinorganic chemistry and applications.
2004; ?(?):225-35. doi:
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Journal of drug targeting.
2004; 12(9-10):559-67. doi:
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Electrophoresis.
2003 Sep; 24(18):3181-6. doi:
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