hydrochlorothiazide (BioDeep_00000397911)
Main id: BioDeep_00000229719
natural product Volatile Flavor Compounds
代谢物信息卡片
hydrochlorothiazide
化学式: C7H8ClN3O4S2 (296.9644758)
中文名称: 氢氯噻嗪, 氢氯噻嗪-d2
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: c1c(c(cc2c1NCNS2(=O)=O)S(=O)(=O)N)Cl
InChI: InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
描述信息
C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators
CONFIDENCE Reference Standard (Level 1)
同义名列表
2 个代谢物同义名
数据库引用编号
32 个数据库交叉引用编号
- ChEBI: CHEBI:5778
- KEGG: C07041
- KEGGdrug: D00340
- PubChem: 3639
- DrugBank: DB00999
- ChEMBL: CHEMBL435
- MeSH: Hydrochlorothiazide
- CAS: 1190006-03-1
- CAS: 125727-50-6
- CAS: 8049-49-8
- CAS: 58-93-5
- CAS: 1219798-89-6
- MoNA: VF-NPL-QTOF008001
- MoNA: VF-NPL-QTOF008000
- MoNA: VF-NPL-QTOF007999
- MoNA: WA000339
- MoNA: WA000338
- MoNA: WA000337
- MoNA: WA000336
- MoNA: WA000335
- MoNA: VF-NPL-LTQ000484
- MoNA: VF-NPL-LTQ000483
- MoNA: HMDB0001928_ms_ms_1864
- MoNA: HMDB0001928_ms_ms_1865
- MoNA: HMDB0001928_ms_ms_1863
- MoNA: TUE00377
- MoNA: TUE00376
- MoNA: TUE00375
- PubChem: 9253
- PDB-CCD: HCZ
- RefMet: Hydrochlorothiazide
- KNApSAcK: 5778
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qi-Fang Huang, Di Zhang, Yihong Luo, Kun Hu, Qiong Wu, Hailong Qiu, Fei Xu, Mei-Ling Wang, Xin Chen, Yan Li, Ji-Guang Wang. Comparison of two single-pill dual combination antihypertensive therapies in Chinese patients: a randomized, controlled trial.
BMC medicine.
2024 01; 22(1):28. doi:
10.1186/s12916-023-03244-4. [PMID: 38263021] - H He, Y Sui, X Yu, G Luo, J Xue, W Yang, Y Long. Potential low toxic alternative for Na-Cl cotransporter inhibition: A diuretic effect and mechanism study of Pyrrosia petiolosa.
Annales pharmaceutiques francaises.
2024 Jan; 82(1):44-52. doi:
10.1016/j.pharma.2023.07.002. [PMID: 37422255] - Aozi Feng, Weizhao Lin, Li Li, Mengnan Zeng, Jun Lyu. Pharmacoeconomic evaluation of stroke and myocardial infarction prevention in hypertensive patients: Markov model based on the ACCOMPLISH trial.
The Journal of international medical research.
2023 Dec; 51(12):3000605231214921. doi:
10.1177/03000605231214921. [PMID: 38114070] - Meriem Kemel, Asma Lahouel, Djamila Zama, Samir Benayache, Fadila Benayache. Evaluation of anti-inflammatory, diuretic and oral glucose tolerance activities of phenolic compound-rich fractions of Hammada articulata in Albino Wistar rats.
Fitoterapia.
2023 Mar; 167(?):105477. doi:
10.1016/j.fitote.2023.105477. [PMID: 37004275] - Patrícia Regina Terço Leite, Bethânia Rosa Lorençone, Karyne Garcia Tafarelo Moreno, Katiana Simões Lopes, Aline Aparecida Macedo Marques, Clara Soligo Fortini, Rhanany Alan Calloi Palozi, Mariana Dalmagro, Cândida Aparecida Leite Kassuya, Ariany Carvalho Dos Santos, Marcos José Salvador, Arquimedes Gasparotto Junior. The NO-cGMP-K+ Channel Pathway Participates in Diuretic and Cardioprotective Effects of Blutaparon portulacoides in Spontaneously Hypertensive Rats.
Planta medica.
2022 Oct; 88(13):1152-1162. doi:
10.1055/a-1690-3566. [PMID: 35299274] - Luísa Nathália Bolda Mariano, Daiane Aline Pontioli, Ana Aline da Silva, Rivaldo Niero, Valdir Cechinel-Filho, Priscila de Souza. Diuretic and Antiurolithic Effect of Garcinia humilis (Vahl) C.D. Adams Leaves, a Medicinal Plant Native to South American Countries.
Chemistry & biodiversity.
2022 Oct; 19(10):e202200022. doi:
10.1002/cbdv.202200022. [PMID: 35997661] - J M Llamas-Molina, F J Navarro-Triviño, R Ruiz-Villaverde. What Dermatologists Should Know About Thiazides.
Actas dermo-sifiliograficas.
2022 May; 113(5):498-504. doi:
10.1016/j.ad.2021.12.015. [PMID: 35697409] - Gustavo A Yerino, Ethel C Feleder, Emilia K Halabe, Liliana Diaz, Mario Sakson, Mariana Iglesias, Tobías Haddad, Emilio Roldán, Nélida Mondelo. Pharmacokinetics of a new fixed-dose combination of candesartan cilexetil, hydrochlorothiazide, and rosuvastatin in healthy adult subjects.
International journal of clinical pharmacology and therapeutics.
2022 Apr; 60(4):192-206. doi:
10.5414/cp204026. [PMID: 35103587] - Bart J Kramers, Iris W Koorevaar, Maatje D A van Gastel, Harry van Goor, Kenneth R Hallows, Hiddo L Heerspink, Hui Li, Wouter N Leonhard, Dorien J M Peters, Jiedong Qiu, Daan J Touw, Ron T Gansevoort, Esther Meijer. Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial.
Clinical journal of the American Society of Nephrology : CJASN.
2022 04; 17(4):507-517. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2022 03; 45(3):464-473. doi:
10.1038/s41440-021-00825-9. [PMID: 34952949] - Jacob K Meariman, Jane C Sutphen, Juan Gao, Daniel R Kapusta. Nalfurafine, a G-Protein-Biased KOR (Kappa Opioid Receptor) Agonist, Enhances the Diuretic Response and Limits Electrolyte Losses to Standard-of-Care Diuretics.
Hypertension (Dallas, Tex. : 1979).
2022 02; 79(2):379-390. doi:
10.1161/hypertensionaha.121.18503. [PMID: 34852633] - Fumihiko Takeuchi, Yi-Qiang Liang, Masato Isono, Mia Yang Ang, Kotaro Mori, Norihiro Kato. Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration.
Hypertension (Dallas, Tex. : 1979).
2022 02; 79(2):413-423. doi:
10.1161/hypertensionaha.121.18026. [PMID: 34879704] - Di Zhang, Qi-Fang Huang, Yan Li, Ji-Guang Wang. Incident hyperuricemia in relation to antihypertensive therapy with the irbesartan/hydrochlorothiazide combination.
Blood pressure monitoring.
2021 Dec; 26(6):413-418. doi:
10.1097/mbp.0000000000000554. [PMID: 34128490] - Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi, Xinling Liang. The effect of amiloride in decreasing albuminuria in patients with diabetic kidney diseases: a prospective, crossover, open-label study.
Renal failure.
2021 Dec; 43(1):452-459. doi:
10.1080/0886022x.2021.1892759. [PMID: 33657976] - Jing de Haan-Du, Gijs W D Landman, Klaas H Groenier, Pauline A J Vissers, Marieke W J Louwman, Nanne Kleefstra, Geertruida H de Bock. The Risk of Cutaneous Squamous Cell Carcinoma Among Patients with Type 2 Diabetes Receiving Hydrochlorothiazide: A Cohort Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2021 11; 30(11):2114-2121. doi:
10.1158/1055-9965.epi-21-0620. [PMID: 34493493] - Cedric Edwards, Gregory L Hundemer, William Petrcich, Mark Canney, Greg Knoll, Kevin Burns, Ann Bugeja, Manish M Sood. Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function.
JAMA network open.
2021 09; 4(9):e2123365. doi:
10.1001/jamanetworkopen.2021.23365. [PMID: 34524440] - Vahid Solak, Mehmet İlker Gökce, Önder Yaman. Potassium citrate vs. hydrochlorothiazide to reduce urinary calcium excretion in calcium oxalate stone patients with hypercalciuria: a prospective randomized study.
International urology and nephrology.
2021 Sep; 53(9):1791-1796. doi:
10.1007/s11255-021-02879-7. [PMID: 33904027] - Yannick Marc, Reda Hmazzou, Nadia De Mota, Fabrice Balavoine, Catherine Llorens-Cortes. Effects of firibastat in combination with enalapril and hydrochlorothiazide on blood pressure and vasopressin release in hypertensive DOCA-salt rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Aug; 140(?):111682. doi:
10.1016/j.biopha.2021.111682. [PMID: 34020248] - Orlando Salinas-Jaramillo, Alejandra Monroy-Arreola, Sebastian Herrera-Noreña, Ana L Guzmán-Ortiz, Abrahan Hernández-Hernández, Silvia Méndez-Flores, Judith Domínguez-Cherit, Noe V Duran-Figueroa, Dean J Naisbitt, Pedro Cortes-Reynosa, Eduardo Perez Salazar, Héctor Quezada, J Luis Castrejón-Flores. Extracellular Vesicles from Human Plasma Show a Distinctive Proteome and miRNome Profile in Patients with Severe Cutaneous Adverse Reactions.
Chemical research in toxicology.
2021 07; 34(7):1738-1748. doi:
10.1021/acs.chemrestox.1c00047. [PMID: 34142820] - Yubing Ji, Chunyang Kang, Jiajun Chen, Lei Zhang. Identification of p.Arg205Cys in CASR in an autosomal dominant hypocalcaemia type 1 pedigree: A case report.
Medicine.
2021 Jun; 100(25):e26443. doi:
10.1097/md.0000000000026443. [PMID: 34160437] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Lei-Xiao Hu, Dian Wang, Hua-Ling Liu, Qing-Tao Zhang, Dong-Sheng Sun, Li Zhang, Xin Chen, Gui-Li Chang, Ji-Guang Wang. A double-blind, placebo-controlled trial on the antihypertensive treatment effect of a quadruple single-pill combination.
Journal of clinical hypertension (Greenwich, Conn.).
2021 04; 23(4):815-822. doi:
10.1111/jch.14207. [PMID: 33548084] - Sarah Jane Commander, Huali Wu, Felix Boakye-Agyeman, Chiara Melloni, Chi Dang Hornik, Kanecia Zimmerman, Amira Al-Uzri, Susan R Mendley, Barrie Harper, Michael Cohen-Wolkowiez, Christoph P Hornik. Pharmacokinetics of Hydrochlorothiazide in Children: A Potential Surrogate for Renal Secretion Maturation.
Journal of clinical pharmacology.
2021 03; 61(3):368-377. doi:
10.1002/jcph.1739. [PMID: 33029806] - Karlo Filipovic, Barbara Bellmann, Arian Sultan, Jakob LÜker, Tobias Plenge, Daniel Steven. Hydrochlorothiazide therapy: impact on early recurrence of atrial fibrillation after catheter ablation?.
Minerva cardiology and angiology.
2021 02; 69(1):102-108. doi:
10.23736/s2724-5683.20.05170-1. [PMID: 32989962] - Elisabetta Bigagli, Lorenzo Cinci, Mario D'Ambrosio, Patrizia Nardini, Francesca Portelli, Roberta Colucci, Maura Lodovici, Alessandro Mugelli, Cristina Luceri. Hydrochlorothiazide Use and Risk of Nonmelanoma Skin Cancers: A Biological Plausibility Study.
Oxidative medicine and cellular longevity.
2021; 2021(?):6655542. doi:
10.1155/2021/6655542. [PMID: 34434485] - Akshay Athavale, Jack Morris, Meg Jardine, Martin Gallagher, Shaundeep Sen, Angus Ritchie, Amanda Y Wang. Acute interstitial nephritis and nephrogenic diabetes insipidus following treatment with sulfamethoxazole-trimethoprim and temozolomide.
Nephrology (Carlton, Vic.).
2021 Jan; 26(1):12-14. doi:
10.1111/nep.13783. [PMID: 32935422] - Eline H Groenland, Monique E A M van Kleef, Michiel L Bots, Frank L J Visseren, Kim C M van der Elst, Wilko Spiering. Plasma Trough Concentrations of Antihypertensive Drugs for the Assessment of Treatment Adherence: A Meta-Analysis.
Hypertension (Dallas, Tex. : 1979).
2021 01; 77(1):85-93. doi:
10.1161/hypertensionaha.120.16061. [PMID: 33249865] - Thibault Letellier, Florent Le Borgne, Clarisse Kerleau, Aurélie Gaultier, Jacques Dantal, Simon Ville. Association between Use of Hydrochlorothiazide and Risk of Keratinocyte Cancers in Kidney Transplant Recipients.
Clinical journal of the American Society of Nephrology : CJASN.
2020 12; 15(12):1804-1813. doi:
10.2215/cjn.02560220. [PMID: 33172936] - Kevin Stritt, Piet Bosshard, Olivier Bonny, Beat Roth. [Prevention of nephrolithiasis - Preliminary results of the Swiss Kidney Stone Cohort (SKSC) and the NOSTONE trial].
Revue medicale suisse.
2020 Dec; 16(717):2317-2320. doi:
NULL. [PMID: 33263954] - Mohammad Abdul-Azim Mohammad, Marianne Alphonse Mahrouse, Enas Abdel Hakeem Amer, Nouran Saleh Elharati. Validated LC-MS/MS method for the simultaneous determination of enalapril maleate, nitrendipine, hydrochlorothiazide, and their major metabolites in human plasma.
Biomedical chromatography : BMC.
2020 Dec; 34(12):e4955. doi:
10.1002/bmc.4955. [PMID: 32706446] - Javed Shaikh Afzal Shaikh, Santosh Raut, Ahad Abdul, Mohd Arif Ali Khan Pathan. High performance liquid chromatographic assay of amlodipine, valsartan and hydrochlorothiazide simultaneously and its application to pharmaceuticals, urine and plasma analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Oct; 1155(?):122295. doi:
10.1016/j.jchromb.2020.122295. [PMID: 32771968] - Luísa Nathália Bolda Mariano, Thaise Boeing, Valdir Cechinel-Filho, Rivaldo Niero, Luisa Mota da Silva, Priscila de Souza. The acute diuretic effects with low-doses of natural prenylated xanthones in rats.
European journal of pharmacology.
2020 Oct; 884(?):173432. doi:
10.1016/j.ejphar.2020.173432. [PMID: 32745607] - Pravallika Chadalavada, C Roberto Simons-Linares, Prabhleen Chahal. Drug-induced acute pancreatitis: Prevalence, Causative agents, and Outcomes.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2020 Oct; 20(7):1281-1286. doi:
10.1016/j.pan.2020.07.401. [PMID: 32878711] - Sung-Ji Park, Si Jae Rhee. Real-World Effectiveness and Safety of a Single-Pill Combination of Olmesartan/Amlodipine/Hydrochlorothiazide in Korean Patients with Essential Hypertension (RESOLVE): A Large, Observational, Retrospective, Cohort Study.
Advances in therapy.
2020 08; 37(8):3500-3514. doi:
10.1007/s12325-020-01404-z. [PMID: 32557349] - Kelly S Galhardo, Tony R L Dadamos, Ricardo J N Bettencourt da Silva, Sergio A S Machado. Development and validation of an advanced electrochemical sensor for the fast and cheap determination of hydrochlorothiazide in urine samples using the Monte-Carlo method for uncertainty evaluation.
Talanta.
2020 Aug; 215(?):120883. doi:
10.1016/j.talanta.2020.120883. [PMID: 32312432] - Marika Ruponen, Henna Rusanen, Riikka Laitinen. Dissolution and Permeability Properties of Co-Amorphous Formulations of Hydrochlorothiazide.
Journal of pharmaceutical sciences.
2020 07; 109(7):2252-2261. doi:
10.1016/j.xphs.2020.04.008. [PMID: 32315662] - Camile Cecconi Cechinel-Zanchett, Luísa Nathália Bolda Mariano, Thaise Boeing, Juliana de Carvalho da Costa, Luísa Mota Da Silva, Jairo K Bastos, Valdir Cechinel-Filho, Priscila de Souza. Diuretic and Renal Protective Effect of Kaempferol 3-O-Alpha-l-rhamnoside (Afzelin) in Normotensive and Hypertensive Rats.
Journal of natural products.
2020 06; 83(6):1980-1989. doi:
10.1021/acs.jnatprod.0c00274. [PMID: 32453565] - Zeid A ALOthman, Khalid M Alsheetan, Hassan Y Aboul-Enein, Imran Ali. Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jun; 1146(?):122125. doi:
10.1016/j.jchromb.2020.122125. [PMID: 32371329] - Simonetta Bossoni, Laura Chiesa, Andrea Giustina. Severe hypocalcemia in a thyroidectomized woman with Covid-19 infection.
Endocrine.
2020 May; 68(2):253-254. doi:
10.1007/s12020-020-02326-0. [PMID: 32346814] - George Hripcsak, Marc A Suchard, Steven Shea, RuiJun Chen, Seng Chan You, Nicole Pratt, David Madigan, Harlan M Krumholz, Patrick B Ryan, Martijn J Schuemie. Comparison of Cardiovascular and Safety Outcomes of Chlorthalidone vs Hydrochlorothiazide to Treat Hypertension.
JAMA internal medicine.
2020 04; 180(4):542-551. doi:
10.1001/jamainternmed.2019.7454. [PMID: 32065600] - Dominique M Bovée, Wesley J Visser, Igor Middel, Anneke De Mik-van Egmond, Rick Greupink, Rosalinde Masereeuw, Frans G M Russel, A H Jan Danser, Robert Zietse, Ewout J Hoorn. A Randomized Trial of Distal Diuretics versus Dietary Sodium Restriction for Hypertension in Chronic Kidney Disease.
Journal of the American Society of Nephrology : JASN.
2020 03; 31(3):650-662. doi:
10.1681/asn.2019090905. [PMID: 31996411] - Miao Ye, Wen Xu, Da-Qing He, Xian Wu, Wen-Fang Lai, Xiao-Qin Zhang, Yu Lin, Wei Xu, Xu-Wen Li. Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis.
Journal of natural products.
2020 02; 83(2):362-373. doi:
10.1021/acs.jnatprod.9b00857. [PMID: 32031812] - Wen'ge Huang, Yingzhuo Yang, Wen Wen, Yu Luo, Jiasi Wu, Li Xiang, Yinfan Hu, Shijun Xu, Simin Chen, Ping Wang. Vanillin enhances the passive transport rate and absorption of drugs with moderate oral bioavailability in vitro and in vivo by affecting the membrane structure.
Food & function.
2020 Jan; 11(1):700-710. doi:
10.1039/c9fo02846c. [PMID: 31909774] - Sarah Ahmad, Muhammad Jamshaid, Rizwan Mehmood, Irfan Bashir, Rabia Ali, Sana Jameel. Blend of guar gum and Eudragit shows excellent drug release retarding behavior in sustained release tablets.
Pakistan journal of pharmaceutical sciences.
2020 Jan; 33(1):71-77. doi:
". [PMID: 32122833] - Adrielli Tenfen, Luísa Nathália Bolda Mariano, Thaise Boeing, Camile Cecconi Cechinel-Zanchett, Luisa Mota da Silva, Sérgio Faloni de Andrade, Priscila de Souza, Valdir Cechinel-Filho. Effects of myricetin-3-O-α-rhamnoside (myricitrin) treatment on urinary parameters of Wistar rats.
The Journal of pharmacy and pharmacology.
2019 Dec; 71(12):1832-1838. doi:
10.1111/jphp.13172. [PMID: 31588559] - Amal S M Gad El-Hak, Ahmed A K Mohammed, Ahmed F Abdel Hakiem, Refaat M Mahfouz. Molecular conformation, vibrational spectroscopic and NBO analysis of atenolol and atenolol-hydrochlorothiazide cocrystals.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Nov; 222(?):117200. doi:
10.1016/j.saa.2019.117200. [PMID: 31176161] - Stela Dineva, Katya Uzunova, Velichka Pavlova, Elena Filipova, Krassimir Kalinov, Toni Vekov. Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis.
Journal of human hypertension.
2019 11; 33(11):766-774. doi:
10.1038/s41371-019-0255-2. [PMID: 31595024] - Seol Ju Moon, Ji-Young Jeon, Kyung-Sang Yu, Min-Gul Kim. Pharmacokinetic Interaction Among Telmisartan, Amlodipine, and Hydrochlorothiazide After a Single Oral Administration in Healthy Male Subjects.
Clinical therapeutics.
2019 11; 41(11):2273-2282. doi:
10.1016/j.clinthera.2019.08.020. [PMID: 31564513] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Anna Solini, Marta Seghieri, Livia Giannini, Edoardo Biancalana, Federico Parolini, Chiara Rossi, Angela Dardano, Stefano Taddei, Lorenzo Ghiadoni, Rosa Maria Bruno. The Effects of Dapagliflozin on Systemic and Renal Vascular Function Display an Epigenetic Signature.
The Journal of clinical endocrinology and metabolism.
2019 10; 104(10):4253-4263. doi:
10.1210/jc.2019-00706. [PMID: 31162549] - Jing Li, Shuhua Xu, Lei Yang, Janey Yang, Claire J Wang, Alan M Weinstein, Lawrence G Palmer, Tong Wang. Sex difference in kidney electrolyte transport II: impact of K+ intake on thiazide-sensitive cation excretion in male and female mice.
American journal of physiology. Renal physiology.
2019 10; 317(4):F967-F977. doi:
10.1152/ajprenal.00125.2019. [PMID: 31390232] - Jia Yin, David J Wagner, Bhagwat Prasad, Nina Isoherranen, Kenneth E Thummel, Joanne Wang. Renal secretion of hydrochlorothiazide involves organic anion transporter 1/3, organic cation transporter 2, and multidrug and toxin extrusion protein 2-K.
American journal of physiology. Renal physiology.
2019 10; 317(4):F805-F814. doi:
10.1152/ajprenal.00141.2019. [PMID: 31322418] - Anna Posadzy-Malaczynska, Katarzyna Rajpold, Lucyna Woznicka-Leskiewicz, Justyna Marcinkowska. Reversal of an unfavorable effect of hydrochlorothiazide compared to angiotensin converting enzyme inhibitor on serum uric acid and oxypurine levels by estrogen-progestin therapy in hypertensive postmenopausal women.
Current medical research and opinion.
2019 10; 35(10):1687-1697. doi:
10.1080/03007995.2019.1612656. [PMID: 31033362] - Luísa Nathália Bolda Mariano, Thaise Boeing, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Valdir Cechinel-Filho, Rivaldo Niero, Luisa Mota da Silva, Priscila de Souza, Sergio Faloni de Andrade. 1,3,5,6-Tetrahydroxyxanthone, a natural xanthone, induces diuresis and saluresis in normotensive and hypertensive rats.
Chemico-biological interactions.
2019 Sep; 311(?):108778. doi:
10.1016/j.cbi.2019.108778. [PMID: 31377058] - S Heleen Binnenmars, Eva Corpeleijn, Arjan J Kwakernaak, Daan J Touw, Ido P Kema, Gozewijn D Laverman, Stephan J L Bakker, Gerjan Navis. Impact of Moderate Sodium Restriction and Hydrochlorothiazide on Iodine Excretion in Diabetic Kidney Disease: Data from a Randomized Cross-Over Trial.
Nutrients.
2019 Sep; 11(9):. doi:
10.3390/nu11092204. [PMID: 31547438] - Michelle R Cunha, Ana R Cunha, Bianca C A A Marques, Samanta S Mattos, Jenifer D'El-Rei, Natalia M França, Wille Oigman, Mario F Neves. Association of urinary sodium/potassium ratio with structural and functional vascular changes in non-diabetic hypertensive patients.
Journal of clinical hypertension (Greenwich, Conn.).
2019 09; 21(9):1360-1369. doi:
10.1111/jch.13660. [PMID: 31444860] - Adrian Dobrowolski, Ramona Strob, Jan Felix Dräger-Gillessen, Damian Pieloth, Gerhard Schaldach, Helmut Wiggers, Markus Thommes. Preparation of submicron drug particles via spray drying from organic solvents.
International journal of pharmaceutics.
2019 Aug; 567(?):118501. doi:
10.1016/j.ijpharm.2019.118501. [PMID: 31288055] - Peng Fan, Yu-Mo Zhao, Di Zhang, Ying Liao, Kun-Qi Yang, Tao Tian, Ying Lou, Fang Luo, Wen-Jun Ma, Hui-Min Zhang, Lei Song, Jun Cai, Ya-Xin Liu, Xian-Liang Zhou. A Novel Frameshift Mutation of SCNN1G Causing Liddle Syndrome with Normokalemia.
American journal of hypertension.
2019 07; 32(8):752-758. doi:
10.1093/ajh/hpz053. [PMID: 30977777] - Dor Golomb, Amihay Nevo, Hanan Goldberg, Yaron Ehrlich, David Margel, David Lifshitz. Long-Term Adherence to Medications in Secondary Prevention of Urinary Tract Stones.
Journal of endourology.
2019 06; 33(6):469-474. doi:
10.1089/end.2019.0040. [PMID: 30909741] - Prem Pais, Hyejung Jung, Antonio Dans, Jun Zhu, Lisheng Liu, Deepak Kamath, Jackie Bosch, Eva Lonn, Salim Yusuf. Impact of blood pressure lowering, cholesterol lowering and their combination in Asians and non-Asians in those without cardiovascular disease: an analysis of the HOPE 3 study.
European journal of preventive cardiology.
2019 05; 26(7):681-697. doi:
10.1177/2047487318819019. [PMID: 30537846] - Clintoria R Williams, Monisha Mistry, Aswathy M Cheriyan, Jasmine M Williams, Meagan K Naraine, Carla L Ellis, Rickta Mallick, Abinash C Mistry, Jennifer L Gooch, Benjamin Ko, Hui Cai, Robert S Hoover. Zinc deficiency induces hypertension by promoting renal Na+ reabsorption.
American journal of physiology. Renal physiology.
2019 04; 316(4):F646-F653. doi:
10.1152/ajprenal.00487.2018. [PMID: 30649891] - Anyi Wang, Takuo Hirose, Yusuke Ohsaki, Chika Takahashi, Emiko Sato, Ikuko Oba-Yabana, Satoshi Kinugasa, Yoshikazu Muroya, Sadayoshi Ito, Takefumi Mori. Hydrochlorothiazide ameliorates polyuria caused by tolvaptan treatment of polycystic kidney disease in PCK rats.
Clinical and experimental nephrology.
2019 Apr; 23(4):455-464. doi:
10.1007/s10157-018-1669-9. [PMID: 30426292] - Jackie Bosch, Martin O'Donnell, Balakumar Swaminathan, Eva Marie Lonn, Mikul Sharma, Gilles Dagenais, Rafael Diaz, Kamlesh Khunti, Basil S Lewis, Alvaro Avezum, Claes Held, Matyas Keltai, Christopher Reid, William D Toff, Antonio Dans, Lawrence A Leiter, Karen Sliwa, Shun Fu Lee, Janice M Pogue, Robert Hart, Salim Yusuf. Effects of blood pressure and lipid lowering on cognition: Results from the HOPE-3 study.
Neurology.
2019 03; 92(13):e1435-e1446. doi:
10.1212/wnl.0000000000007174. [PMID: 30814321] - Donata Favretto, Sindi Visentin, Salvatore Scrivano, Emanuele Roselli, Fabio Mattiazzi, Roberto Pertile, Susanna Vogliardi, Marianna Tucci, Massimo Montisci. Multiple incidence of the prescription diuretic hydrochlorothiazide in compounded nutritional supplements.
Drug testing and analysis.
2019 Mar; 11(3):512-522. doi:
10.1002/dta.2499. [PMID: 30194914] - Jan-Ole Johannsen, Hannes Reuter, Fabian Hoffmann, Cornelia Blaich, Martin H J Wiesen, Thomas Streichert, Carsten Müller. Reliable and easy-to-use LC-MS/MS-method for simultaneous determination of the antihypertensives metoprolol, amlodipine, canrenone and hydrochlorothiazide in patients with therapy-refractory arterial hypertension.
Journal of pharmaceutical and biomedical analysis.
2019 Feb; 164(?):373-381. doi:
10.1016/j.jpba.2018.11.002. [PMID: 30439665] - Fatemeh Balaei, Sirous Ghobadi. Hydrochlorothiazide binding to human serum albumin induces some compactness in the molecular structure of the protein: A multi-spectroscopic and computational study.
Journal of pharmaceutical and biomedical analysis.
2019 Jan; 162(?):1-8. doi:
10.1016/j.jpba.2018.09.009. [PMID: 30218717] - Stefano Omboni, Claudio Borghi. Efficacy of Zofenopril Alone or in Combination with Hydrochlorothiazide in Patients with Kidney Dysfunction.
Current clinical pharmacology.
2019; 14(1):5-15. doi:
10.2174/1574884713666181025145404. [PMID: 30360726] - Gui-Yun Jiang, Qun Li, Yun-Xiang Lv. Short-term treatment of irbesartan and hydrochlorothiazide decreases plasma N-terminal pro-brain natriuretic peptide levels in subjects with acute exacerbations of COPD.
International journal of chronic obstructive pulmonary disease.
2019 ; 14(?):73-80. doi:
10.2147/copd.s186872. [PMID: 30587963] - Chau L B Ho, Enayet K Chowdhury, Monique Breslin, Jenny Doust, Christopher M Reid, Lindon M H Wing, Mark R Nelson. Short- and long-term association of lipid-lowering drug treatment and cardiovascular disease by estimated absolute risk in the Second Australian National Blood Pressure study.
Journal of clinical lipidology.
2019 Jan; 13(1):148-155. doi:
10.1016/j.jacl.2018.08.014. [PMID: 30293937] - Ewa Klara Stuermer, Manuela Besser, Nils Terberger, Hagen Sjard Bachmann, Anna-Lena Severing. Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro.
Skin pharmacology and physiology.
2019; 32(3):162-172. doi:
10.1159/000499433. [PMID: 31018213] - Robert M Rapoport, Amanda J LeBlanc, Jason E Beare, Manoocher Soleimani. Lack of thiazide diuretic inhibition of agonist constriction of mouse mesenteric arterioles ex vivo.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 01; 392(1):117-121. doi:
10.1007/s00210-018-1590-5. [PMID: 30470918] - Juan Wei, Wenjuan Ma, Guangzhe Yao, Qi Jia, Xuejing Cheng, Huizi Ouyang, Yanxu Chang, Xiaopeng Chen, Jun He. A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats.
BioMed research international.
2019; 2019(?):7537618. doi:
10.1155/2019/7537618. [PMID: 31467909] - Ron T Varghese, Khaled Khasawneh, Raman K Desikan, Anandaraj Subramaniam, Todd Weaver, Ganesh K V Nair. Vitamin A and Hydrochlorothiazide Causing Severe Hypercalcemia in a Patient With Primary Hyperparathyroidism.
Journal of investigative medicine high impact case reports.
2019 Jan; 7(?):2324709618823805. doi:
10.1177/2324709618823805. [PMID: 30791717] - Chien-Ming Lin, Chih-Jen Cheng, Sung-Sen Yang, Min-Hua Tseng, Ming-Tso Yen, Chih-Chien Sung, Shih-Hua Lin. Generation and analysis of a mouse model of pseudohypoaldosteronism type II caused by KLHL3 mutation in BTB domain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 01; 33(1):1051-1061. doi:
10.1096/fj.201801023r. [PMID: 30148674] - Nasser A Dhayat, Nicolas Faller, Olivier Bonny, Nilufar Mohebbi, Alexander Ritter, Lisa Pellegrini, Giulia Bedino, Carlo Schönholzer, Reto M Venzin, Carina Hüsler, Irene Koneth, Rosaria Del Giorno, Luca Gabutti, Patrizia Amico, Michael Mayr, Urs Odermatt, Florian Buchkremer, Thomas Ernandez, Catherine Stoermann-Chopard, Daniel Teta, Felix Rintelen, Marie Roumet, Irina Irincheeva, Sven Trelle, Luca Tamò, Beat Roth, Bruno Vogt, Daniel G Fuster. Efficacy of standard and low dose hydrochlorothiazide in the recurrence prevention of calcium nephrolithiasis (NOSTONE trial): protocol for a randomized double-blind placebo-controlled trial.
BMC nephrology.
2018 12; 19(1):349. doi:
10.1186/s12882-018-1144-6. [PMID: 30526528] - Marianne A Mahrouse. Simultaneous ultraperformance liquid chromatography/tandem mass spectrometry determination of four antihypertensive drugs in human plasma using hydrophilic-lipophilic balanced reversed-phase sorbents sample preparation protocol.
Biomedical chromatography : BMC.
2018 Dec; 32(12):e4362. doi:
10.1002/bmc.4362. [PMID: 30109716] - Bhargav Patel, Arvind G Jangid, B N Suhagia, Nirmal Desai. Challenges in Simultaneous Determination of Hydrochlorothiazide and Ramipril in Human Plasma: Application to a Bioequivalence Study.
Journal of chromatographic science.
2018 Nov; 56(10):867-878. doi:
10.1093/chromsci/bmy055. [PMID: 29897424] - Marzia Cirri, Lavinia Maestrini, Francesca Maestrelli, Natascia Mennini, Paola Mura, Carla Ghelardini, Lorenzo Di Cesare Mannelli. Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy.
Drug delivery.
2018 Nov; 25(1):1910-1921. doi:
10.1080/10717544.2018.1529209. [PMID: 30451015] - Maria Fernanda de Moura Leão, Jonathaline Apollo Duarte, Patrícia Dutra Sauzen, Jacqueline da Costa Escobar Piccoli, Luís Flávio Souza de Oliveira, Michel Mansur Machado. Cytotoxic and genotoxic effects of antihypertensives distributed in Brazil by social programs: Are they safe?.
Environmental toxicology and pharmacology.
2018 Oct; 63(?):1-5. doi:
10.1016/j.etap.2018.08.005. [PMID: 30107356] - Yuichi Akaba, Satoru Takahashi, Yoshiaki Sasaki, Hiroki Kajino. Successful treatment of normokalemic periodic paralysis with hydrochlorothiazide.
Brain & development.
2018 Oct; 40(9):833-836. doi:
10.1016/j.braindev.2018.05.011. [PMID: 29907477] - Gustavo Frindt, Lei Yang, Krister Bamberg, Lawrence G Palmer. Na restriction activates epithelial Na channels in rat kidney through two mechanisms and decreases distal Na+ delivery.
The Journal of physiology.
2018 08; 596(16):3585-3602. doi:
10.1113/jp275988. [PMID: 29737520] - Takahiro Yamauchi, Shigehiro Doi, Ayumu Nakashima, Toshiki Doi, Eisei Sohara, Shinichi Uchida, Takao Masaki. Na+-Cl- cotransporter-mediated chloride uptake contributes to hypertension and renal damage in aldosterone-infused rats.
American journal of physiology. Renal physiology.
2018 08; 315(2):F300-F312. doi:
10.1152/ajprenal.00504.2016. [PMID: 29631358] - Gilles R Dagenais, Hyejung Jung, Eva Lonn, Peter M Bogaty, Mahshid Dehghan, Claes Held, Alvaro Avezum, Petr Jansky, Matyàs Keltai, Lawrence A Leiter, Patricio Lopez-Jaramillo, William D Toff, Jackie Bosch, Salim Yusuf. Effects of Lipid-Lowering and Antihypertensive Treatments in Addition to Healthy Lifestyles in Primary Prevention: An Analysis of the HOPE-3 Trial.
Journal of the American Heart Association.
2018 07; 7(15):. doi:
10.1161/jaha.118.008918. [PMID: 30033433] - Wouter H van Megen, Paul R Grimm, Paul A Welling, Jenny van der Wijst. Renal sodium and magnesium reabsorption are not coupled in a mouse model of Gordon syndrome.
Physiological reports.
2018 07; 6(14):e13728. doi:
10.14814/phy2.13728. [PMID: 30030908] - Amir M Ramezani, Ghodratollah Absalan, Raheleh Ahmadi. Green-modified micellar liquid chromatography for isocratic isolation of some cardiovascular drugs with different polarities through experimental design approach.
Analytica chimica acta.
2018 Jun; 1010(?):76-85. doi:
10.1016/j.aca.2017.12.021. [PMID: 29447674] - Luay Alshara, Carlos A Batagello, Sherif Armanyous, Tianming Gao, Nishant Patel, Erick M Remer, Manoj Monga. The Impact of Thiazides and Potassium Citrate on Bone Mineral Density Evaluated by CT Scan in Stone Formers.
Journal of endourology.
2018 06; 32(6):559-564. doi:
10.1089/end.2017.0940. [PMID: 29641346] - Fabile Schlickmann, Thaise Boeing, Luisa Nathália Bolda Mariano, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Luisa Mota da Silva, Sérgio Faloni de Andrade, Priscila de Souza, Valdir Cechinel-Filho. Gallic acid, a phenolic compound isolated from Mimosa bimucronata (DC.) Kuntze leaves, induces diuresis and saluresis in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2018 06; 391(6):649-655. doi:
10.1007/s00210-018-1502-8. [PMID: 29663016] - Autumn N Harris, P Richard Grimm, Hyun-Wook Lee, Eric Delpire, Lijuan Fang, Jill W Verlander, Paul A Welling, I David Weiner. Mechanism of Hyperkalemia-Induced Metabolic Acidosis.
Journal of the American Society of Nephrology : JASN.
2018 05; 29(5):1411-1425. doi:
10.1681/asn.2017111163. [PMID: 29483157] - N Ayasse, P I A de Bruijn, P Berg, M V Sørensen, J Leipziger. Hydrochlorothiazide and acute urinary acidification: The "voltage hypothesis" of ENaC-dependent H+ secretion refuted.
Acta physiologica (Oxford, England).
2018 05; 223(1):e13013. doi:
10.1111/apha.13013. [PMID: 29226589] - Eero M Ala-Mutka, Jenni M Rimpelä, Frej Fyhrquist, Kimmo K Kontula, Timo P Hiltunen. Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.
Pharmacogenomics.
2018 04; 19(6):517-527. doi:
10.2217/pgs-2017-0184. [PMID: 29580174] - Caitrin W McDonough, Oyunbileg Magvanjav, Ana C C Sá, Nihal M El Rouby, Chintan Dave, Amelia N Deitchman, Marina Kawaguchi-Suzuki, Wenbin Mei, Yong Shen, Ravi Shankar Prasad Singh, Mohamed Solayman, Kent R Bailey, Eric Boerwinkle, Arlene B Chapman, John G Gums, Amy Webb, Steven E Scherer, Wolfgang Sadee, Stephen T Turner, Rhonda M Cooper-DeHoff, Yan Gong, Julie A Johnson. Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).
Circulation. Genomic and precision medicine.
2018 04; 11(4):e001854. doi:
10.1161/circgen.117.001854. [PMID: 29650764] - William C Cushman, George L Bakris, William B White, Michael A Weber, Domenic Sica, Andrew Roberts, Eric Lloyd, Stuart Kupfer. A randomized titrate-to-target study comparing fixed-dose combinations of azilsartan medoxomil and chlorthalidone with olmesartan and hydrochlorothiazide in stage-2 systolic hypertension.
Journal of hypertension.
2018 04; 36(4):947-956. doi:
10.1097/hjh.0000000000001647. [PMID: 29334491] - Ming-Xiao Wang, Catherina A Cuevas, Xiao-Tong Su, Peng Wu, Zhong-Xiuzi Gao, Dao-Hong Lin, James A McCormick, Chao-Ling Yang, Wen-Hui Wang, David H Ellison. Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel.
Kidney international.
2018 04; 93(4):893-902. doi:
10.1016/j.kint.2017.10.023. [PMID: 29310825] - George L Bakris, Lin Zhao, Stuart Kupfer, Attila Juhasz, Michie Hisada, Eric Lloyd, Suzanne Oparil. Long-term efficacy and tolerability of azilsartan medoxomil/chlorthalidone vs olmesartan medoxomil/hydrochlorothiazide in chronic kidney disease.
Journal of clinical hypertension (Greenwich, Conn.).
2018 04; 20(4):694-702. doi:
10.1111/jch.13230. [PMID: 29504252] - Jeannine Witte, Josephine Lampe, Anna Koenen, Ines Urbaneck, Antje Steinbach, Rainer Rettig, Olaf Grisk. The role of distal tubule and collecting duct sodium reabsorption in sunitinib-induced hypertension.
Journal of hypertension.
2018 04; 36(4):892-903. doi:
10.1097/hjh.0000000000001650. [PMID: 29283974] - Reinhold Kreutz, Jurgen Scholze, Antonios Douros. Single-Pill Triple Fixed Dose Combination Therapy with Single Component Drug Monitoring in Treatment-Resistant Hypertension: A Pilot Study.
Current vascular pharmacology.
2018 01; 16(2):197-203. doi:
10.2174/1570161115666170821155555. [PMID: 28828980] - Mark C van der Wel, Marion Biermans, Reinier Akkermans, Jacques W M Lenders, Chris van Weel, Jaap Deinum. Patient characteristics do not predict the individual response to antihypertensive medication: a cross-over trial.
Family practice.
2018 01; 35(1):67-73. doi:
10.1093/fampra/cmx075. [PMID: 28968870] - Camila Leandra Bueno de Almeida, Valdir Cechinel-Filho, Thaise Boeing, Luísa Nathália Bolda Mariano, Luísa Mota da Silva, Sérgio Faloni de Andrade, Priscila de Souza. Prolonged diuretic and saluretic effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats: Role of antioxidant system and renal protection.
Chemico-biological interactions.
2018 Jan; 279(?):227-233. doi:
10.1016/j.cbi.2017.11.021. [PMID: 29198636] - Robert D Brook, Niko Kaciroti, George Bakris, Björn Dahlöf, Bertram Pitt, Eric Velazquez, Michael Weber, Dion H Zappe, Tsushung Hau, Kenneth A Jamerson. Prior Medications and the Cardiovascular Benefits From Combination Angiotensin-Converting Enzyme Inhibition Plus Calcium Channel Blockade Among High-Risk Hypertensive Patients.
Journal of the American Heart Association.
2018 01; 7(1):. doi:
10.1161/jaha.117.006940. [PMID: 29301757]