Sulfamethizole (BioDeep_00000001824)

 

Secondary id: BioDeep_00000399004

human metabolite blood metabolite Chemicals and Drugs Antibiotics natural product


代谢物信息卡片


4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1-sulfonamide

化学式: C9H10N4O2S2 (270.0245)
中文名称: 磺胺甲二唑, 磺胺甲噻二唑, 磺胺甲基咪唑
谱图信息: 最多检出来源 Homo sapiens(blood) 16.51%

分子结构信息

SMILES: CC1=NN=C(NS(=O)(=O)C2=CC=C(N)C=C2)S1
InChI: InChI=1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13)

描述信息

Sulfamethizole is only found in individuals that have used or taken this drug. It is a sulfathiazole antibacterial agent. Sulfamethizole is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. The normal para-aminobenzoic acid (PABA) substrate is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BA - Sulfonamides
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EB - Short-acting sulfonamides
B - Blood and blood forming organs > B05 - Blood substitutes and perfusion solutions > B05C - Irrigating solutions > B05CA - Antiinfectives
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AB - Sulfonamides
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent
D000890 - Anti-Infective Agents > D013432 - Sulfathiazoles
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
CONFIDENCE standard compound; INTERNAL_ID 1017

同义名列表

25 个代谢物同义名

4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1-sulfonamide; Wyeth brand OF sulfamethizole; Urgo brand OF sulfamethizole; FNA brand OF sulfamethizole; Sulphamethylthiadiazole; Sulfamethylthiadiazole; FNA, sulfamethizol; Sulfamethizol fna; Sulphamethizolum; Sulphamethiozole; Sulfamethizolum; Sulfamethiozole; Sulphamethazole; Sulphamethizole; sulfamethizole; Sulphamethizol; Sulfamethazole; Sulphametizol; Sulfamethizol; Sulfametizol; Thiosulphil; Thiosulfil; Rufol; Sulfamethizole; Sulfamethizole



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, BCL2, CYP2C9, MARK2, MTOR, PIK3CA, PIK3CG, TUBB4B, VEGFA
Peripheral membrane protein 2 CYP1B1, MTOR
Endoplasmic reticulum membrane 5 BCL2, CD4, CYP1B1, CYP2C9, MTOR
Nucleus 7 ALB, BCL2, MTOR, PARP1, PCNA, TUBB4B, VEGFA
cytosol 8 ALB, BCL2, LIPE, MTOR, PARP1, PIK3CA, PIK3CG, TUBB4B
dendrite 2 MARK2, MTOR
nuclear body 2 PARP1, PCNA
phagocytic vesicle 1 MTOR
centrosome 2 ALB, PCNA
nucleoplasm 5 FAM20C, MARK2, MTOR, PARP1, PCNA
Cell membrane 3 CD4, LIPE, PIK3CG
Cytoplasmic side 1 MTOR
lamellipodium 1 PIK3CA
Golgi apparatus membrane 2 FAM20C, MTOR
cell surface 1 VEGFA
Golgi apparatus 3 ALB, FAM20C, VEGFA
Golgi membrane 3 FAM20C, INS, MTOR
lysosomal membrane 1 MTOR
Cytoplasm, cytosol 2 LIPE, PARP1
Lysosome 1 MTOR
plasma membrane 7 CD4, CYP2C9, IFNLR1, IGHE, MARK2, PIK3CA, PIK3CG
Membrane 9 BCL2, CYP1B1, IFNLR1, LIPE, MARK2, MTOR, PARP1, PIK3CG, VEGFA
caveola 1 LIPE
extracellular exosome 4 ALB, FAM20C, PCNA, TUBB4B
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 ALB, BCL2, FAM20C, VEGFA
extracellular space 6 ALB, FAM20C, IGHE, INS, PNLIP, VEGFA
perinuclear region of cytoplasm 1 PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CYP1B1, MARK2, PARP1
protein-containing complex 3 ALB, BCL2, PARP1
intracellular membrane-bounded organelle 2 CYP1B1, CYP2C9
Microsome membrane 3 CYP1B1, CYP2C9, MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 3 CD4, IFNLR1, IGHE
Secreted 5 ALB, FAM20C, INS, PNLIP, VEGFA
extracellular region 6 ALB, IGHE, INS, PNLIP, TUBB4B, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
anchoring junction 1 ALB
transcription regulator complex 1 PARP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 CD4
Extracellular vesicle 1 TUBB4B
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 TUBB4B
nucleolus 2 PARP1, PNMA2
Early endosome 1 CD4
Single-pass type II membrane protein 1 FAM20C
Membrane raft 1 CD4
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TUBB4B
microtubule 1 TUBB4B
extracellular matrix 1 VEGFA
Nucleus, PML body 1 MTOR
PML body 1 MTOR
secretory granule 1 VEGFA
lateral plasma membrane 1 MARK2
ciliary basal body 1 ALB
chromatin 2 PARP1, PCNA
IgE immunoglobulin complex 1 IGHE
mitotic spindle 1 TUBB4B
Chromosome 1 PARP1
cytoskeleton 1 TUBB4B
centriole 1 ALB
Nucleus, nucleolus 2 PARP1, PNMA2
spindle pole 1 ALB
nuclear replication fork 2 PARP1, PCNA
chromosome, telomeric region 2 PARP1, PCNA
actin filament 1 MARK2
blood microparticle 1 ALB
[Isoform 2]: Cell membrane 1 IGHE
site of double-strand break 1 PARP1
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
nuclear envelope 2 MTOR, PARP1
Endomembrane system 1 MTOR
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
axonemal microtubule 1 TUBB4B
Cell projection, dendrite 1 MARK2
replication fork 1 PCNA
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, CD4, FAM20C, INS
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 2 ALB, VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 2 PIK3CA, PIK3CG
transport vesicle 1 INS
azurophil granule lumen 1 TUBB4B
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
nuclear lamina 1 PCNA
clathrin-coated endocytic vesicle membrane 1 CD4
protein-DNA complex 1 PARP1
Cytoplasmic vesicle, phagosome 1 MTOR
site of DNA damage 1 PARP1
[Isoform 3]: Cell membrane 1 IGHE
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
T cell receptor complex 1 CD4
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 2 PIK3CA, PIK3CG
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
microtubule bundle 1 MARK2


文献列表

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