Pimelic acid (BioDeep_00000001634)

 

Secondary id: BioDeep_00000405382

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


1,5-Pentanedicarboxylic acid

化学式: C7H12O4 (160.0735552)
中文名称: 庚二酸, 蒲桃酸
谱图信息: 最多检出来源 Homo sapiens(feces) 42.3%

分子结构信息

SMILES: C(C(=O)O)CCCCC(=O)O
InChI: InChI=1S/C7H12O4/c8-6(9)4-2-1-3-5-7(10)11/h1-5H2,(H,8,9)(H,10,11)

描述信息

Pimelic acid, also known as heptanedioic acid is a dicarboxylic acid. Derivatives of pimelic acid are involved in the biosynthesis of the amino acid called lysine. Pimelic acid is one methylene longer than a related dicarboxylic acid, adipic acid, a precursor to many polyesters and polyamides. Pimelic acid is essential for the synthesis of biotin (also called vitamin B7). Biotin is a heterocyclic, S-containing monocarboxylic acid that is made from two precursors, alanine and pimeloyl-CoA. Biotin is important in fatty acid synthesis, branched-chain amino acid catabolism, and gluconeogenesis. Biotin is found in a wide range of foods. Likewise, intestinal bacteria synthesize biotin, which is then absorbed by the host animal. Pimelic acid (which is the precursor for pimeloyl-CoA) is synthesized in many bacteria via a head-to-tail incorporation of acetate units through a modified fatty acid synthetic pathway using O-methyl esters disguised to resemble the canonical intermediates of the fatty acid synthetic pathway (PMID:21435937). Some bacteria and yeast synthesize pimelic acid not by biosynthesis, but via cleavage of longer chain fatty acids (such as linolenic acid) via a cytochrome P450-like enzyme (PMID:28196402, 21435937, 3236079). Pimelic acid is excreted in elevated amounts in the urine of individuals with mitochondrial beta-oxidation disorders and peroxisomal beta oxidation disorders (PMID:1527989)
A group of compounds that are derivatives of heptanedioic acid with the general formula R-C7H11O4.
KEIO_ID P063
Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.
Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.

同义名列表

21 个代谢物同义名

1,5-Pentanedicarboxylic acid; 1,5-Pentanedicarboxylate; Heptane-1,7-dioic acid; 6-Carboxyhexanoic acid; 1,7-Heptanedioic acid; Heptane-1,7-dioate; 6-Carboxyhexanoate; 1,7-Heptanedioate; Heptanedioic acid; Heptandioic acid; Acids, pimelic; Heptanedioate; Pimelic acids; Acid, pimelic; pimelic acid; Heptandioate; Pileric acid; Pilerate; Pimelate; Pimelate; Pimelic acid



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

26 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Pei-Pei Wei, Fu-Cheng Zhu, Cun-Wu Chen, Guo-Si Li. Engineering a heterologous synthetic pathway in Escherichia coli for efficient production of biotin. Biotechnology letters. 2021 Jun; 43(6):1221-1228. doi: 10.1007/s10529-021-03108-y. [PMID: 33666816]
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