Hydrochlorothiazide (BioDeep_00000001476)

 

Secondary id: BioDeep_00000229719, BioDeep_00000397911

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

化学式: C7H8ClN3O4S2 (296.9645)
中文名称: 氢氯噻嗪
谱图信息: 最多检出来源 Homo sapiens(feces) 91.1%

分子结构信息

SMILES: c1c(c(cc2c1NCNS2(=O)=O)S(=O)(=O)N)Cl
InChI: InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

描述信息

Hydrochlorothiazide is a thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. -- Pubchem. Hydrochlorothiazide (Apo-Hydro, Aquazide H, Microzide, Oretic), sometimes abbreviated HCT, HCTZ, or HZT is a popular diuretic drug that acts by inhibiting the kidneys ability to retain water. This reduces the volume of the blood, decreasing peripheral vascular resistance. Chlorothiazide, a carbonic anhydrase inhibitor. --Wikipedia.
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. -- Pubchem
CONFIDENCE standard compound; INTERNAL_ID 514; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2043; ORIGINAL_PRECURSOR_SCAN_NO 2040
CONFIDENCE standard compound; INTERNAL_ID 514; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2023; ORIGINAL_PRECURSOR_SCAN_NO 2022
CONFIDENCE standard compound; INTERNAL_ID 514; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2034; ORIGINAL_PRECURSOR_SCAN_NO 2032
CONFIDENCE standard compound; INTERNAL_ID 514; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2037; ORIGINAL_PRECURSOR_SCAN_NO 2035
CONFIDENCE standard compound; INTERNAL_ID 514; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2060; ORIGINAL_PRECURSOR_SCAN_NO 2058
CONFIDENCE standard compound; INTERNAL_ID 514; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2039; ORIGINAL_PRECURSOR_SCAN_NO 2037
C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators

同义名列表

95 个代谢物同义名

6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide; Chlorsulfonamidodihydrobenzothiadiazine dioxide; Hydrochlorothiazide intensol; 3,4-Dihydrochlorothiazide; Dihydroxychlorothiazidum; Dihydrochlorothiazidum; Dihydrochlorothiazide; Hydrochlorothiazidum; Hydrochloro thiazide; Dihydrochlorothiazid; hydrochlorothiazide; Hydrochlorthiazide; Hydrochlorothiazid; Hidroclorotiazida; Dihydrochlorurite; Hidrochlortiazid; Dihydrochlorurit; Chlorosulthiadil; Dichlothiazide; chlorothiazide; Hydrodiuretic; Lopressor HCT; Hydrosaluric; Ro-hydrazide; Dichlotiazid; Hidrotiazida; Hydro-diuril; Lotensin HCT; Hypothiazide; Servithiazid; Hydro-aquil; Dichlorosal; Idrotiazide; Hypothiazid; Hydrodiuril; Aldactazide; Dichlotride; Hidroronol; Neo-codema; Hydrothide; Diclotride; Megadiuril; Sectrazide; Apresazide; Jen-diril; Thiuretic; Thlaretic; Hydropres; Chlorzide; Moduretic; Disalunil; Neoflumen; Thiaretic; Microzide; Aquarills; Ser-ap-es; Urodiazin; Vaseretic; Newtolide; Hydrozide; Acuretic; Prinzide; Maschitt; Aquarius; Vetidrex; Capozide; Inderide; Caplaril; Timolide; Aldoril; Unipres; Panurin; Maxzide; Hydro-D; Ivaugan; Dyazide; Esidrex; Esidrix; Hydril; Hidril; Bremil; Cidrex; Diuril; Fluvin; Nefrix; Oretic; Esimil; Hyzaar; Drenol; Direma; Zide; Ziac; HCTZ; HCZ; Hydrochlorothiazide



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ACE, ADD1, ALB, CAT, EGFR, MME, NR3C2
Golgi apparatus, trans-Golgi network membrane 1 AQP2
Peripheral membrane protein 1 ADD1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 EGFR, NR3C2
Nucleus 4 ADD1, ALB, EGFR, NR3C2
cytosol 5 ADD1, ALB, AVP, CAT, NR3C2
dendrite 2 AVP, MME
nuclear body 1 ADD1
trans-Golgi network 1 MME
centrosome 1 ALB
nucleoplasm 3 ADD1, NR3C2, SCNN1G
Cell membrane 9 ACE, ADD1, AGTR1, AGTR2, AQP2, EGFR, KIT, MME, SLC26A4
Cytoplasmic side 1 ADD1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 6 AGTR1, AGTR2, AQP2, CACNA1I, SCNN1G, SLC26A4
Synapse 2 ADD1, MME
cell junction 1 EGFR
cell surface 2 EGFR, MME
glutamatergic synapse 1 EGFR
Golgi apparatus 2 ALB, AQP2
Golgi membrane 2 EGFR, INS
neuronal cell body 1 MME
synaptic vesicle 1 MME
Lysosome 1 ACE
Presynapse 1 MME
acrosomal vesicle 1 KIT
endosome 2 ACE, EGFR
plasma membrane 13 ACE, ADD1, AGTR1, AGTR2, AQP2, CACNA1I, EGFR, KIT, KNG1, MME, REN, SCNN1G, SLC26A4
Membrane 10 ACE, AGTR1, AQP2, CACNA1I, CAT, EGFR, KIT, MME, REN, SLC26A4
apical plasma membrane 4 AQP2, EGFR, SCNN1G, SLC26A4
axon 1 MME
basolateral plasma membrane 2 AQP2, EGFR
brush border 1 MME
extracellular exosome 8 ACE, ALB, AQP2, CAT, KNG1, MME, SCNN1G, SLC26A4
endoplasmic reticulum 1 ALB
extracellular space 10 ACE, ALB, AVP, CRP, EGFR, INS, KIT, KNG1, PTH, REN
perinuclear region of cytoplasm 2 AQP2, EGFR
adherens junction 1 ADD1
mitochondrion 1 CAT
protein-containing complex 3 ALB, CAT, EGFR
intracellular membrane-bounded organelle 1 CAT
postsynaptic density 1 ADD1
Single-pass type I membrane protein 3 ACE, EGFR, KIT
Secreted 6 ACE, ALB, AVP, CRP, INS, REN
extracellular region 9 ACE, ALB, AVP, CAT, CRP, INS, KNG1, PTH, REN
cytoplasmic side of plasma membrane 1 KIT
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
nuclear membrane 1 EGFR
external side of plasma membrane 3 ACE, KIT, SCNN1G
cytoplasmic vesicle 1 MME
Early endosome 1 MME
apical part of cell 1 REN
cell-cell junction 1 KIT
recycling endosome 1 AQP2
Single-pass type II membrane protein 1 MME
Apical cell membrane 3 AQP2, SCNN1G, SLC26A4
Membrane raft 2 EGFR, MME
Cytoplasm, cytoskeleton 1 ADD1
focal adhesion 4 ADD1, CAT, EGFR, MME
Peroxisome 1 CAT
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 KNG1
secretory granule 1 AVP
lateral plasma membrane 1 AQP2
receptor complex 3 EGFR, KIT, NR3C2
ciliary basal body 1 ALB
chromatin 1 NR3C2
cytoskeleton 1 ADD1
centriole 1 ALB
Secreted, extracellular space 1 KNG1
brush border membrane 2 ACE, SLC26A4
spindle pole 1 ALB
blood microparticle 2 ALB, KNG1
sperm midpiece 1 ACE
Basolateral cell membrane 1 AQP2
fibrillar center 1 KIT
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 AQP2
sodium channel complex 1 SCNN1G
basal plasma membrane 2 ACE, EGFR
[Isoform 3]: Cytoplasm 1 KIT
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
secretory granule membrane 1 MME
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, INS, KNG1
platelet alpha granule lumen 2 ALB, KNG1
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 AVP
clathrin-coated endocytic vesicle membrane 2 AVP, EGFR
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transport vesicle membrane 1 AQP2
catalase complex 1 CAT
neuron projection terminus 1 MME
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
F-actin capping protein complex 1 ADD1
lumenal side of membrane 1 AQP2
ciliary transition fiber 1 ALB


文献列表

  • Qi-Fang Huang, Di Zhang, Yihong Luo, Kun Hu, Qiong Wu, Hailong Qiu, Fei Xu, Mei-Ling Wang, Xin Chen, Yan Li, Ji-Guang Wang. Comparison of two single-pill dual combination antihypertensive therapies in Chinese patients: a randomized, controlled trial. BMC medicine. 2024 01; 22(1):28. doi: 10.1186/s12916-023-03244-4. [PMID: 38263021]
  • H He, Y Sui, X Yu, G Luo, J Xue, W Yang, Y Long. Potential low toxic alternative for Na-Cl cotransporter inhibition: A diuretic effect and mechanism study of Pyrrosia petiolosa. Annales pharmaceutiques francaises. 2024 Jan; 82(1):44-52. doi: 10.1016/j.pharma.2023.07.002. [PMID: 37422255]
  • Aozi Feng, Weizhao Lin, Li Li, Mengnan Zeng, Jun Lyu. Pharmacoeconomic evaluation of stroke and myocardial infarction prevention in hypertensive patients: Markov model based on the ACCOMPLISH trial. The Journal of international medical research. 2023 Dec; 51(12):3000605231214921. doi: 10.1177/03000605231214921. [PMID: 38114070]
  • Meriem Kemel, Asma Lahouel, Djamila Zama, Samir Benayache, Fadila Benayache. Evaluation of anti-inflammatory, diuretic and oral glucose tolerance activities of phenolic compound-rich fractions of Hammada articulata in Albino Wistar rats. Fitoterapia. 2023 Mar; 167(?):105477. doi: 10.1016/j.fitote.2023.105477. [PMID: 37004275]
  • Patrícia Regina Terço Leite, Bethânia Rosa Lorençone, Karyne Garcia Tafarelo Moreno, Katiana Simões Lopes, Aline Aparecida Macedo Marques, Clara Soligo Fortini, Rhanany Alan Calloi Palozi, Mariana Dalmagro, Cândida Aparecida Leite Kassuya, Ariany Carvalho Dos Santos, Marcos José Salvador, Arquimedes Gasparotto Junior. The NO-cGMP-K+ Channel Pathway Participates in Diuretic and Cardioprotective Effects of Blutaparon portulacoides in Spontaneously Hypertensive Rats. Planta medica. 2022 Oct; 88(13):1152-1162. doi: 10.1055/a-1690-3566. [PMID: 35299274]
  • Luísa Nathália Bolda Mariano, Daiane Aline Pontioli, Ana Aline da Silva, Rivaldo Niero, Valdir Cechinel-Filho, Priscila de Souza. Diuretic and Antiurolithic Effect of Garcinia humilis (Vahl) C.D. Adams Leaves, a Medicinal Plant Native to South American Countries. Chemistry & biodiversity. 2022 Oct; 19(10):e202200022. doi: 10.1002/cbdv.202200022. [PMID: 35997661]
  • J M Llamas-Molina, F J Navarro-Triviño, R Ruiz-Villaverde. What Dermatologists Should Know About Thiazides. Actas dermo-sifiliograficas. 2022 May; 113(5):498-504. doi: 10.1016/j.ad.2021.12.015. [PMID: 35697409]
  • Gustavo A Yerino, Ethel C Feleder, Emilia K Halabe, Liliana Diaz, Mario Sakson, Mariana Iglesias, Tobías Haddad, Emilio Roldán, Nélida Mondelo. Pharmacokinetics of a new fixed-dose combination of candesartan cilexetil, hydrochlorothiazide, and rosuvastatin in healthy adult subjects. International journal of clinical pharmacology and therapeutics. 2022 Apr; 60(4):192-206. doi: 10.5414/cp204026. [PMID: 35103587]
  • Bart J Kramers, Iris W Koorevaar, Maatje D A van Gastel, Harry van Goor, Kenneth R Hallows, Hiddo L Heerspink, Hui Li, Wouter N Leonhard, Dorien J M Peters, Jiedong Qiu, Daan J Touw, Ron T Gansevoort, Esther Meijer. Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial. Clinical journal of the American Society of Nephrology : CJASN. 2022 04; 17(4):507-517. doi: 10.2215/cjn.11260821. [PMID: 35314480]
  • Chin-Chou Huang, Yi-Long Huang, Chao-Hsiung Lin, Jaw-Wen Chen. Plasma metabolomic profiles associated with hypertension and blood pressure in response to thiazide diuretics. Hypertension research : official journal of the Japanese Society of Hypertension. 2022 03; 45(3):464-473. doi: 10.1038/s41440-021-00825-9. [PMID: 34952949]
  • Jacob K Meariman, Jane C Sutphen, Juan Gao, Daniel R Kapusta. Nalfurafine, a G-Protein-Biased KOR (Kappa Opioid Receptor) Agonist, Enhances the Diuretic Response and Limits Electrolyte Losses to Standard-of-Care Diuretics. Hypertension (Dallas, Tex. : 1979). 2022 02; 79(2):379-390. doi: 10.1161/hypertensionaha.121.18503. [PMID: 34852633]
  • Fumihiko Takeuchi, Yi-Qiang Liang, Masato Isono, Mia Yang Ang, Kotaro Mori, Norihiro Kato. Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration. Hypertension (Dallas, Tex. : 1979). 2022 02; 79(2):413-423. doi: 10.1161/hypertensionaha.121.18026. [PMID: 34879704]
  • Di Zhang, Qi-Fang Huang, Yan Li, Ji-Guang Wang. Incident hyperuricemia in relation to antihypertensive therapy with the irbesartan/hydrochlorothiazide combination. Blood pressure monitoring. 2021 Dec; 26(6):413-418. doi: 10.1097/mbp.0000000000000554. [PMID: 34128490]
  • Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi, Xinling Liang. The effect of amiloride in decreasing albuminuria in patients with diabetic kidney diseases: a prospective, crossover, open-label study. Renal failure. 2021 Dec; 43(1):452-459. doi: 10.1080/0886022x.2021.1892759. [PMID: 33657976]
  • Jing de Haan-Du, Gijs W D Landman, Klaas H Groenier, Pauline A J Vissers, Marieke W J Louwman, Nanne Kleefstra, Geertruida H de Bock. The Risk of Cutaneous Squamous Cell Carcinoma Among Patients with Type 2 Diabetes Receiving Hydrochlorothiazide: A Cohort Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2021 11; 30(11):2114-2121. doi: 10.1158/1055-9965.epi-21-0620. [PMID: 34493493]
  • Cedric Edwards, Gregory L Hundemer, William Petrcich, Mark Canney, Greg Knoll, Kevin Burns, Ann Bugeja, Manish M Sood. Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function. JAMA network open. 2021 09; 4(9):e2123365. doi: 10.1001/jamanetworkopen.2021.23365. [PMID: 34524440]
  • Vahid Solak, Mehmet İlker Gökce, Önder Yaman. Potassium citrate vs. hydrochlorothiazide to reduce urinary calcium excretion in calcium oxalate stone patients with hypercalciuria: a prospective randomized study. International urology and nephrology. 2021 Sep; 53(9):1791-1796. doi: 10.1007/s11255-021-02879-7. [PMID: 33904027]
  • Yannick Marc, Reda Hmazzou, Nadia De Mota, Fabrice Balavoine, Catherine Llorens-Cortes. Effects of firibastat in combination with enalapril and hydrochlorothiazide on blood pressure and vasopressin release in hypertensive DOCA-salt rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Aug; 140(?):111682. doi: 10.1016/j.biopha.2021.111682. [PMID: 34020248]
  • Orlando Salinas-Jaramillo, Alejandra Monroy-Arreola, Sebastian Herrera-Noreña, Ana L Guzmán-Ortiz, Abrahan Hernández-Hernández, Silvia Méndez-Flores, Judith Domínguez-Cherit, Noe V Duran-Figueroa, Dean J Naisbitt, Pedro Cortes-Reynosa, Eduardo Perez Salazar, Héctor Quezada, J Luis Castrejón-Flores. Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions. Chemical research in toxicology. 2021 07; 34(7):1738-1748. doi: 10.1021/acs.chemrestox.1c00047. [PMID: 34142820]
  • Yubing Ji, Chunyang Kang, Jiajun Chen, Lei Zhang. Identification of p.Arg205Cys in CASR in an autosomal dominant hypocalcaemia type 1 pedigree: A case report. Medicine. 2021 Jun; 100(25):e26443. doi: 10.1097/md.0000000000026443. [PMID: 34160437]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Lei-Xiao Hu, Dian Wang, Hua-Ling Liu, Qing-Tao Zhang, Dong-Sheng Sun, Li Zhang, Xin Chen, Gui-Li Chang, Ji-Guang Wang. A double-blind, placebo-controlled trial on the antihypertensive treatment effect of a quadruple single-pill combination. Journal of clinical hypertension (Greenwich, Conn.). 2021 04; 23(4):815-822. doi: 10.1111/jch.14207. [PMID: 33548084]
  • Sarah Jane Commander, Huali Wu, Felix Boakye-Agyeman, Chiara Melloni, Chi Dang Hornik, Kanecia Zimmerman, Amira Al-Uzri, Susan R Mendley, Barrie Harper, Michael Cohen-Wolkowiez, Christoph P Hornik. Pharmacokinetics of Hydrochlorothiazide in Children: A Potential Surrogate for Renal Secretion Maturation. Journal of clinical pharmacology. 2021 03; 61(3):368-377. doi: 10.1002/jcph.1739. [PMID: 33029806]
  • Karlo Filipovic, Barbara Bellmann, Arian Sultan, Jakob LÜker, Tobias Plenge, Daniel Steven. Hydrochlorothiazide therapy: impact on early recurrence of atrial fibrillation after catheter ablation?. Minerva cardiology and angiology. 2021 02; 69(1):102-108. doi: 10.23736/s2724-5683.20.05170-1. [PMID: 32989962]
  • Elisabetta Bigagli, Lorenzo Cinci, Mario D'Ambrosio, Patrizia Nardini, Francesca Portelli, Roberta Colucci, Maura Lodovici, Alessandro Mugelli, Cristina Luceri. Hydrochlorothiazide Use and Risk of Nonmelanoma Skin Cancers: A Biological Plausibility Study. Oxidative medicine and cellular longevity. 2021; 2021(?):6655542. doi: 10.1155/2021/6655542. [PMID: 34434485]
  • Akshay Athavale, Jack Morris, Meg Jardine, Martin Gallagher, Shaundeep Sen, Angus Ritchie, Amanda Y Wang. Acute interstitial nephritis and nephrogenic diabetes insipidus following treatment with sulfamethoxazole-trimethoprim and temozolomide. Nephrology (Carlton, Vic.). 2021 Jan; 26(1):12-14. doi: 10.1111/nep.13783. [PMID: 32935422]
  • Eline H Groenland, Monique E A M van Kleef, Michiel L Bots, Frank L J Visseren, Kim C M van der Elst, Wilko Spiering. Plasma Trough Concentrations of Antihypertensive Drugs for the Assessment of Treatment Adherence: A Meta-Analysis. Hypertension (Dallas, Tex. : 1979). 2021 01; 77(1):85-93. doi: 10.1161/hypertensionaha.120.16061. [PMID: 33249865]
  • Thibault Letellier, Florent Le Borgne, Clarisse Kerleau, Aurélie Gaultier, Jacques Dantal, Simon Ville. Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients. Clinical journal of the American Society of Nephrology : CJASN. 2020 12; 15(12):1804-1813. doi: 10.2215/cjn.02560220. [PMID: 33172936]
  • Kevin Stritt, Piet Bosshard, Olivier Bonny, Beat Roth. [Prevention of nephrolithiasis - Preliminary results of the Swiss Kidney Stone Cohort (SKSC) and the NOSTONE trial]. Revue medicale suisse. 2020 Dec; 16(717):2317-2320. doi: NULL. [PMID: 33263954]
  • Mohammad Abdul-Azim Mohammad, Marianne Alphonse Mahrouse, Enas Abdel Hakeem Amer, Nouran Saleh Elharati. Validated LC-MS/MS method for the simultaneous determination of enalapril maleate, nitrendipine, hydrochlorothiazide, and their major metabolites in human plasma. Biomedical chromatography : BMC. 2020 Dec; 34(12):e4955. doi: 10.1002/bmc.4955. [PMID: 32706446]
  • Javed Shaikh Afzal Shaikh, Santosh Raut, Ahad Abdul, Mohd Arif Ali Khan Pathan. High performance liquid chromatographic assay of amlodipine, valsartan and hydrochlorothiazide simultaneously and its application to pharmaceuticals, urine and plasma analysis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Oct; 1155(?):122295. doi: 10.1016/j.jchromb.2020.122295. [PMID: 32771968]
  • Luísa Nathália Bolda Mariano, Thaise Boeing, Valdir Cechinel-Filho, Rivaldo Niero, Luisa Mota da Silva, Priscila de Souza. The acute diuretic effects with low-doses of natural prenylated xanthones in rats. European journal of pharmacology. 2020 Oct; 884(?):173432. doi: 10.1016/j.ejphar.2020.173432. [PMID: 32745607]
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