Sulfamethizole (BioDeep_00000001824)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1-sulfonamide

化学式: C9H10N4O2S2 (270.024516)
中文名称: 磺胺甲二唑
谱图信息: 最多检出来源 Homo sapiens(blood) 1.79%

分子结构信息

SMILES: CC1=NN=C(NS(=O)(=O)C2=CC=C(N)C=C2)S1
InChI: InChI=1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13)

描述信息

Sulfamethizole is only found in individuals that have used or taken this drug. It is a sulfathiazole antibacterial agent. Sulfamethizole is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal para-aminobenzoic acid (PABA) substrate is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BA - Sulfonamides
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EB - Short-acting sulfonamides
B - Blood and blood forming organs > B05 - Blood substitutes and perfusion solutions > B05C - Irrigating solutions > B05CA - Antiinfectives
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AB - Sulfonamides
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent
D000890 - Anti-Infective Agents > D013432 - Sulfathiazoles
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
CONFIDENCE standard compound; INTERNAL_ID 1017

同义名列表

23 个代谢物同义名

4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1-sulfonamide; Wyeth brand OF sulfamethizole; Urgo brand OF sulfamethizole; FNA brand OF sulfamethizole; Sulphamethylthiadiazole; Sulfamethylthiadiazole; FNA, sulfamethizol; Sulfamethizol fna; Sulphamethizolum; Sulphamethiozole; Sulfamethizolum; Sulfamethiozole; Sulphamethazole; Sulphamethizole; sulfamethizole; Sulphamethizol; Sulfamethazole; Sulphametizol; Sulfamethizol; Sulfametizol; Thiosulphil; Thiosulfil; Rufol

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:9331
KEGG: C08050
KEGGdrug: D00870
KEGGdrug: D88000
PubChem: 5328
HMDB: HMDB0014715
Metlin: METLIN43336
DrugBank: DB00576
ChEMBL: CHEMBL1191
Wikipedia: Sulfamethizole
MeSH: Sulfamethizole
chemspider: 5137
CAS: 144-82-1
MoNA: AU101702
PMhub: MS000001237
PubChem: 10250
NIKKAJI: J4.419I
RefMet: Sulfamethizole

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Ankita Solanki, Shreya R Savla, Maheshkumar R Borkar, Lokesh K Bhatt. Sulfamethizole attenuates poloxamer 407-induced atherosclerotic neointima formation via inhibition of mTOR in C57BL/6 mice. Journal of biochemical and molecular toxicology. 2023 Feb; ?(?):e23322. doi: 10.1002/jbt.23322. [PMID: 36799065]
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