(-)-Parthenolide (BioDeep_00000171481)
human metabolite blood metabolite
代谢物信息卡片
4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.0^{2,4}]tetradec-7-en-13-one
化学式: C15H20O3 (248.14123700000002)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 2.68%
分子结构信息
SMILES: CC1=CCCC2(C)OC2C2OC(=O)C(=C)C2CC1
InChI: InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
19 个相关的物种来源信息
- 3412 Magnolia virginiana:
- 86757 Magnolia champaca:
- 215555 Magnolia laevifolia:
- 86772 Magnolia lanuginosa:
- 81865 Magnolia praecocissima:
- 54732 Magnolia kobus:
- 1204776 Cyathocline purpurea: 10.1016/0031-9422(81)84063-0
- 152188 Magnolia ovata: 10.1021/NP900203Y
- 127999 Tanacetum parthenium:
- 3412 Magnolia virginiana:
- 86757 Magnolia champaca:
- 215555 Magnolia laevifolia:
- 86772 Magnolia lanuginosa:
- 81865 Magnolia praecocissima:
- 54732 Magnolia kobus:
- 1204776 Cyathocline purpurea: 10.1016/0031-9422(81)84063-0
- 152188 Magnolia ovata: 10.1021/NP900203Y
- 127999 Tanacetum parthenium:
- 9606 Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lei Li, Qian Zhou, Linwei Li, Tingting Ran, Weiwu Wang, Chenyang Liu, Jin Chen, Tiemin Sun, Yu Chen, Xu Feng, Feng Zhang, Shu Xu. Structural insight into subunit F of respiratory chain complex I from Xanthomonas oryzae pv. oryzae inhibition by parthenolide.
Pest management science.
2024 Jun; 80(6):2679-2688. doi:
10.1002/ps.7974. [PMID: 38284296] - Zi-Ying Zhan, Zhi-Hong Zhang, Rong-Hui Sun, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. A therapeutic strategy of parthenolide in improving imiquimod-induced psoriasis-like skin inflammation targeting IL-36/NETs through skin transdermal therapeutic system.
International immunopharmacology.
2024 Apr; 131(?):111824. doi:
10.1016/j.intimp.2024.111824. [PMID: 38461633] - Jinfeng Sun, Liwei Li, Li Xiong, Fan Chen, Lingyu She, Hao Tang, Yuqing Zeng, Ying Duan, Luyao Li, Wei Wang, Gao Li, Xia Zhao, Guang Liang. Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 169(?):115909. doi:
10.1016/j.biopha.2023.115909. [PMID: 37992573] - Liru Huang, Fuhong Liu, Xukai Liu, Liyan Niu, Longhua Sun, Fang Fang, Kun Ma, Ping Hu. Parthenolide inhibits the proliferation and migration of cervical cancer cells via FAK/GSK3β pathway.
Cancer chemotherapy and pharmacology.
2023 Dec; ?(?):. doi:
10.1007/s00280-023-04621-9. [PMID: 38141074] - Emine Toraman, Büşra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacımüftüoğlu. Role of parthenolide in paclitaxel-induced oxidative stress injury and impaired reproductive function in rat testicular tissue.
Chemico-biological interactions.
2023 Nov; ?(?):110793. doi:
10.1016/j.cbi.2023.110793. [PMID: 37949423] - W Yao, X Wang, Y Yang, J You, J Jin, P Zeng, Q Han, X Yao, X Sun, J Zhou. [Liposome nanoparticles for targeted delivery of parthenolide induce colorectal cancer necroptosis to ameliorate tumor-infiltrating T cell exhaustion in mice].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2023 Oct; 43(10):1674-1681. doi:
10.12122/j.issn.1673-4254.2023.10.04. [PMID: 37933642] - María Ángeles Ávila-Gálvez, Daniela Marques, Inês Figueira, Katarina Cankar, Dirk Bosch, Maria Alexandra Brito, Cláudia Nunes Dos Santos. Costunolide and parthenolide: Novel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightness.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Sep; 167(?):115413. doi:
10.1016/j.biopha.2023.115413. [PMID: 37683593] - Jingyuan Sun, Pei Li, Honglian Gui, Laure Rittié, David B Lombard, Katrin Rietscher, Thomas M Magin, Qing Xie, Li Liu, M Bishr Omary. Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation.
JCI insight.
2023 07; 8(14):. doi:
10.1172/jci.insight.166314. [PMID: 37485877] - Le-Tian Huang, Tie-Jun Li, Ming-Lin Li, Han-Yong Luo, Yi-Bing Wang, Jia-He Wang. Untargeted lipidomic analysis and network pharmacology for parthenolide treated papillary thyroid carcinoma cells.
BMC complementary medicine and therapies.
2023 Apr; 23(1):130. doi:
10.1186/s12906-023-03944-7. [PMID: 37095470] - Mehmet Enes Arslan, Hasan Türkez, Yasemin Sevim, Harun Selvitopi, Abdurrahim Kadi, Sena Öner, Adil Mardinoğlu. Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson's Disease Model.
Cells.
2023 03; 12(7):. doi:
10.3390/cells12070992. [PMID: 37048065] - Meng Li, Qiong Luo, Xi Chen, Furong Qiu, Yanyan Tao, Xin Sun, Chenghai Liu. Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns.
BMC complementary medicine and therapies.
2023 Jan; 23(1):9. doi:
10.1186/s12906-023-03836-w. [PMID: 36627617] - Reza Shahhoseini, Hadiseh Daneshvar. Phytochemical and physiological reactions of feverfew (Tanacetum parthenium (L.) Schultz Bip) to TiO2 nanoparticles.
Plant physiology and biochemistry : PPB.
2023 Jan; 194(?):674-684. doi:
10.1016/j.plaphy.2022.12.011. [PMID: 36563573] - Arman Beyraghdar Kashkooli, Aalt D J van Dijk, Harro Bouwmeester, Alexander van der Krol. Individual lipid transfer proteins from Tanacetum parthenium show different specificity for extracellular accumulation of sesquiterpenes.
Plant molecular biology.
2023 Jan; 111(1-2):153-166. doi:
10.1007/s11103-022-01316-2. [PMID: 36255594] - Li-Ping Liu, Ning Liu, Han-Ni Zhang, Ding Li. Exploring and validating the metastasis mechanism of pathenolide interfering with cutaneous melanoma through ER stress-dependent apoptosis based on the network pharmacology.
Phytochemical analysis : PCA.
2022 Dec; ?(?):. doi:
10.1002/pca.3193. [PMID: 36477977] - Mahsa Darbahani, Mahdi Rahaie, Asa Ebrahimi, Mahmood Khosrowshahli. The effects of several abiotic elicitors on the expression of genes of key enzymes involved in the parthenolide biosynthetic pathway and its content in feverfew plant (Tanacetum parthenium L.).
Natural product research.
2022 Dec; 36(23):6132-6136. doi:
10.1080/14786419.2022.2055555. [PMID: 35356827] - Xingchen Liu, Xiaobing Wang. Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents.
Chinese journal of natural medicines.
2022 Nov; 20(11):814-829. doi:
10.1016/s1875-5364(22)60238-3. [PMID: 36427916] - Qian Zhou, Linwei Li, Fei Liu, Jun Hu, Yan Cao, Siwei Qiao, Yuxin Zhou, Bi Wang, Yihe Jia, Yu Chen, Shu Xu, Xu Feng. Mining and characterization of oxidative stress-related binding proteins of parthenolide in Xanthomonas oryzae pv. oryzae.
Pest management science.
2022 Aug; 78(8):3345-3355. doi:
10.1002/ps.6961. [PMID: 35491536] - Yiting Shi, Tianyu Dong, Boxuan Zeng, Mingdong Yao, Ying Wang, Zexiong Xie, Wenhai Xiao, Yingjin Yuan. Production of Plant Sesquiterpene Lactone Parthenolide in the Yeast Cell Factory.
ACS synthetic biology.
2022 07; 11(7):2473-2483. doi:
10.1021/acssynbio.2c00132. [PMID: 35723427] - Anshuo Li, Wenbin Gao, Xuwu Zhang, Yuwei Deng, Yuhui Zhu, Hao Gu, Jin Wen, Xinquan Jiang. A dual-responsive 'Yin-Yang' photothermal delivery system to accelerate Parthenolide anti-tumor efficacy.
Biomaterials advances.
2022 Jul; 138(?):212935. doi:
10.1016/j.bioadv.2022.212935. [PMID: 35913256] - Ricardo A Leitão, Carlos A Fontes-Ribeiro, Ana Paula Silva. The effect of parthenolide on methamphetamine-induced blood-brain barrier and astrocyte alterations.
European journal of clinical investigation.
2022 Apr; 52(4):e13694. doi:
10.1111/eci.13694. [PMID: 34694635] - Tao An, Huanhuan Yin, Yanting Lu, Feng Liu. The Emerging Potential of Parthenolide Nanoformulations in Tumor Therapy.
Drug design, development and therapy.
2022; 16(?):1255-1272. doi:
10.2147/dddt.s355059. [PMID: 35517982] - Yubo Dong, Xuanjin Qian, Jian Li. Sesquiterpene Lactones and Cancer: New Insight into Antitumor and Anti-inflammatory Effects of Parthenolide-Derived Dimethylaminomicheliolide and Micheliolide.
Computational and mathematical methods in medicine.
2022; 2022(?):3744837. doi:
10.1155/2022/3744837. [PMID: 35898475] - Mingxian Lan, Xi Gao, Xiuan Duan, Hongmei Li, Hang Yu, Jinliang Li, Yueqin Zhao, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Guoxing Wu. Nematicidal activity of tirotundin and parthenolide isolated from Tithonia diversifolia and Chrysanthemum parthenium.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2022; 57(1):54-61. doi:
10.1080/03601234.2021.2022945. [PMID: 34983315] - Zhen-Yu Cui, Ge Wang, Jing Zhang, Jian Song, Yu-Chen Jiang, Jia-Yi Dou, Li-Hua Lian, Ji-Xing Nan, Yan-Ling Wu. Parthenolide, bioactive compound of Chrysanthemum parthenium L., ameliorates fibrogenesis and inflammation in hepatic fibrosis via regulating the crosstalk of TLR4 and STAT3 signaling pathway.
Phytotherapy research : PTR.
2021 Oct; 35(10):5680-5693. doi:
10.1002/ptr.7214. [PMID: 34250656] - Louna Karam, Soumaiah Abou Staiteieh, Rady Chaaban, Berthe Hayar, Bassel Ismail, Frank Neipel, Nadine Darwiche, Raghida Abou Merhi. Anticancer activities of parthenolide in primary effusion lymphoma preclinical models.
Molecular carcinogenesis.
2021 08; 60(8):567-581. doi:
10.1002/mc.23324. [PMID: 34101920] - Shaohua Zhang, Xiaoman Ju, Qihong Yang, Yiying Zhu, Dongmei Fan, Guifeng Su, Lingmei Kong, Yan Li. USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide.
Biochemical and biophysical research communications.
2021 07; 562(?):21-28. doi:
10.1016/j.bbrc.2021.05.017. [PMID: 34030041] - Weihong Wang, Yukai He, Qiuli Liu. Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease through the activation of the HIPPO pathway.
Molecular medicine reports.
2021 07; 24(1):. doi:
10.3892/mmr.2021.12126. [PMID: 33955510] - Jade Jaffar, Ian Glaspole, Karen Symons, Glen Westall. Inhibition of NF-κB by ACT001 reduces fibroblast activity in idiopathic pulmonary fibrosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jun; 138(?):111471. doi:
10.1016/j.biopha.2021.111471. [PMID: 33730605] - Perwez Alam, Nasir Ali Siddiqui, Md Tabish Rehman, Afzal Hussain, Ali Akhtar, Showkat R Mir, Mohamed Fahad Alajmi. Box-Behnken Design (BBD)-Based Optimization of Microwave-Assisted Extraction of Parthenolide from the Stems of Tarconanthus camphoratus and Cytotoxic Analysis.
Molecules (Basel, Switzerland).
2021 Mar; 26(7):. doi:
10.3390/molecules26071876. [PMID: 33810340] - Sawalee Saosathan, Jalernsri Khounvong, Methee Rungrojsakul, Trinnakorn Katekunlaphan, Singkome Tima, Sawitree Chiampanichayakul, Cory Berkland, Songyot Anuchapreeda. Costunolide and parthenolide from Champi Sirindhorn (Magnolia sirindhorniae) inhibit leukemic cell proliferation in K562 and molt-4 cell lines.
Natural product research.
2021 Mar; 35(6):988-992. doi:
10.1080/14786419.2019.1610752. [PMID: 31135208] - Dandan Liu, Yanyan Han, Lei Liu, Xinxiu Ren, Han Zhang, Shujun Fan, Tao Qin, Lianhong Li. Parthenolide inhibits the tumor characteristics of renal cell carcinoma.
International journal of oncology.
2021 01; 58(1):100-110. doi:
10.3892/ijo.2020.5148. [PMID: 33367934] - Minghua Liu, Ying Yang, Dajun Liu, Ye Cao, Yan Li. Parthenolide increases the sensitivity of gastric cancer cells to chemotherapy.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2020 12; 40(6):908-916. doi:
10.19852/j.cnki.jtcm.2020.06.002. [PMID: 33258341] - Seyede Zahra Ahmadi, Mansour Ghorbanpour, Ahmad Aghaee, Javad Hadian. Deciphering morpho-physiological and phytochemical attributes of Tanacetum parthenium L. plants exposed to C60 fullerene and salicylic acid.
Chemosphere.
2020 Nov; 259(?):127406. doi:
10.1016/j.chemosphere.2020.127406. [PMID: 32585459] - Evy Paulsen, Klaus E Andersen. Compositae sensitization in Danish children and adolescents.
Contact dermatitis.
2020 Oct; 83(4):296-300. doi:
10.1111/cod.13639. [PMID: 32542786] - Mohsen Bahrami, Mohammad Kamalinejad, Seied Amirhossein Latifi, Farhad Seif, Majid Dadmehr. Cytokine storm in COVID-19 and parthenolide: Preclinical evidence.
Phytotherapy research : PTR.
2020 Oct; 34(10):2429-2430. doi:
10.1002/ptr.6776. [PMID: 32472655] - Longhua Sun, Wenxin Yuan, Guilan Wen, Bentong Yu, Fei Xu, Xin Gan, Jianjun Tang, Qinghua Zeng, Lanlan Zhu, Chuanhui Chen, Wei Zhang. Parthenolide inhibits human lung cancer cell growth by modulating the IGF‑1R/PI3K/Akt signaling pathway.
Oncology reports.
2020 09; 44(3):1184-1193. doi:
10.3892/or.2020.7649. [PMID: 32705224] - Lili Yuan, Zhe Wang, Dongyang Zhang, Jiahe Wang. Metabonomic study of the intervention effects of Parthenolide on anti-thyroid cancer activity.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Aug; 1150(?):122179. doi:
10.1016/j.jchromb.2020.122179. [PMID: 32506011] - Jin-Ho Park, Young-Hoon Kang, Sun-Chul Hwang, Se Heang Oh, June-Ho Byun. Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-α via Inhibiting JNK Signaling.
International journal of molecular sciences.
2020 Jul; 21(15):. doi:
10.3390/ijms21155433. [PMID: 32751648] - Lichun Yu, Caihui Zhang, Yuan Chen, Qian Li, Jing Wang, Shuzhen Sun. Parthenolide ameliorates tweak-induced podocytes injury.
Molecular biology reports.
2020 Jul; 47(7):5165-5173. doi:
10.1007/s11033-020-05591-4. [PMID: 32572732] - Pan Liang, Hangyi Wu, Zhenhai Zhang, Shulong Jiang, Huixia Lv. Preparation and characterization of parthenolide nanocrystals for enhancing therapeutic effects of sorafenib against advanced hepatocellular carcinoma.
International journal of pharmaceutics.
2020 Jun; 583(?):119375. doi:
10.1016/j.ijpharm.2020.119375. [PMID: 32344021] - Jie Qiu, Chun-Mao Yuan, Min Wen, Ya-Nan Li, Juan Chen, Jun-You Jian, Lie-Jun Huang, Wei Gu, Yan-Mei Li, Xiao-Jiang Hao. Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry.
Journal of Asian natural products research.
2020 May; 22(5):425-433. doi:
10.1080/10286020.2019.1597055. [PMID: 31012734] - Robert R A Freund, Philipp Gobrecht, Dietmar Fischer, Hans-Dieter Arndt. Advances in chemistry and bioactivity of parthenolide.
Natural product reports.
2020 04; 37(4):541-565. doi:
10.1039/c9np00049f. [PMID: 31763637] - Wenbin Gao, Lei Li, Xuwu Zhang, Liyao Luo, Yuchu He, Cong Cong, Dawei Gao. Nanomagnetic liposome-encapsulated parthenolide and indocyanine green for targeting and chemo-photothermal antitumor therapy.
Nanomedicine (London, England).
2020 04; 15(9):871-890. doi:
10.2217/nnm-2019-0038. [PMID: 32223505] - Qiu Fa Hao, Bao Bao Wang, Wei Zhang, Wei Qiu, Qian Ling Liu, Xue Mei Li. NF-κB Inhibitor Parthenolide Promotes Renal Tubules Albumin Uptake in Type 2 Diabetic Nephropathy.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih.
2020 Mar; 35(1):31-42. doi:
10.24920/003573. [PMID: 32299536] - Xue Li, Lingmei Kong, Qihong Yang, Aizhu Duan, Xiaoman Ju, Bicheng Cai, Lin Chen, Tao An, Yan Li. Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth.
The Journal of biological chemistry.
2020 03; 295(11):3576-3589. doi:
10.1074/jbc.ra119.011396. [PMID: 32029476] - Qianqian Liu, Shaozhi Zhang, Dashuai Zhu, Xinyu Tang, Yongzhe Che, Xizeng Feng. The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice.
Behavioural brain research.
2020 02; 379(?):112337. doi:
10.1016/j.bbr.2019.112337. [PMID: 31697983] - Xin Jin, Qing Yang, Ning Cai, Zhenhai Zhang. A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.
Nanomedicine (London, England).
2020 01; 15(1):41-54. doi:
10.2217/nnm-2018-0479. [PMID: 31868113] - Joanna Nawrot, Marta Napierała, Kinga Kaczerowska-Pietrzak, Ewa Florek, Justyna Gornowicz-Porowska, Ewa Pelant, Gerard Nowak. The Anti-Serotonin Effect of Parthenolide Derivatives and Standardised Extract from the Leaves of Stizolophus balsamita.
Molecules (Basel, Switzerland).
2019 Nov; 24(22):. doi:
10.3390/molecules24224131. [PMID: 31731603] - Evy Paulsen, Klaus E Andersen. Screening for Compositae contact sensitization with sesquiterpene lactones and Compositae mix 2.5\% pet.
Contact dermatitis.
2019 Nov; 81(5):368-373. doi:
10.1111/cod.13346. [PMID: 31265134] - Wei-Feng Gao, Yi-Xuan Li, Wei-Hua Zhang, Ran Tao, Ting-Ting Yin, Yi-Jia Wang, Li-Na Liu, Zhi-Wei Fu, Sai-Nan Li, Nai-Rong Liu, Heng Zhang, Guang Liu, Li-Zhong Zhao, Xi-Peng Zhang, Chun-Ze Zhang. Comparison of the inhibition potential of parthenolide and micheliolide on various UDP-glucuronosyltransferase isoforms.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Oct; 49(10):1158-1163. doi:
10.1080/00498254.2018.1544383. [PMID: 30484368] - Charles A Berdan, Raymond Ho, Haley S Lehtola, Milton To, Xirui Hu, Tucker R Huffman, Yana Petri, Chad R Altobelli, Sasha G Demeulenaere, James A Olzmann, Thomas J Maimone, Daniel K Nomura. Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells.
Cell chemical biology.
2019 07; 26(7):1027-1035.e22. doi:
10.1016/j.chembiol.2019.03.016. [PMID: 31080076] - Chae Young Kim, Bobin Kang, Hyung Joo Suh, Hyeon-Son Choi. Parthenolide, a feverfew-derived phytochemical, ameliorates obesity and obesity-induced inflammatory responses via the Nrf2/Keap1 pathway.
Pharmacological research.
2019 07; 145(?):104259. doi:
10.1016/j.phrs.2019.104259. [PMID: 31078744] - Arman Beyraghdar Kashkooli, Alexander R van der Krol, Patrick Rabe, Jeroen S Dickschat, Harro Bouwmeester. Substrate promiscuity of enzymes from the sesquiterpene biosynthetic pathways from Artemisia annua and Tanacetum parthenium allows for novel combinatorial sesquiterpene production.
Metabolic engineering.
2019 07; 54(?):12-23. doi:
10.1016/j.ymben.2019.01.007. [PMID: 30822491] - Eti Mehrotra, Jyotsna Vishwakarma, Avinash C Tripathi, Pankaj K Sonar, Shailendra K Saraf. Schizonticidal antimalarial sesquiterpene lactones from Magnolia champaca (L.) Baill. ex Pierre: microwave-assisted extraction, HPTLC fingerprinting and computational studies.
Natural product research.
2019 Feb; 33(4):568-572. doi:
10.1080/14786419.2017.1396595. [PMID: 29086620] - Qianling Liu, Liangyan Zhang, Wei Zhang, Qiufa Hao, Wei Qiu, Yubing Wen, Haiyun Wang, Xuemei Li. Inhibition of NF-κB Reduces Renal Inflammation and Expression of PEPCK in Type 2 Diabetic Mice.
Inflammation.
2018 Dec; 41(6):2018-2029. doi:
10.1007/s10753-018-0845-0. [PMID: 30066289] - Shu Xu, Xingzeng Zhao, Fei Liu, Yan Cao, Bi Wang, Xiangyun Wang, Min Yin, Qizhi Wang, Xu Feng. Crucial role of oxidative stress in bactericidal effect of parthenolide against Xanthomonas oryzae pv. oryzae.
Pest management science.
2018 Dec; 74(12):2716-2723. doi:
10.1002/ps.5091. [PMID: 29808556] - Qing Liu, Arman Beyraghdar Kashkooli, David Manzano, Irini Pateraki, Lea Richard, Pim Kolkman, Maria Fátima Lucas, Victor Guallar, Ric C H de Vos, Maurice C R Franssen, Alexander van der Krol, Harro Bouwmeester. Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity.
Nature communications.
2018 11; 9(1):4657. doi:
10.1038/s41467-018-06565-8. [PMID: 30405138] - Evy Paulsen, Rime B El-Houri, Klaus E Andersen, Lars P Christensen. Parthenolide in Danish biodynamic and organic milk: A new source of exposure to an allergenic sesquiterpene lactone.
Contact dermatitis.
2018 Oct; 79(4):208-212. doi:
10.1111/cod.13043. [PMID: 29923204] - Weihuan Mao, Ziguan Zhu. Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis.
Molecular medicine reports.
2018 Jun; 17(6):8369-8376. doi:
10.3892/mmr.2018.8908. [PMID: 29693172] - Manmohit Kalia, Vivek Kumar Yadav, Pradeep Kumar Singh, Deepmala Sharma, Shahid Suhail Narvi, Vishnu Agarwal. Exploring the impact of parthenolide as anti-quorum sensing and anti-biofilm agent against Pseudomonas aeruginosa.
Life sciences.
2018 Apr; 199(?):96-103. doi:
10.1016/j.lfs.2018.03.013. [PMID: 29524516] - Xiaoliang Zhu, Chunmao Yuan, Chenyang Tian, Chen Li, Fen Nie, Xiaomin Song, Rong Zeng, Dianqing Wu, Xiaojiang Hao, Lin Li. The plant sesquiterpene lactone parthenolide inhibits Wnt/β-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1.
The Journal of biological chemistry.
2018 04; 293(14):5335-5344. doi:
10.1074/jbc.m117.819300. [PMID: 29462785] - Hanan Alwaseem, Benjamin J Frisch, Rudi Fasan. Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
Bioorganic & medicinal chemistry.
2018 04; 26(7):1365-1373. doi:
10.1016/j.bmc.2017.08.009. [PMID: 28826596] - Nagarethinam Baskaran, Govindan Sadasivam Selvam, Subramani Yuvaraj, Albert Abhishek. Parthenolide attenuates 7,12-dimethylbenz[a]anthracene induced hamster buccal pouch carcinogenesis.
Molecular and cellular biochemistry.
2018 Mar; 440(1-2):11-22. doi:
10.1007/s11010-017-3151-5. [PMID: 28801714] - Nesa Jafari, Sonbol Nazeri, Sattar Tahmasebi Enferadi. Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factor α - 1 expression.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Mar; 41(?):67-73. doi:
10.1016/j.phymed.2018.01.022. [PMID: 29519321] - Shuguang Yuan, Xuemei Liu, Xuejing Zhu, Zhong Qu, Zailiang Gong, Jun Li, Li Xiao, Yuan Yang, Hong Liu, Lin Sun, Fuyou Liu. The Role of TLR4 on PGC-1α-Mediated Oxidative Stress in Tubular Cell in Diabetic Kidney Disease.
Oxidative medicine and cellular longevity.
2018; 2018(?):6296802. doi:
10.1155/2018/6296802. [PMID: 29861832] - Érica Benassi-Zanqueta, Caroline Fernandes Marques, Samara Requena Nocchi, Benedito Prado Dias Filho, Celso Vataru Nakamura, Tania Ueda-Nakamura. Parthenolide Influences Herpes simplex virus 1 Replication in vitro.
Intervirology.
2018; 61(1):14-22. doi:
10.1159/000490055. [PMID: 30001535] - Xuemei Li, Huike Yang, Jia Ke, Baoquan Liu, Xiaohong Lv, Xinlei Li, Yafang Zhang. Smad4 re-expression increases the sensitivity to parthenolide in colorectal cancer.
Oncology reports.
2017 Oct; 38(4):2317-2324. doi:
10.3892/or.2017.5929. [PMID: 28902368] - Tao Li, Whayoung Lee, Hidetaka Hara, Cassandra Long, Mohamed Ezzelarab, David Ayares, Hai Huang, Yi Wang, Charles T Esmon, David K C Cooper, Hayato Iwase. An Investigation of Extracellular Histones in Pig-To-Baboon Organ Xenotransplantation.
Transplantation.
2017 10; 101(10):2330-2339. doi:
10.1097/tp.0000000000001676. [PMID: 28157735] - Lara Soares Aleixo de Carvalho, Lívia Beatriz Almeida Fontes, Matheus Coutinho Gazolla, Débora Dos Santos Dias, Maria Aparecida Juliano, Gilson Costa Macedo, José Otávio do Amaral Corrêa, Ademar A Da Silva Filho. Parthenolide Modulates Immune Response in Cells from C57BL/6 Mice Induced with Experimental Autoimmune Encephalomyelitis.
Planta medica.
2017 May; 83(8):693-700. doi:
10.1055/s-0042-122783. [PMID: 27997959] - Minting Lin, Hong Bi, Yanyan Yan, Wenjing Huang, Guiping Zhang, Genshui Zhang, Sili Tang, Yun Liu, Lingling Zhang, Jinxiang Ma, Jianye Zhang. Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth via B-Raf/MAPK/Erk pathway.
Oncotarget.
2017 Apr; 8(14):23436-23447. doi:
10.18632/oncotarget.15584. [PMID: 28423582] - Z Arıkan-Ayyıldız, M Karaman, S Özbal, A Bağrıyanık, O Yilmaz, Ö Karaman, N Uzuner. Efficacy of parthenolide on lung histopathology in a murine model of asthma.
Allergologia et immunopathologia.
2017 Jan; 45(1):63-68. doi:
10.1016/j.aller.2016.06.005. [PMID: 27717727] - Soudeh Farzadfar, Fatemeh Zarinkamar, Mehrdad Behmanesh, Mostafa Hojati. Magnesium and manganese interactively modulate parthenolide accumulation and the antioxidant defense system in the leaves of Tanacetum parthenium.
Journal of plant physiology.
2016 Sep; 202(?):10-20. doi:
10.1016/j.jplph.2016.06.017. [PMID: 27450490] - Dongzhu Duan, Junmin Zhang, Juan Yao, Yaping Liu, Jianguo Fang. Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells.
The Journal of biological chemistry.
2016 May; 291(19):10021-31. doi:
10.1074/jbc.m115.700591. [PMID: 27002142] - Ai-qin Zhao, Ji-hong Zhao, Shu-qing Zhang, Yong-yang Pan, Xu-lei Huo. Determination of parthenolide in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2016 Feb; 119(?):99-103. doi:
10.1016/j.jpba.2015.11.039. [PMID: 26678176] - Mohammad Majdi, Morahem Ashengroph, Mohammad Reza Abdollahi. Sesquiterpene lactone engineering in microbial and plant platforms: parthenolide and artemisinin as case studies.
Applied microbiology and biotechnology.
2016 Feb; 100(3):1041-1059. doi:
10.1007/s00253-015-7128-6. [PMID: 26567019] - Tien-Yao Tsai, Shyh-Liang Lou, Ka-Shun Cheng, Kar-Lok Wong, Mei-Ling Wang, Tzu-Hui Su, Paul Chan, Yuk-Man Leung. Repressed Ca(2+) clearance in parthenolide-treated murine brain bEND.3 endothelial cells.
European journal of pharmacology.
2015 Dec; 769(?):280-6. doi:
10.1016/j.ejphar.2015.11.031. [PMID: 26607466] - Mohammad Majdi, Mohammad Reza Abdollahi, Asad Maroufi. Parthenolide accumulation and expression of genes related to parthenolide biosynthesis affected by exogenous application of methyl jasmonate and salicylic acid in Tanacetum parthenium.
Plant cell reports.
2015 Nov; 34(11):1909-18. doi:
10.1007/s00299-015-1837-2. [PMID: 26183953] - Muhamad S F Zawawi, Victor Marino, Egon Perilli, Melissa D Cantley, Jiake Xu, P Edward Purdue, Anak A S S K Dharmapatni, David R Haynes, Tania N Crotti. Parthenolide reduces empty lacunae and osteoclastic bone surface resorption induced by polyethylene particles in a murine calvarial model of peri-implant osteolysis.
Journal of biomedical materials research. Part A.
2015 Nov; 103(11):3572-9. doi:
10.1002/jbm.a.35484. [PMID: 25903444] - Zhong-Jin Yang, Wei-Zhi Ge, Qiu-Ying Li, Yaxin Lu, Jian-Miao Gong, Bei-Jia Kuang, Xiaonan Xi, Haiting Wu, Quan Zhang, Yue Chen. Syntheses and Biological Evaluation of Costunolide, Parthenolide, and Their Fluorinated Analogues.
Journal of medicinal chemistry.
2015 Sep; 58(17):7007-20. doi:
10.1021/acs.jmedchem.5b00915. [PMID: 26226279] - Dipankar De, Geeti Khullar, Sanjeev Handa. Performance of a commercially available plant allergen series in the assessment of suspected occupational contact dermatitis to plants in north Indian patients.
Indian journal of dermatology, venereology and leprology.
2015 Jul; 81(4):376-9. doi:
10.4103/0378-6323.156199. [PMID: 25937142] - Joseph K Hexum, Chani M Becker, Aaron M Kempema, John R Ohlfest, David A Largaespada, Daniel A Harki. Parthenolide prodrug LC-1 slows growth of intracranial glioma.
Bioorganic & medicinal chemistry letters.
2015 Jun; 25(12):2493-5. doi:
10.1016/j.bmcl.2015.04.058. [PMID: 25978958] - Fan-Cong Kong, Jing-Qiong Zhang, Chen Zeng, Wen-Lan Chen, Wen-Xiang Ren, Guo-Xin Yan, Hong-Xiang Wang, Qiu-Bai Li, Zhi-Chao Chen. Inhibitory effects of parthenolide on the activity of NF-κB in multiple myeloma via targeting TRAF6.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
2015 Jun; 35(3):343-349. doi:
10.1007/s11596-015-1435-0. [PMID: 26072071] - Michael Plöger, Jandirk Sendker, Klaus Langer, Thomas J Schmidt. Covalent modification of human serum albumin by the natural sesquiterpene lactone parthenolide.
Molecules (Basel, Switzerland).
2015 Apr; 20(4):6211-23. doi:
10.3390/molecules20046211. [PMID: 25859779] - Natalie Schneider, Holger Ludwig, Peter Nick. Suppression of tubulin detyrosination by parthenolide recruits the plant-specific kinesin KCH to cortical microtubules.
Journal of experimental botany.
2015 Apr; 66(7):2001-11. doi:
10.1093/jxb/erv012. [PMID: 25779700] - Yan Zhao, Jiancheng Wang, Hongyu Li, Qianqian Jia, Sijia Chen, Zhaozhong Xu, Xiaoyan Du, Xiaowen Chen, Lu Lu, Bo Huang, Haibo Long. [Shenkang pill down-regulates AOPP-induced expression of inflammatory factor MCP-1 via a p38MAPK/NF-κB-dependent mechanism].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2014 Aug; 34(9):1265-71. doi:
NULL. [PMID: 25263356] - Tatiana Shioji Tiuman, Tânia Ueda-Nakamura, Antonio Alonso, Celso Vataru Nakamura. Cell death in amastigote forms of Leishmania amazonensis induced by parthenolide.
BMC microbiology.
2014 Jun; 14(?):152. doi:
10.1186/1471-2180-14-152. [PMID: 24913205] - Vikram K Mahajan, Vikas Sharma, Mrinal Gupta, Pushpinder S Chauhan, Karaninder S Mehta, Swati Garg. Parthenium dermatitis: is parthenolide an effective choice for patch testing?.
Contact dermatitis.
2014 Jun; 70(6):340-3. doi:
10.1111/cod.12194. [PMID: 24617958] - Katarzyna Gach, Anna Janecka. α-Methylene-γ-lactones as a novel class of anti-leukemic agents.
Anti-cancer agents in medicinal chemistry.
2014 Jun; 14(5):688-94. doi:
10.2174/1871520614666140313095010. [PMID: 24628266] - Qing Liu, David Manzano, Nikola Tanić, Milica Pesic, Jasna Bankovic, Irini Pateraki, Lea Ricard, Albert Ferrer, Ric de Vos, Sander van de Krol, Harro Bouwmeester. Elucidation and in planta reconstitution of the parthenolide biosynthetic pathway.
Metabolic engineering.
2014 May; 23(?):145-53. doi:
10.1016/j.ymben.2014.03.005. [PMID: 24704560] - Nicoletta Galeotti, Anna Maidecchi, Luisa Mattoli, Michela Burico, Carla Ghelardini. St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes.
Fitoterapia.
2014 Jan; 92(?):23-33. doi:
10.1016/j.fitote.2013.10.003. [PMID: 24125916] - Taichi Mitsui, Risa Ishihara, Ken-ichiro Hayashi, Mitsuhisa Sunadome, Nobuyasu Matsuura, Hiroshi Nozaki. New cassane-type diterpenoids of Caesalpinia echinata (Leguminosae) exhibiting NF-κB inhibitory activities.
Chemical & pharmaceutical bulletin.
2014; 62(3):267-73. doi:
10.1248/cpb.c13-00812. [PMID: 24583781] - Anna Wyrębska, Katarzyna Gach, Anna Janecka. Combined effect of parthenolide and various anti-cancer drugs or anticancer candidate substances on malignant cells in vitro and in vivo.
Mini reviews in medicinal chemistry.
2014; 14(3):222-8. doi:
10.2174/1389557514666140219113509. [PMID: 24552263] - Serena Materazzi, Silvia Benemei, Camilla Fusi, Roberta Gualdani, Gaetano De Siena, Nisha Vastani, David A Andersson, Gabriela Trevisan, Maria Rosa Moncelli, Xiaomei Wei, Gregory Dussor, Federica Pollastro, Riccardo Patacchini, Giovanni Appendino, Pierangelo Geppetti, Romina Nassini. Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.
Pain.
2013 Dec; 154(12):2750-2758. doi:
10.1016/j.pain.2013.08.002. [PMID: 23933184] - Fang-Xiao Zhu, Run-Hua Zhou, Yu-Hong Shi, Yang Qin. [Effect of parthenolide on serum expressions of interleukin-1beta and tumor necrosis factor-alpha in rabbits with knee osteoarthritis].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2013 Oct; 33(10):1382-4. doi:
NULL. [PMID: 24432684] - Akram Ghantous, Ansam Sinjab, Zdenko Herceg, Nadine Darwiche. Parthenolide: from plant shoots to cancer roots.
Drug discovery today.
2013 Sep; 18(17-18):894-905. doi:
10.1016/j.drudis.2013.05.005. [PMID: 23688583] - Quanjun Yang, Lili Wan, Zhiyong Zhou, Yan Li, Qi Yu, Liya Liu, Bin Li, Cheng Guo. Parthenolide from Parthenium integrifolium reduces tumor burden and alleviate cachexia symptoms in the murine CT-26 model of colorectal carcinoma.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Aug; 20(11):992-8. doi:
10.1016/j.phymed.2013.04.020. [PMID: 23746953] - M Helena R Amorim, Rui M Gil da Costa, Carlos Lopes, Margarida M S M Bastos. Sesquiterpene lactones: adverse health effects and toxicity mechanisms.
Critical reviews in toxicology.
2013 Aug; 43(7):559-79. doi:
10.3109/10408444.2013.813905. [PMID: 23875764] - Yu Zhao, Jia Su, Masuo Goto, Susan L Morris-Natschke, Yan Li, Qin-Shi Zhao, Zhu-Jun Yao, Kuo-Hsiung Lee. Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation.
Journal of medicinal chemistry.
2013 Jun; 56(11):4749-57. doi:
10.1021/jm400479p. [PMID: 23725535] - Manuela Polimeni, Elena Valente, Elisabetta Aldieri, Amina Khadjavi, Giuliana Giribaldi, Mauro Prato. Role of 15-hydroxyeicosatetraenoic acid in hemozoin-induced lysozyme release from human adherent monocytes.
BioFactors (Oxford, England).
2013 May; 39(3):304-14. doi:
10.1002/biof.1071. [PMID: 23355332]