Schizandrin (BioDeep_00000000151)

Main id: BioDeep_00000398488

 

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.0²,⁷]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol

化学式: C24H32O7 (432.2147922)
中文名称: 五味子醇甲
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3CC1(C)O)OC)OC)OC)OC)OC)OC
InChI: InChI=1S/C24H32O7/c1-13-9-14-10-16(26-3)20(28-5)22(30-7)18(14)19-15(12-24(13,2)25)11-17(27-4)21(29-6)23(19)31-8/h10-11,13,25H,9,12H2,1-8H3

描述信息

A polyphenol metabolite detected in biological fluids [PhenolExplorer]
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats[1][2][3].
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats[1][2][3].

同义名列表

7 个代谢物同义名

3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.0²,⁷]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol; schizandrol A; Wuweizisu A; Schizandrin; Schisandrin; Schizandrol; Schizandrol-A



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jingxian Feng, Yuan Yao, Yuqi Qiao, Xueqi Ma, Zongtai Wu, Yonghao Duan, Peng Di, Wansheng Chen, Ying Xiao. Effect of pinoresinol-lariciresinol reductases on biosynthesis of lignans with substrate selectivity in Schisandra chinensis. Phytochemistry. 2024 May; 221(?):114053. doi: 10.1016/j.phytochem.2024.114053. [PMID: 38479587]
  • Shujun Chen, Fang Qin, Ying Yang, Yu Zhao, Shuyun Xiao, Wei Li, Toshihiro Akihisa, Pensak Jantrawut, Jingyu Ji, Jie Zhang. Extraction, purification, structural characterization, and bioactivities of the genus Schisandra polysaccharides: A review. International journal of biological macromolecules. 2024 Mar; 262(Pt 1):130257. doi: 10.1016/j.ijbiomac.2024.130257. [PMID: 38423904]
  • Qingyu Cao, Jiaqi Liu, Peiliang Dong, Hua Han. Different ratios of Schisandra chinensis and Evodia rutaecarpa combination for treating Alzheimer's disease. Experimental biology and medicine (Maywood, N.J.). 2023 10; 248(20):1877-1886. doi: 10.1177/15353702231199075. [PMID: 37787050]
  • Yiping Yan, Wenpeng Lu, Taiping Tian, Nan Shu, Yiming Yang, Shutian Fan, Xianyan Han, Yunhua Ge, Peilei Xu. Analysis of Volatile Components in Dried Fruits and Branch Exudates of Schisandra chinensis with Different Fruit Colors Using GC-IMS Technology. Molecules (Basel, Switzerland). 2023 Sep; 28(19):. doi: 10.3390/molecules28196865. [PMID: 37836708]
  • Xiaohu Wang, Xingwen Wang, Hui Yao, Chaozhuang Shen, Kuo Geng, Haitang Xie. A comprehensive review on Schisandrin and its pharmacological features. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Sep; ?(?):. doi: 10.1007/s00210-023-02687-z. [PMID: 37658213]
  • Truong Thi Thu Hien, Hoang Dac Thang, Hoang Anh Tuan, Pham The Tai, Nguyen Minh Tung, Nguyen Van Khoi, Nguyen Thi Thu Hien, Le Huyen Tram, Phan Van Kiem, Nguyen Xuan Nhiem, Bui Huu Tai, Jinyoung Kim, Junjung Choi, Seung Hyun Kim. Four new lignans obtained from the leaves of Schisandra cauliflora and their effect on skeletal muscle cell proliferation. Journal of natural medicines. 2023 Sep; 77(4):928-938. doi: 10.1007/s11418-023-01712-y. [PMID: 37294499]
  • Yanyan Li, Ke Yang, Linxian Zhao, Chunyi Xu, Weiling Zhou, Zhanguo Wang, Huiling Hu, Yu You. Effects of schisandra lignans on the absorption of protopanaxadiol-type ginsenosides mediated by P-glycoprotein and protopanaxatriol-type ginsenosides mediated by CYP3A4. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):117057. doi: 10.1016/j.jep.2023.117057. [PMID: 37597677]
  • Seong Jae Han, Hyemi Lee, Jiho Nam, Cheol-Ho Pan, Jimin Jeon, Siyoung Yang. Schisandra extract ameliorates arthritis pathogenesis by suppressing the NF-κB and MAPK signalling pathways. Journal of cellular and molecular medicine. 2023 Jun; ?(?):. doi: 10.1111/jcmm.17814. [PMID: 37337779]
  • Karolina Jafernik, Halina Ekiert, Agnieszka Szopa. Schisandra henryi-A Rare Species with High Medicinal Potential. Molecules (Basel, Switzerland). 2023 May; 28(11):. doi: 10.3390/molecules28114333. [PMID: 37298808]
  • Xue-Qing Liu, Xiao-Hui Yan, Jun Liang, Hai-Xue Kuang, Yong-Gang Xia. Microwave assisted free radical degradation of Schisandra polysaccharides: Optimization, identification and application. International journal of biological macromolecules. 2023 May; 237(?):124107. doi: 10.1016/j.ijbiomac.2023.124107. [PMID: 36958456]
  • Shuo Gao, Luping Sun, Xiaolu Zhou, Shuyun Zhu, Huwei Liu, Xian-En Zhao. Simultaneous and dynamic measurement of Schisandrol A changes in rat blood and brain and its comparative pharmacokinetic study in control and Parkinson's disease rats by dual-probe in vivo microdialysis. Journal of chromatography. A. 2023 Apr; 1695(?):463950. doi: 10.1016/j.chroma.2023.463950. [PMID: 37003077]
  • Xinliang Wang, Chanjuan Yang, Yi Ru, Liangqi Xie, Baoguo Xiao, Xiaoming Jin, Cungen Ma, Zhi Chai, Huijie Fan. An optimal combination of five main monomer components in Wuzi Yanzong Pill that prevents neural tube defects and reduces apoptosis and oxidative stress. Journal of ethnopharmacology. 2023 Apr; 313(?):116540. doi: 10.1016/j.jep.2023.116540. [PMID: 37088238]
  • Jana Valíčková, Štěpán Zezulka, Eliška Maršálková, Josef Kotlík, Blahoslav Maršálek, Radka Opatřilová. Bioactive compounds from Schisandra chinensis - Risk for aquatic plants?. Aquatic toxicology (Amsterdam, Netherlands). 2023 Jan; 254(?):106365. doi: 10.1016/j.aquatox.2022.106365. [PMID: 36435013]
  • Sang Ryong Kim, Hyo Jin Park, Un Ju Jung. Anti-adiposity and lipid-lowering effects of schisandrol A in diet-induced obese mice. Journal of food biochemistry. 2022 12; 46(12):e14501. doi: 10.1111/jfbc.14501. [PMID: 36332134]
  • Chaozhuang Shen, Pingping Shen, Xiaohu Wang, Xingwen Wang, Wenxin Shao, Kuo Geng, Haitang Xie. Integrating Bioinformatics and Network Pharmacology to Explore the Therapeu-tic Target and Molecular Mechanisms of Schisandrin on Hypertrophic Cardio-myopathy. Current computer-aided drug design. 2022 Nov; ?(?):. doi: 10.2174/1573409919666221124144713. [PMID: 36424782]
  • Yiwen Zhang, Saiyu Li, Panpan Yang, Qian Zhang, Huarong Xu, Kaishun Bi, Qing Li. A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154273. doi: 10.1016/j.phymed.2022.154273. [PMID: 36044818]
  • Takashi Matsumoto, Mikina Takiyama, Takumi Sakamoto, Noriko Kaifuchi, Junko Watanabe, Yutaka Takahashi, Mitsutoshi Setou. Pharmacokinetic study of Ninjin'yoeito: Absorption and brain distribution of Ninjin'yoeito ingredients in mice. Journal of ethnopharmacology. 2021 Oct; 279(?):114332. doi: 10.1016/j.jep.2021.114332. [PMID: 34129897]
  • Xiukun Lin, Rukset Attar, Iqra Mobeen, Ishmuratova Margarita Yulaevna, Aliye Aras, Ghazala Butt, Ammad Ahmad Farooqi. Regulation of cell signaling pathways by Schisandrin in different cancers: Opting for "Swiss Army Knife" instead of "Blunderbuss". Cellular and molecular biology (Noisy-le-Grand, France). 2021 Sep; 67(2):25-32. doi: 10.14715/cmb/2021.67.2.5. [PMID: 34817341]
  • Minsun Park, Kwang-Geun Lee. Effect of roasting temperature and time on volatile compounds, total polyphenols, total flavonoids, and lignan of omija (Schisandra chinensis Baillon) fruit extract. Food chemistry. 2021 Feb; 338(?):127836. doi: 10.1016/j.foodchem.2020.127836. [PMID: 32827900]
  • Su-Jin Ahn, Hyung Joo Kim, Ayoung Lee, Seung-Sik Min, Sangwhan In, Eunmi Kim. Determination of 12 herbal compounds for estimating the presence of Angelica Gigas Root, Cornus Fruit, Licorice Root, Pueraria Root, and Schisandra Fruit in foods by LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2020 Sep; 37(9):1437-1448. doi: 10.1080/19440049.2020.1778187. [PMID: 32530783]
  • Shan-Shan Guo, Xue Pang, Yang Wang, Zhu-Feng Geng, Ju-Qin Cao, Jun-Yu Liang, Zhi-Wei Deng, Shu-Shan Du. Chemical constituents isolated from stems of Schisandra chinensis and their antifeedant activity against Tribolium castaneum. Natural product research. 2020 Sep; 34(18):2595-2601. doi: 10.1080/14786419.2018.1547291. [PMID: 30623674]
  • Qiong Lai, Guang-Ying Yuan, Hao Wang, Ze-Liang Liu, Jun-Ping Kou, Bo-Yang Yu, Fang Li. Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies. Acta pharmacologica Sinica. 2020 Aug; 41(8):1058-1072. doi: 10.1038/s41401-020-0377-7. [PMID: 32123298]
  • Huimin Wu, Longfei Lin, Xueying Du, Lingling Zhang, Xingbin Yin, Xiaoxv Dong, Xiaofeng Hao, Like Xie, Changhai Qu, Jian Ni. Study on the potential effective ingredients of Xiaosheng prescription for dry eye disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Jul; 127(?):110051. doi: 10.1016/j.biopha.2020.110051. [PMID: 32428832]
  • Hui Gao, Xinya Wang, Yue Xu, Shuang Zhang. Impact of volatile oils from processed products of Schisandra chinensis fruits on a mouse model of allergic asthma. Pakistan journal of pharmaceutical sciences. 2020 Jul; 33(4):1617-1621. doi: NULL. [PMID: 33583795]
  • Yu Qi, Xinhui Cheng, Guowei Gong, Tingxu Yan, Yiyang Du, Bo Wu, Kaishun Bi, Ying Jia. Synergistic neuroprotective effect of schisandrin and nootkatone on regulating inflammation, apoptosis and autophagy via the PI3K/AKT pathway. Food & function. 2020 Mar; 11(3):2427-2438. doi: 10.1039/c9fo02927c. [PMID: 32129354]
  • Eveliina Taavitsainen, Maarit Kortesoja, Tanja Bruun, Niklas G Johansson, Leena Hanski. Assaying Chlamydia pneumoniae Persistence in Monocyte-Derived Macrophages Identifies Dibenzocyclooctadiene Lignans as Phenotypic Switchers. Molecules (Basel, Switzerland). 2020 Jan; 25(2):. doi: 10.3390/molecules25020294. [PMID: 31940776]
  • Yu Qi, Xinhui Cheng, Huiting Jing, Tingxu Yan, Feng Xiao, Bo Wu, Kaishun Bi, Ying Jia. Combination of schisandrin and nootkatone exerts neuroprotective effect in Alzheimer's disease mice model. Metabolic brain disease. 2019 12; 34(6):1689-1703. doi: 10.1007/s11011-019-00475-4. [PMID: 31422511]
  • Yiwen Zhang, Xinyan Lv, Ran Liu, Mingyang Zhang, Haopeng Liu, Hao Gao, Qian Zhang, Huarong Xu, Qing Li, Kaishun Bi. An integrated strategy for ascertaining quality marker of Schisandra chinensis (Turcz.) Baill based on correlation analysis between depression-related monoaminergic metabolites and chemical components profiling. Journal of chromatography. A. 2019 Aug; 1598(?):122-131. doi: 10.1016/j.chroma.2019.03.056. [PMID: 31047662]
  • Dong-Dong Wang, Xiao Chen, Zhi-Ping Li. Wuzhi capsule and haemoglobin influence tacrolimus elimination in paediatric kidney transplantation patients in a population pharmacokinetics analysis: A retrospective study. Journal of clinical pharmacy and therapeutics. 2019 Aug; 44(4):611-617. doi: 10.1111/jcpt.12828. [PMID: 30864229]
  • Peili Zhu, Junkui Li, Xiuqiong Fu, Zhiling Yu. Schisandra fruits for the management of drug-induced liver injury in China: A review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Jun; 59(?):152760. doi: 10.1016/j.phymed.2018.11.020. [PMID: 31004881]
  • Zhiying Ding, Jiajing Xiao, Yue Zhang, Yueyao Jiang, Weiqiang Chen, Jiahui Hu, Yu Guo, Bingren Zhang. Pharmacokinetics and liver uptake of three Schisandra lignans in rats after oral administration of liposome encapsulating β-cyclodextrin inclusion compound of Schisandra extract. Journal of liposome research. 2019 Jun; 29(2):121-132. doi: 10.1080/08982104.2018.1430830. [PMID: 30821573]
  • Toshiyuki Atsumi, Yumi Yokoyama, Takami Yokogawa, Toshiaki Makino, Isao Ohtsuka. Effects of crushed Schisandra Fruit on the content of lignans in Kampo decoction. Journal of natural medicines. 2019 Mar; 73(2):381-387. doi: 10.1007/s11418-018-1271-1. [PMID: 30535786]
  • Maarit Kortesoja, Elina Karhu, Elin Soffia Olafsdottir, Jona Freysdottir, Leena Hanski. Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells. Free radical biology & medicine. 2019 02; 131(?):309-317. doi: 10.1016/j.freeradbiomed.2018.12.019. [PMID: 30578916]
  • Zhi-Ying Zhao, Yuan-Qing Zhang, Yong-Hui Zhang, Xie-Ze Wei, He Wang, Ming Zhang, Zhan-Jun Yang, Chun-Hong Zhang. The protective underlying mechanisms of Schisandrin on SH-SY5Y cell model of Alzheimer's disease. Journal of toxicology and environmental health. Part A. 2019; 82(19):1019-1026. doi: 10.1080/15287394.2019.1684007. [PMID: 31739764]
  • Jia-Wei Wang, Feng-Yin Liang, Xiang-Shuo Ouyang, Pei-Bo Li, Zhong Pei, Wei-Wei Su. Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling. Chinese journal of natural medicines. 2018 Dec; 16(12):916-925. doi: 10.1016/s1875-5364(18)30133-x. [PMID: 30595216]
  • Seung-Hyun Jeong, Ji-Hun Jang, Seong-Ho Ham, Seung-Jeong Yang, Hea-Young Cho, Yong-Bok Lee. Simultaneous UPLC-MS/MS determination of four components of Socheongryong-tang tablet in human plasma: Application to pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Sep; 1095(?):214-225. doi: 10.1016/j.jchromb.2018.07.043. [PMID: 30081350]
  • Tao Tang, Sandong Yang, Haiqing Zhao, Yimeng Tan, Jiao Feng, Mingzhu Xia, Tong Li. [Analysis of traditional Chinese medicine components by high performance liquid chromatography with diode array detection based on double qualitative principles]. Se pu = Chinese journal of chromatography. 2018 Aug; 36(8):766-771. doi: 10.3724/sp.j.1123.2018.02012. [PMID: 30251500]
  • Ai-Hua Zhang, Jing-Bo Yu, Hui Sun, Ling Kong, Xiang-Qian Wang, Qing-Yu Zhang, Xi-Jun Wang. Identifying quality-markers from Shengmai San protects against transgenic mouse model of Alzheimer's disease using chinmedomics approach. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jun; 45(?):84-92. doi: 10.1016/j.phymed.2018.04.004. [PMID: 29685366]
  • Ajing Zhao, Li Zhang, Rong Li, Jiao Shang, Huihui Yi, Yuan Wang, Dian Zhang, Shixiang Wang, Minfeng Fang. Development and validation of an LC-MS/MS method for the simultaneous quantification of seven constituents in rat plasma and application in a pharmacokinetic study of the Zaoren Anshen prescription. Biomedical chromatography : BMC. 2018 Feb; 32(2):. doi: 10.1002/bmc.4055. [PMID: 28744886]
  • Chi-Lin Li, Yung-Yi Cheng, Chen-Hsi Hsieh, Tung-Hu Tsai. Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC-MS/MS Method. Molecules (Basel, Switzerland). 2018 Jan; 23(1):. doi: 10.3390/molecules23010173. [PMID: 29342955]
  • Fang Li, Xiao-Xue Fan, Chun Chu, Yu Zhang, Jun-Ping Kou, Bo-Yang Yu. A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 45(4):1455-1471. doi: 10.1159/000487572. [PMID: 29466787]
  • Sun-Young Nam, Kyu-Yeob Kim, Mi Hye Kim, Jae-Bum Jang, So-Young Rah, Hee Jeong Chae, Jin-Man Lee, Hyung-Min Kim, Hyun-Ja Jeong. Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan. Pharmaceutical biology. 2017 Dec; 55(1):1856-1862. doi: 10.1080/13880209.2017.1339282. [PMID: 28614972]
  • Minting Chen, Suying Wei, Chaohua Luo, Feilong Chen, Shuai Song, Qun Shen, Zhixian Mo, Fenghuan Wei. Simultaneous determination of wogonin, oroxylin a, schisandrin, paeoniflorin and emodin in rat serum by HPLC-MS/MS and application to pharmacokinetic studies. Biomedical chromatography : BMC. 2017 Oct; 31(10):. doi: 10.1002/bmc.3966. [PMID: 28236316]
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  • Xiaoyan Wu, Yuan Zhou, Fangzhou Yin, Guoliang Dai, Lin Li, Bin Xu, De Ji, Yong Sun, Chunqin Mao, Tulin Lu. Comparative pharmacokinetics and tissue distribution of schisandrin, deoxyschisandrin and schisandrin B in rats after combining acupuncture and herb medicine (schisandra chinensis). Biomedical chromatography : BMC. 2014 Aug; 28(8):1075-83. doi: 10.1002/bmc.3122. [PMID: 24474333]
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