Doxorubicin (BioDeep_00000001462)

 

Secondary id: BioDeep_00000270887

human metabolite blood metabolite Chemicals and Drugs Antibiotics natural product


代谢物信息卡片


(8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione

化学式: C27H29NO11 (543.1741)
中文名称: 阿霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 29.21%

分子结构信息

SMILES: c(c43)(C[C@](C(=O)CO)(C[C@@H]4OC(C5)O[C@@H](C)[C@@H](O)[C@@H](N)5)O)c(O)c(c1c(O)3)c(c(c2)c(c(OC)cc2)c1=O)=O
InChI: InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1

描述信息

Doxorubicin is only found in individuals that have used or taken this drug. It is antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of daunorubicin. [PubChem]Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01D - Cytotoxic antibiotics and related substances > L01DB - Anthracyclines and related substances
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D004791 - Enzyme Inhibitors
KEIO_ID D064

同义名列表

57 个代谢物同义名

(8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione; (8S-cis)-10-((3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; (8S-cis)-10-((3-Amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; (8S-cis)-10-((3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; (1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside; (1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside; Bristol-myers squibb brand OF doxorubicin hydrochloride; Tedec meiji brand OF doxorubicin hydrochloride; Ribosepharm brand OF doxorubicin hydrochloride; Cell pharm brand OF doxorubicin hydrochloride; Prasfarma brand OF doxorubicin hydrochloride; Onkoworks brand OF doxorubicin hydrochloride; Columbia brand OF doxorubicin hydrochloride; Kenfarma brand OF doxorubicin hydrochloride; Neocorp brand OF doxorubicin hydrochloride; Bedford brand OF doxorubicin hydrochloride; Ferrer brand OF doxorubicin hydrochloride; Lemery brand OF doxorubicin hydrochloride; Baxter brand OF doxorubicin hydrochloride; Pfizer brand OF doxorubicin hydrochloride; Medac brand OF doxorubicin hydrochloride; Hexal brand OF doxorubicin hydrochloride; Elan brand OF doxorubicin hydrochloride; Hydrochloride, Doxorubicin; Doxorubicin Hydrochloride; Doxorubicina Ferrer Farm; 14-Hydroxydaunorubicine; 14-Hydroxydaunomycin; Doxorubicine Baxter; Doxorubicina Tedec; Doxorubicina Funk; Doxorubicin Hexal; Urokit Doxo-cell; Urokit Doxo cell; Doxorubicin NC; Doxorubicinum; Farmiblastina; Adriablastine; Adriablastin; Adriblastine; Doxorubicine; Adriblastina; Adriblastin; Doxorubicin; Adriamycin; Adrimedac; DOXO cell; DOXO-cell; Ribodoxo; Doxotec; Onkodox; Doxolem; Myocet; Rubex; ADR; Doxorubicin



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

10 个相关的代谢反应过程信息。

Reactome(9)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

147 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AFP, BRCA1, CDH1, EGFR, HIF1A, MAPK8, MCL1, MVP, PGP, PGR, PIK3C3, TNFRSF8, TUBB4B, VIM
Endosome membrane 2 EGFR, TF
Endoplasmic reticulum membrane 1 EGFR
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 11 BRCA1, CDH1, EGFR, HIF1A, JUN, MAPK8, MCL1, MVP, PGR, SMUG1, TUBB4B
autophagosome 1 PIK3C3
cytosol 10 CDH1, HIF1A, MAPK8, MCL1, MVP, PGR, PIK3C3, SMUG1, TUBB4B, VIM
nuclear body 2 BRCA1, HIF1A
phagocytic vesicle 1 VIM
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
trans-Golgi network 1 CDH1
nucleoplasm 9 BRCA1, CDH1, HIF1A, JUN, MAPK8, MCL1, PGR, SMUG1, TNFRSF8
RNA polymerase II transcription regulator complex 2 HIF1A, JUN
Cell membrane 4 CDH1, EGFR, PDCD1, VIM
lamellipodium 1 CDH1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Synapse 1 MAPK8
cell junction 2 CDH1, EGFR
cell surface 2 EGFR, TF
glutamatergic synapse 3 CDH1, EGFR, PIK3C3
Golgi apparatus 1 CDH1
Golgi membrane 1 EGFR
postsynapse 1 CDH1
endosome 3 CDH1, EGFR, PIK3C3
plasma membrane 8 BRCA1, CDH1, EGFR, PDCD1, PGR, TF, TNFRSF8, VIM
Membrane 7 BRCA1, CDH1, EGFR, MCL1, MVP, PDCD1, PIK3C3
apical plasma membrane 2 EGFR, TF
axon 2 MAPK8, VIM
basolateral plasma membrane 1 EGFR
extracellular exosome 7 BMP3, CDH1, MVP, TF, TNFRSF8, TUBB4B, VIM
extracellular space 5 AFP, BMP3, EGFR, IL2, TF
perinuclear region of cytoplasm 4 CDH1, EGFR, MVP, TF
adherens junction 1 CDH1
mitochondrion 1 MCL1
protein-containing complex 3 BRCA1, EGFR, HIF1A
Single-pass type I membrane protein 3 CDH1, EGFR, TNFRSF8
Secreted 4 AFP, BMP3, IL2, TF
extracellular region 6 BMP3, CDH1, IL2, MVP, TF, TUBB4B
cytoplasmic side of plasma membrane 1 CDH1
Single-pass membrane protein 1 MCL1
mitochondrial outer membrane 2 MCL1, PGR
basal part of cell 1 TF
transcription regulator complex 1 JUN
motile cilium 1 HIF1A
Bcl-2 family protein complex 1 MCL1
nuclear membrane 2 CDH1, EGFR
external side of plasma membrane 1 PDCD1
Extracellular vesicle 1 TUBB4B
actin cytoskeleton 1 CDH1
cytoplasmic vesicle 1 TF
microtubule cytoskeleton 1 TUBB4B
nucleolus 1 SMUG1
axon cytoplasm 1 HIF1A
midbody 1 PIK3C3
Early endosome 1 TF
clathrin-coated pit 1 TF
recycling endosome 1 TF
vesicle 1 TF
Cytoplasm, perinuclear region 1 MVP
Membrane raft 1 EGFR
Cytoplasm, cytoskeleton 2 TUBB4B, VIM
focal adhesion 2 EGFR, VIM
microtubule 1 TUBB4B
GABA-ergic synapse 1 PIK3C3
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
Peroxisome 2 PIK3C3, VIM
intracellular vesicle 1 EGFR
intermediate filament 1 VIM
lateral plasma membrane 1 CDH1
axoneme 1 PIK3C3
nuclear speck 1 HIF1A
Late endosome 2 PIK3C3, TF
receptor complex 1 EGFR
neuron projection 1 VIM
chromatin 3 HIF1A, JUN, PGR
cell leading edge 1 VIM
phagocytic vesicle membrane 1 PIK3C3
mitotic spindle 1 TUBB4B
Chromosome 1 BRCA1
cytoskeleton 3 MVP, TUBB4B, VIM
[Isoform 5]: Cytoplasm 1 BRCA1
Golgi apparatus, trans-Golgi network 1 CDH1
nuclear chromosome 1 JUN
blood microparticle 1 TF
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
fibrillar center 1 SMUG1
Nucleus, nuclear pore complex 1 MVP
nuclear pore 1 MVP
axonemal microtubule 1 TUBB4B
microtubule organizing center 1 VIM
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
lateral element 1 BRCA1
myosin complex 1 MCL1
Nucleus, nucleoplasm 1 MCL1
Nucleus speckle 1 HIF1A
euchromatin 2 HIF1A, JUN
intermediate filament cytoskeleton 1 VIM
ubiquitin ligase complex 1 BRCA1
basal plasma membrane 2 EGFR, TF
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MVP
secretory granule lumen 2 MVP, TF
HFE-transferrin receptor complex 1 TF
endoplasmic reticulum lumen 2 AFP, TF
nuclear matrix 1 VIM
male germ cell nucleus 1 BRCA1
XY body 1 BRCA1
endocytic vesicle 1 TF
azurophil granule lumen 1 TUBB4B
anaphase-promoting complex 1 CDH1
presynaptic endosome 1 PIK3C3
Nucleus matrix 1 VIM
[Isoform 2]: Cytoplasm 1 TNFRSF8
clathrin-coated endocytic vesicle membrane 2 EGFR, TF
ribonucleoprotein complex 2 BRCA1, MVP
[Isoform 2]: Nucleus 1 CDH1
basal dendrite 1 MAPK8
apical junction complex 1 CDH1
[Isoform 1]: Cell membrane 1 TNFRSF8
intracellular non-membrane-bounded organelle 1 BRCA1
DNA repair complex 1 BRCA1
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 1 CDH1
BRCA1-C complex 1 BRCA1
vesicle coat 1 TF
postsynaptic endosome 1 PIK3C3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transcription factor AP-1 complex 1 JUN
Autolysosome 1 PIK3C3
[Isoform 4]: Mitochondrion outer membrane 1 PGR
BRCA1-A complex 1 BRCA1
BRCA1-B complex 1 BRCA1
BRCA1-BARD1 complex 1 BRCA1
gamma-tubulin ring complex 1 BRCA1
nuclear ubiquitin ligase complex 1 BRCA1
dense body 1 TF


文献列表

  • Peijun Sun, Huixian Chen, Xiaoyu Fan, Jiayi Wang, Lujie Lu, Guangchao Yang, Jining Liu, Weifeng Yao, Feng Ding, Jie Ding, Jianmei Liu, Tulin Lu, Lihong Chen. Exploring the effective components of honey-processed licorice (Glycyrrhiza uralensis Fisch.) in attenuating Doxorubicin-induced myocardial cytotoxicity by combining network pharmacology and in vitro experiments. Journal of ethnopharmacology. 2024 Jul; 329(?):118178. doi: 10.1016/j.jep.2024.118178. [PMID: 38604511]
  • Yuanyuan Chen, Xikun Liu, Jie Ma, Weida Wang, Zhaojun Li, Haijie Wu, Zhanxi Lu, Dongming Zhang, Xiaoying Zhang, Yu Zhang, Sen Zhang. Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ. Journal of ethnopharmacology. 2024 Jul; 329(?):118156. doi: 10.1016/j.jep.2024.118156. [PMID: 38583729]
  • Yuexiao Tang, Tao Yao, Xin Tian, Xintong Xia, Xingxiao Huang, Zhewen Qin, Zhong Shen, Lin Zhao, Yaping Zhao, Bowen Diao, Yan Ping, Xiaoxiao Zheng, Yonghao Xu, Hui Chen, Tao Qian, Tao Ma, Ben Zhou, Suowen Xu, Qimin Zhou, Yong Liu, Mengle Shao, Wei Chen, Bo Shan, Ying Wu. Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy. The Journal of experimental medicine. 2024 Jul; 221(7):. doi: 10.1084/jem.20231395. [PMID: 38695876]
  • Elaheh Mirhadi, Anis Askarizadeh, Leila Farhoudi, Mohammad Mashreghi, Saeed Behboodifar, Seyedeh Hoda Alavizadeh, Leila Arabi, Mahmoud Reza Jaafari. The impact of phospholipids with high transition temperature to enhance redox-sensitive liposomal doxorubicin efficacy in colon carcinoma model. Chemistry and physics of lipids. 2024 Jul; 261(?):105396. doi: 10.1016/j.chemphyslip.2024.105396. [PMID: 38621603]
  • Xuan Zhang, Chaoming Huang, Yanhong Hou, Shisheng Jiang, Yu Zhang, Shulin Wang, Jiamin Chen, Jianmei Lai, Lifeng Wu, Huiying Duan, Shuwen He, Xinyi Liu, Shanshan Yu, Yi Cai. Research progress on the role and mechanism of Sirtuin family in doxorubicin cardiotoxicity. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155673. doi: 10.1016/j.phymed.2024.155673. [PMID: 38677274]
  • Ji-Hye Song, Min-Sun Kim, Seung-Hyun Lee, Jin-Taek Hwang, Soo-Hyun Park, Sahng Wook Park, Sae-Bom Jeon, Ru-Ri Lee, Jangho Lee, Hyo-Kyoung Choi. Hydroethanolic extract of Cirsium setidens ameliorates doxorubicin-induced cardiotoxicity by AMPK-PGC-1α-SOD-mediated mitochondrial protection. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155633. doi: 10.1016/j.phymed.2024.155633. [PMID: 38640859]
  • Jagadish Natesh, Priya Mondal, Dhanamjai Penta, Yahya Mukhlis, Devendra Jaganath Haware, Syed Musthapa Meeran. Protective effect of diindolylmethane-enriched dietary cabbage against doxorubicin-induced cardiotoxicity in mice. Journal of applied toxicology : JAT. 2024 06; 44(6):874-891. doi: 10.1002/jat.4588. [PMID: 38327044]
  • Yanwei Wang, Jingru Qiu, Hua Yan, Nan Zhang, Shixuan Gao, Ning Xu, Cuiyan Wang, Haiyan Lou. The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice. Archives of toxicology. 2024 Jun; 98(6):1781-1794. doi: 10.1007/s00204-024-03697-3. [PMID: 38573338]
  • Udayakumar Karunakaran, Eun Yeong Ha, Suma Elumalai, Kyu Chang Won, Jun Sung Moon. Mitochondrial ALDH2 improves ß-cell survival and function against doxorubicin-induced apoptosis by targeting CK2 signaling. Journal of diabetes investigation. 2024 Jun; 15(6):684-692. doi: 10.1111/jdi.14230. [PMID: 38713732]
  • Yafei Zhai, Jinmeng Bai, Ying Peng, Jinhua Cao, Guangming Fang, Yiming Dong, Ze Wang, Yanyu Lu, Mengyu Wang, Mengduan Liu, Yangyang Liu, Xiaowei Li, Jianzeng Dong, Xiaoyan Zhao. Ginsenoside Rb1 attenuates doxorubicin induced cardiotoxicity by suppressing autophagy and ferroptosis. Biochemical and biophysical research communications. 2024 May; 710(?):149910. doi: 10.1016/j.bbrc.2024.149910. [PMID: 38593619]
  • Sooho Yeo, Huiqiang Wu, Il Yoon, Woo Kyoung Lee, Sung-Joo Hwang. Design of smart chemotherapy of doxorubicin hydrochloride using nanostructured lipid carriers and solid lipid nanoparticles for improved anticancer efficacy. International journal of pharmaceutics. 2024 May; 657(?):124048. doi: 10.1016/j.ijpharm.2024.124048. [PMID: 38537925]
  • Gang Tan, Guanghui Hou, Junmin Qian, Yaping Wang, Weijun Xu, Wenjuan Luo, Xiaobing Chen, Aili Suo. Hyaluronan-decorated copper-doxorubicin-anlotinib nanoconjugate for targeted synergistic chemo/chemodynamic/antiangiogenic tritherapy against hepatocellular carcinoma. Journal of colloid and interface science. 2024 May; 662(?):857-869. doi: 10.1016/j.jcis.2024.02.085. [PMID: 38382370]
  • Yufan Guo, Xiuru Yang, Yihong Zhang, Fazhen Luo, Juan Yang, Xupeng Zhang, Jinxia Mi, Yan Xie. Hyaluronic acid/dextran-based polymeric micelles co-delivering ursolic acid and doxorubicin to mitochondria for potentiating chemotherapy in MDR cancer. Carbohydrate polymers. 2024 May; 332(?):121897. doi: 10.1016/j.carbpol.2024.121897. [PMID: 38431408]
  • Shulei Zhang, Bo Zheng, Yiqi Wei, Yuhao Liu, Lan Yang, Yujiao Qiu, Jing Su, Mingfeng Qiu. Bioinspired ginsenoside Rg3 PLGA nanoparticles coated with tumor-derived microvesicles to improve chemotherapy efficacy and alleviate toxicity. Biomaterials science. 2024 May; 12(10):2672-2688. doi: 10.1039/d4bm00159a. [PMID: 38596867]
  • Lina Zhao, Yanjiao Wang, Yi Zhang, Hao Chen, Fude Sun. Dynamic Simulations of Interaction of the PEG-DPPE Micelle-Encapsulated Short-Chain Ceramides with the Raft-Included Membrane. Journal of chemical information and modeling. 2024 May; 64(9):3874-3883. doi: 10.1021/acs.jcim.4c00170. [PMID: 38652138]
  • Guangyang Jiao, Yejian Wang, Yue Song, Yuxin Chen, Xiangcheng Fan, Qing Zhao, Tao Pang, Feng Zhang, Wansheng Chen. Combination of ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry and network pharmacology to reveal the key effective compounds and mechanism of Shengxian decoction for ameliorating doxorubicin cardiotoxicity. Journal of separation science. 2024 May; 47(9-10):e2300867. doi: 10.1002/jssc.202300867. [PMID: 38726736]
  • Shujun Xu, Shuang Zheng, Ninghui Ma, Hongyan Zhang, Jingbin Shi, Jingyi Huang, Ninghchao Luo, Menglin Wang, Yang Xiong. Rhein potentiates doxorubicin in treating triple negative breast cancer by inhibiting cancer-associated fibroblasts. Biochemical pharmacology. 2024 May; 223(?):116139. doi: 10.1016/j.bcp.2024.116139. [PMID: 38499109]
  • Jianmei Li, Qian Wen, Jie Dai, Biqiong Wang, Yun Lu, Zhouxue Wu, Yu Fan, Fancai Zeng, Yue Chen, Yan Zhang, Renjin Chen, Shaozhi Fu. An oral bioactive chitosan-decorated doxorubicin nanoparticles/bacteria bioconjugates enhance chemotherapy efficacy in an in-situ breast cancer model. International journal of biological macromolecules. 2024 May; 267(Pt 1):131428. doi: 10.1016/j.ijbiomac.2024.131428. [PMID: 38583834]
  • Magy M Abo-Ser, El-Shahat A Toson, Ashraf A El-Bindary, Guy Schlatter, Kamel R Shoueir. Smart chitosan nanogel for targeted doxorubicin delivery, ensuring precise release, and minimizing side effects in Ehrlich ascites carcinoma-bearing mice. International journal of biological macromolecules. 2024 May; 267(Pt 1):131390. doi: 10.1016/j.ijbiomac.2024.131390. [PMID: 38582473]
  • Eun-Jeong Nam, Inyoung Cho, Hyeji Park, Seung R Paik. Multifactorial drug carrier system bringing both chemical and physical therapeutics to the treatment of tumor heterogeneity. Journal of controlled release : official journal of the Controlled Release Society. 2024 May; 369(?):101-113. doi: 10.1016/j.jconrel.2024.03.033. [PMID: 38508524]
  • Weili Li, Jing Cao, Yawen Zhang, Guanjing Ling, Nannan Tan, Yan Wei, Yuqin Zhang, Xiaoping Wang, Weina Qian, Jinchi Jiang, Jingmei Zhang, Wei Wang, Yong Wang. Aucubin alleviates doxorubicin-induced cardiotoxicity through crosstalk between NRF2 and HIPK2 mediating autophagy and apoptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 May; 127(?):155473. doi: 10.1016/j.phymed.2024.155473. [PMID: 38422972]
  • Yujing Feng, Huaiqing Wei, Meng Lyu, Zhiyuan Yu, Jia Chen, Xinxing Lyu, Fengfeng Zhuang. Iron retardation in lysosomes protects senescent cells from ferroptosis. Aging. 2024 Apr; 16(9):7683-7703. doi: 10.18632/aging.205777. [PMID: 38683121]
  • Oguzhan Birdal, Irmak Ferah Okkay, Ufuk Okkay, Cemil Bayram, Behzad Mokthare, Muhammed Sait Ertugrul, Ahmet Hacimuftuoglu, Emrah Aksakal, Yavuzer Koza, Mehmet Saygi, Huseyin Senocak. Protective effects of arbutin against doxorubicin-induced cardiac damage. Molecular biology reports. 2024 Apr; 51(1):532. doi: 10.1007/s11033-024-09488-4. [PMID: 38637360]
  • Mi Wang, Mo Zhang, Jianyi Bi, Jincan Li, Xiaoxiao Hu, Lina Zhang, Yao Zhang, Wenli Wang, Yuan Lin, Hong-Bo Cheng, Jing Wang. Mitochondrial Targeted Thermosensitive Nanocarrier for Near-Infrared-Triggered Precise Synergetic Photothermal Nitric Oxide Chemotherapy. ACS applied materials & interfaces. 2024 Apr; 16(15):18252-18267. doi: 10.1021/acsami.3c09997. [PMID: 38581365]
  • Ravindar Chinapaka, Dokku Sivaramakrishna, Suman Kumar Choudhury, Konga Manasa, Sudheer K Cheppali, Musti J Swamy. Structure, Self-Assembly, and Phase Behavior of Neuroactive N-Acyl GABAs: Doxorubicin Encapsulation in NPGABA/DPPC Liposomes and Release Studies. Langmuir : the ACS journal of surfaces and colloids. 2024 Apr; 40(15):7883-7895. doi: 10.1021/acs.langmuir.3c03615. [PMID: 38587263]
  • Jiale Yu, Xiaoxia Mao, Xue Yang, Guiqin Zhao, Songtao Li. New Transferrin Receptor-Targeted Peptide-Doxorubicin Conjugates: Synthesis and In Vitro Antitumor Activity. Molecules (Basel, Switzerland). 2024 Apr; 29(8):. doi: 10.3390/molecules29081758. [PMID: 38675578]
  • Yeonwoo Jang, Young Seok Cho, April Kim, Xingwu Zhou, Yujin Kim, Ziye Wan, James J Moon, Hansoo Park. CXCR4-Targeted Macrophage-Derived Biomimetic Hybrid Vesicle Nanoplatform for Enhanced Cancer Therapy through Codelivery of Manganese and Doxorubicin. ACS applied materials & interfaces. 2024 Apr; 16(14):17129-17144. doi: 10.1021/acsami.3c18569. [PMID: 38533538]
  • Hongwei Song, Junling Ren, Le Yang, Hui Sun, Guangli Yan, Ying Han, Xijun Wang. Elucidation for the pharmacological effects and mechanism of Shen Bai formula in treating myocardial injury based on energy metabolism and serum metabolomic approaches. Journal of ethnopharmacology. 2024 Apr; 323(?):117670. doi: 10.1016/j.jep.2023.117670. [PMID: 38160867]
  • Ya-Li Yang, Chuan-Zhi Zhao, Chun-Chun Zhao, Zhong-Yu Wen, Yao-Yao Ma, Xiao-Ni Zhao, Liang Wang, Jin-Ling Huang, Peng Zhou. Ling-Gui-Zhu-Gan decoction protects against doxorubicin-induced myocardial injury by downregulating ferroptosis. The Journal of pharmacy and pharmacology. 2024 Apr; 76(4):405-415. doi: 10.1093/jpp/rgae005. [PMID: 38241142]
  • Chu Erfu, Liu Li, Qu Weiting, Chi Tao, Ma Liwei, Yang Hemin, Lu Junkun. Matrine attenuating cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity through improved mitochondrial membrane potential and activation of mitochondrial respiratory chain Complex I pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116464. doi: 10.1016/j.biopha.2024.116464. [PMID: 38503242]
  • Yunfan Yang, Jiajun Ren, Jifeng Zhang, Henghe Shi, Junnan Wang, Youyou Yan. FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner. Redox biology. 2024 Apr; 70(?):103067. doi: 10.1016/j.redox.2024.103067. [PMID: 38316068]
  • Sujeong Lee, Hye Jin Kim, Jin-Ho Choi, Hye Jung Jang, Hui Bang Cho, Hye-Ryoung Kim, Ji-In Park, Kyung-Soon Park, Keun-Hong Park. Light emitting diode (LED) irradiation of liposomes enhances drug encapsulation and delivery for improved cancer eradication. Journal of controlled release : official journal of the Controlled Release Society. 2024 Apr; 368(?):756-767. doi: 10.1016/j.jconrel.2024.03.027. [PMID: 38499090]
  • Chuying Huang, Yishan Guo, Tuo Li, Guogen Sun, Jinru Yang, Yuqi Wang, Ying Xiang, Li Wang, Min Jin, Jiao Li, Yong Zhou, Bing Han, Rui Huang, Jiao Qiu, Yong Tan, Jiaxing Hu, Yumiao Wei, Bo Wu, Yong Mao, Lingshan Lei, Xiusheng Song, Shuijie Li, Yongsheng Wang, Tao Zhang. Pharmacological activation of GPX4 ameliorates doxorubicin-induced cardiomyopathy. Redox biology. 2024 Apr; 70(?):103024. doi: 10.1016/j.redox.2023.103024. [PMID: 38232458]
  • Sujuan Li, Sen Wang, Anping Zhang, Lixia Luo, Jie Song, Guoli Wei, Zhijun Fang. Cucurbitacin IIa promotes the immunogenic cell death‑inducing effect of doxorubicin and modulates immune microenvironment in liver cancer. International journal of oncology. 2024 04; 64(4):. doi: 10.3892/ijo.2024.5625. [PMID: 38391053]
  • Wei-Han Weng, Chu-Yun Wang, Zi-Yu Yan, Hsiang-Tzu Lee, Cheng-Yuan Kao, Chien-Wen Chang. Isolation and characterizations of multidrug-resistant human cancer cells by a biodegradable nano-sensor. Biosensors & bioelectronics. 2024 Apr; 249(?):115985. doi: 10.1016/j.bios.2023.115985. [PMID: 38219465]
  • Jiajin Xu, Zeyi Zhang, Hongtao Hu, Yaqin Yang, Chenghong Xiao, Luyi Xi, Jiahui Lu, Shasha Tian, Huajun Zhao. Synergistic antitumor effects of Peiminine and Doxorubicin on breast cancer through enhancing DNA damage via ZEB1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116353. doi: 10.1016/j.biopha.2024.116353. [PMID: 38432128]
  • Yaoxun Zeng, Jiongpeng Yuan, Zhili Ran, Xiaoguang Zhan, Xinyi Li, Huiling Ye, Jiapeng Dong, Guining Cao, Zhenxing Pan, Ying Bao, Junze Tang, Xujie Liu, Yan He. Chitosan/NH2-MIL-125 (Ti) scaffold loaded with doxorubicin for postoperative bone tumor clearance and osteogenesis: An in vitro study. International journal of biological macromolecules. 2024 Apr; 263(Pt 2):130368. doi: 10.1016/j.ijbiomac.2024.130368. [PMID: 38401584]
  • Jia Liu, Honglin Liu, Liangyan Deng, Tao Wang, Luyao Li, Yuanyuan Chen, Liping Qu, Wenjun Zou. Protective Role of Dioscin against Doxorubicin-Induced Chronic Cardiotoxicity: Insights from Nrf2-GPX4 Axis-Mediated Cardiac Ferroptosis. Biomolecules. 2024 Mar; 14(4):. doi: 10.3390/biom14040422. [PMID: 38672439]
  • Sajid Ali, Jonas K Koehler, Luís Silva, Lars Gedda, Ulrich Massing, Katarina Edwards. Dual centrifugation as a novel and efficient method for the preparation of lipodisks. International journal of pharmaceutics. 2024 Mar; 653(?):123894. doi: 10.1016/j.ijpharm.2024.123894. [PMID: 38350501]
  • Mengying Wu, Wei Zhang, Xueru Zhou, Zijun Wang, Sha Li, Chenqi Guo, Yuping Yang, Rongping Zhang, Zhirong Zhang, Xun Sun, Tao Gong. An in situ forming gel co-loaded with pirarubicin and celecoxib inhibits postoperative recurrence and metastasis of breast cancer. International journal of pharmaceutics. 2024 Mar; 653(?):123897. doi: 10.1016/j.ijpharm.2024.123897. [PMID: 38360289]
  • Asep Bayu, Siti Irma Rahmawati, Firmansyah Karim, Jonathan Ardhianto Panggabean, Dasilva Primarindu Nuswantari, Dwi Wahyu Indriani, Peni Ahmadi, Rendi Witular, Ni Luh Putu Indi Dharmayanti, Masteria Yunovilsa Putra. An In Vitro Examination of Whether Kratom Extracts Enhance the Cytotoxicity of Low-Dose Doxorubicin against A549 Human Lung Cancer Cells. Molecules (Basel, Switzerland). 2024 Mar; 29(6):. doi: 10.3390/molecules29061404. [PMID: 38543040]
  • Artūras Polita, Rokas Žvirblis, Jelena Dodonova-Vaitkūnienė, Arun Prabha Shivabalan, Karolina Maleckaitė, Gintaras Valinčius. Bimodal effects on lipid droplets induced in cancer and non-cancer cells by chemotherapy drugs as revealed with a green-emitting BODIPY fluorescent probe. Journal of materials chemistry. B. 2024 Mar; 12(12):3022-3030. doi: 10.1039/d3tb02979d. [PMID: 38426244]
  • Caiyang Xie, Binke Wang, Xinyu Qi, Lei Bao, Jiali Zhai, Xu Xu, Chunli Zhang, Haitao Yu. Investigation of Anticancer Therapy Using pH-Sensitive Carbon Dots-Functionalized Doxorubicin in Cubosomes. ACS applied bio materials. 2024 Mar; 7(3):1958-1967. doi: 10.1021/acsabm.3c01306. [PMID: 38363649]
  • Shili Ai, Qinzong Gao, Gele Cheng, Pengfei Zhong, Peiyu Cheng, Yingying Ren, Hao Wang, Xu Zhu, Shanyue Guan, Xiaozhong Qu. Construction of an Injectable Composite Double-Network Hydrogel as a Liquid Embolic Agent. Biomacromolecules. 2024 Mar; 25(3):2052-2064. doi: 10.1021/acs.biomac.3c01437. [PMID: 38426456]
  • Abdelkader A Metwally, Samayita Ganguly, Nora Biomi, Mingyi Yao, Tamer Elbayoumi. Cationic Vitamin E-TPGS Mixed Micelles of Berberine to Neutralize Doxorubicin-Induced Cardiotoxicity via Amelioration of Mitochondrial Dysfunction and Impeding Apoptosis. Molecules (Basel, Switzerland). 2024 Mar; 29(5):. doi: 10.3390/molecules29051155. [PMID: 38474668]
  • Sachin Gudasi, Shankar Gharge, Rahul Koli, Pooja Kagawad. Exploring In-Silico, In-Vitro Antioxidant, and Cytotoxic Potential of Valerian wallichii by On Cervical Epithelial Carcinoma (HeLa) Cell Lines. Chemistry & biodiversity. 2024 Mar; 21(3):e202302072. doi: 10.1002/cbdv.202302072. [PMID: 38268315]
  • Minyi Zhang, Ying Chen, Qi Wang, Chunlin Li, Chunping Yuan, Jie Lu, Yu Luo, Xijian Liu. Nanocatalytic theranostics with intracellular mutual promotion for ferroptosis and chemo-photothermal therapy. Journal of colloid and interface science. 2024 Mar; 657(?):619-631. doi: 10.1016/j.jcis.2023.12.006. [PMID: 38071811]
  • Huiling Su, Jing Jia, Yuxiang Mao, Riran Zhu, Zhengjun Li. A real-world analysis of FDA Adverse Event Reporting System (FAERS) events for liposomal and conventional doxorubicins. Scientific reports. 2024 03; 14(1):5095. doi: 10.1038/s41598-024-55185-4. [PMID: 38429374]
  • Pinunta Nittayacharn, Eric Abenojar, Michaela B Cooley, Felipe M Berg, Claire Counil, Amin Jafari Sojahrood, Muhammad Saad Khan, Celina Yang, Elizabeth Berndl, Marcin Golczak, Michael C Kolios, Agata A Exner. Efficient ultrasound-mediated drug delivery to orthotopic liver tumors - Direct comparison of doxorubicin-loaded nanobubbles and microbubbles. Journal of controlled release : official journal of the Controlled Release Society. 2024 Mar; 367(?):135-147. doi: 10.1016/j.jconrel.2024.01.028. [PMID: 38237687]
  • Jianfeng Jiang, Zhilian Su, Qin He, Wengui Duan, Yan Huang, Luzhi Liu. A Nanoplatform Based on Pillar[5]arene Nanovalves for Combined Drug Delivery and Enhanced Antitumor Activity. Chemistry (Weinheim an der Bergstrasse, Germany). 2024 Mar; 30(13):e202400007. doi: 10.1002/chem.202400007. [PMID: 38258423]
  • Waraporn Yahayo, Veerachai Pongkittiphan, Roogntawan Supabphol, Somrudee Saiyudthong. Comparative Studies of Resveratrol, Oxyresveratrol and Dihydrooxyresveratrol on Doxorubicin-Treated Lung Cancer Cells. Asian Pacific journal of cancer prevention : APJCP. 2024 Mar; 25(3):939-949. doi: 10.31557/apjcp.2024.25.3.939. [PMID: 38546076]
  • Yang Lu, Xinglong Liu, Ting Zhao, Chuanbo Ding, Qiteng Ding, Ning Wang, Shuang Ma, Lina Ma, Wencong Liu. Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian Cancer. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29051042. [PMID: 38474556]
  • Yukiko Nishiguch, Rina Fujiwara-Tani, Shota Nukaga, Ryoichi Nishida, Ayaka Ikemoto, Rika Sasaki, Shiori Mori, Ruiko Ogata, Shingo Kishi, Yudai Hojo, Hisashi Shinohara, Masayuki Sho, Hiroki Kuniyasu. Pterostilbene Induces Apoptosis from Endoplasmic Reticulum Stress Synergistically with Anticancer Drugs That Deposit Iron in Mitochondria. International journal of molecular sciences. 2024 Feb; 25(5):. doi: 10.3390/ijms25052611. [PMID: 38473857]
  • Wei Ge, Weikang Ming, Zhenkun Li, Yunyan Tang, Ya-Nan Li, Jue Yang, Xiaojiang Hao, Chunmao Yuan. Design and Synthesis of Cytotoxic Water-Soluble Rocaglaol Derivatives against HEL Cells by Inhibiting Fli-1. Journal of natural products. 2024 02; 87(2):276-285. doi: 10.1021/acs.jnatprod.3c00948. [PMID: 38253024]
  • Ruizhi Lai, Zhiqian Lin, Chunyan Yang, Li Hai, Zhongzhen Yang, Li Guo, Ruifang Nie, Yong Wu. Novel berberine derivatives as p300 histone acetyltransferase inhibitors in combination treatment for breast cancer. European journal of medicinal chemistry. 2024 Feb; 266(?):116116. doi: 10.1016/j.ejmech.2023.116116. [PMID: 38215590]
  • Jaroslaw Szponar, Agnieszka Gorska, Marta Ostrowska-Lesko, Agnieszka Korga-Plewko, Michal Tchorz, Erwin Ciechanski, Anna Dabrowska, Ewa Poleszak, Franciszek Burdan, Jaroslaw Dudka, Marek Murias, Slawomir Mandziuk. Assessment of the Impact of Carvedilol Administered Together with Dexrazoxan and Doxorubicin on Liver Structure and Function, Iron Metabolism, and Myocardial Redox System in Rats. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042219. [PMID: 38396896]
  • Fang Xiong, Lin Pu, Daibo Wang, Fu Peng, Luyao Sun, Qian Yu, Xiaofang Xie, Cheng Peng. Investigation of polysaccharide from Radix Aconiti Lateralis Preparata (Fuzi) cardio protective effect on doxorubicin-induced chronic cardiotoxicity. The Journal of pharmacy and pharmacology. 2024 Jan; ?(?):. doi: 10.1093/jpp/rgae001. [PMID: 38289094]
  • Xiaoxu Zhang, Qi Zhang, Menghan Yu, Yanfei Zhang, Tianzhu He, Zhidong Qiu, Ye Qiu, Weinan Wang. Integrating serum pharmacochemistry and network pharmacology to explore the molecular mechanisms of Acanthopanax senticosus (Rupr. & Maxim.) Harms on attenuating doxorubicin-induced myocardial injury. Journal of ethnopharmacology. 2024 Jan; 319(Pt 3):117349. doi: 10.1016/j.jep.2023.117349. [PMID: 38380572]
  • Oluwatobiloba F Da-Silva, Adedoyin R Adelowo, Adesina A Babalola, Cynthia N Ikeji, Olatunde Owoeye, Joao B T Rocha, Isaac A Adedara, Ebenezer O Farombi. Diphenyl Diselenide Through Reduction of Inflammation, Oxidative Injury and Caspase-3 Activation Abates Doxorubicin-Induced Neurotoxicity in Rats. Neurochemical research. 2024 Jan; ?(?):. doi: 10.1007/s11064-023-04098-1. [PMID: 38267690]
  • Qian Liu, Xiangrong Tian, Kaimin Gong, Rui Qian, Song Shen. Size Switchable Self-Assembled Iron Oxide Aggregations Loaded with Doxorubicin for Deep Penetration and Enhanced Chemotherapy of Cancer. ACS applied bio materials. 2024 Jan; 7(1):297-305. doi: 10.1021/acsabm.3c00889. [PMID: 38103174]
  • Barakat M ALRashdi, Mohamed M Hussein, Rawan M Mohammed, Nada W Abdelhamed, Maran E Asaad, Mubarak Alruwaili, Saad M Alrashidi, Ola A Habotta, Ahmed Abdel Moneim, Shimaa S Ramadan. Turmeric Extract-loaded Selenium Nanoparticles Counter Doxorubicin-induced Hepatotoxicity in Mice via Repressing Oxidative Stress, Inflammatory Cytokines, and Cell Apoptosis. Anti-cancer agents in medicinal chemistry. 2024 Jan; ?(?):. doi: 10.2174/0118715206274530231213104519. [PMID: 38204261]
  • Alessandro Cazzolla, Julie Rose Mae Mondala, Janith Wanigasekara, Joanna Carroll, Noah Daly, Brijesh Tiwari, Alan Casey, James F Curtin. Synthesis of cationic liposome nanoparticles using a thin film dispersed hydration and extrusion method. PloS one. 2024; 19(4):e0300467. doi: 10.1371/journal.pone.0300467. [PMID: 38593146]
  • Yi Wu, Jiahui Tian, Jialu Yang, Qian Peng, Zhengchun Wu, Rushi Liu, Mengjie Luo, Yilan Qiu, Ruiyun Cao. Bufotalin-loaded biomimetic Prussian blue nanoparticles for colorectal cancer chemo-photothermal ferroptosis therapy. Nanomedicine (London, England). 2024 Jan; 19(2):109-125. doi: 10.2217/nnm-2023-0293. [PMID: 38197393]
  • Yasuyuki Sadzuka. [To Assess Drug Delivery System Nanocarrier at Industrial Production: Establishment of Liposomal Surface Using Physicochemical Properties]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2024; 144(1):61-69. doi: 10.1248/yakushi.23-00129. [PMID: 38171797]
  • Lijun Peng, Fangying Yu, Ruoyu Shen, Wentao Zhou, Ding Wang, Qi Jiang, Tingting Meng, Jianwei Wang, Fuqiang Hu, Hong Yuan. Glutathione Consumptive Dual-Sensitive Lipid-Composite Nanoparticles Induce Immunogenic Cell Death for Enhanced Breast Tumor Therapy. Molecular pharmaceutics. 2024 Jan; 21(1):113-125. doi: 10.1021/acs.molpharmaceut.3c00518. [PMID: 38081040]
  • Jong-Ryul Park, Gayoung Kim, Jongho Won, Chul-Woo Kim, Donghee Park. Evaluation of Doxorubicin-loaded Echogenic Macroemulsion for Targeted Drug Delivery. Current drug delivery. 2024; 21(5):785-793. doi: 10.2174/1567201820666230403111118. [PMID: 37016528]
  • Luxuan Shen, Pei Zhou, Yue Min Wang, Zhixiong Zhu, Quan Yuan, Shuqin Cao, Jianshu Li. Supramolecular nanoparticles based on elastin-like peptides modified capsid protein as drug delivery platform with enhanced cancer chemotherapy efficacy. International journal of biological macromolecules. 2024 Jan; 256(Pt 2):128107. doi: 10.1016/j.ijbiomac.2023.128107. [PMID: 38007030]
  • Maria Kopsida, Ada Lerma Clavero, Jaafar Khaled, David Balgoma, Clara Luna-Marco, Azazul Chowdhury, Sofi Sennefelt Nyman, Fredrik Rorsman, Charlotte Ebeling Barbier, Peter Bergsten, Hans Lennernäs, Mikael Hedeland, Femke Heindryckx. Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells. Molecular metabolism. 2024 Jan; 79(?):101846. doi: 10.1016/j.molmet.2023.101846. [PMID: 38030123]
  • Doo Young Lim, Byeong Hee Hwang. Aptamer-modified tetrahedral DNA nanostructure-immobilized liposome for specific gene delivery and potential cancer theragnostic. Biotechnology journal. 2024 Jan; 19(1):e2300156. doi: 10.1002/biot.202300156. [PMID: 37837335]
  • M A Aldubayan, A S Alsharidah, S K Alenezi, A H Alhowail. Galantamine mitigates neurotoxicity caused by doxorubicin via reduced neuroinflammation, oxidative stress, and apoptosis in rat model. European review for medical and pharmacological sciences. 2024 Jan; 28(2):805-813. doi: 10.26355/eurrev_202401_35081. [PMID: 38305623]
  • Jiejie Cai, Jingye Pan. Beta vulgaris-derived exosome-like nanovesicles alleviate chronic doxorubicin-induced cardiotoxicity by inhibiting ferroptosis. Journal of biochemical and molecular toxicology. 2024 Jan; 38(1):e23540. doi: 10.1002/jbt.23540. [PMID: 37728183]
  • Yun Lu, Lan Chen, Zhouxue Wu, Ping Zhou, Jie Dai, Jianmei Li, Qian Wen, Yu Fan, Fancai Zeng, Yue Chen, Shaozhi Fu. Self-driven bioactive hybrids co-deliver doxorubicin and indocyanine green nanoparticles for chemo/photothermal therapy of breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 169(?):115846. doi: 10.1016/j.biopha.2023.115846. [PMID: 37944443]
  • Xiao Mi, Yang Lou, Yutian Wang, Mingran Dong, Hongwei Xue, Shuyang Li, Juan Lu, Xi Chen. Glycyrrhetinic Acid Receptor-Mediated Zeolitic Imidazolate Framework-8 Loaded Doxorubicin as a Nanotherapeutic System for Liver Cancer Treatment. Molecules (Basel, Switzerland). 2023 Dec; 28(24):. doi: 10.3390/molecules28248131. [PMID: 38138618]
  • Guibin Pang, Siqi Wei, Jian Zhao, Fu-Jun Wang. Improving nanochemoimmunotherapy efficacy by boosting "eat-me" signaling and downregulating "don't-eat-me" signaling with Ganoderma lucidum polysaccharide-based drug delivery. Journal of materials chemistry. B. 2023 12; 11(48):11562-11577. doi: 10.1039/d3tb02118a. [PMID: 37982298]
  • Xiaoyu Yang, Chenshuang Zhang, Mingjie Song, Ziru Zhang, Jianping Zhou, Huaqing Zhang, Yang Ding. Enzyme-Silenced Nanosponges Prolong Intratumoral Lifetime to Facilitate Intercellular Relay Drug Delivery and Treatment Efficacy. ACS nano. 2023 Dec; 17(23):23568-23583. doi: 10.1021/acsnano.3c06544. [PMID: 37976418]
  • Ganxiao Chen, Shunxiang Luo, Hongdou Guo, Jiayi Lin, Shanghua Xu. Licochalcone A alleviates ferroptosis in doxorubicin-induced cardiotoxicity via the PI3K/AKT/MDM2/p53 pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Dec; ?(?):. doi: 10.1007/s00210-023-02863-1. [PMID: 38078919]
  • Shuaijun Lu, Hailong Tian, Bowen Li, Lei Li, Hao Jiang, Yajie Gao, Lin Zheng, Canhua Huang, Yuping Zhou, Zhongyan Du, Jia Xu. An Ellagic Acid Coordinated Copper-Based Nanoplatform for Efficiently Overcoming Cancer Chemoresistance by Cuproptosis and Synergistic Inhibition of Cancer Cell Stemness. Small (Weinheim an der Bergstrasse, Germany). 2023 Dec; ?(?):e2309215. doi: 10.1002/smll.202309215. [PMID: 38044295]
  • Xi Chen, Na Lu, Shengbo Huang, Yuanjin Zhang, Zongjun Liu, Xin Wang. Assessment of doxorubicin toxicity using human cardiac organoids: A novel model for evaluating drug cardiotoxicity. Chemico-biological interactions. 2023 Dec; 386(?):110777. doi: 10.1016/j.cbi.2023.110777. [PMID: 37879593]
  • Hailing Tang, Changhui Cao, Guangyuan Zhang, Zhengkao Sun. Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor. Drug delivery. 2023 Dec; 30(1):1-16. doi: 10.1080/10717544.2022.2157519. [PMID: 36644796]
  • Xiujuan Qin, Huiyu Chen, Xiaoli Zhu, Xianjin Xu, Jiarong Gao. Identification of Rab7 as an autophagy marker: potential therapeutic approaches and the effect of Qi Teng Xiao Zhuo granule in chronic glomerulonephritis. Pharmaceutical biology. 2023 Dec; 61(1):1120-1134. doi: 10.1080/13880209.2023.2233998. [PMID: 37477949]
  • Farshid Maleki, Shahram Rabbani, Reza Shirkoohi, Mohsen Rezaei. Allogeneic mitochondrial transplantation ameliorates cardiac dysfunction due to doxorubicin: An in vivo study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115651. doi: 10.1016/j.biopha.2023.115651. [PMID: 37812888]
  • Bidan Zheng, Dongfang Lu, Xiuping Chen, Yinghua Yin, Weiying Chen, Xiaowan Wang, Huanmei Lin, Peng Xu, Aihua Wu, Bo Liu. Tripterygium glycosides improve abnormal lipid deposition in nephrotic syndrome rat models. Renal failure. 2023 Dec; 45(1):2182617. doi: 10.1080/0886022x.2023.2182617. [PMID: 36876728]
  • Omar S Sakr, Mohamed M A Zaitoun, Mohamed S Amer, Mahmoud Qubisi, Ahmed H Elshafeey, Olivier Jordan, Gerrit Borchard. Explosomes: A new modality for DEB-TACE local delivery of sorafenib: In vivo proof of sustained release. Journal of controlled release : official journal of the Controlled Release Society. 2023 12; 364(?):12-22. doi: 10.1016/j.jconrel.2023.10.013. [PMID: 37816482]
  • Antoine Uzel, Leonidas Agiotis, Amélie Baron, Igor V Zhigaltsev, Pieter R Cullis, Morteza Hasanzadeh Kafshgari, Michel Meunier. Single Pulse Nanosecond Laser-Stimulated Targeted Delivery of Anti-Cancer Drugs from Hybrid Lipid Nanoparticles Containing 5 nm Gold Nanoparticles. Small (Weinheim an der Bergstrasse, Germany). 2023 Dec; 19(52):e2305591. doi: 10.1002/smll.202305591. [PMID: 37936336]
  • Lucas E Ribas, Fátima B Gasser, María E Baravalle, Maria S Renna, Adriana Perello, Graciela H Savino, Hugo H Ortega, Franco Van de Velde, Gustavo J Hein. Cytotoxic, antioxidant, and cytoprotective properties of polyphenol-enriched extracts from pecan nutshells in MDA-MB-231 breast cancer cells. Cell biochemistry and function. 2023 Dec; 41(8):1442-1450. doi: 10.1002/cbf.3884. [PMID: 37933894]
  • Haiyun Wang, Junjie Shi, Binbin Tang, Yanfeng Liu, Qili Wang. Forecast and verification of the active compounds and latent targets of Guyuan decoction in treating frequently relapsing nephrotic syndrome based on network pharmacology. Renal failure. 2023 Dec; 45(1):2184654. doi: 10.1080/0886022x.2023.2184654. [PMID: 36866869]
  • Qiyan Chen, Chao Xie, Kaiyue Tang, Mujin Luo, Zhe Zhang, Yabin Jin, Youhua Liu, Lili Zhou, Yaozhong Kong. The E3 ligase Trim63 promotes podocyte injury and proteinuria by targeting PPARα to inhibit fatty acid oxidation. Free radical biology & medicine. 2023 11; 209(Pt 1):40-54. doi: 10.1016/j.freeradbiomed.2023.09.039. [PMID: 37793501]
  • Panpan Tai, Xinyu Chen, Guihua Jia, Guanjun Chen, Lian Gong, Yaxin Cheng, Zhuan Li, Heng Wang, Aiyan Chen, Ganghua Zhang, Yuxing Zhu, Mengqing Xiao, Zhanwang Wang, Yunqing Liu, Dongyong Shan, Dong He, Moying Li, Tianzuo Zhan, Abbas Khan, Xiaohui Li, Xiangxiang Zeng, Chaopeng Li, Dongsheng Ouyang, Kelong Ai, Xuan Chen, Dongbo Liu, Zhonghua Liu, Dongqing Wei, Ke Cao. WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis. Journal of translational medicine. 2023 11; 21(1):823. doi: 10.1186/s12967-023-04715-1. [PMID: 37978379]
  • Izabela Kurowska, Karolina H Markiewicz, Katarzyna Niemirowicz-Laskowska, Mathias Destarac, Przemysław Wielgat, Iwona Misztalewska-Turkowicz, Paweł Misiak, Halina Car, Agnieszka Z Wilczewska. Membrane-Active Thermoresponsive Block Copolymers Containing a Diacylglycerol-Based Segment: RAFT Synthesis, Doxorubicin Encapsulation, and Evaluation of Cytotoxicity against Breast Cancer Cells. Biomacromolecules. 2023 11; 24(11):4854-4868. doi: 10.1021/acs.biomac.3c00580. [PMID: 37842917]
  • Jiongpeng Yuan, Yaoxun Zeng, Zhenxing Pan, ZhenZhen Feng, Ying Bao, Zhaoyi Ye, Yushan Li, Junze Tang, Xujie Liu, Yan He. Amino-Functionalized Zirconium-Based Metal-Organic Frameworks as Bifunctional Nanomaterials to Treat Bone Tumors and Promote Osteogenesis. ACS applied materials & interfaces. 2023 Nov; ?(?):. doi: 10.1021/acsami.3c11787. [PMID: 37943099]
  • Yanyang Li, Lu Fan, Xiaoming Wang, Shichao Lv. Shenmai injection ameliorates doxorubicin-induced myocardial injury by suppressing autophagy-apoptosis via miR-30a. Aging. 2023 11; 15(21):12400-12412. doi: 10.18632/aging.205188. [PMID: 37938165]
  • Ahmad A Altarifi, Kareem Sawali, Karem H Alzoubi, Tareq Saleh, Malik Abu Al-Rub, Omar Khabour. Effect of vitamin E on doxorubicin and paclitaxel-induced memory impairments in male rats. Cancer chemotherapy and pharmacology. 2023 Nov; ?(?):. doi: 10.1007/s00280-023-04602-y. [PMID: 37926754]
  • Yusei Fujioka, Kosuke Otani, Tomoko Kodama, Muneyoshi Okada, Hideyuki Yamawaki. Autocrine role of senescent cardiac fibroblasts-derived extracellular vesicles. The Journal of veterinary medical science. 2023 Nov; 85(11):1157-1164. doi: 10.1292/jvms.23-0279. [PMID: 37779091]
  • Shilong Wu, Qin Zhang, Qiyao Zhao, Yu Jiang, Xiaomeng Qu, Yifan Zhou, Tingting Zhao, Feng Cang, Yanyan Li. Cobalt-doped hollow polydopamine for oxygen generation and GSH consumption enhanced chemo-PTT combined cancer therapy. Biomaterials advances. 2023 Nov; 154(?):213593. doi: 10.1016/j.bioadv.2023.213593. [PMID: 37657278]
  • Ashkan Kalantary-Charvadeh, Saeed Nazari Soltan Ahmad, Somayeh Aslani, Mehdi Beyrami, Mehran Mesgari-Abbasi. β-lapachone protects against doxorubicin-induced hepatotoxicity through modulation of NAD+ /SIRT-1/FXR/p-AMPK/NF-kB and Nrf2 signaling axis. Journal of biochemical and molecular toxicology. 2023 Oct; ?(?):e23564. doi: 10.1002/jbt.23564. [PMID: 37867446]
  • Lili Liu, Meiqi Chang, Rong Yang, Li Ding, Yu Chen, Yulin Kang. Engineering antioxidant ceria-zirconia nanomedicines for alleviating podocyte injury in rats with adriamycin-induced nephrotic syndrome. Journal of nanobiotechnology. 2023 Oct; 21(1):384. doi: 10.1186/s12951-023-02136-2. [PMID: 37858242]
  • Dhaneshvaree Patel, Poonam Yadav, Sumeet K Singh, Sampat S Tanwar, Abhishek Sehrawat, Amit Khurana, Jasvinder S Bhatti, Umashanker Navik. Betaine alleviates doxorubicin-induced nephrotoxicity by preventing oxidative insults, inflammation, and fibrosis through the modulation of Nrf2/HO-1/NLRP3 and TGF-β expression. Journal of biochemical and molecular toxicology. 2023 Oct; ?(?):e23559. doi: 10.1002/jbt.23559. [PMID: 37840533]
  • Ahmad H Alhowail. Pioglitazone ameliorates DOX-induced cognitive impairment by mitigating inflammation, oxidative stress, and apoptosis of hippocampal neurons in rats. Behavioural brain research. 2023 Oct; ?(?):114714. doi: 10.1016/j.bbr.2023.114714. [PMID: 37838244]
  • Shiva Falahianshafiei, Javad Akhtari, Ali Davoodi, Hajar Pasha. Evaluation of anticancer effect of colchicum autumnale L. Corm on breast cancer cell. BMC complementary medicine and therapies. 2023 Oct; 23(1):357. doi: 10.1186/s12906-023-04189-0. [PMID: 37805533]