1,1-Dimethylbiguanide (BioDeep_00000001376)
Secondary id: BioDeep_00000229722, BioDeep_00000397913
natural product human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs
描述信息
1,1-Dimethylbiguanide, commonly known as metformin, is a member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1. It has a role as a hypoglycemic agent, a xenobiotic and an environmental contaminant. It derives from a biguanide. It is a conjugate base of a metformin(1+). Metformin is a biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. Metformin is the most popular anti-diabetic drug in the United States and one of the most prescribed drugs in the country overall, with nearly 35 million prescriptions filled in 2006 for generic metformin alone. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain and is taken by mouth. It is sometimes used as an off-label augment to attenuate the risk of weight gain in people who take antipsychotics as well as phenelzine.
1,1-Dimethylbiguanide or Metformin is a biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. Metformin is the most popular anti-diabetic drug in the United States and one of the most prescribed drugs in the country overall, with nearly 35 million prescriptions filled in 2006 for generic metformin alone. [HMDB]
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BA - Biguanides
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98234 - Biguanide Antidiabetic Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D007004 - Hypoglycemic Agents > D001645 - Biguanides
CONFIDENCE standard compound; INTERNAL_ID 4124
CONFIDENCE standard compound; INTERNAL_ID 8678
CONFIDENCE standard compound; INTERNAL_ID 1127
C1892 - Chemopreventive Agent
KEIO_ID M032
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin can cross the blood-brain barrier and triggers autophagy[1].
同义名列表
38 个代谢物同义名
1-carbamimidamido-N,N-dimethylmethanimidamide; N,N-Dimethylimidodicarbonimidic diamide; 1,1-Dimethylbiguanide hydrochloride; N(1),N(1)-Dimethylbiguanide; N,N-Dimethylguanylguanidine; Hydrochloride, metformin; N1,N1-Dimethylbiguanide; Metformin hydrochloride; Dimethylguanylguanidine; 1,1-Dimethyl biguanide; 1,1-Dimethylbiguanide; N,N-Dimethyldiguanide; N,N-Dimethylbiguanide; Dimethylbiguanidine; Dimethyldiguanide; Dimethylbiguanide; HCL, Metformin; Metformin HCL; Metforminum; Metiguanide; Metformina; Metformine; Diabefagos; Glucophage; Diaformin; metformin; Glumetza; Fortamet; LA-6023; Dianben; LA 6023; Diabex; Meguan; Riomet; Obimet; DMBG; Metformin; Metformin
数据库引用编号
38 个数据库交叉引用编号
- ChEBI: CHEBI:6801
- KEGG: C07151
- KEGGdrug: D72476
- KEGGdrug: D04966
- PubChem: 4091
- HMDB: HMDB0001921
- Metlin: METLIN1180
- DrugBank: DB00331
- ChEMBL: CHEMBL1431
- Wikipedia: Metformin
- MeSH: Metformin
- foodb: FDB022739
- chemspider: 3949
- CAS: 657-24-9
- MoNA: UF412404
- MoNA: UF412402
- MoNA: PS002205
- MoNA: KO003376
- MoNA: PS002203
- MoNA: UF412403
- MoNA: KO003375
- MoNA: UF412401
- MoNA: KO003372
- MoNA: AU112703
- MoNA: PS002201
- MoNA: AU112701
- MoNA: SM867803
- MoNA: KO003374
- MoNA: KO003373
- MoNA: PS002202
- MoNA: AU112702
- MoNA: PS002204
- PMhub: MS000000411
- PubChem: 9360
- PDB-CCD: MF8
- NIKKAJI: J9.463C
- medchemexpress: HY-B0627
- KNApSAcK: 6801
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaodan Chen, Faranak Bahramimehr, Nasim Shahhamzehei, Huangjie Fu, Siyi Lin, Hanxiao Wang, Changyu Li, Thomas Efferth, Chunlan Hong. Anti-aging effects of medicinal plants and their rapid screening using the nematode Caenorhabditis elegans.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155665. doi:
10.1016/j.phymed.2024.155665. [PMID: 38768535] - Erin Ussery, Mark McMaster, Vince Palace, Joanne Parrott, Nicholas C Blandford, Richard Frank, Karen Kidd, Oana Birceanu, Joanna Wilson, Mehran Alaee, Jessie Cunningham, Abby Wynia, Thomas Clark, Sheena Campbell, Lauren Timlick, Sonya Michaleski, Stephanie Marshall, Kristin Nielsen. Effects of metformin on wild fathead minnows (Pimephales promelas) using in-lake mesocosms in a boreal lake ecosystem.
The Science of the total environment.
2024 Jun; 929(?):172457. doi:
10.1016/j.scitotenv.2024.172457. [PMID: 38649046] - Soo Lim, Seung-Hwan Lee, Kyung-Wan Min, Chang Beom Lee, Sang Yong Kim, Hye Jin Yoo, Nan Hee Kim, Jae Hyeon Kim, Seungjoon Oh, Jong Chul Won, Hyuk Sang Kwon, Mi Kyung Kim, Jung Hwan Park, In-Kyung Jeong, Sungrae Kim. A multicentre, double-blind, placebo-controlled, randomized, parallel comparison, phase 3 trial to evaluate the efficacy and safety of pioglitazone add-on therapy in type 2 diabetic patients treated with metformin and dapagliflozin.
Diabetes, obesity & metabolism.
2024 Jun; 26(6):2188-2198. doi:
10.1111/dom.15526. [PMID: 38425186] - Yaotian Cai, Gao Jun, Xiaojie Zhuang. Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2024 Jun; 35(6):1089-1098. doi:
10.1007/s00198-023-07013-0. [PMID: 38536446] - Sriravali Pulipaka, Hridya Chempon, Gajalakshmi Singuru, Shashikanta Sahoo, Altab Shaikh, Sunita Kumari, Rajamannar Thennati, Srigiridhar Kotamraju. Mitochondria-targeted esculetin and metformin delay endothelial senescence by promoting fatty acid β-oxidation: Relevance in age-associated atherosclerosis.
Mechanisms of ageing and development.
2024 Jun; 219(?):111931. doi:
10.1016/j.mad.2024.111931. [PMID: 38554949] - Qian Yang, Mohammed Abed Jawad, Abdullah Ali Alzahrani, Zahraa F Hassan, Ahmed Elawady, Ahmed Hjazi, Mehran Naghibi. Synergistic effects of Metformin and Forskolin on oxidative stress induced by diabetes and hepatocellular cancer: An animal study.
Toxicon : official journal of the International Society on Toxinology.
2024 May; 243(?):107720. doi:
10.1016/j.toxicon.2024.107720. [PMID: 38614244] - Diana Belen Onofre-Camarena, Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez-Oliván, Sandra García-Medina, Marcela Galar-Martínez, José Roberto Jerónimo Juárez, Selene Elizabeth Herrera-Vázquez. Assessing the impact of COVID-19 era drug combinations on hepatic functionality: A thorough investigation in adult Danio rerio.
Environmental pollution (Barking, Essex : 1987).
2024 May; 349(?):123997. doi:
10.1016/j.envpol.2024.123997. [PMID: 38636837] - Guillem Cuatrecasas, Francisco De Cabo, M José Coves, Ioana Patrascioiu, Gerardo Aguilar, Gabriel Cuatrecasas, Sonia March, Marta Calbo, Olga Rossell, Mariona Balfegó, Camila Benito, Silvana Di Gregorio, Pilar Garcia Lorda, Elena Muñoz. Dapagliflozin added to metformin reduces perirenal fat layer in type 2 diabetic patients with obesity.
Scientific reports.
2024 05; 14(1):10832. doi:
10.1038/s41598-024-61590-6. [PMID: 38734755] - Grace Scheidemantle, Likun Duan, Mareca Lodge, Magdalina J Cummings, Dalton Hilovsky, Eva Pham, Xiaoqiu Wang, Arion Kennedy, Xiaojing Liu. Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism.
Metabolomics : Official journal of the Metabolomic Society.
2024 May; 20(3):53. doi:
10.1007/s11306-024-02113-2. [PMID: 38722395] - Yangchen Tang, Mengli Yan, Zemin Fang, Song Jin, Tingjuan Xu. Effects of metformin, saxagliptin and repaglinide on gut microbiota in high-fat diet/streptozocin-induced type 2 diabetic mice.
BMJ open diabetes research & care.
2024 May; 12(3):. doi:
10.1136/bmjdrc-2023-003837. [PMID: 38719505] - Nesma A Ghazal, Yara T Agamia, Basant K Meky, Nagwa M Assem, Wafaa M Abdel-Rehim, Sara A Shaker. Cinnamaldehyde ameliorates STZ-induced diabetes through modulation of autophagic process in adipocyte and hepatic tissues on rats.
Scientific reports.
2024 05; 14(1):10053. doi:
10.1038/s41598-024-60150-2. [PMID: 38698047] - Anthony J Basile, Avin Kreisler, Ryan Hassen, Kavita Singh, Maggie Symes, Gale Larson, Milena Figueiredo de Sousa, Karen L Sweazea. Acute metformin induces hyperglycemia in healthy adult mourning doves, Zenaida macroura.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2024 05; 291(?):111594. doi:
10.1016/j.cbpa.2024.111594. [PMID: 38311294] - Jiao Liu, Lixia Shen, Long Nguyen-Hoang, Qiongjie Zhou, Chi Chiu Wang, Xiaohong Lu, Daljit Sahota, Ka Chun Chong, Hao Ying, Weirong Gu, Rong Zhou, Huixia Yang, Yanmin Jiang, Dunjin Chen, Xiaotian Li, Liona Poon. Aspirin versus metformin in pregnancies at high risk of preterm pre-eclampsia in China (AVERT): protocol for a multicentre, double-blind, 3-arm randomised controlled trial.
BMJ open.
2024 Apr; 14(4):e074493. doi:
10.1136/bmjopen-2023-074493. [PMID: 38631826] - Saif Alnuaimi, Tea Reljic, Fatima S Abdulla, Hamda Memon, Sarah Al-Ali, Teagen Smith, Fadila Serdarevic, Zelija Velija Asimi, Ambuj Kumar, Sabina Semiz. PPAR agonists as add-on treatment with metformin in management of type 2 diabetes: a systematic review and meta-analysis.
Scientific reports.
2024 04; 14(1):8809. doi:
10.1038/s41598-024-59390-z. [PMID: 38627464] - Lei Dong, Shuai Li, Jie Huang, Wen-Jun Li, Mukhtiar Ali. Co-occurrence, toxicity, and biotransformation pathways of metformin and its intermediate product guanylurea: Current state and future prospects for enhanced biodegradation strategy.
The Science of the total environment.
2024 Apr; 921(?):171108. doi:
10.1016/j.scitotenv.2024.171108. [PMID: 38395159] - Manuel Adrían Velazquez-Cervantes, Orestes López-Ortega, Victor Javier Cruz-Holguín, Luis Herrera Moro-Huitron, Arturo Flores-Pliego, Ignacio Lara-Hernandez, Mauricio Comas-García, Oscar Villavicencio-Carrisoza, Addy Cecilia Helguera-Reppeto, Haruki Arévalo-Romero, Edgar Ricardo Vázquez-Martínez, Moises León-Juárez. Metformin Inhibits Zika Virus Infection in Trophoblast Cell Line.
Current microbiology.
2024 Apr; 81(5):133. doi:
10.1007/s00284-024-03651-7. [PMID: 38592489] - Asmaa Badawy Darwish, Amira Mohamed Mohsen, Shaimaa ElShebiney, Rania Elgohary, Mostafa Mohamed Younis. Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats.
Scientific reports.
2024 04; 14(1):8247. doi:
10.1038/s41598-024-58601-x. [PMID: 38589438] - Runan Hu, Yanjing Huang, Yuli Geng, Zhuo Liu, Fan Li, Zhuo Zhang, Wenwen Ma, Kunkun Song, Haoxu Dong, Yufan Song, Mingmin Zhang. Jiawei Buzhong Yiqi decoction ameliorates polycystic ovary syndrome via oocyte-granulosa cell communication.
Journal of ethnopharmacology.
2024 Apr; 323(?):117654. doi:
10.1016/j.jep.2023.117654. [PMID: 38158097] - Jinhui Dong, Xiaohui Tong, Jing Xu, Min Pan, Lei Wang, Fei Xu, Yajuan Wang, Li Li, Tongsheng Wang. Metformin improves obesity-related oligoasthenospermia via regulating the expression of HSL in testis in mice.
European journal of pharmacology.
2024 Apr; 968(?):176388. doi:
10.1016/j.ejphar.2024.176388. [PMID: 38367685] - Shuying Jiang, Ruiqian Wang, Jian Liao. The Role of Metformin in Overactive Bladder: More Studies Are Warranted.
Urology.
2024 04; 186(?):144-145. doi:
10.1016/j.urology.2023.11.038. [PMID: 38369200] - Yang Shu, Fujie Yang, Weidong Li, Lisha Li, Qiongying Hu, Daqian Xiong. Changes and Significance of Central Carbon Metabolism before and after Metformin Treatment of Type 2 Diabetes Based on Mass Spectrometry.
Discovery medicine.
2024 Apr; 36(183):678-689. doi:
10.24976/discov.med.202436183.64. [PMID: 38665017] - Shahinaz Ahmed Helmy, Nashwa Fathy Sayed Morsy, Shahenda Mohamed Elaby, Mohammed Abdel Hameed Awad Ghaly. Antidiabetic Effect of Combined Leaf Extracts of Portulaca oleracea L., Beta vulgaris L., and Cichorium intybus L. in Streptozotocin-Induced Diabetic Rats.
Journal of medicinal food.
2024 Apr; 27(4):339-347. doi:
10.1089/jmf.2022.0119. [PMID: 37801671] - Teng Zhang, Meng-Yan Wang, Guo-Dong Wang, Qiu-Yue Lv, Yu-Qian Huang, Peng Zhang, Wen Wang, Yan Zhang, Ya-Ping Bai, Li-Qun Guo. Metformin improves nonalcoholic fatty liver disease in db/db mice by inhibiting ferroptosis.
European journal of pharmacology.
2024 Mar; 966(?):176341. doi:
10.1016/j.ejphar.2024.176341. [PMID: 38244761] - Saja Majeed Shareef, Raghad Abdulsalam Khaleel, Taif M Maryoosh. Nephroprotective effect of cranberry (Vaccinium oxycoccos) in streptozocin-induced diabetic nephropathy in mice.
Drug metabolism and personalized therapy.
2024 Mar; 39(1):35-45. doi:
10.1515/dmpt-2023-0092. [PMID: 38469711] - Seung-Ju Hwang, Yu-Jin Choi, Jing-Hua Wang, Chang-Gue Son. Lactobacillus Casei-fermented Amomum Xanthioides Mitigates non-alcoholic fatty liver disease in a high-fat diet mice model.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Mar; 172(?):116250. doi:
10.1016/j.biopha.2024.116250. [PMID: 38320334] - Anna Evelin Juhász, Márton Péter Stubnya, Brigitta Teutsch, Noémi Gede, Péter Hegyi, Péter Nyirády, Ferenc Bánhidy, Nándor Ács, Réka Juhász. Ranking the dietary interventions by their effectiveness in the management of polycystic ovary syndrome: a systematic review and network meta-analysis.
Reproductive health.
2024 Feb; 21(1):28. doi:
10.1186/s12978-024-01758-5. [PMID: 38388374] - Arash Bahramzadeh, Sadra Samavarchi Tehrani, Golnaz Goodarzi, ShadiSadat Seyyedebrahimi, Reza Meshkani. Combination therapy of metformin and morin attenuates insulin resistance, inflammation, and oxidative stress in skeletal muscle of high-fat diet-fed mice.
Phytotherapy research : PTR.
2024 Feb; 38(2):912-924. doi:
10.1002/ptr.8086. [PMID: 38091524] - Debasish Hota, Biswa M Padhy, Rituparna Maiti, Debasis Bisoi, Jyoti Prakash Sahoo, Binod K Patro, Pawan Kumar, Apurva Goel, Samudra P Banik, Sanjoy Chakraborty, Mehul Rungta, Manashi Bagchi, Debasis Bagchi. A Placebo-Controlled, Double-Blind Clinical Investigation to Evaluate the Efficacy of a Patented Trigonella foenum-graecum Seed Extract 'Fenfuro®' in Type 2 Diabetics.
Journal of the American Nutrition Association.
2024 Feb; 43(2):147-156. doi:
10.1080/27697061.2023.2233008. [PMID: 37459747] - Basmah N Aldosari, Ahmed A H Abdellatif, Alanood Sunhat Almurshedi, Iman Mohammed Alfagih, Bushra Tawfeeq AlQuadeib, Asmaa Youssef A Abbas, Yasser A Hassan, Ahmed Abdelfattah, Hesham M Tawfeek. Development of oral formulation of Lepidium seeds significantly decreases the high blood glucose levels in diabetic rats: in vitro formulation and in vivo antidiabetic performance.
Drug development and industrial pharmacy.
2024 Feb; 50(2):112-123. doi:
10.1080/03639045.2023.2300649. [PMID: 38156891] - Yanling Dai, Chen Qiu, Diandian Zhang, Mianli Li, Weinan Liu. Yam Gruel alone and in combination with metformin regulates hepatic lipid metabolism disorders in a diabetic rat model by activating the AMPK/ACC/CPT-1 pathway.
Lipids in health and disease.
2024 Jan; 23(1):28. doi:
10.1186/s12944-024-02014-2. [PMID: 38273354] - Ai Mi, Qinxue Hu, Ying Liu, Yanna Zhao, Fenglin Shen, Jinjian Lan, Keren Lv, Bolin Wang, Ruilan Gao, Xiaoling Yu. Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced NAFLD mice.
Food & function.
2024 Jan; 15(2):794-808. doi:
10.1039/d3fo03572g. [PMID: 38131276] - Raditya Dewangga, Kevin Winston, Lazuardi Gayu Ilhami, Suci Indriani, Taofan Siddiq, Suko Adiarto. Association of metformin use with abdominal aortic aneurysm: A systematic review and meta-analysis.
Asian cardiovascular & thoracic annals.
2024 Jan; ?(?):2184923231225794. doi:
10.1177/02184923231225794. [PMID: 38239055] - Paula Gallardo-Villanueva, Tamara Fernández-Marcelo, Laura Villamayor, Angela M Valverde, Sonia Ramos, Elisa Fernández-Millán, María Angeles Martín. Synergistic Effect of a Flavonoid-Rich Cocoa-Carob Blend and Metformin in Preserving Pancreatic Beta Cells in Zucker Diabetic Fatty Rats.
Nutrients.
2024 Jan; 16(2):. doi:
10.3390/nu16020273. [PMID: 38257166] - Dan Liang, Lu Liu, Yulin Qi, Feng Nan, Ju Huang, Shiyun Tang, Jianyuan Tang, Nianzhi Chen. Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II.
Journal of ethnopharmacology.
2024 Jan; 324(?):117745. doi:
10.1016/j.jep.2024.117745. [PMID: 38228231] - Roberto Citarrella, Roberta Chianetta, Simona Amodeo, Luigi Mirarchi, Anna Licata, Maurizio Soresi, Nicola Veronese, Mario Barbagallo, Lydia Giannitrapani. Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Cinnamomum zeylanicum Blume and Inulin in Patients with Metabolic Syndrome.
Nutrients.
2024 Jan; 16(2):. doi:
10.3390/nu16020249. [PMID: 38257142] - Yassmin Raafat Hassan, Riham A El-Shiekh, Hala M El Hefnawy, Osama G Mohamed, Karema Abu-Elfotuh, Ahmed M Hamdan, Alshaymaa Darwish, Ayah M H Gowifel, Ashootosh Tripathi, Camilia George Michael. A mechanistic exploration of the metabolome of African mango seeds and its potential to alleviate cognitive impairment induced by high-fat/high-carbohydrate diets: Involvement of PI3K/AKT/GSK-3β/CREB, PERK/CHOP/Bcl-2, and AMPK/SIRT-1/mTOR Axes.
Journal of ethnopharmacology.
2024 Jan; 324(?):117747. doi:
10.1016/j.jep.2024.117747. [PMID: 38218500] - Neda Rasouli, Naji Younes, Alokananda Ghosh, Jeanine Albu, Robert M Cohen, Ralph A DeFronzo, Elsa Diaz, Laure Sayyed Kassem, José A Luchsinger, Janet B McGill, William I Sivitz, William V Tamborlane, Kristina M Utzschneider, Steven E Kahn. Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Diabetes care.
2024 Jan; ?(?):. doi:
10.2337/dc23-1070. [PMID: 38211595] - M Sue Kirkman, Mark Tripputi, Heidi Krause-Steinrauf, Ionut Bebu, Hiba AbouAssi, Henry Burch, Elizabeth Duran-Valdez, Hermes Florez, W Timothy Garvey, Daniel S Hsia, Maamoun Salam, Rodica Pop-Busui. Comparative Effects of Randomized Second-line Therapy for Type 2 Diabetes on a Composite Outcome Incorporating Glycemic Control, Body Weight, and Hypoglycemia: An Analysis of Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Diabetes care.
2024 Jan; ?(?):. doi:
10.2337/dc23-1332. [PMID: 38194519] - Marco Pozzi, Chiara Vantaggiato, Francesca Brivio, Genny Orso, Maria Teresa Bassi. Olanzapine, risperidone and ziprasidone differently affect lysosomal function and autophagy, reflecting their different metabolic risk in patients.
Translational psychiatry.
2024 Jan; 14(1):13. doi:
10.1038/s41398-023-02686-x. [PMID: 38191558] - Salwa Bader, Rahila Bhatti, Bashair Mussa, Salah Abusanana. A systematic review of GLP-1 on anthropometrics, metabolic and endocrine parameters in patients with PCOS.
Women's health (London, England).
2024 Jan; 20(?):17455057241234530. doi:
10.1177/17455057241234530. [PMID: 38444070] - Tsugumasa Toma, Nobukazu Miyakawa, Mika Tateishi, Mikio Todaka, Tatsuya Kondo, Mikako Fujita, Masami Otsuka, Eiichi Araki, Hiroshi Tateishi. An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK.
Journal of pharmacological sciences.
2024 Jan; 154(1):37-46. doi:
10.1016/j.jphs.2023.11.005. [PMID: 38081682] - Xudong Zhuang, Zhuye Sun, Huasheng Du, Tianhui Zhou, Jing Zou, Wei Fu. Metformin inhibits high glucose-induced apoptosis of renal podocyte through regulating miR-34a/SIRT1 axis.
Immunity, inflammation and disease.
2024 Jan; 12(1):e1053. doi:
10.1002/iid3.1053. [PMID: 38270305] - Yong Lin, Huiling Zeng, Jieying Lin, Yiwei Peng, Xueyun Que, Lijun Wang, Ling Chen, Ni Bai. Evaluating the therapeutic potential of moxibustion on polycystic ovary syndrome: a rat model study on gut microbiota and metabolite interaction.
Frontiers in cellular and infection microbiology.
2024; 14(?):1328741. doi:
10.3389/fcimb.2024.1328741. [PMID: 38665877] - Nana Liu, Yanqiu Song, Ting Liu, Hongyu Wang, Naihao Yu, Hui Ma. Metformin enhanced the effect of pirfenidone on pulmonary fibrosis in mice.
The clinical respiratory journal.
2024 Jan; 18(1):e13731. doi:
10.1111/crj.13731. [PMID: 38286745] - Mahnaz Yavangi, Soghra Rabiee, Marzieh Sanavi Farimani, Shahede Khansary, Maryam Farhadian, Akram Ranjbar, Minoo Mahmoudi, Masoud Karimi, Somayeh Barati, Amir Barati Mosleh, Noushin Mohammadpour. The effects of green tea tablets and metformin on ovulation and menstrual cycle regularity in women with polycystic ovary syndrome.
Journal of medicine and life.
2024 Jan; 17(1):109-115. doi:
10.25122/jml-2022-0066. [PMID: 38737668] - Xiaojie Jiang, Tingting Shi, Dan Han, Juan Chen. Exenatide and Metformin Improve Serum Indices and Intestinal Flora in patients with Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease.
JPMA. The Journal of the Pakistan Medical Association.
2024 Jan; 74(1):138-140. doi:
10.47391/jpma.8295. [PMID: 38219182] - Laya Hooshmand Gharabagh, Ali Shargh, Mohammad Reza Mohammad Hosseini Azar, Ayda Esmaeili. Comparison between the effect of Empagliflozin and Pioglitazone added to metformin in patients with type 2 diabetes and nonalcoholic fatty liver disease.
Clinics and research in hepatology and gastroenterology.
2023 Dec; 48(3):102279. doi:
10.1016/j.clinre.2023.102279. [PMID: 38159676] - Man Ki Kwok, C Mary Schooling. Unraveling Potential Sex-Specific Effects of Cardiovascular Medications on Longevity Using Mendelian Randomization.
Journal of the American Heart Association.
2023 Dec; 12(24):e030943. doi:
10.1161/jaha.123.030943. [PMID: 38108247] - Yang Shu, Weidong Li, Qiongying Hu, Daqian Xiong. Bibliometrics and visual analysis of metformin and gut microbiota from 2012 to 2022: A systematic review.
Medicine.
2023 Dec; 102(50):e36478. doi:
10.1097/md.0000000000036478. [PMID: 38115325] - Joseph Boachie, Victor Zammit, Ponnusamy Saravanan, Antonysunil Adaikalakoteswari. Metformin Inefficiency to Lower Lipids in Vitamin B12 Deficient HepG2 Cells Is Alleviated via Adiponectin-AMPK Axis.
Nutrients.
2023 Dec; 15(24):. doi:
10.3390/nu15245046. [PMID: 38140305] - Yuanyuan Cao, Mingyi Wo, Chan Xu, Xianming Fei, Juan Jin, Zhiming Shan. An AMPK agonist suppresses the progress of colorectal cancer by regulating the polarization of TAM to M1 through inhibition of HIF-1α and mTOR signal pathway.
Journal of cancer research and therapeutics.
2023 Dec; 19(6):1560-1567. doi:
10.4103/jcrt.jcrt_2670_22. [PMID: 38156922] - Lili Cheng, R N V Krishna Deepak, Guoqiang Wang, Ziyi Meng, Lei Tao, Mengqing Xie, Wenna Chi, Yuming Zhang, Mingming Yang, Yilie Liao, Ruiqun Chen, Yu Liang, Junyu Zhang, Yuedong Huang, Weihua Wang, Zhiying Guo, Yunfang Wang, Jiandie D Lin, Hao Fan, Ligong Chen. Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis.
Hepatology (Baltimore, Md.).
2023 Dec; 78(6):1828-1842. doi:
10.1097/hep.0000000000000314. [PMID: 36804859] - Yue Sun, Ya-Ping Bai, De-Guo Wang, Yu-Jie Xing, Teng Zhang, Wen Wang, Si-Min Zhou, Jin-Han Cheng, Wei-Wei Chang, Xiang Kong, Xin-Ming Yao, Li-Qun Guo. Protective effects of metformin on pancreatic β-cell ferroptosis in type 2 diabetes in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 168(?):115835. doi:
10.1016/j.biopha.2023.115835. [PMID: 37924788] - Hao Wang, Yanping Wang, Hongmin Zhang, Zerong Liang, Wenjing Hu, Sheng Qiu, Ke Li, Lili Zhang, Han Dai, Mengliu Yang, Gangyi Yang, Ling Li. Hedgehog interacting protein as a circulating biomarker in women with obesity: a cross-sectional study and intervention studies.
Annals of medicine.
2023 12; 55(1):2206162. doi:
10.1080/07853890.2023.2206162. [PMID: 37166403] - Batool Zamani, Seyyed Mashaalah Tabatabizadeh, Hamidreza Gilasi, Shadi Yazdani. Effects of pioglitazone and linagliptin on glycemic control, lipid profile and hs-CRP in metformin-treated patients with type 2 diabetes: a comparative study.
Hormone molecular biology and clinical investigation.
2023 Dec; 44(4):385-391. doi:
10.1515/hmbci-2022-0070. [PMID: 38143260] - Hanem M Rabah, Darin A Mohamed, Reham A Mariah, Sarah R Abd El-Khalik, Haidy A Khattab, Norhan A AbuoHashish, Amal M Abdelsattar, Mohamed A Raslan, Eman E Farghal, Amira K Eltokhy. Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue.
Redox report : communications in free radical research.
2023 Dec; 28(1):2160569. doi:
10.1080/13510002.2022.2160569. [PMID: 36661246] - Hesham Shamshoum, Kyle D Medak, Greg L McKie, Stewart Jeromson, Margaret K Hahn, David C Wright. Salsalate and/or metformin therapy confer beneficial metabolic effects in olanzapine treated female mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 168(?):115671. doi:
10.1016/j.biopha.2023.115671. [PMID: 37839107] - Babu Lal Kumawat, Pramod Kumar, Ajit Singh Mahla, Ashok Kumar, Amit Kumar, Raghvendar Singh, Arun Kumar. A novel action of insulin sensitizing drug as a potential promotor of preovulatory follicles, ovulation rate and prolificacy in sheep.
Veterinary research communications.
2023 Nov; ?(?):. doi:
10.1007/s11259-023-10259-y. [PMID: 37957451] - Johanna M Melin, Maria Forslund, Simon J Alesi, Terhi Piltonen, Daniela Romualdi, Poli M Spritzer, Chau Thien Tay, Alexia S Pena, Selma F Witchel, Aya Mousa, Helena J Teede. Effects of different insulin sensitisers in the management of polycystic ovary syndrome: A systematic review and meta-analysis.
Clinical endocrinology.
2023 Nov; ?(?):. doi:
10.1111/cen.14983. [PMID: 37933831] - Simon Paquette, Sean C Thomas, Krishnan Venkataraman, Vasu D Appanna, Sujeenthar Tharmalingam. The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review.
Nutrients.
2023 Nov; 15(21):. doi:
10.3390/nu15214690. [PMID: 37960343] - Adriana Bajetto, Alessandra Pattarozzi, Rodolfo Sirito, Federica Barbieri, Tullio Florio. Metformin potentiates immunosuppressant activity and adipogenic differentiation of human umbilical cord-mesenchymal stem cells.
International immunopharmacology.
2023 Nov; 124(Pt B):111078. doi:
10.1016/j.intimp.2023.111078. [PMID: 37844465] - Zhe Tang, Jing Guan, Jue-Hui Mao, Lu Han, Juan-Juan Zhang, Rui Chen, Zheng Jiao. Quantitative risk-benefit profiles of oral contraceptives, insulin sensitizers and antiandrogens for women with polycystic ovary syndrome: A model-based meta-analysis.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2023 Nov; 190(?):106577. doi:
10.1016/j.ejps.2023.106577. [PMID: 37666459] - Manal Moustafa Mahmoud, Laila Ahmed Rashed, Somia Abdulatif Soliman, Safaa Mostafa Sayed, Omneya Kamel, Samaa Samir Kamar, Rania El Sayed Hussien. SGLT-2 inhibitors enhance the effect of metformin to ameliorate hormonal changes and inflammatory markers in a rat PCOS model.
Physiological reports.
2023 Nov; 11(22):e15858. doi:
10.14814/phy2.15858. [PMID: 37985173] - Reina Owaki, Hiromasa Aoki, Kohki Toriuchi, Yasumichi Inoue, Hidetoshi Hayashi, Satoru Takeshita, Hiroki Kakita, Yasumasa Yamada, Mineyoshi Aoyama. AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway.
Experimental cell research.
2023 Nov; 432(1):113784. doi:
10.1016/j.yexcr.2023.113784. [PMID: 37730144] - Swapnali Vasant Birajdar, Farhan Mazahir, Md Imtiyaz Alam, Amit Kumar, Awesh K Yadav. Repurposing and clinical attributes of antidiabetic drugs for the treatment of neurodegenerative disorders.
European journal of pharmacology.
2023 Oct; ?(?):176117. doi:
10.1016/j.ejphar.2023.176117. [PMID: 37907134] - Yong-Kang Wei, Ping-Bo Chen, Ling-Ling Ju, Guang-Hua Deng. Causal association of metformin and osteoporosis: A 2-sample Mendelian randomization study.
Medicine.
2023 Oct; 102(43):e35191. doi:
10.1097/md.0000000000035191. [PMID: 37904346] - Hanan S Anbar, Nisha Yarifbhai Vahora, Hajra Laghman Shah, Mariyam Mohammed Azam, Tamanna Islam, Fatima Hersi, Hany A Omar, Wolfgang Dohle, Barry V L Potter, Mohammed I El-Gamal. Promising drug candidates for the treatment of polycystic ovary syndrome (PCOS) as alternatives to the classical medication metformin.
European journal of pharmacology.
2023 Oct; ?(?):176119. doi:
10.1016/j.ejphar.2023.176119. [PMID: 37852569] - Song-Li Hao, Chun-Lan Zhang, Xiao-Yu Meng. Comparison of different drug for reducing testosterone levels in women with polycystic ovary syndrome: A systematic review and network meta-analysis.
Medicine.
2023 Oct; 102(41):e35152. doi:
10.1097/md.0000000000035152. [PMID: 37832133] - B O Ajiboye, S Dada, H O Fatoba, O E Lawal, O H Oyeniran, O Y Adetuyi, A Olatunde, M Taher, J Khotib, D Susanti, B E Oyinloye. Dalbergiella welwitschia (Baker) Baker f. alkaloid-rich extracts attenuate liver damage in streptozotocin-induced diabetic rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Oct; 168(?):115681. doi:
10.1016/j.biopha.2023.115681. [PMID: 37837880] - Xue Yang, Zhiwei He, Li Yuan, Wenbin Huang, Doudou Li, Pingping Xiang, Yu Chen, Guofang Chen, Chao Liu. Remission effect of Canagliflozin in patients with newly diagnosed type 2 diabetes mellitus: a protocol for a multicenter, parallel-group, randomized, controlled, open-label trial.
BMC endocrine disorders.
2023 Oct; 23(1):215. doi:
10.1186/s12902-023-01461-9. [PMID: 37814256] - F de Zegher, M Díaz, L Ibáñez. Adolescent polycystic ovary syndrome without obesity: HOTAIR rs1443512 genotype relates to fat mass and to the redistribution of fat mass on low-dose pioglitazone.
Journal of endocrinological investigation.
2023 Oct; ?(?):. doi:
10.1007/s40618-023-02206-0. [PMID: 37805962] - Ying Li, Qingqian Zhang, Jintao Yang, Weiping He, Yulan Jiang, Yu Chen, Yifan Wang. Metformin combined with glucose starvation synergistically suppress triple-negative breast cancer by enhanced unfolded protein response.
Biochemical and biophysical research communications.
2023 10; 675(?):146-154. doi:
10.1016/j.bbrc.2023.07.029. [PMID: 37473529] - Xingjian Zhang, Xin Hu, Yijun Xie, Lejing Xie, Xiangyi Chen, Mei Peng, Duo Li, Jun Deng, Di Xiao, Xiaoping Yang. Metformin-Loaded Chitosan Hydrogels Suppress Bladder Tumor Growth in an Orthotopic Mouse Model via Intravesical Administration.
Molecules (Basel, Switzerland).
2023 Sep; 28(18):. doi:
10.3390/molecules28186720. [PMID: 37764495] - Sneha Soni, Pooja Yadav, Chandi C Mandal. Metformin ameliorates BMP2 induced adipocyte-like property in breast cancer cells.
Biochemical and biophysical research communications.
2023 09; 672(?):201-208. doi:
10.1016/j.bbrc.2023.06.044. [PMID: 37406485] - Xianmei Liu, Peng Yu, Yujun Xu, Yun Wang, Jin Chen, Fuzhou Tang, Zuquan Hu, Jing Zhou, Lina Liu, Wei Qiu, Yuannong Ye, Yi Jia, Weijuan Yao, Jinhua Long, Zhu Zeng. Metformin induces tolerogenicity of dendritic cells by promoting metabolic reprogramming.
Cellular and molecular life sciences : CMLS.
2023 Sep; 80(10):283. doi:
10.1007/s00018-023-04932-3. [PMID: 37688662] - Kinga Ilona Nyulas, Mariana Cornelia Tilinca, Sándor Pál, Erzsébet Májai Fogarasi, Mircea Dumitru Croitoru, Robert Gabriel Tripon, Zoltán Preg, Márta Germán-Salló, Zsuzsánna Simon-Szabó, Enikő Nemes-Nagy. Assessment of vitamin B12 levels and cardiovascular risk factors in metformin- and non-metformin-treated type 2 diabetic patients.
Pakistan journal of pharmaceutical sciences.
2023 Sep; 36(5):1399-1405. doi:
". [PMID: 37869915] - Hanaa S S Gazwi, Mohamed Sh Hassan, Hamadi A Ismail, Gamal F Abd El-Naem, Sallam K Tony. The Hypoglycemic and Hypolipidemic Effects of Polyphenol-Rich Strawberry Juice on Diabetic Rats.
Plant foods for human nutrition (Dordrecht, Netherlands).
2023 Sep; 78(3):512-519. doi:
10.1007/s11130-023-01079-1. [PMID: 37462847] - Dongya Chen, Jingfang Xiong, Gaofeng Chen, Zhaolin Zhang, Yihui Liu, Jianjun Xu, Hong Xu. Comparing the Influences of Metformin and Berberine on the Intestinal Microbiota of Rats With Nonalcoholic Steatohepatitis.
In vivo (Athens, Greece).
2023 Sep; 37(5):2105-2127. doi:
10.21873/invivo.13308. [PMID: 37652508] - Nikolaos Gkiourtzis, Panagiota Michou, Maria Moutafi, Agni Glava, Konstantinos Cheirakis, Aristeidis Christakopoulos, Eleni Vouksinou, Maria Fotoulaki. The benefit of metformin in the treatment of pediatric non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials.
European journal of pediatrics.
2023 Aug; ?(?):. doi:
10.1007/s00431-023-05169-9. [PMID: 37639015] - Lucydalila Cedillo, Fasih M Ahsan, Sainan Li, Nicole L Stuhr, Yifei Zhou, Yuyao Zhang, Adebanjo Adedoja, Luke M Murphy, Armen Yerevanian, Sinclair Emans, Khoi Dao, Zhaozhi Li, Nicholas D Peterson, Jeramie Watrous, Mohit Jain, Sudeshna Das, Read Pukkila-Worley, Sean P Curran, Alexander A Soukas. Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans.
eLife.
2023 08; 12(?):. doi:
10.7554/elife.82210. [PMID: 37606250] - Zhigang Wang, Erxing Tao, Yiming Chen, Qi Wang, Min Liu, Liang Wei, Siyi Xu, Wei Chen, Chunlong Zhong. NDUFA4 promotes the progression of head and neck paraganglioma by inhibiting ferroptosis.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
2023 Aug; ?(?):. doi:
10.1139/bcb-2023-0018. [PMID: 37602474] - Jianheng Ye, Shanghua Cai, Yuanfa Feng, Jinchuang Li, Zhiduan Cai, Yulin Deng, Ren Liu, Xuejin Zhu, Jianming Lu, Yangjia Zhuo, Yingke Liang, Jianjiang Xie, Yanqiong Zhang, Huichan He, Zhaodong Han, Zhenyu Jia, Weide Zhong. Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer.
Signal transduction and targeted therapy.
2023 08; 8(1):303. doi:
10.1038/s41392-023-01516-2. [PMID: 37582751] - Victoria O Oyanna, Kenisha Y Garcia-Torres, Baron J Bechtold, Katherine D Lynch, M Ridge Call, Miklós Horváth, Preston K Manwill, Tyler N Graf, Nadja B Cech, Nicholas H Oberlies, Mary F Paine, John D Clarke. Goldenseal-mediated inhibition of intestinal uptake transporters decreases metformin systemic exposure in mice.
Drug metabolism and disposition: the biological fate of chemicals.
2023 Aug; ?(?):. doi:
10.1124/dmd.123.001360. [PMID: 37562957] - Yifei Geng, Zhen Wang, Xiaoyu Xu, Xiao Sun, Xi Dong, Yun Luo, Xiaobo Sun. Extensive therapeutic effects, underlying molecular mechanisms and disease treatment prediction of Metformin: a systematic review.
Translational research : the journal of laboratory and clinical medicine.
2023 Aug; ?(?):. doi:
10.1016/j.trsl.2023.08.001. [PMID: 37567440] - Amirhossein Malaekeh-Nikouei, Sina Shokri-Naei, Sobhan Karbasforoushan, Hossein Bahari, Vafa Baradaran Rahimi, Reza Heidari, Vahid Reza Askari. Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Aug; 165(?):115263. doi:
10.1016/j.biopha.2023.115263. [PMID: 37541178] - Kunal Sarkar, Sarbashri Bank, Arindam Chatterjee, Koushik Dutta, Anwesha Das, Santanu Chakraborty, Nirvika Paul, Jit Sarkar, Sriparna De, Sudakshina Ghosh, Krishnendu Acharyya, Dipankar Chattopadhyay, Madhusudan Das. Hyaluronic acid-graphene oxide quantum dots nanoconjugate as dual purpose drug delivery and therapeutic agent in meta-inflammation.
Journal of nanobiotechnology.
2023 Aug; 21(1):246. doi:
10.1186/s12951-023-02015-w. [PMID: 37528408] - Benjamin Wancewicz, Yanlong Zhu, Rachel J Fenske, Alicia M Weeks, Kent Wenger, Samantha Pabich, Michael Daniels, Margaret Punt, Randall Nall, Darby C Peter, Allan Brasier, Elizabeth D Cox, Dawn Belt Davis, Ying Ge, Michelle E Kimple. Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort.
The Journal of pharmacology and experimental therapeutics.
2023 08; 386(2):169-180. doi:
10.1124/jpet.122.001493. [PMID: 36918276] - Shuihong Zheng, Huaying Huang, Heye Chen, Yanfen Liu. Glp-1 Receptor Agonists Regulate the Progression of Diabetes Mellitus Complicated with Fatty Liver by Down-regulating the Expression of Genes Related to Lipid Metabolism.
Applied biochemistry and biotechnology.
2023 Aug; 195(8):5238-5251. doi:
10.1007/s12010-023-04505-x. [PMID: 37140780] - Sheba R David, Penny Pei Ni Lai, Jestin Chellian, Srikumar Chakravarthi, Rajan Rajabalaya. Influence of rutin and its combination with metformin on vascular functions in type 1 diabetes.
Scientific reports.
2023 08; 13(1):12423. doi:
10.1038/s41598-023-39442-6. [PMID: 37528147] - Junqi Men, Li Zhang, Ruiyun Peng, Yanyang Li, Meng Li, Hui Wang, Li Zhao, Jing Zhang, Haoyu Wang, Xinping Xu, Ji Dong, Juan Wang, Binwei Yao, Jiabin Guo. Metformin Ameliorates 2.856 GHz Microwave- Radiation-Induced Reproductive Impairments in Male Rats via Inhibition of Oxidative Stress and Apoptosis.
International journal of molecular sciences.
2023 Jul; 24(15):. doi:
10.3390/ijms241512250. [PMID: 37569626] - Ting Xiong, Eloise Fraison, Eleni Kolibianaki, Michael F Costello, Christos Venetis, Elena B Kostova. Statins for women with polycystic ovary syndrome not actively trying to conceive.
The Cochrane database of systematic reviews.
2023 07; 7(?):CD008565. doi:
10.1002/14651858.cd008565.pub3. [PMID: 37462232] - José Carlos Tapia-Rivera, Héctor Eduardo Mendoza-Jaramillo, Christian Octavio González-Villaseñor, Mario Ramirez-Flores, José Alonso Aguilar-Velazquez, Andres López-Quintero, Edsaúl Emilio Pérez-Guerrero, María de Los Ángeles Vargas-Rodriguez, Itzae Adonai Gutiérrez-Hurtado, Erika Martínez-López. Effect of Human Adenovirus 36 on Response to Metformin Monotherapy in Obese Mexican Patients with Type 2 Diabetes: A Prospective Cohort Study.
Viruses.
2023 07; 15(7):. doi:
10.3390/v15071514. [PMID: 37515200] - Dongjun Li, Ang Zhao, Jiafei Zhu, Chunjie Wang, Jingjing Shen, Zixuan Zheng, Feng Pan, Zhuang Liu, Qian Chen, Yang Yang. Inhaled Lipid Nanoparticles Alleviate Established Pulmonary Fibrosis.
Small (Weinheim an der Bergstrasse, Germany).
2023 07; 19(30):e2300545. doi:
10.1002/smll.202300545. [PMID: 37058092] - Salma F Hassan, Asser I Ghoneim, Doaa A Ghareeb, Hisham A Nematalla. Portulaca oleracea L. (purslane) improves the anti-inflammatory, antioxidant and autophagic actions of metformin in the hippocampus of diabetic demented rats.
Fitoterapia.
2023 Jul; 168(?):105566. doi:
10.1016/j.fitote.2023.105566. [PMID: 37295752] - Eda Dagsuyu, Pınar Koroglu, Ilknur B Gul, Omur K Bulan, Refiye Yanardag. Oxidative brain and cerebellum injury in diabetes and prostate cancer model: Protective effect of metformin.
Journal of biochemical and molecular toxicology.
2023 Jun; ?(?):e23440. doi:
10.1002/jbt.23440. [PMID: 37354076] - Leonardo de Andrade Mesquita, Laura Fink Wayerbacher, Gilberto Schwartsmann, Fernando Gerchman. Obesity, diabetes, and cancer: epidemiology, pathophysiology, and potential interventions.
Archives of endocrinology and metabolism.
2023 Jun; 67(6):e000647. doi:
10.20945/2359-3997000000647. [PMID: 37364149] - Zongqiang Hu, Yingpeng Zhao, Laibang Li, Jie Jiang, Wang Li, Yuanyi Mang, Yang Gao, Yun Dong, Jiashun Zhu, Chaomin Yang, Jianghua Ran, Li Li, Shengning Zhang. Metformin promotes ferroptosis and sensitivity to sorafenib in hepatocellular carcinoma cells via ATF4/STAT3.
Molecular biology reports.
2023 Jun; ?(?):. doi:
10.1007/s11033-023-08492-4. [PMID: 37326750] - Sadra Samavarchi Tehrani, Golnaz Goodarzi, Ghodratollah Panahi, Fahimeh Zamani-Garmsiri, Reza Meshkani. The combination of metformin with morin alleviates hepatic steatosis via modulating hepatic lipid metabolism, hepatic inflammation, brown adipose tissue thermogenesis, and white adipose tissue browning in high-fat diet-fed mice.
Life sciences.
2023 Jun; 323(?):121706. doi:
10.1016/j.lfs.2023.121706. [PMID: 37075944] - Kuniyuki Nishiyama, Masato Ono, Takahiro Tsuno, Ryota Inoue, Ayako Fukunaka, Tomoko Okuyama, Mayu Kyohara, Yu Togashi, Setsuko Fukushima, Takuto Atsumi, Aoi Sato, Asuka Tsurumoto, Chisato Sakai, Yoshio Fujitani, Yasuo Terauchi, Shuichi Ito, Jun Shirakawa. Protective effects of imeglimin and metformin combination therapy on β-cells in db/db male mice.
Endocrinology.
2023 Jun; ?(?):. doi:
10.1210/endocr/bqad095. [PMID: 37314160]
