5,8,11,14-Icosatetraenoic Acid (BioDeep_00000174775)

   

human metabolite blood metabolite natural product


代谢物信息卡片


Eicosa-5,8,11,14-tetraenoic acids

化学式: C20H32O2 (304.2402)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 42.13%

分子结构信息

SMILES: CCCCCC=CCC=CCC=CCC=CCCCC(=O)O
InChI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)

描述信息

同义名列表

15 个代谢物同义名

Eicosa-5,8,11,14-tetraenoic acids; Eicosa-5,8,11,14-tetraenoic acid; Icosa-5,8,11,14-tetraenoic acids; 5,8,11,14-Eicosatetraenoic acids; 5,8,11,14-Icosatetraenoic acids; 5E,8Z,11Z,14Z-Eicosatetraenoate; icosa-5,8,11,14-tetraenoic acid; 5,8,11,14-Eicosatetraenoic acid; 5,8,11,14-Icosatetraenoic Acid; Eicosa-5,8,11,14-tetraenoate; Icosa-5,8,11,14-tetraenoate; 5,8,11,14-Eicosatetraenoate; 5,8,11,14-Icosatetraenoate; C20:4, N-6,9,12,15; 5,8,11,14-20:4



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

57 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALOX5, CAT, PLA2G12A, PLA2G6, PPARG, XDH
Peripheral membrane protein 1 ALOX5
Endosome membrane 2 CD14, TF
Nucleus 4 LMNA, PLCZ1, PPARA, PPARG
cytosol 8 ALOX5, CAT, LIPE, LMNA, PLA2G6, PLCZ1, PPARG, XDH
nucleoplasm 5 ALOX5, LMNA, PLCZ1, PPARA, PPARG
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 4 C5AR1, CD14, LIPE, PLA2G6
Multi-pass membrane protein 2 C5AR1, CACNA1I
cell surface 1 TF
Golgi apparatus 1 CD14
Golgi membrane 1 INS
Cytoplasm, cytosol 2 ALOX5, LIPE
plasma membrane 7 C5AR1, CACNA1I, CD14, F2, PLA2G6, REN, TF
Membrane 5 CACNA1I, CAT, LIPE, PLA2G6, REN
apical plasma membrane 1 TF
basolateral plasma membrane 1 C5AR1
caveola 1 LIPE
extracellular exosome 5 CAT, CD14, F2, LYZ, TF
extracellular space 10 ALOX5, CD14, F2, GNRH1, INS, LYZ, PLA2G6, REN, TF, XDH
perinuclear region of cytoplasm 5 ALOX5, LMNA, PLCZ1, PPARG, TF
mitochondrion 2 CAT, PLA2G6
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 2 CAT, PPARG
pronucleus 1 PLCZ1
Secreted 7 CD14, F2, INS, PLA2G12A, PLA2G2D, REN, TF
extracellular region 11 ALOX5, CAT, CD14, F2, GNRH1, INS, LYZ, PLA2G12A, PLA2G2D, REN, TF
basal part of cell 1 TF
mitochondrial matrix 1 CAT
Nucleus membrane 1 ALOX5
nuclear membrane 2 ALOX5, LMNA
external side of plasma membrane 1 CD14
cytoplasmic vesicle 2 C5AR1, TF
microtubule cytoskeleton 1 PLA2G6
nucleolus 1 PLCZ1
Early endosome 1 TF
apical part of cell 2 C5AR1, REN
clathrin-coated pit 1 TF
recycling endosome 1 TF
vesicle 1 TF
Cytoplasm, perinuclear region 2 ALOX5, PLCZ1
Membrane raft 1 CD14
focal adhesion 1 CAT
Peroxisome 2 CAT, XDH
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 F2
intermediate filament 1 LMNA
nuclear speck 2 LMNA, PLA2G6
Late endosome 1 TF
receptor complex 1 PPARG
chromatin 2 PPARA, PPARG
blood microparticle 2 F2, TF
Lipid-anchor, GPI-anchor 1 CD14
site of double-strand break 1 LMNA
nuclear envelope 2 ALOX5, LMNA
Nucleus envelope 2 ALOX5, LMNA
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Nucleus, nucleoplasm 1 LMNA
side of membrane 1 CD14
pseudopodium 1 PLA2G6
basal plasma membrane 1 TF
lipopolysaccharide receptor complex 1 CD14
ficolin-1-rich granule lumen 2 ALOX5, CAT
secretory granule lumen 4 ALOX5, CAT, INS, TF
HFE-transferrin receptor complex 1 TF
secretory granule membrane 2 C5AR1, CD14
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 3 F2, INS, TF
nuclear matrix 2 ALOX5, LMNA
voltage-gated calcium channel complex 1 CACNA1I
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
endocytic vesicle 1 TF
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Nucleus matrix 2 ALOX5, LMNA
nuclear envelope lumen 1 ALOX5
nuclear lamina 1 LMNA
clathrin-coated endocytic vesicle membrane 1 TF
Cell projection, pseudopodium 1 PLA2G6
vesicle coat 1 TF
Nucleus lamina 1 LMNA
[Isoform C]: Nucleus speckle 1 LMNA
lamin filament 1 LMNA
catalase complex 1 CAT
sperm head 1 PLCZ1
Nucleus intermembrane space 1 ALOX5
dense body 1 TF


文献列表

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  • Qian Sun, Jiawen Yang, Ming Zhang, Yongsheng Zhang, Hongyu Ma, Ngoc Tuan Tran, Xiuli Chen, Yueling Zhang, Kok-Gan Chan, Shengkang Li. Exosomes drive ferroptosis by stimulating iron accumulation to inhibit bacterial infection in crustaceans. The Journal of biological chemistry. 2023 Dec; 299(12):105463. doi: 10.1016/j.jbc.2023.105463. [PMID: 37977221]
  • Shun-Hong Luo, Jia-Ming Tian, Yi Chu, Hong-Yi Zhu, Jiang-Dong Ni, Jun Huang. The BRD4-SRPK2-SRSF2 signal modulates the splicing efficiency of ACSL3 pre-mRNA and influences erastin-induced ferroptosis in osteosarcoma cells. Cell death & disease. 2023 11; 14(11):760. doi: 10.1038/s41419-023-06273-2. [PMID: 37993451]
  • Paulina Oyarzún, Jonathan Carrasco, Darlene Peterssen, Gonzalo Tereucan, Mario Aranda, Karem Henríquez-Aedo. A high throughput method for detection of cyclooxygenase-2 enzyme inhibitors by effect-directed analysis applying high performance thin layer chromatography-bioassay-mass spectrometry. Journal of chromatography. A. 2023 Nov; 1711(?):464426. doi: 10.1016/j.chroma.2023.464426. [PMID: 37862751]
  • Leandro Gastón Parra, Luciana Cecilia Erjavec, Cecilia Irene Casali, Andrea Zerpa Velazquez, Karen Weber, Clara Patricia Setton-Avruj, María Del Carmen Fernández Tome. Cytosolic phospholipase A2 regulates lipid homeostasis under osmotic stress through PPARγ. The FEBS journal. 2023 Nov; ?(?):. doi: 10.1111/febs.16998. [PMID: 37947039]
  • Wei Chen, Jinhao Su, Yubin Liu, Tianmei Gao, Xiaohui Ji, Hanzhou Li, Huajun Li, Yuansong Wang, Hui Zhang, Shuquan Lv. Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPARγ, and TGF-β/Smad Pathways in Mice. Current drug metabolism. 2023 Nov; ?(?):. doi: 10.2174/0113892002257928231031113337. [PMID: 37936469]
  • Mirielle L Pauline, Caitlin Huynh, Pamela R Wizzard, Patrick N Nation, Catherine J Field, Paul W Wales, Justine M Turner. In parenteral nutrition-fed piglets, fatty acids vary by lipid emulsion and tissue sampled. JPEN. Journal of parenteral and enteral nutrition. 2023 11; 47(8):1038-1046. doi: 10.1002/jpen.2547. [PMID: 37416983]
  • Dmitry V Chistyakov, Nadezhda V Azbukina, Alexander V Lopachev, Sergei V Goriainov, Alina A Astakhova, Elena V Ptitsyna, Anna S Klimenko, Vsevolod V Poleshuk, Rogneda B Kazanskaya, Tatiana N Fedorova, Marina G Sergeeva. Plasma oxylipin profiles reflect Parkinson's disease stage. Prostaglandins & other lipid mediators. 2023 Oct; ?(?):106788. doi: 10.1016/j.prostaglandins.2023.106788. [PMID: 37866654]
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