Usnic_acid (BioDeep_00000017243)

Main id: BioDeep_00000007878

 

human metabolite PANOMIX_OTCML-2023 blood metabolite Antitumor activity


代谢物信息卡片


4,10-diacetyl-11,13-dihydroxy-2,12-dimethyl-8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(9),6,10,12-tetraene-3,5-dione

化学式: C18H16O7 (344.0896)
中文名称: 松萝酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(=C2C(=C1O)C3(C(=CC(=O)C(C3=O)C(=O)C)O2)C)C(=O)C)O
InChI: InChI=1S/C18H16O7/c1-6-14(22)12(8(3)20)16-13(15(6)23)18(4)10(25-16)5-9(21)11(7(2)19)17(18)24/h5,11,22-23H,1-4H3

描述信息

7-Hydroxy-(S)-usnate is a member of benzofurans.
Usnic acid is a natural product found in Lecanora muralis, Usnea florida, and other organisms with data available.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
Usnic acid, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid has excellent anticancer and antimicrobial properties. Usnic acid significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1[1].
Usnic acid, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid has excellent anticancer and antimicrobial properties. Usnic acid significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1[1].

同义名列表

46 个代谢物同义名

4,10-diacetyl-11,13-dihydroxy-2,12-dimethyl-8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(9),6,10,12-tetraene-3,5-dione; 4,10-diacetyl-11,13-dihydroxy-2,12-dimethyl-8-oxatricyclo[7.4.0.0,2,7]trideca-1(13),6,9,11-tetraene-3,5-dione; 2,6-Diacetyl-1,2,3,9b-tetrahydro-7,9-dihydroxy-8,9b-dimethyldiben- zofuran-1,3-dione/ Usno; 2,6-Diacetyl-1,2,3,9b-tetrahydro-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione; 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-9bh-dibenzofuran-1,3-dione, AldrichCPR; (+/-)-1,3(2H,9bH)-Dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-; 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzo[b,d]furan-1,3(2H,9bh)-dione #; 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzo[b,d]furan-1,3(2H,9bh)-dione; 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-dibenzofuran-1,3-dione;Usnic acid; 1,3(2H,9bH)-Dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-; 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bH)-dibenzofurandione; Dibenzofuran-1,9bH)-dione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-; 1,9bH)-Dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-; 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-dibenzofuran-1,3-dione; 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione; Usnic acid, Antibiotic for Culture Media Use Only; CUCUKLJLRRAKFN-UHFFFAOYSA-N; Usninsaeure [German]; 7-Hydroxy-(S)-usnate; (.+/-.)-Usnic acid; Spectrum2_000744; Spectrum5_000541; Spectrum4_001811; Spectrum3_001195; (+-)-Uanic acid; UNII-0W584PFJ77; USNIC ACID, (L); USNIC ACID, (D); (±)-Usnic acid; DivK1c_001009; KBio3_002369; L-Usnic acid; KBio2_005793; KBio2_003225; NCI60_004436; KBio2_000657; KBio1_001009; NCI60_004437; Usinic acid; IDI1_001009; Uanic acid; Usnic acid; usnic-acid; AI3-50457; Usnic; Usno



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

34 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ANG, ANXA5, BCL2, CASP3, CASP7, CCND1, MSMP, MTOR, NOS2, TDP1, TYR, VEGFA
Peripheral membrane protein 3 ANXA5, CYP1B1, MTOR
Endoplasmic reticulum membrane 3 BCL2, CYP1B1, MTOR
Nucleus 12 ANG, BCL2, CASP3, CASP7, CCND1, GABPA, LIG4, MTOR, NOS2, PARP1, TDP1, VEGFA
cytosol 10 ANG, ANXA5, BCL2, CASP3, CASP7, CCND1, GSR, MTOR, NOS2, PARP1
dendrite 1 MTOR
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
centrosome 1 CCND1
nucleoplasm 10 CASP3, CASP7, CCND1, GABPA, LIG4, MTOR, NOS2, PARP1, TDP1, TOP1MT
Cytoplasmic side 1 MTOR
Golgi apparatus membrane 1 MTOR
cell surface 1 VEGFA
glutamatergic synapse 1 CASP3
Golgi apparatus 1 VEGFA
Golgi membrane 1 MTOR
growth cone 1 ANG
lysosomal membrane 2 GAA, MTOR
neuronal cell body 2 ANG, CASP3
sarcolemma 1 ANXA5
Cytoplasm, cytosol 3 CASP7, NOS2, PARP1
Lysosome 3 GAA, MTOR, TYR
plasma membrane 3 GAA, NOS2, TDP1
Membrane 7 ANXA5, BCL2, CYP1B1, GAA, MTOR, PARP1, VEGFA
extracellular exosome 3 ANXA5, GAA, GSR
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 2 BCL2, VEGFA
extracellular space 4 ANG, CASP7, MSMP, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 NOS2, TYR
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
mitochondrion 5 BCL2, CYP1B1, GSR, PARP1, TOP1MT
protein-containing complex 2 BCL2, PARP1
intracellular membrane-bounded organelle 5 CYP1B1, GAA, LIG4, TDP1, TYR
Microsome membrane 2 CYP1B1, MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TYR
Secreted 4 ANG, GAA, MSMP, VEGFA
extracellular region 4 ANG, ANXA5, GAA, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
mitochondrial matrix 1 GSR
transcription regulator complex 1 PARP1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 2 ANXA5, GSR
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
nucleolus 2 ANG, PARP1
Melanosome membrane 1 TYR
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Golgi-associated vesicle 1 TYR
Cytoplasm, perinuclear region 1 NOS2
pore complex 1 BCL2
focal adhesion 1 ANXA5
extracellular matrix 1 VEGFA
mitochondrial nucleoid 1 TOP1MT
Peroxisome 1 NOS2
basement membrane 1 ANG
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
Zymogen granule membrane 1 ANXA5
chromatin 2 GABPA, PARP1
Chromosome 3 ANG, PARP1, TOP1MT
Secreted, extracellular space 1 CASP7
Nucleus, nucleolus 2 ANG, PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 2 LIG4, PARP1
site of double-strand break 1 PARP1
nuclear envelope 2 MTOR, PARP1
Endomembrane system 1 MTOR
tertiary granule membrane 1 GAA
Melanosome 1 TYR
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
myelin sheath 1 BCL2
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
azurophil granule membrane 1 GAA
vesicle membrane 1 ANXA5
protein-DNA complex 1 PARP1
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
condensed chromosome 1 LIG4
Cytoplasmic vesicle, phagosome 1 MTOR
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
cortical cytoskeleton 1 NOS2
angiogenin-PRI complex 1 ANG
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
DNA-dependent protein kinase-DNA ligase 4 complex 1 LIG4
nonhomologous end joining complex 1 LIG4
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin D1-CDK6 complex 1 CCND1
DNA ligase IV complex 1 LIG4


文献列表

  • Theerthu Azhamuthu, Suresh Kathiresan, Ilanchitchenni Senkuttuvan, Nihal Ahamed Abulkalam Asath, Pugazhendhi Ravichandran. Usnic acid attenuates 7,12-dimethylbenz[a] anthracene (DMBA) induced oral carcinogenesis through inhibiting oxidative stress, inflammation, and cell proliferation in male golden Syrian hamster model. Journal of biochemical and molecular toxicology. 2023 Oct; ?(?):e23553. doi: 10.1002/jbt.23553. [PMID: 37840363]
  • Magdalena Kulinowska, Sławomir Dresler, Agnieszka Skalska-Kamińska, Agnieszka Hanaka, Maciej Strzemski. Methodological Aspects of Green Extraction of Usnic Acid Using Natural Deep Eutectic Solvents. Molecules (Basel, Switzerland). 2023 Jul; 28(14):. doi: 10.3390/molecules28145321. [PMID: 37513195]
  • Han Zhang, Xiaojie Li, Xue Liu, Xia Ji, Xuan Ma, Jun Chen, Yanmin Bao, Yingdan Zhang, Liangxiong Xu, Liang Yang, Xiaoyi Wei. The usnic acid derivative peziculone targets cell wall of Gram-positive bacteria revealed by high throughput CRISPRi-seq analysis. International journal of antimicrobial agents. 2023 Jun; ?(?):106876. doi: 10.1016/j.ijantimicag.2023.106876. [PMID: 37276892]
  • Maulidiyah Maulidiyah, Faradillah Rachman, La Ode Muhammad Zuhdi Mulkiyan, Muhammad Natsir, Nohong Nohong, Akhmad Darmawan, La Ode Agus Salim, Muhammad Nurdin. Antioxidant Activity of Usnic Acid Compound from Methanol Extract of Lichen Usnea sp. Journal of oleo science. 2023 Feb; 72(2):179-188. doi: 10.5650/jos.ess22315. [PMID: 36631103]
  • Serpil Kiliç Yayla, Zekiye Kocakaya, Gökçe Şeker Karatoprak, Selen İlgün, Ahmet Ceylan. Analyzing the Impact of Ramalina digitellata, R. fastigiata, R. fraxinea, and R. polymorpha's Usnic Acid Concentration on Antioxidant, DNA-Protective, Antimicrobial, and Cytotoxic Properties. Chemistry & biodiversity. 2023 Jan; 20(1):e202200816. doi: 10.1002/cbdv.202200816. [PMID: 36482033]
  • Tatyana I Rokitskaya, Alexander M Arutyunyan, Ljudmila S Khailova, Alisa D Kataeva, Alexander M Firsov, Elena A Kotova, Yuri N Antonenko. Usnic Acid-Mediated Exchange of Protons for Divalent Metal Cations across Lipid Membranes: Relevance to Mitochondrial Uncoupling. International journal of molecular sciences. 2022 Dec; 23(24):. doi: 10.3390/ijms232416203. [PMID: 36555847]
  • Hanxue Wang, Min Xuan, Cheng Huang, Changhong Wang. Advances in Research on Bioactivity, Toxicity, Metabolism, and Pharmacokinetics of Usnic Acid In Vitro and In Vivo. Molecules (Basel, Switzerland). 2022 Nov; 27(21):. doi: 10.3390/molecules27217469. [PMID: 36364296]
  • Madhuree Kumari, Siya Kamat, C Jayabaskaran. Usnic acid induced changes in biomolecules and their association with apoptosis in squamous carcinoma (A-431) cells: A flow cytometry, FTIR and DLS spectroscopic study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Jun; 274(?):121098. doi: 10.1016/j.saa.2022.121098. [PMID: 35257985]
  • Agnieszka Pyrczak-Felczykowska, Tristan A Reekie, Marcin Jąkalski, Aleksandra Hać, Marcelina Malinowska, Anna Pawlik, Kamil Ryś, Beata Guzow-Krzemińska, Anna Herman-Antosiewicz. The Isoxazole Derivative of Usnic Acid Induces an ER Stress Response in Breast Cancer Cells That Leads to Paraptosis-like Cell Death. International journal of molecular sciences. 2022 Feb; 23(3):. doi: 10.3390/ijms23031802. [PMID: 35163724]
  • Tatyana I Rokitskaya, Elena A Kotova, Yuri N Antonenko. Anomalous potentials on bilayer lipid membranes in the presence of usnic acid: Markin-Sokolov versus Nernst-Donnan equilibrium. Bioelectrochemistry (Amsterdam, Netherlands). 2021 Oct; 141(?):107825. doi: 10.1016/j.bioelechem.2021.107825. [PMID: 34030021]
  • Małgorzata Kikowska, Barbara Thiem, Karolina Jafernik, Marta Klimek-Szczykutowicz, Elżbieta Studzińska-Sroka, Halina Ekiert, Agnieszka Szopa. Effect of Elicitation with (+)-Usnic Acid on Accumulation of Phenolic Acids and Flavonoids in Agitated Microshoots of Eryngium alpinum L. Molecules (Basel, Switzerland). 2021 Sep; 26(18):. doi: 10.3390/molecules26185532. [PMID: 34577004]
  • Sreeja Lakshmi, Shamprasad Varija Raghu, Preetham Elumalai, Sureshkumar Sivan. Alkoxy glycerol enhanced activity of Oxyresveratrol in Alzheimer's disease by rescuing Tau protein. Neuroscience letters. 2021 08; 759(?):135981. doi: 10.1016/j.neulet.2021.135981. [PMID: 34023407]
  • Sukfan P Kwong, Zhenlin Huang, Lili Ji, Changhong Wang. PORIMIN: The key to (+)-Usnic acid-induced liver toxicity and oncotic cell death in normal human L02 liver cells. Journal of ethnopharmacology. 2021 Apr; 270(?):113873. doi: 10.1016/j.jep.2021.113873. [PMID: 33485970]
  • Cristina Avonto, Amar G Chittiboyina, Shabana I Khan, Olivia R Dale, Jon F Parcher, Mei Wang, Ikhlas A Khan. Are atranols the only skin sensitizers in oakmoss? A systematic investigation using non-animal methods. Toxicology in vitro : an international journal published in association with BIBRA. 2021 Feb; 70(?):105053. doi: 10.1016/j.tiv.2020.105053. [PMID: 33212168]
  • Camila Andre Cazarin, Ana Paula Dalmagro, Ana Elisa Gonçalves, Thaise Boeing, Luísa Mota da Silva, Rogério Corrêa, Luiz Carlos Klein-Júnior, Bernardo Carlesso Pinto, Thaís Savoldi Lorenzett, Thales Uchôa da Costa Sobrinho, Ângelo de Fátima, Tiago Coelho de Assis Lage, Sergio Antonio Fernandes, Márcia Maria de Souza. Usnic acid enantiomers restore cognitive deficits and neurochemical alterations induced by Aβ1-42 in mice. Behavioural brain research. 2021 01; 397(?):112945. doi: 10.1016/j.bbr.2020.112945. [PMID: 33022354]
  • Péligris Henrique Dos Santos, Thassio Mesquita, Rodrigo Miguel-Dos-Santos, Grace Kelly Melo de Almeida, Lucas Andrade de Sá, Paula Dos Passos Menezes, Adriano Antunes de Souza Araujo, Sandra Lauton-Santos. Inclusion complex with β-cyclodextrin is a key determining factor for the cardioprotection induced by usnic acid. Chemico-biological interactions. 2020 Dec; 332(?):109297. doi: 10.1016/j.cbi.2020.109297. [PMID: 33096055]
  • Sukfan P Kwong, Changhong Wang. Review: Usnic acid-induced hepatotoxicity and cell death. Environmental toxicology and pharmacology. 2020 Nov; 80(?):103493. doi: 10.1016/j.etap.2020.103493. [PMID: 32961280]
  • Sukfan P Kwong, Hanxue Wang, Liang Shi, Zhenlin Huang, Bin Lu, Xuemei Cheng, Guixin Chou, Lili Ji, Changhong Wang. Identification of photodegraded derivatives of usnic acid with improved toxicity profile and UVA/UVB protection in normal human L02 hepatocytes and epidermal melanocytes. Journal of photochemistry and photobiology. B, Biology. 2020 Apr; 205(?):111814. doi: 10.1016/j.jphotobiol.2020.111814. [PMID: 32092663]
  • Kunal Kumar, Jai P N Mishra, Rana P Singh. Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and γ-H2A.X phosphorylation. Chemico-biological interactions. 2020 Jan; 315(?):108898. doi: 10.1016/j.cbi.2019.108898. [PMID: 31715134]
  • Richard Staples, Robert L LaDuca, Ludmila V Roze, Maris Laivenieks, John E Linz, Randolph Beaudry, Alan Fryday, Anthony L Schilmiller, Anna V Koptina, Benjamin Smith, Frances Trail. Structure and Chemical Analysis of Major Specialized Metabolites Produced by the Lichen Evernia prunastri. Chemistry & biodiversity. 2020 Jan; 17(1):e1900465. doi: 10.1002/cbdv.201900465. [PMID: 31701649]
  • Agnieszka Pyrczak-Felczykowska, Rajeshwar Narlawar, Anna Pawlik, Beata Guzow-Krzemińska, Damian Artymiuk, Aleksandra Hać, Kamil Ryś, Louis M Rendina, Tristan A Reekie, Anna Herman-Antosiewicz, Michael Kassiou. Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer Cells. Journal of natural products. 2019 07; 82(7):1768-1778. doi: 10.1021/acs.jnatprod.8b00980. [PMID: 31282672]
  • Hallysson Douglas A Araújo, José G Silva Júnior, João R Saturnino Oliveira, Maria Helena M L Ribeiro, Mônica C Barroso Martins, Marcos A Cavalcanti Bezerra, André Lima Aires, Mônica C P Azevedo Albuquerque, Mário R Melo-Júnior, Nicodemos T Pontes Filho, Eugênia C Pereira, Diego J Raposo Silva, Janaína V Dos Anjos, Emerson Peter S Falcão, Nicácio H Silva, Vera L Menezes Lima. Usnic Acid Potassium Salt: Evaluation of the Acute Toxicity and Antinociceptive Effect in Murine Model. Molecules (Basel, Switzerland). 2019 May; 24(11):. doi: 10.3390/molecules24112042. [PMID: 31142045]
  • Yuri N Antonenko, Ljudmila S Khailova, Tatyana I Rokitskaya, Ekaterina S Nosikova, Pavel A Nazarov, Ol'ga A Luzina, Nariman F Salakhutdinov, Elena A Kotova. Mechanism of action of an old antibiotic revisited: Role of calcium ions in protonophoric activity of usnic acid. Biochimica et biophysica acta. Bioenergetics. 2019 04; 1860(4):310-316. doi: 10.1016/j.bbabio.2019.01.005. [PMID: 30710552]
  • Ludan Hou, Yiran Jin, Wenjing Sun, Shuai Guan, Huijun Xu, Qiao Wang, Lantong Zhang, Yingfeng Du. Metabolites identification of (+)-usnic acid in vivo by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Fitoterapia. 2019 Mar; 133(?):85-95. doi: 10.1016/j.fitote.2018.12.020. [PMID: 30605779]
  • Ilya Prokopiev, Galina Filippova, Eduard Filippov, Ivan Voronov, Igor Sleptsov, Aliy Zhanataev. Genotoxicity of (+)- and (-)-usnic acid in mice. Mutation research. Genetic toxicology and environmental mutagenesis. 2019 Mar; 839(?):36-39. doi: 10.1016/j.mrgentox.2019.01.010. [PMID: 30744810]
  • Ashish Garg, Sweta Garg, Nitendra K Sahu, Sarita Rani, Umesh Gupta, Awesh K Yadav. Heparin appended ADH-anionic polysaccharide nanoparticles for site-specific delivery of usnic acid. International journal of pharmaceutics. 2019 Feb; 557(?):238-253. doi: 10.1016/j.ijpharm.2018.12.049. [PMID: 30594688]
  • Djalma M de Oliveira, Cristiane B Pereira, Graziele Mendes, Jochen Junker, Markus Kolloff, Luiz H Rosa, Carlos A Rosa, Tânia M A Alves, Carlos L Zani, Susana Johann, Betania B Cota. Two new usnic acid derivatives from the endophytic fungus Mycosphaerella sp. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2018 Nov; 73(11-12):449-455. doi: 10.1515/znc-2017-0162. [PMID: 30179857]
  • Yi Yang, Woo Kyun Bae, Ji-Yoon Lee, Yong Jae Choi, Kyung Hwa Lee, Myong-Suk Park, Young Hyun Yu, So-Yeon Park, Rui Zhou, İsa Taş, Chathurika Gamage, Man-Jeong Paik, Jae Hyuk Lee, Ik Joo Chung, Kyung Keun Kim, Jae-Seoun Hur, Sang Kyum Kim, Hyung-Ho Ha, Hangun Kim. Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer. Scientific reports. 2018 11; 8(1):16234. doi: 10.1038/s41598-018-34709-9. [PMID: 30390003]
  • Yazhi Gao, Wei Liu, Xiaoxiong Wang, Lihua Yang, Su Han, Shiguo Chen, Reto Jörg Strasser, Bernal E Valverde, Sheng Qiang. Comparative phytotoxicity of usnic acid, salicylic acid, cinnamic acid and benzoic acid on photosynthetic apparatus of Chlamydomonas reinhardtii. Plant physiology and biochemistry : PPB. 2018 Jul; 128(?):1-12. doi: 10.1016/j.plaphy.2018.04.037. [PMID: 29751250]
  • Changhai Qu, Lingling Zhang, Xueying Du, Xiaoyan Zhang, Jiao Zheng, Yunfang Zhao, Pengfei Tu. Preparation and evaluation of wet-milled usnic acid nanocrystal suspension for better bioaffinity. Drug development and industrial pharmacy. 2018 May; 44(5):707-712. doi: 10.1080/03639045.2017.1409756. [PMID: 29183154]
  • Hanxue Wang, Tao Yang, Xuemei Cheng, Sukfan Kwong, Chenghai Liu, Rui An, Guowen Li, Xinhong Wang, Changhong Wang. Simultaneous determination of usnic, diffractaic, evernic and barbatic acids in rat plasma by ultra-high-performance liquid chromatography-quadrupole exactive Orbitrap mass spectrometry and its application to pharmacokinetic studies. Biomedical chromatography : BMC. 2018 Mar; 32(3):. doi: 10.1002/bmc.4123. [PMID: 29055065]
  • Vadim Yu Kryukov, Oksana G Tomilova, Olga A Luzina, Olga N Yaroslavtseva, Yuriy B Akhanaev, Maksim V Tyurin, Bahytzhan A Duisembekov, Nariman F Salakhutdinov, Viktor V Glupov. Effects of fluorine-containing usnic acid and fungus Beauveria bassiana on the survival and immune-physiological reactions of Colorado potato beetle larvae. Pest management science. 2018 Mar; 74(3):598-606. doi: 10.1002/ps.4741. [PMID: 28945317]
  • Yi Wang, Changan Geng, Xiaolong Yuan, Mei Hua, Fenghua Tian, Changtian Li. Identification of a putative polyketide synthase gene involved in usnic acid biosynthesis in the lichen Nephromopsis pallescens. PloS one. 2018; 13(7):e0199110. doi: 10.1371/journal.pone.0199110. [PMID: 30020937]
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