Osthol (BioDeep_00000000159)

 

Secondary id: BioDeep_00000343458, BioDeep_00000859804

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H

化学式: C15H16O3 (244.1099)
中文名称: 蛇床子素, 欧芹酚甲醚, 蛇床籽素
谱图信息: 最多检出来源 Viridiplantae(otcml) 13.92%

分子结构信息

SMILES: CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C
InChI: InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3

描述信息

Osthol, also known as 7-methoxy-8-(3-methylpent-2-enyl)coumarin, belongs to coumarins and derivatives class of compounds. Those are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one). Osthol is practically insoluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Osthol can be found in a number of food items such as wild celery, lemon, parsley, and wild carrot, which makes osthol a potential biomarker for the consumption of these food products. Osthol is an O-methylated coumarin. It is a calcium channel blocker, found in plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens .
Osthole is a member of coumarins and a botanical anti-fungal agent. It has a role as a metabolite.
Osthole is a natural product found in Murraya alata, Pentaceras australe, and other organisms with data available.
See also: Angelica pubescens root (part of).
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
D007155 - Immunologic Factors
Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.
Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.
Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.

同义名列表

49 个代谢物同义名

InChI=1/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H; 7-Methoxy-8-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one; 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)-; Osthole, European Pharmacopoeia (EP) Reference Standard; 7-methoxy-8-(3-methyl-2-butenyl)-2h-1-benzopyran-2-one; 7-methoxy-8-(3-methyl-2-buten-1-yl)-2H-chromen-2-one; 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one; 7-Methoxy-8-(3-methyl-2-butenyl)-2H-chromen-2-one #; 7-methoxy-8-(3-methylbut-2-enyl)-1-benzopyran-2-one; Osthole, primary pharmaceutical reference standard; 7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one; 7-METHOXY-8-(3-METHYLBUT-2-ENYL)-2-CHROMENONE; 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one; Coumarin, 7-methoxy-8-(3-methyl-2-butenyl)-; 7-methoxy-8-(3-methylpent-2-enyl)coumarin; 7-METHOXY-8-(3-METHYL-2-BUTENYL)-COUMARIN; 7-methoxy-8-(3-methyl-2-butenyl)coumarin; 8-(3-Methyl-2-butenyl)herniarin; 7-Methoxy-8-isopentenylcoumarin; Osthole, analytical standard; MBRLOUHOWLUMFF-UHFFFAOYSA-N; WLN: T66 BOVJ IO1 J2UY1&1; Spectrum5_000334; Spectrum2_000723; Spectrum3_001645; Osthole (Osthol); Spectrum4_001687; UNII-XH1TI1759C; OSTHOLE [INCI]; Oprea1_642606; Oprea1_873803; DivK1c_007042; MEGxp0_000155; ACon1_002155; KBio2_004590; KBio2_002022; OSTHOLE [MI]; KBio1_001986; KBio2_007158; KBio3_002589; Osthole,(S); XH1TI1759C; Osthole; Osthol; Ostole; Ostol; A0O; NSC 31868; Osthol



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

75 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AKT1, BCL2, BDNF, CTNNB1, CYP3A4, MAPK14, MTOR, NFE2L2, PIK3CA, PRKAA2, PTGS2, RELA, VEGFA
Peripheral membrane protein 3 CYP1B1, MTOR, PTGS2
Endoplasmic reticulum membrane 5 BCL2, CYP1B1, CYP3A4, MTOR, PTGS2
Nucleus 9 AKT1, BCL2, CTNNB1, MAPK14, MTOR, NFE2L2, PRKAA2, RELA, VEGFA
cytosol 9 AKT1, BCL2, CTNNB1, MAPK14, MTOR, NFE2L2, PIK3CA, PRKAA2, RELA
dendrite 3 BDNF, MTOR, PRKAA2
phagocytic vesicle 1 MTOR
centrosome 2 CTNNB1, NFE2L2
nucleoplasm 7 AKT1, CTNNB1, MAPK14, MTOR, NFE2L2, PRKAA2, RELA
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 3 AKT1, CTNNB1, TNF
Cytoplasmic side 1 MTOR
lamellipodium 3 AKT1, CTNNB1, PIK3CA
Golgi apparatus membrane 1 MTOR
Synapse 1 CTNNB1
cell cortex 2 AKT1, CTNNB1
cell junction 1 CTNNB1
cell surface 2 TNF, VEGFA
glutamatergic synapse 4 AKT1, CTNNB1, MAPK14, RELA
Golgi apparatus 3 NFE2L2, PRKAA2, VEGFA
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 PRKAA2, TNF
postsynapse 1 AKT1
presynaptic membrane 1 CTNNB1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 MTOR
plasma membrane 6 AKT1, CTNNB1, NFE2L2, PIK3CA, TNF, TNFRSF11B
Membrane 9 AKT1, BCL2, BDNF, CTNNB1, CYP1B1, CYP3A4, MTOR, PRKAA2, VEGFA
axon 2 BDNF, PRKAA2
basolateral plasma membrane 1 CTNNB1
caveola 1 PTGS2
extracellular exosome 2 BMP3, CTNNB1
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, PTGS2, VEGFA
extracellular space 8 BDNF, BMP3, CCL2, IL6, INS, TNF, TNFRSF11B, VEGFA
perinuclear region of cytoplasm 3 BDNF, CTNNB1, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CTNNB1, VEGFA
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, CYP1B1, MAPK14
protein-containing complex 4 AKT1, BCL2, CTNNB1, PTGS2
intracellular membrane-bounded organelle 2 CYP1B1, CYP3A4
Microsome membrane 4 CYP1B1, CYP3A4, MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 7 BDNF, BMP3, CCL2, IL6, INS, TNFRSF11B, VEGFA
extracellular region 9 BDNF, BMP3, CCL2, IL6, INS, MAPK14, TNF, TNFRSF11B, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
transcription regulator complex 2 CTNNB1, RELA
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 AKT1
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 1 CTNNB1
spindle 1 AKT1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 2 TNFRSF11B, VEGFA
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 TNFRSF11B
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 NFE2L2, RELA
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 2 CTNNB1, MAPK14
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
nuclear envelope 1 MTOR
Endomembrane system 2 CTNNB1, MTOR
endosome lumen 1 INS
cytoplasmic stress granule 1 PRKAA2
euchromatin 1 CTNNB1
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BDNF, IL6, INS, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic active zone cytoplasmic component 1 CTNNB1
protein-DNA complex 2 CTNNB1, NFE2L2
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
beta-catenin-TCF7L2 complex 1 CTNNB1
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Tianshu Xu, Jiyuan Yin, Xuan Dai, Tianyuan Liu, Hanfen Shi, Yueyi Zhang, Shan Wang, Gaiyue Yue, Yanfei Zhang, Dandan Zhao, Sihua Gao, Marc Prentki, Lili Wang, Dongwei Zhang. Cnidii Fructus: A traditional Chinese medicine herb and source of antiosteoporotic drugs. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155375. doi: 10.1016/j.phymed.2024.155375. [PMID: 38507853]
  • Qiangsheng Li, Yifei Wang, Jia Yan, Ruyan Yuan, Jiamin Zhang, Xinhao Guo, Mingming Zhao, Fenfen Li, Xiaotian Li. Osthole ameliorates early diabetic kidney damage by suppressing oxidative stress, inflammation and inhibiting TGF-β1/Smads signaling pathway. International immunopharmacology. 2024 May; 133(?):112131. doi: 10.1016/j.intimp.2024.112131. [PMID: 38669945]
  • Wenwen Ding, Linhui Shangguan, Hongquan Li, Yinghui Bao, Fida Noor, Abdul Haseeb, Panpan Sun, Hua Zhang, Wei Yin, Kuohai Fan, Huizhen Yang, Zhenbiao Zhang, Na Sun. Dietary supplementation of osthole and icariin improves the production performance of laying hens by promoting follicular development. Poultry science. 2024 May; 103(5):103579. doi: 10.1016/j.psj.2024.103579. [PMID: 38430778]
  • Junkyu Park, Sujin Shin, Youngmin Bu, Ho-Young Choi, Kyungjin Lee. Vasorelaxant and Blood Pressure-Lowering Effects of Cnidium monnieri Fruit Ethanol Extract in Sprague Dawley and Spontaneously Hypertensive Rats. International journal of molecular sciences. 2024 Apr; 25(8):. doi: 10.3390/ijms25084223. [PMID: 38673809]
  • Wenjing Ta, Jie Wang, Jihong Song, Xingyue Li, Jianxiang Wang, Wen Lu. Elucidation the mechanism of the active ingredient imperatorin promoting drug absorption in cell model. The Journal of pharmacy and pharmacology. 2024 Jan; ?(?):. doi: 10.1093/jpp/rgad127. [PMID: 38215001]
  • Duo Lai, Delin Wang, Xuehua Shao, Jian Qin, Qingli Zhuang, Hanhong Xu, Weiqiang Xiao. Comparative physiological and transcriptome analysis provide insights into the inhibitory effect of osthole on Penicillium choerospondiatis. Pesticide biochemistry and physiology. 2024 Jan; 198(?):105749. doi: 10.1016/j.pestbp.2023.105749. [PMID: 38225092]
  • Zili Ren, Min Lv, Huqi Liu, Houpeng Wen, Yuling Zhang, Hui Xu. Optimization of Osthole as a Pesticide Candidate: Synthesis, Crystal Structures, and Agrochemical Properties of Acrylate Derivatives of Isopropenyl 2,3-Dihydrobenzofurans. Journal of agricultural and food chemistry. 2023 Nov; ?(?):. doi: 10.1021/acs.jafc.3c02213. [PMID: 37966481]
  • Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li. Natural product osthole can significantly disrupt cell wall integrity and dynamic balance of Fusarium oxysporum. Pesticide biochemistry and physiology. 2023 Nov; 196(?):105623. doi: 10.1016/j.pestbp.2023.105623. [PMID: 37945232]
  • Xianfeng Hu, Jian Wang, Yubo Zhang, Rongyu Li, Ming Li. Molecular mechanism of Osthole against chitin synthesis of Ustilaginoidea virens based on combined transcriptome and metabolome analyses. Pesticide biochemistry and physiology. 2023 Nov; 196(?):105612. doi: 10.1016/j.pestbp.2023.105612. [PMID: 37945229]
  • Jinman Liu, Qihui Wu, Qiqing Wu, Guangcheng Zhong, Yong Liang, Yong Gu, Yunhui Hu, Wenjia Wang, Ning Hao, Shuhuan Fang, Weirong Li, Huafeng Pan, Qi Wang, Jiansong Fang. Modulating endoplasmic reticulum stress in APP/PS1 mice by Gomisin B and Osthole in Bushen-Yizhi formula: Synergistic effects and therapeutic implications for Alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Oct; 119(?):155023. doi: 10.1016/j.phymed.2023.155023. [PMID: 37586159]
  • Pingping Wang, Zhenjun Fan, Wenping Wei, Chengshuai Yang, Yan Wang, Xiao Shen, Xing Yan, Zhihua Zhou. Biosynthesis of the Plant Coumarin Osthole by Engineered Saccharomyces cerevisiae. ACS synthetic biology. 2023 Jul; ?(?):. doi: 10.1021/acssynbio.3c00321. [PMID: 37450901]
  • Xinghua Zhou, Jian Kang, Liangliang Zhang, Yue Cheng. Osthole inhibits malignant phenotypes and induces ferroptosis in KRAS-mutant colorectal cancer cells via suppressing AMPK/Akt signaling. Cancer chemotherapy and pharmacology. 2023 Jun; ?(?):. doi: 10.1007/s00280-023-04549-0. [PMID: 37318525]
  • Jianwei Xu, Min Lv, Tianze Li, Houpeng Wen, Hui Xu. Optimization of Osthole in the Lactone Ring as an Agrochemical Candidate: Synthesis, Characterization, and Pesticidal Activities of Osthole Amide/Ester Derivatives and Their Effects on Morphological Changes of Mite Epidermis. Journal of agricultural and food chemistry. 2023 May; 71(17):6570-6583. doi: 10.1021/acs.jafc.3c00211. [PMID: 37083409]
  • Xin He, Min Nie, Mengyuan Wang, Shifei Wu, Xuemei Wei, Jiayuan Li, Changliang Yao, Chao Wang, Xiaochi Ma, De-An Guo. Microbial transformation of osthole by human intestinal fungi and anti-osteoporosis activities of its metabolites. Fitoterapia. 2023 Apr; 167(?):105510. doi: 10.1016/j.fitote.2023.105510. [PMID: 37075985]
  • Yi Cheng, Zhe Geng, Yunhe Li, Xu Song, Lixia Li, Anxiang Wen, Zhongqiong Yin. Effects of 'Shi Ying Zi' powder and osthole on immune and antioxidant function of Eimeria tenella-infected broilers. Experimental parasitology. 2023 Mar; 246(?):108451. doi: 10.1016/j.exppara.2022.108451. [PMID: 36584786]
  • Xiuyun Li, Chenglun Zhang, Enhui Wu, Liang Han, Xiangliang Deng, Zhongfeng Shi. UPLC-Q-TOF/MS-Based Metabolomics Approach Reveals Osthole Intervention in Breast Cancer 4T1 Cells. International journal of molecular sciences. 2023 Jan; 24(2):. doi: 10.3390/ijms24021168. [PMID: 36674685]
  • Zhe Ma, Lin Peng, Wenhui Chu, Pan Wang, Yongqian Fu. Osthole Alleviates D-Galactose-Induced Liver Injury In Vivo via the TLR4/MAPK/NF-κB Pathways. Molecules (Basel, Switzerland). 2023 Jan; 28(1):. doi: 10.3390/molecules28010443. [PMID: 36615637]
  • Feifei Wang, Peiming Yang, Tianhao Wan, Cong Liu, Yujuan Zhu, Xuzhuo Chen, Huanyan Liu. Osthole Inhibits M1 Macrophage Polarization and Attenuates Osteolysis in a Mouse Skull Model. Oxidative medicine and cellular longevity. 2023; 2023(?):2975193. doi: 10.1155/2023/2975193. [PMID: 36686380]
  • Bin Wu, Xiu-Fang Zhu, Xiao-Qiang Yang, Wei-Yi Wang, Jian-Hua Lu. Effects of osthole on osteoporotic rats: a systematic review and meta-analysis. Pharmaceutical biology. 2022 Dec; 60(1):1625-1634. doi: 10.1080/13880209.2022.2110267. [PMID: 35980123]
  • Meng Hao, Min Lv, Lin Zhou, Haijie Li, Jianwei Xu, Hui Xu. Construction, Pesticidal Activities, Control Effects, and Detoxification Enzyme Activities of Osthole Ester/Amide Derivatives. Journal of agricultural and food chemistry. 2022 Aug; 70(30):9337-9345. doi: 10.1021/acs.jafc.2c02534. [PMID: 35857419]
  • Zhiyan Liu, Meiyue Han, Xiaoting Yan, Wanqing Cheng, Zhenshuai Tang, Liping Cui, Ruige Yang, Yong Guo. Design, Synthesis, and Biological Evaluation of Novel Osthole-Based Isoxazoline Derivatives as Insecticide Candidates. Journal of agricultural and food chemistry. 2022 Jul; 70(26):7921-7928. doi: 10.1021/acs.jafc.2c01925. [PMID: 35731949]
  • Yue-Qiang Chen, Hai-Yan Song, Zhong-Yan Zhou, Jiao Ma, Zhan-Yang Luo, Ying Zhou, Jian-Yi Wang, Sheng Liu, Xiang-Hui Han. Osthole inhibits the migration and invasion of highly metastatic breast cancer cells by suppressing ITGα3/ITGβ5 signaling. Acta pharmacologica Sinica. 2022 Jun; 43(6):1544-1555. doi: 10.1038/s41401-021-00757-7. [PMID: 34426644]
  • Zheng Niu, Min Fu, Yuan Li, Huanhuan Ren, Xuanyu Zhang, Li Yao. Osthole alleviates pulmonary vascular remodeling by modulating microRNA-22-3p mediated lipid metabolic reprogramming. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Feb; 96(?):153840. doi: 10.1016/j.phymed.2021.153840. [PMID: 34836745]
  • Jin-Man Liu, Jun-Mei Chen, Ming-Jun Lin, Fan-Chang Wu, Cui-Ru Ma, Xue Zuo, Wen-Qian Yu, Ming-Jun Huang, Jian-Song Fang, Wei-Rong Li, Qi Wang, Yong Liang. Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma. Journal of ethnopharmacology. 2022 Jan; 282(?):114643. doi: 10.1016/j.jep.2021.114643. [PMID: 34534597]
  • Zili Ren, Min Lv, Hui Xu. Osthole: Synthesis, Structural Modifications, and Biological Properties. Mini reviews in medicinal chemistry. 2022; 22(16):2124-2137. doi: 10.2174/1389557522666220214101231. [PMID: 35156581]
  • Natalia Karolina Kordulewska, Justyna Topa, Robert Stryiński, Beata Jarmołowska. Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis. Cells. 2021 12; 11(1):. doi: 10.3390/cells11010088. [PMID: 35011650]
  • Nan Liu, Hao Tian, Guoduo Zhang, Na Sun, Shumei Wang. Effect of combined treatment with lobaplatin and osthole on inducing apoptosis and inhibiting proliferation in human breast cancer MDA-MB-231 cells. Medical oncology (Northwood, London, England). 2021 Nov; 39(1):16. doi: 10.1007/s12032-021-01609-4. [PMID: 34837558]
  • Arthur Neuberger, Kirill D Nadezhdin, Eleonora Zakharian, Alexander I Sobolevsky. Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole. EMBO reports. 2021 11; 22(11):e53233. doi: 10.15252/embr.202153233. [PMID: 34472684]
  • Ying-Nan Ni, Liang Kong, Xue-Tao Li, Hong-He Xiao, Yu-Tong Wu, Xi-Cai Liang, Ying Lin, Wan-Yi Li, Yan Deng, Yan Li, Yue Shi, Lan Cheng, Hong-Yan Li, Rui-Jun Ju, Jing-Xian Yang. Multifunctional osthole liposomes and brain targeting functionality with potential applications in a mouse model of Alzheimer's disease. Journal of liposome research. 2021 Sep; 31(3):267-278. doi: 10.1080/08982104.2020.1806872. [PMID: 32757676]
  • Shuo Yan, Qian Hu, Qinhong Jiang, Hongtao Chen, Jie Wei, Meizhen Yin, Xiangge Du, Jie Shen. Simple Osthole/Nanocarrier Pesticide Efficiently Controls Both Pests and Diseases Fulfilling the Need of Green Production of Strawberry. ACS applied materials & interfaces. 2021 Aug; 13(30):36350-36360. doi: 10.1021/acsami.1c09887. [PMID: 34283576]
  • Hongli Zheng, Yahan Chen, Qiuli Guo, Hong Wei, Jianying Yue, Hongyou Zhou, Mingmin Zhao. Inhibitory Effect of Osthole from Cnidium monnieri (L.) Cusson on Fusarium oxysporum, a Common Fungal Pathogen of Potato. Molecules (Basel, Switzerland). 2021 Jun; 26(13):. doi: 10.3390/molecules26133818. [PMID: 34201482]
  • Shaochen Li, Min Lv, Zhiqiang Sun, Meng Hao, Hui Xu. Optimization of Osthole in the Lactone Ring: Structural Elucidation, Pesticidal Activities, and Control Efficiency of Osthole Ester Derivatives. Journal of agricultural and food chemistry. 2021 Jun; 69(23):6465-6474. doi: 10.1021/acs.jafc.1c01434. [PMID: 34077224]
  • Yuying Guo, Jiabao Chen, Dan Ren, Bo Du, Lei Wu, Yuanyuan Zhang, Zhouyu Wang, Shan Qian. Synthesis of osthol-based botanical fungicides and their antifungal application in crop protection. Bioorganic & medicinal chemistry. 2021 06; 40(?):116184. doi: 10.1016/j.bmc.2021.116184. [PMID: 33971489]
  • Zili Ren, Min Lv, Zhiqiang Sun, Tianze Li, Shaoyong Zhang, Hui Xu. Regioselective hemisynthesis and insecticidal activity of C8-hydrazones/acylhydrazones/sulfonylhydrazones coumarin-type derivatives of osthole. Bioorganic & medicinal chemistry letters. 2021 05; 40(?):127962. doi: 10.1016/j.bmcl.2021.127962. [PMID: 33741463]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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  • Honghe Xiao, Yuying Wang, Yutong Wu, Hongyan Li, Xicai Liang, Yin Lin, Liang Kong, Yingnan Ni, Yan Deng, Yan Li, Wanyi Li, Jingxian Yang. Osthole ameliorates cognitive impairments via augmenting neuronal population in APP / PS1 transgenic mice. Neuroscience research. 2021 Mar; 164(?):33-45. doi: 10.1016/j.neures.2020.04.001. [PMID: 32302734]
  • Zhen-Xiong Jin, Xin-Yuan Liao, Wei-Wei Da, Yong-Jian Zhao, Xiao-Feng Li, De-Zhi Tang. Osthole enhances the bone mass of senile osteoporosis and stimulates the expression of osteoprotegerin by activating β-catenin signaling. Stem cell research & therapy. 2021 02; 12(1):154. doi: 10.1186/s13287-021-02228-6. [PMID: 33640026]
  • Fernando E García-Arroyo, Guillermo Gonzaga-Sánchez, Edilia Tapia, Itzel Muñoz-Jiménez, Lino Manterola-Romero, Horacio Osorio-Alonso, Abraham S Arellano-Buendía, José Pedraza-Chaverri, Carlos A Roncal-Jiménez, Miguel A Lanaspa, Richard J Johnson, Laura Gabriela Sánchez-Lozada. Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet. International journal of molecular sciences. 2021 Feb; 22(5):. doi: 10.3390/ijms22052431. [PMID: 33670975]
  • Saba Zafar, Iqra Sarfraz, Azhar Rasul, Muhammad Ajmal Shah, Ghulam Hussain, Muhammad Kashif Zahoor, Nusrat Shafiq, Ammara Riaz, Zeliha Selamoglu, Satyajit D Sarker. Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities. Mini reviews in medicinal chemistry. 2021; 21(18):2747-2763. doi: 10.2174/1389557520666200709175948. [PMID: 32646359]
  • Lijun Fang, Wei Wang, Jiazheng Chen, Anju Zuo, Hongmei Gao, Tao Yan, Pengqi Wang, Yujia Lu, Ruijuan Lv, Feng Xu, Yuguo Chen, Linmao Lyu. Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice. Oxidative medicine and cellular longevity. 2021; 2021(?):3309944. doi: 10.1155/2021/3309944. [PMID: 34527170]
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  • Joanna Sumorek-Wiadro, Adrian Zając, Ewa Langner, Krystyna Skalicka-Woźniak, Aleksandra Maciejczyk, Wojciech Rzeski, Joanna Jakubowicz-Gil. Antiglioma Potential of Coumarins Combined with Sorafenib. Molecules (Basel, Switzerland). 2020 Nov; 25(21):. doi: 10.3390/molecules25215192. [PMID: 33171577]
  • Zili Ren, Min Lv, Tianze Li, Meng Hao, Shaochen Li, Hui Xu. Construction of oxime ester derivatives of osthole from Cnidium monnieri, and evaluation of their agricultural activities and control efficiency. Pest management science. 2020 Nov; 76(11):3560-3567. doi: 10.1002/ps.6056. [PMID: 32815273]
  • Yinlan Xu, Panpan Sun, Shuangxiu Wan, Jianhua Guo, Xiaozhong Zheng, Yaogui Sun, Kuohai Fan, Wei Yin, Na Sun, Hongquan Li. The combined usage of Matrine and Osthole inhibited endoplasmic reticulum apoptosis induced by PCV2. BMC microbiology. 2020 10; 20(1):303. doi: 10.1186/s12866-020-01986-2. [PMID: 33046006]
  • Qingqing Yang, Lingwen Kong, Weiling Huang, Nabijan Mohammadtursun, Xiumin Li, Guifang Wang, Lixin Wang. Osthole attenuates ovalbumin‑induced lung inflammation via the inhibition of IL‑33/ST2 signaling in asthmatic mice. International journal of molecular medicine. 2020 Oct; 46(4):1389-1398. doi: 10.3892/ijmm.2020.4682. [PMID: 32700747]
  • Jun Ni, Qiaoyun Ren, Jin Luo, Ze Chen, Xiaofeng Xu, Junhui Guo, Yangchun Tan, Wenge Liu, Zhiqiang Qu, Zegong Wu, Jinming Wang, Youquan Li, Guiquan Guan, Jianxun Luo, Hong Yin, Guangyuan Liu. Ultrasound-assisted extraction extracts from Stemona japonica (Blume) Miq. and Cnidium monnieri (L.) Cuss. could be used as potential Rhipicephalus sanguineus control agents. Experimental parasitology. 2020 Oct; 217(?):107955. doi: 10.1016/j.exppara.2020.107955. [PMID: 32649953]
  • Yuchen Fan, Jiahong Wei, Li Guo, Siyu Zhao, Chenyu Xu, Hao Sun, Tao Guo. Osthole Reduces Mouse IOP Associated With Ameliorating Extracellular Matrix Expression of Trabecular Meshwork Cell. Investigative ophthalmology & visual science. 2020 08; 61(10):38. doi: 10.1167/iovs.61.10.38. [PMID: 32821914]
  • Hui He, Yuandong Zhang, Dezhang Zhao, Junhao Jiang, Baogang Xie, Limei Ma, Xueqing Liu, Chao Yu. Osthole inhibited the activity of CYP2C9 in human liver microsomes and influenced indomethacin pharmacokinetics in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2020 Aug; 50(8):939-946. doi: 10.1080/00498254.2020.1734882. [PMID: 32238050]
  • Junfeng Ye, Di Sun, Ying Yu, Jinhai Yu. Osthole resensitizes CD133+ hepatocellular carcinoma cells to cisplatin treatment via PTEN/AKT pathway. Aging. 2020 07; 12(14):14406-14417. doi: 10.18632/aging.103484. [PMID: 32673286]
  • Miriam Rossi, Sandjida Aktar, Marissa Davis, Emily Hefter Feuss, Samara Roman-Holba, Kelly Wen, Christopher Gahn, Francesco Caruso. The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies. Molecules (Basel, Switzerland). 2020 Jul; 25(14):. doi: 10.3390/molecules25143158. [PMID: 32664320]
  • Yanmei Feng, Qian Li, Lan Yang, Yu Zhang, Daiyu Qiu. The Use of 1H-qNMR Method for Simultaneous Determination of Osthol, Columbianadin, and Isoimperatorin in Angelicae Pubescentis Radix. Journal of AOAC International. 2020 Jun; 103(3):851-856. doi: 10.1093/jaoacint/qsz031. [PMID: 33241377]
  • Liang Kong, Xue-Tao Li, Ying-Nan Ni, Hong-He Xiao, Ying-Jia Yao, Yuan-Yuan Wang, Rui-Jun Ju, Hong-Yan Li, Jing-Jing Liu, Min Fu, Yu-Tong Wu, Jing-Xian Yang, Lan Cheng. Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer's Disease-Related Pathology in APP/PS-1 Mice. International journal of nanomedicine. 2020; 15(?):2841-2858. doi: 10.2147/ijn.s239608. [PMID: 32425521]
  • Milad Ashrafizadeh, Reza Mohammadinejad, Saeed Samarghandian, Habib Yaribeygi, Thomas P Johnston, Amirhossein Sahebkar. Anti-Tumor Effects of Osthole on Different Malignant Tissues: A Review of Molecular Mechanisms. Anti-cancer agents in medicinal chemistry. 2020; 20(8):918-931. doi: 10.2174/1871520620666200228110704. [PMID: 32108003]
  • Brianna N Callahan, Ananth K Kammala, Meesum Syed, Canchai Yang, Christopher J Occhiuto, Rithvik Nellutla, Alena P Chumanevich, Carole A Oskeritzian, Rupali Das, Hariharan Subramanian. Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses. Frontiers in immunology. 2020; 11(?):703. doi: 10.3389/fimmu.2020.00703. [PMID: 32391014]
  • Qiu-Yang Zhang, Shu-Ya Tao, Chang Lu, Jing-Jing Li, Xiu-Miao Li, Qin Jiang, Biao Yan. Osthole: A Traditional Chinese Medicine for Ocular Anti-Angiogenic Therapy. Ophthalmic research. 2020; 63(5):483-490. doi: 10.1159/000505976. [PMID: 31945770]
  • Ya-Han Chen, Dong-Sheng Guo, Mei-Huan Lu, Jian-Ying Yue, Yan Liu, Chun-Ming Shang, De-Rong An, Ming-Min Zhao. Inhibitory Effect of Osthole from Cnidium monnieri on Tobacco Mosaic Virus (TMV) Infection in Nicotiana glutinosa. Molecules (Basel, Switzerland). 2019 Dec; 25(1):. doi: 10.3390/molecules25010065. [PMID: 31878172]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jing-Mao You, Jie Guo, Zhe Li, Qin Yang, Yuan-Yuan Duan, Xiao-Liang Guo, Da-Ye Huang, Zhuang-Ling Zou, Han-Jiu Guo. [Isolation and identification of pathogen of Dendrobium officinale gray mold and its prevention and control]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Sep; 44(18):3954-3959. doi: 10.19540/j.cnki.cjcmm.2019730.101. [PMID: 31872730]
  • Ying Huang, Mingjie Sun, Haifeng Cui, Liting Kong, Huaqiang Zhai, Yanping Wang, Cheng Lü, Danping Fan. Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2019 08; 39(4):492-501. doi: . [PMID: 32186096]
  • Yuqiao Yang, Ruichao Zhu, Jin Li, Xuejing Yang, Jun He, Hui Wang, Yanxu Chang. Separation and Enrichment of Three Coumarins from Angelicae Pubescentis Radix by Macroporous Resin with Preparative HPLC and Evaluation of Their Anti-Inflammatory Activity. Molecules (Basel, Switzerland). 2019 Jul; 24(14):. doi: 10.3390/molecules24142664. [PMID: 31340484]
  • Natalia Karolina Kordulewska, Elżbieta Kostyra, Barbara Chwała, Małgorzata Moszyńska, Anna Cieślińska, Ewa Fiedorowicz, Beata Jarmołowska. A novel concept of immunological and allergy interactions in autism spectrum disorders: Molecular, anti-inflammatory effect of osthole. International immunopharmacology. 2019 Jul; 72(?):1-11. doi: 10.1016/j.intimp.2019.01.058. [PMID: 30953868]
  • Ying Lin, Xicai Liang, Yingjia Yao, Honghe Xiao, Yue Shi, Jingxian Yang. RETRACTED: Osthole attenuates APP-induced Alzheimer's disease through up-regulating miRNA-101a-3p. Life sciences. 2019 05; 225(?):117-131. doi: 10.1016/j.lfs.2019.04.004. [PMID: 30951743]
  • Xi Zhao, Jie Xue, Meilin Xie. Osthole inhibits oleic acid/lipopolysaccharide-induced lipid accumulation and inflammatory response through activating PPARα signaling pathway in cultured hepatocytes. Experimental gerontology. 2019 05; 119(?):7-13. doi: 10.1016/j.exger.2019.01.014. [PMID: 30659956]
  • Wen-Bo Zhou, Xin-Xin Zhang, Yun Cai, Wu Sun, Hao Li. Osthole prevents tamoxifen-induced liver injury in mice. Acta pharmacologica Sinica. 2019 May; 40(5):608-619. doi: 10.1038/s41401-018-0171-y. [PMID: 30315252]
  • Huaying Fan, Zhenfang Gao, Kai Ji, Xin Li, Jingbao Wu, Yue Liu, Xuekai Wang, Haiyue Liang, Yanan Liu, Xiaoting Li, Pan Liu, Daquan Chen, Feng Zhao. The in vitro and in vivo anti-inflammatory effect of osthole, the major natural coumarin from Cnidium monnieri (L.) Cuss, via the blocking of the activation of the NF-κB and MAPK/p38 pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 May; 58(?):152864. doi: 10.1016/j.phymed.2019.152864. [PMID: 30878874]
  • Liang Kong, Yingjia Yao, Yang Xia, Xicai Liang, Yingnan Ni, Jingxian Yang. Osthole alleviates inflammation by down-regulating NF-κB signaling pathway in traumatic brain injury. Immunopharmacology and immunotoxicology. 2019 Apr; 41(2):349-360. doi: 10.1080/08923973.2019.1608560. [PMID: 31056982]
  • Wei-Chih Kan, Jean-Yu Hwang, Lea-Yea Chuang, Jinn-Yuh Guh, Yi-Ling Ye, Yu-Lin Yang, Jau-Shyang Huang. Effect of osthole on advanced glycation end products-induced renal tubular hypertrophy and role of klotho in its mechanism of action. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Feb; 53(?):205-212. doi: 10.1016/j.phymed.2018.09.030. [PMID: 30668400]
  • Yingjia Yao, Yameng Wang, Liang Kong, Yuqing Chen, Jingxian Yang. RETRACTED: Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer's disease. Life sciences. 2019 01; 217(?):16-24. doi: 10.1016/j.lfs.2018.11.038. [PMID: 30471283]
  • Natalia Karolina Kordulewska, Anna Cieślińska, Ewa Fiedorowicz, Beata Jarmołowska, Elżbieta Kostyra. High Expression of IL-1RI and EP₂ Receptors in the IL-1β/COX-2 Pathway, and a New Alternative to Non-Steroidal Drugs-Osthole in Inhibition COX-2. International journal of molecular sciences. 2019 Jan; 20(1):. doi: 10.3390/ijms20010186. [PMID: 30620999]
  • Dongfeng Zhao, Qiang Wang, Yongjian Zhao, Hao Zhang, Nannan Sha, Dezhi Tang, Shufen Liu, Sheng Lu, Qi Shi, Yan Zhang, Yufeng Dong, Yongjun Wang, Bing Shu. The naturally derived small compound Osthole inhibits osteoclastogenesis to prevent ovariectomy-induced bone loss in mice. Menopause (New York, N.Y.). 2018 12; 25(12):1459-1469. doi: 10.1097/gme.0000000000001150. [PMID: 29944638]
  • Yuusuke Tashiro, Ryo Sakai, Tomoko Hirose-Sugiura, Yukio Kato, Hirotaka Matsuo, Tappei Takada, Hiroshi Suzuki, Toshiaki Makino. Effects of Osthol Isolated from Cnidium monnieri Fruit on Urate Transporter 1. Molecules (Basel, Switzerland). 2018 Nov; 23(11):. doi: 10.3390/molecules23112837. [PMID: 30388753]
  • Xiao-Ying Sun, Li-Lan Sun, Hang Qi, Qin Gao, Gong-Xin Wang, Ning-Ning Wei, KeWei Wang. Antipruritic Effect of Natural Coumarin Osthole through Selective Inhibition of Thermosensitive TRPV3 Channel in the Skin. Molecular pharmacology. 2018 10; 94(4):1164-1173. doi: 10.1124/mol.118.112466. [PMID: 30108138]
  • Huilong Yuan, Shuai Ouyang, Runan Yang, Shunhua Li, Yingxin Gong, Lifang Zou, Tianyu Jia, Shanhong Zhao, Bing Wu, Zhihua Yi, Hui Liu, Liran Shi, Lin Li, Yun Gao, Guilin Li, Hong Xu, Shuangmei Liu, Chunping Zhang, Shangdong Liang. Osthole alleviated diabetic neuropathic pain mediated by the P2X4 receptor in dorsal root ganglia. Brain research bulletin. 2018 09; 142(?):289-296. doi: 10.1016/j.brainresbull.2018.08.008. [PMID: 30118750]
  • Yingjia Yao, Xicai Liang, Yue Shi, Ying Lin, Jingxian Yang. Osthole Delays Tert-Butyl Hydroperoxide-Induced Premature Senescence in Neural Stem Cells. Cellular reprogramming. 2018 08; 20(4):268-274. doi: 10.1089/cell.2018.0010. [PMID: 29989446]
  • Chaojie Sun, Yun Gui, Rongfeng Hu, Jiayi Chen, Bin Wang, Yuxing Guo, Wenjie Lu, Xiangjiang Nie, Qiang Shen, Song Gao, Wenyou Fang. Preparation and Pharmacokinetics Evaluation of Solid Self-Microemulsifying Drug Delivery System (S-SMEDDS) of Osthole. AAPS PharmSciTech. 2018 Jul; 19(5):2301-2310. doi: 10.1208/s12249-018-1067-3. [PMID: 29845504]
  • Botao Wang, Xin Zheng, Jing Liu, Zhen Zhang, Chongyang Qiu, Lei Yang, Lanqiu Zhang, Qi Zhang, Hongwei Gao, Ximo Wang. Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumor-infiltrating M2 macrophages. Journal of pharmacological sciences. 2018 Jul; 137(3):290-298. doi: 10.1016/j.jphs.2018.07.007. [PMID: 30098910]
  • Nani Wang, Xuping Wang, Yang Zhang, Qiaoyan Zhang, Pingcui Xu, Hailiang Xin, Renjie Wu, Dan Shou, Luping Qin. Comparative metabolites profiles of osthole in normal and osteoporosis rats using liquid chromatography quadrupole time-of-flight mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2018 May; 154(?):460-467. doi: 10.1016/j.jpba.2018.03.036. [PMID: 29587226]
  • Ying Lin, Yingjia Yao, Xicai Liang, Yue Shi, Liang Kong, Honghe Xiao, Yutong Wu, Yingnan Ni, Jingxian Yang. [Osthole suppresses amyloid precursor protein expression by up-regulating miRNA-101a-3p in Alzheimer's disease cell model]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2018 05; 47(5):473-479. doi: 10.3785/j.issn.1008-9292.2018.10.05. [PMID: 30693688]
  • Li Yao, Yuxia Yang, Guanhong He, Chunqing Ou, Lan Wang, Kaixuan Liu. Global Proteomics Deciphered Novel-Function of Osthole Against Pulmonary Arterial Hypertension. Scientific reports. 2018 04; 8(1):5556. doi: 10.1038/s41598-018-23775-8. [PMID: 29615702]
  • Xi Zhao, Feng Wang, Ruijun Zhou, Zengyan Zhu, Meilin Xie. PPARα/γ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats. Inflammopharmacology. 2018 Apr; 26(2):425-433. doi: 10.1007/s10787-017-0327-2. [PMID: 28236037]
  • Qi Zhao, Xin-Mei Li, Hong-Ning Liu, Frank J Gonzalez, Fei Li. Metabolic map of osthole and its effect on lipids. Xenobiotica; the fate of foreign compounds in biological systems. 2018 Mar; 48(3):285-299. doi: 10.1080/00498254.2017.1306660. [PMID: 28287022]
  • Yuxin Bao, Xiaolin Meng, Fangning Liu, Fei Wang, Jinhui Yang, Haiyu Wang, Guanghong Xie. Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells. Molecular medicine reports. 2018 03; 17(3):4561-4566. doi: 10.3892/mmr.2018.8447. [PMID: 29344655]
  • Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm. 2018 Feb; 9(2):371-382. doi: 10.1039/c7md00388a. [PMID: 30108931]
  • Renguo Xu, Zhen Liu, Jiande Hou, Tao Huang, Ming Yang. Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress. Cellular & molecular biology letters. 2018; 23(?):19. doi: 10.1186/s11658-018-0086-0. [PMID: 29743895]
  • Yuhui Yan, Liang Kong, Yang Xia, Wenbo Liang, Litong Wang, Jie Song, Yingjia Yao, Ying Lin, Jingxian Yang. Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury. Brain, behavior, and immunity. 2018 Jan; 67(?):118-129. doi: 10.1016/j.bbi.2017.08.011. [PMID: 28823624]
  • Yun Cai, Wu Sun, Xin-Xin Zhang, Yan-Die Lin, Hao Chen, Hao Li. Osthole prevents acetaminophen-induced liver injury in mice. Acta pharmacologica Sinica. 2018 Jan; 39(1):74-84. doi: 10.1038/aps.2017.129. [PMID: 29022574]
  • Agata Jarząb, Jarogniew Łuszczki, Małgorzata Guz, Krystyna Skalicka-Woźniak, Marta Hałasa, Jolanta Smok-Kalwat, Krzysztof Polberg, Andrzej Stepulak. Combination of Osthole and Cisplatin Against Rhabdomyosarcoma TE671 Cells Yielded Additive Pharmacologic Interaction by Means of Isobolographic Analysis. Anticancer research. 2018 01; 38(1):205-210. doi: 10.21873/anticanres.12209. [PMID: 29277774]
  • Yiyi Jin, Jianchang Qian, Xin Ju, Xiaodong Bao, Li Li, Suqing Zheng, Xiong Chen, Zhongxiang Xiao, Xuemei Chen, Weiwei Zhu, Weixin Li, Wencan Wu, Guang Liang. Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. Mediators of inflammation. 2018; 2018(?):4934592. doi: 10.1155/2018/4934592. [PMID: 30057486]
  • Lin-Peng Li, Xiao-Juan Wang, Jin-Yu Zhang, Lu-Lu Zhang, Yong-Bing Cao, Li-Qun Gu, Yi-Qun Yu, Qi-Lian Yang, Chun-Ying Shen, Bing Han, Yuan-Ying Jiang. Antifungal activity of osthol in vitro and enhancement in vivo through Eudragit S100 nanocarriers. Virulence. 2018 01; 9(1):555-562. doi: 10.1080/21505594.2017.1356503. [PMID: 28795862]
  • Elina Karhu, Janne Isojärvi, Pia Vuorela, Leena Hanski, Adyary Fallarero. Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy. Journal of natural products. 2017 10; 80(10):2602-2608. doi: 10.1021/acs.jnatprod.6b01052. [PMID: 29043803]
  • Zhe Wang. Plant-derived antifungal compounds trigger a common transcriptional response. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2017 10; 54(?):1-3. doi: 10.1016/j.meegid.2017.06.014. [PMID: 28625541]
  • Lei Liu, Jun Mao, Qifei Wang, Zhiwei Zhang, Guangzhen Wu, Qizhen Tang, Bin Zhao, Lianhong Li, Quanlin Li. In vitro anticancer activities of osthole against renal cell carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Oct; 94(?):1020-1027. doi: 10.1016/j.biopha.2017.07.155. [PMID: 28810525]
  • Tao Huang, Zhen Dong. Osthole protects against inflammation in a rat model of chronic kidney failure via suppression of nuclear factor-κB, transforming growth factor-β1 and activation of phosphoinositide 3-kinase/protein kinase B/nuclear factor (erythroid-derived 2)-like 2 signaling. Molecular medicine reports. 2017 Oct; 16(4):4915-4921. doi: 10.3892/mmr.2017.7125. [PMID: 28765904]
  • Xingyang Zhu, Xiaoling Song, Kun Xie, Xue Zhang, Wei He, Fubao Liu. Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma. International journal of molecular medicine. 2017 Oct; 40(4):1143-1151. doi: 10.3892/ijmm.2017.3113. [PMID: 28902342]
  • Amila A Dissanayake, Baram A H Ameen, Muraleedharan G Nair. Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Compounds from Prangos haussknechtii. Journal of natural products. 2017 09; 80(9):2472-2477. doi: 10.1021/acs.jnatprod.7b00322. [PMID: 28885836]
  • Haitao Feng, Jin-Jian Lu, Yitao Wang, Lixia Pei, Xiuping Chen. Osthole inhibited TGF β-induced epithelial-mesenchymal transition (EMT) by suppressing NF-κB mediated Snail activation in lung cancer A549 cells. Cell adhesion & migration. 2017 Sep; 11(5-6):464-475. doi: 10.1080/19336918.2016.1259058. [PMID: 28146373]
  • Wen-Chung Huang, Po-Chen Liao, Chun-Hsun Huang, Sindy Hu, Shih-Chun Huang, Shu-Ju Wu. Osthole attenuates lipid accumulation, regulates the expression of inflammatory mediators, and increases antioxidants in FL83B cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jul; 91(?):78-87. doi: 10.1016/j.biopha.2017.04.051. [PMID: 28448873]
  • Dan-Dan Luo, Xiao-Ying Chen, Zhen-Biao Zhang, Chao-Yue Sun, Yi-Feng Zheng, Yu-Hong Liu, Xiu-Fen Wang, Qi Wang, Janis Ya-Xian Zhan, Zi-Ren Su. Different effects of (+)‑borneol and (‑)‑borneol on the pharmacokinetics of osthole in rats following oral administration. Molecular medicine reports. 2017 Jun; 15(6):4239-4246. doi: 10.3892/mmr.2017.6502. [PMID: 28440419]