Diethylphosphate (BioDeep_00000001668)

 

Secondary id: BioDeep_00001868072

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Volatile Flavor Compounds


代谢物信息卡片


Diethyl phosphate, chromium (+3) salt

化学式: C4H11O4P (154.0394936)
中文名称: 磷酸二乙酯
谱图信息: 最多检出来源 Homo sapiens(blood) 0.21%

Reviewed

Last reviewed on 2024-07-29.

Cite this Page

Diethylphosphate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/diethylphosphate (retrieved 2024-11-21) (BioDeep RN: BioDeep_00000001668). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCOP(=O)(O)OCC
InChI: InChI=1S/C4H11O4P/c1-3-7-9(5,6)8-4-2/h3-4H2,1-2H3,(H,5,6)

描述信息

Diethylphosphate is product of metabolism and of environmental degradation of Chlorpyrifos (CPF; a commonly used diethylphosphorothionate organophosphorus (OP) insecticide) and are routinely measured in urine as biomarkers of exposure. (PMID: 17590257). [HMDB]
Diethylphosphate is product of metabolism and of environmental degradation of Chlorpyrifos (CPF; a commonly used diethylphosphorothionate organophosphorus (OP) insecticide) and are routinely measured in urine as biomarkers of exposure. (PMID: 17590257).
KEIO_ID D141
Diethylphosphate (DEP) is product of metabolism and of environmental degradation of a commonly used insecticide Chlorpyrifos.

同义名列表

20 个代谢物同义名

Diethyl phosphate, chromium (+3) salt; Diethyl hydrogen phosphoric acid; Diethyl phosphate, sodium salt; O,O-Diethyl hydrogen phosphate; Phosphoric acid diethyl ester; Diethyl hydrogen phosphate; O,O-Diethylphosphoric acid; Diethyl phosphoric acid; diethoxyphosphinic acid; Diethyl acid phosphate; Diethylphosphoric acid; O,O-Diethyl phosphate; O,O-Diethylphosphate; Di-ethyl phosphate; Diethyl phosphate; Diethylphosphate; ethyl phosphate; DEP; DPF; Diethylphosphoric acid



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(5)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tamar Shamai Yamin, Moran Madmon, Ariel Hindi, Avital Shifrovich, Hagit Prihed, Merav Blanca, Avi Weissberg. Enhanced LC-ESI-MS/MS Sensitivity by Cationic Derivatization of Organophosphorus Acids. Molecules (Basel, Switzerland). 2023 Aug; 28(16):. doi: 10.3390/molecules28166090. [PMID: 37630342]
  • Fang-Wei Yang, Bing Fang, Guo-Fang Pang, Ming Zhang, Fa-Zheng Ren. Triazophos and its metabolite diethyl phosphate have different effects on endocrine hormones and gut health in rats. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2021; 56(6):566-576. doi: 10.1080/03601234.2021.1922042. [PMID: 34038317]
  • Fang-Wei Yang, Guo-Ping Zhao, Fa-Zheng Ren, Guo-Fang Pang, Yi-Xuan Li. Assessment of the endocrine-disrupting effects of diethyl phosphate, a nonspecific metabolite of organophosphorus pesticides, by in vivo and in silico approaches. Environment international. 2020 02; 135(?):105383. doi: 10.1016/j.envint.2019.105383. [PMID: 31835022]
  • Sukesh Narayan Sinha, Ungarala Venkat Ramakrishna, P K Sinha, C P Thakur. A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar-A comprehensive investigation on factors of toxicity. PloS one. 2020; 15(12):e0244798. doi: 10.1371/journal.pone.0244798. [PMID: 33382820]
  • Nayana K Jayatilaka, Paula Restrepo, Zachary Davis, Meghan Vidal, Antonia M Calafat, Maria Ospina. Quantification of 16 urinary biomarkers of exposure to flame retardants, plasticizers, and organophosphate insecticides for biomonitoring studies. Chemosphere. 2019 Nov; 235(?):481-491. doi: 10.1016/j.chemosphere.2019.06.181. [PMID: 31272008]
  • Antonio F Hernández, David Lozano-Paniagua, Beatriz González-Alzaga, Matthaios P Kavvalakis, Manolis N Tzatzarakis, Inmaculada López-Flores, Clemente Aguilar-Garduño, Rafael A Caparros-Gonzalez, Aristidis M Tsatsakis, Marina Lacasaña. Biomonitoring of common organophosphate metabolites in hair and urine of children from an agricultural community. Environment international. 2019 10; 131(?):104997. doi: 10.1016/j.envint.2019.104997. [PMID: 31362151]
  • Fangwei Yang, Jinwang Li, Guofang Pang, Fazheng Ren, Bing Fang. Effects of Diethyl Phosphate, a Non-Specific Metabolite of Organophosphorus Pesticides, on Serum Lipid, Hormones, Inflammation, and Gut Microbiota. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24102003. [PMID: 31137755]
  • Sukesh Narayan Sinha, Venkat Reddy Banda. Correlation of pesticide exposure from dietary intake and bio-monitoring: The different sex and socio-economic study of children. Ecotoxicology and environmental safety. 2018 10; 162(?):170-177. doi: 10.1016/j.ecoenv.2018.06.086. [PMID: 29990728]
  • Sunwook Kim, Maury A Nussbaum, Paul J Laurienti, Haiying Chen, Sara A Quandt, Dana Boyd Barr, Thomas A Arcury. Exploring Associations Between Postural Balance and Levels of Urinary Organophosphorus Pesticide Metabolites. Journal of occupational and environmental medicine. 2018 02; 60(2):174-179. doi: 10.1097/jom.0000000000001194. [PMID: 29023345]
  • Yiwen Wang, Yan Zhang, Lin Ji, Yi Hu, Jingjing Zhang, Caifeng Wang, Guodong Ding, Limei Chen, Michihiro Kamijima, Jun Ueyama, Yu Gao, Ying Tian. Prenatal and postnatal exposure to organophosphate pesticides and childhood neurodevelopment in Shandong, China. Environment international. 2017 11; 108(?):119-126. doi: 10.1016/j.envint.2017.08.010. [PMID: 28843140]
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  • Lesliam Quirós-Alcalá, Asa Bradman, Kimberly Smith, Gayanga Weerasekera, Martins Odetokun, Dana Boyd Barr, Marcia Nishioka, Rosemary Castorina, Alan E Hubbard, Mark Nicas, S Katharine Hammond, Thomas E McKone, Brenda Eskenazi. Organophosphorous pesticide breakdown products in house dust and children's urine. Journal of exposure science & environmental epidemiology. 2012 Nov; 22(6):559-68. doi: 10.1038/jes.2012.46. [PMID: 22781438]
  • Pei Wang, Ying Tian, Xiao-Jin Wang, Yu Gao, Rong Shi, Guo-Quan Wang, Guo-Hua Hu, Xiao-Ming Shen. Organophosphate pesticide exposure and perinatal outcomes in Shanghai, China. Environment international. 2012 Jul; 42(?):100-4. doi: 10.1016/j.envint.2011.04.015. [PMID: 21601922]
  • Jun Ueyama, Isao Saito, Takaaki Kondo, Tomoko Taki, Akiko Kimata, Shun Saito, Yuki Ito, Katsuyuki Murata, Toyoto Iwata, Masahiro Gotoh, Eiji Shibata, Shinya Wakusawa, Michihiro Kamijima. Urinary concentrations of organophosphorus insecticide metabolites in Japanese workers. Chemosphere. 2012 Jun; 87(11):1403-9. doi: 10.1016/j.chemosphere.2012.02.048. [PMID: 22455950]
  • Matthaios P Kavvalakis, Aristidis M Tsatsakis. The atlas of dialkylphosphates; assessment of cumulative human organophosphorus pesticides' exposure. Forensic science international. 2012 May; 218(1-3):111-22. doi: 10.1016/j.forsciint.2011.10.019. [PMID: 22018851]
  • Alison L Clune, P Barry Ryan, Dana Boyd Barr. Have regulatory efforts to reduce organophosphorus insecticide exposures been effective?. Environmental health perspectives. 2012 Apr; 120(4):521-5. doi: 10.1289/ehp.1104323. [PMID: 22251442]
  • Toshiaki Yoshida, Jin Yoshida. Simultaneous analytical method for urinary metabolites of organophosphorus compounds and moth repellents in general population. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jan; 880(1):66-73. doi: 10.1016/j.jchromb.2011.11.018. [PMID: 22130501]
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  • Xiao-Fei Tian, Zhen Fang, Dan Jiang, Xi-Yan Sun. Pretreatment of microcrystalline cellulose in organic electrolyte solutions for enzymatic hydrolysis. Biotechnology for biofuels. 2011 Nov; 4(1):53. doi: 10.1186/1754-6834-4-53. [PMID: 22099703]
  • Yoshikazu Arai, Jun Ohgane, Shintaro Yagi, Rie Ito, Yusuke Iwasaki, Koichi Saito, Kazuhiko Akutsu, Satoshi Takatori, Rie Ishii, Rumiko Hayashi, Shun-Ichiro Izumi, Norihiro Sugino, Fumio Kondo, Masakazu Horie, Hiroyuki Nakazawa, Tsunehisa Makino, Kunio Shiota. Epigenetic assessment of environmental chemicals detected in maternal peripheral and cord blood samples. The Journal of reproduction and development. 2011 Sep; 57(4):507-17. doi: 10.1262/jrd.11-034a. [PMID: 21606628]
  • Dana Boyd Barr, Lee-Yang Wong, Roberto Bravo, Gayanga Weerasekera, Martins Odetokun, Paula Restrepo, Do-Gyun Kim, Carolina Fernandez, Ralph D Whitehead, Jose Perez, Maribel Gallegos, Bryan L Williams, Larry L Needham. Urinary concentrations of dialkylphosphate metabolites of organophosphorus pesticides: National Health and Nutrition Examination Survey 1999-2004. International journal of environmental research and public health. 2011 08; 8(8):3063-98. doi: 10.3390/ijerph8083063. [PMID: 21909292]
  • Maryse F Bouchard, Jonathan Chevrier, Kim G Harley, Katherine Kogut, Michelle Vedar, Norma Calderon, Celina Trujillo, Caroline Johnson, Asa Bradman, Dana Boyd Barr, Brenda Eskenazi. Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environmental health perspectives. 2011 Aug; 119(8):1189-95. doi: 10.1289/ehp.1003185. [PMID: 21507776]
  • Stephanie M Engel, James Wetmur, Jia Chen, Chenbo Zhu, Dana Boyd Barr, Richard L Canfield, Mary S Wolff. Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environmental health perspectives. 2011 Aug; 119(8):1182-8. doi: 10.1289/ehp.1003183. [PMID: 21507778]
  • Asa Bradman, Rosemary Castorina, Dana Boyd Barr, Jonathan Chevrier, Martha E Harnly, Ellen A Eisen, Thomas E McKone, Kim Harley, Nina Holland, Brenda Eskenazi. Determinants of organophosphorus pesticide urinary metabolite levels in young children living in an agricultural community. International journal of environmental research and public health. 2011 04; 8(4):1061-83. doi: 10.3390/ijerph8041061. [PMID: 21695029]
  • Pornpimol Kongtip, Sirinnapa Changfuang, Witaya Yoosook, Suttinun Chantanakul, Dusit Sujirarat. Ethion exposure and biological monitoring in vegetable farmers. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2011 Mar; 94(3):286-94. doi: . [PMID: 21560835]
  • Yan Zhang, Sha Zhu, Yu Gao, Xiao-jin Wang, Tao Chen, You Yang, Guo-quan Wang, Guo-hua Hu, Rong Shi, Ping Jin, Ying Tian. [A case-control study on correlation of pesticide exposure with childhood acute leukemia]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2011 Jan; 45(1):41-6. doi: . [PMID: 21418818]
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  • Brenda Eskenazi, Karen Huen, Amy Marks, Kim G Harley, Asa Bradman, Dana Boyd Barr, Nina Holland. PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero. Environmental health perspectives. 2010 Dec; 118(12):1775-81. doi: 10.1289/ehp.1002234. [PMID: 21126941]
  • Amy R Marks, Kim Harley, Asa Bradman, Katherine Kogut, Dana Boyd Barr, Caroline Johnson, Norma Calderon, Brenda Eskenazi. Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study. Environmental health perspectives. 2010 Dec; 118(12):1768-74. doi: 10.1289/ehp.1002056. [PMID: 21126939]
  • Martins S Odetokun, M Angela Montesano, Gayanga Weerasekera, Ralph D Whitehead, Larry L Needham, Dana Boyd Barr. Quantification of dialkylphosphate metabolites of organophosphorus insecticides in human urine using 96-well plate sample preparation and high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Oct; 878(27):2567-74. doi: 10.1016/j.jchromb.2010.04.027. [PMID: 20494630]
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