Parathion (BioDeep_00000001403)
Secondary id: BioDeep_00000229711, BioDeep_00001867643
human metabolite Endogenous Industrial Pollutants
代谢物信息卡片
p-Nitrophenol O-ester with O,O-diethylphosphorothioic acid
化学式: C10H14NO5PS (291.033)
中文名称: 巴拉松, 对硫磷
谱图信息:
最多检出来源 Homo sapiens(natural_products) 8.4%
分子结构信息
SMILES: CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]
InChI: InChI=1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
描述信息
Parathion is a highly toxic cholinesterase inhibitor that is used as an acaricide and as an insecticide.
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
A highly toxic cholinesterase inhibitor that is used as an acaricide and as an insecticide. [HMDB]
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D010575 - Pesticides > D007306 - Insecticides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals
同义名列表
119 个代谢物同义名
p-Nitrophenol O-ester with O,O-diethylphosphorothioic acid; Ethyl parathion (O,O-diethyl-O-p-nitrophenylthiophosphate); Phosphorothioic acid, O,O-diethyl O-(4-nitrophenyl) ester; Phosphorothioic acid O,O-diethyl-O-(4-nitrophenyl) ester; p-Nitrophenol O-ester with O,O-diethylphosphorothioate; Phosphorothioate, O,O-diethyl O-(4-nitrophenyl) ester; O,O-Diethyl O-(4-nitrophenyl) thiophosphoric acid; O,O-Diethyl O-(p-nitrophenyl) thiophosphoric acid; O,O-Diethyl O-p-nitrophenyl phosphorothioic acid; O,O-Diethyl-O-(p-nitrophenyl)thionophosphate; O,O-diethyl O-4-nitrophenyl phosphorothioate; Diethyl O-p-nitrophenyl phosphorothioic acid; O,O-Diethyl O-p-nitrophenyl phosphorothioate; O,O-Diethyl O-(4-nitrophenyl) thiophosphate; O,O-Diethyl O-(p-nitrophenyl) thiophosphate; Diethyl p-nitrophenyl thiophosphoric acid; Diethyl O-p-nitrophenyl phosphorothioate; Diethyl-p-nitrophenyl monothiophosphate; Diethyl 4-nitrophenyl phosphorothionate; Diethyl para-nitrophenol thiophosphate; Diethyl p-nitrophenyl thionophosphate; Diethyl p-nitrophenyl thiophosphate; Deoxynucleoside 5-triphosphate; Stabilized ethyl parathion; Sixty-three special e.c; American cyanamid 3422; dibutyl butanedioate; Phosphorothioic acid; Drexel parathion 8E; Diethyl parathion; Thionspray no.84; Aqua 9-parathion; Phosphorothioate; diethyl p-nitrop; Diethylparathion; Parathion, ethyl; Lethalaire g-54; Folidol e e 605; Phosphostigmine; Ethyl parathion; Super rodiatox; Thiophos 3422; Oleoparaphene; Oleoparathion; Nitrostygmine; Folidol e605; Folidol oil; Pestox plus; Fosferno 50; Parathion-e; Paramar 50; Phosphenol; Soprathion; Rhodiatrox; Phosphemol; Oleofos 20; Nourithion; Rhodiasol; Rhodiatox; parathion; Orthophos; Corthione; Strathion; Parathene; Lirothion; Penncap e; Genithion; Corothion; Niuif-100; Durathion; Panthion; Paraphos; Thiophos; Parthion; Gearphos; Stathion; Aphamite; Foliclal; Fosfermo; Danthion; Selephos; Fosferno; Kypthion; Paradust; Vapophos; Phoskil; Paramar; Pethion; Folidol; Fostern; Kolphos; Parawet; Alleron; Thiofos; Thiomex; Fosfive; Ecatox; Bladen; OMS 19; Fosfex; Sulfos; Etilon; Ethlon; Vitrex; Tiofos; Bladan; Fosova; Fostox; Alkron; Murfos; Niran; Pacol; Viran; Aralo; DNTP; T-47; PAC; PAT; Parathion
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:27928
- KEGG: C06604
- PubChem: 8830
- PubChem: 991
- HMDB: HMDB0001355
- Metlin: METLIN58039
- ChEMBL: CHEMBL261919
- Wikipedia: Parathion
- MeSH: Parathion
- foodb: FDB022574
- chemspider: 13844817
- CAS: 56-38-2
- PMhub: MS000000451
- PDB-CCD: WYS
- NIKKAJI: J2.318C
- RefMet: Parathion
- KNApSAcK: 27928
- LOTUS: LTS0167693
- wikidata: Q412556
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
11 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(11)
- superpathway of parathion degradation:
H+ + e- + parathion ⟶ H2O + amino-parathion - superpathway of parathion degradation:
H+ + e- + parathion ⟶ H2O + amino-parathion - parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate - parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate - parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate - parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate - parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate - parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate - superpathway of parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate - parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate - parathion degradation:
H2O + parathion ⟶ 4-nitrophenol + H+ + diethylthiophosphate
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Valéria Costa Da Silva, Gerlane Coelho Bernardo Guerra, Daline Fernandes De Souza Araújo, Edilane Rodrigues De Araújo, Aurigena Antunes De Araújo, Renato Dantas-Medeiros, Ana Caroline Zanatta, Isadora Luisa Gomes Da Silva, Raimundo Fernandes De Araújo Júnior, Debora Esposito, Marvin Moncada, Silvana Maria Zucolotto. Chemopreventive and immunomodulatory effects of phenolic-rich extract of Commiphora leptophloeos against inflammatory bowel disease: Preclinical evidence.
Journal of ethnopharmacology.
2024 Jun; 328(?):118025. doi:
10.1016/j.jep.2024.118025. [PMID: 38458342] - Stefania Lama, Ester Pagano, Francesca Borrelli, Maria Maisto, Gian Carlo Tenore, Maria Francesca Nanì, Pilar Chacon-Millan, Ettore Novellino, Paola Stiuso. Polyphenol-Rich Extract from 'Limoncella' Apple Variety Ameliorates Dinitrobenzene Sulfonic Acid-Induced Colitis and Linked Liver Damage.
International journal of molecular sciences.
2024 Mar; 25(6):. doi:
10.3390/ijms25063210. [PMID: 38542183] - Tommaso Venneri, Giada Giorgini, Nadine Leblanc, Nicolas Flamand, Francesca Borrelli, Cristoforo Silvestri, Vincenzo Di Marzo. Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice.
Lipids in health and disease.
2023 May; 22(1):63. doi:
10.1186/s12944-023-01823-1. [PMID: 37189092] - Saroj K Amar, Keri B Donohue, Kurt A Gust. Cellular and molecular responses to ethyl-parathion in undifferentiated SH-SY5Y cells provide neurotoxicity pathway indicators for organophosphorus impacts.
Toxicological sciences : an official journal of the Society of Toxicology.
2023 Feb; 191(2):285-295. doi:
10.1093/toxsci/kfac125. [PMID: 36458919] - José R Cruz-Muñoz, Tonatiuh Barrios-García, Eduardo E Valdez-Morales, María F Durán-Vazquez, Karen B Méndez-Rodríguez, Alma Barajas-Espinosa, Fernando Ochoa-Cortes, María C Martínez-Saldaña, Yenny A Gómez-Aguirre, Raquel Guerrero Alba. Ethanolic extract from Lepidium virginicum L. ameliorates DNBS-induced colitis in rats.
Journal of ethnopharmacology.
2022 May; 289(?):115056. doi:
10.1016/j.jep.2022.115056. [PMID: 35104576] - Kelin Tao, Haixia Tian, Jing Fan, Dongxiao Li, Chaoyang Liu, Mallavarapu Megharaj, Huayong Li, Min Hu, Hanzhong Jia, Wenxiang He. Kinetics and catalytic efficiency of soil fluorescein diacetate hydrolase under the pesticide parathion stress.
The Science of the total environment.
2021 Jun; 771(?):144835. doi:
10.1016/j.scitotenv.2020.144835. [PMID: 33548707] - Emiliano Manzo, Aniello Schiano Moriello, Francesco Tinto, Roberta Verde, Marco Allarà, Luciano De Petrocellis, Ester Pagano, Angelo A Izzo, Vincenzo Di Marzo, Stefania Petrosino. A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator.
Cells.
2021 02; 10(2):. doi:
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Pesticide biochemistry and physiology.
2021 Feb; 172(?):104747. doi:
10.1016/j.pestbp.2020.104747. [PMID: 33518056] - Carmen Parisio, Elena Lucarini, Laura Micheli, Alessandra Toti, Maria Bellumori, Lorenzo Cecchi, Laura Calosi, Daniele Bani, Lorenzo Di Cesare Mannelli, Nadia Mulinacci, Carla Ghelardini. Extra virgin olive oil and related by-products (Olea europaea L.) as natural sources of phenolic compounds for abdominal pain relief in gastrointestinal disorders in rats.
Food & function.
2020 Dec; 11(12):10423-10435. doi:
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Chemosphere.
2020 Aug; 253(?):126679. doi:
10.1016/j.chemosphere.2020.126679. [PMID: 32283425] - Lindsay M Jaacks, Nancy Diao, Antonia M Calafat, Maria Ospina, Maitreyi Mazumdar, Md Omar Sharif Ibne Hasan, Robert Wright, Quazi Quamruzzaman, David C Christiani. Association of prenatal pesticide exposures with adverse pregnancy outcomes and stunting in rural Bangladesh.
Environment international.
2019 12; 133(Pt B):105243. doi:
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Journal of neuroimmunology.
2019 01; 326(?):79-83. doi:
10.1016/j.jneuroim.2018.11.011. [PMID: 30544018] - Valéria Costa da Silva, Aurigena Antunes de Araújo, Daline Fernandes de Souza Araújo, Maíra Conceição Jerônimo Souza Lima, Roseane Carvalho Vasconcelos, Raimundo Fernandes de Araújo Júnior, Silvana Maria Zucolotto Langasnner, Matheus de Freitas Fernandes Pedrosa, Caroline Addison Carvalho Xavier de Medeiros, Gerlane Coelho Bernardo Guerra. Intestinal Anti-Inflammatory Activity of the Aqueous Extract from Ipomoea asarifolia in DNBS-Induced Colitis in Rats.
International journal of molecular sciences.
2018 Dec; 19(12):. doi:
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Food chemistry.
2018 Jul; 255(?):104-111. doi:
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Gene.
2018 Jul; 663(?):131-137. doi:
10.1016/j.gene.2018.04.031. [PMID: 29680247] - Haina Sun, Nicolas Buchon, Jeffrey G Scott. Mdr65 decreases toxicity of multiple insecticides in Drosophila melanogaster.
Insect biochemistry and molecular biology.
2017 10; 89(?):11-16. doi:
10.1016/j.ibmb.2017.08.002. [PMID: 28803989] - Jing Bao, Changjun Hou, Qiuchen Dong, Xiaoyu Ma, Jun Chen, Danqun Huo, Mei Yang, Khaled Hussein Abd El Galil, Wilfred Chen, Yu Lei. ELP-OPH/BSA/TiO2 nanofibers/c-MWCNTs based biosensor for sensitive and selective determination of p-nitrophenyl substituted organophosphate pesticides in aqueous system.
Biosensors & bioelectronics.
2016 Nov; 85(?):935-942. doi:
10.1016/j.bios.2016.05.094. [PMID: 27315519] - Marika Cordaro, Daniela Impellizzeri, Enrico Gugliandolo, Rosalba Siracusa, Rosalia Crupi, Emanuela Esposito, Salvatore Cuzzocrea. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease.
Molecular pharmacology.
2016 Nov; 90(5):549-561. doi:
10.1124/mol.116.105668. [PMID: 27625036] - Noureddine Bribi, Francesca Algieri, Alba Rodriguez-Nogales, Teresa Vezza, Jose Garrido-Mesa, María Pilar Utrilla, María Del Mar Contreras, Fadila Maiza, Antonio Segura-Carretero, Maria Elena Rodriguez-Cabezas, Julio Gálvez. Intestinal anti-inflammatory effects of total alkaloid extract from Fumaria capreolata in the DNBS model of mice colitis and intestinal epithelial CMT93 cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2016 Aug; 23(9):901-13. doi:
10.1016/j.phymed.2016.05.003. [PMID: 27387398] - Erin Gallagher, Il Minn, Janice E Chambers, Peter C Searson. In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs).
Fluids and barriers of the CNS.
2016 Jul; 13(1):10. doi:
10.1186/s12987-016-0035-0. [PMID: 27396356] - Haiyan Shi, Enze Sheng, Lu Feng, Liangliang Zhou, Xiude Hua, Minghua Wang. Simultaneous detection of imidacloprid and parathion by the dual-labeled time-resolved fluoroimmunoassay.
Environmental science and pollution research international.
2015 Oct; 22(19):14882-90. doi:
10.1007/s11356-015-4697-y. [PMID: 25994268] - Jing Liu, Loren Parsons, Carey Pope. Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum.
Neurotoxicology.
2015 Sep; 50(?):20-7. doi:
10.1016/j.neuro.2015.07.006. [PMID: 26215119] - Nidhi Goyal, Ajay Rana, Krishna Reddy V Bijjem, Puneet Kumar. Effect of chenodeoxycholic acid and sodium hydrogen sulfide in dinitro benzene sulfonic acid (DNBS)--Induced ulcerative colitis in rats.
Pharmacological reports : PR.
2015 Jun; 67(3):616-23. doi:
10.1016/j.pharep.2014.12.018. [PMID: 25933978] - Wei Wang, Si-Lu Liu, Yang-Yang Liu, Chuan-Ling Qiao, Shao-Liang Chen, Feng Cui. Over-transcription of genes in a parathion-resistant strain of mosquito Culex pipiens quinquefasciatus.
Insect science.
2015 Feb; 22(1):150-6. doi:
10.1111/1744-7917.12106. [PMID: 24431295] - Wen S Lan, Ti K Lu, Zhi F Qin, Xiu J Shi, Jin J Wang, Yun F Hu, Bin Chen, Yi H Zhu, Zheng Liu. Genetically modified microorganism Spingomonas paucimobilis UT26 for simultaneously degradation of methyl-parathion and γ-hexachlorocyclohexane.
Ecotoxicology (London, England).
2014 Jul; 23(5):840-50. doi:
10.1007/s10646-014-1224-8. [PMID: 24648032] - Vijay Morampudi, Ganive Bhinder, Xiujuan Wu, Chuanbin Dai, Ho Pan Sham, Bruce A Vallance, Kevan Jacobson. DNBS/TNBS colitis models: providing insights into inflammatory bowel disease and effects of dietary fat.
Journal of visualized experiments : JoVE.
2014 Feb; ?(84):e51297. doi:
10.3791/51297. [PMID: 24637969] - Xiangjiang Tang, Bo Liang, Tuyong Yi, Giuseppe Manco, Ilaria Palchetti, Ilariapalchetti, Aihua Liu. Cell surface display of organophosphorus hydrolase for sensitive spectrophotometric detection of p-nitrophenol substituted organophosphates.
Enzyme and microbial technology.
2014 Feb; 55(?):107-12. doi:
10.1016/j.enzmictec.2013.10.006. [PMID: 24411452] - Isabelle Olivier, Vassilia Theodorou, Philippe Valet, Isabelle Castan-Laurell, Laurent Ferrier, Hélène Eutamène. Modifications of mesenteric adipose tissue during moderate experimental colitis in mice.
Life sciences.
2014 Jan; 94(1):1-7. doi:
10.1016/j.lfs.2013.09.028. [PMID: 24215755] - Th Zilker. [Acute intoxication in adults - what you should know].
Deutsche medizinische Wochenschrift (1946).
2014 Jan; 139(1-2):31-46; quiz 43. doi:
10.1055/s-0033-1359902. [PMID: 24390849] - Issam Ben Salem, Sana Fekih, Haitham Sghaier, Mehrez Bousselmi, Mouldi Saidi, Ahmed Landoulsi, Sami Fattouch. Effect of ionising radiation on polyphenolic content and antioxidant potential of parathion-treated sage (Salvia officinalis) leaves.
Food chemistry.
2013 Nov; 141(2):1398-405. doi:
10.1016/j.foodchem.2013.04.008. [PMID: 23790930] - R Nishino, T Fukuyama, Y Tajima, L Miyashita, Y Watanabe, H Ueda, T Kosaka. Prior oral exposure to environmental immunosuppressive chemicals methoxychlor, parathion, or piperonyl butoxide aggravates allergic airway inflammation in NC/Nga mice.
Toxicology.
2013 Jul; 309(?):1-8. doi:
10.1016/j.tox.2013.03.018. [PMID: 23583882] - Riccardo Funari, Bartolomeo Della Ventura, Luigi Schiavo, Rosario Esposito, Carlo Altucci, Raffaele Velotta. Detection of parathion pesticide by quartz crystal microbalance functionalized with UV-activated antibodies.
Analytical chemistry.
2013 Jul; 85(13):6392-7. doi:
10.1021/ac400852c. [PMID: 23721081] - Falicia L Edwards, Clement G Yedjou, Paul B Tchounwou. Involvement of oxidative stress in methyl parathion and parathion-induced toxicity and genotoxicity to human liver carcinoma (HepG₂) cells.
Environmental toxicology.
2013 Jun; 28(6):342-8. doi:
10.1002/tox.20725. [PMID: 21544925] - D Strøbæk, D T Brown, D P Jenkins, Y-J Chen, N Coleman, Y Ando, P Chiu, S Jørgensen, J Demnitz, H Wulff, P Christophersen. NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.
British journal of pharmacology.
2013 Jan; 168(2):432-44. doi:
10.1111/j.1476-5381.2012.02143.x. [PMID: 22891655] - Helena Shifrin, Mirela Nadler-Milbauer, Shai Shoham, Marta Weinstock. Rivastigmine alleviates experimentally induced colitis in mice and rats by acting at central and peripheral sites to modulate immune responses.
PloS one.
2013; 8(2):e57668. doi:
10.1371/journal.pone.0057668. [PMID: 23469045] - T Fukuyama, T Kosaka, L Miyashita, R Nishino, K Wada, K Hayashi, H Ueda, T Harada. Role of regulatory T cells in the induction of atopic dermatitis by immunosuppressive chemicals.
Toxicology letters.
2012 Sep; 213(3):392-401. doi:
10.1016/j.toxlet.2012.07.018. [PMID: 22842586] - Jean-Louis Mariage, Anja Gallinat, Philippe Hantson. Organ donation following fatal organophosphate poisoning.
Transplant international : official journal of the European Society for Organ Transplantation.
2012 Jun; 25(6):e71-2. doi:
10.1111/j.1432-2277.2012.01466.x. [PMID: 22443143] - Alejandro A Canales-Aguirre, Ulises A Gomez-Pinedo, Sonia Luquin, Mario A Ramírez-Herrera, María L Mendoza-Magaña, Alfredo Feria-Velasco. Curcumin protects against the oxidative damage induced by the pesticide parathion in the hippocampus of the rat brain.
Nutritional neuroscience.
2012 Mar; 15(2):62-9. doi:
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Chemico-biological interactions.
2012 Feb; 195(3):189-98. doi:
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The protein journal.
2012 Feb; 31(2):120-8. doi:
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TheScientificWorldJournal.
2012; 2012(?):627607. doi:
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Toxicology.
2011 Nov; 289(2-3):132-40. doi:
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Toxicology and applied pharmacology.
2011 Sep; 255(2):214-20. doi:
10.1016/j.taap.2011.06.021. [PMID: 21767560] - Robert J Foxenberg, Corie A Ellison, James B Knaak, Changxing Ma, James R Olson. Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion.
Toxicology.
2011 Jul; 285(1-2):57-66. doi:
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Toxicology.
2011 Feb; 280(3):77-87. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2010 Dec; 299(6):G1376-85. doi:
10.1152/ajpgi.00258.2010. [PMID: 20864654] - T Leon Lassiter, Ian T Ryde, Edward D Levin, Frederic J Seidler, Theodore A Slotkin. Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits.
Brain research bulletin.
2010 Jan; 81(1):85-91. doi:
10.1016/j.brainresbull.2009.07.002. [PMID: 19615431] - Theodore A Slotkin, Nicola Wrench, Ian T Ryde, T Leon Lassiter, Edward D Levin, Frederic J Seidler. Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood.
Neurotoxicology and teratology.
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