Bicalutamide (BioDeep_00000001531)

 

Secondary id: BioDeep_00000397768

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


4-Cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3-(trifluoromethyl)propionanilide

化学式: C18H14F4N2O4S (430.061)
中文名称: 毕卡鲁胺
谱图信息: 最多检出来源 Homo sapiens(blood) 12.95%

分子结构信息

SMILES: CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
InChI: InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)

描述信息

Bicalutamide is only found in individuals that have used or taken this drug. It is an oral non-steroidal anti-androgen for prostate cancer. It binds to the androgen receptor.Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue.
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02B - Hormone antagonists and related agents > L02BB - Anti-androgens
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D000726 - Androgen Antagonists
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C146993 - Androgen Receptor Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C242 - Anti-Androgen
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000970 - Antineoplastic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

8 个代谢物同义名

4-Cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3-(trifluoromethyl)propionanilide; AstraZeneca brand OF bicalutamide; Zeneca brand OF bicalutamide; Astra brand OF bicalutamide; Bicalutamide; Casodex; Cosudex; Bicalutamide



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, AR, BCL2, CASP3, CDKN1A, EGFR, ERBB2, MSMP, MTOR, PIK3CA, PTEN, STAT3, TNK1, TP53
Peripheral membrane protein 2 MTOR, TNK1
Endosome membrane 2 EGFR, ERBB2
Endoplasmic reticulum membrane 4 BCL2, CYP19A1, EGFR, MTOR
Nucleus 13 ACP3, AKT1, AR, BCL2, CASP3, CDKN1A, EGFR, ERBB2, KLK3, MTOR, PTEN, STAT3, TP53
cytosol 12 ACP3, AKT1, AR, BCL2, CASP3, CDKN1A, ERBB2, MTOR, PIK3CA, PTEN, STAT3, TP53
dendrite 1 MTOR
nuclear body 1 CDKN1A
phagocytic vesicle 1 MTOR
centrosome 1 TP53
nucleoplasm 10 AKT1, AR, CASP3, CDKN1A, ERBB2, MTOR, PTEN, STAT3, TMPRSS2, TP53
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 4 AKT1, EGFR, ERBB2, TMPRSS2
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, PIK3CA
ruffle membrane 2 EGFR, ERBB2
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 CYP19A1
Golgi apparatus membrane 1 MTOR
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 3 AKT1, CASP3, EGFR
Golgi membrane 2 EGFR, MTOR
lysosomal membrane 2 ACP3, MTOR
neuromuscular junction 1 ERBB2
neuronal cell body 1 CASP3
postsynapse 1 AKT1
presynaptic membrane 1 ERBB2
Cytoplasm, cytosol 1 ACP3
Lysosome 2 ACP3, MTOR
endosome 1 EGFR
plasma membrane 11 ACP3, AKT1, AR, EGFR, ERBB2, KLK3, PIK3CA, PTEN, STAT3, TMPRSS2, TNK1
Membrane 10 AKT1, AR, BCL2, CYP19A1, EGFR, ERBB2, MTOR, TMPRSS2, TNK1, TP53
apical plasma membrane 3 EGFR, ERBB2, PTEN
basolateral plasma membrane 2 EGFR, ERBB2
extracellular exosome 3 ACP3, KLK3, TMPRSS2
Lysosome membrane 2 ACP3, MTOR
endoplasmic reticulum 3 BCL2, CYP19A1, TP53
extracellular space 6 ACP3, EGFR, GNRH1, IL6, KLK3, MSMP
perinuclear region of cytoplasm 4 CDKN1A, EGFR, ERBB2, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, TP53
protein-containing complex 7 AKT1, AR, BCL2, CDKN1A, EGFR, KLK3, TP53
Microsome membrane 2 CYP19A1, MTOR
filopodium 1 ACP3
postsynaptic density 2 CASP3, PTEN
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 3 ACP3, EGFR, ERBB2
Secreted 2 IL6, MSMP
extracellular region 6 ERBB2, GNRH1, IL6, KLK3, PTEN, TMPRSS2
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 2 STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
multivesicular body 1 ACP3
dendritic spine 1 PTEN
cytoplasmic vesicle 1 ERBB2
microtubule cytoskeleton 1 AKT1
nucleolus 2 CDKN1A, TP53
Early endosome 1 ERBB2
apical part of cell 1 ACP3
cell-cell junction 1 AKT1
Single-pass type II membrane protein 1 TMPRSS2
vesicle 1 AKT1
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 1 EGFR
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 EGFR
spindle 1 AKT1
intracellular vesicle 1 EGFR
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 3 MTOR, PTEN, TP53
PML body 3 MTOR, PTEN, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 KLK3
nuclear speck 1 AR
receptor complex 2 EGFR, ERBB2
Cell projection, neuron projection 1 PTEN
neuron projection 1 PTEN
ciliary basal body 1 AKT1
chromatin 3 AR, STAT3, TP53
cell projection 1 PTEN
[Isoform 2]: Cell membrane 1 ACP3
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 2 BCL2, ERBB2
basal plasma membrane 2 EGFR, ERBB2
synaptic membrane 1 EGFR
endoplasmic reticulum lumen 1 IL6
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule membrane 1 ACP3
Schmidt-Lanterman incisure 1 PTEN
Golgi cisterna 1 ACP3
semaphorin receptor complex 1 ERBB2
vesicle membrane 1 ACP3
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 TP53
[Transmembrane protease serine 2 catalytic chain]: Secreted 1 TMPRSS2
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 ERBB2
Cytoplasmic vesicle, phagosome 1 MTOR
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Isoform 1]: Secreted 1 ACP3
ERBB3:ERBB2 complex 1 ERBB2
interleukin-6 receptor complex 1 IL6
myelin sheath adaxonal region 1 PTEN
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
[Isoform alpha]: Secreted 1 PTEN
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Akira Yokomizo, Masaki Shiota, Futoshi Morokuma, Masatoshi Eto, Hideyasu Matsuyama, Hiroaki Matsumoto, Toshiyuki Kamoto, Naoki Terada, Kazuya Kawahara, Hideki Enokida, Shuichi Tatarano, Naohiro Fujimoto, Katsuyoshi Higasijima, Hideki Sakai, Tomoaki Hakariya, Tsukasa Igawa, Shigetaka Suekane, Tomomi Kamba, Yutaka Sugiyama, Junji Kishimoto, Seiji Naito. GnRH antagonist monotherapy versus a GnRH agonist plus bicalutamide for advanced hormone-sensitive prostate cancer; KYUCOG-1401. International journal of urology : official journal of the Japanese Urological Association. 2023 Dec; ?(?):. doi: 10.1111/iju.15371. [PMID: 38148124]
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  • Mohammadreza Mahdavijalal, Homayon Ahmad Panahi, Ali Niazi, Atefeh Tamaddon. Near-infrared light responsive dendrimers facilitate the extraction of bicalutamide from human plasma and urine. Biotechnology journal. 2021 Dec; 16(12):e2100299. doi: 10.1002/biot.202100299. [PMID: 34519173]
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