Norfloxacin (BioDeep_00000001554)

human metabolite Endogenous blood metabolite Chemicals and Drugs

代谢物信息卡片

1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

化学式: C16H18FN3O3 (319.13321300000007)
中文名称: 诺氟沙星
谱图信息: 最多检出来源 Homo sapiens(blood) 0.59%

分子结构信息

SMILES: CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
InChI: InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

描述信息

Norfloxacin is only found in individuals that have used or taken this drug. It is a synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. [PubChem]The bactericidal action of Norfloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Norfloxacin is a broad-spectrum antibiotic that is active against both gram-positive and gram-negative bacterias. The fluorine atom at the 6 position increases potency against gram-negative organisms, and the piperazine moiety at the 7 position is responsible for anti-pseudomonal activity
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065609 - Cytochrome P-450 CYP1A2 Inhibitors
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AE - Fluoroquinolones
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
CONFIDENCE standard compound; EAWAG_UCHEM_ID 232
CONFIDENCE standard compound; INTERNAL_ID 1032

同义名列表

14 个代谢物同义名

1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid; 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylate; 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylate; 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure; Merck brand OF norfloxacin; Norfloxacin merck brand; Norfloxacinum; Norfloxacino; Norfloxacine; norfloxacin; Noroxin; NFLX

数据库引用编号

36 个数据库交叉引用编号

ChEBI: CHEBI:100246
KEGG: C06687
KEGGdrug: D00210
PubChem: 4539
HMDB: HMDB0015192
Metlin: METLIN1598
DrugBank: DB01059
ChEMBL: CHEMBL9
Wikipedia: Norfloxacin
MeSH: Norfloxacin
chemspider: 4380
CAS: 68077-27-0
CAS: 70458-96-7
MoNA: EA023208
MoNA: AU103205
MoNA: EA023202
MoNA: EA023210
MoNA: EA023206
MoNA: EA023211
MoNA: EA023212
MoNA: AU103204
MoNA: EA023207
MoNA: EA023203
MoNA: EA023214
MoNA: EA023205
MoNA: EA023201
MoNA: EA023209
MoNA: EA023213
MoNA: AU103201
MoNA: AU103202
MoNA: EA023204
MoNA: AU103203
PMhub: MS000000761
PubChem: 8912
NIKKAJI: J1.144D
RefMet: Norfloxacin

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Xiaoying Mu, Songhe Zhang, Jianhui Lu, Yangrui Huang, Jianghao Ji. Fate and removal of fluoroquinolone antibiotics in mesocosmic wetlands: Impact on wetland performance, resistance genes and microbial communities. Journal of hazardous materials. 2024 May; 470(?):133740. doi: 10.1016/j.jhazmat.2024.133740. [PMID: 38569335]
Pengwei Li, Ziheng Zhao, Miaomiao Zhang, Hang Su, Ting Zhao, Weisheng Feng, Zhijuan Zhang. Exploring the Potential of Biochar Derived from Chinese Herbal Medicine Residue for Efficient Removal of Norfloxacin. Molecules (Basel, Switzerland). 2024 Apr; 29(9):. doi: 10.3390/molecules29092063. [PMID: 38731553]
Meilian Huang, Yuanxiong Ma, Jin Qian, Inna M Sokolova, Caoqi Zhang, Khor Waiho, James Kar Hei Fang, Xiaowan Ma, Youji Wang, Menghong Hu. Combined effects of norfloxacin and polystyrene nanoparticles on the oxidative stress and gut health of the juvenile horseshoe crab Tachypleus tridentatus. Journal of hazardous materials. 2024 Apr; 468(?):133801. doi: 10.1016/j.jhazmat.2024.133801. [PMID: 38377908]
Baizhou Lu, Zhanqiang Fang, Pokeung Eric Tsang. Effect and mechanism of norfloxacin removal by Eucalyptus leaf extract enhanced the ZVI/H2O2 process. The Science of the total environment. 2024 Mar; 914(?):169820. doi: 10.1016/j.scitotenv.2023.169820. [PMID: 38199363]
Jinluo Fan, Chengjun Ge, Ailing Li, Guoliang Ren, Hui Deng, Dongming Wu, Jiwei Luo, Yanhu He, Yuanyuan Zhao, Jiatong Li, Dan Feng, Huamei Yu. The structural transformation reversibility of biogas slurry derived dissolved organic matter and its binding properties with norfloxacin under temperature fluctuation. Ecotoxicology and environmental safety. 2024 Feb; 271(?):115953. doi: 10.1016/j.ecoenv.2024.115953. [PMID: 38244512]
Gisele Canan-Rochenbach, Marco A B Barreiros, André O S Lima, Pascale Bauda, Eric Sanches-Simões, Wendell Pimentel-Almeida, Rafael Ariente-Neto, Cleder A Somensi, Tito C M Almeida, Rogério Corrêa, Claudemir M Radetski. Characterization of bacterial resistance in treated hospital wastewater. Environmental technology. 2024 Jan; 45(1):120-128. doi: 10.1080/09593330.2022.2100282. [PMID: 35802062]
Jianhui Lu, Xiaoying Mu, Songhe Zhang, Yingying Song, Yu Ma, Min Luo, Rufei Duan. Coupling of submerged macrophytes and epiphytic biofilms reduced methane emissions from wetlands: Evidenced by an antibiotic inhibition experiment. The Science of the total environment. 2023 Dec; 904(?):166710. doi: 10.1016/j.scitotenv.2023.166710. [PMID: 37652383]
Chen Wang, Peter E Holm, Mogens Larsen Andersen, Lisbeth Garbrecht Thygesen, Ulla Gro Nielsen, Hans Christian Bruun Hansen. Phosphorus doped cyanobacterial biochar catalyzes efficient persulfate oxidation of the antibiotic norfloxacin. Bioresource technology. 2023 Nov; 388(?):129785. doi: 10.1016/j.biortech.2023.129785. [PMID: 37722544]
R Ricky, S Shanthakumar. An investigation on removal of ciprofloxacin and norfloxacin by phycoremediation with an emphasis on acute toxicity and biochemical composition. Scientific reports. 2023 08; 13(1):13911. doi: 10.1038/s41598-023-41144-y. [PMID: 37626153]
Andressa Rezende Pereira, Lucimeire de Ávila Barbosa Fonseca, Aline Gomes de Oliveira Paranhos, Camila Cristina Rodrigues Ferreira da Cunha, Sérgio Francisco de Aquino, Silvana de Queiroz Silva. Role of a typical swine liquid manure treatment plant in reducing elements of antibiotic resistance. Environmental science and pollution research international. 2023 Aug; 30(40):91803-91817. doi: 10.1007/s11356-023-28823-z. [PMID: 37477815]
Raimundo Samuel Leite Sampaio, Raimundo Luiz Silva Pereira, Henrique Douglas Melo Coutinho, José Weverton Almeida-Bezerra, Maria Flaviana Bezerra Morais-Braga, Mariana Dos Santos Santana, Maria Elenilda Paulino da Silva, Antonia Thassya Lucas Dos Santos, Victor Juno Alencar Fonseca, Adrielle Rodrigues Costa, Viviane Bezerra da Silva, Felicidade Caroline Rodrigues, José Jailson Lima Bezerra, António Raposo, João Paulo Martins de Lima, Luiz Marivando Barros. Chemical composition and antimicrobial potential of Acrocomia aculeata (Jacq.) Lodd. ex Mart. and Syagrus cearensis Noblick (Arecaceae). Microbial pathogenesis. 2023 Jul; 180(?):106147. doi: 10.1016/j.micpath.2023.106147. [PMID: 37169312]
R Ricky, S Shanthakumar. A pilot-scale study on the removal of binary mixture (ciprofloxacin and norfloxacin) by Scenedesmus obliquus: Optimization, biotransformation, and biofuel profile. Journal of environmental management. 2023 Jun; 344(?):118388. doi: 10.1016/j.jenvman.2023.118388. [PMID: 37354597]
Lei Zhao, Zhenzhen Han, Mengying Zhou, Cong Lyu, Yu Li. Field measures of strengthen plant-microbial remediation of PAHs-FQs compound pollution. Environmental science and pollution research international. 2023 May; ?(?):. doi: 10.1007/s11356-023-27618-6. [PMID: 37202637]
Jiaojun Jin, Linling Xu, Siyi Zhang, MingKang Jin, Ping Zhang, Luoqin Shen, Jiayao Chen, Zhiheng Li, Wenlu Zhao, Huijun Liu. Oxidative response of rice (Oryza sativa L.) seedlings to quinolone antibiotics and its correlation with phyllosphere microbes and antibiotic resistance genes. The Science of the total environment. 2023 Apr; 867(?):161544. doi: 10.1016/j.scitotenv.2023.161544. [PMID: 36642277]
Olga V Tsepaeva, Andrey V Nemtarev, Tatiana N Pashirova, Michail V Khokhlachev, Anna P Lyubina, Syumbelya K Amerkhanova, Alexandra D Voloshina, Vladimir F Mironov. Novel triphenylphosphonium amphiphilic conjugates of glycerolipid type: synthesis, cytotoxic and antibacterial activity, and targeted cancer cell delivery. RSC medicinal chemistry. 2023 Mar; 14(3):454-469. doi: 10.1039/d2md00363e. [PMID: 36970146]
Baizhou Lu, Zhanqiang Fang, Pokeung Eric Tsang, Jinhua Wu. Effect and mechanism of norfloxacin removal by guava leaf extract in the ZVI/H2O2 system. Chemosphere. 2023 Mar; 316(?):137801. doi: 10.1016/j.chemosphere.2023.137801. [PMID: 36634715]
Tongtong Wang, Amit Kumar, Xin Wang, Di Zhang, Yi Zheng, Guogang Wang, Qingliang Cui, Jinjun Cai, Jiyong Zheng. Construction of activated biochar/Bi2WO6 and /Bi2MoO6 composites to enhance adsorption and photocatalysis performance for efficient application in the removal of pollutants and disinfection. Environmental science and pollution research international. 2023 Mar; 30(11):30493-30513. doi: 10.1007/s11356-022-24049-7. [PMID: 36434458]
Camilo Rivera-Vera, Daniela Muñoz-Lira, Mario Aranda, Carla Toledo-Neira, Ricardo Salazar. Study of degradation of norfloxacin antibiotic and their intermediates by natural solar photolysis. Environmental science and pollution research international. 2023 Mar; 30(14):41014-41027. doi: 10.1007/s11356-022-24891-9. [PMID: 36626055]
Si-Qi Zhang, Ping Li, Shu-Wen He, Shao-Ying Xing, Zhi-Han Cao, Xue-Li Zhao, Cuici Sun, Zhi-Hua Li. Assessing the ecotoxicity of combined exposure to triphenyltin and norfloxacin at environmental levels: A case study of immunotoxicity and metabolic regulation in carp (Cyprinus carpio). Chemosphere. 2023 Feb; 313(?):137381. doi: 10.1016/j.chemosphere.2022.137381. [PMID: 36435316]
Ling Zhang, Junhong Bai, Kegang Zhang, Yaqi Wang, Rong Xiao, Marco Campos, Jacquelinne Acuña, Milko A Jorquera. Occurrence, bioaccumulation and ecological risks of antibiotics in the water-plant-sediment systems in different functional areas of the largest shallow lake in North China: Impacts of river input and historical agricultural activities. The Science of the total environment. 2023 Jan; 857(Pt 1):159260. doi: 10.1016/j.scitotenv.2022.159260. [PMID: 36208765]
Kiran Yasmin Khan, Guanlin Li, Daolin Du, Barkat Ali, Shuang Zhang, Meiying Zhong, Peter Joseph Stoffella, Babar Iqbal, Xiaoqiang Cui, Lijiang Fu, Ya Guo. Impact of polystyrene microplastics with combined contamination of norfloxacin and sulfadiazine on Chrysanthemum coronarium L. Environmental pollution (Barking, Essex : 1987). 2023 Jan; 316(Pt 1):120522. doi: 10.1016/j.envpol.2022.120522. [PMID: 36309303]
Kyung-Hyo Do, Kwang Won Seo, Jae-Won Byun, Wan-Kyu Lee. Relationship between virulence factors and antimicrobial resistance genes of pathogenic Escherichia coli from diarrheic weaned piglets. Research in veterinary science. 2022 Dec; 150(?):137-143. doi: 10.1016/j.rvsc.2022.05.007. [PMID: 35830753]
Yue Liu, Xiaoxia Sun, Jincan Zhang, Feng Gao, Leilei Yu, Lina Dong, Gangli Zhang, Changxin Wu. Isolation and characterisation of Pulsatilla Radix-utilising bacteria Pediococcus pentosaceus PR-1 from human faeces. FEMS microbiology letters. 2022 10; 369(1):. doi: 10.1093/femsle/fnac089. [PMID: 36073496]
Chen Wang, Hans Christian Bruun Hansen, Mogens Larsen Andersen, Bjarne W Strobel, Hui Ma, Nadia Dodge, Poul Erik Jensen, Changyong Lu, Peter E Holm. Fast peroxydisulfate oxidation of the antibiotic norfloxacin catalyzed by cyanobacterial biochar. Journal of hazardous materials. 2022 10; 439(?):129655. doi: 10.1016/j.jhazmat.2022.129655. [PMID: 35901634]
Kui Yang, Hui Lin, Xingwei Feng, Jin Jiang, Jinxing Ma, Zhifeng Yang. Energy-efficient removal of trace antibiotics from low-conductivity water using a Ti4O7 reactive electrochemical ceramic membrane: Matrix effects and implications for byproduct formation. Water research. 2022 Oct; 224(?):119047. doi: 10.1016/j.watres.2022.119047. [PMID: 36103779]
Junjun Feng, Haiyun Jiang, Jing Wang, Zhengyi Jing, Fan Zhang, Tianyu Tan, Feng He, Lihua Jiang, Haiqin Li, Shimin Chang, Tengfei Li. [Simultaneous determination of 40 plant growth regulators, fungicides, insecticides, and antibiotics in bean sprouts by QuEChERS-high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2022 Sep; 40(9):843-853. doi: 10.3724/sp.j.1123.2021.12028. [PMID: 36156631]
Xue-Li Zhao, Ping Li, Chunfeng Qu, Rong Lu, Zhi-Hua Li. Phytotoxicity of environmental norfloxacin concentrations on the aquatic plant Spirodela polyrrhiza: Evaluation of growth parameters, photosynthetic toxicity and biochemical traits. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Aug; 258(?):109365. doi: 10.1016/j.cbpc.2022.109365. [PMID: 35525467]
Xuewen Cao, Zhaofu Meng, En Song, Xiuxian Sun, Xiaolong Hu, Wenbin Li, Ze Liu, Shuai Gao, Bing Song. Co-adsorption capabilities and mechanisms of bentonite enhanced sludge biochar for de-risking norfloxacin and Cu2+ contaminated water. Chemosphere. 2022 Jul; 299(?):134414. doi: 10.1016/j.chemosphere.2022.134414. [PMID: 35346740]
Zhuoqun Wang, Yan Yang, Yingchun Mu, Bo Liu, Pei Zhang, Xin Zhang, Huiwu Sun, Yi Song, Bo Cheng. Pharmacokinetics and residue elimination of norfloxacin in rainbow trout (Oncorhynchus mykiss). Journal of veterinary pharmacology and therapeutics. 2022 May; 45(3):301-310. doi: 10.1111/jvp.13046. [PMID: 35225357]
Xun-Cai Yang, Peng-Li Zhang, Kannekanti Vijaya Kumar, Shuo Li, Rong-Xia Geng, Cheng-He Zhou. Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents. European journal of medicinal chemistry. 2022 Mar; 232(?):114192. doi: 10.1016/j.ejmech.2022.114192. [PMID: 35168149]
Bihui Niu, Luhan Wang, Mingzhe Li, Wenli Yao, Kun Zang, Lei Zhou, Xiaowen Hu, Yian Zheng. Lattice B-doping evolved ferromagnetic perovskite-like catalyst for enhancing persulfate-based degradation of norfloxacin. Journal of hazardous materials. 2022 03; 425(?):127949. doi: 10.1016/j.jhazmat.2021.127949. [PMID: 34883372]
Vigyasa Singh, Anirban Pal, Mahendra P Darokar. Glabridin synergy with norfloxacin induces ROS in multidrug resistant Staphylococcus aureus. The Journal of general and applied microbiology. 2021 Dec; 67(6):269-272. doi: 10.2323/jgam.2021.06.002. [PMID: 34690227]
Nisha Mahey, Rushikesh Tambat, Nishtha Chandal, Dipesh Kumar Verma, Krishan Gopal Thakur, Hemraj Nandanwar. Repurposing Approved Drugs as Fluoroquinolone Potentiators to Overcome Efflux Pump Resistance in Staphylococcus aureus. Microbiology spectrum. 2021 12; 9(3):e0095121. doi: 10.1128/spectrum.00951-21. [PMID: 34908453]
Si-Qi Zhang, Ping Li, Xue-Li Zhao, Shu-Wen He, Shao-Ying Xing, Zhi-Han Cao, Hai-Qi Zhang, Zhi-Hua Li. Hepatotoxicity in carp (Cyprinus carpio) exposed to environmental levels of norfloxacin (NOR): Some latest evidences from transcriptomics analysis, biochemical parameters and histopathological changes. Chemosphere. 2021 Nov; 283(?):131210. doi: 10.1016/j.chemosphere.2021.131210. [PMID: 34146880]
Simin Li, Jin Li, Zhu Li, Xin Ke, Longhua Wu, Peter Christie. Toxic effects of norfloxacin in soil on fed and unfed Folsomia candida (Isotomidae: Collembola) and on gut and soil microbiota. The Science of the total environment. 2021 Sep; 788(?):147793. doi: 10.1016/j.scitotenv.2021.147793. [PMID: 34034166]
Wei Shang, Bin Qiao, Qiu-Man Xu, Jing-Sheng Cheng. Potential biotransformation pathways and efficiencies of ciprofloxacin and norfloxacin by an activated sludge consortium. The Science of the total environment. 2021 Sep; 785(?):147379. doi: 10.1016/j.scitotenv.2021.147379. [PMID: 33957591]
Li Xue, Chaoxia Zhao, Qi Mo, Yanping Zhou, Kama Huang. An electrodeless atmospheric microwave plasma jet for efficient degradation of antibiotic norfloxacin. Journal of environmental management. 2021 Aug; 291(?):112729. doi: 10.1016/j.jenvman.2021.112729. [PMID: 33965705]
Nehal Salahuddin, Mohamed Gaber, Sahar Elneanaey, Michael R Snowdon, Mohamed A Abdelwahab. Co-delivery of norfloxacin and tenoxicam in Ag-TiO2/poly(lactic acid) nanohybrid. International journal of biological macromolecules. 2021 Jun; 180(?):771-781. doi: 10.1016/j.ijbiomac.2021.03.033. [PMID: 33705836]
Xin-Xin Wang, Zhao-Fu Meng, Xin Liu, Teng Wang, Xiao-Long Hu, Xiu-Xian Sun. [Adsorption of BS-18 Amphoterically Modified Bentonite to Tetracycline and Norfloxacin Combined Pollutants]. Huan jing ke xue= Huanjing kexue. 2021 May; 42(5):2334-2342. doi: 10.13227/j.hjkx.202009048. [PMID: 33884803]
Abdulaziz M Al-Mahallawi, Aly A Abdelbary, Sally A El-Zahaby. Norfloxacin loaded nano-cubosomes for enhanced management of otitis externa: In vitro and in vivo evaluation. International journal of pharmaceutics. 2021 May; 600(?):120490. doi: 10.1016/j.ijpharm.2021.120490. [PMID: 33744451]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Yonggui Zhao, Shiqi Zhang, Xiangdi Shu, Yuejiao Yang, Ya Li, JinQuan Chen, Ying Pan, Shucun Sun. Effects of norfloxacin on decomposition and nutrient release in leaves of the submerged macrophyte Vallisneria natans (Lour.) Hara. Environmental pollution (Barking, Essex : 1987). 2021 Apr; 274(?):116557. doi: 10.1016/j.envpol.2021.116557. [PMID: 33529893]
Heesu Kim, Dong Gun Lee. Lupeol-induced nitric oxide elicits apoptosis-like death within Escherichia coli in a DNA fragmentation-independent manner. The Biochemical journal. 2021 02; 478(4):855-869. doi: 10.1042/bcj20200925. [PMID: 33522568]
Jonas Nascimento de Sousa, Aylla Beatriz Melo de Oliveira, Andressa Kelly Ferreira, E Silva, Leide Maria Soares de Sousa, Melissa Carvalho França Rocha, José Pinto de, Siqueira Júnior, Glenn William Kaatz, Jackson Roberto Guedes da Silva Almeida, João Sammy Nery de Souza, Humberto Medeiros Barreto. Modulation of the resistance to norfloxacin in Staphylococcus aureus by Bauhinia forficata link. Natural product research. 2021 Feb; 35(4):681-685. doi: 10.1080/14786419.2019.1590714. [PMID: 30938178]
Sucheta Singh, Surjeet Verma, Dharmendra K Yadav, Anant Kumar, Rekha Tyagi, Priyanka Gupta, Dnyaneshwar U Bawankule, Mahendra P Darokar, Santosh K Srivastava, Alok Kalra. The Bioactive Potential of Culturable Fungal Endophytes Isolated From the Leaf of Catharanthus roseus (L.) G. Don. Current topics in medicinal chemistry. 2021; 21(10):895-907. doi: 10.2174/1568026621666210426123437. [PMID: 33902419]
Minghui Wang, Ruixuan Gao, Mengmeng Zheng, Peng Sang, Chunpu Li, En Zhang, Qi Li, Jianfeng Cai. Development of Bis-cyclic Imidazolidine-4-one Derivatives as Potent Antibacterial Agents. Journal of medicinal chemistry. 2020 12; 63(24):15591-15602. doi: 10.1021/acs.jmedchem.0c00171. [PMID: 32914977]
Huihui Han, Ting Li, Zhenlong Wang, Da Teng, Ruoyu Mao, Ya Hao, Na Yang, Xiumin Wang, Jianhua Wang. Improved Stability and Activity of a Marine Peptide-N6NH2 against Edwardsiella tarda and Its Preliminary Application in Fish. Marine drugs. 2020 Dec; 18(12):. doi: 10.3390/md18120650. [PMID: 33348729]
Zhong-Lin Sun, Shi-Chang Sun, Jian-Ming He, Jiang-Er Lan, Simon Gibbons, Qing Mu. Synergism of sophoraflavanone G with norfloxacin against effluxing antibiotic-resistant Staphylococcus aureus. International journal of antimicrobial agents. 2020 Sep; 56(3):106098. doi: 10.1016/j.ijantimicag.2020.106098. [PMID: 32707171]
Ting Yang, Ting-Jun Fan, Bin Xu. Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells. Toxicology in vitro : an international journal published in association with BIBRA. 2020 Aug; 66(?):104868. doi: 10.1016/j.tiv.2020.104868. [PMID: 32320760]
Dawood Al-Ajmi, Shafeeq Rahman, Sharmila Banu. Occurrence, virulence genes, and antimicrobial profiles of Escherichia coli O157 isolated from ruminants slaughtered in Al Ain, United Arab Emirates. BMC microbiology. 2020 07; 20(1):210. doi: 10.1186/s12866-020-01899-0. [PMID: 32677884]
Amit K Yadav, Tarun K Dhiman, G B V S Lakshmi, Anna N Berlina, Pratima R Solanki. A highly sensitive label-free amperometric biosensor for norfloxacin detection based on chitosan-yttria nanocomposite. International journal of biological macromolecules. 2020 May; 151(?):566-575. doi: 10.1016/j.ijbiomac.2020.02.089. [PMID: 32057869]
Suellen Menezes-Silva, Narlize Silva Lira, Yuri Mangueira do Nascimento, Roseana Araújo Ramos Meireles, Celidarque da Silva Dias, Josean Fechine Tavares, Marcelo Sobral da Silva, George Emmanuel Cavalcanti de Miranda, José Maria Barbosa Filho, José Pinto de Siqueira-Junior. Modulation of drug resistance in Staphylococcus aureus by 132-hydroxy-(132-R/S)-pheophytin isolated from Sargassum polyceratium. Microbial pathogenesis. 2020 Apr; 141(?):104034. doi: 10.1016/j.micpath.2020.104034. [PMID: 32007619]
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