Strychnine (BioDeep_00000001646)

   

natural product Chemicals and Drugs


代谢物信息卡片


(4aR,5aS,8aR,13aS,15aS,15bR)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one

化学式: C21H22N2O2 (334.1681192)
中文名称: 番木鳖碱, 士的宁
谱图信息: 最多检出来源 Viridiplantae(plant) 1.9%

分子结构信息

SMILES: c(c7)cc(c(c7)1)N(C(=O)6)C([H])(C([H])45)C(C2)1C(C3)N(CC(=CCOC([H])(C6)5)C34)C2
InChI: InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2

描述信息

Strychnine (/ˈstrɪkniːn, -nɪn/, STRIK-neen, -⁠nin, US chiefly /-naɪn/ -⁠nyne)[6][7] is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the eyes or mouth, causes poisoning which results in muscular convulsions and eventually death through asphyxia.[8] While it is no longer used medicinally, it was used historically in small doses to strengthen muscle contractions, such as a heart and bowel stimulant[9] and performance-enhancing drug. The most common source is from the seeds of the Strychnos nux-vomica tree.

Strychnine is a natural product found in Strychnos ignatii, Strychnos wallichiana

D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.
D018377 - Neurotransmitter Agents > D018684 - Glycine Agents
D009676 - Noxae > D011042 - Poisons
Annotation level-1
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.465
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.456
CONFIDENCE standard compound; INTERNAL_ID 694; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5745; ORIGINAL_PRECURSOR_SCAN_NO 5743
CONFIDENCE standard compound; INTERNAL_ID 694; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5769; ORIGINAL_PRECURSOR_SCAN_NO 5767
CONFIDENCE standard compound; INTERNAL_ID 694; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5764; ORIGINAL_PRECURSOR_SCAN_NO 5762
CONFIDENCE standard compound; INTERNAL_ID 694; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5713; ORIGINAL_PRECURSOR_SCAN_NO 5712
CONFIDENCE standard compound; INTERNAL_ID 694; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5746; ORIGINAL_PRECURSOR_SCAN_NO 5745
CONFIDENCE standard compound; INTERNAL_ID 694; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5749; ORIGINAL_PRECURSOR_SCAN_NO 5746
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2322

同义名列表

3 个代谢物同义名

Strychnine; Strychnidin-10-one; (-)-Strychnine



数据库引用编号

81 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Uswatun Khasanah, Queen Intan Nurrahmah, Thia Amalia, Zada Nabila Putri, Imrokatul Mufidah, Roisatun Napik, Diana Lyrawati, Bachtiar Rifai Pratita Ihsan, Maya Eka Febrianti. Oral acute toxicity study and in vivo antimalarial activity of Strychnos lucida R. Br. tablet. Journal of ethnopharmacology. 2024 Aug; 330(?):118200. doi: 10.1016/j.jep.2024.118200. [PMID: 38621467]
  • Yong Yang, Peng Li, Xiaojia Li, Ying Zhu, Xiutian Guo. Brucine D restrains colorectal cancer tumorigenesis and autophagy by downregulating circ_0068464. Chemical biology & drug design. 2024 Jan; 103(1):e14407. doi: 10.1111/cbdd.14407. [PMID: 38040413]
  • Weiran Liu, Xintian Tang, Chengyu Fan, Guannan He, Xiaoxin Wang, Xiaodong Liang, Xia Bao. Chemical constituents, pharmacological action, antitumor application, and toxicity of Strychnine Semen from Strychnons pierriana A.W.Hill.: A review. Journal of ethnopharmacology. 2023 Jun; ?(?):116748. doi: 10.1016/j.jep.2023.116748. [PMID: 37348797]
  • Cletus Anes Ukwubile, Emmanuel Oise Ikpefan, Musa Yusuf Dibal, Vivian Amarachukwu Umeano, David Nnamdi Menkiti, Clement Chidi Kaosi, Simon Paul, Ademola Clement Famurewa, Henry Nettey, Timothy Samuel Yerima. Pharmacognostic profiles, evaluation of analgesic, anti-inflammatory and anticonvulsant activities of Newbouldia laevis (P. Beauv.) Seem. ex Bureau leaf and root extracts in Wistar rats. Journal of ethnopharmacology. 2023 May; 314(?):116632. doi: 10.1016/j.jep.2023.116632. [PMID: 37211190]
  • Maxwell Blesdel Adassi, Gwladys Temkou Ngoupaye, Francis Bray Yassi, Aurelien Fossueh Foutsop, Tatiana Diebo Kom, Elisabeth Ngo Bum. Revealing the most effective anticonvulsant part of Malvaviscus arboreus Dill. Ex Cav. and its acute and sub-acute toxicity. Journal of ethnopharmacology. 2023 Mar; 303(?):115995. doi: 10.1016/j.jep.2022.115995. [PMID: 36509255]
  • Yan Gao, Lin Guo, Ying Han, Jingpu Zhang, Zhong Dai, Shuangcheng Ma. A Combination of In Silico ADMET Prediction, In Vivo Toxicity Evaluation, and Potential Mechanism Exploration of Brucine and Brucine N-oxide-A Comparative Study. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28031341. [PMID: 36771007]
  • Akram Hegazy, Sara H Mahmoud, Yaseen A M M Elshaier, Noura M Abo Shama, Nasr Fawzy Nasr, M A Ali, Assem Mohamed El-Shazly, Islam Mostafa, Ahmed Mostafa. Antiviral activities of plant-derived indole and β-carboline alkaloids against human and avian influenza viruses. Scientific reports. 2023 Jan; 13(1):1612. doi: 10.1038/s41598-023-27954-0. [PMID: 36709362]
  • Yuyan Guo, Zejun Meng, Yuanyuan Gu, Weinan Li, Shuang Sun, Qiuhong Wang, Haixue Kuang. HPLC-MS/MS analysis of primary alkaloids in rat plasma after oral administration of "Nux vomica - Glycyrrhiza glabra decoction": A pharmacokinetic study. Journal of ethnopharmacology. 2022 Nov; 298(?):115588. doi: 10.1016/j.jep.2022.115588. [PMID: 35931305]
  • Sanath K Kandy, Jonathan R Chekan. Biosynthesis of the Plant-Produced Toxin Strychnine Elucidated. Angewandte Chemie (International ed. in English). 2022 11; 61(45):e202212301. doi: 10.1002/anie.202212301. [PMID: 36125917]
  • Jialin Dai, Jiangjin Liu, Maoxin Zhang, Yanni Yu, Jie Wang. Network toxicology and molecular docking analyses on strychnine indicate CHRM1 is a potential neurotoxic target. BMC complementary medicine and therapies. 2022 Oct; 22(1):273. doi: 10.1186/s12906-022-03753-4. [PMID: 36244968]
  • Yan Chen, Pei-Chao Wang, Shuai-Shuai Zhang, Jun Yang, Guo-Cheng Li, Ling-Qiao Huang, Chen-Zhu Wang. Functional analysis of a bitter gustatory receptor highly expressed in the larval maxillary galea of Helicoverpa armigera. PLoS genetics. 2022 10; 18(10):e1010455. doi: 10.1371/journal.pgen.1010455. [PMID: 36206313]
  • Weixiu Xu, Lijie Wu, Shenhui Liu, Xiao Liu, Xiaoling Cao, Cui Zhou, Jinyi Zhang, You Fu, Yu Guo, Yiran Wu, Qiwen Tan, Ling Wang, Junlin Liu, Longquan Jiang, Zhongbo Fan, Yuan Pei, Jingyi Yu, Jianjun Cheng, Suwen Zhao, Xiaojiang Hao, Zhi-Jie Liu, Tian Hua. Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science (New York, N.Y.). 2022 09; 377(6612):1298-1304. doi: 10.1126/science.abo1633. [PMID: 36108005]
  • Olivier Bonnet, Mehdi A Beniddir, Pierre Champy, Védaste Kagisha, Alain Nyirimigabo, Carla Hamann, Giorgi Jgerenaia, Allison Ledoux, Alembert Tiabou Tchinda, Luc Angenot, Michel Frédérich. Exploration by molecular networking of Strychnos alkaloids reveals the unexpected occurrence of strychnine in seven Strychnos species. Toxicon : official journal of the International Society on Toxinology. 2022 Aug; 215(?):57-68. doi: 10.1016/j.toxicon.2022.06.002. [PMID: 35690276]
  • Sara A Al-Sayed, Mohamed O Amin, Entesar Al-Hetlani. SALDI Substrate-Based FeNi Magnetic Alloy Nanoparticles for Forensic Analysis of Poisons in Human Serum. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092720. [PMID: 35566070]
  • Yuan Jiang, Lin Qin, Anjing Lu, Juan Chen, Jianmei Wang, Qianru Zhang, Yanliu Lu, Qihai Gong, Jianmei Gao, Hong Ma, Daopeng Tan, Yuqi He. CYP3A1 metabolism-based neurotoxicity of strychnine in rat. Toxicology. 2022 Mar; 471(?):153156. doi: 10.1016/j.tox.2022.153156. [PMID: 35358606]
  • Bakhtiyar Qader, Issam Hussain, Mark Baron, Rafael Estevez-Brito, John Paul Cassella, Jose Gonzalez-Rodriguez. The Production and Evaluation of an Electrochemical Sensors for Strychnine and Its Main Metabolite Strychnine N-Oxide for Their Use in Biological Samples. Molecules (Basel, Switzerland). 2022 Mar; 27(6):. doi: 10.3390/molecules27061826. [PMID: 35335189]
  • Li-Li Liu, Xie-Xie Chen, Yu-Ting Yin, Hui-Fa Ouyang, Yong-Mei Guan, Wei-Feng Zhu, Li-Hua Chen. [Pharmacokinetic behavior and brain tissue distribution of paeoniflorin combined with normal and toxic doses of strychnine in rats after percutaneous administration]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Feb; 47(4):1064-1072. doi: 10.19540/j.cnki.cjcmm.20211102.202. [PMID: 35285207]
  • Tabbassum Zehra, Sana Sarfaraz, Rahela Ikram. Dose dependent anticonvulsant activity of Morus nigra in strychnine induced seizures model. Pakistan journal of pharmaceutical sciences. 2021 Nov; 34(6):2167-2171. doi: ". [PMID: 35034877]
  • Shan Lu, Xuan-Zhong Wang, Chuan He, Lei Wang, Shi-Peng Liang, Chong-Cheng Wang, Chen Li, Tian-Fei Luo, Chun-Sheng Feng, Zhen-Chuan Wang, Guang-Fan Chi, Peng-Fei Ge. ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron. Acta pharmacologica Sinica. 2021 Oct; 42(10):1690-1702. doi: 10.1038/s41401-021-00700-w. [PMID: 34112960]
  • Bin Liu, Yuqing Zhang, Qingke Wu, Li Wang, Bo Hu. Alleviation of isoprenaline hydrochloride induced myocardial ischemia injury by brucine through the inhibition of Na+/K+-ATPase. Experimental gerontology. 2021 07; 149(?):111332. doi: 10.1016/j.exger.2021.111332. [PMID: 33781843]
  • Aliance Romain Fokoua, Magloire K Ndjenda, Adeline Kaptué Wuyt, Francis Desire Tatsinkou Bomba, Appolinaire Kene Dongmo, Rodolphe Chouna, Pepin Alango Nkeng-Efouet, Télesphore Benoît Nguelefack. Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats. Journal of ethnopharmacology. 2021 May; 272(?):113955. doi: 10.1016/j.jep.2021.113955. [PMID: 33610704]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Lu Gao, Yanke Lin, Shuai Wang, Luomin Lin, Danyi Lu, Yue Zhao, Huijie Xing, Baojian Wu. Chronotoxicity of Semen Strychni is associated with circadian metabolism and transport in mice. The Journal of pharmacy and pharmacology. 2021 Mar; 73(3):398-409. doi: 10.1093/jpp/rgaa007. [PMID: 33793874]
  • Ernest Obese, Robert Peter Biney, Isaac Tabiri Henneh, Emmanuel Awintiig Adakudugu, Daniel Anokwah, Lovia Serwaa Agyemang, Eric Woode, Elvis Ofori Ameyaw. The Anticonvulsant Effect of Hydroethanolic Leaf Extract of Calotropis procera (Ait) R. Br. (Apocynaceae). Neural plasticity. 2021; 2021(?):5566890. doi: 10.1155/2021/5566890. [PMID: 34257639]
  • Hok-Fung Tong, Candace Yim Chan, Sau-Wah Ng, Tony Wing-Lai Mak. Strychnine poisoning due to traditional Chinese medicine: a case series. F1000Research. 2021 ; 10(?):924. doi: 10.12688/f1000research.73072.2. [PMID: 35169461]
  • Heba S Elsewedy, Bandar E Al Dhubiab, Mahmoud A Mahdy, Hanan M Elnahas. Development, optimization, and evaluation of PEGylated brucine-loaded PLGA nanoparticles. Drug delivery. 2020 Dec; 27(1):1134-1146. doi: 10.1080/10717544.2020.1797237. [PMID: 32729331]
  • Min Zhang, Chao Wang, Zheng-Lin Ou, Jing Wen, Hua-Lin Cai, Ping-Fei Fang. Effects of licorice extracts on the pharmacokinetics of brucine in rats and its possible mechanism. Pakistan journal of pharmaceutical sciences. 2020 Sep; 33(5):1995-2002. doi: . [PMID: 33824106]
  • Dan Lü, Qieying Jiang, Jing Zhang, Ronggui Zeng, Zhenggen Liao, Xinli Liang. Effect of Baizhu (Rhizoma Atractylodis Macrocephalae) extract on intestinal absorption of brucine and strychnine in vitro and in situ. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2020 08; 40(4):562-570. doi: 10.19852/j.cnki.jtcm.2020.04.005. [PMID: 32744023]
  • Nestor Ishimwe, Pengfei Wei, Meimei Wang, Hao Zhang, Liansheng Wang, Manman Jing, Longping Wen, Yunjiao Zhang. Autophagy Impairment through Lysosome Dysfunction by Brucine Induces Immunogenic Cell Death (ICD). The American journal of Chinese medicine. 2020; 48(8):1915-1940. doi: 10.1142/s0192415x20500962. [PMID: 33308096]
  • Min Zhang, Chao Wang, Hua-Lin Cai, Jing Wen, Ping-Fei Fang. Licorice Extracts Attenuate Nephrotoxicity Induced by Brucine Through Suppression of Mitochondria Apoptotic Pathway and STAT3 Activation. Current medical science. 2019 Dec; 39(6):890-898. doi: 10.1007/s11596-019-2126-z. [PMID: 31845219]
  • Ziyue Zhou, Yanke Lin, Lu Gao, Zemin Yang, Shuai Wang, Baojian Wu. Cyp3a11 metabolism-based chronotoxicity of brucine in mice. Toxicology letters. 2019 Oct; 313(?):188-195. doi: 10.1016/j.toxlet.2019.07.007. [PMID: 31284022]
  • Sidra Maqbool, Ishrat Younus, Rafia Sadaf, Anab Fatima. Neuro-pharmacological evaluation of anticonvulsant and neuroprotective activity of Cocculus laurifolius leaves in wistar rats. Metabolic brain disease. 2019 08; 34(4):991-999. doi: 10.1007/s11011-019-00414-3. [PMID: 30993565]
  • Hua Ren, Jianping Zhao, Dongsheng Fan, Ze Wang, Tingjie Zhao, Yuejin Li, Yirui Zhao, David Adelson, Huiqin Hao. Alkaloids from nux vomica suppresses colon cancer cell growth through Wnt/β-catenin signaling pathway. Phytotherapy research : PTR. 2019 May; 33(5):1570-1578. doi: 10.1002/ptr.6347. [PMID: 30907037]
  • Moon Hee Hur, Vinod Havalad, Christopher Clardy. Strychnine: Old Remedy, Silent Killer. Pediatric annals. 2019 May; 48(5):e205-e207. doi: 10.3928/19382359-20190422-04. [PMID: 31067337]
  • Guang Yu, Linnan Qian, Juanjuan Yu, Min Tang, Changming Wang, Yuan Zhou, Xiao Geng, Chan Zhu, Yan Yang, Yang Pan, Xu Shen, Zongxiang Tang. Brucine alleviates neuropathic pain in mice via reducing the current of the sodium channel. Journal of ethnopharmacology. 2019 Apr; 233(?):56-63. doi: 10.1016/j.jep.2018.12.045. [PMID: 30599222]
  • Meng-Ran Xu, Peng-Fei Wei, Ming-Zhu Suo, Yi Hu, Weiping Ding, Li Su, Yao-Dong Zhu, Wan-Ji Song, Guan-Hao Tang, Mei Zhang, Ping Li. Brucine Suppresses Vasculogenic Mimicry in Human Triple-Negative Breast Cancer Cell Line MDA-MB-231. BioMed research international. 2019; 2019(?):6543230. doi: 10.1155/2019/6543230. [PMID: 30723742]
  • Uma Saminathan, Pachaiappan Pugalendhi, Suganthi Subramaniyan, Rajendran Jayaganesh. Biochemical studies evaluating the chemopreventive potential of brucine in chemically induced mammary carcinogenesis of rats. Toxicology mechanisms and methods. 2019 Jan; 29(1):8-17. doi: 10.1080/15376516.2018.1502387. [PMID: 30027798]
  • Chunhua Yuan, Zhengyi Luo, Ying Zhou, Sheng Lei, Changxi Xu, Chao Peng, Shuji Li, Xiaowen Li, Xinhong Zhu, Tianming Gao. Removal of hERG potassium channel affinity through introduction of an oxygen atom: Molecular insights from structure-activity relationships of strychnine and its analogs. Toxicology and applied pharmacology. 2018 12; 360(?):109-119. doi: 10.1016/j.taap.2018.09.042. [PMID: 30282042]
  • Jian-Bo Ma, Hai-Wen Qiu, Qiu-Hong Rui, Yu-Feng Liao, Yan-Min Chen, Jin Xu, Yun Zhang, Yan Zhu, Yong-Gang Zhao. Enhanced cleanup efficiency hydroxy functionalized-magnetic graphene oxide and its comparison with magnetic carboxyl-graphene for PRiME pass-through cleanup of strychnine and brucine in human plasma samples. Analytica chimica acta. 2018 Aug; 1020(?):41-50. doi: 10.1016/j.aca.2018.03.008. [PMID: 29655427]
  • Tiankun Ren, Menglin Li, Hao Zheng, Wenwei Liu, Jinlan Zhang. Microdialysis combined with RRLC-MS/MS for the pharmacokinetics of two major alkaloids of Bi qi capsule and the potential roles of P-gp and BCRP on their penetration. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Aug; 1092(?):72-81. doi: 10.1016/j.jchromb.2018.05.048. [PMID: 29883892]
  • Xianpeng Shi, Man Zhu, Yuan Kang, Tianfeng Yang, Xia Chen, Yanmin Zhang. Wnt/β-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jul; 46(?):85-92. doi: 10.1016/j.phymed.2018.04.019. [PMID: 30097126]
  • Shujuan Li, Yanjie Chu, Ruowen Zhang, Linjia Sun, Xiaohui Chen. Prophylactic Neuroprotection of Total Glucosides of Paeoniae Radix Alba against Semen Strychni-Induced Neurotoxicity in Rats: Suppressing Oxidative Stress and Reducing the Absorption of Toxic Components. Nutrients. 2018 Apr; 10(4):. doi: 10.3390/nu10040514. [PMID: 29677121]
  • Hao Zheng, Zhe Wang, Wenwei Liu, Hongtao Jin, Jinlan Zhang. Toxicokinetics of strychnine and brucine after the oral administration of Biqi capsule to rats by RRLC-MS/MS. Biomedical chromatography : BMC. 2018 Mar; 32(3):. doi: 10.1002/bmc.4117. [PMID: 29027676]
  • Min Zhang, Yang Deng, Chao Wang, Hua-Lin Cai, Jing Wen, Ping-Fei Fang, Bi-Kui Zhang, Huan-De Li, Miao Yan. An LC-MS/MS method for determination of bioactive components of liquorice and Semen Strychni in rat plasma: Application to a pharmacokinetics study. Drug testing and analysis. 2018 Feb; 10(2):262-271. doi: 10.1002/dta.2210. [PMID: 28447397]
  • Rixin Guo, Ting Wang, Guohong Zhou, Mengying Xu, Xiankuo Yu, Xiao Zhang, Feng Sui, Chun Li, Liying Tang, Zhuju Wang. Botany, Phytochemistry, Pharmacology and Toxicity of Strychnos nux-vomica L.: A Review. The American journal of Chinese medicine. 2018; 46(1):1-23. doi: 10.1142/s0192415x18500015. [PMID: 29298518]
  • Taiyi Wang, Xiaonan Chen, Jiahui Yu, Qunqun Du, Jie Zhu, Mingzhu Yang, Honghua Wu, Meng Wang, Yan Zhu. High-Throughput Electrophysiology Screen Revealed Cardiotoxicity of Strychnine by Selectively Targeting hERG Channel. The American journal of Chinese medicine. 2018; 46(8):1825-1840. doi: 10.1142/s0192415x1850091x. [PMID: 30545237]
  • Rutesh Savalia, Sanghamitra Chatterjee. Sensitive detection of brucine an anti-metastatic drug for hepatocellular carcinoma at carbon nanotubes - nafion composite based biosensor. Biosensors & bioelectronics. 2017 Dec; 98(?):371-377. doi: 10.1016/j.bios.2017.07.011. [PMID: 28709086]
  • Muhammad Ali Rajput, Rafeeq Alam Khan, Tahira Assad. Anti-epileptic activity of Nelumbo nucifera fruit. Metabolic brain disease. 2017 12; 32(6):1883-1887. doi: 10.1007/s11011-017-0064-7. [PMID: 28776277]
  • Min-Shan Lin, Wen-Chao Xiong, Shu-Ji Li, Zhi Gong, Xiong Cao, Xiao-Jing Kuang, Yuan Zhang, Tian-Ming Gao, Naguib Mechawar, Ce Liu, Xin-Hong Zhu. α2-glycine receptors modulate adult hippocampal neurogenesis and spatial memory. Developmental neurobiology. 2017 12; 77(12):1430-1441. doi: 10.1002/dneu.22549. [PMID: 29057625]
  • P N Prasad Maddisetty, V A Doss, Mohanasundaram S, Srinivasarao V, Mohanbabu T. HPLC and GC-MS: Identification and Quantification of Strychnine and Brucine in Strychnos nux-vomica leaves. Pakistan journal of pharmaceutical sciences. 2017 Nov; 30(6(Supplementary)):2369-2373. doi: . [PMID: 29188771]
  • Zsuzsanna Bardóczi, Balázs Pál, Áron Kőszeghy, Tamás Wilheim, Masahiko Watanabe, László Záborszky, Zsolt Liposits, Imre Kalló. Glycinergic Input to the Mouse Basal Forebrain Cholinergic Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 09; 37(39):9534-9549. doi: 10.1523/jneurosci.3348-16.2017. [PMID: 28874448]
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