Diethylphosphate (BioDeep_00000001668)
Secondary id: BioDeep_00001868072
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
Diethyl phosphate, chromium (+3) salt
化学式: C4H11O4P (154.0395)
中文名称: 磷酸二乙酯
谱图信息:
最多检出来源 Homo sapiens(blood) 8.44%
Reviewed
Last reviewed on 2024-07-29.
Cite this Page
Diethylphosphate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/diethylphosphate (retrieved
2024-12-31) (BioDeep RN: BioDeep_00000001668). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CCOP(=O)(O)OCC
InChI: InChI=1S/C4H11O4P/c1-3-7-9(5,6)8-4-2/h3-4H2,1-2H3,(H,5,6)
描述信息
Diethylphosphate is product of metabolism and of environmental degradation of Chlorpyrifos (CPF; a commonly used diethylphosphorothionate organophosphorus (OP) insecticide) and are routinely measured in urine as biomarkers of exposure. (PMID: 17590257). [HMDB]
Diethylphosphate is product of metabolism and of environmental degradation of Chlorpyrifos (CPF; a commonly used diethylphosphorothionate organophosphorus (OP) insecticide) and are routinely measured in urine as biomarkers of exposure. (PMID: 17590257).
KEIO_ID D141
Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos.
同义名列表
20 个代谢物同义名
Diethyl phosphate, chromium (+3) salt; Diethyl hydrogen phosphoric acid; Diethyl phosphate, sodium salt; O,O-Diethyl hydrogen phosphate; Phosphoric acid diethyl ester; Diethyl hydrogen phosphate; O,O-Diethylphosphoric acid; Diethyl phosphoric acid; diethoxyphosphinic acid; Diethyl acid phosphate; Diethylphosphoric acid; O,O-Diethyl phosphate; O,O-Diethylphosphate; Di-ethyl phosphate; Diethyl phosphate; Diethylphosphate; ethyl phosphate; DEP; DPF; Diethylphosphoric acid
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:27708
- KEGG: C06608
- PubChem: 654
- HMDB: HMDB0012209
- Metlin: METLIN62856
- ChEMBL: CHEMBL1232324
- foodb: FDB028854
- chemspider: 634
- CAS: 598-02-7
- MoNA: KO000683
- MoNA: KO000680
- MoNA: KO000681
- MoNA: KO000682
- MoNA: KO000679
- PMhub: MS000000951
- PDB-CCD: DPF
- 3DMET: B00995
- NIKKAJI: J1.649G
- RefMet: Diethylphosphate
- medchemexpress: HY-101417
- PubChem: 8834
- KNApSAcK: 27708
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
5 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(5)
- parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate - paraoxon degradation:
H2O + paraoxon ⟶ 4-nitrophenol + H+ + diethylphosphate - superpathway of parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate - diethylphosphate degradation:
H2O + diethylphosphate ⟶ H+ + ethanol + ethylphosphate - parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tamar Shamai Yamin, Moran Madmon, Ariel Hindi, Avital Shifrovich, Hagit Prihed, Merav Blanca, Avi Weissberg. Enhanced LC-ESI-MS/MS Sensitivity by Cationic Derivatization of Organophosphorus Acids.
Molecules (Basel, Switzerland).
2023 Aug; 28(16):. doi:
10.3390/molecules28166090. [PMID: 37630342] - Fang-Wei Yang, Bing Fang, Guo-Fang Pang, Ming Zhang, Fa-Zheng Ren. Triazophos and its metabolite diethyl phosphate have different effects on endocrine hormones and gut health in rats.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2021; 56(6):566-576. doi:
10.1080/03601234.2021.1922042. [PMID: 34038317] - Fang-Wei Yang, Guo-Ping Zhao, Fa-Zheng Ren, Guo-Fang Pang, Yi-Xuan Li. Assessment of the endocrine-disrupting effects of diethyl phosphate, a nonspecific metabolite of organophosphorus pesticides, by in vivo and in silico approaches.
Environment international.
2020 02; 135(?):105383. doi:
10.1016/j.envint.2019.105383. [PMID: 31835022] - Sukesh Narayan Sinha, Ungarala Venkat Ramakrishna, P K Sinha, C P Thakur. A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar-A comprehensive investigation on factors of toxicity.
PloS one.
2020; 15(12):e0244798. doi:
10.1371/journal.pone.0244798. [PMID: 33382820] - Nayana K Jayatilaka, Paula Restrepo, Zachary Davis, Meghan Vidal, Antonia M Calafat, Maria Ospina. Quantification of 16 urinary biomarkers of exposure to flame retardants, plasticizers, and organophosphate insecticides for biomonitoring studies.
Chemosphere.
2019 Nov; 235(?):481-491. doi:
10.1016/j.chemosphere.2019.06.181. [PMID: 31272008] - Antonio F Hernández, David Lozano-Paniagua, Beatriz González-Alzaga, Matthaios P Kavvalakis, Manolis N Tzatzarakis, Inmaculada López-Flores, Clemente Aguilar-Garduño, Rafael A Caparros-Gonzalez, Aristidis M Tsatsakis, Marina Lacasaña. Biomonitoring of common organophosphate metabolites in hair and urine of children from an agricultural community.
Environment international.
2019 10; 131(?):104997. doi:
10.1016/j.envint.2019.104997. [PMID: 31362151] - Fangwei Yang, Jinwang Li, Guofang Pang, Fazheng Ren, Bing Fang. Effects of Diethyl Phosphate, a Non-Specific Metabolite of Organophosphorus Pesticides, on Serum Lipid, Hormones, Inflammation, and Gut Microbiota.
Molecules (Basel, Switzerland).
2019 May; 24(10):. doi:
10.3390/molecules24102003. [PMID: 31137755] - Sukesh Narayan Sinha, Venkat Reddy Banda. Correlation of pesticide exposure from dietary intake and bio-monitoring: The different sex and socio-economic study of children.
Ecotoxicology and environmental safety.
2018 10; 162(?):170-177. doi:
10.1016/j.ecoenv.2018.06.086. [PMID: 29990728] - Sunwook Kim, Maury A Nussbaum, Paul J Laurienti, Haiying Chen, Sara A Quandt, Dana Boyd Barr, Thomas A Arcury. Exploring Associations Between Postural Balance and Levels of Urinary Organophosphorus Pesticide Metabolites.
Journal of occupational and environmental medicine.
2018 02; 60(2):174-179. doi:
10.1097/jom.0000000000001194. [PMID: 29023345] - Yiwen Wang, Yan Zhang, Lin Ji, Yi Hu, Jingjing Zhang, Caifeng Wang, Guodong Ding, Limei Chen, Michihiro Kamijima, Jun Ueyama, Yu Gao, Ying Tian. Prenatal and postnatal exposure to organophosphate pesticides and childhood neurodevelopment in Shandong, China.
Environment international.
2017 11; 108(?):119-126. doi:
10.1016/j.envint.2017.08.010. [PMID: 28843140] - Yiwen Wang, Limei Chen, Caifeng Wang, Yi Hum, Yu Gao, Yijun Zhou, Rong Shi, Yan Zhang, Michihiro Kamijima, Jun Ueyama, Ying Tian. Association Between Organophosphate Pesticide Exposure and Thyroid Hormones in Pregnant Women.
Epidemiology (Cambridge, Mass.).
2017 10; 28 Suppl 1(?):S35-S40. doi:
10.1097/ede.0000000000000721. [PMID: 29028673] - Jun Ueyama, Kouji H Harada, Akio Koizumi, Yuka Sugiura, Takaaki Kondo, Isao Saito, Michihiro Kamijima. Temporal Levels of Urinary Neonicotinoid and Dialkylphosphate Concentrations in Japanese Women Between 1994 and 2011.
Environmental science & technology.
2015 Dec; 49(24):14522-8. doi:
10.1021/acs.est.5b03062. [PMID: 26556224] - Rachel Raanan, Kim G Harley, John R Balmes, Asa Bradman, Michael Lipsett, Brenda Eskenazi. Early-life exposure to organophosphate pesticides and pediatric respiratory symptoms in the CHAMACOS cohort.
Environmental health perspectives.
2015 Feb; 123(2):179-85. doi:
10.1289/ehp.1408235. [PMID: 25369257] - Jun Ueyama, Isao Saito, Ayuko Takaishi, Hiroshi Nomura, Mai Inoue, Aya Osaka, Yuka Sugiura, Yumi Hayashi, Shinya Wakusawa, Hiroko Ogi, Kimio Inuzuka, Michihiro Kamijima, Takaaki Kondo. A revised method for determination of dialkylphosphate levels in human urine by solid-phase extraction and liquid chromatography with tandem mass spectrometry: application to human urine samples from Japanese children.
Environmental health and preventive medicine.
2014 Nov; 19(6):405-13. doi:
10.1007/s12199-014-0407-5. [PMID: 25293697] - Ying Zhang, Song Han, Duohong Liang, Xinzhu Shi, Fengzhi Wang, Wei Liu, Li Zhang, Lixin Chen, Yingzi Gu, Ying Tian. Prenatal exposure to organophosphate pesticides and neurobehavioral development of neonates: a birth cohort study in Shenyang, China.
PloS one.
2014; 9(2):e88491. doi:
10.1371/journal.pone.0088491. [PMID: 24551109] - T Berman, R Goldsmith, T Göen, J Spungen, L Novack, H Levine, Y Amitai, T Shohat, I Grotto. Urinary concentrations of organophosphate pesticide metabolites in adults in Israel: demographic and dietary predictors.
Environment international.
2013 Oct; 60(?):183-9. doi:
10.1016/j.envint.2013.08.008. [PMID: 24064379] - Lesliam Quirós-Alcalá, Asa Bradman, Kimberly Smith, Gayanga Weerasekera, Martins Odetokun, Dana Boyd Barr, Marcia Nishioka, Rosemary Castorina, Alan E Hubbard, Mark Nicas, S Katharine Hammond, Thomas E McKone, Brenda Eskenazi. Organophosphorous pesticide breakdown products in house dust and children's urine.
Journal of exposure science & environmental epidemiology.
2012 Nov; 22(6):559-68. doi:
10.1038/jes.2012.46. [PMID: 22781438] - Pei Wang, Ying Tian, Xiao-Jin Wang, Yu Gao, Rong Shi, Guo-Quan Wang, Guo-Hua Hu, Xiao-Ming Shen. Organophosphate pesticide exposure and perinatal outcomes in Shanghai, China.
Environment international.
2012 Jul; 42(?):100-4. doi:
10.1016/j.envint.2011.04.015. [PMID: 21601922] - Jun Ueyama, Isao Saito, Takaaki Kondo, Tomoko Taki, Akiko Kimata, Shun Saito, Yuki Ito, Katsuyuki Murata, Toyoto Iwata, Masahiro Gotoh, Eiji Shibata, Shinya Wakusawa, Michihiro Kamijima. Urinary concentrations of organophosphorus insecticide metabolites in Japanese workers.
Chemosphere.
2012 Jun; 87(11):1403-9. doi:
10.1016/j.chemosphere.2012.02.048. [PMID: 22455950] - Matthaios P Kavvalakis, Aristidis M Tsatsakis. The atlas of dialkylphosphates; assessment of cumulative human organophosphorus pesticides' exposure.
Forensic science international.
2012 May; 218(1-3):111-22. doi:
10.1016/j.forsciint.2011.10.019. [PMID: 22018851] - Alison L Clune, P Barry Ryan, Dana Boyd Barr. Have regulatory efforts to reduce organophosphorus insecticide exposures been effective?.
Environmental health perspectives.
2012 Apr; 120(4):521-5. doi:
10.1289/ehp.1104323. [PMID: 22251442] - Toshiaki Yoshida, Jin Yoshida. Simultaneous analytical method for urinary metabolites of organophosphorus compounds and moth repellents in general population.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Jan; 880(1):66-73. doi:
10.1016/j.jchromb.2011.11.018. [PMID: 22130501] - Paloma I Beamer, Robert A Canales, Alesia C Ferguson, James O Leckie, Asa Bradman. Relative pesticide and exposure route contribution to aggregate and cumulative dose in young farmworker children.
International journal of environmental research and public health.
2012 01; 9(1):73-96. doi:
10.3390/ijerph9010073. [PMID: 22470279] - Xiao-Fei Tian, Zhen Fang, Dan Jiang, Xi-Yan Sun. Pretreatment of microcrystalline cellulose in organic electrolyte solutions for enzymatic hydrolysis.
Biotechnology for biofuels.
2011 Nov; 4(1):53. doi:
10.1186/1754-6834-4-53. [PMID: 22099703] - Yoshikazu Arai, Jun Ohgane, Shintaro Yagi, Rie Ito, Yusuke Iwasaki, Koichi Saito, Kazuhiko Akutsu, Satoshi Takatori, Rie Ishii, Rumiko Hayashi, Shun-Ichiro Izumi, Norihiro Sugino, Fumio Kondo, Masakazu Horie, Hiroyuki Nakazawa, Tsunehisa Makino, Kunio Shiota. Epigenetic assessment of environmental chemicals detected in maternal peripheral and cord blood samples.
The Journal of reproduction and development.
2011 Sep; 57(4):507-17. doi:
10.1262/jrd.11-034a. [PMID: 21606628] - Dana Boyd Barr, Lee-Yang Wong, Roberto Bravo, Gayanga Weerasekera, Martins Odetokun, Paula Restrepo, Do-Gyun Kim, Carolina Fernandez, Ralph D Whitehead, Jose Perez, Maribel Gallegos, Bryan L Williams, Larry L Needham. Urinary concentrations of dialkylphosphate metabolites of organophosphorus pesticides: National Health and Nutrition Examination Survey 1999-2004.
International journal of environmental research and public health.
2011 08; 8(8):3063-98. doi:
10.3390/ijerph8083063. [PMID: 21909292] - Maryse F Bouchard, Jonathan Chevrier, Kim G Harley, Katherine Kogut, Michelle Vedar, Norma Calderon, Celina Trujillo, Caroline Johnson, Asa Bradman, Dana Boyd Barr, Brenda Eskenazi. Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children.
Environmental health perspectives.
2011 Aug; 119(8):1189-95. doi:
10.1289/ehp.1003185. [PMID: 21507776] - Stephanie M Engel, James Wetmur, Jia Chen, Chenbo Zhu, Dana Boyd Barr, Richard L Canfield, Mary S Wolff. Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood.
Environmental health perspectives.
2011 Aug; 119(8):1182-8. doi:
10.1289/ehp.1003183. [PMID: 21507778] - Asa Bradman, Rosemary Castorina, Dana Boyd Barr, Jonathan Chevrier, Martha E Harnly, Ellen A Eisen, Thomas E McKone, Kim Harley, Nina Holland, Brenda Eskenazi. Determinants of organophosphorus pesticide urinary metabolite levels in young children living in an agricultural community.
International journal of environmental research and public health.
2011 04; 8(4):1061-83. doi:
10.3390/ijerph8041061. [PMID: 21695029] - Pornpimol Kongtip, Sirinnapa Changfuang, Witaya Yoosook, Suttinun Chantanakul, Dusit Sujirarat. Ethion exposure and biological monitoring in vegetable farmers.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2011 Mar; 94(3):286-94. doi:
. [PMID: 21560835] - Yan Zhang, Sha Zhu, Yu Gao, Xiao-jin Wang, Tao Chen, You Yang, Guo-quan Wang, Guo-hua Hu, Rong Shi, Ping Jin, Ying Tian. [A case-control study on correlation of pesticide exposure with childhood acute leukemia].
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].
2011 Jan; 45(1):41-6. doi:
. [PMID: 21418818] - Kim G Harley, Karen Huen, Raul Aguilar Schall, Nina T Holland, Asa Bradman, Dana Boyd Barr, Brenda Eskenazi. Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women.
PloS one.
2011; 6(8):e23923. doi:
10.1371/journal.pone.0023923. [PMID: 21904599] - Gary Brodeur, Elizabeth Yau, Kimberly Badal, John Collier, K B Ramachandran, Subramanian Ramakrishnan. Chemical and physicochemical pretreatment of lignocellulosic biomass: a review.
Enzyme research.
2011; 2011(?):787532. doi:
10.4061/2011/787532. [PMID: 21687609] - Brenda Eskenazi, Karen Huen, Amy Marks, Kim G Harley, Asa Bradman, Dana Boyd Barr, Nina Holland. PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero.
Environmental health perspectives.
2010 Dec; 118(12):1775-81. doi:
10.1289/ehp.1002234. [PMID: 21126941] - Amy R Marks, Kim Harley, Asa Bradman, Katherine Kogut, Dana Boyd Barr, Caroline Johnson, Norma Calderon, Brenda Eskenazi. Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study.
Environmental health perspectives.
2010 Dec; 118(12):1768-74. doi:
10.1289/ehp.1002056. [PMID: 21126939] - Martins S Odetokun, M Angela Montesano, Gayanga Weerasekera, Ralph D Whitehead, Larry L Needham, Dana Boyd Barr. Quantification of dialkylphosphate metabolites of organophosphorus insecticides in human urine using 96-well plate sample preparation and high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Oct; 878(27):2567-74. doi:
10.1016/j.jchromb.2010.04.027. [PMID: 20494630] - Julia Blanco-Muñoz, Magally Mayanin Morales, Marina Lacasaña, Clemente Aguilar-Garduño, Susana Bassol, Mariano E Cebrián. Exposure to organophosphate pesticides and male hormone profile in floriculturist of the state of Morelos, Mexico.
Human reproduction (Oxford, England).
2010 Jul; 25(7):1787-95. doi:
10.1093/humrep/deq082. [PMID: 20435691] - Raul Harari, Jordi Julvez, Katsuyuki Murata, Dana Barr, David C Bellinger, Frodi Debes, Philippe Grandjean. Neurobehavioral deficits and increased blood pressure in school-age children prenatally exposed to pesticides.
Environmental health perspectives.
2010 Jun; 118(6):890-6. doi:
10.1289/ehp.0901582. [PMID: 20185383] - Jun Ueyama, Michihiro Kamijima, Takaaki Kondo, Kenji Takagi, Eiji Shibata, Takaaki Hasegawa, Shinya Wakusawa, Tomoko Taki, Masahiro Gotoh, Isao Saito. Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 May; 878(17-18):1257-63. doi:
10.1016/j.jchromb.2010.02.005. [PMID: 20207202] - Andrea L Busby-Hjerpe, James A Campbell, Jordan Ned Smith, Sookwang Lee, Torka S Poet, Dana B Barr, Charles Timchalk. Comparative pharmacokinetics of chlorpyrifos versus its major metabolites following oral administration in the rat.
Toxicology.
2010 Jan; 268(1-2):55-63. doi:
10.1016/j.tox.2009.11.022. [PMID: 19963030] - Kathryn M Atherton, Faith M Williams, Francisco J Egea González, Richard Glass, Steve Rushton, Peter G Blain, Elaine Mutch. DNA damage in horticultural farmers: a pilot study showing an association with organophosphate pesticide exposure.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2009 Nov; 14(7):443-51. doi:
10.3109/13547500903137265. [PMID: 19863182] - Thomas A Arcury, Joseph G Grzywacz, Haiying Chen, Quirina M Vallejos, Leonardo Galván, Lara E Whalley, Scott Isom, Dana B Barr, Sara A Quandt. Variation across the agricultural season in organophosphorus pesticide urinary metabolite levels for Latino farmworkers in eastern North Carolina: project design and descriptive results.
American journal of industrial medicine.
2009 Jul; 52(7):539-50. doi:
10.1002/ajim.20703. [PMID: 19517490] - Gayanga Weerasekera, Kimberly D Smith, Lesliam Quirós-Alcalá, Carolina Fernandez, Asa Bradman, Brenda Eskenazi, Larry L Needham, Dana B Barr. A mass spectrometry-based method to measure dialkylphosphate degradation products of organophosphorous insecticides in dust and orange juice.
Journal of environmental monitoring : JEM.
2009 Jul; 11(7):1345-51. doi:
10.1039/b821841b. [PMID: 20449223] - Qiang Li, Yu-Cai He, Mo Xian, Gao Jun, Xin Xu, Jian-Ming Yang, Liang-Zhi Li. Improving enzymatic hydrolysis of wheat straw using ionic liquid 1-ethyl-3-methyl imidazolium diethyl phosphate pretreatment.
Bioresource technology.
2009 Jul; 100(14):3570-5. doi:
10.1016/j.biortech.2009.02.040. [PMID: 19329299] - Sandra Yucra, Manuel Gasco, Julio Rubio, Gustavo F Gonzales. Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters.
Environmental health : a global access science source.
2008 Nov; 7(?):59. doi:
10.1186/1476-069x-7-59. [PMID: 19014632] - Jan Hajduch, Ghilsoo Nam, Eun Ju Kim, Roland Fröhlich, John A Hanover, Kenneth L Kirk. A convenient synthesis of the C-1-phosphonate analogue of UDP-GlcNAc and its evaluation as an inhibitor of O-linked GlcNAc transferase (OGT).
Carbohydrate research.
2008 Feb; 343(2):189-95. doi:
10.1016/j.carres.2007.10.027. [PMID: 18039537] - Gayanga Weerasekera, Kimberly D Smith, Larry L Needham, Dana B Barr. A rapid, cost-effective method for analyzing organophosphorus pesticide metabolites in human urine for counter-terrorism response.
Journal of analytical toxicology.
2008 Jan; 32(1):106-15. doi:
10.1093/jat/32.1.106. [PMID: 18269802] - Charles Timchalk, Andrea Busby, James A Campbell, Larry L Needham, Dana B Barr. Comparative pharmacokinetics of the organophosphorus insecticide chlorpyrifos and its major metabolites diethylphosphate, diethylthiophosphate and 3,5,6-trichloro-2-pyridinol in the rat.
Toxicology.
2007 Jul; 237(1-3):145-157. doi:
10.1016/j.tox.2007.05.007. [PMID: 17590257] - Stephanie M Engel, Gertrud S Berkowitz, Dana B Barr, Susan L Teitelbaum, Jodi Siskind, Stefanie J Meisel, James G Wetmur, Mary S Wolff. Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort.
American journal of epidemiology.
2007 Jun; 165(12):1397-404. doi:
10.1093/aje/kwm029. [PMID: 17406008] - Wei-Chao Lin, Chang-Yuan Hsieh, Ho-Yuan Chang. Improved analysis of dialkylphosphates in urine using strong anion exchange disk extraction and in-vial derivatization.
Journal of separation science.
2007 Jun; 30(9):1326-33. doi:
10.1002/jssc.200600302. [PMID: 17623475] - Jun Ueyama, Dong Wang, Takaaki Kondo, Isao Saito, Kenji Takagi, Kenzo Takagi, Michihiro Kamijima, Tamie Nakajima, Ken-Ichi Miyamoto, Shinya Wakusawa, Takaaki Hasegawa. Toxicity of diazinon and its metabolites increases in diabetic rats.
Toxicology letters.
2007 May; 170(3):229-37. doi:
10.1016/j.toxlet.2007.03.010. [PMID: 17442507] - Brenda Eskenazi, Amy R Marks, Asa Bradman, Kim Harley, Dana B Barr, Caroline Johnson, Norma Morga, Nicholas P Jewell. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children.
Environmental health perspectives.
2007 May; 115(5):792-8. doi:
10.1289/ehp.9828. [PMID: 17520070] - Dana B Barr, Jürgen Angerer. Potential uses of biomonitoring data: a case study using the organophosphorus pesticides chlorpyrifos and malathion.
Environmental health perspectives.
2006 Nov; 114(11):1763-9. doi:
10.1289/ehp.9062. [PMID: 17107865] - Thomas A Arcury, Joseph G Grzywacz, Stephen W Davis, Dana B Barr, Sara A Quandt. Organophosphorus pesticide urinary metabolite levels of children in farmworker households in eastern North Carolina.
American journal of industrial medicine.
2006 Sep; 49(9):751-60. doi:
10.1002/ajim.20354. [PMID: 16804908] - Nina Holland, Clement Furlong, Maria Bastaki, Rebecca Richter, Asa Bradman, Karen Huen, Kenneth Beckman, Brenda Eskenazi. Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns.
Environmental health perspectives.
2006 Jul; 114(7):985-91. doi:
10.1289/ehp.8540. [PMID: 16835048] - Gloria D Coronado, Eric M Vigoren, Beti Thompson, William C Griffith, Elaine M Faustman. Organophosphate pesticide exposure and work in pome fruit: evidence for the take-home pesticide pathway.
Environmental health perspectives.
2006 Jul; 114(7):999-1006. doi:
10.1289/ehp.8620. [PMID: 16835050] - Jun Ueyama, Isao Saito, Michihiro Kamijima, Tamie Nakajima, Masahiro Gotoh, Takayoshi Suzuki, Eiji Shibata, Takaaki Kondo, Kenji Takagi, Ken-ichi Miyamoto, Junki Takamatsu, Takaaki Hasegawa, Kenzo Takagi. Simultaneous determination of urinary dialkylphosphate metabolites of organophosphorus pesticides using gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Feb; 832(1):58-66. doi:
10.1016/j.jchromb.2005.12.030. [PMID: 16427368] - S Dulaurent, F Saint-Marcoux, P Marquet, G Lachâtre. Simultaneous determination of six dialkylphosphates in urine by liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Feb; 831(1-2):223-9. doi:
10.1016/j.jchromb.2005.12.012. [PMID: 16412711] - Wolfgang Bicker, Michael Lämmerhofer, Dieter Genser, Heinrich Kiss, Wolfgang Lindner. A case study of acute human chlorpyrifos poisoning: novel aspects on metabolism and toxicokinetics derived from liquid chromatography-tandem mass spectrometry analysis of urine samples.
Toxicology letters.
2005 Dec; 159(3):235-51. doi:
10.1016/j.toxlet.2005.05.013. [PMID: 15996837] - Asa Bradman, Brenda Eskenazi, Dana B Barr, Roberto Bravo, Rosemary Castorina, Jonathan Chevrier, Katherine Kogut, Martha E Harnly, Thomas E McKone. Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community.
Environmental health perspectives.
2005 Dec; 113(12):1802-7. doi:
10.1289/ehp.7894. [PMID: 16330368] - Richard A Fenske, Asa Bradman, Robin M Whyatt, Mary S Wolff, Dana B Barr. Lessons learned for the assessment of children's pesticide exposure: critical sampling and analytical issues for future studies.
Environmental health perspectives.
2005 Oct; 113(10):1455-62. doi:
10.1289/ehp.7674. [PMID: 16203262] - Rogelio Recio, Guadalupe Ocampo-Gómez, Javier Morán-Martínez, Victor Borja-Aburto, Malaquías López-Cervante, Marisela Uribe, Luisa Torres-Sánchez, Mariano E Cebrián. Pesticide exposure alters follicle-stimulating hormone levels in Mexican agricultural workers.
Environmental health perspectives.
2005 Sep; 113(9):1160-3. doi:
10.1289/ehp.7374. [PMID: 16140621] - Wolfgang Bicker, Michael Lämmerhofer, Wolfgang Lindner. Determination of chlorpyrifos metabolites in human urine by reversed-phase/weak anion exchange liquid chromatography-electrospray ionisation-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Aug; 822(1-2):160-9. doi:
10.1016/j.jchromb.2005.06.003. [PMID: 15994139] - Larry L Needham. Assessing exposure to organophosphorus pesticides by biomonitoring in epidemiologic studies of birth outcomes.
Environmental health perspectives.
2005 Apr; 113(4):494-8. doi:
10.1289/ehp.7490. [PMID: 15811842] - William E Lambert, Michael Lasarev, Juan Muniz, Jennifer Scherer, Joan Rothlein, Juanita Santana, Linda McCauley. Variation in organophosphate pesticide metabolites in urine of children living in agricultural communities.
Environmental health perspectives.
2005 Apr; 113(4):504-8. doi:
10.1289/ehp.6890. [PMID: 15811843] - Jessica G Young, Brenda Eskenazi, Eleanor A Gladstone, Asa Bradman, Lesley Pedersen, Caroline Johnson, Dana B Barr, Clement E Furlong, Nina T Holland. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates.
Neurotoxicology.
2005 Mar; 26(2):199-209. doi:
10.1016/j.neuro.2004.10.004. [PMID: 15713341] - Brenda Eskenazi, Kim Harley, Asa Bradman, Erin Weltzien, Nicholas P Jewell, Dana B Barr, Clement E Furlong, Nina T Holland. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population.
Environmental health perspectives.
2004 Jul; 112(10):1116-24. doi:
10.1289/ehp.6789. [PMID: 15238287] - N Kupfermann, A Schmoldt, H Steinhart. Rapid and sensitive quantitative analysis of alkyl phosphates in urine after organophosphate poisoning.
Journal of analytical toxicology.
2004 May; 28(4):242-8. doi:
10.1093/jat/28.4.242. [PMID: 15189674] - Dana B Barr, Roberto Bravo, Gayanga Weerasekera, Lisa M Caltabiano, Ralph D Whitehead, Anders O Olsson, Samuel P Caudill, Susan E Schober, James L Pirkle, Eric J Sampson, Richard J Jackson, Larry L Needham. Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population.
Environmental health perspectives.
2004 Feb; 112(2):186-200. doi:
10.1289/ehp.6503. [PMID: 14754573] - Ursel Heudorf, Jürgen Angerer, Hans Drexler. Current internal exposure to pesticides in children and adolescents in Germany: urinary levels of metabolites of pyrethroid and organophosphorus insecticides.
International archives of occupational and environmental health.
2004 Jan; 77(1):67-72. doi:
10.1007/s00420-003-0470-5. [PMID: 14551781] - Asa Bradman, Dana B Barr, Birgit G Claus Henn, Timothy Drumheller, Cynthia Curry, Brenda Eskenazi. Measurement of pesticides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure: a validation study.
Environmental health perspectives.
2003 Nov; 111(14):1779-82. doi:
10.1289/ehp.6259. [PMID: 14594631] - S J Garfitt, K Jones, H J Mason, J Cocker. Exposure to the organophosphate diazinon: data from a human volunteer study with oral and dermal doses.
Toxicology letters.
2002 Aug; 134(1-3):105-13. doi:
10.1016/s0378-4274(02)00178-9. [PMID: 12191867] - Félix Hernández, Juan V Sancho, Oscar J Pozo. Direct determination of alkyl phosphates in human urine by liquid chromatography/electrospray tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2002; 16(18):1766-73. doi:
10.1002/rcm.790. [PMID: 12207365] - A N Oglobline, H Elimelakh, B Tattam, R Geyer, G E O'Donnell, G Holder. Negative ion chemical ionization GC/MS-MS analysis of dialkylphosphate metabolites of organophosphate pesticides in urine of non-occupationally exposed subjects.
The Analyst.
2001 Jul; 126(7):1037-41. doi:
10.1039/b102004h. [PMID: 11478632] - U Heudorf, J Angerer. Metabolites of organophosphorous insecticides in urine specimens from inhabitants of a residential area.
Environmental research.
2001 May; 86(1):80-7. doi:
10.1006/enrs.2001.4237. [PMID: 11386745] - R M Whyatt, D B Barr. Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study.
Environmental health perspectives.
2001 Apr; 109(4):417-20. doi:
10.1289/ehp.01109417. [PMID: 11335191] - L Balluz, D Moll, M G Diaz Martinez, J E Merida Colindres, J Malilay. Environmental pesticide exposure in Honduras following hurricane Mitch.
Bulletin of the World Health Organization.
2001; 79(4):288-95. doi:
NULL. [PMID: 11357206] - D Schenke. Analytical method for the determination of O,O-diethyl phosphate and O,O-diethyl thiophosphate in faecal samples.
Chemosphere.
2000 Nov; 41(9):1313-20. doi:
10.1016/s0045-6535(00)00020-5. [PMID: 11057566] - J Schole, C Schole, J Eikemeyer. Diethyl phosphate binding to mitochondrial cardiolipin after intraportal infusion in rats.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
1994 Sep; 49(9-10):657-64. doi:
10.1515/znc-1994-9-1017. [PMID: 7945677] - D M Lawson, A M Brzozowski, S Rety, C Verma, G G Dodson. Probing the nature of substrate binding in Humicola lanuginosa lipase through X-ray crystallography and intuitive modelling.
Protein engineering.
1994 Apr; 7(4):543-50. doi:
10.1093/protein/7.4.543. [PMID: 8029210] - K Takamiya. Monitoring of urinary alkyl phosphates in pest control operators exposed to various organophosphorus insecticides.
Bulletin of environmental contamination and toxicology.
1994 Feb; 52(2):190-5. doi:
10.1007/bf00198487. [PMID: 8123977] - Z Vasilić, V Drevenkar, B Stengl, Z Fröbe, V Rumenjak. Diethylphosphorus metabolites in serum and urine of persons poisoned by phosalone.
Chemico-biological interactions.
1993 Jun; 87(1-3):305-13. doi:
10.1016/0009-2797(93)90058-7. [PMID: 8343988] - V Drevenkar, Z Vasilić, B Stengl, Z Fröbe, V Rumenjak. Chlorpyrifos metabolites in serum and urine of poisoned persons.
Chemico-biological interactions.
1993 Jun; 87(1-3):315-22. doi:
10.1016/0009-2797(93)90059-8. [PMID: 7688273] - E D Richter, P Chuwers, Y Levy, M Gordon, F Grauer, J Marzouk, S Levy, S Barron, N Gruener. Health effects from exposure to organophosphate pesticides in workers and residents in Israel.
Israel journal of medical sciences.
1992 Aug; 28(8-9):584-98. doi:
NULL. [PMID: 1330977] - E D Richter, M Kowalski, A Leventhal, F Grauer, J Marzouk, S Brenner, I Shkolnik, S Lerman, H Zahavi, A Bashari. Illness and excretion of organophosphate metabolites four months after household pest extermination.
Archives of environmental health.
1992 Mar; 47(2):135-8. doi:
10.1080/00039896.1992.10118767. [PMID: 1567237] - R C Duncan, J Griffith. Monitoring study of urinary metabolites and selected symptomatology among Florida citrus workers.
Journal of toxicology and environmental health.
1985; 16(3-4):509-21. doi:
10.1080/15287398509530759. [PMID: 4087315] - J E Davies, V H Freed, H F Enos, R C Duncan, A Barquet, C Morgade, L J Peters, J X Danauskas. Reduction of pesticide exposure with protective clothing for applicators and mixers.
Journal of occupational medicine. : official publication of the Industrial Medical Association.
1982 Jun; 24(6):464-8. doi:
. [PMID: 7097378]
