Valinomycin (BioDeep_00000001695)
natural product Chemicals and Drugs Antitumor activity Cytotoxicity
代谢物信息卡片
(3S,6S,9R,12R,15S,18S,21R,24R,27S,30S,33R,36R)-6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone
化学式: C54H90N6O18 (1110.6311)
中文名称: 缬氨霉素
谱图信息:
最多检出来源 () 0%
Reviewed
Last reviewed on 2024-10-09.
Cite this Page
Valinomycin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/valinomycin (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000001695). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CC(C)[C@@H]1NC(=O)C(C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
InChI: InChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D049990 - Membrane Transport Modulators
D007476 - Ionophores
A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
Valinomycin is a potassium-specific ionophore, the valinomycin-K+ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K+ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research[1][2].
Valinomycin (NSC 122023), a cyclic depsipeptide antibiotic, act as a potassium selective ionophore. Valinomycin (NSC 122023) inhibits lymphocyte proliferation by its effects on the cell membrane, and induces apoptosis in CHO cells[1]. Valinomycin induces activation of PINK1 leading to Parkin Ser65 phosphorylation[2].
同义名列表
7 个代谢物同义名
valinomycin; Valinomicin; CID 14147354; 3,6,9,15,18,21,27,30,33-Nonaisopropyl-12,24,36-trimethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaaza-cyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecaone; cyclo[OAla-Val-D-OVal-D-Val-OAla-Val-D-OVal-D-Val-OAla-Val-D-OVal-DL-Val]; NSC 122023; Valinomycin
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:95123
- ChEBI: CHEBI:28545
- KEGG: C06684
- PubChem: 5649
- PubChem: 3000706
- PubChem: 14147354
- PubChem: 441139
- Metlin: METLIN64667
- DrugBank: DB14057
- ChEMBL: CHEMBL602575
- ChEMBL: CHEMBL223643
- ChEMBL: CHEMBL4777382
- MeSH: Valinomycin
- CAS: 2001-95-8
- MoNA: CCMSLIB00000006901
- MoNA: CCMSLIB00000006902
- MoNA: CCMSLIB00000006903
- MoNA: CCMSLIB00000531483
- PMhub: MS000000997
- MetaboLights: MTBLC28545
- NIKKAJI: J9.541I
- medchemexpress: HY-N6693
- PubChem: 8909
- KNApSAcK: 28545
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
10 个相关的物种来源信息
- 76853 - Solibacillus silvestris: 10.1021/NP800603U
- 1892 - Streptomyces anulatus:
- 544311 - Streptomyces araujoniae:
- 66883 - Streptomyces cyaneofuscatus:
- 1905 - Streptomyces exfoliatus:
- 1911 - Streptomyces griseus:
- 1914 - Streptomyces lavendulae:
- 67317 - Streptomyces levoris:
- 1919 - Streptomyces microflavus:
- 285482 - Streptomyces tsusimaensis:
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- ZhangFei Su, J Jay Leitch, Slawomir Sek, Jacek Lipkowski. Ion-Pairing Mechanism for the Valinomycin-Mediated Transport of Potassium Ions across Phospholipid Bilayers.
Langmuir : the ACS journal of surfaces and colloids.
2021 08; 37(31):9613-9621. doi:
10.1021/acs.langmuir.1c01500. [PMID: 34323494] - Armelle T Mbaveng, Brice E N Wamba, Gabin T M Bitchagno, Simplice Beaudelaire Tankeo, İlhami Çelik, Brice C K Atontsa, Antoine H Nkuété Lonfouo, Victor Kuete, Thomas Efferth. Bioactivity of fractions and constituents of Piper capense fruits towards a broad panel of cancer cells.
Journal of ethnopharmacology.
2021 May; 271(?):113884. doi:
10.1016/j.jep.2021.113884. [PMID: 33529639] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Eduart Gutiérrez-Pineda, Patrizia Andreozzi, Eleftheria Diamanti, Ramiro Anguiano, Ronald F Ziolo, Sergio E Moya, María José Rodríguez-Presa, Claudio A Gervasi. Effects of valinomycin doping on the electrical and structural properties of planar lipid bilayers supported on polyelectrolyte multilayers.
Bioelectrochemistry (Amsterdam, Netherlands).
2021 Apr; 138(?):107688. doi:
10.1016/j.bioelechem.2020.107688. [PMID: 33227594] - Namrta Choudhry, Xin Zhao, Dan Xu, Mark Zanin, Weisan Chen, Zifeng Yang, Jianxin Chen. Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Journal of medicinal chemistry.
2020 11; 63(22):13205-13227. doi:
10.1021/acs.jmedchem.0c00626. [PMID: 32845145] - Dong Zhang, Zhi Ma, Hanchi Chen, Yuele Lu, Xiaolong Chen. Valinomycin as a potential antiviral agent against coronaviruses: A review.
Biomedical journal.
2020 10; 43(5):414-423. doi:
10.1016/j.bj.2020.08.006. [PMID: 33012699] - Jiří Czernek, Jiří Brus. Polymorphic Forms of Valinomycin Investigated by NMR Crystallography.
International journal of molecular sciences.
2020 Jul; 21(14):. doi:
10.3390/ijms21144907. [PMID: 32664570] - Renjie Wang, Xinfeng Du, Xueqing Ma, Jingying Zhai, Xiaojiang Xie. Ionophore-based pH independent detection of ions utilizing aggregation-induced effects.
The Analyst.
2020 Jun; 145(11):3846-3850. doi:
10.1039/d0an00486c. [PMID: 32293619] - Dong Zhang, Yuele Lu, Hanchi Chen, Chutian Wu, Hui Zhang, Luyi Chen, Xiaolong Chen. Antifungal peptides produced by actinomycetes and their biological activities against plant diseases.
The Journal of antibiotics.
2020 05; 73(5):265-282. doi:
10.1038/s41429-020-0287-4. [PMID: 32123311] - ZhangFei Su, XueQin Ran, J Jay Leitch, Adrian L Schwan, Robert Faragher, Jacek Lipkowski. How Valinomycin Ionophores Enter and Transport K+ across Model Lipid Bilayer Membranes.
Langmuir : the ACS journal of surfaces and colloids.
2019 12; 35(51):16935-16943. doi:
10.1021/acs.langmuir.9b03064. [PMID: 31742409] - Chunying Li, Hui Chen, Li Zhou, Hui Shi, Xiaoxiao He, Xiaohai Yang, Kemin Wang, Jianbo Liu. Single-stranded DNA designed lipophilic G-quadruplexes as transmembrane channels for switchable potassium transport.
Chemical communications (Cambridge, England).
2019 Oct; 55(80):12004-12007. doi:
10.1039/c9cc04176a. [PMID: 31503273] - Chang-Wook Jeon, Da-Ran Kim, Youn-Sig Kwak. Valinomycin, produced by Streptomyces sp. S8, a key antifungal metabolite in large patch disease suppressiveness.
World journal of microbiology & biotechnology.
2019 Aug; 35(8):128. doi:
10.1007/s11274-019-2704-z. [PMID: 31375920] - Renjie Wang, Xinfeng Du, Yaotian Wu, Jingying Zhai, Xiaojiang Xie. Graphene Quantum Dots Integrated in Ionophore-Based Fluorescent Nanosensors for Na+ and K.
ACS sensors.
2018 11; 3(11):2408-2414. doi:
10.1021/acssensors.8b00918. [PMID: 30387340] - Gal Masrati, Manish Dwivedi, Abraham Rimon, Yael Gluck-Margolin, Amit Kessel, Haim Ashkenazy, Itay Mayrose, Etana Padan, Nir Ben-Tal. Broad phylogenetic analysis of cation/proton antiporters reveals transport determinants.
Nature communications.
2018 10; 9(1):4205. doi:
10.1038/s41467-018-06770-5. [PMID: 30310075] - Simona D'Agostino, Chiara Della Monica, Eleonora Palizzi, Fabio Di Pietrantonio, Massimiliano Benetti, Domenico Cannatà, Marta Cavagnaro, Dariush Sardari, Pasquale Stano, Alfonsina Ramundo-Orlando. Extremely High Frequency Electromagnetic Fields Facilitate Electrical Signal Propagation by Increasing Transmembrane Potassium Efflux in an Artificial Axon Model.
Scientific reports.
2018 06; 8(1):9299. doi:
10.1038/s41598-018-27630-8. [PMID: 29915373] - Emiri Hotta, Hirokazu Hara, Tetsuro Kamiya, Tetsuo Adachi. Non-thermal atmospheric pressure plasma-induced IL-8 expression is regulated via intracellular K+ loss and subsequent ERK activation in human keratinocyte HaCaT cells.
Archives of biochemistry and biophysics.
2018 04; 644(?):64-71. doi:
10.1016/j.abb.2018.03.005. [PMID: 29518371] - A Makarasen, N Reukngam, P Khlaychan, P Chuysinuan, M Isobe, S Techasakul. Mode of action and synergistic effect of valinomycin and cereulide with amphotericin B against Candida albicans and Cryptococcus albidus.
Journal de mycologie medicale.
2018 Mar; 28(1):112-121. doi:
10.1016/j.mycmed.2017.11.007. [PMID: 29276078] - Ryuji Kawano. Synthetic Ion Channels and DNA Logic Gates as Components of Molecular Robots.
Chemphyschem : a European journal of chemical physics and physical chemistry.
2018 02; 19(4):359-366. doi:
10.1002/cphc.201700982. [PMID: 29124837] - Víctor G Almendro-Vedia, Paolo Natale, Michael Mell, Stephanie Bonneau, Francisco Monroy, Frederic Joubert, Iván López-Montero. Nonequilibrium fluctuations of lipid membranes by the rotating motor protein F1F0-ATP synthase.
Proceedings of the National Academy of Sciences of the United States of America.
2017 10; 114(43):11291-11296. doi:
10.1073/pnas.1701207114. [PMID: 29073046] - Rana A Ahmad, Lars Dietzel. Relaxation of cellular K+ gradients by valinomycin induces diatoxanthin accumulation in Cyclotella meneghiniana cells and alters FCPa fluorescence yield in vitro.
Physiologia plantarum.
2017 Sep; 161(1):171-180. doi:
10.1111/ppl.12599. [PMID: 28664565] - Richa Sharma, Vijaylakshmi Jamwal, Varun P Singh, Priya Wazir, Praveen Awasthi, Deepika Singh, Ram A Vishwakarma, Sumit G Gandhi, Asha Chaubey. Revelation and cloning of valinomycin synthetase genes in Streptomyces lavendulae ACR-DA1 and their expression analysis under different fermentation and elicitation conditions.
Journal of biotechnology.
2017 Jul; 253(?):40-47. doi:
10.1016/j.jbiotec.2017.05.008. [PMID: 28528783] - Haichong K Zhang, Ping Yan, Jeeun Kang, Diane S Abou, Hanh N D Le, Abhinav K Jha, Daniel L J Thorek, Jin U Kang, Arman Rahmim, Dean F Wong, Emad M Boctor, Leslie M Loew. Listening to membrane potential: photoacoustic voltage-sensitive dye recording.
Journal of biomedical optics.
2017 04; 22(4):45006. doi:
10.1117/1.jbo.22.4.045006. [PMID: 28394000] - Sean Maher, Hajra Basit, Robert J Forster, Tia E Keyes. Micron dimensioned cavity array supported lipid bilayers for the electrochemical investigation of ionophore activity.
Bioelectrochemistry (Amsterdam, Netherlands).
2016 Dec; 112(?):16-23. doi:
10.1016/j.bioelechem.2016.07.002. [PMID: 27420132] - Tatyana I Rokitskaya, Ljudmila S Khailova, Anton V Makarenkov, Valentina A Ol'shevskaya, Valery N Kalinin, Yuri N Antonenko. Weak C-H acids as protonophores can carry hydrogen ions through lipid membranes and mitochondria: a case of o-carborane.
Physical chemistry chemical physics : PCCP.
2016 Jun; 18(24):16476-82. doi:
10.1039/c6cp02581a. [PMID: 27265316] - Thomas B H Schroeder, Geoffray Leriche, Takaoki Koyanagi, Mitchell A Johnson, Kathryn N Haengel, Olivia M Eggenberger, Claire L Wang, Young Hun Kim, Karthik Diraviyam, David Sept, Jerry Yang, Michael Mayer. Effects of Lipid Tethering in Extremophile-Inspired Membranes on H(+)/OH(-) Flux at Room Temperature.
Biophysical journal.
2016 06; 110(11):2430-2440. doi:
10.1016/j.bpj.2016.04.044. [PMID: 27276261] - Salome Veshaguri, Sune M Christensen, Gerdi C Kemmer, Garima Ghale, Mads P Møller, Christina Lohr, Andreas L Christensen, Bo H Justesen, Ida L Jørgensen, Jürgen Schiller, Nikos S Hatzakis, Michael Grabe, Thomas Günther Pomorski, Dimitrios Stamou. Direct observation of proton pumping by a eukaryotic P-type ATPase.
Science (New York, N.Y.).
2016 Mar; 351(6280):1469-73. doi:
10.1126/science.aad6429. [PMID: 27013734] - Dong Wan Lee, Bee Gek Ng, Beom Seok Kim. Increased valinomycin production in mutants of Streptomyces sp. M10 defective in bafilomycin biosynthesis and branched-chain α-keto acid dehydrogenase complex expression.
Journal of industrial microbiology & biotechnology.
2015 Nov; 42(11):1507-17. doi:
10.1007/s10295-015-1679-5. [PMID: 26335568] - Yuri N Antonenko, Tatyana I Rokitskaya, Adam Huczyński. Electrogenic and nonelectrogenic ion fluxes across lipid and mitochondrial membranes mediated by monensin and monensin ethyl ester.
Biochimica et biophysica acta.
2015 Apr; 1848(4):995-1004. doi:
10.1016/j.bbamem.2015.01.005. [PMID: 25600660] - Charles G Cranfield, Taren Bettler, Bruce Cornell. Nanoscale ion sequestration to determine the polarity selectivity of ion conductance in carriers and channels.
Langmuir : the ACS journal of surfaces and colloids.
2015; 31(1):292-8. doi:
10.1021/la504057z. [PMID: 25474616] - Hennie Valkenier, Anthony P Davis. Making a match for Valinomycin: steroidal scaffolds in the design of electroneutral, electrogenic anion carriers.
Accounts of chemical research.
2013 Dec; 46(12):2898-909. doi:
10.1021/ar4000345. [PMID: 23514113] - Uzochi Chimdinma Ndukwe Erlingsson, Francesco Iacobazzi, Aiping Liu, Orly Ardon, Marzia Pasquali, Nicola Longo. The effect of valinomycin in fibroblasts from patients with fatty acid oxidation disorders.
Biochemical and biophysical research communications.
2013 Aug; 437(4):637-41. doi:
10.1016/j.bbrc.2013.07.020. [PMID: 23867825] - Matthew G Baile, Kevin Whited, Steven M Claypool. Deacylation on the matrix side of the mitochondrial inner membrane regulates cardiolipin remodeling.
Molecular biology of the cell.
2013 Jun; 24(12):2008-20. doi:
10.1091/mbc.e13-03-0121. [PMID: 23637464] - Victor V Lemeshko. Electrical potentiation of the membrane permeabilization by new peptides with anticancer properties.
Biochimica et biophysica acta.
2013 Mar; 1828(3):1047-56. doi:
10.1016/j.bbamem.2012.12.012. [PMID: 23262194] - Christopher M Halsey, Derek A Benham, Renee D JiJi, Jason W Cooley. Influence of the lipid environment on valinomycin structure and cation complex formation.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2012 Oct; 96(?):200-6. doi:
10.1016/j.saa.2012.05.022. [PMID: 22683555] - Francesco Milano, Massimo Trotta, Márta Dorogi, Béla Fischer, Livia Giotta, Angela Agostiano, Péter Maróti, László Kálmán, László Nagy. Light induced transmembrane proton gradient in artificial lipid vesicles reconstituted with photosynthetic reaction centers.
Journal of bioenergetics and biomembranes.
2012 Jun; 44(3):373-84. doi:
10.1007/s10863-012-9435-2. [PMID: 22528392] - Aubrey E Kusi-Appiah, Nicholas Vafai, Paula J Cranfill, Michael W Davidson, Steven Lenhert. Lipid multilayer microarrays for in vitro liposomal drug delivery and screening.
Biomaterials.
2012 Jun; 33(16):4187-94. doi:
10.1016/j.biomaterials.2012.02.023. [PMID: 22391265] - Diana M Castañeda, Luis Miguel Pombo, Claudia Patricia Urueña, John Fredy Hernandez, Susana Fiorentino. A gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze displays cytotoxic activity and raises sensitivity to doxorubicin in a leukemia cell line.
BMC complementary and alternative medicine.
2012 Apr; 12(?):38. doi:
10.1186/1472-6882-12-38. [PMID: 22490328] - Naoki Soga, Kazuhiko Kinosita, Masasuke Yoshida, Toshiharu Suzuki. Kinetic equivalence of transmembrane pH and electrical potential differences in ATP synthesis.
The Journal of biological chemistry.
2012 Mar; 287(12):9633-9. doi:
10.1074/jbc.m111.335356. [PMID: 22253434] - Radovan Fiser, Jiri Masin, Ladislav Bumba, Eva Pospisilova, Catherine Fayolle, Marek Basler, Lenka Sadilkova, Irena Adkins, Jana Kamanova, Jan Cerny, Ivo Konopasek, Radim Osicka, Claude Leclerc, Peter Sebo. Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores.
PLoS pathogens.
2012; 8(4):e1002580. doi:
10.1371/journal.ppat.1002580. [PMID: 22496638] - Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. An overview of the evidence and mechanisms of herb-drug interactions.
Frontiers in pharmacology.
2012; 3(?):69. doi:
10.3389/fphar.2012.00069. [PMID: 22557968] - Daniel Hagenfeld, Beatrice Borkenhagen, Tobias Schulz, Hermann Schillers, Udo Schumacher, Peter Prehm. Hyaluronan export through plasma membranes depends on concurrent K+ efflux by K(ir) channels.
PloS one.
2012; 7(6):e39096. doi:
10.1371/journal.pone.0039096. [PMID: 22701748] - Jack Dwayne Thrasher, Michael R Gray, Kaye H Kilburn, Donald P Dennis, Archie Yu. A water-damaged home and health of occupants: a case study.
Journal of environmental and public health.
2012; 2012(?):312836. doi:
10.1155/2012/312836. [PMID: 22220187] - Spencer D Watts, Katherine L Suchland, Susan G Amara, Susan L Ingram. A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes.
PloS one.
2012; 7(4):e35373. doi:
10.1371/journal.pone.0035373. [PMID: 22506078] - Lihong Zhu, Kazuo Inaba. Lipid rafts function in Ca2+ signaling responsible for activation of sperm motility and chemotaxis in the ascidian Ciona intestinalis.
Molecular reproduction and development.
2011 Dec; 78(12):920-9. doi:
10.1002/mrd.21382. [PMID: 21887722] - Inma Castilla-Cortázar, María García-Fernández, Gloria Delgado, Juan E Puche, Inma Sierra, Rima Barhoum, Salvador González-Barón. Hepatoprotection and neuroprotection induced by low doses of IGF-II in aging rats.
Journal of translational medicine.
2011 Jul; 9(?):103. doi:
10.1186/1479-5876-9-103. [PMID: 21733157] - Toshinori Komatsu, Miki Hiasa, Takaaki Miyaji, Takuji Kanamoto, Takuya Matsumoto, Masato Otsuka, Yoshinori Moriyama, Hiroshi Omote. Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter.
The international journal of biochemistry & cell biology.
2011 Jun; 43(6):913-8. doi:
10.1016/j.biocel.2011.03.005. [PMID: 21419862] - G V Danylovich, Iu V Danylovich, V F Gorchev. [Comparative investigation by spectrofluorimetry and flow cytometry of plasma and inner mitochondrial membranes polarisation in smooth muscle cell using potential-sensitive probe DiOC6(3)].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2011 May; 83(3):99-105. doi:
NULL. [PMID: 21888060] - Nazzareno D'Avanzo, Krzysztof Hyrc, Decha Enkvetchakul, Douglas F Covey, Colin G Nichols. Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol.
PloS one.
2011 Apr; 6(4):e19393. doi:
10.1371/journal.pone.0019393. [PMID: 21559361] - Damon Poburko, Jaime Santo-Domingo, Nicolas Demaurex. Dynamic regulation of the mitochondrial proton gradient during cytosolic calcium elevations.
The Journal of biological chemistry.
2011 Apr; 286(13):11672-84. doi:
10.1074/jbc.m110.159962. [PMID: 21224385] - Pablo Martinez-Becerra, Oscar Briz, Marta R Romero, Rocio I R Macias, Maria J Perez, Carlos Sancho-Mateo, Maria P Lostao, Jose M Fernandez-Abalos, Jose J G Marin. Further characterization of the electrogenicity and pH sensitivity of the human organic anion-transporting polypeptides OATP1B1 and OATP1B3.
Molecular pharmacology.
2011 Mar; 79(3):596-607. doi:
10.1124/mol.110.069971. [PMID: 21173039] - Emily Peterson, Ted Ryser, Spencer Funk, Daniel Inouye, Mukesh Sharma, Huajun Qin, Timothy A Cross, David D Busath. Functional reconstitution of influenza A M2(22-62).
Biochimica et biophysica acta.
2011 Feb; 1808(2):516-21. doi:
10.1016/j.bbamem.2010.10.010. [PMID: 20969830] - Hui-Fen Wu, Suresh Kumar Kailasa, Chi-Hsien Lin. Single drop microextraction coupled with matrix-assisted laser desorption/ionization mass spectrometry for rapid and direct analysis of hydrophobic peptides from biological samples in high salt solution.
Rapid communications in mass spectrometry : RCM.
2011 Jan; 25(2):307-15. doi:
10.1002/rcm.4843. [PMID: 21192026] - Stephen J Moore, Matthew G Fisher, Masafumi Yano, Christine C Tong, Philip A Gale. A dual host approach to transmembrane transport of salts.
Chemical communications (Cambridge, England).
2011 Jan; 47(2):689-91. doi:
10.1039/c0cc04430j. [PMID: 21103515] - Carmela Fimognari, Monia Lenzi, Lorenzo Ferruzzi, Eleonora Turrini, Paolo Scartezzini, Ferruccio Poli, Roberto Gotti, Alessandra Guerrini, Giovanni Carulli, Virginia Ottaviano, Giorgio Cantelli-Forti, Patrizia Hrelia. Mitochondrial pathway mediates the antileukemic effects of Hemidesmus indicus, a promising botanical drug.
PloS one.
2011; 6(6):e21544. doi:
10.1371/journal.pone.0021544. [PMID: 21738701] - Katie D Hickey, Mary M Buhr. Lipid bilayer composition affects transmembrane protein orientation and function.
Journal of lipids.
2011; 2011(?):208457. doi:
10.1155/2011/208457. [PMID: 21490797] - Beata Kosmider, Elise M Messier, Hong Wei Chu, Robert J Mason. Human alveolar epithelial cell injury induced by cigarette smoke.
PloS one.
2011; 6(12):e26059. doi:
10.1371/journal.pone.0026059. [PMID: 22163265] - Jiangping Bai, Douglas J Swartz, Irina I Protasevich, Christie G Brouillette, Patina M Harrell, Ellen Hildebrandt, Brigitte Gasser, Diethard Mattanovich, Andrew Ward, Geoffrey Chang, Ina L Urbatsch. A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris.
PloS one.
2011; 6(8):e22577. doi:
10.1371/journal.pone.0022577. [PMID: 21826197] - E Melendez, M Bidet, J L Reyes, S Martial, O Barbier, M Tauc, E Sanchez, P Poujeol. New evidence of a dihydropyridine-activated cationic channel in the MDCK cell line.
Nephron. Physiology.
2011; 118(4):p73-81. doi:
10.1159/000325467. [PMID: 21502768] - Rodrigo Alzamora, Fiona O'Mahony, Wing-Hung Ko, Tiffany Wai-Nga Yip, Derek Carter, Mustapha Irnaten, Brian Joseph Harvey. Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels.
Frontiers in physiology.
2011; 2(?):33. doi:
10.3389/fphys.2011.00033. [PMID: 21747769] - Chayne L Piscitelli, Harini Krishnamurthy, Eric Gouaux. Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site.
Nature.
2010 Dec; 468(7327):1129-32. doi:
10.1038/nature09581. [PMID: 21179170] - Suresh Kumar Kailasa, Hui-Fen Wu. Surface modified silver selinide nanoparticles as extracting probes to improve peptide/protein detection via nanoparticles-based liquid phase microextraction coupled with MALDI mass spectrometry.
Talanta.
2010 Dec; 83(2):527-34. doi:
10.1016/j.talanta.2010.09.040. [PMID: 21111169] - Takashi Kadono, Daniel Tran, Rafik Errakhi, Takuya Hiramatsu, Patrice Meimoun, Joël Briand, Mari Iwaya-Inoue, Tomonori Kawano, François Bouteau. Increased anion channel activity is an unavoidable event in ozone-induced programmed cell death.
PloS one.
2010 Oct; 5(10):e13373. doi:
10.1371/journal.pone.0013373. [PMID: 20967217] - Jessica Papuga, Céline Hoffmann, Monika Dieterle, Danièle Moes, Flora Moreau, Stéphane Tholl, André Steinmetz, Clément Thomas. Arabidopsis LIM proteins: a family of actin bundlers with distinct expression patterns and modes of regulation.
The Plant cell.
2010 Sep; 22(9):3034-52. doi:
10.1105/tpc.110.075960. [PMID: 20817848] - Jonna Nykky, Jenni E Tuusa, Sanna Kirjavainen, Matti Vuento, Leona Gilbert. Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine.
International journal of nanomedicine.
2010 Aug; 5(?):417-28. doi:
10.2147/ijn.s10579. [PMID: 20957163] - James K R Kendall, Benjamin R G Johnson, Philip H Symonds, Guiseppi Imperato, Richard J Bushby, James D Gwyer, Cees van Berkel, Stephen D Evans, Lars J C Jeuken. Effect of the structure of cholesterol-based tethered bilayer lipid membranes on ionophore activity.
Chemphyschem : a European journal of chemical physics and physical chemistry.
2010 Jul; 11(10):2191-8. doi:
10.1002/cphc.200900917. [PMID: 20512836] - Igor Vorobyov, Borislava Bekker, Toby W Allen. Electrostatics of deformable lipid membranes.
Biophysical journal.
2010 Jun; 98(12):2904-13. doi:
10.1016/j.bpj.2010.03.046. [PMID: 20550903] - Michael Henkel, David Mitzner, Peter Henklein, Franz-Josef Meyer-Almes, Anna Moroni, Mattia L Difrancesco, Leonhard M Henkes, Michael Kreim, Stefan M Kast, Ulrich Schubert, Gerhard Thiel. The proapoptotic influenza A virus protein PB1-F2 forms a nonselective ion channel.
PloS one.
2010 Jun; 5(6):e11112. doi:
10.1371/journal.pone.0011112. [PMID: 20559552] - Seiji Miyauchi, Elangovan Gopal, Ellappan Babu, Sonne R Srinivas, Yoshiyuki Kubo, Nagavedi S Umapathy, Santoshanand V Thakkar, Vadivel Ganapathy, Puttur D Prasad. Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.
Biochimica et biophysica acta.
2010 Jun; 1798(6):1164-71. doi:
10.1016/j.bbamem.2010.03.002. [PMID: 20211600] - B Chakraborty, S Biswas, S Mondal, T Bera. Stage specific developmental changes in the mitochondrial and surface membrane associated redox systems of Leishmania donovani promastigote and amastigote.
Biochemistry. Biokhimiia.
2010 Apr; 75(4):494-518. doi:
10.1134/s0006297910040140. [PMID: 20618140] - Mohammed Aldakkak, David F Stowe, Qunli Cheng, Wai-Meng Kwok, Amadou K S Camara. Mitochondrial matrix K+ flux independent of large-conductance Ca2+-activated K+ channel opening.
American journal of physiology. Cell physiology.
2010 Mar; 298(3):C530-41. doi:
10.1152/ajpcell.00468.2009. [PMID: 20053924] - Joseph R McDermott, Xuan Jiang, Lauren C Beene, Barry P Rosen, Zijuan Liu. Pentavalent methylated arsenicals are substrates of human AQP9.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
2010 Feb; 23(1):119-27. doi:
10.1007/s10534-009-9273-9. [PMID: 19802720] - Luciene R Carraro-Lacroix, Lucília M A Lessa, Camila N A Bezerra, Thaíssa D Pessoa, Jackson Souza-Menezes, Marcelo M Morales, Adriana C C Girardi, Gerhard Malnic. Role of CFTR and ClC-5 in modulating vacuolar H+-ATPase activity in kidney proximal tubule.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2010; 26(4-5):563-76. doi:
10.1159/000322324. [PMID: 21063094] - H V Danylovych, Iu V Danylovych, V F Horchev. [Registration of K(+)-equilibrium potential in myometrium cell plasma membrane and study of its modulation of NO(x) and H2O2, using flow cytometry method].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2010 Jan; 82(1):52-61. doi:
NULL. [PMID: 20684228] - Yasuo Kagawa. ATP synthase: from single molecule to human bioenergetics.
Proceedings of the Japan Academy. Series B, Physical and biological sciences.
2010; 86(7):667-93. doi:
10.2183/pjab.86.667. [PMID: 20689227] - Sabina Passamonti, Federica Tramer, Elisa Petrussa, Enrico Braidot, Angelo Vianello. Electrogenic bromosulfalein transport in isolated membrane vesicles: implementation in both animal and plant preparations for the study of flavonoid transporters.
Methods in molecular biology (Clifton, N.J.).
2010; 643(?):307-35. doi:
10.1007/978-1-60761-723-5_21. [PMID: 20552460] - Colin W Taylor, David L Prole, Taufiq Rahman. Ca(2+) channels on the move.
Biochemistry.
2009 Dec; 48(51):12062-80. doi:
10.1021/bi901739t. [PMID: 19928968] - Verónica Nin, Julio A Hernández, Silvia Chifflet. Hyperpolarization of the plasma membrane potential provokes reorganization of the actin cytoskeleton and increases the stability of adherens junctions in bovine corneal endothelial cells in culture.
Cell motility and the cytoskeleton.
2009 Dec; 66(12):1087-99. doi:
10.1002/cm.20416. [PMID: 19753628] - Gorazd Pucihar, Tadej Kotnik, Damijan Miklavcic. Measuring the induced membrane voltage with Di-8-ANEPPS.
Journal of visualized experiments : JoVE.
2009 Nov; ?(33):. doi:
10.3791/1659. [PMID: 19927116] - Jingsheng Xia, Dejian Ren. The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent.
Reproductive biology and endocrinology : RB&E.
2009 Oct; 7(?):119. doi:
10.1186/1477-7827-7-119. [PMID: 19860887] - Chenxi Zhou, Mario Tiberi, Binhui Liang, Seth L Alper, Jay M Baltz. HCO3(-)/Cl(-) exchange inactivation and reactivation during mouse oocyte meiosis correlates with MEK/MAPK-regulated Ae2 plasma membrane localization.
PloS one.
2009 Oct; 4(10):e7417. doi:
10.1371/journal.pone.0007417. [PMID: 19823673] - Walid Fayad, Mårten Fryknäs, Slavica Brnjic, Maria Hägg Olofsson, Rolf Larsson, Stig Linder. Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.
PloS one.
2009 Oct; 4(10):e7238. doi:
10.1371/journal.pone.0007238. [PMID: 19798419] - Jesper S Hansen, Mark Perry, Jörg Vogel, Jesper S Groth, Thomas Vissing, Marianne S Larsen, Oliver Geschke, Jenny Emneús, Henrik Bohr, Claus H Nielsen. Large scale biomimetic membrane arrays.
Analytical and bioanalytical chemistry.
2009 Oct; 395(3):719-27. doi:
10.1007/s00216-009-3010-7. [PMID: 19672582] - Toshiyuki Nakamura, Atsushi Watanabe, Takahiro Fujino, Takashi Hosono, Makoto Michikawa. Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells.
Molecular neurodegeneration.
2009 Aug; 4(?):35. doi:
10.1186/1750-1326-4-35. [PMID: 19695092] - Christian Kepplinger, Ines Höfer, Claudia Steinem. Impedance analysis of valinomycin activity in nano-BLMs.
Chemistry and physics of lipids.
2009 Aug; 160(2):109-13. doi:
10.1016/j.chemphyslip.2009.05.001. [PMID: 19446541] - N-E Leo Saris, Maria A Andersson, Raimo Mikkola, Leif C Andersson, Vera V Teplova, Pavel A Grigoriev, Mirja S Salkinoja-Salonen. Microbial toxin's effect on mitochondrial survival by increasing K+ uptake.
Toxicology and industrial health.
2009 Aug; 25(7):441-6. doi:
10.1177/0748233709103405. [PMID: 19736254] - Alexandre D T Costa, Marco A Krieger. Evidence for an ATP-sensitive K+ channel in mitoplasts isolated from Trypanosoma cruzi and Crithidia fasciculata.
International journal for parasitology.
2009 Jul; 39(9):955-61. doi:
10.1016/j.ijpara.2009.01.002. [PMID: 19504755] - Alena Siarheyeva, Frances J Sharom. The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites.
The Biochemical journal.
2009 Apr; 419(2):317-28. doi:
10.1042/bj20081364. [PMID: 19132955] - Vandana Kalia, Rajni Miglani, Kedar P Purnapatre, Tarun Mathur, Smita Singhal, Seema Khan, Sreedhara R Voleti, Dilip J Upadhyay, Kulvinder Singh Saini, Ashok Rattan, V Samuel Raj. Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
Antimicrobial agents and chemotherapy.
2009 Apr; 53(4):1427-33. doi:
10.1128/aac.00887-08. [PMID: 19075051] - Jolanta Skalska, Piotr Bednarczyk, Marta Piwońska, Bogusz Kulawiak, Grzegorz Wilczynski, Krzysztof Dołowy, Alexei P Kudin, Wolfram S Kunz, Adam Szewczyk. Calcium ions regulate K⁺ uptake into brain mitochondria: the evidence for a novel potassium channel.
International journal of molecular sciences.
2009 Mar; 10(3):1104-20. doi:
10.3390/ijms10031104. [PMID: 19399240] - Christina Smith, Donald F Gibson, Jonathan F Tait. Transmembrane voltage regulates binding of annexin V and lactadherin to cells with exposed phosphatidylserine.
BMC biochemistry.
2009 Feb; 10(?):5. doi:
10.1186/1471-2091-10-5. [PMID: 19222854] - Alberto Bertolini, Carlo Peresson, Elisa Petrussa, Enrico Braidot, Sabina Passamonti, Francesco Macrì, Angelo Vianello. Identification and localization of the bilitranslocase homologue in white grape berries (Vitis vinifera L.) during ripening.
Journal of experimental botany.
2009; 60(13):3861-71. doi:
10.1093/jxb/erp225. [PMID: 19596699] - Jian Liu, Mahamud Subir, Kim Nguyen, Kenneth B Eisenthal. Second harmonic studies of ions crossing liposome membranes in real time.
The journal of physical chemistry. B.
2008 Dec; 112(48):15263-6. doi:
10.1021/jp806690z. [PMID: 18989915] - Francesca Oppedisano, Cesare Indiveri. Reconstitution into liposomes of the B degrees -like glutamine-neutral amino acid transporter from renal cell plasma membrane.
Biochimica et biophysica acta.
2008 Oct; 1778(10):2258-65. doi:
10.1016/j.bbamem.2008.05.011. [PMID: 18572012] - Robert F Roskamp, Inga K Vockenroth, Nancy Eisenmenger, Julia Braunagel, Ingo Köper. Functional tethered bilayer lipid membranes on aluminum oxide.
Chemphyschem : a European journal of chemical physics and physical chemistry.
2008 Sep; 9(13):1920-4. doi:
10.1002/cphc.200800248. [PMID: 18704903] - Andreas Hennig, Gregory J Gabriel, Gregory N Tew, Stefan Matile. Stimuli-responsive polyguanidino-oxanorbornene membrane transporters as multicomponent sensors in complex matrices.
Journal of the American Chemical Society.
2008 Aug; 130(31):10338-44. doi:
10.1021/ja802587j. [PMID: 18624407] - E Braidot, E Petrussa, A Bertolini, C Peresson, P Ermacora, N Loi, M Terdoslavich, S Passamonti, F Macrì, A Vianello. Evidence for a putative flavonoid translocator similar to mammalian bilitranslocase in grape berries (Vitis vinifera L.) during ripening.
Planta.
2008 Jun; 228(1):203-13. doi:
10.1007/s00425-008-0730-4. [PMID: 18365247] - Robert Leonardo Galvez Rojas, Mariana Lins Frossard, Maria Cristina Machado Motta, Ariel Mariano Silber. L-Proline uptake in Crithidia deanei is influenced by its endosymbiont bacterium.
FEMS microbiology letters.
2008 Jun; 283(1):15-22. doi:
10.1111/j.1574-6968.2008.01125.x. [PMID: 18397288] - Cheol Nam Park, Jung Min Lee, Dongho Lee, Beom Seok Kim. Antifungal activity of valinomycin, a peptide antibiotic produced by Streptomyces sp. Strain M10 antagonistic to Botrytis cinerea.
Journal of microbiology and biotechnology.
2008 May; 18(5):880-4. doi:
. [PMID: 18633285] - Yoav Adam, Robert H Edwards, Shimon Schuldiner. Expression and function of the rat vesicular monoamine transporter 2.
American journal of physiology. Cell physiology.
2008 Apr; 294(4):C1004-11. doi:
10.1152/ajpcell.00348.2007. [PMID: 18287335]
