Ketorolac (BioDeep_00000001484)
Secondary id: BioDeep_00000398435
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, tris(hydroxymethyl)aminomethane salt
化学式: C15H13NO3 (255.0895)
中文名称: 酮咯酸
谱图信息:
最多检出来源 Homo sapiens(blood) 38.62%
分子结构信息
SMILES: c1ccc(cc1)C(=O)c1ccc2C(CCn12)C(=O)O
InChI: InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
描述信息
Ketorolac is only found in individuals that have used or taken this drug. It is a pyrrolizine carboxylic acid derivative structurally related to indomethacin. It is an NSAID and is used principally for its analgesic activity (from Martindale The Extra Pharmacopoeia, 31st ed). Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) chemically related to indomethacin and tolmetin. Ketorolac tromethamine is a racemic mixture of [-]S- and [+]R-enantiomeric forms, with the S-form having analgesic activity. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis leading to decreased formation of precursors of prostaglandins and thromboxanes from arachidonic acid. The resultant reduction in prostaglandin synthesis and activity may be at least partially responsible for many of the adverse, as well as the therapeutic, effects of these medications. Analgesia is probably produced via a peripheral action in which blockade of pain impulse generation results from decreased prostaglandin activity. However, inhibition of the synthesis or actions of other substances that sensitize pain receptors to mechanical or chemical stimulation may also contribute to the analgesic effect. In terms of the ophthalmic applications of ketorolac - ocular administration of ketorolac reduces prostaglandin E2 levels in aqueous humor, secondary to inhibition of prostaglandin biosynthesis.
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BC - Antiinflammatory agents, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
14 个代谢物同义名
(±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, tris(hydroxymethyl)aminomethane salt; (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate; 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; Ketorolac (tromethamine salt); Ketorolac tromethamine; (+-)-Ketorolac; rac-Ketorolac; Ketorolacum; Ketorolaco; Ketoralac; ketorolac; Toradol; Ketorolac
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:76223
- ChEBI: CHEBI:6129
- KEGG: C07062
- KEGGdrug: D08104
- PubChem: 3826
- HMDB: HMDB0014608
- Metlin: METLIN906
- DrugBank: DB00465
- ChEMBL: CHEMBL469
- Wikipedia: Ketorolac
- MeSH: Ketorolac
- chemspider: 3694
- CAS: 74103-07-4
- CAS: 66635-83-4
- CAS: 74103-06-3
- PMhub: MS000000624
- PubChem: 9274
- NIKKAJI: J276.267F
- RefMet: Ketorolac
- KNApSAcK: 6129
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hamdy Abdelkader, Adel Al Fatease, Zeinab Fathalla. Preformulation-Assisted Design of Ketorolac Tromethamine for Effective Ophthalmic Delivery.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2023 Dec; 39(10):725-734. doi:
10.1089/jop.2023.0066. [PMID: 37676986] - Zahra Vahdat Shariatpanahi, Shaahin Shahbazi, Erfan Shahbazi. Ketorolac and Predicted Severe Acute Pancreatitis: A Randomized, Controlled Clinical Trial.
Clinical medicine & research.
2022 06; 20(2):74-80. doi:
10.3121/cmr.2021.1663. [PMID: 34996820] - Moosa Javdani, Abolfazl Barzegar, Pegah Khosravian, Mohammad Hashemnia. Evaluation of Inflammatory Response Due to Use of Controlled Release Drug Delivery System of Chitosan Hydrogel Loaded with Buprenorphine and Ketorolac in Rat with Experimental Proximal Tibial Epiphysis Defect.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2022 May; 35(5):996-1011. doi:
10.1080/08941939.2021.1989728. [PMID: 34666588] - Scott T Hall, Alicia J Mangram, Jeffrey F Barletta. Identification of Risk Factors for Acute Kidney Injury from Intravenous Ketorolac in Geriatric Trauma Patients.
World journal of surgery.
2022 01; 46(1):98-103. doi:
10.1007/s00268-021-06320-z. [PMID: 34553259] - Sri Sivalingam. SKOPE-Study of Ketorolac vs Opioid for Pain after Endoscopy: A Double-Blinded Randomized Control Trial in Patients Undergoing Ureteroscopy. Reply.
The Journal of urology.
2021 12; 206(6):1529-1530. doi:
10.1097/ju.0000000000002194. [PMID: 34431708] - Christian J F Bertens, Marlies Gijs, Aylvin A J Dias, Frank J H M van den Biggelaar, Arkasubhra Ghosh, Swaminathan Sethu, Rudy M M A Nuijts. Pharmacokinetics and efficacy of a ketorolac-loaded ocular coil in New Zealand white rabbits.
Drug delivery.
2021 Dec; 28(1):400-407. doi:
10.1080/10717544.2021.1883157. [PMID: 33594935] - Ran Yan, Xi Fu, Yi-Feng Ren, Hong Liu, Feng-Ming You, Wei Shi, Yi-Fang Jiang. The Analgesic Benefits of Ketorolac to Local Anesthetic Wound Infiltration Is Statistically Significant But Clinically Unimportant: A Comprehensive Systematic Review and Meta-Analysis.
Advances in wound care.
2021 11; 10(11):583-595. doi:
10.1089/wound.2021.0067. [PMID: 34074155] - Donald Fedrigon, Anna Faris, Naveen Kachroo, Rajat Jain, Marlie Elia, Lamont Wilkins, Jianbo Li, Smita De, Mark Noble, Manoj Monga, Sri Sivalingam. SKOPE-Study of Ketorolac vs Opioid for Pain after Endoscopy: A Double-Blinded Randomized Control Trial in Patients Undergoing Ureteroscopy.
The Journal of urology.
2021 Aug; 206(2):373-381. doi:
10.1097/ju.0000000000001772. [PMID: 33819072] - Julia Torabi, Jody M Kaban, Erin Lewis, Dana Laikhram, Rachel Simon, Skylar DeHaan, Michael Jureller, Edward Chao, Srinivas H Reddy, Melvin E Stone. Ketorolac Use for Pain Management in Trauma Patients With Rib Fractures Does not Increase of Acute Kidney Injury or Incidence of Bleeding.
The American surgeon.
2021 May; 87(5):790-795. doi:
10.1177/0003134820954835. [PMID: 33231476] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Michael E Cloesmeijer, Michiel J van Esdonk, Anne M Lynn, Anne Smits, Dick Tibboel, Youssef Daali, Klaus T Olkkola, Karel Allegaert, Paola Mian. Impact of enantiomer-specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis.
British journal of clinical pharmacology.
2021 03; 87(3):1443-1454. doi:
10.1111/bcp.14547. [PMID: 32901947] - Besma Nejim, M Libby Weaver, Satinderjit Locham, Omar Al-Nouri, Isaac N Naazie, Mahmoud B Malas. Intravenous ketorolac is associated with reduced mortality and morbidity after open abdominal aortic aneurysm repair.
Vascular.
2021 Feb; 29(1):15-26. doi:
10.1177/1708538120914454. [PMID: 32576118] - Justin Chen, David Salerno, Nadine Breslin, Tasnim Chowdhury, Steven Lobritto, Mercedes Martinez, Dana Goldner, Jennifer Vittorio. Concomitant tacrolimus and ketorolac therapy in pediatric liver transplant recipients: Teaching old dogma new tricks.
Clinical transplantation.
2021 01; 35(1):e14141. doi:
10.1111/ctr.14141. [PMID: 33145821] - Mokhtar Mabrouk, Sherin F Hammad, Aya A Abdella, Fotouh R Mansour. Chitosan-based molecular imprinted polymer for extraction and spectrophotometric determination of ketorolac in human plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Nov; 241(?):118668. doi:
10.1016/j.saa.2020.118668. [PMID: 32653823] - Héctor Isaac Rocha-González, María Elena Sánchez-Mendoza, Leticia Cruz-Antonio, Francisco Javier Flores-Murrieta, Xochilt Itzel Cornelio-Huerta, Jesús Arrieta. Antinociceptive Interaction and Pharmacokinetics of the Combination Treatments of Methyleugenol Plus Diclofenac or Ketorolac.
Molecules (Basel, Switzerland).
2020 Nov; 25(21):. doi:
10.3390/molecules25215106. [PMID: 33153182] - Shannon E Grady, Timothy B Lescun, George E Moore, Bruce R Cooper, Alec J Davern, Timothy J Brunner, Sandra D Taylor. Ketorolac Is Not More Effective Than Flunixin Meglumine or Phenylbutazone in Reducing Foot Pain in Horses.
Journal of equine veterinary science.
2020 11; 94(?):103204. doi:
10.1016/j.jevs.2020.103204. [PMID: 33077087] - Mark A Taylor, William B West, Stephen L Guthery, Mark Deneau, Scott S Short. Ketorolac after colectomy for ulcerative colitis in children: An analysis of opioid utilization and postoperative complications.
Journal of pediatric surgery.
2020 Nov; 55(11):2393-2396. doi:
10.1016/j.jpedsurg.2020.04.001. [PMID: 32402465] - M Yurashevich, C Pedro, M Fuller, A S Habib. Intra-operative ketorolac 15 mg versus 30 mg for analgesia following cesarean delivery: a retrospective study.
International journal of obstetric anesthesia.
2020 11; 44(?):116-121. doi:
10.1016/j.ijoa.2020.08.009. [PMID: 32947103] - John W Kunstman, Whitney S Brandt, Sara Abou Azar, Raymond A Jean, Ronald R Salem. Comprehensive Analysis of the Effect of Ketorolac Administration after Pancreaticoduodenectomy.
Journal of the American College of Surgeons.
2020 06; 230(6):935-942.e2. doi:
10.1016/j.jamcollsurg.2020.02.024. [PMID: 32113030] - Milad Ghani. Nanocrystalline cellulose as a biotemplate for preparation of porous titania thin film as a sorbent for thin film microextraction of ketorolac, meloxicam, diclofenac and mefenamic acid.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Apr; 1142(?):122039. doi:
10.1016/j.jchromb.2020.122039. [PMID: 32163902] - Gabrielle L Anderson, Alicia E Mattson, Caitlin S Brown, Daniel Cabrera, Kristin C Mara, M Fernanda Bellolio. Safety of parenteral ketorolac use for analgesia in geriatric emergency department patients.
The American journal of emergency medicine.
2020 04; 38(4):727-730. doi:
10.1016/j.ajem.2019.06.009. [PMID: 31201117] - Joseph A Rakowski, Robert W Holloway, Sarfraz Ahmad, Corinne N Jeppson, Jeffrey A James, Giselle B Ghurani, Glenn E Bigsby, James E Kendrick. A prospective randomized trial of intravenous ketorolac vs. acetaminophen administered with opioid patient-controlled analgesia in gynecologic surgery.
Gynecologic oncology.
2019 12; 155(3):468-472. doi:
10.1016/j.ygyno.2019.09.019. [PMID: 31601494] - David A Goldfarb. Re: Prospective, Double-Blind, Randomized Clinical Trial Comparing an ERAS Pathway with Ketorolac and Pregabalin versus Standard of Care plus Placebo during Live Donor Nephrectomy for Kidney Transplant.
The Journal of urology.
2019 12; 202(6):1087-1088. doi:
10.1097/01.ju.0000585200.72782.6a. [PMID: 31518191] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Parissa Tabrizian, Massimo Giacca, Jake Prigoff, Benjamin Tran, Matthew L Holzner, Edward Chin, Michael Palese, Daniel Herron, Antonios Arvelakis, Dianne LaPointe Rudow, Sander Florman, Ron Shapiro. Renal Safety of Intravenous Ketorolac Use After Donor Nephrectomy.
Progress in transplantation (Aliso Viejo, Calif.).
2019 09; 29(3):283-286. doi:
10.1177/1526924819855360. [PMID: 31185805] - Usha Gurunathan, Suzanne L Parker, Richard Maguire, Dale Ramdath, Manu Bijoor, Steven C Wallis, Jason A Roberts. Population Pharmacokinetics of Periarticular Ketorolac in Adult Patients Undergoing Total Hip or Total Knee Replacement Surgery.
Anesthesia and analgesia.
2019 09; 129(3):701-708. doi:
10.1213/ane.0000000000003377. [PMID: 31425209] - Abdelwahab Hashem, Fady K Ghobrial, M A Elbaset, Ahmed M Atwa, Mohamed Fadallah, Mahmoud Laymon, Ahmed El-Assmy, Khaled Z Sheir, Hassan Abol-Enein. Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial.
Investigative and clinical urology.
2019 07; 60(4):251-257. doi:
10.4111/icu.2019.60.4.251. [PMID: 31294134] - Jeffrey Campsen, Tyler Call, Chelsea McCarty Allen, Angela P Presson, Eryberto Martinez, George Rofaiel, Robin D Kim. Prospective, double-blind, randomized clinical trial comparing an ERAS pathway with ketorolac and pregabalin versus standard of care plus placebo during live donor nephrectomy for kidney transplant.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2019 06; 19(6):1777-1781. doi:
10.1111/ajt.15242. [PMID: 30589514] - Su Hwan Kim, Ki Wan Park, Jong Min Kim, Myoung Jin Ho, Hyung Tae Kim, Seh Hyon Song, Jeong Hoon Kim, Myung Joo Kang. Pharmacokinetics and four-week repeated-dose toxicity of hyaluronic acid and ketorolac combination following intra-articular administration in normal rats.
Regulatory toxicology and pharmacology : RTP.
2019 Mar; 102(?):79-89. doi:
10.1016/j.yrtph.2019.01.011. [PMID: 30611819] - Anthony J Cerreta, Chris A Masterson, Gregory A Lewbart, Delta R Dise, Mark G Papich. Pharmacokinetics of ketorolac in wild Eastern box turtles (Terrapene carolina carolina) after single intramuscular administration.
Journal of veterinary pharmacology and therapeutics.
2019 Mar; 42(2):154-159. doi:
10.1111/jvp.12733. [PMID: 30393871] - Alexander T Hawkins, Matthew D McEvoy, Jonathan P Wanderer, Molly M Ford, M Benjamin Hopkins, Roberta L Muldoon, Barbara J Martin, Adam B King, Timothy M Geiger. Ketorolac Use and Anastomotic Leak in Elective Colorectal Surgery: A Detailed Analysis.
Diseases of the colon and rectum.
2018 12; 61(12):1426-1434. doi:
10.1097/dcr.0000000000001244. [PMID: 30371548] - Amanda M Uber, Maria E Montez-Rath, David M Kwiatkowski, Catherine D Krawczeski, Scott M Sutherland. Nephrotoxin exposure and acute kidney injury in critically ill children undergoing congenital cardiac surgery.
Pediatric nephrology (Berlin, Germany).
2018 11; 33(11):2193-2199. doi:
10.1007/s00467-018-4010-7. [PMID: 29987455] - Deena D Wasserman, Derek L Isenberg. A Case of Acute Traumatic Lumbar Paraspinal Compartment Syndrome.
The Journal of emergency medicine.
2018 10; 55(4):544-546. doi:
10.1016/j.jemermed.2018.05.030. [PMID: 30037517] - Sarah Baltzley, Azzam A Malkawi, Motasem Alsmadi, Abeer M Al-Ghananeem. Sublingual spray drug delivery of ketorolac-loaded chitosan nanoparticles.
Drug development and industrial pharmacy.
2018 Sep; 44(9):1467-1472. doi:
10.1080/03639045.2018.1460378. [PMID: 29607693] - Emanuele Asti, Daniele Bernardi, Gianluca Bonitta, Luigi Bonavina. Outcomes of Transhiatal and Intercostal Pleural Drain After Ivor Lewis Esophagectomy: Comparative Analysis of Two Consecutive Patient Cohorts.
Journal of laparoendoscopic & advanced surgical techniques. Part A.
2018 May; 28(5):574-578. doi:
10.1089/lap.2018.0031. [PMID: 29620947] - James S McLay, Thomas Engelhardt, Baba S Mohammed, Gary Cameron, Mindy N Cohen, Jeffrey L Galinkin, Uwe Christians, Michael J Avram, Thomas K Henthorn, Richard M Dsida, Ahmed F Hawwa, Brian J Anderson. The pharmacokinetics of intravenous ketorolac in children aged 2 months to 16 years: A population analysis.
Paediatric anaesthesia.
2018 02; 28(2):80-86. doi:
10.1111/pan.13302. [PMID: 29266539] - Sedigheh Fekri Aval, Nosratollah Zarghami, Effat Alizadeh, Seyed Abolghasem Mohammadi. The effect of ketorolac and triamcinolone acetonide on adipogenic and hepatogenic differentiation through miRNAs 16/15/195: Possible clinical application in regenerative medicine.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):675-683. doi:
10.1016/j.biopha.2017.10.126. [PMID: 29101812] - Kuo-Sheng Liu, Wei-Hsun Chen, Cheng-Hung Lee, Yong-Fong Su, Shih-Jung Liu. Extended pain relief achieved by analgesic-eluting biodegradable nanofibers in the Nuss procedure: in vitro and in vivo studies.
International journal of nanomedicine.
2018; 13(?):8355-8364. doi:
10.2147/ijn.s189505. [PMID: 30573957] - Kay D Beharry, Charles L Cai, Gloria B Valencia, Douglas Lazzaro, Arwin M Valencia, Fabrizio Salomone, Jacob V Aranda. Human retinal endothelial cells and astrocytes cultured on 3-D scaffolds for ocular drug discovery and development.
Prostaglandins & other lipid mediators.
2018 01; 134(?):93-107. doi:
10.1016/j.prostaglandins.2017.09.005. [PMID: 28923362] - Ben H Chew, Karla A Rebullar, David Harriman, Elspeth McDougall, Ryan F Paterson, Dirk Lange. Percuflex Helical Ureteral Stents Significantly Reduce Patient Analgesic Requirements Compared to Control Stents.
Journal of endourology.
2017 Dec; 31(12):1321-1325. doi:
10.1089/end.2017.0349. [PMID: 29048209] - Karla Lyzet Beltrán-Villalobos, Myrna Déciga-Campos, Hidemi Aguilar-Mariscal, María Eva González-Trujano, María Fernanda Martínez-Salazar, María de Los Ángeles Ramírez-Cisneros, María Yolanda Rios, Francisco Javier López-Muñoz. Synergistic antinociceptive interaction of Syzygium aromaticum or Rosmarinus officinalis coadministered with ketorolac in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Oct; 94(?):858-864. doi:
10.1016/j.biopha.2017.07.166. [PMID: 28802239] - Kazuhiro Takahashi, Anita K Patel, Shunji Nagai, Mohamed Safwan, Krishna G Putchakayala, William J Kane, Lauren E Malinzak, Jason E Denny, Atsushi Yoshida, Dean Y Kim. Perioperative Ketorolac Use: A Potential Risk Factor for Renal Dysfunction After Live-Donor Nephrectomy.
Annals of transplantation.
2017 Sep; 22(?):563-569. doi:
10.12659/aot.904762. [PMID: 28924138] - Sujatha Baddam, Inmaculada Aban, Lee Hilliard, Thomas Howard, David Askenazi, Jeffrey D Lebensburger. Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis.
Pediatric nephrology (Berlin, Germany).
2017 Aug; 32(8):1451-1456. doi:
10.1007/s00467-017-3623-6. [PMID: 28238158] - Jacqueline J Eastman, Kellen J Cavagnero, Adam S Deconde, Alex S Kim, Maya R Karta, David H Broide, Bruce L Zuraw, Andrew A White, Sandra C Christiansen, Taylor A Doherty. Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease.
The Journal of allergy and clinical immunology.
2017 Jul; 140(1):101-108.e3. doi:
10.1016/j.jaci.2016.11.023. [PMID: 28279492] - Aida Kulo, Anne Smits, Sanita Maleškić, Marc Van de Velde, Kristel Van Calsteren, Jan De Hoon, Rene Verbesselt, Jan Deprest, Karel Allegaert. Enantiomer-specific ketorolac pharmacokinetics in young women, including pregnancy and postpartum period.
Bosnian journal of basic medical sciences.
2017 Feb; 17(1):54-60. doi:
10.17305/bjbms.2016.1515. [PMID: 27968707] - Binh Cao Quan Nguyen, Hideaki Takahashi, Yoshihiro Uto, M D Shahinozzaman, Shinkichi Tawata, Hiroshi Maruta. 1,2,3-Triazolyl ester of Ketorolac: A "Click Chemistry"-based highly potent PAK1-blocking cancer-killer.
European journal of medicinal chemistry.
2017 Jan; 126(?):270-276. doi:
10.1016/j.ejmech.2016.11.038. [PMID: 27889630] - Benjamin Maslin, Lawrence Lipana, Brandon Roth, Gopal Kodumudi, Nalini Vadivelu. Safety Considerations in the Use of Ketorolac for Postoperative Pain.
Current drug safety.
2017; 12(1):67-73. doi:
10.2174/1574886311666160719154420. [PMID: 27440142] - Manohar Lal, Ravi Bhushan. Analytical and semi-preparative enantioresolution of (RS)-ketorolac from pharmaceutical formulation and in human plasma by HPLC.
Biomedical chromatography : BMC.
2016 Oct; 30(10):1526-34. doi:
10.1002/bmc.3716. [PMID: 26988799] - Fatin Affas. Local infiltration analgesia in knee and hip arthroplasty efficacy and safety.
Scandinavian journal of pain.
2016 10; 13(?):59-66. doi:
10.1016/j.sjpain.2016.05.041. [PMID: 28850535] - M Galar-Martínez, S García-Medina, L M Gómez-Olivan, I Pérez-Coyotl, D J Mendoza-Monroy, R E Arrazola-Morgain. Oxidative stress and genotoxicity induced by ketorolac on the common carp Cyprinus carpio.
Environmental toxicology.
2016 Sep; 31(9):1035-43. doi:
10.1002/tox.22113. [PMID: 25899151] - H J Park, K Sandor, J McQueen, S A Woller, C I Svensson, M Corr, T L Yaksh. The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation.
European journal of pain (London, England).
2016 07; 20(6):917-25. doi:
10.1002/ejp.816. [PMID: 26517300] - Lucian C Warth, Nicolas O Noiseux, Matthew H Hogue, Alison L Klaassen, Steve S Liu, John J Callaghan. Risk of Acute Kidney Injury After Primary and Revision Total Hip Arthroplasty and Total Knee Arthroplasty Using a Multimodal Approach to Perioperative Pain Control Including Ketorolac and Celecoxib.
The Journal of arthroplasty.
2016 Jan; 31(1):253-5. doi:
10.1016/j.arth.2015.08.012. [PMID: 26377377] - Lyndsi K Meyenburg, Andrew J Crannage, Julie A Murphy, Matthew J Korobey. Evaluation of a Pharmacy-Managed Pharmacokinetic Dosing Program.
Journal of pharmacy practice.
2015 Dec; 28(6):529-34. doi:
10.1177/0897190014544825. [PMID: 25107423] - S K Dubey, A Anand, R N Saha. Enantioselective Tissue Distribution of Ketorolac and its Enantiomers in Rats.
Drug research.
2015 Aug; 65(8):428-31. doi:
10.1055/s-0034-1389913. [PMID: 25350079] - Ahmed H Abdelazeem, Shabana I Khan, Stephen W White, Kenneth J Sufka, Christopher R McCurdy. Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.
Bioorganic & medicinal chemistry.
2015 Jul; 23(13):3248-59. doi:
10.1016/j.bmc.2015.04.057. [PMID: 25975638] - R Villa, G Ravasio, C Ferraresi, A Zonca, S Carli, L Borghi, P Cagnardi. Pharmacokinetics of intravenous ketorolac in cats undergoing gonadectomy.
New Zealand veterinary journal.
2015 May; 63(3):162-6. doi:
10.1080/00480169.2014.987329. [PMID: 25523103] - Mahasen A Radwan, Amal El Sayeh F Abou El Ela, Maha A Hassan, Dalia A El-Maraghy. Pharmacokinetics and analgesic effect of ketorolac floating delivery system.
Drug delivery.
2015 May; 22(3):320-7. doi:
10.3109/10717544.2014.883189. [PMID: 24512312] - M V Baranov, A S Kovalev, D F Perfilov, R V Chernogorov, L G Repenkova. [Influence of simulated microgravity on the threshold of pain sensitivity in humans with single dose of ketorolac].
Patologicheskaia fiziologiia i eksperimental'naia terapiia.
2015 Apr; 59(2):23-8. doi:
NULL. [PMID: 26571803] - Neill Y Li, Liping Tong, Andrew S Barbas, Syamal D Bhattacharya, Philip Y Wai, Paul C Kuo. Renal response following perioperative ketorolac analgesia in living kidney donation.
Transplantation.
2015 Mar; 99(3):e22-3. doi:
10.1097/tp.0000000000000597. [PMID: 25695791] - Hadir M Maher, Shorog M Al-Taweel, Mona M Alshehri, Nourah Z Alzoman. Novel stereoselective high-performance liquid chromatographic method for simultaneous determination of guaifenesin and ketorolac enantiomers in human plasma.
Chirality.
2014 Oct; 26(10):629-39. doi:
10.1002/chir.22354. [PMID: 25043279] - F Affas, S Eksborg, P Wretenberg, C Olofsson, N Stephanson, C-O Stiller. Plasma concentration of ketorolac after local infiltration analgesia in hip arthroplasty.
Acta anaesthesiologica Scandinavica.
2014 Oct; 58(9):1140-5. doi:
10.1111/aas.12371. [PMID: 25078268] - Gwen M Grimsby, Paul E Andrews, Erik P Castle, Rafael Nunez, Laurie A Mihalik, Yu-Hui H Chang, Mitchell R Humphreys. Long-term renal function after donor nephrectomy: secondary follow-up analysis of the randomized trial of ketorolac vs placebo.
Urology.
2014 Jul; 84(1):78-81. doi:
10.1016/j.urology.2014.04.009. [PMID: 24976224] - Iu I Hubs'kyĭ, T A Bukhtiarova, H H Horiushko, N V Litvinova, H I Paramonova, T M Kurapova, O M Velychko, L P Babenko. [Biophysical parameters of erythrocyte membranes and mechanisms of interaction with non-opioid analgesics under acute pain syndrome].
Ukrainian biochemical journal.
2014 May; 86(3):98-106. doi:
". [PMID: 25033559] - Lisa Oliveri, Katie Jerzewski, Alexander Kulik. Black box warning: is ketorolac safe for use after cardiac surgery?.
Journal of cardiothoracic and vascular anesthesia.
2014 Apr; 28(2):274-9. doi:
10.1053/j.jvca.2013.07.014. [PMID: 24231193] - Yifan Yang, Jason B Young, Carol R Schermer, Garth H Utter. Use of ketorolac is associated with decreased pneumonia following rib fractures.
American journal of surgery.
2014 Apr; 207(4):566-72. doi:
10.1016/j.amjsurg.2013.05.011. [PMID: 24112670] - Nicholas A Williams, Jenna L Bowen, Ghaith Al-Jayyoussi, Mark Gumbleton, Chris J Allender, Jamie Li, Tim Harrah, Aditya Raja, Hrishi B Joshi. An ex vivo investigation into the transurothelial permeability and bladder wall distribution of the nonsteroidal anti-inflammatory ketorolac.
Molecular pharmaceutics.
2014 Mar; 11(3):673-82. doi:
10.1021/mp400274z. [PMID: 24460452] - Kuo-Sheng Liu, Pei-Wen Hsieh, Ibrahim A Aljuffali, Yin-Ku Lin, Shu-Hao Chang, Jhi-Joung Wang, Jia-You Fang. Impact of ester promoieties on transdermal delivery of ketorolac.
Journal of pharmaceutical sciences.
2014 Mar; 103(3):974-86. doi:
10.1002/jps.23888. [PMID: 24481782] - Taís Gratieri, Ester Pujol-Bello, Guilherme M Gelfuso, Joel G de Souza, Renata F V Lopez, Yogeshvar N Kalia. Iontophoretic transport kinetics of ketorolac in vitro and in vivo: demonstrating local enhanced topical drug delivery to muscle.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2014 Feb; 86(2):219-26. doi:
10.1016/j.ejpb.2013.06.009. [PMID: 23791718] - P Cagnardi, A Zonca, M Gallo, R Villa, S Carli, M Beccaglia, D Fonda, G Ravasio. Pharmacokinetics and perioperative efficacy of intravenous ketorolac in dogs.
Journal of veterinary pharmacology and therapeutics.
2013 Dec; 36(6):603-8. doi:
10.1111/jvp.12044. [PMID: 23473380] - Patrice Forget, Jean-Pascal Machiels, Pierre G Coulie, Martine Berliere, Alain J Poncelet, Bertrand Tombal, Annabelle Stainier, Catherine Legrand, Jean-Luc Canon, Yann Kremer, Marc De Kock. Neutrophil:lymphocyte ratio and intraoperative use of ketorolac or diclofenac are prognostic factors in different cohorts of patients undergoing breast, lung, and kidney cancer surgery.
Annals of surgical oncology.
2013 Dec; 20 Suppl 3(?):S650-60. doi:
10.1245/s10434-013-3136-x. [PMID: 23884751] - Baba S Mohammed, Thomas Engelhardt, Gary A Cameron, Ahmed F Hawwa, Peter J Helms, James S McLay. Development of an enantiomer selective microsampling assay for the quantification of ketorolac suitable for paediatric pharmacokinetic studies.
Biopharmaceutics & drug disposition.
2013 Oct; 34(7):377-86. doi:
10.1002/bdd.1852. [PMID: 24251328] - Brady S Moffett, Antonio Cabrera. Ketorolac-associated renal morbidity: risk factors in cardiac surgical infants.
Cardiology in the young.
2013 Oct; 23(5):752-4. doi:
10.1017/s1047951112001680. [PMID: 23088994] - H O Ammar, M Ghorab, A A Mahmoud, T S Makram, A M Ghoneim. Rapid pain relief using transdermal film forming polymeric solution of ketorolac.
Pharmaceutical development and technology.
2013 Sep; 18(5):1005-16. doi:
10.3109/10837450.2011.627867. [PMID: 22191998] - Alia A Badawi, Hanan M El-Laithy, Demiana I Nesseem, Shereen S El-Husseney. Pharmaceutical and medical aspects of hyaluronic acid-ketorolac combination therapy in osteoarthritis treatment: radiographic imaging and bone mineral density.
Journal of drug targeting.
2013 Jul; 21(6):551-63. doi:
10.3109/1061186x.2013.776054. [PMID: 23697583] - Silke Hirsch, Laura Corradini, Stefan Just, Kirsten Arndt, Henri Doods. The CGRP receptor antagonist BIBN4096BS peripherally alleviates inflammatory pain in rats.
Pain.
2013 May; 154(5):700-707. doi:
10.1016/j.pain.2013.01.002. [PMID: 23473785] - Augustus D Mazzocca, Mary Beth R McCarthy, Jessica Intravia, Knut Beitzel, John Apostolakos, Mark P Cote, James Bradley, Robert A Arciero. An in vitro evaluation of the anti-inflammatory effects of platelet-rich plasma, ketorolac, and methylprednisolone.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.
2013 Apr; 29(4):675-83. doi:
10.1016/j.arthro.2012.12.005. [PMID: 23395471] - Maria Kollinius-Bringland, Fatin Affas, Per Wretenberg. [Acute renal failure after local infiltration anesthesia. Two cases related to orthopedic surgery described].
Lakartidningen.
2013 Feb; 110(6):284-5. doi:
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Drug research.
2013 Jan; 63(1):34-7. doi:
10.1055/s-0032-1331693. [PMID: 23447046] - B Raju, M Ramesh, Roshan M Borkar, Raju Padiya, Sanjay K Banerjee, R Srinivas. Development and validation of liquid chromatography-mass spectrometric method for simultaneous determination of moxifloxacin and ketorolac in rat plasma: application to pharmacokinetic study.
Biomedical chromatography : BMC.
2012 Nov; 26(11):1341-7. doi:
10.1002/bmc.2701. [PMID: 22334358] - Meizi Wang, Wu Liu, Qingjun Lu, Huiyang Zeng, Sumeng Liu, Yankun Yue, Haiting Cheng, Ying Liu, Ming Xue. Pharmacokinetic comparison of ketorolac after intracameral, intravitreal, and suprachoroidal administration in rabbits.
Retina (Philadelphia, Pa.).
2012 Nov; 32(10):2158-64. doi:
10.1097/iae.0b013e3182576d1d. [PMID: 23099451] - A Kulo, M van de Velde, K van Calsteren, A Smits, J de Hoon, R Verbesselt, J Deprest, K Allegaert. Pharmacokinetics of intravenous ketorolac following caesarean delivery.
International journal of obstetric anesthesia.
2012 Oct; 21(4):334-8. doi:
10.1016/j.ijoa.2012.06.001. [PMID: 22901775] - Maria Lodise, Fabio De-Giorgio, Riccardo Rossi, Ernesto d'Aloja, Nadia Fucci. Acute Ibuprofen intoxication: report on a case and review of the literature.
The American journal of forensic medicine and pathology.
2012 Sep; 33(3):242-6. doi:
10.1097/paf.0b013e318253d6ff. [PMID: 22835967] - Jean-Philippe Lafrance, Donald R Miller. Dispensed selective and nonselective nonsteroidal anti-inflammatory drugs and the risk of moderate to severe hyperkalemia: a nested case-control study.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2012 Jul; 60(1):82-9. doi:
10.1053/j.ajkd.2012.02.328. [PMID: 22503390] - Gregory A Sawyer, Brett C Anderson, Neha P Raukar, Paul D Fadale. Intramuscular ketorolac injections in the athlete.
Sports health.
2012 Jul; 4(4):319-27. doi:
10.1177/1941738112439686. [PMID: 23016103] - B Raju, M Ramesh, Roshan M Borkar, Raju Padiya, Sanjay K Banerjee, R Srinivas. Identification and structural characterization of in vivo metabolites of ketorolac using liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS).
Journal of mass spectrometry : JMS.
2012 Jul; 47(7):919-31. doi:
10.1002/jms.3043. [PMID: 22791260] - R Rikalainen-Salmi, J G Förster, K Mäkelä, P Virolainen, K A Leino, M T Pitkänen, P J Neuvonen, K S Kuusniemi. Local infiltration analgesia with levobupivacaine compared with intrathecal morphine in total hip arthroplasty patients.
Acta anaesthesiologica Scandinavica.
2012 Jul; 56(6):695-705. doi:
10.1111/j.1399-6576.2012.02667.x. [PMID: 22404241] - Ana Laura Martínez, María Eva González-Trujano, Marco Chávez, Francisco Pellicer. Antinociceptive effectiveness of triterpenes from rosemary in visceral nociception.
Journal of ethnopharmacology.
2012 Jun; 142(1):28-34. doi:
10.1016/j.jep.2012.03.052. [PMID: 22543174] - Steven M Selbst. Pediatric emergency medicine: legal briefs.
Pediatric emergency care.
2012 Jun; 28(6):577-80. doi:
10.1097/pec.0b013e31825995da. [PMID: 22668666] - David R Drover, Gregory B Hammer, Brian J Anderson. The pharmacokinetics of ketorolac after single postoperative intranasal administration in adolescent patients.
Anesthesia and analgesia.
2012 Jun; 114(6):1270-6. doi:
10.1213/ane.0b013e31824f92c2. [PMID: 22467894] - Juan Antonio López-Villodres, José Pedro De La Cruz, Javier Muñoz-Marin, Ana Guerrero, José Julio Reyes, José Antonio González-Correa. Cytoprotective effect of nonsteroidal antiinflammatory drugs in rat brain slices subjected to reoxygenation after oxygen-glucose deprivation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 Apr; 45(5):624-31. doi:
10.1016/j.ejps.2012.01.001. [PMID: 22245539] - Jin Wook Kim, Du Geon Moon, Jung Ho Shin, Jae Hyun Bae, Jeong Gu Lee, Mi Mi Oh. Predictors of Voiding Dysfunction after Mid-urethral Sling Surgery for Stress Urinary Incontinence.
International neurourology journal.
2012 Mar; 16(1):30-6. doi:
10.5213/inj.2012.16.1.30. [PMID: 22500251] - Howard S Smith, Bryan Voss. Pharmacokinetics of intravenous ibuprofen: implications of time of infusion in the treatment of pain and fever.
Drugs.
2012 Feb; 72(3):327-37. doi:
10.2165/11599230-000000000-00000. [PMID: 22316349] - Woon-Seok Kang, Sung-Yun Kim, Jong-Chan Son, Ju-Deok Kim, Hasmizy Bin Muhammad, Seong-Hyop Kim, Tae-Gyoon Yoon, Tae-Yop Kim. The effect of dexmedetomidine on the adjuvant propofol requirement and intraoperative hemodynamics during remifentanil-based anesthesia.
Korean journal of anesthesiology.
2012 Feb; 62(2):113-8. doi:
10.4097/kjae.2012.62.2.113. [PMID: 22379564] - David Tonoli, Emmanuel Varesio, Gérard Hopfgartner. Mass spectrometric QUAL/QUAN approaches for drug metabolism and metabolomics.
Chimia.
2012; 66(4):218-22. doi:
10.2533/chimia.2012.218. [PMID: 22613154] - N N Pshenkina. [Influence of Perftoran nanoemulsion on blood plasma concentrations of lipophilic drugs].
Eksperimental'naia i klinicheskaia farmakologiia.
2012; 75(2):30-4. doi:
NULL. [PMID: 22550857] - Evren H Gokce, Emrah Korkmaz, Eleonora Dellera, Giuseppina Sandri, M Cristina Bonferoni, Ozgen Ozer. Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications.
International journal of nanomedicine.
2012; 7(?):1841-50. doi:
10.2147/ijn.s29710. [PMID: 22605933] - Xu Tao, Peng Jing-Bo, Zhang Wen-Tong, Zhao Xin, Zhang Tao-Tao, Yang Shi-Jun, Fang Lei, Zou Zhong-Mei, Cai Da-Yong. Antiatherogenic and Anti-Ischemic Properties of Traditional Chinese Medicine Xinkeshu via Endothelial Protecting Function.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):302137. doi:
10.1155/2012/302137. [PMID: 22007259] - Sergio D Bergese, Sonia Ramamoorthy, Gary Patou, Kenneth Bramlett, Stephen R Gorfine, Keith A Candiotti. Efficacy profile of liposome bupivacaine, a novel formulation of bupivacaine for postsurgical analgesia.
Journal of pain research.
2012; 5(?):107-16. doi:
10.2147/jpr.s30861. [PMID: 22570563] - Kuntheavy Ing Lorenzini, Marie Besson, Youssef Daali, Denis Salomon, Pierre Dayer, Jules Desmeules. A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination.
Basic & clinical pharmacology & toxicology.
2011 Nov; 109(5):357-64. doi:
10.1111/j.1742-7843.2011.00733.x. [PMID: 21615691]
