hexestrol (BioDeep_00000016480)

   


代谢物信息卡片


4,4-(1,2-Diethylethylene)Diphenol

化学式: C18H22O2 (270.1619712)
中文名称: 己烷雌酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C1=CC=C(C=C1)O)C(CC)C2=CC=C(C=C2)O
InChI: InChI=1S/C18H22O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,17-20H,3-4H2,1-2H3

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
D000970 - Antineoplastic Agents
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4806; ORIGINAL_PRECURSOR_SCAN_NO 4804
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4817; ORIGINAL_PRECURSOR_SCAN_NO 4815
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4774; ORIGINAL_PRECURSOR_SCAN_NO 4772
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4796; ORIGINAL_PRECURSOR_SCAN_NO 4794
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4834; ORIGINAL_PRECURSOR_SCAN_NO 4832
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4799; ORIGINAL_PRECURSOR_SCAN_NO 4795
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8887; ORIGINAL_PRECURSOR_SCAN_NO 8882
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8903; ORIGINAL_PRECURSOR_SCAN_NO 8901
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8923; ORIGINAL_PRECURSOR_SCAN_NO 8921
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8953; ORIGINAL_PRECURSOR_SCAN_NO 8951
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8970; ORIGINAL_PRECURSOR_SCAN_NO 8969
CONFIDENCE standard compound; INTERNAL_ID 826; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8944; ORIGINAL_PRECURSOR_SCAN_NO 8942

同义名列表

3 个代谢物同义名

4,4-(1,2-Diethylethylene)Diphenol; hexestrol; meso-Hexestrol



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ovokeroye Akpojevwe Abafe, Pumza M Gatyeni, Tlou Chokwe. Development and validation of a confirmatory method for the determination of stilbene estrogens in ostrich serum. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2018 Mar; 35(3):458-466. doi: 10.1080/19440049.2017.1411617. [PMID: 29210606]
  • Mosotho J George, Ljiljana Marjanovic, D Bradley G Williams. Picogram-level quantification of some growth hormones in bovine urine using mixed-solvent bubble-in-drop single drop micro-extraction. Talanta. 2015 Nov; 144(?):445-50. doi: 10.1016/j.talanta.2015.06.070. [PMID: 26452846]
  • Iraida G Syasina, Nikita A Shved. Hexestrol- and nonylphenol-induced differential vitellogenin synthesis in female and male barfin plaice Liopsetta pinnifasciata. Environmental toxicology and pharmacology. 2015 Mar; 39(2):597-605. doi: 10.1016/j.etap.2015.01.014. [PMID: 25682006]
  • Huixiao Hong, William S Branham, Stacey L Dial, Carrie L Moland, Hong Fang, Jie Shen, Roger Perkins, Daniel Sheehan, Weida Tong. Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities. Chemical research in toxicology. 2012 Nov; 25(11):2553-66. doi: 10.1021/tx3003406. [PMID: 23013281]
  • Shuyu Nong, Fuhua Lin, Xiaojia Huang, Dongxing Yuan. Preparation of a stir bar sorptive extraction coating based on molecularly imprinted polymer and its application in the extraction of dienestrol and hexestrol in complicated samples. Se pu = Chinese journal of chromatography. 2012 Nov; 30(11):1133-42. doi: 10.3724/sp.j.1123.2012.08034. [PMID: 23451515]
  • Qisheng Zhong, Yufei Hu, Yuling Hu, Gongke Li. Dynamic liquid-liquid-solid microextraction based on molecularly imprinted polymer filaments on-line coupling to high performance liquid chromatography for direct analysis of estrogens in complex samples. Journal of chromatography. A. 2012 Jun; 1241(?):13-20. doi: 10.1016/j.chroma.2012.04.017. [PMID: 22554413]
  • Karol L Thompson, Kylie Haskins, Barry A Rosenzweig, Sharron Stewart, Jun Zhang, David Peters, Alan Knapton, Rodney Rouse, Daniel Mans, Thomas Colatsky. Comparison of the diagnostic accuracy of di-22:6-bis(monoacylglycerol)phosphate and other urinary phospholipids for drug-induced phospholipidosis or tissue injury in the rat. International journal of toxicology. 2012 Jan; 31(1):14-24. doi: 10.1177/1091581811430167. [PMID: 22267869]
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  • Mireia Urpi-Sarda, Raul Zamora-Ros, Rosa Lamuela-Raventos, Antonio Cherubini, Olga Jauregui, Rafael de la Torre, Maria Isabel Covas, Ramon Estruch, Walter Jaeger, Cristina Andres-Lacueva. HPLC-tandem mass spectrometric method to characterize resveratrol metabolism in humans. Clinical chemistry. 2007 Feb; 53(2):292-9. doi: 10.1373/clinchem.2006.071936. [PMID: 17170057]
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  • ChuanLai Xu, ChiFang Peng, Liqiang Liu, Liying Wang, ZhengYu Jin, XiaoGang Chu. Determination of hexoestrol residues in animal tissues based on enzyme-linked immunosorbent assay and comparison with liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2006 Jun; 41(3):1029-36. doi: 10.1016/j.jpba.2006.01.016. [PMID: 16497468]
  • Shuhei Ishikura, Kengo Matsumoto, Masaharu Sanai, Kenji Horie, Toshiyuki Matsunaga, Kazuo Tajima, Ossama El-Kabbani, Akira Hara. Molecular cloning of a novel type of rat cytoplasmic 17beta-hydroxysteroid dehydrogenase distinct from the type 5 isozyme. Journal of biochemistry. 2006 Jun; 139(6):1053-63. doi: 10.1093/jb/mvj109. [PMID: 16788056]
  • Muhammad Saeed, Sandra J Gunselman, Sheila Higginbotham, Eleanor Rogan, Ercole Cavalieri. Formation of the depurinating N3adenine and N7guanine adducts by reaction of DNA with hexestrol-3',4'-quinone or enzyme-activated 3'-hydroxyhexestrol. Implications for a unifying mechanism of tumor initiation by natural and synthetic estrogens. Steroids. 2005 Jan; 70(1):37-45. doi: 10.1016/j.steroids.2004.09.012. [PMID: 15610895]
  • Leslie C Dickson, James D MacNeil, JoAnn Reid, Adrian C E Fesser. Validation of screening method for residues of diethylstilbestrol, dienestrol, hexestrol, and zeranol in bovine urine using immunoaffinity chromatography and gas chromatography/mass spectrometry. Journal of AOAC International. 2003 Jul; 86(4):631-9. doi: . [PMID: 14509418]
  • R Todd Stravitz, Arun J Sanyal. Drug-induced steatohepatitis. Clinics in liver disease. 2003 May; 7(2):435-51. doi: 10.1016/s1089-3261(03)00027-8. [PMID: 12879993]
  • Yuliya Dobrydneva, Roy L Williams, John A Katzenellenbogen, Paul H Ratz, Peter F Blackmore. Diethylstilbestrol and tetrahydrochrysenes are calcium channel blockers in human platelets: relationship to the stilbene pharmacophore. Thrombosis research. 2003 Apr; 110(1):23-31. doi: 10.1016/s0049-3848(03)00110-5. [PMID: 12877905]
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  • A Berson, V De Beco, P Lettéron, M A Robin, C Moreau, J El Kahwaji, N Verthier, G Feldmann, B Fromenty, D Pessayre. Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology. 1998 Apr; 114(4):764-74. doi: 10.1016/s0016-5085(98)70590-6. [PMID: 9516397]
  • G G Kuiper, B Carlsson, K Grandien, E Enmark, J Häggblad, S Nilsson, J A Gustafsson. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 1997 Mar; 138(3):863-70. doi: 10.1210/endo.138.3.4979. [PMID: 9048584]
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  • F van Bambeke, M P Mingeot-Leclercq, R Brasseur, P M Tulkens, A Schanck. Aminoglycoside antibiotics prevent the formation of non-bilayer structures in negatively-charged membranes. Comparative studies using fusogenic (bis(beta-diethylaminoethylether)hexestrol) and aggregating (spermine) agents. Chemistry and physics of lipids. 1996 Mar; 79(2):123-35. doi: 10.1016/0009-3084(95)02520-0. [PMID: 8640900]
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