Colchicine (BioDeep_00000000135)

 

Secondary id: BioDeep_00000398558

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs Antitumor activity Cytotoxicity


代谢物信息卡片


N-{3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0²,⁷]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl}acetamide

化学式: C22H25NO6 (399.1682)
中文名称: 秋水仙碱, 秋水仙素
谱图信息: 最多检出来源 Viridiplantae(plant) 23.47%

Reviewed

Last reviewed on 2024-10-11.

Cite this Page

Colchicine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/colchicine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000135). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C/C(=N\[C@H]1CCc2cc(c(c(c2-c3c1cc(=O)c(cc3)OC)OC)OC)OC)/O
InChI: InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)

描述信息

Colchicine appears as odorless or nearly odorless pale yellow needles or powder that darkens on exposure to light. Used to treat gouty arthritis, pseudogout, sarcoidal arthritis and calcific tendinitis. (EPA, 1998)
(S)-colchicine is a colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions. It has a role as a mutagen, an anti-inflammatory agent and a gout suppressant. It is a colchicine and an alkaloid. It is an enantiomer of a (R)-colchicine.
Colchicine is an Alkaloid.
Colchicine is a plant alkaloid that is widely used for treatment of gout. Colchicine has not been associated with acute liver injury or liver test abnormalities except with serious overdoses.
Colchicine is a natural product found in Colchicum arenarium, Colchicum bivonae, and other organisms with data available.
Colchicine is an alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflammatory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals.
A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).
See also: Colchicine; probenecid (component of).
Colchicine is only found in individuals that have used or taken this drug. It is a major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (periodic disease). [PubChem]The precise mechanism of action has not been completely established. In patients with gout, colchicine apparently interrupts the cycle of monosodium urate crystal deposition in joint tissues and the resultant inflammatory response that initiates and sustains an acute attack. Colchicine decreases leukocyte chemotaxis and phagocytosis and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals. Colchicine also inhibits urate crystal deposition, which is enhanced by a low pH in the tissues, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Colchicine has no analgesic or antihyperuricemic activity. Colchicine inhibits microtubule assembly in various cells, including leukocytes, probably by binding to and interfering with polymerization of the microtubule subunit tubulin. Although some studies have found that this action probably does not contribute significantly to colchicines antigout action, a recent in vitro study has shown that it may be at least partially involved.
CONFIDENCE standard compound; INTERNAL_ID 328; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7704; ORIGINAL_PRECURSOR_SCAN_NO 7702
CONFIDENCE standard compound; INTERNAL_ID 328; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7690; ORIGINAL_PRECURSOR_SCAN_NO 7687
CONFIDENCE standard compound; INTERNAL_ID 328; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7668; ORIGINAL_PRECURSOR_SCAN_NO 7666
CONFIDENCE standard compound; INTERNAL_ID 328; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7693; ORIGINAL_PRECURSOR_SCAN_NO 7689
CONFIDENCE standard compound; INTERNAL_ID 328; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7645; ORIGINAL_PRECURSOR_SCAN_NO 7643
CONFIDENCE standard compound; INTERNAL_ID 328; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7687; ORIGINAL_PRECURSOR_SCAN_NO 7684
M - Musculo-skeletal system > M04 - Antigout preparations > M04A - Antigout preparations > M04AC - Preparations with no effect on uric acid metabolism
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials, Guide to PHARMACOLOGY
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
D018501 - Antirheumatic Agents > D006074 - Gout Suppressants
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2258
INTERNAL_ID 2258; CONFIDENCE Reference Standard (Level 1)
[Raw Data] CB194_Colchicine_pos_30eV_CB000068.txt
[Raw Data] CB194_Colchicine_pos_50eV_CB000068.txt
[Raw Data] CB194_Colchicine_pos_10eV_CB000068.txt
[Raw Data] CB194_Colchicine_pos_20eV_CB000068.txt
[Raw Data] CB194_Colchicine_pos_40eV_CB000068.txt
CONFIDENCE standard compound; INTERNAL_ID 1171
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].
Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

同义名列表

151 个代谢物同义名

N-{3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0²,⁷]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl}acetamide; (1e)-N-[(7s)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl] ethanimidic acid; N-[(7S,12aP)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide; Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-; Acetamide, N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-; Acetamide, N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-; ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)-,(S)-; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-acetamide; N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- acetamide; N-((7S)-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo(a)heptalen-7-yl))acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide; N-((7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo(a)heptalen-7-yl)acetamide; N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(ALPHA)HEPTALEN-7-YL)-ACETAMIDE; N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; N-((7S)-5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZ(A)HEPTALEN-7-YL)-ACETAMIDE; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; (S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)ACETAMIDE; N-[(7s)-1,2,3,10-Tetramethoxy-9-Oxo-6,7-Dihydro-5h-Benzo[d]heptalen-7-Yl]ethanamide; Acetamide,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(.alpha.)heptalen-7-yl)-; Acetamide,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]acetamide; ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL); N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide; Colchicine for system suitability, European Pharmacopoeia (EP) Reference Standard; N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO(A)HEPTALEN-7-YL)-ACETAMIDE; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide; Colchicine, Pharmaceutical Secondary Standard; Certified Reference Material; Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-; 7-Acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-benzo(a)heptalen-9(5H)-one; 7-ACETAMIDO-6,7-DIHYDRO-1,2,3,10-TETRAMETHOXYBENZO(A)HEPTALEN-9(5H)-ONE; Colchicine, BioReagent, plant cell culture tested, >=95\\% (HPLC); Colchicine, United States Pharmacopeia (USP) Reference Standard; Colchicine, (European Pharmacopoeia (EP) Reference Standard); N-((7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo; Benzo[a]heptalen-9(5H)-one,7-dihydro-1,2,3,10-tetramethoxy-; Colchicine (contains 5\\% Ethyl Acetate at maximum); N-ACETYL TRIMETHYLCOLCHICINIC ACID, METHYL ETHER; binds to tubulin; inhibits microtubular assembly; N-ACETYLTRIMETHYLCOLCHICINIC ACID METHYL ETHER; N-Acetyl trimethylcolchicinic acid methylether; Colchicine; Thiocolchicoside Impurity A; COLCHICINE COMPONENT OF COL-PROBENECID; COL-PROBENECID COMPONENT COLCHICINE; COLCHICINE IMPURITY B [EP IMPURITY]; BENZO(A)HEPTALENE, ACETAMIDE DERIV.; COLCHICINE COMPONENT OF COLBENEMID; Colchicine, >=95\\% (HPLC), powder; Colchicine conformational isomer; COLCHICINE COMPONENT OF MITIGARE; COLCHICINE COMPONENT OF PROBEN-C; COLBENEMID COMPONENT COLCHICINE; PROBEN-C COMPONENT COLCHICINE; MITIGARE COMPONENT COLCHICINE; Colchicine, >=96.0\\% (HPLC); COLCHICINE [USP MONOGRAPH]; COLCHICINE (USP MONOGRAPH); COLCHICINUM [WHO-IP LATIN]; COLCHICINE [EP MONOGRAPH]; COLCHICINE (EP MONOGRAPH); Colchicine Tablets 0.5 mg; COLCHICINE [EP IMPURITY]; COLCHICEINE METHYL ETHER; COLCHICINE [ORANGE BOOK]; COLCHICINE (EP IMPURITY); Colchicine, (+-)-Isomer; Colchicine, (R)-Isomer; Colchicine (JP17/USP); 7.alpha.H-Colchicine; 7-alpha-H-Colchicine; Colchicine [USP:JAN]; Colchicine (USP:JAN); (S)-Colchicine >95\\%; Colchicina [Italian]; COLCHICINE [WHO-DD]; COLCHICINE [WHO-IP]; COLCHICINE (USP-RS); COLCHICINE [USP-RS]; 7alpha-H-Colchicine; COLCHICINUM [HPUS]; 7alphaH-Colchicine; Colchicin [German]; COLCHICINE [MART.]; COLCHICINE (MART.); Prestwick2_000363; COLCHICINE [HSDB]; Prestwick1_000363; Prestwick3_000363; COLCHCINE [VANDF]; Prestwick0_000363; Spectrum5_000787; Spectrum2_000075; Spectrum4_000298; Colchicine [JAN]; Spectrum3_000362; COLCHICINE [MI]; UNII-SML2Y3J35T; Colchicine (TN); (S)-colchicine; (S)-colchicina; (-)-colchicine; Tox21_110947_1; spindle poison; COLCHICINUM 4x; BPBio1_000535; DivK1c_000753; Lopac0_000310; (S)-colchicin; MEGxp0_001879; KBio2_001322; KBio1_000753; KBio2_006458; KBio3_001303; Tox21_110947; ACon1_000353; KBio2_003890; Tox21_300582; Tox21_500310; Tox21_201547; NCI60_041659; IDI1_000753; Colchicinum; COLCHICENOS; CAS-64-86-8; 7JX9WZ3SJ5; SML2Y3J35T; Colchicina; Colchineos; Colchicine; Colchisol; Colsaloid; Colchysat; AI3-31149; Colchcine; Colchicin; COLCIGEL; Mitigare; Colchine; Condylon; GLOPERBA; Kolkicin; Goutnil; Colstat; Colcrys; LODOCO; Colcin; (-)-N-; XD25; 4o2b; 4lzr; LOC; Colchicine



数据库引用编号

56 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

42 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, AXIN2, BDNF, CA1, CA3, CYP3A4, GAL, IL1A, XDH
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 1 CYP3A4
Nucleus 4 ACHE, ALB, AXIN2, IL1A
cytosol 9 ALB, AXIN2, CA1, CA3, IL1A, IL1RN, NGF, PRKCQ, XDH
dendrite 2 BDNF, NGF
trans-Golgi network 1 CA4
centrosome 3 ALB, AXIN2, IL1RN
nucleoplasm 2 ATP2B1, IL1RN
Cell membrane 6 ACHE, ATP2B1, CA4, CD79A, GAL, TNF
Multi-pass membrane protein 1 ATP2B1
Synapse 3 ACHE, ATP2B1, CRH
cell surface 4 ACHE, CA4, IL1A, TNF
glutamatergic synapse 1 ATP2B1
Golgi apparatus 3 ACHE, ALB, CA4
neuromuscular junction 1 ACHE
neuronal cell body 2 GAL, TNF
presynaptic membrane 1 ATP2B1
synaptic vesicle 2 BDNF, NGF
plasma membrane 10 ACHE, ATP2B1, AXIN2, CA4, CD79A, GAL, IFNLR1, IL1RN, PRKCQ, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 6 ACHE, ATP2B1, BDNF, CA4, CYP3A4, IFNLR1
apical plasma membrane 1 CA4
axon 2 BDNF, NGF
basolateral plasma membrane 1 ATP2B1
extracellular exosome 6 ALB, ATP2B1, CA1, CA4, IL1RN, LYZ
endoplasmic reticulum 1 ALB
extracellular space 11 ACHE, ALB, BDNF, CRH, GAL, IL1A, IL1RN, LYZ, NGF, TNF, XDH
perinuclear region of cytoplasm 3 ACHE, BDNF, CA4
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 2 ATP2B1, CYP3A4
Microsome membrane 1 CYP3A4
Single-pass type I membrane protein 2 CD79A, IFNLR1
Secreted 7 ACHE, ALB, BDNF, CRH, GAL, IL1A, NGF
extracellular region 9 ACHE, ALB, BDNF, CRH, GAL, IL1A, LYZ, NGF, TNF
Extracellular side 1 ACHE
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 3 CA4, CD79A, TNF
varicosity 1 CRH
multivesicular body 1 CD79A
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
beta-catenin destruction complex 1 AXIN2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 CD79A, TNF
Peroxisome 1 XDH
basement membrane 1 ACHE
sarcoplasmic reticulum 1 XDH
secretory granule 1 GAL
lateral plasma membrane 1 ATP2B1
ciliary basal body 1 ALB
cell projection 1 ATP2B1
phagocytic cup 1 TNF
centriole 1 ALB
brush border membrane 1 CA4
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 2 ACHE, CA4
endosome lumen 1 NGF
Presynaptic cell membrane 1 ATP2B1
side of membrane 2 ACHE, CA4
secretory granule membrane 1 CA4
Golgi lumen 1 NGF
endoplasmic reticulum lumen 2 ALB, BDNF
platelet alpha granule lumen 1 ALB
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
azurophil granule lumen 1 LYZ
immunological synapse 2 ATP2B1, PRKCQ
aggresome 1 PRKCQ
endoplasmic reticulum-Golgi intermediate compartment 1 CA4
synaptic cleft 1 ACHE
Rough endoplasmic reticulum 1 CA4
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IL1RN
IgM B cell receptor complex 1 CD79A
transport vesicle membrane 1 CA4
photoreceptor ribbon synapse 1 ATP2B1
B cell receptor complex 1 CD79A
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • M Khairuzzaman, Md Mehedi Hasan, Mohammad Tuhin Ali, Abdullah Al Mamun, Sheuly Akter, Papia Nasrin, Md Khirul Islam, Akhlak Un Nahar, Dipto Kumer Sarker, Omer Abdalla Ahmed Hamdi, Shaikh Jamal Uddin, Veronique Seidel, Jamil A Shilpi. Anthelmintic screening of Bangladeshi medicinal plants and related phytochemicals using in vitro and in silico methods: An ethnobotanical perspective. Journal of ethnopharmacology. 2024 Jun; 328(?):118132. doi: 10.1016/j.jep.2024.118132. [PMID: 38565411]
  • Xin Zhang, Ziyu Zheng, Jing Wang, Yuwen Li, Yan Gao, Lixia Li, Yujuan Pang, Fuhua Bian. In vitro induction of tetraploids and their phenotypic and transcriptome analysis in Glehnia littoralis. BMC plant biology. 2024 May; 24(1):439. doi: 10.1186/s12870-024-05154-w. [PMID: 38778255]
  • Muhammad Wasim Haider, Muhammad Nafees, Rashid Iqbal, Habat Ullah Asad, Farrukh Azeem, Muhammad Samsam Raza, Abdel-Rhman Z Gaafar, Mohamed S Elshikh, Muhammad Arslan, Muhammad Habib Ur Rahman, Ayman M S Elshamly. Exploring the mechanism of transformation in Acacia nilotica (Linn.) triggered by colchicine seed treatment. BMC plant biology. 2024 May; 24(1):428. doi: 10.1186/s12870-024-05139-9. [PMID: 38773358]
  • Artemio García-Escobar, Rosa Lázaro-García, José-Ángel Cabrera, Alfonso Jurado-Román, Raúl Moreno. High systemic inflammation as a novel cardiovascular risk factor and target for anti-cytokine therapy: comment regarding the triglyceride glucose index. The international journal of cardiovascular imaging. 2024 Apr; 40(4):945-948. doi: 10.1007/s10554-024-03046-6. [PMID: 38558330]
  • Shuliang Song, Yan Wang, Hongming Wang, Xiao Tian, Xiao Zhang, Qian Zhang, Qiang Wei, Kai Ji. Fucoidan-induced reduction of lipid accumulation in foam cells through overexpression of lysosome genes. International journal of biological macromolecules. 2024 Apr; 263(Pt 2):130451. doi: 10.1016/j.ijbiomac.2024.130451. [PMID: 38408582]
  • Robert W Suppa, Ryan J Andres, Jeffrey C Dunne, Ramsey F Arram, Thomas B Morgan, Hsuan Chen. Autotetraploid Induction of Three A-Genome Wild Peanut Species, Arachis cardenasii, A. correntina, and A. diogoi. Genes. 2024 Feb; 15(3):. doi: 10.3390/genes15030303. [PMID: 38540363]
  • Mohammed Bouhadi, Oussama Abchir, Imane Yamari, Amal El Hamsas El Youbi, Anas Azgaoui, Samir Chtita, Houda El Hajjouji, M'hammed El Kouali, Mohammed Talbi, Hassan Fougrach. Genotoxic effects and mitosis aberrations of chromium (VI) on root cells of Vicia faba and its molecular docking analysis. Plant physiology and biochemistry : PPB. 2024 Feb; 207(?):108361. doi: 10.1016/j.plaphy.2024.108361. [PMID: 38237423]
  • Yue Gao, Fei Li, Zhengshan Luo, Zhiwei Deng, Yan Zhang, Zhenbo Yuan, Changmei Liu, Yijian Rao. Modular assembly of an artificially concise biocatalytic cascade for the manufacture of phenethylisoquinoline alkaloids. Nature communications. 2024 Jan; 15(1):30. doi: 10.1038/s41467-023-44420-7. [PMID: 38167860]
  • Jiali Liu, Yan Wu, Yuanying Zhu, Cuicui Yu, Ying Zhang, Ting Luo, Juanna Wei, Hongjie Mu, Hui Xu. A new insight into mechanism of colchicine poisoning based on untargeted metabolomics. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155122. doi: 10.1016/j.phymed.2023.155122. [PMID: 37863002]
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